format-version: 1.4 data-version: releases/2017-12-09 date: 09:12:17 00:00 saved-by: Frank Po-Yen Lin default-namespace: cancer_care_treatment_outcome ontology: ccto property_value: http://purl.org/dc/elements/1.1/creator "Frank Lin" xsd:string property_value: http://purl.org/dc/elements/1.1/creator "Tudor Groza" xsd:string property_value: http://purl.org/dc/elements/1.1/creator "Simon Kocbek" xsd:string property_value: http://purl.org/dc/elements/1.1/creator "Erick Antezana" xsd:string property_value: http://purl.org/dc/elements/1.1/creator "Richard Epstein" xsd:string property_value: http://purl.org/dc/elements/1.1/license "Creative Commons CC-BY 4.0" xsd:string property_value: http://purl.org/dc/elements/1.1/rights "Creative Commons CC-BY 4.0" xsd:string property_value: http://purl.org/dc/elements/1.1/subject "An ontology for cancer care (treatment outcome) in solid tumours" xsd:string [Term] id: CCTO:000001 name: All [Term] id: CCTO:000002 name: Value type is_a: CCTO:000001 ! All xref: UMLS:C1550401 [Term] id: CCTO:000003 name: Duration is_a: CCTO:000002 ! Value type xref: UMLS:C0449238 [Term] id: CCTO:000004 name: Probability is_a: CCTO:000002 ! Value type xref: UMLS:C0033204 [Term] id: CCTO:000005 name: Timed probability is_a: CCTO:000004 ! Probability [Term] id: CCTO:000006 name: Event state is_a: CCTO:000002 ! Value type [Term] id: CCTO:000007 name: Relationship operator is_a: CCTO:000001 ! All [Term] id: CCTO:000008 name: has_value_type def: "The concept has value type X" synonym: "Has value type" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000009 name: is_assessed_by def: "The concept is assessed by X" synonym: "Is assessed by" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000010 name: is_opposite_of def: "The concept is opposite of X" synonym: "Is opposite of" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000011 name: is_timed_observation_of def: "The concept is timed observation of X" synonym: "Is timed observation of" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000012 name: is_duration_of def: "The concept is duration of X" synonym: "Is duration of" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000013 name: is_probability_of def: "The concept is probability of X" synonym: "Is probability of" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000014 name: has_nominal_value def: "The concept has nominal value X" synonym: "Has nominal value" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000015 name: has_canonical_value def: "The concept has canonical value X" synonym: "Has canonical value" [] is_a: CCTO:000007 ! Relationship operator [Term] id: CCTO:000016 name: Concept domain is_a: CCTO:000001 ! All [Term] id: CCTO:000017 name: Physical health-related concept is_a: CCTO:000016 ! Concept domain [Term] id: CCTO:000018 name: Neurocognitive function property_value: schema "event_t CCTO:000018(time_t t0) = EVENT_STATE(CCTO:000018, t0)" xsd:string ! schema event_t ''Neurocognitive function''(time_t t0) = EVENT_STATE(''Neurocognitive function'', t0) is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000020 ! is_assessed_by Measure of neurocognitive function relationship: CCTO:000009 CCTO:000259 ! is_assessed_by Cognitive function [Term] id: CCTO:000019 name: Measure of concept is_a: CCTO:000001 ! All [Term] id: CCTO:000020 name: Measure of neurocognitive function is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000021 name: Psychosocial health-related concept def: "mental health status." [NCIT:C16839] synonym: "Psychological health" EXACT [NCIT:C16839] xref: UMLS:C0025353 xref: NCIT:C16839 is_a: CCTO:000016 ! Concept domain [Term] id: CCTO:000022 name: Quality of life def: "The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness." [NCIT:C17047] comment: QLQ C30; EORTC QLQ-C30 synonym: "Life quality" [] synonym: "Patient quality of life" [] synonym: "QOL" EXACT [NCIT:C17047] synonym: "Quality of life measures" [] synonym: "Quality-of-Life" EXACT [NCIT:C17047] xref: UMLS:C0518214 xref: UMLS:C0034380 xref: NCIT:C17047 property_value: schema "type_t CCTO:000022(time_t t0) = EVENT_STATE(CCTO:000022, t0)" xsd:string ! schema type_t ''Quality of life''(time_t t0) = EVENT_STATE(''Quality of life'', t0) is_a: CCTO:000021 ! Psychosocial health-related concept relationship: CCTO:000009 CCTO:000023 ! is_assessed_by Measure of quality of life relationship: CCTO:000009 CCTO:000084 ! is_assessed_by Health-related quality of life relationship: CCTO:000009 CCTO:000194 ! is_assessed_by Quality of life questionnaire relationship: CCTO:000009 CCTO:000228 ! is_assessed_by Dermatology Life Quality Index relationship: CCTO:000009 CCTO:000251 ! is_assessed_by Postoperative quality of life relationship: CCTO:000009 CCTO:000261 ! is_assessed_by Patient-reported quality of life relationship: CCTO:000009 CCTO:000263 ! is_assessed_by Expanded Prostate Cancer Index Composite relationship: CCTO:000009 CCTO:000304 ! is_assessed_by Quality adjusted life years relationship: CCTO:000009 CCTO:000348 ! is_assessed_by EORTC QLQ-C30 questionnaire [Term] id: CCTO:000023 name: Measure of quality of life is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000024 name: Health service-related concept synonym: "Health service concepts" [] is_a: CCTO:000016 ! Concept domain [Term] id: CCTO:000025 name: Patient satisfaction property_value: schema "event_t CCTO:000025(time_t t0) = EVENT_STATE(CCTO:000025, t0)" xsd:string ! schema event_t ''Patient satisfaction''(time_t t0) = EVENT_STATE(''Patient satisfaction'', t0) is_a: CCTO:000024 ! Health service-related concept xref: UMLS:C0030702 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000026 ! is_assessed_by Measure of patient satisfaction relationship: CCTO:000009 CCTO:000306 ! is_assessed_by Subject Satisfaction Score [Term] id: CCTO:000026 name: Measure of patient satisfaction is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000027 name: Patient preference property_value: schema "event_t CCTO:000027(time_t t0) = EVENT_STATE(CCTO:000027, t0)" xsd:string ! schema event_t ''Patient preference''(time_t t0) = EVENT_STATE(''Patient preference'', t0) is_a: CCTO:000024 ! Health service-related concept xref: UMLS:C0376409 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000028 ! is_assessed_by Measure of patient preference [Term] id: CCTO:000028 name: Measure of patient preference is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000029 name: Cancer treatment-related concept is_a: CCTO:000016 ! Concept domain [Term] id: CCTO:000030 name: Efficacy def: "The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials." [NCIT:C39547] synonym: "Clinical efficacy" [] synonym: "Clinical outcomes" [] synonym: "Treatment efficacy" EXACT [NCIT:C39547] xref: UMLS:C0087113 xref: UMLS:C1280519 xref: UMLS:C1707887 xref: UMLS:C3850123 xref: NCIT:C39547 property_value: schema "type_t CCTO:000030(time_t t0) = EVENT_STATE(CCTO:000030, t0)" xsd:string ! schema type_t ''Efficacy''(time_t t0) = EVENT_STATE(''Efficacy'', t0) is_a: CCTO:000029 ! Cancer treatment-related concept relationship: CCTO:000009 CCTO:000031 ! is_assessed_by Measure of efficacy relationship: CCTO:000009 CCTO:000062 ! is_assessed_by Overall survival relationship: CCTO:000009 CCTO:000063 ! is_assessed_by Progression-free survival relationship: CCTO:000009 CCTO:000064 ! is_assessed_by Disease progression relationship: CCTO:000009 CCTO:000065 ! is_assessed_by Treatment response relationship: CCTO:000009 CCTO:000066 ! is_assessed_by Duration of response relationship: CCTO:000009 CCTO:000067 ! is_assessed_by Time to progression relationship: CCTO:000009 CCTO:000068 ! is_assessed_by Overall response rate relationship: CCTO:000009 CCTO:000069 ! is_assessed_by Disease-free survival relationship: CCTO:000009 CCTO:000071 ! is_assessed_by Event-free survival relationship: CCTO:000009 CCTO:000073 ! is_assessed_by Disease Control relationship: CCTO:000009 CCTO:000074 ! is_assessed_by Disease Control Rate relationship: CCTO:000009 CCTO:000075 ! is_assessed_by Treatment failure relationship: CCTO:000009 CCTO:000076 ! is_assessed_by Time to treatment failure relationship: CCTO:000009 CCTO:000077 ! is_assessed_by Time to response relationship: CCTO:000009 CCTO:000078 ! is_assessed_by Clinical benefit relationship: CCTO:000009 CCTO:000079 ! is_assessed_by Clinical benefit rate relationship: CCTO:000009 CCTO:000080 ! is_assessed_by Relapse-free survival relationship: CCTO:000009 CCTO:000081 ! is_assessed_by Relapse relationship: CCTO:000009 CCTO:000082 ! is_assessed_by Complete response relationship: CCTO:000009 CCTO:000083 ! is_assessed_by Complete response rate relationship: CCTO:000009 CCTO:000085 ! is_assessed_by Overall survival rate relationship: CCTO:000009 CCTO:000086 ! is_assessed_by Recurrence-free survival relationship: CCTO:000009 CCTO:000087 ! is_assessed_by Recurrence relationship: CCTO:000009 CCTO:000088 ! is_assessed_by Pathologic complete response relationship: CCTO:000009 CCTO:000089 ! is_assessed_by Best overall response relationship: CCTO:000009 CCTO:000091 ! is_assessed_by Progression-free survival rate relationship: CCTO:000009 CCTO:000092 ! is_assessed_by Clinical response relationship: CCTO:000009 CCTO:000093 ! is_assessed_by Clinical response rate relationship: CCTO:000009 CCTO:000094 ! is_assessed_by Failure-free survival relationship: CCTO:000009 CCTO:000095 ! is_assessed_by Best overall response rate relationship: CCTO:000009 CCTO:000096 ! is_assessed_by Mortality relationship: CCTO:000009 CCTO:000097 ! is_assessed_by Time to recurrence relationship: CCTO:000009 CCTO:000099 ! is_assessed_by Stable disease relationship: CCTO:000009 CCTO:000100 ! is_assessed_by Duration of stable disease relationship: CCTO:000009 CCTO:000101 ! is_assessed_by R0 resection relationship: CCTO:000009 CCTO:000102 ! is_assessed_by R0 resection rate relationship: CCTO:000009 CCTO:000103 ! is_assessed_by PSA progression relationship: CCTO:000009 CCTO:000104 ! is_assessed_by Time to PSA progression relationship: CCTO:000009 CCTO:000105 ! is_assessed_by Disease-specific survival relationship: CCTO:000009 CCTO:000106 ! is_assessed_by Local control relationship: CCTO:000009 CCTO:000108 ! is_assessed_by Immune response relationship: CCTO:000009 CCTO:000109 ! is_assessed_by Recurrence rate relationship: CCTO:000009 CCTO:000111 ! is_assessed_by Radiographic progression-free survival relationship: CCTO:000009 CCTO:000112 ! is_assessed_by Radiographic progression relationship: CCTO:000009 CCTO:000114 ! is_assessed_by Death relationship: CCTO:000009 CCTO:000115 ! is_assessed_by Metastasis-free survival relationship: CCTO:000009 CCTO:000116 ! is_assessed_by Next treatment relationship: CCTO:000009 CCTO:000117 ! is_assessed_by Time to next treatment relationship: CCTO:000009 CCTO:000119 ! is_assessed_by Local control rate relationship: CCTO:000009 CCTO:000120 ! is_assessed_by PSA response relationship: CCTO:000009 CCTO:000122 ! is_assessed_by Distant disease-free survival relationship: CCTO:000009 CCTO:000125 ! is_assessed_by Duration of disease control relationship: CCTO:000009 CCTO:000126 ! is_assessed_by Relapse rate relationship: CCTO:000009 CCTO:000127 ! is_assessed_by Pathologic complete response rate relationship: CCTO:000009 CCTO:000130 ! is_assessed_by Pain progression relationship: CCTO:000009 CCTO:000131 ! is_assessed_by Time to pain progression relationship: CCTO:000009 CCTO:000132 ! is_assessed_by PSA response rate relationship: CCTO:000009 CCTO:000133 ! is_assessed_by Clinical benefit response relationship: CCTO:000009 CCTO:000134 ! is_assessed_by Remission relationship: CCTO:000009 CCTO:000135 ! is_assessed_by Duration of remission relationship: CCTO:000009 CCTO:000138 ! is_assessed_by Invasive disease-free survival relationship: CCTO:000009 CCTO:000140 ! is_assessed_by Time to relapse relationship: CCTO:000009 CCTO:000143 ! is_assessed_by Disease free survival rate relationship: CCTO:000009 CCTO:000144 ! is_assessed_by Progression-free relationship: CCTO:000009 CCTO:000146 ! is_assessed_by Local progression-free survival relationship: CCTO:000009 CCTO:000147 ! is_assessed_by Local progression relationship: CCTO:000009 CCTO:000148 ! is_assessed_by Pathological response relationship: CCTO:000009 CCTO:000149 ! is_assessed_by Pathological response rate relationship: CCTO:000009 CCTO:000153 ! is_assessed_by Local recurrence relationship: CCTO:000009 CCTO:000154 ! is_assessed_by Local recurrence rate relationship: CCTO:000009 CCTO:000155 ! is_assessed_by Complete resection relationship: CCTO:000009 CCTO:000156 ! is_assessed_by Complete resection rate relationship: CCTO:000009 CCTO:000159 ! is_assessed_by Radiographic response relationship: CCTO:000009 CCTO:000160 ! is_assessed_by Duration of clinical benefit relationship: CCTO:000009 CCTO:000162 ! is_assessed_by Local recurrence-free survival relationship: CCTO:000009 CCTO:000163 ! is_assessed_by Resection relationship: CCTO:000009 CCTO:000164 ! is_assessed_by Resection rate relationship: CCTO:000009 CCTO:000165 ! is_assessed_by Progression-free rate relationship: CCTO:000009 CCTO:000167 ! is_assessed_by Time to first skeletal-related event relationship: CCTO:000009 CCTO:000168 ! is_assessed_by Recurrence-free relationship: CCTO:000009 CCTO:000169 ! is_assessed_by Cosmetic outcome relationship: CCTO:000009 CCTO:000170 ! is_assessed_by Time to local recurrence relationship: CCTO:000009 CCTO:000171 ! is_assessed_by Local-regional control relationship: CCTO:000009 CCTO:000173 ! is_assessed_by Duration of PSA response relationship: CCTO:000009 CCTO:000174 ! is_assessed_by Clinical progression-free survival relationship: CCTO:000009 CCTO:000175 ! is_assessed_by Clinical progression relationship: CCTO:000009 CCTO:000176 ! is_assessed_by Duration of complete response relationship: CCTO:000009 CCTO:000178 ! is_assessed_by Pain response relationship: CCTO:000009 CCTO:000181 ! is_assessed_by Symptomatic progression relationship: CCTO:000009 CCTO:000182 ! is_assessed_by Time to symptomatic progression relationship: CCTO:000009 CCTO:000183 ! is_assessed_by Progression rate relationship: CCTO:000009 CCTO:000186 ! is_assessed_by Complete clearance relationship: CCTO:000009 CCTO:000187 ! is_assessed_by Complete clearance rate relationship: CCTO:000009 CCTO:000189 ! is_assessed_by Distant failure-free survival relationship: CCTO:000009 CCTO:000190 ! is_assessed_by Distant failure relationship: CCTO:000009 CCTO:000193 ! is_assessed_by Overall remission rate relationship: CCTO:000009 CCTO:000195 ! is_assessed_by Immune-related progression-free survival relationship: CCTO:000009 CCTO:000196 ! is_assessed_by Immune-related progression relationship: CCTO:000009 CCTO:000197 ! is_assessed_by Resectability relationship: CCTO:000009 CCTO:000198 ! is_assessed_by Resectability rate relationship: CCTO:000009 CCTO:000199 ! is_assessed_by Breast conservation relationship: CCTO:000009 CCTO:000200 ! is_assessed_by Breast conservation rate relationship: CCTO:000009 CCTO:000201 ! is_assessed_by Partial response relationship: CCTO:000009 CCTO:000202 ! is_assessed_by Time to clinical progression relationship: CCTO:000009 CCTO:000203 ! is_assessed_by Time to best response relationship: CCTO:000009 CCTO:000204 ! is_assessed_by Partial clearance relationship: CCTO:000009 CCTO:000205 ! is_assessed_by Partial clearance rate relationship: CCTO:000009 CCTO:000206 ! is_assessed_by Deterioration relationship: CCTO:000009 CCTO:000207 ! is_assessed_by Time to deterioration relationship: CCTO:000009 CCTO:000208 ! is_assessed_by Event-free survival rate relationship: CCTO:000009 CCTO:000210 ! is_assessed_by Locoregional failure-free survival relationship: CCTO:000009 CCTO:000211 ! is_assessed_by Locoregional failure relationship: CCTO:000009 CCTO:000213 ! is_assessed_by Tumor markers relationship: CCTO:000009 CCTO:000214 ! is_assessed_by Distant recurrence-free relationship: CCTO:000009 CCTO:000215 ! is_assessed_by Distant recurrence relationship: CCTO:000009 CCTO:000216 ! is_assessed_by Distant recurrence-free interval relationship: CCTO:000009 CCTO:000218 ! is_assessed_by Disease-free relationship: CCTO:000009 CCTO:000219 ! is_assessed_by Disease-free interval relationship: CCTO:000009 CCTO:000220 ! is_assessed_by Partial response rate relationship: CCTO:000009 CCTO:000221 ! is_assessed_by Stable disease rate relationship: CCTO:000009 CCTO:000222 ! is_assessed_by Treatment-free survival relationship: CCTO:000009 CCTO:000224 ! is_assessed_by Prostate cancer-specific survival relationship: CCTO:000009 CCTO:000232 ! is_assessed_by Time to event relationship: CCTO:000009 CCTO:000233 ! is_assessed_by PSA progression free survival relationship: CCTO:000009 CCTO:000234 ! is_assessed_by Biochemical progression-free survival relationship: CCTO:000009 CCTO:000235 ! is_assessed_by Biochemical progression relationship: CCTO:000009 CCTO:000236 ! is_assessed_by Clinical complete response relationship: CCTO:000009 CCTO:000237 ! is_assessed_by Durable response relationship: CCTO:000009 CCTO:000238 ! is_assessed_by Durable response rate relationship: CCTO:000009 CCTO:000239 ! is_assessed_by Circulating tumor cells relationship: CCTO:000009 CCTO:000240 ! is_assessed_by Time to distant metastasis relationship: CCTO:000009 CCTO:000241 ! is_assessed_by Time to local progression relationship: CCTO:000009 CCTO:000243 ! is_assessed_by Local relapse-free survival relationship: CCTO:000009 CCTO:000244 ! is_assessed_by Local relapse relationship: CCTO:000009 CCTO:000249 ! is_assessed_by Mortality rate relationship: CCTO:000009 CCTO:000252 ! is_assessed_by Initiation of Cytotoxic Chemotherapy relationship: CCTO:000009 CCTO:000253 ! is_assessed_by Time to Initiation of Cytotoxic Chemotherapy relationship: CCTO:000009 CCTO:000255 ! is_assessed_by Locoregional control rate relationship: CCTO:000009 CCTO:000256 ! is_assessed_by Hematologic improvement relationship: CCTO:000009 CCTO:000257 ! is_assessed_by Pain relief relationship: CCTO:000009 CCTO:000258 ! is_assessed_by Relapse-free survival rate relationship: CCTO:000009 CCTO:000265 ! is_assessed_by Biochemical response relationship: CCTO:000009 CCTO:000266 ! is_assessed_by Symptoms improvement relationship: CCTO:000009 CCTO:000270 ! is_assessed_by Symptomatic skeletal event relationship: CCTO:000009 CCTO:000271 ! is_assessed_by Time to first symptomatic skeletal event relationship: CCTO:000009 CCTO:000273 ! is_assessed_by Time to first flatus relationship: CCTO:000009 CCTO:000275 ! is_assessed_by Distant recurrence-free survival relationship: CCTO:000009 CCTO:000277 ! is_assessed_by Clinical tumor regression relationship: CCTO:000009 CCTO:000278 ! is_assessed_by Lymph node response relationship: CCTO:000009 CCTO:000279 ! is_assessed_by Lymph node response rate relationship: CCTO:000009 CCTO:000281 ! is_assessed_by Sphincter preservation relationship: CCTO:000009 CCTO:000282 ! is_assessed_by Sphincter preservation rate relationship: CCTO:000009 CCTO:000283 ! is_assessed_by Time to distant failure relationship: CCTO:000009 CCTO:000286 ! is_assessed_by Analgesic consumption relationship: CCTO:000009 CCTO:000289 ! is_assessed_by Radiographic response rate relationship: CCTO:000009 CCTO:000290 ! is_assessed_by Breast cancer-free relationship: CCTO:000009 CCTO:000291 ! is_assessed_by Breast cancer relationship: CCTO:000009 CCTO:000292 ! is_assessed_by Breast cancer-free interval relationship: CCTO:000009 CCTO:000293 ! is_assessed_by Time to distant recurrence relationship: CCTO:000009 CCTO:000295 ! is_assessed_by Biochemical control relationship: CCTO:000009 CCTO:000296 ! is_assessed_by Serum PSA relationship: CCTO:000009 CCTO:000298 ! is_assessed_by Biochemical relapse-free survival relationship: CCTO:000009 CCTO:000299 ! is_assessed_by Biochemical relapse relationship: CCTO:000009 CCTO:000300 ! is_assessed_by PSA doubling time relationship: CCTO:000009 CCTO:000301 ! is_assessed_by Regional recurrence free survival relationship: CCTO:000009 CCTO:000303 ! is_assessed_by Biochemical response rate relationship: CCTO:000009 CCTO:000315 ! is_assessed_by Symptomatic skeletal event free survival relationship: CCTO:000009 CCTO:000316 ! is_assessed_by Biochemical disease-free survival relationship: CCTO:000009 CCTO:000317 ! is_assessed_by Local failure relationship: CCTO:000009 CCTO:000318 ! is_assessed_by Local failure rate relationship: CCTO:000009 CCTO:000323 ! is_assessed_by Time to local failure relationship: CCTO:000009 CCTO:000327 ! is_assessed_by CNS progression relationship: CCTO:000009 CCTO:000328 ! is_assessed_by Time to CNS progression relationship: CCTO:000009 CCTO:000329 ! is_assessed_by Time to PSA response relationship: CCTO:000009 CCTO:000330 ! is_assessed_by Relapse Related Mortality relationship: CCTO:000009 CCTO:000331 ! is_assessed_by Bone marrow response relationship: CCTO:000009 CCTO:000332 ! is_assessed_by Stent patency relationship: CCTO:000009 CCTO:000335 ! is_assessed_by Time to radiographic progression relationship: CCTO:000009 CCTO:000336 ! is_assessed_by Untreatable progression relationship: CCTO:000009 CCTO:000337 ! is_assessed_by Time to untreatable progression relationship: CCTO:000009 CCTO:000338 ! is_assessed_by Breast cancer specific survival relationship: CCTO:000009 CCTO:000339 ! is_assessed_by Time to skeletal-related event relationship: CCTO:000009 CCTO:000340 ! is_assessed_by Pain control relationship: CCTO:000009 CCTO:000342 ! is_assessed_by Biological progression-free relationship: CCTO:000009 CCTO:000343 ! is_assessed_by Biological progression-free interval relationship: CCTO:000009 CCTO:000344 ! is_assessed_by Immune-related objective response relationship: CCTO:000009 CCTO:000345 ! is_assessed_by Immune-related objective response rate relationship: CCTO:000009 CCTO:000346 ! is_assessed_by Long term survival relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors relationship: CCTO:000009 CCTO:000351 ! is_assessed_by Disease clearance relationship: CCTO:000009 CCTO:001104 ! is_assessed_by Regional recurrence relationship: CCTO:000009 CCTO:001111 ! is_assessed_by Biological Progression relationship: CCTO:000009 CCTO:001131 ! is_assessed_by Locoregional recurrence relationship: CCTO:000009 CCTO:001133 ! is_assessed_by Regional control [Term] id: CCTO:000031 name: Measure of efficacy is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000032 name: Nutritional status def: "The state of the body as influenced by the diet and the ability of the diet to maintain an overall healthy condition." [NCIT:C17993] xref: UMLS:C0392209 xref: NCIT:C17993 property_value: schema "event_t CCTO:000032(time_t t0) = EVENT_STATE(CCTO:000032, t0)" xsd:string ! schema event_t ''Nutritional status''(time_t t0) = EVENT_STATE(''Nutritional status'', t0) is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000033 ! is_assessed_by Measure of nutritional status relationship: CCTO:000009 CCTO:000141 ! is_assessed_by Body Mass Index relationship: CCTO:000009 CCTO:000209 ! is_assessed_by Weight relationship: CCTO:000009 CCTO:000288 ! is_assessed_by Muscle strength [Term] id: CCTO:000033 name: Measure of nutritional status is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000034 name: Healthcare resource utilization def: "A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to healthcare resource utilization." [NCIT:C49589] synonym: "HU" EXACT [NCIT:C49589] synonym: "Healthcare resource utilization domain" EXACT [NCIT:C49589] synonym: "Resource utilization" [] xref: UMLS:C1704738 xref: NCIT:C49589 property_value: schema "unknown_t CCTO:000034(time_t t0) = EVENT_STATE(CCTO:000034, t0)" xsd:string ! schema unknown_t ''Healthcare Resource Utilization''(time_t t0) = EVENT_STATE(''Healthcare Resource Utilization'', t0) is_a: CCTO:000024 ! Health service-related concept relationship: CCTO:000009 CCTO:000035 ! is_assessed_by Measure of healthcare resource utilization relationship: CCTO:000009 CCTO:000113 ! is_assessed_by Length of hospital stay relationship: CCTO:000009 CCTO:000150 ! is_assessed_by Hospital stay relationship: CCTO:000009 CCTO:000158 ! is_assessed_by Operative time relationship: CCTO:000009 CCTO:000294 ! is_assessed_by Length of postoperative hospital stay relationship: CCTO:000009 CCTO:000309 ! is_assessed_by Readmission relationship: CCTO:000009 CCTO:000310 ! is_assessed_by Readmission rate relationship: CCTO:000009 CCTO:000321 ! is_assessed_by Postoperative hospital stay [Term] id: CCTO:000035 name: Measure of healthcare resource utilization is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000036 name: Performance status def: "A measure of how well a patient is able to perform ordinary tasks and carry out daily activities." [NCIT:C20641] xref: UMLS:C1518965 xref: NCIT:C20641 property_value: schema "type_t CCTO:000036(time_t t0) = EVENT_STATE(CCTO:000036, t0)" xsd:string ! schema type_t ''Performance Status''(time_t t0) = EVENT_STATE(''Performance Status'', t0) is_a: CCTO:000021 ! Psychosocial health-related concept relationship: CCTO:000009 CCTO:000037 ! is_assessed_by Measure of performance status relationship: CCTO:000009 CCTO:000123 ! is_assessed_by Morbidity relationship: CCTO:000009 CCTO:000191 ! is_assessed_by Surgical morbidity relationship: CCTO:000009 CCTO:000192 ! is_assessed_by Karnofsky Performance Status relationship: CCTO:000009 CCTO:000247 ! is_assessed_by Perioperative morbidity relationship: CCTO:000009 CCTO:000250 ! is_assessed_by Activities of daily living relationship: CCTO:000009 CCTO:000288 ! is_assessed_by Muscle strength relationship: CCTO:000009 CCTO:000297 ! is_assessed_by Physical Function relationship: CCTO:000009 CCTO:000302 ! is_assessed_by ECOG performance status [Term] id: CCTO:000037 name: Measure of performance status is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000038 name: Sexual function def: "The bodily processes that include arousal, erection, orgasm, and ejaculation." [NCIT:C118256] xref: UMLS:C0278092 xref: NCIT:C118256 property_value: schema "event_t CCTO:000038(time_t t0) = EVENT_STATE(CCTO:000038, t0)" xsd:string ! schema event_t ''Sexual function''(time_t t0) = EVENT_STATE(''Sexual function'', t0) is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000039 ! is_assessed_by Measure of sexual function relationship: CCTO:000009 CCTO:000262 ! is_assessed_by Residual erectile function relationship: CCTO:000009 CCTO:000308 ! is_assessed_by Sexuality problems relationship: CCTO:000009 CCTO:000311 ! is_assessed_by Intimacy problems relationship: CCTO:000009 CCTO:000313 ! is_assessed_by Erectile function relationship: CCTO:000009 CCTO:000913 ! is_assessed_by Anorgasmia relationship: CCTO:000009 CCTO:000915 ! is_assessed_by Delayed orgasm relationship: CCTO:000009 CCTO:000954 ! is_assessed_by Erectile dysfunction [Term] id: CCTO:000039 name: Measure of sexual function is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000040 name: Costs def: "The amount of money needed to buy, do or make something OR The amount paid, charged, or engaged to be paid, for purchasing goods, services and financial instruments." [NCIT:C16471, NCIT:C69088] synonym: "Cost" EXACT [NCIT:C16471] synonym: "Cost" EXACT [NCIT:C69088] synonym: "Health care costs" [] synonym: "Treatment costs" [] xref: UMLS:C0010186 xref: UMLS:C0087112 xref: UMLS:C0085552 xref: NCIT:C16471 xref: NCIT:C69088 property_value: schema "event_t CCTO:000040(time_t t0) = EVENT_STATE(CCTO:000040, t0)" xsd:string ! schema event_t ''Costs''(time_t t0) = EVENT_STATE(''Costs'', t0) is_a: CCTO:000024 ! Health service-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000041 ! is_assessed_by Measure of costs [Term] id: CCTO:000041 name: Measure of costs is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000042 name: Safety def: "The state of being certain that adverse effects will not be caused by some agent under defined conditions." [NCIT:C60828] comment: adverse events synonym: "Overall safety" [] synonym: "Safety parameters" [] synonym: "Safety endpoints" [] synonym: "Safety measures" [] xref: UMLS:C0036043 xref: UMLS:C1705187 xref: NCIT:C60828 property_value: schema "type_t CCTO:000042(time_t t0) = EVENT_STATE(CCTO:000042, t0)" xsd:string ! schema type_t ''Safety''(time_t t0) = EVENT_STATE(''Safety'', t0) is_a: CCTO:000029 ! Cancer treatment-related concept relationship: CCTO:000009 CCTO:000043 ! is_assessed_by Measure of safety relationship: CCTO:000009 CCTO:000048 ! is_assessed_by Toxicity relationship: CCTO:000009 CCTO:000072 ! is_assessed_by Event relationship: CCTO:000009 CCTO:000075 ! is_assessed_by Treatment failure relationship: CCTO:000009 CCTO:000076 ! is_assessed_by Time to treatment failure relationship: CCTO:000009 CCTO:000090 ! is_assessed_by Treatment-related mortality relationship: CCTO:000009 CCTO:000096 ! is_assessed_by Mortality relationship: CCTO:000009 CCTO:000107 ! is_assessed_by Pain relationship: CCTO:000009 CCTO:000110 ! is_assessed_by Side effects relationship: CCTO:000009 CCTO:000114 ! is_assessed_by Death relationship: CCTO:000009 CCTO:000116 ! is_assessed_by Next treatment relationship: CCTO:000009 CCTO:000117 ! is_assessed_by Time to next treatment relationship: CCTO:000009 CCTO:000121 ! is_assessed_by Acute toxicity relationship: CCTO:000009 CCTO:000124 ! is_assessed_by Postoperative complications relationship: CCTO:000009 CCTO:000128 ! is_assessed_by Fatigue relationship: CCTO:000009 CCTO:000129 ! is_assessed_by Infections relationship: CCTO:000009 CCTO:000130 ! is_assessed_by Pain progression relationship: CCTO:000009 CCTO:000131 ! is_assessed_by Time to pain progression relationship: CCTO:000009 CCTO:000136 ! is_assessed_by Late toxicity relationship: CCTO:000009 CCTO:000137 ! is_assessed_by Complications relationship: CCTO:000009 CCTO:000141 ! is_assessed_by Body Mass Index relationship: CCTO:000009 CCTO:000142 ! is_assessed_by Bone mineral density relationship: CCTO:000009 CCTO:000145 ! is_assessed_by Treatment related toxicity relationship: CCTO:000009 CCTO:000152 ! is_assessed_by Postoperative pain relationship: CCTO:000009 CCTO:000157 ! is_assessed_by Pain score relationship: CCTO:000009 CCTO:000161 ! is_assessed_by Complication rate relationship: CCTO:000009 CCTO:000166 ! is_assessed_by Skeletal-related event relationship: CCTO:000009 CCTO:000167 ! is_assessed_by Time to first skeletal-related event relationship: CCTO:000009 CCTO:000172 ! is_assessed_by Pain intensity relationship: CCTO:000009 CCTO:000177 ! is_assessed_by Blood loss relationship: CCTO:000009 CCTO:000178 ! is_assessed_by Pain response relationship: CCTO:000009 CCTO:000179 ! is_assessed_by Surgical complications relationship: CCTO:000009 CCTO:000180 ! is_assessed_by Hospital Anxiety and Depression Scale relationship: CCTO:000009 CCTO:000184 ! is_assessed_by Toxicity rate relationship: CCTO:000009 CCTO:000185 ! is_assessed_by Positive and Negative Affect Schedule relationship: CCTO:000009 CCTO:000188 ! is_assessed_by Depression relationship: CCTO:000009 CCTO:000209 ! is_assessed_by Weight relationship: CCTO:000009 CCTO:000212 ! is_assessed_by Erythema relationship: CCTO:000009 CCTO:000217 ! is_assessed_by Visual analogue scale relationship: CCTO:000009 CCTO:000225 ! is_assessed_by Psychological distress relationship: CCTO:000009 CCTO:000226 ! is_assessed_by Edema relationship: CCTO:000009 CCTO:000227 ! is_assessed_by Early late toxicity relationship: CCTO:000009 CCTO:000229 ! is_assessed_by Menopausal symptoms relationship: CCTO:000009 CCTO:000230 ! is_assessed_by Brief Pain Inventory relationship: CCTO:000009 CCTO:000231 ! is_assessed_by Weight loss relationship: CCTO:000009 CCTO:000242 ! is_assessed_by Endometrial thickness relationship: CCTO:000009 CCTO:000245 ! is_assessed_by Dose-limiting toxicities relationship: CCTO:000009 CCTO:000246 ! is_assessed_by Long term toxicity relationship: CCTO:000009 CCTO:000248 ! is_assessed_by Hamilton Depression Scale relationship: CCTO:000009 CCTO:000254 ! is_assessed_by Intraoperative blood loss relationship: CCTO:000009 CCTO:000257 ! is_assessed_by Pain relief relationship: CCTO:000009 CCTO:000260 ! is_assessed_by Anxiety relationship: CCTO:000009 CCTO:000262 ! is_assessed_by Residual erectile function relationship: CCTO:000009 CCTO:000264 ! is_assessed_by Hypopigmentation relationship: CCTO:000009 CCTO:000267 ! is_assessed_by Hyperpigmentation relationship: CCTO:000009 CCTO:000268 ! is_assessed_by Modified ASEPSIS Scale relationship: CCTO:000009 CCTO:000269 ! is_assessed_by Surgical Site Infection Score relationship: CCTO:000009 CCTO:000272 ! is_assessed_by Flatus relationship: CCTO:000009 CCTO:000273 ! is_assessed_by Time to first flatus relationship: CCTO:000009 CCTO:000274 ! is_assessed_by Local skin reactions relationship: CCTO:000009 CCTO:000276 ! is_assessed_by Cardiac toxicity relationship: CCTO:000009 CCTO:000280 ! is_assessed_by Postoperative mortality relationship: CCTO:000009 CCTO:000287 ! is_assessed_by Bleeding relationship: CCTO:000009 CCTO:000288 ! is_assessed_by Muscle strength relationship: CCTO:000009 CCTO:000305 ! is_assessed_by Injection site reaction relationship: CCTO:000009 CCTO:000307 ! is_assessed_by Brief Fatigue Inventory relationship: CCTO:000009 CCTO:000308 ! is_assessed_by Sexuality problems relationship: CCTO:000009 CCTO:000311 ! is_assessed_by Intimacy problems relationship: CCTO:000009 CCTO:000313 ! is_assessed_by Erectile function relationship: CCTO:000009 CCTO:000314 ! is_assessed_by Adverse event rate relationship: CCTO:000009 CCTO:000319 ! is_assessed_by Neurotoxicity relationship: CCTO:000009 CCTO:000320 ! is_assessed_by Infectious complications relationship: CCTO:000009 CCTO:000322 ! is_assessed_by Surgical site infection relationship: CCTO:000009 CCTO:000324 ! is_assessed_by Nausea and vomiting relationship: CCTO:000009 CCTO:000325 ! is_assessed_by Late complications relationship: CCTO:000009 CCTO:000326 ! is_assessed_by Infection Rate relationship: CCTO:000009 CCTO:000333 ! is_assessed_by Nausea relationship: CCTO:000009 CCTO:000334 ! is_assessed_by Bone pain relationship: CCTO:000009 CCTO:000339 ! is_assessed_by Time to skeletal-related event relationship: CCTO:000009 CCTO:000340 ! is_assessed_by Pain control relationship: CCTO:000009 CCTO:000341 ! is_assessed_by Hematologic toxicity relationship: CCTO:000009 CCTO:000361 ! is_assessed_by Lymph node pain relationship: CCTO:000009 CCTO:000371 ! is_assessed_by Chest pain - cardiac relationship: CCTO:000009 CCTO:000398 ! is_assessed_by Ear pain relationship: CCTO:000009 CCTO:000400 ! is_assessed_by External ear pain relationship: CCTO:000009 CCTO:000422 ! is_assessed_by Eye pain relationship: CCTO:000009 CCTO:000430 ! is_assessed_by Papilledema relationship: CCTO:000009 CCTO:000441 ! is_assessed_by Abdominal pain relationship: CCTO:000009 CCTO:000446 ! is_assessed_by Anal pain relationship: CCTO:000009 CCTO:000478 ! is_assessed_by Esophageal pain relationship: CCTO:000009 CCTO:000495 ! is_assessed_by Gastrointestinal pain relationship: CCTO:000009 CCTO:000497 ! is_assessed_by Gingival pain relationship: CCTO:000009 CCTO:000514 ! is_assessed_by Lip pain relationship: CCTO:000009 CCTO:000522 ! is_assessed_by Oral pain relationship: CCTO:000009 CCTO:000536 ! is_assessed_by Rectal pain relationship: CCTO:000009 CCTO:000548 ! is_assessed_by Stomach pain relationship: CCTO:000009 CCTO:000557 ! is_assessed_by Edema face relationship: CCTO:000009 CCTO:000558 ! is_assessed_by Edema limbs relationship: CCTO:000009 CCTO:000559 ! is_assessed_by Edema trunk relationship: CCTO:000009 CCTO:000560 ! is_assessed_by Facial pain relationship: CCTO:000009 CCTO:000565 ! is_assessed_by Infusion related reaction relationship: CCTO:000009 CCTO:000568 ! is_assessed_by Localized edema relationship: CCTO:000009 CCTO:000571 ! is_assessed_by Neck edema relationship: CCTO:000009 CCTO:000572 ! is_assessed_by Non-cardiac chest pain relationship: CCTO:000009 CCTO:000580 ! is_assessed_by Gallbladder pain relationship: CCTO:000009 CCTO:000585 ! is_assessed_by Hepatic pain relationship: CCTO:000009 CCTO:000589 ! is_assessed_by Allergic reaction relationship: CCTO:000009 CCTO:000715 ! is_assessed_by Postoperative thoracic procedure complication relationship: CCTO:000009 CCTO:000718 ! is_assessed_by Radiation recall reaction (dermatologic) relationship: CCTO:000009 CCTO:000739 ! is_assessed_by Vascular access complication relationship: CCTO:000009 CCTO:000741 ! is_assessed_by Wound complication relationship: CCTO:000009 CCTO:000807 ! is_assessed_by Back pain relationship: CCTO:000009 CCTO:000808 ! is_assessed_by Buttock pain relationship: CCTO:000009 CCTO:000809 ! is_assessed_by Chest wall pain relationship: CCTO:000009 CCTO:000812 ! is_assessed_by Flank pain relationship: CCTO:000009 CCTO:000830 ! is_assessed_by Neck pain relationship: CCTO:000009 CCTO:000834 ! is_assessed_by Pain in extremity relationship: CCTO:000009 CCTO:000845 ! is_assessed_by Tumor pain relationship: CCTO:000009 CCTO:000865 ! is_assessed_by Edema cerebral relationship: CCTO:000009 CCTO:000891 ! is_assessed_by Phantom pain relationship: CCTO:000009 CCTO:000898 ! is_assessed_by Sinus pain relationship: CCTO:000009 CCTO:000907 ! is_assessed_by Vasovagal reaction relationship: CCTO:000009 CCTO:000945 ! is_assessed_by Urinary tract pain relationship: CCTO:000009 CCTO:000950 ! is_assessed_by Breast pain relationship: CCTO:000009 CCTO:000954 ! is_assessed_by Erectile dysfunction relationship: CCTO:000009 CCTO:000959 ! is_assessed_by Genital edema relationship: CCTO:000009 CCTO:000969 ! is_assessed_by Ovulation pain relationship: CCTO:000009 CCTO:000971 ! is_assessed_by Pelvic pain relationship: CCTO:000009 CCTO:000972 ! is_assessed_by Penile pain relationship: CCTO:000009 CCTO:000973 ! is_assessed_by Perineal pain relationship: CCTO:000009 CCTO:000977 ! is_assessed_by Prostatic pain relationship: CCTO:000009 CCTO:000978 ! is_assessed_by Scrotal pain relationship: CCTO:000009 CCTO:000983 ! is_assessed_by Testicular pain relationship: CCTO:000009 CCTO:000987 ! is_assessed_by Uterine pain relationship: CCTO:000009 CCTO:000994 ! is_assessed_by Vaginal pain relationship: CCTO:000009 CCTO:001016 ! is_assessed_by Laryngeal edema relationship: CCTO:000009 CCTO:001031 ! is_assessed_by Pharyngolaryngeal pain relationship: CCTO:000009 CCTO:001034 ! is_assessed_by Pleuritic pain relationship: CCTO:000009 CCTO:001039 ! is_assessed_by Pulmonary edema relationship: CCTO:000009 CCTO:001058 ! is_assessed_by Erythema multiforme relationship: CCTO:000009 CCTO:001069 ! is_assessed_by Pain of skin relationship: CCTO:000009 CCTO:001071 ! is_assessed_by Periorbital edema relationship: CCTO:000009 CCTO:001077 ! is_assessed_by Scalp pain relationship: CCTO:000009 CCTO:001093 ! is_assessed_by Lymphedema relationship: CCTO:000009 CCTO:001120 ! is_assessed_by Injury, poisoning and procedural complications [Term] id: CCTO:000043 name: Measure of safety is_a: CCTO:000017 ! Physical health-related concept is_a: CCTO:000019 ! Measure of concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000044 name: Adherence def: "The act of abiding by a stated treatment plan or protocol OR The extent to which a patient conforms to medical advice regarding prescribed regimen, lifestyle, dietary changes, follow-up schedule and other recommendations." [NCIT:C25729, NCIT:C39490] synonym: "Compliance" EXACT [NCIT:C39490] synonym: "Compliant" EXACT [NCIT:C39490] synonym: "Patient compliance" EXACT [NCIT:C39490] synonym: "Treatment compliance" [] xref: UMLS:C1321605 xref: UMLS:C0009563 xref: UMLS:C3244300 xref: UMLS:C1510802 xref: UMLS:C0566588 xref: NCIT:C25729 xref: NCIT:C39490 property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000044(time_t t0) = EVENT_STATE(CCTO:000044, t0)" xsd:string ! schema event_t ''Adherence''(time_t t0) = EVENT_STATE(''Adherence'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000029 ! Cancer treatment-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000045 ! is_assessed_by Measure of adherence relationship: CCTO:000009 CCTO:000284 ! is_assessed_by Treatment completion relationship: CCTO:000009 CCTO:000285 ! is_assessed_by Treatment completion rate relationship: CCTO:000009 CCTO:000312 ! is_assessed_by Adherence rate [Term] id: CCTO:000045 name: Measure of adherence is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000046 name: Tolerability def: "A type of safety study that assesses the degree to which overt adverse effects can be tolerated by the subject." [NCIT:C98791] synonym: "Tolerability study" EXACT [NCIT:C98791] synonym: "Tolerance" [] synonym: "Treatment tolerance" [] xref: UMLS:C3274448 xref: UMLS:C0220929 xref: UMLS:C1704410 xref: UMLS:C0231197 xref: NCIT:C98791 property_value: schema "type_t CCTO:000046(time_t t0) = EVENT_STATE(CCTO:000046, t0)" xsd:string ! schema type_t ''Tolerability''(time_t t0) = EVENT_STATE(''Tolerability'', t0) is_a: CCTO:000029 ! Cancer treatment-related concept relationship: CCTO:000009 CCTO:000047 ! is_assessed_by Measure of tolerability relationship: CCTO:000009 CCTO:000285 ! is_assessed_by Treatment completion rate [Term] id: CCTO:000047 name: Measure of tolerability is_a: CCTO:000019 ! Measure of concept [Term] id: CCTO:000048 name: Toxicity def: "The finding of bodily harm due to the poisonous effects of something." [NCIT:C27990] synonym: "Overall toxicity" [] synonym: "Qualitative and quantitative toxicities" [] synonym: "TOX" EXACT [NCIT:C27990] synonym: "Toxic effects" [] synonym: "Toxicities" [] synonym: "Treatment toxicity" [] xref: UMLS:C0600688 xref: UMLS:C0040539 xref: NCIT:C27990 property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "type_t CCTO:000048(time_t t0) = EVENT_STATE(CCTO:000048, t0)" xsd:string ! schema type_t ''Toxicity''(time_t t0) = EVENT_STATE(''Toxicity'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000009 CCTO:000184 ! is_assessed_by Toxicity rate relationship: CCTO:000009 CCTO:000285 ! is_assessed_by Treatment completion rate relationship: CCTO:000009 CCTO:000314 ! is_assessed_by Adverse event rate relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000049 name: Adverse events def: "Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s)." [NCIT:C41331] synonym: "AE" EXACT [NCIT:C41331] synonym: "Adverse event" EXACT [NCIT:C41331] synonym: "Adverse experience" EXACT [NCIT:C41331] synonym: "Adverse effects" [] synonym: "AdverseEvent" EXACT [NCIT:C41331] synonym: "Other adverse events" [] xref: UMLS:C0877248 xref: UMLS:C1705413 xref: UMLS:C0001688 xref: UMLS:C0879626 xref: NCIT:C41331 property_value: ESCORT_rule "CCTO:000049 implies CCTO:000043" xsd:string ! ESCORT_rule ''Adverse events'' implies ''Measure of safety'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000049(time_t t0) = EVENT_STATE(CCTO:000049, t0)" xsd:string ! schema event_t ''Adverse events''(time_t t0) = EVENT_STATE(''Adverse events'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000042 ! is_assessed_by Safety relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000050 name: Assessment tool is_a: CCTO:000001 ! All [Term] id: CCTO:000051 name: Investigation synonym: "Investigations" [] is_a: CCTO:000050 ! Assessment tool xref: UMLS:C1261322 xref: UMLS:C1552578 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000052 name: Patient questionnaire synonym: "Patient questionnaires" [] synonym: "Questionnaire" [] synonym: "Questionnaires" [] is_a: CCTO:000050 ! Assessment tool xref: UMLS:C0034394 xref: UMLS:C1706422 [Term] id: CCTO:000053 name: Clinical criteria is_a: CCTO:000050 ! Assessment tool [Term] id: CCTO:000054 name: Treatment start synonym: "treatment-start" [] is_a: CCTO:000006 ! Event state [Term] id: CCTO:000055 name: Treatment end synonym: "treatment-end" [] is_a: CCTO:000006 ! Event state [Term] id: CCTO:000056 name: Has local disease synonym: "local disease" [] property_value: ESCORT_rule "CCTO:000056 implies CCTO:000070" xsd:string ! ESCORT_rule ''Has local disease'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000056 implies NOT CCTO:000059" xsd:string ! ESCORT_rule ''Has local disease'' implies NOT ''Local disease-free'' property_value: ESCORT_rule "CCTO:000056 implies NOT CCTO:000218" xsd:string ! ESCORT_rule ''Has local disease'' implies NOT ''Disease-free'' property_value: ESCORT_rule "NOT CCTO:000056 implies CCTO:000059" xsd:string ! ESCORT_rule NOT ''Has local disease'' implies ''Local disease-free'' is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000059 ! Local disease-free xref: UMLS:C0277565 [Term] id: CCTO:000057 name: Has regional disease def: "A disease or condition that extends beyond the site and spreads into adjacent tissues and regional lymph nodes." [NCIT:C41844] synonym: "Regional disease" EXACT [NCIT:C41844] xref: UMLS:C1514819 xref: NCIT:C41844 property_value: ESCORT_rule "CCTO:000057 implies CCTO:000070" xsd:string ! ESCORT_rule ''Has regional disease'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000057 implies NOT CCTO:000060" xsd:string ! ESCORT_rule ''Has regional disease'' implies NOT ''Regional disease-free'' property_value: ESCORT_rule "CCTO:000057 implies NOT CCTO:000218 " xsd:string ! ESCORT_rule ''Has regional disease'' implies NOT ''Disease-free'' property_value: ESCORT_rule "NOT CCTO:000057 implies CCTO:000060" xsd:string ! ESCORT_rule NOT ''Has regional disease'' implies ''Regional disease-free'' is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000060 ! Regional disease-free [Term] id: CCTO:000058 name: Has metastasis def: "A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors." [NCIT:C18206] synonym: "Distant cancer" EXACT [NCIT:C18206] synonym: "Distant metastasis" EXACT [NCIT:C18206] synonym: "Distant disease" [] synonym: "Distant metastases" [] synonym: "Metastases" [] synonym: "Metastasis" EXACT [NCIT:C19151] synonym: "Metastasize" EXACT [NCIT:C19151] synonym: "Tumor cell migration" EXACT [NCIT:C19151] xref: UMLS:C0027627 xref: UMLS:C1269798 xref: NCIT:C18206 xref: NCIT:C19151 property_value: ESCORT_rule "CCTO:000058 implies CCTO:000058" xsd:string ! ESCORT_rule ''Has metastasis'' implies ''Has metastasis'' property_value: ESCORT_rule "CCTO:000058 implies CCTO:000070" xsd:string ! ESCORT_rule ''Has metastasis'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000058 implies CCTO:000139" xsd:string ! ESCORT_rule ''Has metastasis'' implies ''Invasive disease'' property_value: ESCORT_rule "CCTO:000058 implies NOT CCTO:000061" xsd:string ! ESCORT_rule ''Has metastasis'' implies NOT ''Metastasis-free'' property_value: ESCORT_rule "CCTO:000058 implies NOT CCTO:000218" xsd:string ! ESCORT_rule ''Has metastasis'' implies NOT ''Disease-free'' property_value: ESCORT_rule "NOT CCTO:000058 implies CCTO:000061" xsd:string ! ESCORT_rule NOT ''Has metastasis'' implies ''Metastasis-free'' property_value: schema "event_t CCTO:000058(time_t t0) = EVENT_STATE(CCTO:000058, t0)" xsd:string ! schema event_t ''Has metastasis''(time_t t0) = EVENT_STATE(''Has metastasis'', t0) property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000061 ! Metastasis-free disjoint_from: CCTO:000218 ! Disease-free relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000059 name: Local disease-free property_value: ESCORT_rule "CCTO:000059 implies CCTO:000106" xsd:string ! ESCORT_rule ''Local disease-free'' implies ''Local control'' property_value: ESCORT_rule "CCTO:000059 implies NOT CCTO:000056" xsd:string ! ESCORT_rule ''Local disease-free'' implies NOT ''Has local disease'' property_value: ESCORT_rule "NOT CCTO:000059 implies CCTO:000056" xsd:string ! ESCORT_rule NOT ''Local disease-free'' implies ''Has local disease'' is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000056 ! Has local disease [Term] id: CCTO:000060 name: Regional disease-free property_value: ESCORT_rule "CCTO:000060 implies CCTO:001133" xsd:string ! ESCORT_rule ''Regional disease-free'' implies ''Regional control'' property_value: ESCORT_rule "CCTO:000060 implies NOT CCTO:000057" xsd:string ! ESCORT_rule ''Regional disease-free'' implies NOT ''Has regional disease'' property_value: ESCORT_rule "NOT CCTO:000060 implies CCTO:000057" xsd:string ! ESCORT_rule NOT ''Regional disease-free'' implies ''Has regional disease'' is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000057 ! Has regional disease [Term] id: CCTO:000061 name: Metastasis-free property_value: ESCORT_rule "CCTO:000061 implies NOT CCTO:000058" xsd:string ! ESCORT_rule ''Metastasis-free'' implies NOT ''Has metastasis'' property_value: ESCORT_rule "NOT CCTO:000061 implies CCTO:000058" xsd:string ! ESCORT_rule NOT ''Metastasis-free'' implies ''Has metastasis'' is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000058 ! Has metastasis [Term] id: CCTO:000062 name: Overall survival def: "A measure of the time until death from any cause." [NCIT:C125201] comment: OS synonym: "Duration of overall survival" [] synonym: "Duration of survival" [] synonym: "Global survival" [] synonym: "Kaplan-Meier Estimate for Overall Survival" [] synonym: "OS" [] synonym: "Over all survival" [] synonym: "Overall patient survival" [] synonym: "Overall survivals" [] synonym: "Patient survival" [] synonym: "Survival" [] synonym: "Time to death" [] xref: UMLS:C0220921 xref: UMLS:C0038952 xref: NCIT:C125201 property_value: ESCORT_rule "CCTO:000062 = time-to-first CCTO:000114" xsd:string ! ESCORT_rule ''Overall survival'' = time-to-first ''Death'' property_value: has_operator CCTO:000011 ! has_operator is_timed_observation_of property_value: schema "duration_t CCTO:000062(time_t t0) = time_to_first_event(time_t t0, CCTO:000114)" xsd:string ! schema duration_t ''Overall survival''(time_t t0) = time_to_first_event(time_t t0, ''Death'') is_a: CCTO:000003 ! duration is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000063 name: Progression-free survival comment: PFS synonym: "Composite Progression-free Survival" [] synonym: "Disease progression-free survival" [] synonym: "Duration of PFS" [] synonym: "Duration of progression-free survival" [] synonym: "Overall progression-free survival" [] synonym: "PFS" EXACT [NCIT:C28234] synonym: "Progression free survival" [] xref: UMLS:C0242792 xref: NCIT:C28234 property_value: ESCORT_rule "CCTO:000063 = time-to-first CCTO:000114 CCTO:000064" xsd:string ! ESCORT_rule ''Progression-free survival'' = time-to-first ''Death'' ''Disease progression'' property_value: has_operator CCTO:000011 ! has_operator is_timed_observation_of property_value: schema "duration_t CCTO:000063(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000064) )" xsd:string ! schema duration_t ''Progression-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Disease progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000064 name: Disease progression def: "A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a neoplasm OR A disease process that is increasing in scope or severity OR A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a malignant neoplasm OR Process of disease spreading and/or increase of its severity OR The worsening of a disease over time." [NCIT:C17609, NCIT:C35571, NCIT:C19987, NCIT:C25331, NCIT:C17747] synonym: "Cancer disease progression" EXACT [NCIT:C19987] synonym: "Cancer progression" EXACT [NCIT:C19987] synonym: "Overall progression" [] synonym: "Progression" EXACT [NCIT:C17747] synonym: "Progression" EXACT [NCIT:C25331] synonym: "Progressive disease" EXACT [NCIT:C35571] synonym: "Progressive neoplastic disease" EXACT [NCIT:C8510] synonym: "Tumor progression" EXACT [NCIT:C17609] synonym: "progression of disease" [] synonym: "tumour progression" [] xref: UMLS:C0242656 xref: UMLS:C0178874 xref: UMLS:C1947901 xref: UMLS:C1335499 xref: UMLS:C0677932 xref: UMLS:C3539781 xref: NCIT:C17609 xref: NCIT:C17747 xref: NCIT:C19987 xref: NCIT:C25331 xref: NCIT:C35571 xref: NCIT:C8510 property_value: ESCORT_rule "CCTO:000064 globally-implies CCTO:000064" xsd:string ! ESCORT_rule ''Disease progression'' globally-implies ''Disease progression'' property_value: ESCORT_rule "CCTO:000064 implies CCTO:000070" xsd:string ! ESCORT_rule ''Disease progression'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000065" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Treatment response'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000073" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Disease Control'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000078" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Clinical benefit'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000082" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Complete response'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000099" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Stable disease'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000144" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Progression-free'' property_value: ESCORT_rule "CCTO:000064 implies NOT CCTO:000201" xsd:string ! ESCORT_rule ''Disease progression'' implies NOT ''Partial response'' property_value: ESCORT_rule "NOT CCTO:000064 implies CCTO:000073" xsd:string ! ESCORT_rule NOT ''Disease progression'' implies ''Disease Control'' property_value: ESCORT_rule "NOT CCTO:000064 implies CCTO:000144" xsd:string ! ESCORT_rule NOT ''Disease progression'' implies ''Progression-free'' property_value: schema "event_t CCTO:000064(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000064, t0, assessed_at)" xsd:string ! schema event_t ''Disease progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Disease progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000065 ! Treatment response disjoint_from: CCTO:000073 ! Disease Control disjoint_from: CCTO:000082 ! Complete response disjoint_from: CCTO:000099 ! Stable disease disjoint_from: CCTO:000144 ! Progression-free disjoint_from: CCTO:000201 ! Partial response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors relationship: CCTO:000010 CCTO:000144 ! is_opposite_of Progression-free [Term] id: CCTO:000065 name: Treatment response def: "An assessment of the overall response of the disease to the therapy." [NCIT:C96613] synonym: "Anti-tumor response" [] synonym: "Confirmed response" [] synonym: "Disease response" [] synonym: "OVRLRESP" EXACT [NCIT:C96613] synonym: "Objective response" [] synonym: "Objective overall response" [] synonym: "Objective tumor response" [] synonym: "Overall objective response" [] synonym: "Overall response" EXACT [NCIT:C96613] synonym: "Overall tumor response" [] synonym: "Patient response" [] synonym: "Response to chemotherapy" [] synonym: "Response to therapy" [] synonym: "Response to treatment" [] synonym: "Response" [] synonym: "Tumor shrinkage" [] synonym: "Tumor response" [] synonym: "Tumoral response" [] synonym: "Tumour shrinkage" [] synonym: "Tumour response" [] xref: UMLS:C3272903 xref: UMLS:C0521982 xref: UMLS:C1704632 xref: UMLS:C1706817 xref: NCIT:C96613 property_value: ESCORT_rule "CCTO:000065 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Treatment response'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000065 implies NOT CCTO:000099" xsd:string ! ESCORT_rule ''Treatment response'' implies NOT ''Stable disease'' property_value: ESCORT_rule "CCTO:000065 is-union-of CCTO:000082 CCTO:000201" xsd:string ! ESCORT_rule ''Treatment response'' is-union-of ''Complete response'' ''Partial response'' property_value: ESCORT_rule "CCTO:000082 implies CCTO:000065" xsd:string ! ESCORT_rule ''Complete response'' implies ''Treatment response'' property_value: ESCORT_rule "CCTO:000201 implies CCTO:000065" xsd:string ! ESCORT_rule ''Partial response'' implies ''Treatment response'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: schema "event_t CCTO:000065(time_t t0, time_t assessed_at) = CCTO:000082(t0, assessed_at) OR CCTO:000201(t0, assessed_at)" xsd:string ! schema event_t ''Treatment response''(time_t t0, time_t assessed_at) = ''Complete response''(t0, assessed_at) OR ''Partial response''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy union_of: CCTO:000082 ! Complete response union_of: CCTO:000201 ! Partial response disjoint_from: CCTO:000064 ! Disease progression disjoint_from: CCTO:000099 ! Stable disease relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors [Term] id: CCTO:000066 name: Duration of response synonym: "Duration of objective response" [] synonym: "Duration of overall response" [] synonym: "Duration of tumor response" [] synonym: "Overall response duration" [] synonym: "Response duration" [] property_value: schema "duration_t CCTO:000066(time_t t0) = duration_of_event(CCTO:000065, t0)" xsd:string ! schema duration_t ''Duration of response''(time_t t0) = duration_of_event(''Treatment response'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy xref: UMLS:C0237585 relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000065 ! is_duration_of Treatment response [Term] id: CCTO:000067 name: Time to progression comment: TTP synonym: "Progression-free interval" [] synonym: "TTP" EXACT [NCIT:C93153] synonym: "Time to Progressive Disease" [] synonym: "Time to Tumor Progression" [] synonym: "Time to disease progression" [] synonym: "Time to progression of disease" [] synonym: "Time to tumour progression" [] xref: UMLS:C2985467 xref: UMLS:C3539814 xref: UMLS:C0034155 xref: NCIT:C93153 property_value: ESCORT_rule "CCTO:000067 = time-to-first CCTO:000064" xsd:string ! ESCORT_rule ''Time to progression'' = time-to-first ''Disease progression'' property_value: schema "duration_t CCTO:000067(time_t t0) = time_to_first_event(CCTO:000064, t0)" xsd:string ! schema duration_t ''Time to progression''(time_t t0) = time_to_first_event(''Disease progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000068 name: Overall response rate comment: ORR; CR + PR; complete and partial response; Complete and Partial Response; CR+PR; complete and partial; OR; ORR = CR + PR; complete response and partial response synonym: "Confirmed response rate" [] synonym: "Disease response rate" [] synonym: "ORR" [] synonym: "Objective Rate of Response" [] synonym: "Objective response rate" [] synonym: "Objective overall response rate" [] synonym: "Objective response rates" [] synonym: "Objective tumor response rate" [] synonym: "Overall objective response rate" [] synonym: "Overall response rates" [] synonym: "Response rate" EXACT [NCIT:C94502] synonym: "Response rates" [] synonym: "Tumor response rate" [] synonym: "Tumour response rate" [] xref: UMLS:C0237629 xref: NCIT:C94502 property_value: schema "probability_t CCTO:000068(time_t t0, time_t assessed_at) = probability(CCTO:000065(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Overall response rate''(time_t t0, time_t assessed_at) = probability(''Treatment response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors [Term] id: CCTO:000069 name: Disease-free survival def: "The length of time after treatment for a specific disease during which a patient survives with no sign of recurrence of the disease." [NCIT:C17751] synonym: "DFS" [] synonym: "Disease free survival" [] xref: UMLS:C0242793 xref: NCIT:C17751 property_value: ESCORT_rule "CCTO:000069 = time-to-first CCTO:000114 CCTO:000070" xsd:string ! ESCORT_rule ''Disease-free survival'' = time-to-first ''Death'' ''Has disease'' property_value: has_operator CCTO:000011 ! has_operator is_timed_observation_of property_value: schema "duration_t CCTO:000069(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000070) )" xsd:string ! schema duration_t ''Disease-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Has disease'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000070 name: Has disease def: "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas." [NCIT:C9305] synonym: "CA" EXACT [NCIT:C9305] synonym: "Cancer" EXACT [NCIT:C9305] synonym: "Disease" [] synonym: "Malignancy" EXACT [NCIT:C9305] synonym: "Malignant growth" EXACT [NCIT:C9305] synonym: "Malignant neoplasm" EXACT [NCIT:C9305] synonym: "Malignant neoplastic disease" EXACT [NCIT:C9305] synonym: "Malignant tumor" EXACT [NCIT:C9305] synonym: "NEOPLASM, MALIGNANT" EXACT [NCIT:C9305] xref: UMLS:C0006826 xref: UMLS:C0012634 xref: UMLS:C0497565 xref: UMLS:C1306459 xref: NCIT:C9305 property_value: ESCORT_rule "CCTO:000070 globally-implies CCTO:000070" xsd:string ! ESCORT_rule ''Has disease'' globally-implies ''Has disease'' property_value: ESCORT_rule "CCTO:000070 implies CCTO:000139" xsd:string ! ESCORT_rule ''Has disease'' implies ''Invasive disease'' property_value: ESCORT_rule "CCTO:000070 implies NOT CCTO:000082" xsd:string ! ESCORT_rule ''Has disease'' implies NOT ''Complete response'' property_value: ESCORT_rule "CCTO:000070 implies NOT CCTO:000218" xsd:string ! ESCORT_rule ''Has disease'' implies NOT ''Disease-free'' property_value: ESCORT_rule "NOT CCTO:000070 implies CCTO:000218" xsd:string ! ESCORT_rule NOT ''Has disease'' implies ''Disease-free'' property_value: schema "event_t CCTO:000070(time_t t0) = EVENT_STATE(CCTO:000070, t0)" xsd:string ! schema event_t ''Has disease''(time_t t0) = EVENT_STATE(''Has disease'', t0) is_a: CCTO:000006 ! Event state disjoint_from: CCTO:000218 ! Disease-free relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000218 ! is_opposite_of Disease-free [Term] id: CCTO:000071 name: Event-free survival def: "The length of time after treatment during which a patient survives with no sign of a particular complication of disease." [NCIT:C96340] synonym: "EFS" EXACT [NCIT:C96340] synonym: "Event free survival" [] xref: UMLS:C0242793 xref: UMLS:C1424622 xref: NCIT:C96340 property_value: ESCORT_rule "CCTO:000071 = time-to-first CCTO:000114 CCTO:000137" xsd:string ! ESCORT_rule ''Event-free survival'' = time-to-first ''Death'' ''Complications'' property_value: has_operator CCTO:000011 ! has_operator is_timed_observation_of property_value: schema "duration_t CCTO:000071(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000072) )" xsd:string ! schema duration_t ''Event-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Event'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000072 name: Event def: "Something that happens at a given place and time." [NCIT:C25499] xref: UMLS:C0441471 xref: NCIT:C25499 property_value: ESCORT_rule "CCTO:000072 implies CCTO:000043" xsd:string ! ESCORT_rule ''Event'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000072(time_t t0) = EVENT_STATE(CCTO:000072, t0)" xsd:string ! schema event_t ''Event''(time_t t0) = EVENT_STATE(''Event'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000073 name: Disease control synonym: "Disease stabilization" [] synonym: "Tumor control" [] property_value: ESCORT_rule "CCTO:000073 globally-implies CCTO:000073" xsd:string ! ESCORT_rule ''Disease Control'' globally-implies ''Disease Control'' property_value: ESCORT_rule "CCTO:000073 implies CCTO:000078 " xsd:string ! ESCORT_rule ''Disease Control'' implies ''Clinical benefit'' property_value: ESCORT_rule "CCTO:000073 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Disease Control'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000073 is-union-of CCTO:000082 CCTO:000201 CCTO:000099" xsd:string ! ESCORT_rule ''Disease Control'' is-union-of ''Complete response'' ''Partial response'' ''Stable disease'' property_value: ESCORT_rule "CCTO:000082 implies CCTO:000073" xsd:string ! ESCORT_rule ''Complete response'' implies ''Disease Control'' property_value: ESCORT_rule "CCTO:000099 implies CCTO:000073" xsd:string ! ESCORT_rule ''Stable disease'' implies ''Disease Control'' property_value: ESCORT_rule "CCTO:000201 implies CCTO:000073" xsd:string ! ESCORT_rule ''Partial response'' implies ''Disease Control'' property_value: ESCORT_rule "NOT CCTO:000073 implies CCTO:000064" xsd:string ! ESCORT_rule NOT ''Disease Control'' implies ''Disease progression'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000073(time_t t0, time_t assessed_at) = CCTO:000082(t0, assessed_at) OR CCTO:000201(t0, assessed_at) OR CCTO:000099(t0, assessed_at)" xsd:string ! schema event_t ''Disease Control''(time_t t0, time_t assessed_at) = ''Complete response''(t0, assessed_at) OR ''Partial response''(t0, assessed_at) OR ''Stable disease''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy union_of: CCTO:000082 ! Complete response union_of: CCTO:000099 ! Stable disease union_of: CCTO:000201 ! Partial response disjoint_from: CCTO:000064 ! Disease progression xref: UMLS:C0920467 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000074 name: Disease control rate comment: CR+PR+SD synonym: "Tumor control rate" [] property_value: schema "probability_t CCTO:000074(time_t t0) = probability(CCTO:000073, t0)" xsd:string ! schema probability_t ''Disease Control Rate''(time_t t0) = probability(''Disease Control'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000073 ! is_probability_of Disease Control [Term] id: CCTO:000075 name: Treatment failure def: "The lack of expected or desired effect related to a therapy." [NCIT:C48226] synonym: "Efficacy lack" EXACT [NCIT:C48226] synonym: "Failure" [] synonym: "Lack of Efficacy" EXACT [NCIT:C48226] synonym: "failure of strategy" [] xref: UMLS:C0235828 xref: UMLS:C0231174 xref: UMLS:C1547544 xref: UMLS:C0680095 xref: UMLS:C0162643 xref: NCIT:C48226 property_value: ESCORT_rule "CCTO:000075 implies CCTO:000043" xsd:string ! ESCORT_rule ''Treatment failure'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000075 implies NOT CCTO:000223" xsd:string ! ESCORT_rule ''Treatment failure'' implies NOT ''On treatment'' property_value: schema "event_t CCTO:000075(time_t t0) = NOT CCTO:000223(t0)" xsd:string ! schema event_t ''Treatment failure''(time_t t0) = NOT ''On treatment''(t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000076 name: Time to treatment failure synonym: "Time to failure of strategy" [] property_value: ESCORT_rule "CCTO:000076 = time-to-first CCTO:000075" xsd:string ! ESCORT_rule ''Time to treatment failure'' = time-to-first ''Treatment failure'' property_value: schema "duration_t CCTO:000076(time_t t0) = time_to_first_event(CCTO:000075, t0)" xsd:string ! schema duration_t ''Time to treatment failure''(time_t t0) = time_to_first_event(''Treatment failure'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000077 name: Time to response synonym: "Time to First Response" [] synonym: "Time to Objective Response" [] synonym: "Time to Tumor Response" [] synonym: "Time to onset of response" [] property_value: ESCORT_rule "CCTO:000077 = time-to-first CCTO:000065" xsd:string ! ESCORT_rule ''Time to response'' = time-to-first ''Treatment response'' property_value: schema "duration_t CCTO:000077(time_t t0) = time_to_first_event(CCTO:000065, t0)" xsd:string ! schema duration_t ''Time to response''(time_t t0) = time_to_first_event(''Treatment response'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000078 name: Clinical benefit property_value: ESCORT_rule "CCTO:000078 globally-implies CCTO:000078" xsd:string ! ESCORT_rule ''Clinical benefit'' globally-implies ''Clinical benefit'' property_value: ESCORT_rule "CCTO:000078 implies CCTO:000073 " xsd:string ! ESCORT_rule ''Clinical benefit'' implies ''Disease Control'' property_value: ESCORT_rule "CCTO:000078 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Clinical benefit'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000078 is-union-of CCTO:000082 CCTO:000201 CCTO:000099" xsd:string ! ESCORT_rule ''Clinical benefit'' is-union-of ''Complete response'' ''Partial response'' ''Stable disease'' property_value: ESCORT_rule "CCTO:000082 implies CCTO:000078" xsd:string ! ESCORT_rule ''Complete response'' implies ''Clinical benefit'' property_value: ESCORT_rule "CCTO:000099 implies CCTO:000078" xsd:string ! ESCORT_rule ''Stable disease'' implies ''Clinical benefit'' property_value: ESCORT_rule "CCTO:000201 implies CCTO:000078" xsd:string ! ESCORT_rule ''Partial response'' implies ''Clinical benefit'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000078(time_t t0, time_t assessed_at) = CCTO:000082(t0, assessed_at) OR CCTO:000201(t0, assessed_at) OR CCTO:000099(t0, assessed_at)" xsd:string ! schema event_t ''Clinical benefit''(time_t t0, time_t assessed_at) = ''Complete response''(t0, assessed_at) OR ''Partial response''(t0, assessed_at) OR ''Stable disease''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy union_of: CCTO:000082 ! Complete response union_of: CCTO:000099 ! Stable disease union_of: CCTO:000201 ! Partial response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000079 name: Clinical benefit rate property_value: schema "probability_t CCTO:000079(time_t t0) = probability(CCTO:000078, t0)" xsd:string ! schema probability_t ''Clinical benefit rate''(time_t t0) = probability(''Clinical benefit'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000078 ! is_probability_of Clinical benefit [Term] id: CCTO:000080 name: Relapse-free survival synonym: "RFS" [] property_value: ESCORT_rule "CCTO:000080 = time-to-first CCTO:000114 CCTO:000081" xsd:string ! ESCORT_rule ''Relapse-free survival'' = time-to-first ''Death'' ''Relapse'' property_value: has_operator CCTO:000011 ! has_operator is_timed_observation_of property_value: schema "duration_t CCTO:000080(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000081) )" xsd:string ! schema duration_t ''Relapse-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Relapse'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy xref: UMLS:C0341703 relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000081 name: Relapse def: "The return of a disease after a period of remission." [NCIT:C38155] synonym: "DISEASE RELAPSE" EXACT [NCIT:C38155] synonym: "Recurrent disease" EXACT [NCIT:C38155] synonym: "Relapse, site not specified" EXACT [NCIT:C38155] synonym: "Relapsed disease" EXACT [NCIT:C38155] xref: UMLS:C0277556 xref: UMLS:C0035020 xref: NCIT:C18265 xref: NCIT:C38155 property_value: ESCORT_rule "CCTO:000081 implies CCTO:000064" xsd:string ! ESCORT_rule ''Relapse'' implies ''Disease progression'' property_value: ESCORT_rule "CCTO:000081 implies CCTO:000070" xsd:string ! ESCORT_rule ''Relapse'' implies ''Has disease'' property_value: schema "event_t CCTO:000081(time_t t0, time_t assessed_at) = ( CCTO:000070(t0) AND CCTO:000064(t0, assessed_at) )" xsd:string ! schema event_t ''Relapse''(time_t t0, time_t assessed_at) = ( ''Has disease''(t0) AND ''Disease progression''(t0, assessed_at) ) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000082 name: Complete response def: "The disappearance of all signs of cancer in response to treatment." [NCIT:C4870] synonym: "Cancer-free" EXACT [NCIT:C4870] synonym: "Complete remission" EXACT [NCIT:C4870] synonym: "Confirmed complete response" [] xref: UMLS:C0677874 xref: NCIT:C4870 property_value: ESCORT_rule "CCTO:000082 implies CCTO:000065" xsd:string ! ESCORT_rule ''Complete response'' implies ''Treatment response'' property_value: ESCORT_rule "CCTO:000082 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Complete response'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000082 implies NOT CCTO:000070" xsd:string ! ESCORT_rule ''Complete response'' implies NOT ''Has disease'' property_value: ESCORT_rule "CCTO:000082 implies NOT CCTO:000099" xsd:string ! ESCORT_rule ''Complete response'' implies NOT ''Stable disease'' property_value: ESCORT_rule "CCTO:000082 implies NOT CCTO:000201" xsd:string ! ESCORT_rule ''Complete response'' implies NOT ''Partial response'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: schema "event_t CCTO:000082(time_t t0) = EVENT_STATE(CCTO:000082, t0)" xsd:string ! schema event_t ''Complete response''(time_t t0) = EVENT_STATE(''Complete response'', t0) property_value: schema "event_t CCTO:000082(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000082, t0, assessed_at)" xsd:string ! schema event_t ''Complete response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Complete response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000064 ! Disease progression disjoint_from: CCTO:000099 ! Stable disease disjoint_from: CCTO:000201 ! Partial response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors [Term] id: CCTO:000083 name: Complete response rate comment: CR synonym: "CR rate" [] synonym: "Complete remission rate" [] property_value: schema "probability_t CCTO:000083(time_t t0, time_t assessed_at) = probability(CCTO:000082(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Complete response rate''(time_t t0, time_t assessed_at) = probability(''Complete response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000084 name: Health-related quality of life synonym: "Health Related Quality of Life" [] property_value: ESCORT_rule "CCTO:000084 implies CCTO:000118" xsd:string ! ESCORT_rule ''Health-related quality of life'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000084(time_t t0) = EVENT_STATE(CCTO:000084, t0)" xsd:string ! schema event_t ''Health-related quality of life''(time_t t0) = EVENT_STATE(''Health-related quality of life'', t0) is_a: CCTO:000022 ! Quality of life is_a: CCTO:000023 ! Measure of quality of life is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000263 ! is_assessed_by Expanded Prostate Cancer Index Composite [Term] id: CCTO:000085 name: Overall survival rate comment: OS synonym: "OS rate" [] synonym: "Overall survival rates" [] synonym: "Survival probability" [] synonym: "Survival rate" EXACT [NCIT:C28192] synonym: "Survival rates" [] xref: UMLS:C0038954 xref: NCIT:C28192 property_value: schema "probability_t CCTO:000085(time_t t0, time_t assessed_at) = probability(CCTO:000062(t0), assessed_at)" xsd:string ! schema probability_t ''Overall survival rate''(time_t t0, time_t assessed_at) = probability(''Overall survival''(t0), assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000011 CCTO:000062 ! is_timed_observation_of Overall survival [Term] id: CCTO:000086 name: Recurrence-free survival property_value: ESCORT_rule "CCTO:000086 = time-to-first CCTO:000114 CCTO:000087" xsd:string ! ESCORT_rule ''Recurrence-free survival'' = time-to-first ''Death'' ''Recurrence'' property_value: schema "duration_t CCTO:000086(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000087) )" xsd:string ! schema duration_t ''Recurrence-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Recurrence'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000087 name: Recurrence def: "The reemergence of a malignant neoplasm after a period of remission." [NCIT:C4813] synonym: "Disease recurrence" [] synonym: "Recurrent cancer" EXACT [NCIT:C4813] synonym: "Recurrent malignant neoplasm" EXACT [NCIT:C4813] synonym: "Recurrent malignant tumor" EXACT [NCIT:C4813] synonym: "tumor recurrence" [] xref: UMLS:C1458156 xref: UMLS:C0549379 xref: UMLS:C2825055 xref: UMLS:C0679254 xref: UMLS:C0521158 xref: NCIT:C4813 property_value: ESCORT_rule "CCTO:000087 implies CCTO:000064" xsd:string ! ESCORT_rule ''Recurrence'' implies ''Disease progression'' property_value: ESCORT_rule "CCTO:000087 implies CCTO:000070" xsd:string ! ESCORT_rule ''Recurrence'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000087 implies NOT CCTO:000168" xsd:string ! ESCORT_rule ''Recurrence'' implies NOT ''Recurrence-free'' property_value: ESCORT_rule "NOT CCTO:000087 implies CCTO:000168" xsd:string ! ESCORT_rule NOT ''Recurrence'' implies ''Recurrence-free'' property_value: schema "event_t CCTO:000087(time_t t0, time_t assessed_at) = ( NOT CCTO:000070(t0) AND CCTO:000070(assessed_at) )" xsd:string ! schema event_t ''Recurrence''(time_t t0, time_t assessed_at) = ( NOT ''Has disease''(t0) AND ''Has disease''(assessed_at) ) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000168 ! Recurrence-free relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000168 ! is_opposite_of Recurrence-free [Term] id: CCTO:000088 name: Pathologic complete response def: "The disappearance of all signs of cancer, supported by pathological examination." [NCIT:C123603] synonym: "Complete pathological response" EXACT [NCIT:C123603] synonym: "Pathologic complete remission" EXACT [NCIT:C123603] synonym: "Pathological complete remission" EXACT [NCIT:C123603] synonym: "Pathological complete response" [] synonym: "pCR" EXACT [NCIT:C123603] xref: UMLS:C0677874 xref: UMLS:C0032520 xref: NCIT:C123603 property_value: schema "event_t CCTO:000088(time_t t0) = EVENT_STATE(CCTO:000088, t0)" xsd:string ! schema event_t ''Pathologic complete response''(time_t t0) = EVENT_STATE(''Pathologic complete response'', t0) property_value: schema "event_t CCTO:000088(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000088, t0, assessed_at)" xsd:string ! schema event_t ''Pathologic complete response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Pathologic complete response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000089 name: Best overall response def: "The most clinically favorable response recorded from the start of the study treatment until the end of treatment." [NCIT:C94536] synonym: "BESTRESP" EXACT [NCIT:C94536] synonym: "Best objective response" [] synonym: "Best overall tumor response" [] synonym: "Best response" EXACT [NCIT:C94536] synonym: "Best tumor response" [] synonym: "Overall best response" [] xref: UMLS:C2986560 xref: NCIT:C94536 property_value: schema "event_t CCTO:000089(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000089, t0, assessed_at)" xsd:string ! schema event_t ''Best overall response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Best overall response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors [Term] id: CCTO:000090 name: Treatment-related mortality property_value: ESCORT_rule "CCTO:000090 implies CCTO:000098" xsd:string ! ESCORT_rule ''Treatment-related mortality'' implies ''Treatment-related adverse events '' property_value: ESCORT_rule "CCTO:000090 implies CCTO:000114" xsd:string ! ESCORT_rule ''Treatment-related mortality'' implies ''Death'' property_value: schema "event_t CCTO:000090(time_t t0) = CCTO:000114(t0) AND ASSOCIATED(CCTO:000114, CCTO:000223)" xsd:string ! schema event_t ''Treatment-related mortality''(time_t t0) = ''Death''(t0) AND ASSOCIATED(''Death'', ''On treatment'') is_a: CCTO:000114 ! Death relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000091 name: Progression-free survival rate synonym: "PFS rate" [] synonym: "Progression free survival rate" [] synonym: "Progression free survival rates" [] property_value: schema "probability_t CCTO:000091(time_t t0, time_t assessed_at) = probability(CCTO:000063(t0), assessed_at)" xsd:string ! schema probability_t ''Progression-free survival rate''(time_t t0, time_t assessed_at) = probability(''Progression-free survival''(t0), assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000011 CCTO:000063 ! is_timed_observation_of Progression-free survival [Term] id: CCTO:000092 name: Clinical response def: "An evaluation of the clinical response of the disease to the therapy." [NCIT:C123619] synonym: "CLINRESP" EXACT [NCIT:C123619] xref: NCIT:C123619 property_value: ESCORT_rule "CCTO:000092 implies NOT CCTO:000175" xsd:string ! ESCORT_rule ''Clinical response'' implies NOT ''Clinical progression'' property_value: schema "event_t CCTO:000092(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000092, t0, assessed_at)" xsd:string ! schema event_t ''Clinical response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Clinical response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000175 ! Clinical progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000093 name: Clinical response rate synonym: "Clinical response rates" [] property_value: schema "probability_t CCTO:000093(time_t t0, time_t assessed_at) = probability(CCTO:000092(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Clinical response rate''(time_t t0, time_t assessed_at) = probability(''Clinical response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000094 name: Failure-free survival property_value: ESCORT_rule "CCTO:000094 = time-to-first CCTO:000114 CCTO:000075" xsd:string ! ESCORT_rule ''Failure-free survival'' = time-to-first ''Death'' ''Treatment failure'' property_value: schema "duration_t CCTO:000094(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000075) )" xsd:string ! schema duration_t ''Failure-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Treatment failure'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000095 name: Best overall response rate synonym: "Best response rate" [] synonym: "best objective response rate" [] property_value: schema "probability_t CCTO:000095(time_t t0, time_t assessed_at) = probability(CCTO:000089(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Best overall response rate''(time_t t0, time_t assessed_at) = probability(''Best overall response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000096 name: Mortality def: "The ratio of deaths in an area to the population of that area, expressed as deaths per 1000 per year." [NCIT:C16880] synonym: "All-cause mortality" [] synonym: "Overall mortality" [] xref: UMLS:C0026565 xref: NCIT:C16880 property_value: ESCORT_rule "CCTO:000096 implies CCTO:000043" xsd:string ! ESCORT_rule ''Mortality'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000096 implies CCTO:000114" xsd:string ! ESCORT_rule ''Mortality'' implies ''Death'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000096(time_t t0) = CCTO:000114(t0)" xsd:string ! schema event_t ''Mortality''(time_t t0) = ''Death''(t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000097 name: Time to recurrence synonym: "Recurrence-free interval" [] property_value: ESCORT_rule "CCTO:000097 = time-to-first CCTO:000114 CCTO:000087" xsd:string ! ESCORT_rule ''Time to recurrence'' = time-to-first ''Death'' ''Recurrence'' property_value: schema "duration_t CCTO:000097(time_t t0) = time_to_first_event(CCTO:000087, t0)" xsd:string ! schema duration_t ''Time to recurrence''(time_t t0) = time_to_first_event(''Recurrence'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000098 name: Treatment-related adverse events comment: Safety and Tolerability synonym: "Treatment emergent adverse events" [] synonym: "Treatment related adverse events" [] synonym: "Treatment related morbidity" [] synonym: "Treatment-emergent adverse events" [] synonym: "Treatment-related adverse events" [] property_value: ESCORT_rule "CCTO:000098 implies CCTO:000049" xsd:string ! ESCORT_rule ''Treatment-related adverse events '' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000098 implies CCTO:000137" xsd:string ! ESCORT_rule ''Treatment-related adverse events '' implies ''Complications'' property_value: schema "unknown_t CCTO:000098(time_t t0) = EVENT_STATE(CCTO:000098, t0)" xsd:string ! schema unknown_t ''Treatment-related adverse events ''(time_t t0) = EVENT_STATE(''Treatment-related adverse events '', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000137 ! Complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000099 name: Stable disease def: "Cancer that is neither decreasing nor increasing in extent or severity." [NCIT:C18213] xref: UMLS:C0677946 xref: UMLS:C3538874 xref: NCIT:C18213 property_value: ESCORT_rule "CCTO:000099 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Stable disease'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000099 implies NOT CCTO:000065" xsd:string ! ESCORT_rule ''Stable disease'' implies NOT ''Treatment response'' property_value: ESCORT_rule "CCTO:000099 implies NOT CCTO:000082" xsd:string ! ESCORT_rule ''Stable disease'' implies NOT ''Complete response'' property_value: ESCORT_rule "CCTO:000099 implies NOT CCTO:000201" xsd:string ! ESCORT_rule ''Stable disease'' implies NOT ''Partial response'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000099(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000099, t0, assessed_at)" xsd:string ! schema event_t ''Stable disease''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Stable disease'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000064 ! Disease progression disjoint_from: CCTO:000065 ! Treatment response disjoint_from: CCTO:000082 ! Complete response disjoint_from: CCTO:000201 ! Partial response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors [Term] id: CCTO:000100 name: Duration of stable disease property_value: schema "duration_t CCTO:000100(time_t t0) = duration_of_event(CCTO:000099, t0)" xsd:string ! schema duration_t ''Duration of stable disease''(time_t t0) = duration_of_event(''Stable disease'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000099 ! is_duration_of Stable disease [Term] id: CCTO:000101 name: R0 resection synonym: "curative resection" [] property_value: ESCORT_rule "CCTO:000101 implies CCTO:000163" xsd:string ! ESCORT_rule ''R0 resection'' implies ''Resection'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000101(time_t t0) = EVENT_STATE(CCTO:000101, t0)" xsd:string ! schema event_t ''R0 resection''(time_t t0) = EVENT_STATE(''R0 resection'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000102 name: R0 resection rate synonym: "curative resection rate" [] property_value: schema "probability_t CCTO:000102(time_t t0) = probability(CCTO:000101, t0)" xsd:string ! schema probability_t ''R0 resection rate''(time_t t0) = probability(''R0 resection'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000101 ! is_probability_of R0 resection [Term] id: CCTO:000103 name: PSA progression def: "The amount of prostate specific antigen is increased, based on pre-defined thresholds." [NCIT:C123611] xref: NCIT:C123611 property_value: ESCORT_rule "CCTO:000103 implies CCTO:001107" xsd:string ! ESCORT_rule ''PSA progression'' implies ''Tumor marker increased'' property_value: ESCORT_rule "CCTO:000103 implies NOT CCTO:000120" xsd:string ! ESCORT_rule ''PSA progression'' implies NOT ''PSA response'' property_value: ESCORT_rule "CCTO:000103 implies NOT CCTO:000295" xsd:string ! ESCORT_rule ''PSA progression'' implies NOT ''Biochemical control'' property_value: schema "event_t CCTO:000103(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000103, t0, assessed_at)" xsd:string ! schema event_t ''PSA progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''PSA progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000120 ! PSA response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000104 name: Time to PSA progression property_value: ESCORT_rule "CCTO:000104 = time-to-first CCTO:000103 " xsd:string ! ESCORT_rule ''Time to PSA progression'' = time-to-first ''PSA progression'' property_value: schema "duration_t CCTO:000104(time_t t0) = time_to_first_event(CCTO:000103, t0)" xsd:string ! schema duration_t ''Time to PSA progression''(time_t t0) = time_to_first_event(''PSA progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000105 name: Disease-specific survival synonym: "Cancer-specific survival" [] synonym: "Cause specific survival" EXACT [NCIT:C53371] synonym: "Specific survival" [] xref: UMLS:C1707318 xref: NCIT:C53371 property_value: ESCORT_rule "CCTO:000105 = time-to-first CCTO:001102" xsd:string ! ESCORT_rule ''Disease-specific survival'' = time-to-first ''Disease-specific death'' property_value: schema "duration_t CCTO:000105(time_t t0) = EVENT_STATE(CCTO:001102, t0) ? CCTO:000062(t0) : NULL" xsd:string ! schema duration_t ''Disease-specific survival''(time_t t0) = EVENT_STATE(''Disease-specific death'', t0) ? ''Overall survival''(t0) : NULL is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000106 name: Local control synonym: "Local tumor control" [] property_value: ESCORT_rule "CCTO:000106 implies NOT CCTO:000147" xsd:string ! ESCORT_rule ''Local control'' implies NOT ''Local progression'' property_value: ESCORT_rule "CCTO:000106 implies NOT CCTO:000153" xsd:string ! ESCORT_rule ''Local control'' implies NOT ''Local recurrence'' property_value: ESCORT_rule "CCTO:000106 implies NOT CCTO:000244" xsd:string ! ESCORT_rule ''Local control'' implies NOT ''Local relapse'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000106(time_t t0) = EVENT_STATE(CCTO:000106, t0)" xsd:string ! schema event_t ''Local control''(time_t t0) = EVENT_STATE(''Local control'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000147 ! Local progression disjoint_from: CCTO:000244 ! Local relapse relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000107 name: Pain def: "The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings OR A disorder characterized by the sensation of marked discomfort, distress or agony." [NCIT:C3303, NCI:CTCAE] xref: UMLS:C0030193 xref: UMLS:C2598155 xref: NCI:CTCAE:10033371 xref: NCIT:C3303 property_value: ESCORT_rule "CCTO:000107 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pain'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000107 implies CCTO:001103" xsd:string ! ESCORT_rule ''Pain'' implies ''General disorders and administration site conditions'' is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000157 ! is_assessed_by Pain score relationship: CCTO:000009 CCTO:000230 ! is_assessed_by Brief Pain Inventory relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000108 name: Immune response def: "Any immune system response of an organisms to an internal or invasive threat." [NCIT:C17930] synonym: "Immune response process" EXACT [NCIT:C17930] synonym: "Immunological response" [] xref: UMLS:C0301872 xref: NCIT:C17930 property_value: schema "event_t CCTO:000108(time_t t0) = EVENT_STATE(CCTO:000108, t0)" xsd:string ! schema event_t ''Immune response''(time_t t0) = EVENT_STATE(''Immune response'', t0) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000109 name: Recurrence rate synonym: "Recurrence rates" [] property_value: schema "probability_t CCTO:000109(time_t t0, time_t assessed_at) = probability(CCTO:000087(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Recurrence rate''(time_t t0, time_t assessed_at) = probability(''Recurrence''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000110 name: Side effects def: "The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction." [NCIT:C2861] synonym: "Side effect" EXACT [NCIT:C2861] xref: UMLS:C0879626 xref: UMLS:C0001688 xref: NCIT:C2861 property_value: ESCORT_rule "CCTO:000110 implies CCTO:000049" xsd:string ! ESCORT_rule ''Side effects'' implies ''Adverse events'' property_value: schema "event_t CCTO:000110(time_t t0) = EVENT_STATE(CCTO:000110, t0)" xsd:string ! schema event_t ''Side effects''(time_t t0) = EVENT_STATE(''Side effects'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000111 name: Radiographic progression-free survival synonym: "Radiologic progression free survival" [] synonym: "Radiological progression free survival" [] property_value: ESCORT_rule "CCTO:000111 = time-to-first CCTO:000114 CCTO:000112 " xsd:string ! ESCORT_rule ''Radiographic progression-free survival'' = time-to-first ''Death'' ''Radiographic progression'' property_value: schema "duration_t CCTO:000111(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000112) )" xsd:string ! schema duration_t ''Radiographic progression-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Radiographic progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000112 name: Radiographic progression property_value: ESCORT_rule "CCTO:000112 implies NOT CCTO:000159" xsd:string ! ESCORT_rule ''Radiographic progression'' implies NOT ''Radiographic response'' property_value: schema "event_t CCTO:000112(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000112, t0, assessed_at)" xsd:string ! schema event_t ''Radiographic progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Radiographic progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000159 ! Radiographic response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000113 name: Length of hospital stay synonym: "Duration of hospital stay" [] synonym: "Duration of hospitalization" [] synonym: "Hospital length of stay" [] synonym: "Hospitalization time" [] synonym: "Length of stay" [] property_value: ESCORT_rule "CCTO:000113 = measured-from-first CCTO:000150 time-to-last CCTO:000150" xsd:string ! ESCORT_rule ''Length of hospital stay'' = measured-from-first ''Hospital stay'' time-to-last ''Hospital stay'' property_value: schema "duration_t CCTO:000113(time_t t0) = duration_of_event(CCTO:000150, t0)" xsd:string ! schema duration_t ''Length of hospital stay''(time_t t0) = duration_of_event(''Hospital stay'', t0) is_a: CCTO:000003 ! Duration is_a: CCTO:000003 ! duration is_a: CCTO:000035 ! Measure of healthcare resource utilization xref: UMLS:C0023303 relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000150 ! is_duration_of Hospital stay [Term] id: CCTO:000114 name: Death def: "The cessation of life OR A cessation of life that cannot be attributed to a CTCAE term associated with Grade 5." [NCIT:C28554, NCI:CTCAE] synonym: "Dead" EXACT [NCIT:C28554] synonym: "Death Adverse Event Not Associated with More Specific CTCAE Term NOS" EXACT [NCIT:C55284] synonym: "Death NOS" EXACT [NCIT:C28554] synonym: "Death NOS" EXACT [NCIT:C55284] synonym: "Deceased" EXACT [NCIT:C28554] synonym: "Died" EXACT [NCIT:C28554] synonym: "EXPIRED" EXACT [NCIT:C28554] synonym: "Expired/death" EXACT [NCIT:C28554] xref: UMLS:C0011065 xref: UMLS:C1549464 xref: UMLS:C1546949 xref: UMLS:C1306577 xref: UMLS:C1549070 xref: NCI:CTCAE:10011914 xref: NCIT:C28554 xref: NCIT:C55284 property_value: ESCORT_rule "CCTO:000114 globally-implies CCTO:000114 " xsd:string ! ESCORT_rule ''Death'' globally-implies ''Death'' property_value: ESCORT_rule "CCTO:000114 implies CCTO:000049" xsd:string ! ESCORT_rule ''Death'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000114 implies CCTO:001103" xsd:string ! ESCORT_rule ''Death'' implies ''General disorders and administration site conditions'' property_value: is_irreversible true xsd:boolean ! is_irreversible property_value: schema "CCTO:000114(time_t t0) = EVENT_STATE(CCTO:000114, t0)" xsd:string ! schema ''Death''(time_t t0) = EVENT_STATE(''Death'', t0) property_value: schema "event_t CCTO:000114(time_t t0) = EVENT_STATE(CCTO:000114, t0)" xsd:string ! schema event_t ''Death''(time_t t0) = EVENT_STATE(''Death'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000115 name: Metastasis-free survival synonym: "Metastases-free survival" [] property_value: ESCORT_rule "CCTO:000115 = time-to-first CCTO:000114 CCTO:000058 " xsd:string ! ESCORT_rule ''Metastasis-free survival'' = time-to-first ''Death'' ''Has metastasis'' property_value: schema "duration_t CCTO:000115(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000058) )" xsd:string ! schema duration_t ''Metastasis-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Has metastasis'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000116 name: Next treatment synonym: "Next therapy" [] property_value: ESCORT_rule "CCTO:000116 implies CCTO:000043" xsd:string ! ESCORT_rule ''Next treatment'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000116(time_t t0) = EVENT_STATE(CCTO:000116, t0)" xsd:string ! schema event_t ''Next treatment''(time_t t0) = EVENT_STATE(''Next treatment'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000117 name: Time to next treatment synonym: "Time to Next Therapy" [] property_value: ESCORT_rule "CCTO:000117 = time-to-first CCTO:000116" xsd:string ! ESCORT_rule ''Time to next treatment'' = time-to-first ''Next treatment'' property_value: schema "duration_t CCTO:000117(time_t t0) = time_to_first_event(CCTO:000116, t0)" xsd:string ! schema duration_t ''Time to next treatment''(time_t t0) = time_to_first_event(''Next treatment'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000118 name: Patient reported outcomes def: "Information collected directly from a patient that typically includes subjective feelings regarding symptoms, functions in daily life, physical, mental, emotional, spiritual, and social well being, and satisfaction with his/her health care." [NCIT:C95401] synonym: "PRO" EXACT [NCIT:C95401] synonym: "Patient reported outcome" EXACT [NCIT:C95401] xref: UMLS:C2987124 xref: UMLS:C0033382 xref: NCIT:C95401 property_value: schema "event_t CCTO:000118(time_t t0) = EVENT_STATE(CCTO:000118, t0)" xsd:string ! schema event_t ''Patient reported outcomes''(time_t t0) = EVENT_STATE(''Patient reported outcomes'', t0) is_a: CCTO:000050 ! Assessment tool relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000119 name: Local control rate property_value: schema "probability_t CCTO:000119(time_t t0) = probability(CCTO:000106, t0)" xsd:string ! schema probability_t ''Local control rate''(time_t t0) = probability(''Local control'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000106 ! is_probability_of Local control [Term] id: CCTO:000120 name: PSA response property_value: ESCORT_rule "CCTO:000120 implies CCTO:000295" xsd:string ! ESCORT_rule ''PSA response'' implies ''Biochemical control'' property_value: ESCORT_rule "CCTO:000120 implies NOT CCTO:000103" xsd:string ! ESCORT_rule ''PSA response'' implies NOT ''PSA progression'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000120(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000120, t0, assessed_at)" xsd:string ! schema event_t ''PSA response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''PSA response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000103 ! PSA progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000121 name: Acute toxicity property_value: schema "event_t CCTO:000121(time_t t0) = EVENT_STATE(CCTO:000121, t0)" xsd:string ! schema event_t ''Acute toxicity''(time_t t0) = EVENT_STATE(''Acute toxicity'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000122 name: Distant disease-free survival synonym: "Distant metastases free survival" [] synonym: "Distant metastasis-free survival" [] property_value: ESCORT_rule "CCTO:000122 = time-to-first CCTO:000114 CCTO:000058" xsd:string ! ESCORT_rule ''Distant disease-free survival'' = time-to-first ''Death'' ''Has metastasis'' property_value: schema "duration_t CCTO:000122(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000058) )" xsd:string ! schema duration_t ''Distant disease-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Has metastasis'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000123 name: Morbidity def: "Morbidity; the relative incidence of a particular disease in a population." [NCIT:C16877] xref: UMLS:C0026538 xref: NCIT:C16877 property_value: schema "type_t CCTO:000123(time_t t0) = EVENT_STATE(CCTO:000123, t0)" xsd:string ! schema type_t ''Morbidity''(time_t t0) = EVENT_STATE(''Morbidity'', t0) is_a: CCTO:000036 ! Performance Status is_a: CCTO:000037 ! Measure of performance status relationship: CCTO:000009 CCTO:000018 ! is_assessed_by Neurocognitive function [Term] id: CCTO:000124 name: Postoperative complications synonym: "Post-operative complications" [] synonym: "Postoperative complication" [] property_value: ESCORT_rule "CCTO:000124 implies CCTO:000098" xsd:string ! ESCORT_rule ''Postoperative complications'' implies ''Treatment-related adverse events '' property_value: schema "event_t CCTO:000124(time_t t0) = EVENT_STATE(CCTO:000124, t0)" xsd:string ! schema event_t ''Postoperative complications''(time_t t0) = EVENT_STATE(''Postoperative complications'', t0) is_a: CCTO:000098 ! Treatment-related adverse events xref: UMLS:C0032787 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000125 name: Duration of disease control property_value: schema "duration_t CCTO:000125(time_t t0) = duration_of_event(CCTO:000073, t0)" xsd:string ! schema duration_t ''Duration of disease control''(time_t t0) = duration_of_event(''Disease Control'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000073 ! is_duration_of Disease Control [Term] id: CCTO:000126 name: Relapse rate synonym: "Relapse rates" [] property_value: schema "probability_t CCTO:000126(time_t t0, time_t assessed_at) = probability(CCTO:000081(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Relapse rate''(time_t t0, time_t assessed_at) = probability(''Relapse''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000127 name: Pathologic complete response rate synonym: "Complete pathological response rate" [] synonym: "Pathological complete response rate" [] synonym: "pCR rate" [] property_value: schema "probability_t CCTO:000127(time_t t0, time_t assessed_at) = probability(CCTO:000088(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Pathologic complete response rate''(time_t t0, time_t assessed_at) = probability(''Pathologic complete response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000128 name: Fatigue def: "Overall tiredness and lack of energy OR A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities." [NCIT:C3036, NCI:CTCAE] synonym: "Lack of Energy" EXACT [NCIT:C3036] xref: UMLS:C0015672 xref: NCI:CTCAE:10016256 xref: NCIT:C3036 property_value: ESCORT_rule "CCTO:000128 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fatigue'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000128 implies CCTO:001103" xsd:string ! ESCORT_rule ''Fatigue'' implies ''General disorders and administration site conditions'' is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000307 ! is_assessed_by Brief Fatigue Inventory relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000129 name: Infections def: "A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact." [NCIT:C26726] synonym: "Infection" EXACT [NCIT:C26726] synonym: "Infectious disease" EXACT [NCIT:C26726] synonym: "Infectious Diseases and Manifestations" EXACT [NCIT:C26726] synonym: "Infectious disorder" EXACT [NCIT:C26726] synonym: "Infectious" EXACT [NCIT:C26726] xref: UMLS:C0009450 xref: UMLS:C3714514 xref: UMLS:C3714515 xref: UMLS:C1550587 xref: NCIT:C26726 property_value: ESCORT_rule "CCTO:000129 implies CCTO:000043" xsd:string ! ESCORT_rule ''Infections'' implies ''Measure of safety'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000129(time_t t0) = EVENT_STATE(CCTO:000129, t0)" xsd:string ! schema event_t ''Infections''(time_t t0) = EVENT_STATE(''Infections'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000130 name: Pain progression property_value: ESCORT_rule "CCTO:000130 implies CCTO:000043" xsd:string ! ESCORT_rule ''Pain progression'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000130 implies CCTO:000107" xsd:string ! ESCORT_rule ''Pain progression'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000130 implies NOT CCTO:000178" xsd:string ! ESCORT_rule ''Pain progression'' implies NOT ''Pain response'' property_value: ESCORT_rule "CCTO:000130 implies NOT CCTO:000257" xsd:string ! ESCORT_rule ''Pain progression'' implies NOT ''Pain relief'' property_value: ESCORT_rule "CCTO:000130 implies NOT CCTO:000340" xsd:string ! ESCORT_rule ''Pain progression'' implies NOT ''Pain control'' property_value: schema "event_t CCTO:000130(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000130, t0, assessed_at)" xsd:string ! schema event_t ''Pain progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Pain progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety disjoint_from: CCTO:000178 ! Pain response disjoint_from: CCTO:000257 ! Pain relief disjoint_from: CCTO:000340 ! Pain control relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000131 name: Time to pain progression property_value: ESCORT_rule "CCTO:000131 = time-to-first CCTO:000130" xsd:string ! ESCORT_rule ''Time to pain progression'' = time-to-first ''Pain progression'' property_value: schema "duration_t CCTO:000131(time_t t0) = time_to_first_event(CCTO:000130, t0)" xsd:string ! schema duration_t ''Time to pain progression''(time_t t0) = time_to_first_event(''Pain progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000132 name: PSA response rate property_value: schema "probability_t CCTO:000132(time_t t0) = probability(CCTO:000120, t0)" xsd:string ! schema probability_t ''PSA response rate''(time_t t0) = probability(''PSA response'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000120 ! is_probability_of PSA response [Term] id: CCTO:000133 name: Clinical benefit response synonym: "Symptomatic benefit" [] property_value: schema "event_t CCTO:000133(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000133, t0, assessed_at)" xsd:string ! schema event_t ''Clinical benefit response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Clinical benefit response'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000134 name: Remission def: "An abatement in intensity or degree (as in the manifestations of a disease)." [NCIT:C18246] synonym: "Overall remission" [] xref: UMLS:C0687702 xref: UMLS:C0544452 xref: NCIT:C18246 property_value: ESCORT_rule "CCTO:000082 implies CCTO:000134" xsd:string ! ESCORT_rule ''Complete response'' implies ''Remission'' property_value: ESCORT_rule "CCTO:000134 is-union-of CCTO:000082 CCTO:000201" xsd:string ! ESCORT_rule ''Remission'' is-union-of ''Complete response'' ''Partial response'' property_value: ESCORT_rule "CCTO:000201 implies CCTO:000134" xsd:string ! ESCORT_rule ''Partial response'' implies ''Remission'' property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000134(time_t t0) = EVENT_STATE(CCTO:000134, t0)" xsd:string ! schema event_t ''Remission''(time_t t0) = EVENT_STATE(''Remission'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy union_of: CCTO:000082 ! Complete response union_of: CCTO:000201 ! Partial response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000135 name: Duration of remission synonym: "Remission duration" [] property_value: ESCORT_rule "CCTO:000135 = measured-from CCTO:000054 CCTO:000067" xsd:string ! ESCORT_rule ''Duration of remission'' = measured-from ''Treatment start'' ''Time to progression'' property_value: schema "duration_t CCTO:000135(time_t t0) = duration_of_event(CCTO:000134, t0)" xsd:string ! schema duration_t ''Duration of remission''(time_t t0) = duration_of_event(''Remission'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000134 ! is_duration_of Remission [Term] id: CCTO:000136 name: Late toxicity synonym: "late toxicities" [] property_value: schema "event_t CCTO:000136(time_t t0) = EVENT_STATE(CCTO:000136, t0)" xsd:string ! schema event_t ''Late toxicity''(time_t t0) = EVENT_STATE(''Late toxicity'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000137 name: Complications def: "Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure." [NCIT:C2959] synonym: "Complication" EXACT [NCIT:C2959] xref: UMLS:C0009566 xref: UMLS:C0802632 xref: NCIT:C2959 property_value: ESCORT_rule "CCTO:000137 implies CCTO:001120" xsd:string ! ESCORT_rule ''Complications'' implies ''Injury, poisoning and procedural complications'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000137(time_t t0) = EVENT_STATE(CCTO:000137, t0)" xsd:string ! schema event_t ''Complications''(time_t t0) = EVENT_STATE(''Complications'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000138 name: Invasive disease-free survival property_value: ESCORT_rule "CCTO:000138 = time-to-first CCTO:000114 CCTO:000139" xsd:string ! ESCORT_rule ''Invasive disease-free survival'' = time-to-first ''Death'' ''Invasive disease'' property_value: schema "duration_t CCTO:000138(time_t t0) = min( time_to_first_event(t0, CCTO:000291), time_to_first_event(t0, CCTO:000087), time_to_first_event(t0, CCTO:000153), time_to_first_event(t0, CCTO:001104), time_to_first_event(t0, CCTO:000215), time_to_first_event(t0, CCTO:000114) )" xsd:string ! schema duration_t ''Invasive disease-free survival''(time_t t0) = min( time_to_first_event(t0, ''Breast cancer''), time_to_first_event(t0, ''Recurrence''), time_to_first_event(t0, ''Local recurrence''), time_to_first_event(t0, ''Regional recurrence''), time_to_first_event(t0, ''Distant recurrence''), time_to_first_event(t0, ''Death'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000139 name: Invasive disease property_value: ESCORT_rule "CCTO:000087 implies CCTO:000139" xsd:string ! ESCORT_rule ''Recurrence'' implies ''Invasive disease'' property_value: ESCORT_rule "CCTO:000139 implies CCTO:000070" xsd:string ! ESCORT_rule ''Invasive disease'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000139 is-union-of CCTO:000087 CCTO:000153 CCTO:001104 CCTO:000215" xsd:string ! ESCORT_rule ''Invasive disease'' is-union-of ''Recurrence'' ''Local recurrence'' ''Regional recurrence'' ''Distant recurrence'' property_value: ESCORT_rule "CCTO:000153 implies CCTO:000139" xsd:string ! ESCORT_rule ''Local recurrence'' implies ''Invasive disease'' property_value: ESCORT_rule "CCTO:000215 implies CCTO:000139" xsd:string ! ESCORT_rule ''Distant recurrence'' implies ''Invasive disease'' property_value: ESCORT_rule "CCTO:001104 implies CCTO:000139" xsd:string ! ESCORT_rule ''Regional recurrence'' implies ''Invasive disease'' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state union_of: CCTO:000087 ! Recurrence union_of: CCTO:000153 ! Local recurrence union_of: CCTO:000215 ! Distant recurrence union_of: CCTO:001104 ! Regional recurrence relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000140 name: Time to relapse property_value: ESCORT_rule "CCTO:000140 = time-to-first CCTO:000081" xsd:string ! ESCORT_rule ''Time to relapse'' = time-to-first ''Relapse'' property_value: schema "duration_t CCTO:000140(time_t t0) = time_to_first_event(CCTO:000081, t0)" xsd:string ! schema duration_t ''Time to relapse''(time_t t0) = time_to_first_event(''Relapse'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000141 name: Body Mass Index def: "A general indicator of the body fat an individual is carrying based upon the ratio of weight to height." [NCIT:C16358] synonym: "BMI" EXACT [NCIT:C16358] synonym: "Quetelet Index" EXACT [NCIT:C16358] xref: UMLS:C0005893 xref: UMLS:C1305855 xref: UMLS:C2240399 xref: UMLS:C1542867 xref: NCIT:C16358 property_value: ESCORT_rule "CCTO:000141 implies CCTO:000043" xsd:string ! ESCORT_rule ''Body Mass Index'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000141(time_t t0) = EVENT_STATE(CCTO:000141, t0)" xsd:string ! schema event_t ''Body Mass Index''(time_t t0) = EVENT_STATE(''Body Mass Index'', t0) is_a: CCTO:000033 ! Measure of nutritional status is_a: CCTO:000043 ! Measure of safety is_a: CCTO:001132 ! Anthropometry relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000142 name: Bone mineral density def: "A scanning procedure used to measure calcium and other minerals present in bone." [NCIT:C61545] synonym: "BMD" EXACT [NCIT:C61545] synonym: "Bone density test" EXACT [NCIT:C61545] synonym: "Bone mineral density test" EXACT [NCIT:C61545] synonym: "bone density" EXACT [NCIT:C61545] synonym: "bone mass" EXACT [NCIT:C61545] xref: UMLS:C0005938 xref: UMLS:C0177804 xref: NCIT:C61545 property_value: ESCORT_rule "CCTO:000142 implies CCTO:000043" xsd:string ! ESCORT_rule ''Bone mineral density'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000142 implies CCTO:000051" xsd:string ! ESCORT_rule ''Bone mineral density'' implies ''Investigation'' property_value: schema "unknown_t CCTO:000142(time_t t0) = EVENT_STATE(CCTO:000142, t0)" xsd:string ! schema unknown_t ''Bone mineral density''(time_t t0) = EVENT_STATE(''Bone mineral density'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000051 ! Investigation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000143 name: Disease free survival rate property_value: schema "probability_t CCTO:000143(time_t t0, time_t assessed_at) = probability(CCTO:000069(t0), assessed_at)" xsd:string ! schema probability_t ''Disease free survival rate''(time_t t0, time_t assessed_at) = probability(''Disease-free survival''(t0), assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000011 CCTO:000069 ! is_timed_observation_of Disease-free survival [Term] id: CCTO:000144 name: Progression-free synonym: "Freedom from progression" [] property_value: ESCORT_rule "CCTO:000144 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Progression-free'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000144 implies NOT CCTO:000147" xsd:string ! ESCORT_rule ''Progression-free'' implies NOT ''Local progression'' property_value: ESCORT_rule "NOT CCTO:000144 implies CCTO:000064" xsd:string ! ESCORT_rule NOT ''Progression-free'' implies ''Disease progression'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000144(time_t t0, time_t assessed_at) = NOT CCTO:000064(t0, assessed_at)" xsd:string ! schema event_t ''Progression-free''(time_t t0, time_t assessed_at) = NOT ''Disease progression''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000064 ! Disease progression disjoint_from: CCTO:000147 ! Local progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000064 ! is_opposite_of Disease progression [Term] id: CCTO:000145 name: Treatment related toxicity synonym: "Treatment related toxicities" [] property_value: ESCORT_rule "CCTO:000145 implies CCTO:000048" xsd:string ! ESCORT_rule ''Treatment related toxicity'' implies ''Toxicity'' property_value: ESCORT_rule "CCTO:000145 implies CCTO:000049" xsd:string ! ESCORT_rule ''Treatment related toxicity'' implies ''Adverse events'' property_value: schema "event_t CCTO:000145(time_t t0) = EVENT_STATE(CCTO:000145, t0)" xsd:string ! schema event_t ''Treatment related toxicity''(time_t t0) = EVENT_STATE(''Treatment related toxicity'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000146 name: Local progression-free survival property_value: schema "duration_t CCTO:000146(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000147) )" xsd:string ! schema duration_t ''Local progression-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Local progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000147 name: Local progression property_value: ESCORT_rule "CCTO:000147 implies CCTO:000056" xsd:string ! ESCORT_rule ''Local progression'' implies ''Has local disease'' property_value: ESCORT_rule "CCTO:000147 implies CCTO:000064" xsd:string ! ESCORT_rule ''Local progression'' implies ''Disease progression'' property_value: ESCORT_rule "CCTO:000147 implies NOT CCTO:000106" xsd:string ! ESCORT_rule ''Local progression'' implies NOT ''Local control'' property_value: ESCORT_rule "CCTO:000147 implies NOT CCTO:000144" xsd:string ! ESCORT_rule ''Local progression'' implies NOT ''Progression-free'' property_value: schema "event_t CCTO:000147(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000147, t0, assessed_at)" xsd:string ! schema event_t ''Local progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Local progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000106 ! Local control disjoint_from: CCTO:000144 ! Progression-free relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000148 name: Pathological response def: "An evaluation of the pathologic response of the disease to the therapy." [NCIT:C123626] synonym: "PATHRESP" EXACT [NCIT:C123626] synonym: "Pathologic response" EXACT [NCIT:C123626] xref: NCIT:C123626 property_value: schema "event_t CCTO:000148(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000148, t0, assessed_at)" xsd:string ! schema event_t ''Pathological response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Pathological response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000149 name: Pathological response rate synonym: "Pathologic response rate" [] property_value: schema "probability_t CCTO:000149(time_t t0, time_t assessed_at) = probability(CCTO:000148(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Pathological response rate''(time_t t0, time_t assessed_at) = probability(''Pathological response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000150 name: Hospital stay def: "The condition of being treated as a patient in a hospital." [NCIT:C25179] synonym: "Hospitalization" EXACT [NCIT:C25179] xref: UMLS:C0019993 xref: UMLS:C3489408 xref: NCIT:C25179 property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: schema "event_t CCTO:000150(time_t t0) = EVENT_STATE(CCTO:000150, t0)" xsd:string ! schema event_t ''Hospital stay''(time_t t0) = EVENT_STATE(''Hospital stay'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000035 ! Measure of healthcare resource utilization relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000151 name: Serious adverse events def: "Any expected or unexpected adverse event, related or unrelated to the intervention, occurring at any agent dose, any phase of product or procedure testing, that results in any of the following outcomes: death, a life-threatening adverse event, requires inpatient hospitalization (not required as part of the treatment) or prolongation of existing hospitalization, a persistent or significant disability or incapacity, or cancer, or a congenital anomaly or birth defect. Important medical events that may not result in the listed outcomes may be considered as serious when, based upon appropriate medical judgment, they represent significant hazards or potentially serious harm to the research subject or others and may require medical intervention to prevent one of the outcomes listed in this definition." [NCIT:C41335] synonym: "Grade 3 Through 5 Adverse Events That Are Related to Study Drug" [] synonym: "Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug" [] synonym: "SAE" EXACT [NCIT:C41335] synonym: "Serious adverse event" EXACT [NCIT:C41335] xref: UMLS:C1519255 xref: NCIT:C41335 property_value: ESCORT_rule "CCTO:000151 implies CCTO:000049" xsd:string ! ESCORT_rule ''Serious adverse events'' implies ''Adverse events'' property_value: schema "event_t CCTO:000151(time_t t0) = EVENT_STATE(CCTO:000151, t0)" xsd:string ! schema event_t ''Serious adverse events''(time_t t0) = EVENT_STATE(''Serious adverse events'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000152 name: Postoperative pain def: "A sensation of discomfort secondary to surgery." [NCIT:C34887] synonym: "Post-operative pain" EXACT [NCIT:C34887] xref: UMLS:C0030201 xref: NCIT:C34887 property_value: ESCORT_rule "CCTO:000152 implies CCTO:000098" xsd:string ! ESCORT_rule ''Postoperative pain'' implies ''Treatment-related adverse events '' property_value: ESCORT_rule "CCTO:000152 implies CCTO:000107" xsd:string ! ESCORT_rule ''Postoperative pain'' implies ''Pain'' property_value: schema "event_t CCTO:000152(time_t t0) = EVENT_STATE(CCTO:000152, t0)" xsd:string ! schema event_t ''Postoperative pain''(time_t t0) = EVENT_STATE(''Postoperative pain'', t0) is_a: CCTO:000098 ! Treatment-related adverse events is_a: CCTO:000107 ! Pain relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000153 name: Local recurrence property_value: ESCORT_rule "CCTO:000153 implies CCTO:000056" xsd:string ! ESCORT_rule ''Local recurrence'' implies ''Has local disease'' property_value: ESCORT_rule "CCTO:000153 implies CCTO:000087" xsd:string ! ESCORT_rule ''Local recurrence'' implies ''Recurrence'' property_value: ESCORT_rule "CCTO:000153 implies CCTO:001131 " xsd:string ! ESCORT_rule ''Local recurrence'' implies ''Locoregional recurrence'' property_value: ESCORT_rule "CCTO:000153 implies NOT CCTO:000106" xsd:string ! ESCORT_rule ''Local recurrence'' implies NOT ''Local control'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000153(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000153, t0, assessed_at)" xsd:string ! schema event_t ''Local recurrence''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Local recurrence'', t0, assessed_at) is_a: CCTO:000087 ! Recurrence relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000154 name: Local recurrence rate property_value: schema "probability_t CCTO:000154(time_t t0) = probability(CCTO:000153, t0)" xsd:string ! schema probability_t ''Local recurrence rate''(time_t t0) = probability(''Local recurrence'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000153 ! is_probability_of Local recurrence [Term] id: CCTO:000155 name: Complete resection property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000155(time_t t0) = EVENT_STATE(CCTO:000155, t0)" xsd:string ! schema event_t ''Complete resection''(time_t t0) = EVENT_STATE(''Complete resection'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000156 name: Complete resection rate property_value: schema "probability_t CCTO:000156(time_t t0) = probability(CCTO:000155, t0)" xsd:string ! schema probability_t ''Complete resection rate''(time_t t0) = probability(''Complete resection'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000155 ! is_probability_of Complete resection [Term] id: CCTO:000157 name: Pain score synonym: "Pain ratings" [] synonym: "Pain scores" [] property_value: ESCORT_rule "CCTO:000157 implies CCTO:000043" xsd:string ! ESCORT_rule ''Pain score'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000157 implies CCTO:000118" xsd:string ! ESCORT_rule ''Pain score'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000157(time_t t0) = EVENT_STATE(CCTO:000157, t0)" xsd:string ! schema event_t ''Pain score''(time_t t0) = EVENT_STATE(''Pain score'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes xref: UMLS:C0582148 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000217 ! is_assessed_by Visual analogue scale [Term] id: CCTO:000158 name: Operative time synonym: "Operation time" [] synonym: "Procedure time" [] property_value: schema "duration_t CCTO:000158(time_t t0) = EVENT_STATE(CCTO:000158, t0)" xsd:string ! schema duration_t ''Operative time''(time_t t0) = EVENT_STATE(''Operative time'', t0) is_a: CCTO:000003 ! Duration is_a: CCTO:000035 ! Measure of healthcare resource utilization xref: UMLS:C3494201 relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000159 name: Radiographic response property_value: ESCORT_rule "CCTO:000159 implies NOT CCTO:000112" xsd:string ! ESCORT_rule ''Radiographic response'' implies NOT ''Radiographic progression'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000159(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000159, t0, assessed_at)" xsd:string ! schema event_t ''Radiographic response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Radiographic response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000112 ! Radiographic progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000160 name: Duration of clinical benefit property_value: schema "duration_t CCTO:000160(time_t t0) = duration_of_event(CCTO:000078, t0)" xsd:string ! schema duration_t ''Duration of clinical benefit''(time_t t0) = duration_of_event(''Clinical benefit'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000078 ! is_duration_of Clinical benefit [Term] id: CCTO:000161 name: Complication rate synonym: "Complication rates" [] property_value: schema "probability_t CCTO:000161(time_t t0) = probability(CCTO:000137, t0)" xsd:string ! schema probability_t ''Complication rate''(time_t t0) = probability(''Complications'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000137 ! is_probability_of Complications [Term] id: CCTO:000162 name: Local recurrence-free survival property_value: ESCORT_rule "CCTO:000162 = time-to-first CCTO:000114 CCTO:000153" xsd:string ! ESCORT_rule ''Local recurrence-free survival'' = time-to-first ''Death'' ''Local recurrence'' property_value: schema "duration_t CCTO:000162(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000153) )" xsd:string ! schema duration_t ''Local recurrence-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Local recurrence'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000163 name: Resection def: "The act of cutting out; the surgical removal of part or all of a structure or organ." [NCIT:C15232] synonym: "Abscission" EXACT [NCIT:C15232] synonym: "Excision" EXACT [NCIT:C15232] synonym: "Excisional" EXACT [NCIT:C15232] synonym: "Extirpation" EXACT [NCIT:C15232] synonym: "Removal" EXACT [NCIT:C15232] synonym: "Surgical removal" EXACT [NCIT:C15232] xref: UMLS:C0728940 xref: UMLS:C0015252 xref: UMLS:C1177284 xref: UMLS:C0185115 xref: NCIT:C15232 property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000163(time_t t0) = EVENT_STATE(CCTO:000163, t0)" xsd:string ! schema event_t ''Resection''(time_t t0) = EVENT_STATE(''Resection'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000164 name: Resection rate property_value: schema "probability_t CCTO:000164(time_t t0) = probability(CCTO:000163, t0)" xsd:string ! schema probability_t ''Resection rate''(time_t t0) = probability(''Resection'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000163 ! is_probability_of Resection [Term] id: CCTO:000165 name: Progression-free rate property_value: schema "probability_t CCTO:000165(time_t t0) = probability(CCTO:000144, t0)" xsd:string ! schema probability_t ''Progression-free rate''(time_t t0) = probability(''Progression-free'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000144 ! is_probability_of Progression-free [Term] id: CCTO:000166 name: Skeletal-related event synonym: "Skeletal system" EXACT [NCIT:C12788] synonym: "Skeletal-related events" [] synonym: "Skeleton" EXACT [NCIT:C12788] synonym: "skeletal" EXACT [NCIT:C12788] xref: UMLS:C0037253 xref: UMLS:C0521324 xref: UMLS:C0816871 xref: UMLS:C3540776 xref: NCIT:C12788 property_value: ESCORT_rule "CCTO:000166 implies CCTO:000049" xsd:string ! ESCORT_rule ''Skeletal-related event'' implies ''Adverse events'' property_value: schema "event_t CCTO:000166(time_t t0) = EVENT_STATE(CCTO:000166, t0)" xsd:string ! schema event_t ''Skeletal-related event''(time_t t0) = EVENT_STATE(''Skeletal-related event'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000167 name: Time to first skeletal-related event property_value: ESCORT_rule "CCTO:000167 = time-to-first CCTO:000166" xsd:string ! ESCORT_rule ''Time to first skeletal-related event'' = time-to-first ''Skeletal-related event'' property_value: schema "duration_t CCTO:000167(time_t t0) = time_to_first_event(CCTO:000166, t0)" xsd:string ! schema duration_t ''Time to first skeletal-related event''(time_t t0) = time_to_first_event(''Skeletal-related event'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000168 name: Recurrence-free property_value: ESCORT_rule "CCTO:000168 implies NOT CCTO:000087" xsd:string ! ESCORT_rule ''Recurrence-free'' implies NOT ''Recurrence'' property_value: ESCORT_rule "NOT CCTO:000168 implies CCTO:000087" xsd:string ! ESCORT_rule NOT ''Recurrence-free'' implies ''Recurrence'' property_value: schema "event_t CCTO:000168(time_t t0, time_t assessed_at) = NOT CCTO:000087(t0, assessed_at)" xsd:string ! schema event_t ''Recurrence-free''(time_t t0, time_t assessed_at) = NOT ''Recurrence''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000087 ! Recurrence relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000087 ! is_opposite_of Recurrence [Term] id: CCTO:000169 name: Cosmetic outcome synonym: "cosmetic results" [] property_value: schema "event_t CCTO:000169(time_t t0) = EVENT_STATE(CCTO:000169, t0)" xsd:string ! schema event_t ''Cosmetic outcome''(time_t t0) = EVENT_STATE(''Cosmetic outcome'', t0) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000170 name: Time to local recurrence property_value: ESCORT_rule "CCTO:000170 = time-to-first CCTO:000153" xsd:string ! ESCORT_rule ''Time to local recurrence'' = time-to-first ''Local recurrence'' property_value: schema "duration_t CCTO:000170(time_t t0) = time_to_first_event(CCTO:000153, t0)" xsd:string ! schema duration_t ''Time to local recurrence''(time_t t0) = time_to_first_event(''Local recurrence'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000171 name: Local-regional control synonym: "Loco-regional control" [] synonym: "Locoregional control" [] property_value: ESCORT_rule "CCTO:000171 implies CCTO:000106 " xsd:string ! ESCORT_rule ''Local-regional control'' implies ''Local control'' property_value: ESCORT_rule "CCTO:000171 implies CCTO:001133" xsd:string ! ESCORT_rule ''Local-regional control'' implies ''Regional control'' property_value: ESCORT_rule "CCTO:000171 implies NOT CCTO:000211" xsd:string ! ESCORT_rule ''Local-regional control'' implies NOT ''Locoregional failure'' property_value: ESCORT_rule "CCTO:000171 implies NOT CCTO:001131" xsd:string ! ESCORT_rule ''Local-regional control'' implies NOT ''Locoregional recurrence'' property_value: ESCORT_rule "CCTO:000171 is-intersection-of CCTO:000106 CCTO:001133" xsd:string ! ESCORT_rule ''Local-regional control'' is-intersection-of ''Local control'' ''Regional control'' property_value: ESCORT_rule "NOT CCTO:000106 implies NOT CCTO:000171" xsd:string ! ESCORT_rule NOT ''Local control'' implies NOT ''Local-regional control'' property_value: ESCORT_rule "NOT CCTO:001133 implies NOT CCTO:000171" xsd:string ! ESCORT_rule NOT ''Regional control'' implies NOT ''Local-regional control'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000171(time_t t0) = EVENT_STATE(CCTO:000171, t0)" xsd:string ! schema event_t ''Local-regional control''(time_t t0) = EVENT_STATE(''Local-regional control'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy intersection_of: CCTO:000106 ! Local control intersection_of: CCTO:001133 ! Regional control disjoint_from: CCTO:000211 ! Locoregional failure disjoint_from: CCTO:001131 ! Locoregional recurrence relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000172 name: Pain intensity def: "A question about the intensity of an individual's pain." [NCIT:C124175] synonym: "Pain distress" EXACT [NCIT:C124175] synonym: "Pain severity" EXACT [NCIT:C124175] synonym: "Severity of Pain" EXACT [NCIT:C124175] xref: UMLS:C1320357 xref: UMLS:C1507013 xref: NCIT:C124175 property_value: ESCORT_rule "CCTO:000172 implies CCTO:000043" xsd:string ! ESCORT_rule ''Pain intensity'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000172 implies CCTO:000118" xsd:string ! ESCORT_rule ''Pain intensity'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000172(time_t t0) = EVENT_STATE(CCTO:000172, t0)" xsd:string ! schema event_t ''Pain intensity''(time_t t0) = EVENT_STATE(''Pain intensity'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000173 name: Duration of PSA response property_value: schema "duration_t CCTO:000173(time_t t0) = duration_of_event(CCTO:000120, t0)" xsd:string ! schema duration_t ''Duration of PSA response''(time_t t0) = duration_of_event(''PSA response'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000120 ! is_duration_of PSA response [Term] id: CCTO:000174 name: Clinical progression-free survival property_value: schema "duration_t CCTO:000174(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000175) )" xsd:string ! schema duration_t ''Clinical progression-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Clinical progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000175 name: Clinical progression property_value: ESCORT_rule "CCTO:000175 implies NOT CCTO:000092" xsd:string ! ESCORT_rule ''Clinical progression'' implies NOT ''Clinical response'' property_value: schema "event_t CCTO:000175(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000175, t0, assessed_at)" xsd:string ! schema event_t ''Clinical progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Clinical progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000092 ! Clinical response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000176 name: Duration of complete response property_value: ESCORT_rule "CCTO:000176 = measured-from-first CCTO:000082 time-to-first-not CCTO:000082" xsd:string ! ESCORT_rule ''Duration of complete response'' = measured-from-first ''Complete response'' time-to-first-not ''Complete response'' property_value: schema "duration_t CCTO:000176(time_t t0) = duration_of_event(CCTO:000082, t0)" xsd:string ! schema duration_t ''Duration of complete response''(time_t t0) = duration_of_event(''Complete response'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000082 ! is_duration_of Complete response [Term] id: CCTO:000177 name: Blood loss def: "Loss of blood from the circulation, either internally or externally." [NCIT:C50470] synonym: "Estimated blood loss" [] synonym: "Loss of blood" EXACT [NCIT:C50470] xref: UMLS:C3163616 xref: UMLS:C0553700 xref: UMLS:C1443559 xref: NCIT:C50470 property_value: ESCORT_rule "CCTO:000177 implies CCTO:000098" xsd:string ! ESCORT_rule ''Blood loss'' implies ''Treatment-related adverse events '' property_value: schema "event_t CCTO:000177(time_t t0) = EVENT_STATE(CCTO:000177, t0)" xsd:string ! schema event_t ''Blood loss''(time_t t0) = EVENT_STATE(''Blood loss'', t0) is_a: CCTO:000098 ! Treatment-related adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000178 name: Pain response property_value: ESCORT_rule "CCTO:000178 implies CCTO:000043" xsd:string ! ESCORT_rule ''Pain response'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000178 implies NOT CCTO:000130" xsd:string ! ESCORT_rule ''Pain response'' implies NOT ''Pain progression'' property_value: schema "event_t CCTO:000178(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000178, t0, assessed_at)" xsd:string ! schema event_t ''Pain response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Pain response'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety disjoint_from: CCTO:000130 ! Pain progression xref: UMLS:C0424543 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000179 name: Surgical complications property_value: ESCORT_rule "CCTO:000179 implies CCTO:000098" xsd:string ! ESCORT_rule ''Surgical complications'' implies ''Treatment-related adverse events '' property_value: schema "event_t CCTO:000179(time_t t0) = EVENT_STATE(CCTO:000179, t0)" xsd:string ! schema event_t ''Surgical complications''(time_t t0) = EVENT_STATE(''Surgical complications'', t0) is_a: CCTO:000098 ! Treatment-related adverse events xref: UMLS:C0221082 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000180 name: Hospital Anxiety and Depression Scale property_value: ESCORT_rule "CCTO:000180 implies CCTO:000043" xsd:string ! ESCORT_rule ''Hospital Anxiety and Depression Scale'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000180 implies CCTO:000118" xsd:string ! ESCORT_rule ''Hospital Anxiety and Depression Scale'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000180(time_t t0) = EVENT_STATE(CCTO:000180, t0)" xsd:string ! schema event_t ''Hospital Anxiety and Depression Scale''(time_t t0) = EVENT_STATE(''Hospital Anxiety and Depression Scale'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000181 name: Symptomatic progression synonym: "Symptom progression" [] property_value: schema "event_t CCTO:000181(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000181, t0, assessed_at)" xsd:string ! schema event_t ''Symptomatic progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Symptomatic progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000182 name: Time to symptomatic progression synonym: "Time to Symptom Progression" [] property_value: schema "duration_t CCTO:000182(time_t t0) = time_to_first_event(CCTO:000181, t0)" xsd:string ! schema duration_t ''Time to symptomatic progression''(time_t t0) = time_to_first_event(''Symptomatic progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000183 name: Progression rate property_value: schema "probability_t CCTO:000183(time_t t0, time_t assessed_at) = probability(CCTO:000064(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Progression rate''(time_t t0, time_t assessed_at) = probability(''Disease progression''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000184 name: Toxicity rate synonym: "Overall toxicity rate" [] synonym: "Toxicity rates" [] property_value: schema "probability_t CCTO:000184(time_t t0) = probability(CCTO:000048, t0)" xsd:string ! schema probability_t ''Toxicity rate''(time_t t0) = probability(''Toxicity'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000048 ! is_probability_of Toxicity [Term] id: CCTO:000185 name: Positive and Negative Affect Schedule property_value: ESCORT_rule "CCTO:000185 implies CCTO:000043" xsd:string ! ESCORT_rule ''Positive and Negative Affect Schedule'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000185 implies CCTO:000118" xsd:string ! ESCORT_rule ''Positive and Negative Affect Schedule'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000185(time_t t0) = EVENT_STATE(CCTO:000185, t0)" xsd:string ! schema event_t ''Positive and Negative Affect Schedule''(time_t t0) = EVENT_STATE(''Positive and Negative Affect Schedule'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000186 name: Complete clearance property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000186(time_t t0) = EVENT_STATE(CCTO:000186, t0)" xsd:string ! schema event_t ''Complete clearance''(time_t t0) = EVENT_STATE(''Complete clearance'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000187 name: Complete clearance rate property_value: schema "probability_t CCTO:000187(time_t t0) = probability(CCTO:000186, t0)" xsd:string ! schema probability_t ''Complete clearance rate''(time_t t0) = probability(''Complete clearance'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000186 ! is_probability_of Complete clearance [Term] id: CCTO:000188 name: Depression def: "A melancholy feeling of sadness and despair OR A disorder characterized by melancholic feelings of grief or unhappiness." [NCIT:C2982, NCI:CTCAE] xref: UMLS:C1999266 xref: UMLS:C0011570 xref: UMLS:C0011581 xref: NCI:CTCAE:10012378 xref: NCIT:C2982 property_value: ESCORT_rule "CCTO:000188 implies CCTO:000049" xsd:string ! ESCORT_rule ''Depression'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000188 implies CCTO:001105" xsd:string ! ESCORT_rule ''Depression'' implies ''Psychiatric disorders'' is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000180 ! is_assessed_by Hospital Anxiety and Depression Scale relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000189 name: Distant failure-free survival property_value: ESCORT_rule "CCTO:000189 = time-to-first CCTO:000114 CCTO:000190" xsd:string ! ESCORT_rule ''Distant failure-free survival'' = time-to-first ''Death'' ''Distant failure'' property_value: schema "duration_t CCTO:000189(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000190) )" xsd:string ! schema duration_t ''Distant failure-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Distant failure'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000190 name: Distant failure property_value: ESCORT_rule "CCTO:000190 implies CCTO:000058" xsd:string ! ESCORT_rule ''Distant failure'' implies ''Has metastasis'' property_value: schema "event_t CCTO:000190(time_t t0) = EVENT_STATE(CCTO:000190, t0)" xsd:string ! schema event_t ''Distant failure''(time_t t0) = EVENT_STATE(''Distant failure'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000191 name: Surgical morbidity synonym: "Operative morbidity" [] synonym: "Post-operative morbidity" [] synonym: "Postoperative morbidity" [] property_value: ESCORT_rule "CCTO:000191 implies CCTO:000098" xsd:string ! ESCORT_rule ''Surgical morbidity'' implies ''Treatment-related adverse events '' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000037 ! Measure of performance status is_a: CCTO:000098 ! Treatment-related adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000192 name: Karnofsky Performance Status def: "An index designed for classifying patients 16 years of age or older by their functional impairment." [NCIT:C28013] synonym: "KPS" EXACT [NCIT:C28013] synonym: "Karnofsky Performance Scale" [] synonym: "Karnofsky scale" EXACT [NCIT:C28013] synonym: "Karnofsky" EXACT [NCIT:C28013] xref: UMLS:C0206065 xref: NCIT:C28013 property_value: schema "event_t CCTO:000192(time_t t0) = EVENT_STATE(CCTO:000192, t0)" xsd:string ! schema event_t ''Karnofsky Performance Status''(time_t t0) = EVENT_STATE(''Karnofsky Performance Status'', t0) is_a: CCTO:000037 ! Measure of performance status is_a: CCTO:000053 ! Clinical criteria relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000193 name: Overall remission rate synonym: "Remission rate" [] property_value: schema "probability_t CCTO:000193(time_t t0) = probability(CCTO:000134, t0)" xsd:string ! schema probability_t ''Overall remission rate''(time_t t0) = probability(''Remission'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000134 ! is_probability_of Remission [Term] id: CCTO:000194 name: Quality of life questionnaire synonym: "Quality of life score" [] property_value: ESCORT_rule "CCTO:000194 implies CCTO:000118" xsd:string ! ESCORT_rule ''Quality of life questionnaire'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000194(time_t t0) = EVENT_STATE(CCTO:000194, t0)" xsd:string ! schema event_t ''Quality of life questionnaire''(time_t t0) = EVENT_STATE(''Quality of life questionnaire'', t0) is_a: CCTO:000023 ! Measure of quality of life is_a: CCTO:000118 ! Patient reported outcomes xref: UMLS:C3476431 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000195 name: Immune-related progression-free survival property_value: ESCORT_rule "CCTO:000195 = time-to-first CCTO:000114 CCTO:000196" xsd:string ! ESCORT_rule ''Immune-related progression-free survival'' = time-to-first ''Death'' ''Immune-related progression'' property_value: schema "duration_t CCTO:000195(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000196) )" xsd:string ! schema duration_t ''Immune-related progression-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Immune-related progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000196 name: Immune-related progression def: "Protected against infectious disease by either specific or non-specific mechanisms." [NCIT:C17997] synonym: "Immune" EXACT [NCIT:C17997] xref: UMLS:C0439662 xref: NCIT:C17997 property_value: ESCORT_rule "CCTO:000196 implies CCTO:000064" xsd:string ! ESCORT_rule ''Immune-related progression'' implies ''Disease progression'' property_value: ESCORT_rule "CCTO:000196 implies NOT CCTO:000344" xsd:string ! ESCORT_rule ''Immune-related progression'' implies NOT ''Immune-related objective response'' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000344 ! Immune-related objective response relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000197 name: Resectability property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000197(time_t t0) = EVENT_STATE(CCTO:000197, t0)" xsd:string ! schema event_t ''Resectability''(time_t t0) = EVENT_STATE(''Resectability'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000198 name: Resectability rate property_value: schema "probability_t CCTO:000198(time_t t0) = probability(CCTO:000197, t0)" xsd:string ! schema probability_t ''Resectability rate''(time_t t0) = probability(''Resectability'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000197 ! is_probability_of Resectability [Term] id: CCTO:000199 name: Breast conservation property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000199(time_t t0) = EVENT_STATE(CCTO:000199, t0)" xsd:string ! schema event_t ''Breast conservation''(time_t t0) = EVENT_STATE(''Breast conservation'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000200 name: Breast conservation rate property_value: schema "probability_t CCTO:000200(time_t t0) = probability(CCTO:000199, t0)" xsd:string ! schema probability_t ''Breast conservation rate''(time_t t0) = probability(''Breast conservation'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000199 ! is_probability_of Breast conservation [Term] id: CCTO:000201 name: Partial response def: "A finding indicating that there is a decrease in the size and the extent of tissue involvement by a malignant tumor in a patient." [NCIT:C18058] synonym: "Partial remission" EXACT [NCIT:C18058] xref: UMLS:C1521726 xref: NCIT:C18058 xref: NCIT:C18212 property_value: ESCORT_rule "CCTO:000201 implies CCTO:000065" xsd:string ! ESCORT_rule ''Partial response'' implies ''Treatment response'' property_value: ESCORT_rule "CCTO:000201 implies CCTO:000070" xsd:string ! ESCORT_rule ''Partial response'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000201 implies NOT CCTO:000064" xsd:string ! ESCORT_rule ''Partial response'' implies NOT ''Disease progression'' property_value: ESCORT_rule "CCTO:000201 implies NOT CCTO:000082" xsd:string ! ESCORT_rule ''Partial response'' implies NOT ''Complete response'' property_value: ESCORT_rule "CCTO:000201 implies NOT CCTO:000099" xsd:string ! ESCORT_rule ''Partial response'' implies NOT ''Stable disease'' property_value: schema "event_t CCTO:000201(time_t t0) = EVENT_STATE(CCTO:000201, t0)" xsd:string ! schema event_t ''Partial response''(time_t t0) = EVENT_STATE(''Partial response'', t0) property_value: schema "event_t CCTO:000201(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000201, t0, assessed_at)" xsd:string ! schema event_t ''Partial response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Partial response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000064 ! Disease progression disjoint_from: CCTO:000082 ! Complete response disjoint_from: CCTO:000099 ! Stable disease relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000349 ! is_assessed_by Response Evaluation Criteria in Solid Tumors [Term] id: CCTO:000202 name: Time to clinical progression property_value: ESCORT_rule "CCTO:000202 = time-to-first CCTO:000175" xsd:string ! ESCORT_rule ''Time to clinical progression'' = time-to-first ''Clinical progression'' property_value: schema "duration_t CCTO:000202(time_t t0) = time_to_first_event(CCTO:000175, t0)" xsd:string ! schema duration_t ''Time to clinical progression''(time_t t0) = time_to_first_event(''Clinical progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000203 name: Time to best response property_value: schema "duration_t CCTO:000203(time_t t0) = time_to_first_event(CCTO:000089, t0)" xsd:string ! schema duration_t ''Time to best response''(time_t t0) = time_to_first_event(''Best overall response'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000204 name: Partial clearance property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000204(time_t t0) = EVENT_STATE(CCTO:000204, t0)" xsd:string ! schema event_t ''Partial clearance''(time_t t0) = EVENT_STATE(''Partial clearance'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000205 name: Partial clearance rate property_value: schema "probability_t CCTO:000205(time_t t0) = probability(CCTO:000204, t0)" xsd:string ! schema probability_t ''Partial clearance rate''(time_t t0) = probability(''Partial clearance'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000204 ! is_probability_of Partial clearance [Term] id: CCTO:000206 name: Deterioration def: "A symptom or state of reduced quality or strength." [NCIT:C25751] xref: UMLS:C0868945 xref: NCIT:C25751 property_value: schema "event_t CCTO:000206(time_t t0) = EVENT_STATE(CCTO:000206, t0)" xsd:string ! schema event_t ''Deterioration''(time_t t0) = EVENT_STATE(''Deterioration'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000207 name: Time to deterioration property_value: schema "duration_t CCTO:000207(time_t t0) = time_to_first_event(CCTO:000206, t0)" xsd:string ! schema duration_t ''Time to deterioration''(time_t t0) = time_to_first_event(''Deterioration'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000208 name: Event-free survival rate property_value: schema "probability_t CCTO:000208(time_t t0, time_t assessed_at) = probability(CCTO:000071(t0), assessed_at)" xsd:string ! schema probability_t ''Event-free survival rate''(time_t t0, time_t assessed_at) = probability(''Event-free survival''(t0), assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000011 CCTO:000071 ! is_timed_observation_of Event-free survival [Term] id: CCTO:000209 name: Weight def: "The vertical force exerted by a mass as a result of gravity OR The relative importance granted to something." [NCIT:C25208, NCIT:C48192] synonym: "Importance weight" EXACT [NCIT:C48192] synonym: "weighting" EXACT [NCIT:C48192] xref: UMLS:C1305866 xref: UMLS:C0005910 xref: UMLS:C0043100 xref: UMLS:C1705104 xref: UMLS:C0944911 xref: NCIT:C25208 xref: NCIT:C48192 property_value: ESCORT_rule "CCTO:000209 implies CCTO:000043" xsd:string ! ESCORT_rule ''Weight'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000209(time_t t0) = EVENT_STATE(CCTO:000209, t0)" xsd:string ! schema event_t ''Weight''(time_t t0) = EVENT_STATE(''Weight'', t0) is_a: CCTO:000033 ! Measure of nutritional status is_a: CCTO:000043 ! Measure of safety is_a: CCTO:001132 ! Anthropometry relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000210 name: Locoregional failure-free survival property_value: ESCORT_rule "CCTO:000210 = time-to-first CCTO:000114 CCTO:000211" xsd:string ! ESCORT_rule ''Locoregional failure-free survival'' = time-to-first ''Death'' ''Locoregional failure'' property_value: schema "duration_t CCTO:000210(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000211) )" xsd:string ! schema duration_t ''Locoregional failure-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Locoregional failure'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000211 name: Locoregional failure synonym: "Local-regional failure" [] property_value: ESCORT_rule "CCTO:000153 implies CCTO:000211" xsd:string ! ESCORT_rule ''Local recurrence'' implies ''Locoregional failure'' property_value: ESCORT_rule "CCTO:000211 implies NOT CCTO:000171" xsd:string ! ESCORT_rule ''Locoregional failure'' implies NOT ''Local-regional control'' property_value: ESCORT_rule "CCTO:000211 is-union-of CCTO:000153 CCTO:001104" xsd:string ! ESCORT_rule ''Locoregional failure'' is-union-of ''Local recurrence'' ''Regional recurrence'' property_value: ESCORT_rule "CCTO:001104 implies CCTO:000211" xsd:string ! ESCORT_rule ''Regional recurrence'' implies ''Locoregional failure'' property_value: schema "event_t CCTO:000211(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000211, t0, assessed_at)" xsd:string ! schema event_t ''Locoregional failure''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Locoregional failure'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy union_of: CCTO:000153 ! Local recurrence union_of: CCTO:001104 ! Regional recurrence disjoint_from: CCTO:000171 ! Local-regional control relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000212 name: Erythema def: "Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease." [NCIT:C26901] synonym: "Redness" EXACT [NCIT:C26901] xref: UMLS:C0041834 xref: UMLS:C1260956 xref: UMLS:C0332575 xref: NCIT:C26901 property_value: ESCORT_rule "CCTO:000212 implies CCTO:000049" xsd:string ! ESCORT_rule ''Erythema'' implies ''Adverse events'' property_value: schema "event_t CCTO:000212(time_t t0) = EVENT_STATE(CCTO:000212, t0)" xsd:string ! schema event_t ''Erythema''(time_t t0) = EVENT_STATE(''Erythema'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000213 name: Tumor markers def: "A substance present in or produced by a tumor or by the host, that can be used for differentiating neoplastic from normal tissue based on measurements in body fluids, secretions, cells, and/or tissues. Markers are used in diagnosis, staging and prognosis of cancer, provide an estimation of tumor burden, and serve for monitoring effects of therapy, detecting recurrence, localization of tumors, and screening in general populations." [NCIT:C17220] synonym: "Tumor marker" EXACT [NCIT:C17220] xref: UMLS:C0041365 xref: UMLS:C1139415 xref: NCIT:C17220 property_value: ESCORT_rule "CCTO:000213 implies CCTO:000051" xsd:string ! ESCORT_rule ''Tumor markers'' implies ''Investigation'' property_value: schema "event_t CCTO:000213(time_t t0) = EVENT_STATE(CCTO:000213, t0)" xsd:string ! schema event_t ''Tumor markers''(time_t t0) = EVENT_STATE(''Tumor markers'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000051 ! Investigation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000214 name: Distant recurrence-free property_value: schema "event_t CCTO:000214(time_t t0, time_t assessed_at) = NOT CCTO:000215(t0, assessed_at)" xsd:string ! schema event_t ''Distant recurrence-free''(time_t t0, time_t assessed_at) = NOT ''Distant recurrence''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000215 ! is_opposite_of Distant recurrence [Term] id: CCTO:000215 name: Distant recurrence property_value: ESCORT_rule "CCTO:000215 implies CCTO:000058" xsd:string ! ESCORT_rule ''Distant recurrence'' implies ''Has metastasis'' property_value: ESCORT_rule "CCTO:000215 implies CCTO:000087" xsd:string ! ESCORT_rule ''Distant recurrence'' implies ''Recurrence'' property_value: ESCORT_rule "CCTO:000215 implies CCTO:000190" xsd:string ! ESCORT_rule ''Distant recurrence'' implies ''Distant failure'' property_value: schema "event_t CCTO:000215(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000215, t0, assessed_at)" xsd:string ! schema event_t ''Distant recurrence''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Distant recurrence'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000214 ! Distant recurrence-free relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000214 ! is_opposite_of Distant recurrence-free [Term] id: CCTO:000216 name: Distant recurrence-free interval property_value: schema "duration_t CCTO:000216(time_t t0) = time_to_first_event(CCTO:000215, t0)" xsd:string ! schema duration_t ''Distant recurrence-free interval''(time_t t0) = time_to_first_event(''Distant recurrence'', t0) is_a: CCTO:000003 ! Duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000217 name: Visual analogue scale def: "A psychometric response scale to assess subjective characteristics or symptoms, which relies upon a continuum of possible result values in between two fixed end-points." [NCIT:C121547] synonym: "VAS" EXACT [NCIT:C121547] synonym: "Visual analog scale" EXACT [NCIT:C121547] xref: UMLS:C0042815 xref: UMLS:C3536884 xref: NCIT:C121547 property_value: ESCORT_rule "CCTO:000217 implies CCTO:000043" xsd:string ! ESCORT_rule ''Visual analogue scale'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000217 implies CCTO:000118" xsd:string ! ESCORT_rule ''Visual analogue scale'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000217(time_t t0) = EVENT_STATE(CCTO:000217, t0)" xsd:string ! schema event_t ''Visual analogue scale''(time_t t0) = EVENT_STATE(''Visual analogue scale'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000218 name: Disease-free property_value: ESCORT_rule "CCTO:000218 implies CCTO:000073" xsd:string ! ESCORT_rule ''Disease-free'' implies ''Disease Control'' property_value: ESCORT_rule "CCTO:000218 implies CCTO:000106" xsd:string ! ESCORT_rule ''Disease-free'' implies ''Local control'' property_value: ESCORT_rule "CCTO:000218 implies CCTO:001133" xsd:string ! ESCORT_rule ''Disease-free'' implies ''Regional control'' property_value: ESCORT_rule "CCTO:000218 implies NOT CCTO:000056" xsd:string ! ESCORT_rule ''Disease-free'' implies NOT ''Has local disease'' property_value: ESCORT_rule "CCTO:000218 implies NOT CCTO:000057" xsd:string ! ESCORT_rule ''Disease-free'' implies NOT ''Has regional disease'' property_value: ESCORT_rule "CCTO:000218 implies NOT CCTO:000058" xsd:string ! ESCORT_rule ''Disease-free'' implies NOT ''Has metastasis'' property_value: ESCORT_rule "CCTO:000218 implies NOT CCTO:000070" xsd:string ! ESCORT_rule ''Disease-free'' implies NOT ''Has disease'' property_value: ESCORT_rule "NOT CCTO:000218 implies CCTO:000070" xsd:string ! ESCORT_rule NOT ''Disease-free'' implies ''Has disease'' property_value: schema "event_t CCTO:000218(time_t t0) = NOT EVENT_STATE(CCTO:000070, t0)" xsd:string ! schema event_t ''Disease-free''(time_t t0) = NOT EVENT_STATE(''Has disease'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000058 ! Has metastasis disjoint_from: CCTO:000070 ! Has disease relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000070 ! is_opposite_of Has disease [Term] id: CCTO:000219 name: Disease-free interval property_value: ESCORT_rule "CCTO:000219 = measured-from-first CCTO:000218 time-to-first CCTO:000070" xsd:string ! ESCORT_rule ''Disease-free interval'' = measured-from-first ''Disease-free'' time-to-first ''Has disease'' property_value: schema "duration_t CCTO:000219(time_t t0) = time_to_first_event(CCTO:000070, t0)" xsd:string ! schema duration_t ''Disease-free interval''(time_t t0) = time_to_first_event(''Has disease'', t0) is_a: CCTO:000003 ! Duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000220 name: Partial response rate property_value: schema "probability_t CCTO:000220(time_t t0, time_t assessed_at) = probability(CCTO:000201(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Partial response rate''(time_t t0, time_t assessed_at) = probability(''Partial response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000221 name: Stable disease rate property_value: schema "probability_t CCTO:000221(time_t t0) = probability(CCTO:000099, t0)" xsd:string ! schema probability_t ''Stable disease rate''(time_t t0) = probability(''Stable disease'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000099 ! is_probability_of Stable disease [Term] id: CCTO:000222 name: Treatment-free survival property_value: ESCORT_rule "CCTO:000222 = time-to-first CCTO:000114 CCTO:000223" xsd:string ! ESCORT_rule ''Treatment-free survival'' = time-to-first ''Death'' ''On treatment'' property_value: schema "duration_t CCTO:000222(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000223) )" xsd:string ! schema duration_t ''Treatment-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''On treatment'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000223 name: On treatment def: "A period in a clinical study during which subjects receive therapeutic treatment OR An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process OR The act of the dispensing, applying, or tendering of something to another, such as administration of a medicine OR Subject to a process with the aim of readying for some purpose, improving, or remedying a condition OR An action or administration of therapeutic agents to produce an effect that is intended to alter the course of a pathologic process." [NCIT:C101526, NCIT:C49236, NCIT:C25409, NCIT:C70742, NCIT:C15368] synonym: "Administration" EXACT [NCIT:C25409] synonym: "TX" EXACT [NCIT:C15368] synonym: "TX" EXACT [NCIT:C49236] synonym: "Therapeutic interventions" EXACT [NCIT:C15368] synonym: "Therapeutic interventions" EXACT [NCIT:C49236] synonym: "Therapeutic method" EXACT [NCIT:C49236] synonym: "Therapeutic procedure" EXACT [NCIT:C15368] synonym: "Therapeutic procedure" EXACT [NCIT:C49236] synonym: "Therapeutic technique" EXACT [NCIT:C49236] synonym: "Therapy" EXACT [NCIT:C15368] synonym: "Therapy" EXACT [NCIT:C49236] synonym: "Treat" EXACT [NCIT:C70742] synonym: "Treated" EXACT [NCIT:C70742] synonym: "Treatment epoch" EXACT [NCIT:C101526] synonym: "Treatment" EXACT [NCIT:C15368] synonym: "Treatment" EXACT [NCIT:C25409] synonym: "Treatment" EXACT [NCIT:C49236] synonym: "Treatment" EXACT [NCIT:C70742] xref: UMLS:C0087111 xref: UMLS:C1705169 xref: UMLS:C3161471 xref: UMLS:C1522326 xref: UMLS:C0001554 xref: UMLS:C0808232 xref: UMLS:C0039798 xref: UMLS:C1292734 xref: UMLS:C3538994 xref: NCIT:C101526 xref: NCIT:C15368 xref: NCIT:C25409 xref: NCIT:C49236 xref: NCIT:C70742 property_value: schema "event_t CCTO:000223(time_t t0) = EVENT_STATE(CCTO:000223, t0)" xsd:string ! schema event_t ''On treatment''(time_t t0) = EVENT_STATE(''On treatment'', t0) is_a: CCTO:000006 ! Event state relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000224 name: Prostate cancer-specific survival property_value: ESCORT_rule "CCTO:000224 = time-to-first CCTO:001106" xsd:string ! ESCORT_rule ''Prostate cancer-specific survival'' = time-to-first ''Prostate cancer-specific death'' property_value: schema "duration_t CCTO:000224(time_t t0) = EVENT_STATE(CCTO:001106, t0) ? CCTO:000062(t0) : NULL" xsd:string ! schema duration_t ''Prostate cancer-specific survival''(time_t t0) = EVENT_STATE(''Prostate cancer-specific death'', t0) ? ''Overall survival''(t0) : NULL is_a: CCTO:000105 ! Disease-specific survival relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000225 name: Psychological distress property_value: ESCORT_rule "CCTO:000225 implies CCTO:000049" xsd:string ! ESCORT_rule ''Psychological distress'' implies ''Adverse events'' property_value: schema "unknown_t CCTO:000225(time_t t0) = EVENT_STATE(CCTO:000225, t0)" xsd:string ! schema unknown_t ''Psychological distress''(time_t t0) = EVENT_STATE(''Psychological distress'', t0) is_a: CCTO:000049 ! Adverse events xref: UMLS:C0815107 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000226 name: Edema def: "Accumulation of an excessive amount of fluid in cells or intercellular tissues." [NCIT:C3002] xref: UMLS:C0013604 xref: UMLS:C1717255 xref: NCIT:C3002 property_value: ESCORT_rule "CCTO:000226 implies CCTO:000049" xsd:string ! ESCORT_rule ''Edema'' implies ''Adverse events'' property_value: schema "event_t CCTO:000226(time_t t0) = EVENT_STATE(CCTO:000226, t0)" xsd:string ! schema event_t ''Edema''(time_t t0) = EVENT_STATE(''Edema'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000227 name: Early late toxicity property_value: schema "event_t CCTO:000227(time_t t0) = EVENT_STATE(CCTO:000227, t0)" xsd:string ! schema event_t ''Early late toxicity''(time_t t0) = EVENT_STATE(''Early late toxicity'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000228 name: Dermatology Life Quality Index property_value: ESCORT_rule "CCTO:000228 implies CCTO:000118" xsd:string ! ESCORT_rule ''Dermatology Life Quality Index'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000228(time_t t0) = EVENT_STATE(CCTO:000228, t0)" xsd:string ! schema event_t ''Dermatology Life Quality Index''(time_t t0) = EVENT_STATE(''Dermatology Life Quality Index'', t0) is_a: CCTO:000023 ! Measure of quality of life is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000229 name: Menopausal symptoms def: "Any of the mental or physical manifestations that accompany perimenopause and menopause." [NCIT:C3852] synonym: "Menopausal symptom" EXACT [NCIT:C3852] xref: UMLS:C0236075 xref: NCIT:C3852 property_value: ESCORT_rule "CCTO:000229 implies CCTO:000049" xsd:string ! ESCORT_rule ''Menopausal symptoms'' implies ''Adverse events'' property_value: schema "event_t CCTO:000229(time_t t0) = EVENT_STATE(CCTO:000229, t0)" xsd:string ! schema event_t ''Menopausal symptoms''(time_t t0) = EVENT_STATE(''Menopausal symptoms'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000230 name: Brief Pain Inventory def: "A tool for the assessment of pain in both clinical and research settings. The BPI uses simple numeric rating scales from 0 to 10 that are easy to understand and easy to translate into other languages. On the BPI, mild pain is defined as a worst pain score of 1 - 4, moderate pain is defined as a worst pain score of 5 - 6, and severe pain is defined as a worst pain score of 7-10 OR A standardized survey originally developed and copyrighted by Charles S. Cleeland in 1991 which is used to evaluate the severity of a patient's pain and the impact that their pain has on their daily activities. This longer version is more clinically useful, can be completed by the patient or in an interview format and consists of 32 multi-level questions covering areas such as location, type, and severity of pain as well as the use of pain medications." [NCIT:C18203, NCIT:C100759] synonym: "BPI" EXACT [NCIT:C100759] synonym: "BPI1" EXACT [NCIT:C100759] synonym: "Brief Pain Inventory Questionnaire" EXACT [NCIT:C100759] xref: UMLS:C1511326 xref: UMLS:C3539024 xref: UMLS:C1443145 xref: NCIT:C100759 xref: NCIT:C18203 property_value: ESCORT_rule "CCTO:000230 implies CCTO:000043" xsd:string ! ESCORT_rule ''Brief Pain Inventory'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000230 implies CCTO:000118" xsd:string ! ESCORT_rule ''Brief Pain Inventory'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000230(time_t t0) = EVENT_STATE(CCTO:000230, t0)" xsd:string ! schema event_t ''Brief Pain Inventory''(time_t t0) = EVENT_STATE(''Brief Pain Inventory'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000231 name: Weight loss def: "A reduction in total body weight OR A question about the usual severity of an individual's weight loss OR A question about how often an individual has or had weight loss OR A question about an individual's distress from their weight loss OR A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve OR A question about whether an individual has or had weight loss." [NCIT:C3445, NCIT:C125324, NCIT:C125292, NCIT:C125356, NCI:CTCAE, NCIT:C125411] synonym: "Frequency of Weight Loss" EXACT [NCIT:C125292] synonym: "Have weight loss" EXACT [NCIT:C125411] synonym: "How much distress weight loss" EXACT [NCIT:C125356] synonym: "How often weight loss" EXACT [NCIT:C125292] synonym: "Usual severity weight loss" EXACT [NCIT:C125324] synonym: "Weight decrease" EXACT [NCIT:C3445] synonym: "Weight loss adverse event" EXACT [NCIT:C55339] synonym: "Weight loss frequency" EXACT [NCIT:C125292] xref: UMLS:C0043096 xref: UMLS:C2911645 xref: NCI:CTCAE:10047900 xref: NCIT:C125292 xref: NCIT:C125324 xref: NCIT:C125356 xref: NCIT:C125411 xref: NCIT:C3445 xref: NCIT:C55339 property_value: ESCORT_rule "CCTO:000231 implies CCTO:000049" xsd:string ! ESCORT_rule ''Weight loss'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000231 implies CCTO:000051" xsd:string ! ESCORT_rule ''Weight loss'' implies ''Investigation'' is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000232 name: Time to event property_value: schema "duration_t CCTO:000232(time_t t0) = time_to_first_event(CCTO:000072, t0)" xsd:string ! schema duration_t ''Time to event''(time_t t0) = time_to_first_event(''Event'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000233 name: PSA progression free survival property_value: ESCORT_rule "CCTO:000233 = time-to-first CCTO:000103" xsd:string ! ESCORT_rule ''PSA progression free survival'' = time-to-first ''PSA progression'' property_value: schema "duration_t CCTO:000233(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000103) )" xsd:string ! schema duration_t ''PSA progression free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''PSA progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000234 name: Biochemical progression-free survival property_value: ESCORT_rule "CCTO:000234 = time-to-first CCTO:000235" xsd:string ! ESCORT_rule ''Biochemical progression-free survival'' = time-to-first ''Biochemical progression'' property_value: schema "duration_t CCTO:000234(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000235) )" xsd:string ! schema duration_t ''Biochemical progression-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Biochemical progression'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000235 name: Biochemical progression property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000236 name: Clinical complete response def: "The disappearance of all signs of cancer based on physical exam, such as palpation." [NCIT:C123574] synonym: "Clinical complete remission" EXACT [NCIT:C123574] synonym: "cCR" EXACT [NCIT:C123574] xref: UMLS:C1955905 xref: NCIT:C123574 property_value: schema "event_t CCTO:000236(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000236, t0, assessed_at)" xsd:string ! schema event_t ''Clinical complete response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Clinical complete response'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000237 name: Durable response property_value: ESCORT_rule "CCTO:000237 implies CCTO:000065" xsd:string ! ESCORT_rule ''Durable response'' implies ''Treatment response'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000237(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000237, t0, assessed_at)" xsd:string ! schema event_t ''Durable response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Durable response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000238 name: Durable response rate property_value: schema "probability_t CCTO:000238(time_t t0) = probability(CCTO:000237, t0)" xsd:string ! schema probability_t ''Durable response rate''(time_t t0) = probability(''Durable response'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000237 ! is_probability_of Durable response [Term] id: CCTO:000239 name: Circulating tumor cells def: "A metastatic cancer cell found in the peripheral blood OR The determination of the amount of circulating tumor cells present in a sample." [NCIT:C63797, NCIT:C96593] comment: circulating tumor cells synonym: "CTC" EXACT [NCIT:C63797] synonym: "CTC" EXACT [NCIT:C96593] synonym: "Circulating tumor cell count" EXACT [NCIT:C96593] synonym: "Circulating tumor cell" EXACT [NCIT:C63797] synonym: "Evidence of CTC" [] xref: UMLS:C0027625 xref: UMLS:C1516728 xref: UMLS:C3272887 xref: NCIT:C63797 xref: NCIT:C96593 property_value: ESCORT_rule "CCTO:000239 implies CCTO:000051" xsd:string ! ESCORT_rule ''Circulating tumor cells'' implies ''Investigation'' property_value: schema "event_t CCTO:000239(time_t t0) = EVENT_STATE(CCTO:000239, t0)" xsd:string ! schema event_t ''Circulating tumor cells''(time_t t0) = EVENT_STATE(''Circulating tumor cells'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000051 ! Investigation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000240 name: Time to distant metastasis property_value: ESCORT_rule "CCTO:000240 = time-to-first CCTO:000058" xsd:string ! ESCORT_rule ''Time to distant metastasis'' = time-to-first ''Has metastasis'' property_value: schema "duration_t CCTO:000240(time_t t0) = time_to_first_event(CCTO:000058, t0)" xsd:string ! schema duration_t ''Time to distant metastasis''(time_t t0) = time_to_first_event(''Has metastasis'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000241 name: Time to local progression property_value: ESCORT_rule "CCTO:000241 = time-to-first CCTO:000147" xsd:string ! ESCORT_rule ''Time to local progression'' = time-to-first ''Local progression'' property_value: schema "duration_t CCTO:000241(time_t t0) = time_to_first_event(CCTO:000147, t0)" xsd:string ! schema duration_t ''Time to local progression''(time_t t0) = time_to_first_event(''Local progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000242 name: Endometrial thickness property_value: ESCORT_rule "CCTO:000242 implies CCTO:000043" xsd:string ! ESCORT_rule ''Endometrial thickness'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000242 implies CCTO:000051" xsd:string ! ESCORT_rule ''Endometrial thickness'' implies ''Investigation'' property_value: schema "unknown_t CCTO:000242(time_t t0) = EVENT_STATE(CCTO:000242, t0)" xsd:string ! schema unknown_t ''Endometrial thickness''(time_t t0) = EVENT_STATE(''Endometrial thickness'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000051 ! Investigation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000243 name: Local relapse-free survival property_value: ESCORT_rule "CCTO:000243 = time-to-first CCTO:000114 CCTO:000244" xsd:string ! ESCORT_rule ''Local relapse-free survival'' = time-to-first ''Death'' ''Local relapse'' property_value: schema "duration_t CCTO:000243(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000244) )" xsd:string ! schema duration_t ''Local relapse-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Local relapse'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000244 name: Local relapse property_value: ESCORT_rule "CCTO:000244 implies CCTO:000056" xsd:string ! ESCORT_rule ''Local relapse'' implies ''Has local disease'' property_value: ESCORT_rule "CCTO:000244 implies CCTO:000081" xsd:string ! ESCORT_rule ''Local relapse'' implies ''Relapse'' property_value: ESCORT_rule "CCTO:000244 implies CCTO:000153" xsd:string ! ESCORT_rule ''Local relapse'' implies ''Local recurrence'' property_value: ESCORT_rule "CCTO:000244 implies NOT CCTO:000106" xsd:string ! ESCORT_rule ''Local relapse'' implies NOT ''Local control'' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000106 ! Local control relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000245 name: Dose-limiting toxicities synonym: "Dose limiting toxicity" [] property_value: schema "event_t CCTO:000245(time_t t0) = EVENT_STATE(CCTO:000245, t0)" xsd:string ! schema event_t ''Dose-limiting toxicities''(time_t t0) = EVENT_STATE(''Dose-limiting toxicities'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000246 name: Long term toxicity property_value: schema "event_t CCTO:000246(time_t t0) = EVENT_STATE(CCTO:000246, t0)" xsd:string ! schema event_t ''Long term toxicity''(time_t t0) = EVENT_STATE(''Long term toxicity'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000247 name: Perioperative morbidity property_value: ESCORT_rule "CCTO:000247 implies CCTO:000098" xsd:string ! ESCORT_rule ''Perioperative morbidity'' implies ''Treatment-related adverse events '' property_value: schema "event_t CCTO:000247(time_t t0) = EVENT_STATE(CCTO:000247, t0)" xsd:string ! schema event_t ''Perioperative morbidity''(time_t t0) = EVENT_STATE(''Perioperative morbidity'', t0) is_a: CCTO:000037 ! Measure of performance status is_a: CCTO:000098 ! Treatment-related adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000248 name: Hamilton depression scale property_value: ESCORT_rule "CCTO:000248 implies CCTO:000043" xsd:string ! ESCORT_rule ''Hamilton Depression Scale'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000248 implies CCTO:000118" xsd:string ! ESCORT_rule ''Hamilton Depression Scale'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000248(time_t t0) = EVENT_STATE(CCTO:000248, t0)" xsd:string ! schema event_t ''Hamilton Depression Scale''(time_t t0) = EVENT_STATE(''Hamilton Depression Scale'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000249 name: Mortality rate synonym: "Death rate" EXACT [NCIT:C53346] xref: UMLS:C0205848 xref: UMLS:C1108678 xref: UMLS:C0026565 xref: NCIT:C53346 xref: NCIT:C53358 property_value: schema "probability_t CCTO:000249(time_t t0) = probability(CCTO:000096, t0)" xsd:string ! schema probability_t ''Mortality rate''(time_t t0) = probability(''Mortality'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000096 ! is_probability_of Mortality [Term] id: CCTO:000250 name: Activities of daily living def: "Those physical activities which are required for our daily existence. These include personal maintenance activities and activities for maintenance of our living space, as well as activities related to independent living." [NCIT:C53291] synonym: "ADL" EXACT [NCIT:C53291] synonym: "Activity of Daily Living" EXACT [NCIT:C53291] synonym: "Daily activity" EXACT [NCIT:C53291] synonym: "Household activity" EXACT [NCIT:C53291] xref: UMLS:C0001288 xref: NCIT:C53291 property_value: schema "event_t CCTO:000250(time_t t0) = EVENT_STATE(CCTO:000250, t0)" xsd:string ! schema event_t ''Activities of daily living''(time_t t0) = EVENT_STATE(''Activities of daily living'', t0) is_a: CCTO:000037 ! Measure of performance status relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000251 name: Postoperative quality of life property_value: schema "event_t CCTO:000251(time_t t0) = EVENT_STATE(CCTO:000251, t0)" xsd:string ! schema event_t ''Postoperative quality of life''(time_t t0) = EVENT_STATE(''Postoperative quality of life'', t0) is_a: CCTO:000022 ! Quality of life is_a: CCTO:000023 ! Measure of quality of life relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000252 name: Initiation of Cytotoxic Chemotherapy property_value: ESCORT_rule "CCTO:000252 implies CCTO:000223" xsd:string ! ESCORT_rule ''Initiation of Cytotoxic Chemotherapy'' implies ''On treatment'' property_value: schema "event_t CCTO:000252(time_t t0) = EVENT_STATE(CCTO:000252, t0)" xsd:string ! schema event_t ''Initiation of Cytotoxic Chemotherapy''(time_t t0) = EVENT_STATE(''Initiation of Cytotoxic Chemotherapy'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000253 name: Time to Initiation of Cytotoxic Chemotherapy property_value: ESCORT_rule "CCTO:000253 = time-to-first CCTO:000252" xsd:string ! ESCORT_rule ''Time to Initiation of Cytotoxic Chemotherapy'' = time-to-first ''Initiation of Cytotoxic Chemotherapy'' property_value: schema "duration_t CCTO:000253(time_t t0) = time_to_first_event(CCTO:000252, t0)" xsd:string ! schema duration_t ''Time to Initiation of Cytotoxic Chemotherapy''(time_t t0) = time_to_first_event(''Initiation of Cytotoxic Chemotherapy'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000254 name: Intraoperative blood loss property_value: ESCORT_rule "CCTO:000254 implies CCTO:000098" xsd:string ! ESCORT_rule ''Intraoperative blood loss'' implies ''Treatment-related adverse events '' property_value: schema "event_t CCTO:000254(time_t t0) = EVENT_STATE(CCTO:000254, t0)" xsd:string ! schema event_t ''Intraoperative blood loss''(time_t t0) = EVENT_STATE(''Intraoperative blood loss'', t0) is_a: CCTO:000098 ! Treatment-related adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000255 name: Locoregional control rate synonym: "Local-regional control rate" [] property_value: schema "probability_t CCTO:000255(time_t t0) = probability(CCTO:000171, t0)" xsd:string ! schema probability_t ''Locoregional control rate''(time_t t0) = probability(''Local-regional control'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000171 ! is_probability_of Local-regional control [Term] id: CCTO:000256 name: Hematologic improvement def: "An evaluation of the hematologic response of the disease to the therapy." [NCIT:C123622] synonym: "HEMARESP" EXACT [NCIT:C123622] synonym: "Hematologic response" EXACT [NCIT:C123622] xref: NCIT:C123622 property_value: ESCORT_rule "CCTO:000256 implies NOT CCTO:000341" xsd:string ! ESCORT_rule ''Hematologic improvement'' implies NOT ''Hematologic toxicity'' property_value: schema "event_t CCTO:000256(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000256, t0, assessed_at)" xsd:string ! schema event_t ''Hematologic improvement''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Hematologic improvement'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000341 ! Hematologic toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000257 name: Pain relief def: "A lessening of pain following an intervention." [NCIT:C112216] xref: UMLS:C0451615 xref: NCIT:C112216 property_value: ESCORT_rule "CCTO:000257 implies CCTO:000043" xsd:string ! ESCORT_rule ''Pain relief'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000257 implies CCTO:000178" xsd:string ! ESCORT_rule ''Pain relief'' implies ''Pain response'' property_value: ESCORT_rule "CCTO:000257 implies NOT CCTO:000130" xsd:string ! ESCORT_rule ''Pain relief'' implies NOT ''Pain progression'' property_value: schema "unknown_t NULL" xsd:string ! schema is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety disjoint_from: CCTO:000130 ! Pain progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000258 name: Relapse-free survival rate property_value: schema "probability_t CCTO:000258(time_t t0, time_t assessed_at) = probability(CCTO:000080(t0), assessed_at)" xsd:string ! schema probability_t ''Relapse-free survival rate''(time_t t0, time_t assessed_at) = probability(''Relapse-free survival''(t0), assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000011 CCTO:000080 ! is_timed_observation_of Relapse-free survival [Term] id: CCTO:000259 name: Cognitive function def: "The collection of PROMIS item scales that assess perceived difficulties in intellectual processes, capabilities, and deficits." [NCIT:C122365] synonym: "Cognitive Function Item Bank" EXACT [NCIT:C122365] synonym: "Cognitive function subordinate domain" EXACT [NCIT:C122365] xref: UMLS:C0392335 xref: NCIT:C122365 property_value: ESCORT_rule "CCTO:000259 implies CCTO:000018" xsd:string ! ESCORT_rule ''Cognitive function'' implies ''Neurocognitive function'' property_value: schema "event_t CCTO:000259(time_t t0) = EVENT_STATE(CCTO:000259, t0)" xsd:string ! schema event_t ''Cognitive function''(time_t t0) = EVENT_STATE(''Cognitive function'', t0) is_a: CCTO:000018 ! Neurocognitive function is_a: CCTO:000020 ! Measure of neurocognitive function relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000260 name: Anxiety def: "Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus OR A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus." [NCIT:C26696, NCI:CTCAE] xref: UMLS:C0003467 xref: UMLS:C1963064 xref: NCI:CTCAE:10002855 xref: NCIT:C26696 property_value: ESCORT_rule "CCTO:000260 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anxiety'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000260 implies CCTO:001105" xsd:string ! ESCORT_rule ''Anxiety'' implies ''Psychiatric disorders'' is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000180 ! is_assessed_by Hospital Anxiety and Depression Scale relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000261 name: Patient-reported quality of life property_value: ESCORT_rule "CCTO:000261 implies CCTO:000118" xsd:string ! ESCORT_rule ''Patient-reported quality of life'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000261(time_t t0) = EVENT_STATE(CCTO:000261, t0)" xsd:string ! schema event_t ''Patient-reported quality of life''(time_t t0) = EVENT_STATE(''Patient-reported quality of life'', t0) is_a: CCTO:000023 ! Measure of quality of life is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000262 name: Residual erectile function property_value: ESCORT_rule "CCTO:000262 implies CCTO:000049" xsd:string ! ESCORT_rule ''Residual erectile function'' implies ''Adverse events'' property_value: schema "event_t CCTO:000262(time_t t0) = EVENT_STATE(CCTO:000262, t0)" xsd:string ! schema event_t ''Residual erectile function''(time_t t0) = EVENT_STATE(''Residual erectile function'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000263 name: Expanded Prostate Cancer Index Composite def: "A self-administered questionnaire designed to evaluate patient function and bother after prostate cancer treatment." [NCIT:C107630] comment: EPIC synonym: "EPIC" EXACT [NCIT:C107630] synonym: "Expanded Prostate Cancer Index Composite (EPIC)" EXACT [NCIT:C107630] xref: UMLS:C1273342 xref: UMLS:C3810536 xref: UMLS:C3810535 xref: NCIT:C107630 property_value: ESCORT_rule "CCTO:000263 implies CCTO:000118" xsd:string ! ESCORT_rule ''Expanded Prostate Cancer Index Composite'' implies ''Patient reported outcomes'' property_value: schema "unknown_t CCTO:000263(time_t t0) = EVENT_STATE(CCTO:000263, t0)" xsd:string ! schema unknown_t ''Expanded Prostate Cancer Index Composite''(time_t t0) = EVENT_STATE(''Expanded Prostate Cancer Index Composite'', t0) is_a: CCTO:000023 ! Measure of quality of life is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000264 name: Hypopigmentation def: "A disorder characterized by loss of skin pigment OR Abnormal lightening of skin due to decreased melanin production or deposition. Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation." [NCI:CTCAE, NCIT:C78610] synonym: "Pigment dilution" EXACT [NCIT:C78610] synonym: "Skin hypopigmentation" EXACT [NCIT:C78610] xref: UMLS:C0162835 xref: UMLS:C1963139 xref: UMLS:C1876214 xref: NCI:CTCAE:10040868 xref: NCIT:C78610 property_value: ESCORT_rule "CCTO:000264 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypopigmentation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000264 implies CCTO:001128" xsd:string ! ESCORT_rule ''Hypopigmentation'' implies ''Skin and subcutaneous tissue disorders'' property_value: ESCORT_rule "CCTO:000264 implies NOT CCTO:000267" xsd:string ! ESCORT_rule ''Hypopigmentation'' implies NOT ''Hyperpigmentation'' property_value: schema "CCTO:000264(time_t t0) = EVENT_STATE(CCTO:000264, t0)" xsd:string ! schema ''Hypopigmentation''(time_t t0) = EVENT_STATE(''Hypopigmentation'', t0) property_value: schema "event_t CCTO:000264(time_t t0) = EVENT_STATE(CCTO:000264, t0)" xsd:string ! schema event_t ''Hypopigmentation''(time_t t0) = EVENT_STATE(''Hypopigmentation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders disjoint_from: CCTO:000267 ! Hyperpigmentation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000265 name: Biochemical response property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000265(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000265, t0, assessed_at)" xsd:string ! schema event_t ''Biochemical response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Biochemical response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000266 name: Symptoms improvement synonym: "Symptom improvement" [] property_value: ESCORT_rule "CCTO:000266 implies NOT CCTO:000181" xsd:string ! ESCORT_rule ''Symptoms improvement'' implies NOT ''Symptomatic progression'' property_value: schema "event_t CCTO:000266(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000266, t0, assessed_at)" xsd:string ! schema event_t ''Symptoms improvement''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Symptoms improvement'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000181 ! Symptomatic progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000267 name: Hyperpigmentation def: "A disorder characterized by darkening of the skin due to excessive melanin deposition OR Darkening of the skin due to excessive melanin deposition. Causes include skin injuries, pregnancy, eczema, and Addison disease." [NCI:CTCAE, NCIT:C79731] synonym: "Skin hyperpigmentation" EXACT [NCIT:C79731] xref: UMLS:C0162834 xref: UMLS:C1962962 xref: NCI:CTCAE:10040865 xref: NCIT:C79731 property_value: ESCORT_rule "CCTO:000267 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperpigmentation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000267 implies CCTO:001128" xsd:string ! ESCORT_rule ''Hyperpigmentation'' implies ''Skin and subcutaneous tissue disorders'' property_value: ESCORT_rule "CCTO:000267 implies NOT CCTO:000264" xsd:string ! ESCORT_rule ''Hyperpigmentation'' implies NOT ''Hypopigmentation'' property_value: schema "CCTO:000267(time_t t0) = EVENT_STATE(CCTO:000267, t0)" xsd:string ! schema ''Hyperpigmentation''(time_t t0) = EVENT_STATE(''Hyperpigmentation'', t0) property_value: schema "event_t CCTO:000267(time_t t0) = EVENT_STATE(CCTO:000267, t0)" xsd:string ! schema event_t ''Hyperpigmentation''(time_t t0) = EVENT_STATE(''Hyperpigmentation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders disjoint_from: CCTO:000264 ! Hypopigmentation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000268 name: Modified ASEPSIS Scale property_value: ESCORT_rule "CCTO:000268 implies CCTO:000043" xsd:string ! ESCORT_rule ''Modified ASEPSIS Scale'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000268(time_t t0) = EVENT_STATE(CCTO:000268, t0)" xsd:string ! schema event_t ''Modified ASEPSIS Scale''(time_t t0) = EVENT_STATE(''Modified ASEPSIS Scale'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000053 ! Clinical criteria relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000269 name: Surgical site infection score property_value: ESCORT_rule "CCTO:000269 implies CCTO:000043" xsd:string ! ESCORT_rule ''Surgical Site Infection Score'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000269(time_t t0) = EVENT_STATE(CCTO:000269, t0)" xsd:string ! schema event_t ''Surgical Site Infection Score''(time_t t0) = EVENT_STATE(''Surgical Site Infection Score'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000053 ! Clinical criteria relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000268 ! is_assessed_by Modified ASEPSIS Scale [Term] id: CCTO:000270 name: Symptomatic skeletal event def: "Symptomatic fracture, surgery or radiation to bone, or spinal cord compression" [JClinOncol32:5s,2014(suppl;abstr5075)] property_value: ESCORT_rule "CCTO:000270 implies CCTO:000166" xsd:string ! ESCORT_rule ''Symptomatic skeletal event'' implies ''Skeletal-related event'' property_value: schema "event_t CCTO:000270(time_t t0) = EVENT_STATE(CCTO:000270, t0)" xsd:string ! schema event_t ''Symptomatic skeletal event''(time_t t0) = EVENT_STATE(''Symptomatic skeletal event'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000166 ! Skeletal-related event relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000271 name: Time to first symptomatic skeletal event property_value: schema "duration_t CCTO:000271(time_t t0) = time_to_first_event(CCTO:000270, t0)" xsd:string ! schema duration_t ''Time to first symptomatic skeletal event''(time_t t0) = time_to_first_event(''Symptomatic skeletal event'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000272 name: Flatus def: "Gas or air in the gastrointestinal tract." [NCIT:C50569] xref: UMLS:C0016204 xref: NCIT:C50569 property_value: ESCORT_rule "CCTO:000272 implies CCTO:000043" xsd:string ! ESCORT_rule ''Flatus'' implies ''Measure of safety'' property_value: schema "event_t CCTO:000272(time_t t0) = EVENT_STATE(CCTO:000272, t0)" xsd:string ! schema event_t ''Flatus''(time_t t0) = EVENT_STATE(''Flatus'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000273 name: Time to first flatus property_value: ESCORT_rule "CCTO:000273 = time-to-first CCTO:000272" xsd:string ! ESCORT_rule ''Time to first flatus'' = time-to-first ''Flatus'' property_value: schema "duration_t CCTO:000273(time_t t0) = time_to_first_event(CCTO:000272, t0)" xsd:string ! schema duration_t ''Time to first flatus''(time_t t0) = time_to_first_event(''Flatus'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000274 name: Local skin reactions property_value: ESCORT_rule "CCTO:000274 implies CCTO:000049" xsd:string ! ESCORT_rule ''Local skin reactions'' implies ''Adverse events'' property_value: schema "unknown_t CCTO:000274(time_t t0) = EVENT_STATE(CCTO:000274, t0)" xsd:string ! schema unknown_t ''Local skin reactions''(time_t t0) = EVENT_STATE(''Local skin reactions'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000275 name: Distant recurrence-free survival property_value: ESCORT_rule "CCTO:000275 = time-to-first CCTO:000114 CCTO:000215" xsd:string ! ESCORT_rule ''Distant recurrence-free survival'' = time-to-first ''Death'' ''Distant recurrence'' property_value: schema "duration_t CCTO:000275(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000215) )" xsd:string ! schema duration_t ''Distant recurrence-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Distant recurrence'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000276 name: Cardiac toxicity def: "Toxicity that impairs or damages the heart. This condition is often caused by the administration of a pharmaceutical agent that initiates a poisonous or toxic response in cardiac tissue." [NCIT:C27994] synonym: "Cardiotoxicity" EXACT [NCIT:C27994] synonym: "Toxicity, cardiac" EXACT [NCIT:C27994] xref: UMLS:C0876994 xref: NCIT:C27994 property_value: schema "event_t CCTO:000276(time_t t0) = EVENT_STATE(CCTO:000276, t0)" xsd:string ! schema event_t ''Cardiac toxicity''(time_t t0) = EVENT_STATE(''Cardiac toxicity'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000277 name: Clinical tumor regression property_value: schema "event_t CCTO:000277(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000277, t0, assessed_at)" xsd:string ! schema event_t ''Clinical tumor regression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Clinical tumor regression'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000278 name: Lymph node response synonym: "Nodal response" [] property_value: schema "event_t CCTO:000278(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000278, t0, assessed_at)" xsd:string ! schema event_t ''Lymph node response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Lymph node response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000279 name: Lymph node response rate synonym: "Nodal response rate" [] property_value: schema "probability_t CCTO:000279(time_t t0, time_t assessed_at) = probability(CCTO:000278(t0, assessed_at) == TRUE, assessed_at)" xsd:string ! schema probability_t ''Lymph node response rate''(time_t t0, time_t assessed_at) = probability(''Lymph node response''(t0, assessed_at) == TRUE, assessed_at) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability [Term] id: CCTO:000280 name: Postoperative mortality property_value: ESCORT_rule "CCTO:000280 implies CCTO:000090" xsd:string ! ESCORT_rule ''Postoperative mortality'' implies ''Treatment-related mortality'' property_value: ESCORT_rule "CCTO:000280 implies CCTO:000179" xsd:string ! ESCORT_rule ''Postoperative mortality'' implies ''Surgical complications'' property_value: schema "event_t CCTO:000280(time_t t0) = EVENT_STATE(CCTO:000280, t0)" xsd:string ! schema event_t ''Postoperative mortality''(time_t t0) = EVENT_STATE(''Postoperative mortality'', t0) is_a: CCTO:000090 ! Treatment-related mortality relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000281 name: Sphincter preservation property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000281(time_t t0) = EVENT_STATE(CCTO:000281, t0)" xsd:string ! schema event_t ''Sphincter preservation''(time_t t0) = EVENT_STATE(''Sphincter preservation'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000282 name: Sphincter preservation rate property_value: schema "probability_t CCTO:000282(time_t t0) = probability(CCTO:000281, t0)" xsd:string ! schema probability_t ''Sphincter preservation rate''(time_t t0) = probability(''Sphincter preservation'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000281 ! is_probability_of Sphincter preservation [Term] id: CCTO:000283 name: Time to distant failure property_value: ESCORT_rule "CCTO:000283 = time-to-first CCTO:000190 " xsd:string ! ESCORT_rule ''Time to distant failure'' = time-to-first ''Distant failure'' property_value: schema "duration_t CCTO:000283(time_t t0) = time_to_first_event(CCTO:000190, t0)" xsd:string ! schema duration_t ''Time to distant failure''(time_t t0) = time_to_first_event(''Distant failure'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000284 name: Treatment completion synonym: "Completion" [] property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000284(time_t t0) = EVENT_STATE(CCTO:000284, t0)" xsd:string ! schema event_t ''Treatment completion''(time_t t0) = EVENT_STATE(''Treatment completion'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000045 ! Measure of adherence xref: UMLS:C1554962 xref: UMLS:C0580352 xref: UMLS:C0205197 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000285 name: Treatment completion rate synonym: "Completion rate" [] property_value: schema "probability_t CCTO:000285(time_t t0) = probability(CCTO:000284, t0)" xsd:string ! schema probability_t ''Treatment completion rate''(time_t t0) = probability(''Treatment completion'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000045 ! Measure of adherence relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000284 ! is_probability_of Treatment completion [Term] id: CCTO:000286 name: Analgesic consumption synonym: "Analgesic use" [] property_value: schema "event_t CCTO:000286(time_t t0) = EVENT_STATE(CCTO:000286, t0)" xsd:string ! schema event_t ''Analgesic consumption''(time_t t0) = EVENT_STATE(''Analgesic consumption'', t0) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000287 name: Bleeding def: "The flow of blood from a ruptured blood vessel." [NCIT:C26791] synonym: "Haemorrhage" [] synonym: "Hemorrhage" EXACT [NCIT:C26791] xref: UMLS:C0019080 xref: NCIT:C26791 property_value: ESCORT_rule "CCTO:000287 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bleeding'' implies ''Adverse events'' property_value: schema "unknown_t CCTO:000287(time_t t0) = EVENT_STATE(CCTO:000287, t0)" xsd:string ! schema unknown_t ''Bleeding''(time_t t0) = EVENT_STATE(''Bleeding'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000288 name: Muscle strength property_value: ESCORT_rule "CCTO:000288 implies CCTO:000043" xsd:string ! ESCORT_rule ''Muscle strength'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000288 implies CCTO:000051" xsd:string ! ESCORT_rule ''Muscle strength'' implies ''Investigation'' property_value: schema "unknown_t CCTO:000288(time_t t0) = EVENT_STATE(CCTO:000288, t0)" xsd:string ! schema unknown_t ''Muscle strength''(time_t t0) = EVENT_STATE(''Muscle strength'', t0) is_a: CCTO:000033 ! Measure of nutritional status is_a: CCTO:000037 ! Measure of performance status