OBO-Edit 2.2
bcteo
1.1
definition
database_cross_reference
has_obo_format_version
has_obo_namespace
has_related_synonym
bcteo
part_of
part_of
Phase in which cells are loaded onto a carrier, substrate or threedimensional material.
bcteo
ID:0000000
Cell seeding
ID:0000000
Experimental phase aimed to amplify the number of cell in culture, through their doubling.
bcteo
ID:0000001
Cell expansion
ID:0000001
Property that is typical of a specific scaffold, depending not only on the material but even on the shape, the size, the structure etc.
bcteo
ID:0000002
Scaffold property
ID:0000002
Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
caro
ID:0000003
Cell
ID:0000003
Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
CARO:0000013
Property that reveals the reaction, either elastic or plastic, of a metal to an applied stress. Tensile strength, yield strength, elongation, reduction of area, hardness, impact strength, and bend ability are examples of mechanical properties.
bcteo
ID:0000004
Mechanical property
ID:0000004
Experimental environment where cells are expanded. It describes all the biological parameters related to cell expansion.
bcteo
ID:0000005
Cell expansion environment
ID:0000005
Property of materials, biological tissues or other objects, and their specific structural features. It can regard aspects of the outward appearance (shape, structure, pattern) as well as the form and structure of the internal parts.
bcteo
ID:0000006
Morphological property
ID:0000006
Tissue grown on substitute material.
bcteo
ID:0000007
Neoformed tissue
ID:0000007
Cell culture where the cells derive from a fresh tissue source.
obi
ID:0000008
Primary cell culture
ID:0000008
Cell culture where the cells derive from a fresh tissue source.
OBI:0100061
Mass per unit volume.
OPB:00546
bcteo
ID:0000009
Density
ID:0000009
Measure of the stiffness of an elastic material and is a quantity used to characterize materials. It is defined as the ratio of the stress along an axis over the strain along that axis in the range of stress in which Hooke's law holds.
bcteo
Elastic modulus
Tensile modulus
ID:0000010
Young's module
ID:0000010
The shape of the pores in the material.
bcteo
ID:0000011
Pore shape
ID:0000011
NCBITaxon:9940
ncbi_taxonomy
ID:0000012
Ovis aries
ID:0000012
Percentage of pore space.
bcteo
ID:0000013
Total porosity
ID:0000013
A round, flattened, platelike structure.
bcteo
ID:0000014
Disk
ID:0000014
Ability of a material to absorb energy when it is deformed elastically, and release that energy upon unloading.
bcteo
ID:0000015
Resilience
ID:0000015
A symmetrical three-dimensional shape, either solid or hollow, contained by six equal squares.
bcteo
ID:0000016
Cube
ID:0000016
Measure of the void (i.e., "empty") spaces in a material, and is a fraction of the volume of voids over the total volume, between 0 and 1, or as a percentage between 0 and 100%.
bcteo
ID:0000017
Porosity
ID:0000017
Liquid or gel designed to support the growth of microorganisms or cells. There are different types of media for growing different types of cells.
bcteo
ID:0000018
Culture medium
ID:0000018
Liquid or gel designed to expand cells. There are different types of media for culture different types of cells.
bcteo
ID:0000019
Expansion medium
ID:0000019
Population of cells cultured in vitro that are descended through one or more generations (and possible sub-cultures) from a single primary culture which was originally derived from part of an organism. The cells of such a population share common characteristics.
ero
ID:0000020
Cell line
ID:0000020
Population of cells cultured in vitro that are descended through one or more generations (and possible sub-cultures) from a single primary culture which was originally derived from part of an organism. The cells of such a population share common characteristics.
ERO:0000009
A methodical procedure carried out with the goal of verifying, falsifying, or establishing the validity of a hypothesis.
bcteo
ID:0000021
Experiment
ID:0000021
The magnitude of a quantity, such as length or mass, relative to a unit of measurement.
bcteo
ID:0000022
Size
ID:0000022
A study design that is done in a test environment, such as a culture dish, using an established cell culture procedure.
bcteo
In vitro study
ID:0000023
In vitro study
ID:0000023
In vitro study
OBI:0001285
A physical quality inhering in a bearer that has mass near a gravitational body.
pato
ID:0000024
Weight
ID:0000024
A physical quality inhering in a bearer that has mass near a gravitational body.
PATO:0000128
The pores in the material considered collectively.
bcteo
ID:0000025
Pore volume
ID:0000025
Geometrical description of the part of that space occupied by the object, as determined by its external boundary, abstracting from location and orientation in space, size, and other properties such as colour, content, and material composition.
bcteo
ID:0000026
Shape
ID:0000026
A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model.
obi
ID:0000027
In vivo study
ID:0000027
A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model.
OBI:0001199
A medical device manufactured to replace a missing biological structure, support a damaged biological structure, or enhance an existing biological structure.
bcteo
ID:0000028
Implant
ID:0000028
An substitute material implant out of the original place.
bcteo
ID:0000029
Ectopic implant
ID:0000029
A substitute material implant in the original place.
bcteo
ID:0000030
Orthotopic implant
ID:0000030
The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former.
bto
ID:0000031
Connective tissue
ID:0000031
The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former.
BTO:0000421
Ceramic materials not included in the ceramic list.
bcteo
ID:0000032
Other ceramic material
ID:0000032
Eveluation of the biochemical, molecular, mechanical events activated within the cell when cultured on a material. The nature of these intracellular events differs according to the type of cell and the considered material.
bcteo
ID:0000033
Cellular response evaluation
ID:0000033
Range of physical, mental, and behavioral characteristics distinguishing between masculinity and femininity.
snomedct
ID:0000034
Gender
ID:0000034
Range of physical, mental, and behavioral characteristics distinguishing between masculinity and femininity.
SNOMEDCT:263495000
A non-drug substance suitable for inclusion in systems which augment or replace the function of bodily tissues or organs.
bcteo
ID:0000035
Biomaterial
ID:0000035
an essential or inherent property of a system or of a material itself or within. It is independent of how much of the material is present and is independent of the form of the material. Intrinsic properties are dependent mainly on the chemical composition or structure of the material.
bcteo
ID:0000036
Intrinsic property
ID:0000036
Material's property that can be discerned without changing the chemical identity of the sample and that can be used to characterize matter and energy and their interactions.
bcteo
ID:0000037
Physical property
ID:0000037
Material's property that becomes evident during a chemical reaction.
bcteo
ID:0000038
Chemical property
ID:0000038
Property of a molecular entity to be attracted to, and tends to be dissolved by, water.
bcteo
ID:0000039
Hydrophilicity
ID:0000039
Ability of a material to perform with an appropriate host response in a specific situation.
bcteo
ID:0000040
Biocompatibility
ID:0000040
Property of a molecular entity that is repelled from a mass of water.
bcteo
ID:0000041
Hydrophobicity
ID:0000041
Property of a material that, upon placement within the organism, starts to dissolve (resorbed) and, in some cases, is slowly replaced by advancing tissue (such as bone).
bcteo
ID:0000042
Resorbability
ID:0000042
Stability of a molecule at high temperatures.
bcteo
ID:0000043
Thermal stability
ID:0000043
It measures a material's ability to conduct an electric current.
bcteo
ID:0000044
Electrical conductivity
ID:0000044
Property of a material to conduct heat.
bcteo
ID:0000045
Thermal conductivity
ID:0000045
A temporal measurement of the time period elapsed since an identifiable point in the life cycle of an organism. If a developmental stage is specified, the identifiable point would be the beginning of that stage. Otherwise the identifiable point must be specified such as planting (e.g. 3 days post planting).
mo
ID:0000046
Age
ID:0000046
A temporal measurement of the time period elapsed since an identifiable point in the life cycle of an organism. If a developmental stage is specified, the identifiable point would be the beginning of that stage. Otherwise the identifiable point must be specified such as planting (e.g. 3 days post planting).
MO:467
bcteo
ID:0000047
Cell seeding time
ID:0000047
Duration of the cellular expansion phase.
bcteo
ID:0000048
Cell expansion time
ID:0000048
Amount of used cells.
bcteo
ID:0000049
Cell quantity
ID:0000049
A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.
pato
ID:0000050
Diameter
ID:0000050
A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.
PATO:0001334
It gives an indication of the median or mean size of the pores on a membrane surface.
bcteo
ID:0000051
Pore size
ID:0000051
Studies about the mechanical behavior of materials, especially their motion and deformation under the action of forces, temperature changes, phase changes, and other external or internal agents.
bcteo
ID:0000052
Mechanics analysis
ID:0000052
It is the relative abundance of each pore size in a representative volume.
bcteo
ID:0000053
Pore size distribution
ID:0000053
Investigation of biomolecules, which are molecules that are involved in the maintenance and metabolic processes of all living organisms.
bcteo
ID:0000054
Biomolecular analysis
ID:0000054
The measurement of the extent of something along its greatest dimension.
bcteo
ID:0000055
Length
ID:0000055
The distance from the base of something to the top.
bcteo
ID:0000056
Height
ID:0000056
A piece of material measured along its smaller dimension or its crosswise grain.
bcteo
ID:0000057
Width
ID:0000057
A solid geometric figure with straight parallel sides and a circular or oval section.
bcteo
ID:0000058
Cylinder
ID:0000058
A three-dimensional surface, all points of which are equidistant from a fixed point.
bcteo
ID:0000059
Sphere
ID:0000059
Very high-resolution type of scanning probe microscopy, with demonstrated resolution on the order of fractions of a nanometer, more than 1000 times better than the optical diffraction limit. The information is gathered by "feeling" the surface with a mechanical probe. Piezoelectric elements that facilitate tiny but accurate and precise movements on (electronic) command enable the very precise scanning.
bcteo
AFM
ID:0000060
Atomic Force Microscopy
ID:0000060
Technique used to study and characterize materials. It is most useful for studying the viscoelastic behavior of polymers. A sinusoidal stress is applied and the strain in the material is measured, allowing one to determine the complex modulus. The temperature of the sample or the frequency of the stress are often varied, leading to variations in the complex modulus. Each test provides a stress-strain curve as output, which describes the relationship between the applied stress and the shown strain for a particular material.
bcteo
DMA
ID:0000061
Dynamic Mechanical Analysis
ID:0000061
Microtomography uses a similar technique as X-ray tomography systems used in medicine (CT Scans) but with much finer resolution. Multiple 2D X-ray images are stored while either the sample or the source / detector pair is rotated. Internal structures are reconstructed as a series of 2D cross sections (up to 2600 in a single scan) which are then used to analyze the two and three dimensional morphological parameters of the object. The process is non destructive and requires no special preparation of the specimen.
bcteo
Micro-CT
ID:0000062
X-ray microtomography
ID:0000062
A laboratory technique based on the PCR, which is used to amplify and simultaneously quantify a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample.
obi
Kinetic polymerase chain reaction
Quantitative real time polymerase chain reaction
Real Time PCR
qPCR
ID:0000063
Real-time polymerase chain reaction
ID:0000063
A laboratory technique based on the PCR, which is used to amplify and simultaneously quantify a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample.
OBI:0000893
Microscopy technique whereby a beam of electrons is transmitted through an ultra thin specimen, interacting with the specimen as it passes through. TEMs are capable of imaging at a significantly higher resolution than light microscopes: this enables to examine fine detail. An image is formed from the interaction of the electrons transmitted through the specimen; the image is magnified and focused onto an imaging device, such as a fluorescent screen, on a layer of photographic film, or to be detected by a sensor such as a CCD camera.
bcteo
TEM
ID:0000064
Transmission electron microscopy
ID:0000064
Gene expression microarray technology measures the relative activity of previously identified target genes and provide the gene expression profiling, which is the measurement, at once, of the activation of thousands of genes, to create a global picture of cellular function.
bcteo
DNA microarray
ID:0000065
Gene expression microarray
ID:0000065
DNA microarray
OBI:0400148
Measuring method consisting of turning elements in a sample into ions, isolating them according to the ratio between the mass and charge numbers and detecting it electrically.
PRIDE:0000027
obi
ID:0000066
Mass Spectrometry
ID:0000066
Measuring method consisting of turning elements in a sample into ions, isolating them according to the ratio between the mass and charge numbers and detecting it electrically.
OBI:0000470
Histofluorescence (fluorescence of the tissues under exposure to ultraviolet rays following the injection of a fluorescent substance or as a result of a natural fluorescing substance) accomplished by injection of antibody labeled with fluorochrome.
bcteo
IHF
ID:0000067
Immunohistofluorescence
ID:0000067
study of the microscopic anatomy of cells and tissues of plants and animals. It is commonly performed by examining cells and tissues by sectioning and staining, followed by examination under a light microscope or electron microscope. Histological studies may be conducted via tissue culture, where live cells can be isolated and maintained in a proper environment outside the body for various research projects. The ability to visualize or differentially identify microscopic structures is frequently enhanced through the use of histological stains.
OBI:0600020
bcteo
ID:0000068
Histochemical staining
ID:0000068
OBI:0600020
the visual examination of cells or tissue (or images of them) with an assessment regarding a quality of the cells or tissue. Parts are: staining, imaging, judgement
Method using an antibody coupled with some colouring agent to detect a specific protein within a tissue sample. In some cases the primary antibody is directly linked to a colouring agent, more often the primary antibody is targeted by a secondary antibody, targeting the primary antibody.
mi
IHC
ID:0000069
Immunohistochemistry
ID:0000069
Method using an antibody coupled with some colouring agent to detect a specific protein within a tissue sample. In some cases the primary antibody is directly linked to a colouring agent, more often the primary antibody is targeted by a secondary antibody, targeting the primary antibody.
MI:1198
Electron microscope that produces images of a sample by scanning it with a focused beam of electrons. The electrons interact with electrons in the sample, producing various signals that can be detected and that contain information about the sample's surface topography and composition. The electron beam is generally scanned in a raster scan pattern, and the beam's position is combined with the detected signal to produce an image. SEM can achieve resolution better than 1 nanometer.
bcteo
SEM
ID:0000070
Scanning electron microscopy
ID:0000070
Investigations about the form and structure of organisms and their specific features.
bcteo
ID:0000071
Morphology analysis
ID:0000071
Cartilage cells. They make the structural components of cartilage.
bto
ID:0000072
Chondrocyte
ID:0000072
Cartilage cells. They make the structural components of cartilage.
BTO:0000249
Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.
cl
ID:0000073
Osteoblast
ID:0000073
Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.
CL:0000062
A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues.
bto
MSC
ID:0000074
Mesenchymal stem cell
ID:0000074
A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues.
BTO:0003298
A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
obi
ID:0000075
Organism
ID:0000075
A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
OBI:0100026
Amount of cells per volume of medium used.
bcteo
ID:0000076
Cell concentration
ID:0000076
Affymetrix is a US company that manufactures DNA microarrays.
bcteo
ID:0000077
Affymetrix technology
ID:0000077
Time when the substitue material is within the host.
bcteo
ID:0000078
Implant time
ID:0000078
A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body.
bto
ID:0000079
Cartilage
ID:0000079
A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body.
BTO:0000206
The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.
BTO:0000141
bto
ID:0000080
Bone marrow
ID:0000080
The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.
BTO:0000141
Connective tissue in which fat is stored and which has the cells distended by droplets of fat.
BTO:0001487
bto
ID:0000081
Adipose tissue
ID:0000081
Connective tissue in which fat is stored and which has the cells distended by droplets of fat.
BTO:0001487
A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro.
obi
ID:0000082
Donor
ID:0000082
A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro.
OBI:1110087
Organism for the implant.
bcteo
ID:0000083
Host
ID:0000083
Solid, jelly-like material that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state. By weight, gels are mostly liquid, yet they behave like solids due to a three-dimensional cross-linked network within the liquid. It is the crosslinking within the fluid that give a gel its structure (hardness) and contribute to the adhesive stick.
bcteo
ID:0000084
Gel
ID:0000084
Metal materials not included in the previous list.
bcteo
ID:0000085
Other metal material
ID:0000085
Steel alloy with a minimum of 10.5%[1] to 11% chromium content by mass. It does not readily corrode, rust or stain with water as ordinary steel does, but despite the name it is not fully stain-proof, most notably under low oxygen, high salinity, or poor circulation environments.
bcteo
Inox
Inox steel
ID:0000086
Stainless steel
ID:0000086
Other polymeric materials not included in the previous list.
bcteo
ID:0000087
Other polymeric materials
ID:0000087
Hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
nci_thesaurus
LC/MS
ID:0000088
Liquid Chromatography-Mass Spectrometry
ID:0000088
Hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
Thesaurus:Liquid_Chromatography_Mass_Spectrometry
Chemical element with symbol Ti and atomic number 22. It has a low density and is a strong, lustrous, corrosion-resistant (including sea water, aqua regia and chlorine) transition metal with a silver color.
bcteo
ID:0000089
Titanium
ID:0000089
Chemical compound of aluminium and oxygen with the chemical formula Al2O3.
bcteo
Aloxide
Aluminium oxide
ID:0000090
Alumina
ID:0000090
Non-metallic structural material that combines hardness, reduced fragility, and chemical inertness with high chemical stability in aggressive environments throughout a wide temperature range.
bcteo
ID:0000091
Partially stabilised zirconia
ID:0000091
Subset of the thermoplastic polyethylene, characterized by extremely long chains, with a molecular weight usually between 2 and 6 million. The longer chain serves to transfer load more effectively to the polymer backbone by strengthening intermolecular interactions.
bcteo
HMPE
HPPE
High-modulus polyethylene
High-performance polyethylene
UHMW
UHMWPE
ID:0000092
Ultra high molecular weight polyethylene
ID:0000092
Gel material not listed among the gels.
bcteo
ID:0000093
Other gel
ID:0000093
Polycrystalline material produced through controlled crystallization of base glass.
bcteo
ID:0000094
Glass ceramic
ID:0000094
Family of bioactive glasses, composed of SiO2, Na2O, CaO and P2O5 in specific proportions.
bcteo
ID:0000095
Bioglass
ID:0000095
Calcium salt of phosphoric acid with the chemical formula Ca3(PO4)2.
bcteo
BPL
Bone phosphate of lime
Tribasic calcium phosphate
ID:0000096
Tricalcium phosphate
ID:0000096
Athermoplastic aliphatic polyester derived from renewable resources.
bcteo
PLA
Polylactide
ID:0000097
Polylactic acid
ID:0000097
Chemical compound with the formula CaO.
bcteo
Burnt lime
Quicklime
ID:0000098
Calcium oxide
ID:0000098
Chemical compound with the formula CaCO3.
bcteo
ID:0000099
Calcium carbonate
ID:0000099
Very soft sulfate mineral composed of calcium sulfate dihydrate, with the chemical formula CaSO4·2H2O.
bcteo
ID:0000100
Gypsum
ID:0000100
The collection of material entities and their qualities that are located near a live organism, tissue or cell and can influence its growth.
obi
ID:0000101
Growth environment
ID:0000101
The collection of material entities and their qualities that are located near a live organism, tissue or cell and can influence its growth.
OBI:0000997
Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships.
caro
ID:0000102
Tissue
ID:0000102
Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships.
CARO:0000043
Natural tissue located within the organism in the natural site.
bcteo
ID:0000103
Natural tissue
ID:0000103
Tissue that has been extracted from the organism.
bcteo
ID:0000104
Isolated tissue
ID:0000104
The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone.
bto
ID:0000105
Bone
ID:0000105
The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone.
BTO:0000140
NCBITaxon:9606
ncbi_taxonomy
ID:0000106
Homo sapiens
ID:0000106
NCBITaxon:10090
ncbi_taxonomy
ID:0000107
Mus musculus
ID:0000107
NCBITaxon:10116
ncbi_taxonomy
ID:0000108
Rattus norvegicus
ID:0000108
NCBITaxon:9986
ncbi_taxonomy
ID:0000109
Oryctolagus cuniculus
ID:0000109
NCBITaxon:9913
ncbi_taxonomy
ID:0000110
Bos taurus
ID:0000110
NCBITaxon:9925
ncbi_taxonomy
ID:0000111
Capra aegagrus hircus
ID:0000111
A physical quality inhering in a bearer that has mass near a gravitational body.
pato
ID:0000112
Weight
ID:0000112
A physical quality inhering in a bearer that has mass near a gravitational body.
PATO:0000128
Group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of vertebrates. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content.
bcteo
ID:0000113
Collagen
ID:0000113
An aminoglycan consisting of beta-(1->4)-linked D-glucosamine residues.
chebi
ID:0000114
Chitosan
ID:0000114
An aminoglycan consisting of beta-(1->4)-linked D-glucosamine residues.
CHEBI:16261
Inorganic, nonmetallic solid prepared by the action of heat and subsequent cooling.
bcteo
ID:0000115
Ceramic
ID:0000115
Name given to a family of minerals containing calcium ions (Ca2+) together with orthophosphates (PO43-)
bcteo
ID:0000116
Calcium-phosphate based ceramic
ID:0000116
Element, compound, or alloy that is a good conductor of both electricity and heat. Metals are usually shiny, malleable and ductile.
bcteo
ID:0000117
Metal
ID:0000117
A nucleic acid microarray assay that uses the GeneChip System as the platform for analyzing complex genetic information.
ero
ID:0000118
Affymetrix chip
ID:0000118
A nucleic acid microarray assay that uses the GeneChip System as the platform for analyzing complex genetic information.
ERO:0001265
A mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.
chebi
ID:0000119
Polymer
ID:0000119
A mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.
CHEBI:60027
The effect/reaction/interaction/response of a given agent, such as a biomaterial or drug, upon a living organism or on living tissue.
bcteo
ID:0000120
Bioactivity
ID:0000120
It refers to any material that once placed in the human body has minimal interaction with its surrounding tissue. Generally a fibrous capsule might form around bioinert implants hence its biofunctionality relies on tissue integration through the implant.
bcteo
ID:0000121
Bioinertness
ID:0000121
Maximum stress that a material can withstand while being stretched or pulled before failing or breaking.
bcteo
UTS
TS
Tensile strength
Ultimate strength
ID:0000122
Ultimate tensile strength
ID:0000122
It measures the substance's resistance to uniform compression. It is defined as the ratio of the infinitesimal pressure increase to the resulting relative decrease of the volume.
bcteo
ID:0000123
Bulk modulus
ID:0000123
The Affymetrix protocol first steps are RNA isolation and conversion to cDNA and cRNA. The RNA is then hybridized with the array probes (25-mer) and the unbound material washed away. Finally a signal amplifying reaction is performed, the microarray chip is ready to be scanned and the signal acquired.
bcteo
ID:0000124
Affymetrix protocol
ID:0000124
DAT files contain raw image data; CEL files contain information about the expression levels of the individual probes; CHP files contain information about probe sets; EXP files contain information about experimental conditions and protocols. The CEL file (the most important for analysis) contains information about where each probe is on the chip, an intensity value, standard deviation of the intensity, the number of pixels used to calculate the intensity value, a flag to indicate an outlier as calculated by the algorithm and a user defined flag indicating the feature should be excluded from future analysis.
bcteo
ID:0000125
Affymetrix raw data file
ID:0000125
Illumina, Inc. is a US company that develops, manufactures and markets integrated systems for the analysis of genetic variation and biological function.
bcteo
ID:0000126
Illumina technology
ID:0000126
In Illumina's BeadArray Technology each bead is covered with hundreds of thousands of copies of a specific oligonucleotide that act as the capture sequences in one of Illumina's assays. Examples are MouseWG-6 v2.0 Expression BeadChip, HumanWG-6 Expression BeadChip.
bcteo
ID:0000127
Illumina chip
ID:0000127
Illumina BeadChip gene expression summary file contains the expression levels for each bead type on the arrays on the BeadChip.
bcteo
ID:0000128
Illumina raw data file
ID:0000128
Other gene expression microarray techniques not included in the previous list.
bcteo
ID:0000129
Other gene expression microarray technologies
ID:0000129
It stains nucleic acids blue and polysaccharides purple.
FBbi:00000049
bcteo
ID:0000130
Toluidine blue stain
ID:0000130
Family of polyvalent basic dyes used to stain acidic polysaccharides such as glycosaminoglycans in cartilages and other body structures, some types of mucopolysaccharides, sialylated glycocalyx of cells etc.
NDF-RT:N0000166971
bcteo
ID:0000131
Alcian blue stains
ID:0000131
Three-colour staining protocol able to distinguish cells from surrounding connective tissue. Most recipes produce red keratin and muscle fibers, blue or green collagen and bone, light red or pink cytoplasm, and dark brown to black cell nuclei.
bcteo
ID:0000132
Masson's trichrome stain
ID:0000132
Staining methods not listed before.
bcteo
ID:0000133
Other stain
ID:0000133
Static mode operation where the static tip deflection is used as a feedback signal. The force between the tip and the surface is kept constant during scanning by maintaining a constant deflection.
bcteo
ID:0000134
Contact mode technique
ID:0000134
The tip of the cantilever does not contact the sample surface. The van der Waals forces, which are strongest from 1 nm to 10 nm above the surface, or any other long range force which extends above the surface acts to decrease the resonance frequency of the cantilever. The absence of repulsive forces permits its use in the imaging of soft samples and does not require conducting samples.
bcteo
ID:0000135
Non-contact mode technique
ID:0000135
The cantilever is driven to oscillate up and down at near its resonance frequency by a small piezoelectric element mounted in the AFM tip holder similar to non-contact mode. However, the amplitude of this oscillation is greater than 10 nm, typically 100 to 200 nm. The interaction of forces acting on the cantilever when the tip comes close to the surface, Van der Waals forces, dipole-dipole interactions, electrostatic forces, etc. cause the amplitude of this oscillation to decrease as the tip gets closer to the sample.
bcteo
ID:0000136
Tapping mode technique
ID:0000136
Mechanical test where balanced inward ("pushing") forces are applied to different points of a material or structure. Applied forces have no net sum or torque directed. By inducing compression, mechanical properties such as compressive strength or modulus of elasticity, can be measured.
bcteo
ID:0000137
Compression test
ID:0000137
Materials science test in which a sample is subjected to a controlled tension until failure. Properties that are directly measured via a tensile test are ultimate tensile strength, maximum elongation and reduction in area. From these measurements the following properties can also be determined: Young's modulus, Poisson's ratio, yield strength, and strain-hardening characteristics
bcteo
ID:0000138
Tensile test
ID:0000138
Used to define a material's ability to resist deformation under load.
bcteo
ID:0000139
Fracture test
ID:0000139
Mechanical test where an applied torque generate a twisting of the material.
bcteo
ID:0000140
Torsion test
ID:0000140
Test not included in the previous list.
bcteo
ID:0000141
Other mechanical test
ID:0000141
The Illumina Gene Expression microarray system uses total RNA as starting material (minimum of 250ng of total RNA at a minimum concentration of 25ng/ul). RNA isolation, cDNA synthesis, and in vitro transcription amplification are followed by hybridization on 50-mer probe sequences (several hundred thou- sand copies of the probe across the bead surface).
bcteo
ID:0000142
Illumina protocol
ID:0000142
The direct method is a one-step staining method and involves a labeled antibody (e.g. FITC-conjugated antiserum) reacting directly with the antigen in tissue sections. While this technique utilizes only one antibody and therefore is simple and rapid, the sensitivity is lower due to little signal amplification, such as with indirect methods, and is less commonly used than indirect methods.
bcteo
ID:0000143
Direct detection method protocol
ID:0000143
The indirect method involves an unlabeled primary antibody (first layer) that binds to the target antigen in the tissue and a labeled secondary antibody (second layer) that reacts with the primary antibody. The secondary antibody must be raised against the IgG of the animal species in which the primary antibody has been raised. This method is more sensitive than direct detection strategies because of signal amplification due to the binding of several secondary antibodies to each primary antibody if the secondary antibody is conjugated to the fluorescent or enzyme reporter.
bcteo
ID:0000144
Indirect detection method protocol
ID:0000144
Tissue fixation in formalin (an aqueous solution containing formaldehyde) in order to prevent it from decaying or degeneration and to examine it clearly under a microscope for histological, pathological or cytological studies. The fixed tissue is then embedded in paraffin wax in order to solidify it and easily cut its fine sections.
bcteo
ID:0000145
Formalin fixed paraffin embedded (FFPE) protocol
ID:0000145
A histology technique that involves the staining of cells with a blue nuclear stain, hemalum followed by counterstaining with eosin, which stains eosinophilic structures in various shades of red, pink and orange.
ero
ID:0000146
Hematoxylin-eosin stain
ID:0000146
A histology technique that involves the staining of cells with a blue nuclear stain, hemalum followed by counterstaining with eosin, which stains eosinophilic structures in various shades of red, pink and orange.
ERO:0001605
An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
go
ID:0000147
Antibody
ID:0000147
An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
GO:0042571
Stained tissue are studied to define and examine: bulk tissues (for example muscle fibers or connective tissue), cell populations (i.e. different blood cells), or molecules within individual cells (for example DNA, proteins, lipids, carbohydrates).
bcteo
ID:0000148
Histochemistry stained tissue
ID:0000148
Biological staining is used to mark cells in flow cytometry, and to flag proteins or nucleic acids in tissues. Examples of proteins examined with this technique are BSP, Col I, Col II.
bcteo
ID:0000149
Immunohistochemistry stained tissue
ID:0000149
Naturally occurring mineral form of calcium apatite with the formula Ca5(PO4)3(OH). Up to 50% of bone by weight is a modified form of hydroxyapatite (known as bone mineral).
bcteo
HA
Hydroxylapatite
Synthetic hydroxyapatite
ID:0000150
Hydroxyapatite
ID:0000150
Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times.
nci_thesaurus
MS/MS
ID:0000151
Tandem Mass Spectrometry
ID:0000151
Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times.
Thesaurus:Tandem_Mass_Spectrometry
MS/MS output file containing mass spectra, which show peaks due to the masses of the various ions produced by the fragmentation process. Spectra are converted into peptide sequence tags, used to identify a peptide in a protein database.
bcteo
ID:0000152
Mass spectra file
ID:0000152
The protocol depends on the ion source different requirements for volume, concentration, and composition of the analyte solution. Furthermore, in protein mass spectrometry usually the protein of interest is cleaved into peptides before analysis, either by in-gel digestion or by proteolysis in solution.
bcteo
ID:0000153
Mass spectrometry sample preparation protocol
ID:0000153
Materials made from two or more constituent materials with significantly different physical or chemical properties, that when combined, produce a material with characteristics different from the individual components. The individual components remain separate and distinct within the finished structure.
bcteo
ID:0000154
Composite
ID:0000154
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
cl
ID:0000155
Fibroblast
ID:0000155
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
CL:0000057
Nucleic acid reagent that is a short strand of nucleic acid that serves as a starting point for DNA or RNA synthesis.
ero
ID:0000156
Primer
ID:0000156
Nucleic acid reagent that is a short strand of nucleic acid that serves as a starting point for DNA or RNA synthesis.
ERO:0000631
Quantification can be relative or absolute. Relative quantification is based on internal reference genes to determine fold-differences in expression of the target gene. Absolute quantification gives the exact number of target DNA molecules by comparison with DNA standards. Examples of genes examined with this technique are COL1A1, COL2A1.
bcteo
ID:0000157
Quantification file
ID:0000157
Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA.
nci_thesaurus
ID:0000158
DNA-polymerase
ID:0000158
Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA.
Thesaurus:DNA_Polymerase
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
msh
ID:0000159
Immunoblotting
ID:0000159
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
MSH:D015151
A gel matrix through which molecules are separated, usually by size or charge, under the influence of an electrical field.
nci_thesaurus
ID:0000160
Electrophoresis gel
ID:0000160
A gel matrix through which molecules are separated, usually by size or charge, under the influence of an electrical field.
Thesaurus:Electrophoresis_Gel
Procedure to identify and quantify proteins. A mixture of protein is first submitted to an electrophoresis in denaturing condition and then electro-transferred from the gel to a membrane. The membrane is then incubated with a primary antibody specific for a given protein or a specific residue modification in the sample under analysis. A secondary antibody, radiolabelled or fused to fluorophore or to a chromogenic enzyme, targets the first antibody and allows the visualisation of the protein band on the membrane.
mi
ID:0000161
Western blot
ID:0000161
Procedure to identify and quantify proteins. A mixture of protein is first submitted to an electrophoresis in denaturing condition and then electro-transferred from the gel to a membrane. The membrane is then incubated with a primary antibody specific for a given protein or a specific residue modification in the sample under analysis. A secondary antibody, radiolabelled or fused to fluorophore or to a chromogenic enzyme, targets the first antibody and allows the visualisation of the protein band on the membrane.
MI:0113
A multistep process in which a mixture of RNA is separated by gel electrophoresis, that is, separation of ionic solutes based on differences in rate of migration in an applied electric field using a semisolid colloid such as agarose or acrylamide as the support medium, followed by transfer to a membrane such as nitrocellulose or nylon and detection of specific RNAs by hybridization of a tagged or labelled polynucleotide, usually a single DNA fragment with a specific, known sequence.
mmo
ID:0000162
Northern blot
ID:0000162
A multistep process in which a mixture of RNA is separated by gel electrophoresis, that is, separation of ionic solutes based on differences in rate of migration in an applied electric field using a semisolid colloid such as agarose or acrylamide as the support medium, followed by transfer to a membrane such as nitrocellulose or nylon and detection of specific RNAs by hybridization of a tagged or labelled polynucleotide, usually a single DNA fragment with a specific, known sequence.
MMO:0000339
A standard procedure to identify DNA fragments containing specific gene sequences. In this procedure i) a genome is fragmented using a restriction enzyme ii) the generated fragments are separated by electrophoresis iii) the fragments are transferred to a membrane iv)the membrane is incubated with a radio labelled probe that hybridises any complementary subsequence.
mi
ID:0000163
Southern blot
ID:0000163
A standard procedure to identify DNA fragments containing specific gene sequences. In this procedure i) a genome is fragmented using a restriction enzyme ii) the generated fragments are separated by electrophoresis iii) the fragments are transferred to a membrane iv)the membrane is incubated with a radio labelled probe that hybridises any complementary subsequence.
MI:0103
Image of the matrix gel containing the separated target molecules (proteins or nucleic acids).
bcteo
ID:0000164
Agarose gel image
ID:0000164
Any of the various methods that use a dye, reagent, or other material for producing coloration in tissues or microorganisms for microscopic examination.
pdq
ID:0000165
Staining protocol
ID:0000165
Any of the various methods that use a dye, reagent, or other material for producing coloration in tissues or microorganisms for microscopic examination.
PDQ:CDR0000575401
Tissues that, under exposure to ultraviolet rays, produce fluorescence. Examples of proteins examined with this technique are BSP, Col I, Col II.
bcteo
ID:0000166
Immunohistofluorescence stained tissue
ID:0000166
Biodegradable polyester prepared by ring opening polymerization of caprolactone using a catalyst such as stannous octoate.
bcteo
PCL
ID:0000167
Polycaprolactone
ID:0000167
High-resolution image acquired from AFM technology. It shows a combination of surface (topological information about the roughness and the features of the surface is derived) and mechanical information, by means of the cantilever which measures the elasticity of the tested sample.
bcteo
ID:0000168
AFM image
ID:0000168
The stress applied to fracture a specimen.
bcteo
Breaking strength
Fracture strength
ID:0000170
Fracture maximum load
ID:0000170
The strain applied to fracture a specimen.
bcteo
ID:0000171
Fracture maximum strain
ID:0000171
Measure of the amount of torque that a radial shaft can sustain during its rotation in a mechanical system.
bcteo
Torsional stiffness
ID:0000172
Torsion modulus
ID:0000172
Maximum stress that a material can withstand while being stretched or pulled before failing or breaking.
bcteo
Tensile strength
Ultimate strength
Ultimate tensile strength
ID:0000173
Maximum load
ID:0000173
Maximum strain that a material can withstand while being stretched or pulled before failing or breaking.
bcteo
ID:0000174
Maximum strain
ID:0000174
bcteo
ID:0000175
Other biomaterials
ID:0000175
Polyether compound whose structure is H-(O-CH2-CH2)n-OH.
bcteo
PEG
ID:0000176
Polyethylene glycol
ID:0000176
Anionic polysaccharide distributed widely in the cell walls of brown algae, where through binding with water it forms a viscous gum. Characterized by biocompatibility and simple gelation with divalent cations such as Ca2+.
bcteo
ID:0000177
Alginate
ID:0000177
Gel obtained from chitosan, a linear polysaccharide composed of randomly distributed beta-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit), made by treating shrimp and other crustacean shells with the alkali sodium hydroxide.
bcteo
ID:0000178
Chitosan gel
ID:0000178
Translucent, colorless, brittle (when dry), flavorless solid substance, derived from collagen obtained from various animal by-products.
bcteo
ID:0000179
Gelatin
ID:0000179
Gel based on dextran, a complex, branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 3 to 2000 kilodaltons).
bcteo
ID:0000180
Dextran gel
ID:0000180
Gel deriving from polyethylene glycol, produced by the interaction of ethylene oxide with water.
bcteo
ID:0000181
Polyethylene glycol gel
ID:0000181
Material whose components are chitosan and alginate.
bcteo
ID:0000182
Chitosan-alginate composite
ID:0000182
Material whose components are collagen and hydroxyapatite.
bcteo
ID:0000183
Collagen-hydroxyapatite composite
ID:0000183
Material whose components are hydroxyapatite and polycaprolactone.
bcteo
PCL-HA
ID:0000184
Polycaprolactone-hydroxyapatite composite
ID:0000184
Material whose components are chitosan and collagen.
bcteo
ID:0000185
Collagen-chitosan composite
ID:0000185
Material whose components are collagen and polycaprolactone.
bcteo
ID:0000186
Polycaprolactone-collagen composite
ID:0000186
Composite material not listed among the composite materials.
bcteo
ID:0000187
Other composite
ID:0000187
Polymer prepared starting from glycolic acid by means of polycondensation or ring-opening polymerization.
bcteo
PGA
Polyglycolide
ID:0000188
Polyglycolic acid
ID:0000188
Polymer for tissue engineering applications composed by polylysine, used to confer endothelial cell attachment properties to the poloxamine-based polymer, and acrylate, which makes it photo-cross-linkable.
bcteo
PPA
ID:0000189
Poloxamine-polylysine acrylate
ID:0000189
Copolymer synthesized by means of random ring-opening co-polymerization of two different monomers, the cyclic dimers (1,4-dioxane-2,5-diones) of glycolic acid and lactic acid.
bcteo
PLGA
ID:0000190
Polylactic-co-glycolic acid
ID:0000190
Dataset of physical parameters about mechanical tests performed, such as the applied intensity and velocity of strain.
bcteo
ID:0000191
Mechanical parameter of load
ID:0000191
High-resolution image acquired from SEM technique. Morphological information about sample surface and three-dimensional structure is derived.
bcteo
ID:0000192
SEM image
ID:0000192
High-resolution image of TEM acquisition. The image is formed from the interaction of the electrons transmitted through the specimen; it enables to examine fine details, even as small as a single column of atoms.
bcteo
ID:0000193
TEM image
ID:0000193
High-resolution 2D image from X-ray technology. Since X-rays interact with matter, it's possible to highlight specific physical entities (i.e. tissues, organs), having different X-ray adsorption properties, due to their chemico-physical nature.
bcteo
ID:0000194
X ray image
ID:0000194
Wavelength of the radiation (usually coming from a laser line) used to stimulate fluorescence in the measured object. The stimulated dye will emit radiation with a particular Emission Wavelength.
bcteo
ID:0000195
Excitation wavelength
ID:0000195
Material property consisting in becoming soft when heated and hard when cooled.
bcteo
ID:0000196
Thermoplasticity
ID:0000196
Mechanical parameter for brittle material, defined as a material's ability to resist deformation under load.
bcteo
Bend strength
Fracture strength
Modulus of rupture
ID:0000197
Flexural strength
ID:0000197
It first aims at fixing samples, then at dehydrating them, through a ethanols scale, and finally at coating samples with gold/palladium alloy.
bcteo
ID:0000198
SEM protocol
ID:0000198
It aims at fixing samples, dehydrating and including them into resin (infiltration and embedding).
bcteo
ID:0000199
TEM protocol
ID:0000199
Form of polylactide, having lactic acid a chiral nature, and it is the product resulting from polymerization of L,L-lactide.
bcteo
L-lactide
PLLA
ID:0000200
Poly-L-lactide
ID:0000200
It is a PCR real time preceded by a reverse transcription step (reverse transcription step = an RNA strand is reverse transcribed into its DNA complement using the enzyme reverse transcriptase)
obi
qRT-PCR
ID:0000201
Real-time reverse-transcription polymerase chain reaction
ID:0000201
It is a PCR real time preceded by a reverse transcription step (reverse transcription step = an RNA strand is reverse transcribed into its DNA complement using the enzyme reverse transcriptase)
OBI:0000911
Network of fibers that hold cells together. It is found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. It is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
nci_thesaurus
ID:0000202
Extracellular matrix
ID:0000202
Network of fibers that hold cells together. It is found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. It is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
NCIThesaurus:C13232
Extracellular signaling molecule involved in control of target cell proliferation, cell survival, and cell differentiation.
nci_thesaurus
ID:0000203
Growth factor
ID:0000203
Extracellular signaling molecule involved in control of target cell proliferation, cell survival, and cell differentiation.
NCIThesaurus:C20424
Measurable characteristic related to the concentration of growth factors.
bcteo
ID:0000204
Growth factor concentration
ID:0000204
It defines the organism species the growth factor comes from.
bcteo
ID:0000205
Growth factor species
ID:0000205
It defines the specific isoform of the growth factor.
bcteo
ID:0000206
Growth factor isoform
ID:0000206
NCBITaxon:9825
ncbi_taxonomy
ID:0000207
Sus scrofa domesticus
ID:0000207
Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell.
bto
ADSC
ID:0000208
Adipose-derived stem cell
ID:0000208
Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell.
BTO:0005198
Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent.
nci_thesaurus
ESC
ID:0000209
Embryonic stem cell
ID:0000209
Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent.
NCIThesaurus:C12935
Material whose components are silicon, tricalcium phosphate and hydroxyapatite.
bcteo
ID:0000210
Silicon-substituted tricalcium phosphate and hydroxyapatite
ID:0000210
A continuous protein fiber consisting primarily of fibroids. It is synthesized by a variety of insects and arachnids.
msh
ID:0000211
Silk
ID:0000211
A continuous protein fiber consisting primarily of fibroids. It is synthesized by a variety of insects and arachnids.
MeSH:D047011
A titanium molecular entity that has formula O2Ti.
chebi
ID:0000212
Titanium dioxide
ID:0000212
A titanium molecular entity that has formula O2Ti.
CHEBI:32234
Material whose components are polycaprolactone, collagen and hydroxyapatite.
bcteo
ID:0000213
Polycaprolactone-hydroxyapatite-collagen
ID:0000213
Material whose components are polycaprolactone and tricalcium phosphate.
bcteo
ID:0000214
Polycaprolactone-tricalcium phosphate
ID:0000214
Functionalized material. A blend of corn starch with polycaprolactone used to produce three-dimensional fibre meshes scaffolds, coupled with a calcium silicate solution for the in situ functionalization with Si-OH groups.
bcteo
ID:0000215
From: Rodrigues AI et al. Bioactive starch-based scaffolds and human adipose stem cells are a good combination for bone tissue engineering. Acta Biomater. 2012, 8(10):3765-76.
SPCL-Si
ID:0000215
Material whose components are collagen and polylactic-co-glycolic acid.
bcteo
ID:0000216
Collagen-polylactic-co-glycolic acid
ID:0000216
Material whose components are polycaprolactone and polylactic-co-glycolic acid.
bcteo
ID:0000217
Polycaprolactone-polylactic-co-glycolic acid
ID:0000217
Ceramic material where Ca, Sr, Zn and Si ions have been incorporated.
bcteo
Sr-HT-gahnite
ID:0000218
From: Roohani-Esfahani SI et al. Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomater. 2013, 9(6):7014-24.
Strontium-hardystonite-gahnite
ID:0000218
Baghdadite scaffolds were coated in polycaprolactone and nanoparticles of bio-glass. The PCL coating increased the scaffolds toughness while nBG enhanced bioactivity.
bcteo
ID:0000219
Baghdadite-polycaprolactone-glass nanoparticle
ID:0000219
Fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features.
bcteo
ID:0000220
From: Jonsson D et al. The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodontal Res. 2011, 46(2):153-7.
Periodontal ligament cell
ID:0000220
Functionalization is employed for surface modification of industrial materials in order to achieve desired surface properties. It consists in modifying the surface of a material by bringing physical, chemical or biological characteristics different from the ones originally found on the surface of a material. The modification can be done by different methods with a view to altering a wide range of characteristics of the surface, such as: roughness, hydrophilicity, surface charge, surface energy, biocompatibility and reactivity. Coating of materials is a type of functionalization.
bcteo
ID:0000221
Functionalization
ID:0000221
Material whose components are bioglass, collagen and phosphatidylserine.
bcteo
ID:0000222
Bioglass-collagen-phosphatidylserine
ID:0000222
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as elastomers, as coatings, as fibers and as foams.
msh
ID:0000223
Polyurethane
ID:0000223
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as elastomers, as coatings, as fibers and as foams.
MeSH:D011140
Material whose components are collagen and glycosaminoglycan
msh
Collagen-GAG
ID:0000224
Collagen-glycosaminoglycan
ID:0000224
Material whose components are collagen and glycosaminoglycan
MeSH:C058506
Material whose components are calcium-phosphate based ceramic and chitosan.
bcteo
ID:0000225
Calcium-phosphate based ceramic-chitosan
ID:0000225
Cell derived from bone.
bcteo
BDC
ID:0000226
Bone-derived cell
ID:0000226
Multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells.
pdq
UCMSC
umbilical cord blood-derived mesenchymal stem cells
ID:0000227
Umbilical cord mesenchymal stem cell
ID:0000227
Multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells.
PDQ:CDR0000633689
Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen.
bto
ID:0000228
MC3T3-E1 cell line
ID:0000228
Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen.
BTO:0001957
Level of connection between pores. It improves mass transport throughout the material.
bcteo
Interpore connectivity
ID:0000229
Pore interconnection
ID:0000229
Addition of functional groups/peptides/proteins/molecules/growth factors onto the surface of a material by chemical synthesis methods. Chemical functionalization is one of the main methods to obtain the desired physical and chemical properties of materials, such as hydrophilicity or bioactivation.
bcteo
ID:0000230
Chemical functionalization
ID:0000230
Alteration of the the surface topography of a material, producing microscale and nanoscale features in a well-controlled manner with nanocoating, film deposition, or in situ surface modifications at nanoscale level, with the aim to improve the material performances.
bcteo
ID:0000231
Physical functionalization
ID:0000231
The procedure used to obtain something from a mixture or compound by chemical or physical or mechanical means.
efo
ID:0000232
Extraction protocol
ID:0000232
The procedure used to obtain something from a mixture or compound by chemical or physical or mechanical means.
EFO:0000490
The condition of an organism in all aspects (e.g., functional or metabolic efficiency).
exo
ID:0000233
Health status
ID:0000233
The condition of an organism in all aspects (e.g., functional or metabolic efficiency).
ExO:0000038
The percentage of cells plated (seeded, inoculated) which attach to the surface of the culture vessel within a specified period of time. The conditions under which such a determination is made should always be stated.
bcteo
Attachment efficiency
ID:0000234
From: Worthington Tissue Dissociation Guide, http://www.worthington-biochem.com/tissuedissociation/glossary.html#attachment
Seeding efficiency
ID:0000234
It determines whether a product or compound will have any toxic effect due to leachables on living cells. Generally used as a screening tool for raw materials or component products before they are put into the design of a medical device.
bcteo
ID:0000235
Cytotoxicity text
ID:0000235
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
msh
FACS
Fluorescence-Activated Cell Sorting
ID:0000236
Flow Cytometry
ID:0000236
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
MeSH:D005434
bcteo
ID:0000237
NIH/3T3 cell line
ID:0000237
Cell derived from trabecular (or cancellous, or spongy) bone.
bcteo
ID:0000238
Trabecular bone cell
ID:0000238
Cell derived from cortical bone.
bcteo
ID:0000239
Cortical bone cell
ID:0000239
Primary human marrow stromal cells (MSCs) cultured from adult bone marrow (BM) mononuclear cells (MNCs).
BTO:0004122
bcteo
BMSC
ID:0000240
Bone marrow stromal cell
ID:0000240
Multipotent stem cells obtained from dental pulp.
bcteo
DPSC
ID:0000241
Dental pulp stem cell
ID:0000241
They are known to be able to transform into liver, nerve, muscle and kidney cells.
bcteo
ID:0000242
Bone marrow stromal stem cell
ID:0000242
They are known to be able to transform into liver, nerve, muscle and kidney cells.
BTO:0002668
Procedure addressed to ensure the quality of the cells. It assesses the cell source with regard to its identity/phenotype, to the presence of other cells types, adventitious agents, endogenous agents,and molecular contaminants.
bcteo
ID:0000243
Cell characterization
ID:0000243
Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male.
bcteo
ID:0000244
MG63 cell line
ID:0000244
Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male.
BTO:0001596
Biocement fabricated by using the mixed powders of magnesium oxide (MgO) and calcium dihydrogen phosphate (Ca(H2PO4)2·H2O).
bcteo
MCPB
ID:0000245
Magnesium-calcium phosphate
ID:0000245
Process that induces a non-hydrosoluble polymer to become hydrosoluble in physiological conditions.
bcteo
ID:0000246
Bioerosion
ID:0000246
Experimental environment where cells are cultured onto
the material. It describes all the biological parameters related to cell culture.
bcteo
ID:0000247
Cell culture environment
ID:0000247
Cell of a malignant neoplasm of the bone-forming tissues.
bcteo
ID:0000248
Osteosarcoma cell
ID:0000248
Material is put in the culture medium for a predefined period of time. Later cells are cultured in that medium and observed under microscope to identify possible toxic effects.
bcteo
ID:0000249
Cytotoxicity by elution test
ID:0000249
Cells are seeded onto the material and observed under microscope to identify possible toxic effects.
bcteo
ID:0000250
Direct cytotoxicity test
ID:0000250
The set of behaviors that characterize a material on its chemical-physical nature.
bcteo
ID:0000251
Biomaterial behaviour
ID:0000251
The reduction of a chemical compound to one less complex, as by splitting off one or more groups.
nci_thesaurus
ID:0000252
Degradation
ID:0000252
The reduction of a chemical compound to one less complex, as by splitting off one or more groups.
Thesaurus:C61559
Process of removal of a polymer or its degradation products through the cellular activity (phagocytosis).
bcteo
ID:0000253
Bioreabsorption
ID:0000253
releases/2013-08
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