is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000051 ! Investigation xref: UMLS:C0517349 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000289 name: Radiographic response rate property_value: schema "probability_t CCTO:000289(time_t t0) = probability(CCTO:000159, t0)" xsd:string ! schema probability_t ''Radiographic response rate''(time_t t0) = probability(''Radiographic response'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000159 ! is_probability_of Radiographic response [Term] id: CCTO:000290 name: Breast cancer-free property_value: ESCORT_rule "CCTO:000290 implies NOT CCTO:000291" xsd:string ! ESCORT_rule ''Breast cancer-free'' implies NOT ''Breast cancer'' property_value: ESCORT_rule "NOT CCTO:000290 implies CCTO:000291" xsd:string ! ESCORT_rule NOT ''Breast cancer-free'' implies ''Breast cancer'' property_value: schema "event_t CCTO:000290(time_t t0) = NOT EVENT_STATE(CCTO:000291, t0)" xsd:string ! schema event_t ''Breast cancer-free''(time_t t0) = NOT EVENT_STATE(''Breast cancer'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000291 ! Breast cancer relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000291 ! is_opposite_of Breast cancer [Term] id: CCTO:000291 name: Breast cancer def: "A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla." [NCIT:C4872] synonym: "Breast carcinoma" EXACT [NCIT:C4872] synonym: "Breast cancer, NOS" EXACT [NCIT:C4872] synonym: "Cancer of Breast" EXACT [NCIT:C4872] synonym: "Cancer of the Breast" EXACT [NCIT:C4872] synonym: "Cancer, breast" EXACT [NCIT:C4872] synonym: "Carcinoma of Breast" EXACT [NCIT:C4872] synonym: "Carcinoma of the Breast" EXACT [NCIT:C4872] synonym: "Mammary carcinoma" EXACT [NCIT:C4872] xref: UMLS:C0678222 xref: UMLS:C0006142 xref: NCIT:C4872 property_value: ESCORT_rule "CCTO:000291 implies CCTO:000070" xsd:string ! ESCORT_rule ''Breast cancer'' implies ''Has disease'' property_value: ESCORT_rule "CCTO:000291 implies NOT CCTO:000290" xsd:string ! ESCORT_rule ''Breast cancer'' implies NOT ''Breast cancer-free'' property_value: ESCORT_rule "NOT CCTO:000291 implies CCTO:000290" xsd:string ! ESCORT_rule NOT ''Breast cancer'' implies ''Breast cancer-free'' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000290 ! Breast cancer-free relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000010 CCTO:000290 ! is_opposite_of Breast cancer-free [Term] id: CCTO:000292 name: Breast cancer-free interval property_value: schema "duration_t CCTO:000292(time_t t0) = time_to_first_event(CCTO:000291, t0)" xsd:string ! schema duration_t ''Breast cancer-free interval''(time_t t0) = time_to_first_event(''Breast cancer'', t0) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000293 name: Time to distant recurrence property_value: ESCORT_rule "CCTO:000293 = time-to-first CCTO:000215 " xsd:string ! ESCORT_rule ''Time to distant recurrence'' = time-to-first ''Distant recurrence'' property_value: schema "duration_t CCTO:000293(time_t t0) = time_to_first_event(CCTO:000215, t0)" xsd:string ! schema duration_t ''Time to distant recurrence''(time_t t0) = time_to_first_event(''Distant recurrence'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000294 name: Length of postoperative hospital stay property_value: schema "duration_t CCTO:000294(time_t t0) = duration_of_event(CCTO:000321, t0)" xsd:string ! schema duration_t ''Length of postoperative hospital stay''(time_t t0) = duration_of_event(''Postoperative hospital stay'', t0) is_a: CCTO:000113 ! Length of hospital stay relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration relationship: CCTO:000012 CCTO:000321 ! is_duration_of Postoperative hospital stay [Term] id: CCTO:000295 name: Biochemical control property_value: ESCORT_rule "CCTO:000295 implies NOT CCTO:000299" xsd:string ! ESCORT_rule ''Biochemical control'' implies NOT ''Biochemical relapse'' property_value: ESCORT_rule "CCTO:000295 implies NOT CCTO:001107" xsd:string ! ESCORT_rule ''Biochemical control'' implies NOT ''Tumor marker increased'' property_value: schema "event_t CCTO:000295(time_t t0) = EVENT_STATE(CCTO:000295, t0)" xsd:string ! schema event_t ''Biochemical control''(time_t t0) = EVENT_STATE(''Biochemical control'', t0) is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000299 ! Biochemical relapse disjoint_from: CCTO:001107 ! Tumor marker increased relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000296 name: Serum PSA property_value: ESCORT_rule "CCTO:000296 implies CCTO:000051" xsd:string ! ESCORT_rule ''Serum PSA'' implies ''Investigation'' property_value: schema "unknown_t CCTO:000296(time_t t0) = EVENT_STATE(CCTO:000296, t0)" xsd:string ! schema unknown_t ''Serum PSA''(time_t t0) = EVENT_STATE(''Serum PSA'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000051 ! Investigation relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000297 name: Physical function def: "The collection of PROMIS item scales that assess an individual's ability to carry out activities that require physical actions including more complex activities that require a combination of skills, often within a social context." [NCIT:C122356] synonym: "Physical Function Item Bank" EXACT [NCIT:C122356] synonym: "Physical function subordinate domain" EXACT [NCIT:C122356] xref: UMLS:C0516981 xref: NCIT:C122356 property_value: schema "event_t CCTO:000297(time_t t0) = EVENT_STATE(CCTO:000297, t0)" xsd:string ! schema event_t ''Physical Function''(time_t t0) = EVENT_STATE(''Physical Function'', t0) is_a: CCTO:000037 ! Measure of performance status relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000298 name: Biochemical relapse-free survival property_value: ESCORT_rule "CCTO:000298 = time-to-first CCTO:000114 CCTO:000299" xsd:string ! ESCORT_rule ''Biochemical relapse-free survival'' = time-to-first ''Death'' ''Biochemical relapse'' property_value: schema "duration_t CCTO:000298(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000299) )" xsd:string ! schema duration_t ''Biochemical relapse-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Biochemical relapse'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000299 name: Biochemical relapse synonym: "PSA Failure" EXACT [NCIT:C93229] synonym: "PSA failure" EXACT [NCIT:C93229] synonym: "biochemical recurrence" EXACT [NCIT:C93229] xref: UMLS:C2985506 xref: NCIT:C93229 property_value: ESCORT_rule "CCTO:000299 implies CCTO:001107" xsd:string ! ESCORT_rule ''Biochemical relapse'' implies ''Tumor marker increased'' property_value: ESCORT_rule "CCTO:000299 implies NOT CCTO:000295" xsd:string ! ESCORT_rule ''Biochemical relapse'' implies NOT ''Biochemical control'' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:000295 ! Biochemical control relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000300 name: PSA doubling time property_value: schema "duration_t CCTO:000300(time_t t0) = EVENT_STATE(CCTO:000300, t0)" xsd:string ! schema duration_t ''PSA doubling time''(time_t t0) = EVENT_STATE(''PSA doubling time'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000051 ! Investigation relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000301 name: Regional recurrence free survival property_value: ESCORT_rule "CCTO:000301 = time-to-first CCTO:000114 CCTO:001104" xsd:string ! ESCORT_rule ''Regional recurrence free survival'' = time-to-first ''Death'' ''Regional recurrence'' property_value: schema "duration_t CCTO:000301(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:001104) )" xsd:string ! schema duration_t ''Regional recurrence free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Regional recurrence'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000302 name: ECOG performance status def: "A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient." [NCIT:C105721] synonym: "ECOG Score" EXACT [NCIT:C105721] synonym: "Eastern Cooperative Oncology Group Performance Status" EXACT [NCIT:C105721] xref: UMLS:C3714786 xref: UMLS:C1520224 xref: NCIT:C105721 property_value: schema "event_t CCTO:000302(time_t t0) = EVENT_STATE(CCTO:000302, t0)" xsd:string ! schema event_t ''ECOG performance status''(time_t t0) = EVENT_STATE(''ECOG performance status'', t0) is_a: CCTO:000037 ! Measure of performance status is_a: CCTO:000053 ! Clinical criteria relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000303 name: Biochemical response rate property_value: schema "probability_t CCTO:000303(time_t t0) = probability(CCTO:000265, t0)" xsd:string ! schema probability_t ''Biochemical response rate''(time_t t0) = probability(''Biochemical response'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000265 ! is_probability_of Biochemical response [Term] id: CCTO:000304 name: Quality adjusted life years def: "A measure of the health of a population that combines an assessment of both mortality and disability. (Taber's)" [NCIT:C21095] synonym: "QALY" EXACT [NCIT:C21095] xref: UMLS:C0080071 xref: NCIT:C21095 property_value: schema "unknown_t CCTO:000304(time_t t0) = EVENT_STATE(CCTO:000304, t0)" xsd:string ! schema unknown_t ''Quality adjusted life years''(time_t t0) = EVENT_STATE(''Quality adjusted life years'', t0) is_a: CCTO:000023 ! Measure of quality of life relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000305 name: Injection site reaction def: "An intense reaction (usually immunologic) developing at the site of injection OR A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection." [NCIT:C3508, NCI:CTCAE] synonym: "Reaction, injection site" EXACT [NCIT:C3508] xref: UMLS:C0151735 xref: NCI:CTCAE:10022095 xref: NCIT:C3508 property_value: ESCORT_rule "CCTO:000305 implies CCTO:000098" xsd:string ! ESCORT_rule ''Injection site reaction'' implies ''Treatment-related adverse events '' property_value: ESCORT_rule "CCTO:000305 implies CCTO:001103" xsd:string ! ESCORT_rule ''Injection site reaction'' implies ''General disorders and administration site conditions'' is_a: CCTO:000098 ! Treatment-related adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000306 name: Subject Satisfaction Score property_value: ESCORT_rule "CCTO:000306 implies CCTO:000118" xsd:string ! ESCORT_rule ''Subject Satisfaction Score'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000306(time_t t0) = EVENT_STATE(CCTO:000306, t0)" xsd:string ! schema event_t ''Subject Satisfaction Score''(time_t t0) = EVENT_STATE(''Subject Satisfaction Score'', t0) is_a: CCTO:000026 ! Measure of patient satisfaction is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000307 name: Brief Fatigue Inventory def: "A 9-item questionnaire, developed by Cleeland and Mendoza, designed to assess the severity of fatigue and the impact of fatigue on daily functioning in cancer patients." [NCIT:C74297] synonym: "BFI" EXACT [NCIT:C74297] xref: UMLS:C2698562 xref: NCIT:C74297 property_value: ESCORT_rule "CCTO:000307 implies CCTO:000043" xsd:string ! ESCORT_rule ''Brief Fatigue Inventory'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000307 implies CCTO:000118" xsd:string ! ESCORT_rule ''Brief Fatigue Inventory'' implies ''Patient reported outcomes'' property_value: schema "event_t CCTO:000307(time_t t0) = EVENT_STATE(CCTO:000307, t0)" xsd:string ! schema event_t ''Brief Fatigue Inventory''(time_t t0) = EVENT_STATE(''Brief Fatigue Inventory'', t0) is_a: CCTO:000043 ! Measure of safety is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000308 name: Sexuality problems property_value: ESCORT_rule "CCTO:000308 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sexuality problems'' implies ''Adverse events'' property_value: schema "event_t CCTO:000308(time_t t0) = EVENT_STATE(CCTO:000308, t0)" xsd:string ! schema event_t ''Sexuality problems''(time_t t0) = EVENT_STATE(''Sexuality problems'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000309 name: Readmission property_value: ESCORT_rule "CCTO:000309 implies CCTO:000049" xsd:string ! ESCORT_rule ''Readmission'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000309 implies CCTO:000150" xsd:string ! ESCORT_rule ''Readmission'' implies ''Hospital stay'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000309(time_t t0) = EVENT_STATE(CCTO:000309, t0)" xsd:string ! schema event_t ''Readmission''(time_t t0) = EVENT_STATE(''Readmission'', t0) is_a: CCTO:000035 ! Measure of healthcare resource utilization is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000310 name: Readmission rate property_value: schema "probability_t CCTO:000310(time_t t0) = probability(CCTO:000309, t0)" xsd:string ! schema probability_t ''Readmission rate''(time_t t0) = probability(''Readmission'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000035 ! Measure of healthcare resource utilization relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000309 ! is_probability_of Readmission [Term] id: CCTO:000311 name: Intimacy problems property_value: ESCORT_rule "CCTO:000311 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intimacy problems'' implies ''Adverse events'' property_value: schema "event_t CCTO:000311(time_t t0) = EVENT_STATE(CCTO:000311, t0)" xsd:string ! schema event_t ''Intimacy problems''(time_t t0) = EVENT_STATE(''Intimacy problems'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000312 name: Adherence rate property_value: schema "probability_t CCTO:000312(time_t t0) = probability(CCTO:000044, t0)" xsd:string ! schema probability_t ''Adherence rate''(time_t t0) = probability(''Adherence'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000045 ! Measure of adherence relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000044 ! is_probability_of Adherence [Term] id: CCTO:000313 name: Erectile function property_value: ESCORT_rule "CCTO:000313 implies CCTO:000049" xsd:string ! ESCORT_rule ''Erectile function'' implies ''Adverse events'' property_value: schema "event_t CCTO:000313(time_t t0) = EVENT_STATE(CCTO:000313, t0)" xsd:string ! schema event_t ''Erectile function''(time_t t0) = EVENT_STATE(''Erectile function'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000314 name: Adverse event rate synonym: "Adverse events rate" [] property_value: schema "probability_t CCTO:000314(time_t t0) = probability(CCTO:000049, t0)" xsd:string ! schema probability_t ''Adverse event rate''(time_t t0) = probability(''Adverse events'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000049 ! is_probability_of Adverse events [Term] id: CCTO:000315 name: Symptomatic skeletal event free survival comment: SSE-FS property_value: ESCORT_rule "CCTO:000315 = time-to-first CCTO:000114 CCTO:000270" xsd:string ! ESCORT_rule ''Symptomatic skeletal event free survival'' = time-to-first ''Death'' ''Symptomatic skeletal event'' property_value: schema "duration_t CCTO:000315(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000270) )" xsd:string ! schema duration_t ''Symptomatic skeletal event free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Symptomatic skeletal event'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000316 name: Biochemical disease-free survival property_value: schema "duration_t CCTO:000316(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:001107) )" xsd:string ! schema duration_t ''Biochemical disease-free survival''(time_t t0) = min( time_to_first_event(t0, ''Death''), time_to_first_event(t0, ''Tumor marker increased'') ) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000317 name: Local failure property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000317(time_t t0) = EVENT_STATE(CCTO:000317, t0)" xsd:string ! schema event_t ''Local failure''(time_t t0) = EVENT_STATE(''Local failure'', t0) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000318 name: Local failure rate property_value: schema "probability_t CCTO:000318(time_t t0) = probability(CCTO:000317, t0)" xsd:string ! schema probability_t ''Local failure rate''(time_t t0) = probability(''Local failure'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000317 ! is_probability_of Local failure [Term] id: CCTO:000319 name: Neurotoxicity def: "A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives." [NCIT:C27961] synonym: "Neurotoxicity syndrome" EXACT [NCIT:C27961] xref: UMLS:C0235032 xref: NCIT:C27961 property_value: schema "event_t CCTO:000319(time_t t0) = EVENT_STATE(CCTO:000319, t0)" xsd:string ! schema event_t ''Neurotoxicity''(time_t t0) = EVENT_STATE(''Neurotoxicity'', t0) is_a: CCTO:000048 ! Toxicity relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000320 name: Infectious complications property_value: ESCORT_rule "CCTO:000320 implies CCTO:000049" xsd:string ! ESCORT_rule ''Infectious complications'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000320 implies CCTO:000129" xsd:string ! ESCORT_rule ''Infectious complications'' implies ''Infections'' property_value: schema "event_t CCTO:000320(time_t t0) = EVENT_STATE(CCTO:000320, t0)" xsd:string ! schema event_t ''Infectious complications''(time_t t0) = EVENT_STATE(''Infectious complications'', t0) is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000321 name: Postoperative hospital stay property_value: has_operator CCTO:000012 ! has_operator is_duration_of property_value: schema "unknown_t CCTO:000321(time_t t0) = EVENT_STATE(CCTO:000321, t0)" xsd:string ! schema unknown_t ''Postoperative hospital stay''(time_t t0) = EVENT_STATE(''Postoperative hospital stay'', t0) is_a: CCTO:000294 ! Length of postoperative hospital stay relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000322 name: Surgical site infection def: "An infection that occurs at a surgical site within 30 days after an operation." [NCIT:C112019] xref: UMLS:C2316459 xref: NCIT:C112019 property_value: ESCORT_rule "CCTO:000322 implies CCTO:000098" xsd:string ! ESCORT_rule ''Surgical site infection'' implies ''Treatment-related adverse events '' property_value: schema "unknown_t CCTO:000322(time_t t0) = EVENT_STATE(CCTO:000322, t0)" xsd:string ! schema unknown_t ''Surgical site infection''(time_t t0) = EVENT_STATE(''Surgical site infection'', t0) is_a: CCTO:000098 ! Treatment-related adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000323 name: Time to local failure property_value: schema "duration_t CCTO:000323(time_t t0) = time_to_first_event(CCTO:000317, t0)" xsd:string ! schema duration_t ''Time to local failure''(time_t t0) = time_to_first_event(''Local failure'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000324 name: Nausea and vomiting def: "Expelling the contents of the stomach and the sensations associated with it. They are symptoms of an underlying disease or condition and not a specific illness." [NCIT:C3259] synonym: "Vomiting and Nausea" EXACT [NCIT:C3259] xref: UMLS:C0027498 xref: NCIT:C3259 property_value: ESCORT_rule "CCTO:000324 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nausea and vomiting'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000324 is-union-of CCTO:000333 CCTO:000554" xsd:string ! ESCORT_rule ''Nausea and vomiting'' is-union-of ''Nausea'' ''Vomiting'' property_value: ESCORT_rule "CCTO:000333 implies CCTO:000324" xsd:string ! ESCORT_rule ''Nausea'' implies ''Nausea and vomiting'' property_value: ESCORT_rule "CCTO:000554 implies CCTO:000324" xsd:string ! ESCORT_rule ''Vomiting'' implies ''Nausea and vomiting'' property_value: schema "unknown_t CCTO:000324(time_t t0) = EVENT_STATE(CCTO:000324, t0)" xsd:string ! schema unknown_t ''Nausea and vomiting''(time_t t0) = EVENT_STATE(''Nausea and vomiting'', t0) is_a: CCTO:000049 ! Adverse events union_of: CCTO:000333 ! Nausea union_of: CCTO:000554 ! Vomiting relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000325 name: Late complications property_value: ESCORT_rule "CCTO:000325 implies CCTO:000049" xsd:string ! ESCORT_rule ''Late complications'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000325 implies CCTO:000137" xsd:string ! ESCORT_rule ''Late complications'' implies ''Complications'' property_value: schema "event_t CCTO:000325(time_t t0) = EVENT_STATE(CCTO:000325, t0)" xsd:string ! schema event_t ''Late complications''(time_t t0) = EVENT_STATE(''Late complications'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000137 ! Complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000326 name: Infection rate property_value: schema "probability_t CCTO:000326(time_t t0) = probability(CCTO:000129, t0)" xsd:string ! schema probability_t ''Infection Rate''(time_t t0) = probability(''Infections'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000129 ! is_probability_of Infections [Term] id: CCTO:000327 name: CNS progression property_value: ESCORT_rule "CCTO:000327 implies CCTO:000064" xsd:string ! ESCORT_rule ''CNS progression'' implies ''Disease progression'' property_value: schema "event_t CCTO:000327(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000327, t0, assessed_at)" xsd:string ! schema event_t ''CNS progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''CNS progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000328 name: Time to CNS progression property_value: ESCORT_rule "CCTO:000328 = time-to-first CCTO:000327" xsd:string ! ESCORT_rule ''Time to CNS progression'' = time-to-first ''CNS progression'' property_value: schema "duration_t CCTO:000328(time_t t0) = time_to_first_event(CCTO:000327, t0)" xsd:string ! schema duration_t ''Time to CNS progression''(time_t t0) = time_to_first_event(''CNS progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000329 name: Time to PSA response property_value: ESCORT_rule "CCTO:000329 = time-to-first CCTO:000120" xsd:string ! ESCORT_rule ''Time to PSA response'' = time-to-first ''PSA response'' property_value: schema "duration_t CCTO:000329(time_t t0) = time_to_first_event(CCTO:000120, t0)" xsd:string ! schema duration_t ''Time to PSA response''(time_t t0) = time_to_first_event(''PSA response'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000330 name: Relapse related mortality property_value: schema "event_t CCTO:000330(time_t t0) = CCTO:000114(t0) AND ASSOCIATED(CCTO:000114, CCTO:000081)" xsd:string ! schema event_t ''Relapse Related Mortality''(time_t t0) = ''Death''(t0) AND ASSOCIATED(''Death'', ''Relapse'') is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000331 name: Bone marrow response property_value: schema "event_t CCTO:000331(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000331, t0, assessed_at)" xsd:string ! schema event_t ''Bone marrow response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Bone marrow response'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000332 name: Stent patency property_value: ESCORT_rule "CCTO:000332 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stent patency'' implies ''Adverse events'' property_value: schema "unknown_t CCTO:000332(time_t t0) = EVENT_STATE(CCTO:000332, t0)" xsd:string ! schema unknown_t ''Stent patency''(time_t t0) = EVENT_STATE(''Stent patency'', t0) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000049 ! Adverse events relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000333 name: Nausea def: "A disorder characterized by a queasy sensation and/or the urge to vomit OR A question about whether an individual is or was bothered by nausea OR A question about the usual severity of an individual's nausea OR A question about whether a person has or had nausea OR A question about how often an individual has or had nausea OR A question about how much nausea an individual experienced during the specified time period OR A question about an individual's distress from their nausea OR Upper abdominal discomfort associated with an urge to vomit." [NCI:CTCAE, NCIT:C125646, NCIT:C125304, NCIT:C91124, NCIT:C125272, NCIT:C107520, NCIT:C125336, NCIT:C3258] synonym: "Bothered by Nausea" EXACT [NCIT:C125646] synonym: "Frequency of Nausea" EXACT [NCIT:C125272] synonym: "Had nausea" EXACT [NCIT:C91124] synonym: "Have nausea" EXACT [NCIT:C91124] synonym: "Have you felt nauseated" EXACT [NCIT:C91124] synonym: "How much distress nausea" EXACT [NCIT:C125336] synonym: "How much nausea during this period" EXACT [NCIT:C107520] synonym: "How often nausea" EXACT [NCIT:C125272] synonym: "How much nausea did you have during this period" EXACT [NCIT:C107520] synonym: "I have nausea" EXACT [NCIT:C91124] synonym: "Nausea adverse event" EXACT [NCIT:C57839] synonym: "Nausea frequency" EXACT [NCIT:C107520] synonym: "Nausea frequency" EXACT [NCIT:C125272] synonym: "Usual severity nausea" EXACT [NCIT:C125304] xref: UMLS:C0027497 xref: UMLS:C2984057 xref: UMLS:C3829611 xref: UMLS:C1963179 xref: NCI:CTCAE:10028813 xref: NCIT:C107520 xref: NCIT:C125272 xref: NCIT:C125304 xref: NCIT:C125336 xref: NCIT:C125646 xref: NCIT:C3258 xref: NCIT:C57839 xref: NCIT:C91124 property_value: ESCORT_rule "CCTO:000333 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nausea'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000333 implies CCTO:001108" xsd:string ! ESCORT_rule ''Nausea'' implies ''Gastrointestinal disorders'' is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000334 name: Bone pain def: "Painful sensation in the bones OR A disorder characterized by marked discomfort sensation in the bones." [NCIT:C38644, NCI:CTCAE] synonym: "Bone pain (diffuse not joint pain or arthritis)" EXACT [NCIT:C38644] xref: UMLS:C0151825 xref: NCI:CTCAE:10006002 xref: NCIT:C38644 property_value: ESCORT_rule "CCTO:000334 implies CCTO:000107" xsd:string ! ESCORT_rule ''Bone pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000334 implies CCTO:001109" xsd:string ! ESCORT_rule ''Bone pain'' implies ''Musculoskeletal and connective tissue disorders'' is_a: CCTO:000107 ! Pain is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000335 name: Time to radiographic progression property_value: schema "duration_t CCTO:000335(time_t t0) = time_to_first_event(CCTO:000112, t0)" xsd:string ! schema duration_t ''Time to radiographic progression''(time_t t0) = time_to_first_event(''Radiographic progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000336 name: Untreatable progression property_value: ESCORT_rule "CCTO:000336 implies CCTO:000064" xsd:string ! ESCORT_rule ''Untreatable progression'' implies ''Disease progression'' property_value: schema "event_t CCTO:000336(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000336, t0, assessed_at)" xsd:string ! schema event_t ''Untreatable progression''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Untreatable progression'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000337 name: Time to untreatable progression property_value: ESCORT_rule "CCTO:000337 = time-to-first CCTO:000336" xsd:string ! ESCORT_rule ''Time to untreatable progression'' = time-to-first ''Untreatable progression'' property_value: schema "duration_t CCTO:000337(time_t t0) = time_to_first_event(CCTO:000336, t0)" xsd:string ! schema duration_t ''Time to untreatable progression''(time_t t0) = time_to_first_event(''Untreatable progression'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000338 name: Breast cancer specific survival property_value: schema "duration_t CCTO:000338(time_t t0) = EVENT_STATE(CCTO:001110, t0) ? CCTO:000062(t0) : NULL" xsd:string ! schema duration_t ''Breast cancer specific survival''(time_t t0) = EVENT_STATE(''Breast cancer specific death'', t0) ? ''Overall survival''(t0) : NULL is_a: CCTO:000105 ! Disease-specific survival relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000339 name: Time to skeletal-related event property_value: schema "duration_t CCTO:000339(time_t t0) = time_to_first_event(CCTO:000166, t0)" xsd:string ! schema duration_t ''Time to skeletal-related event''(time_t t0) = time_to_first_event(''Skeletal-related event'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000340 name: Pain control property_value: ESCORT_rule "CCTO:000340 implies CCTO:000043" xsd:string ! ESCORT_rule ''Pain control'' implies ''Measure of safety'' property_value: ESCORT_rule "CCTO:000340 implies NOT CCTO:000130" xsd:string ! ESCORT_rule ''Pain control'' implies NOT ''Pain progression'' property_value: schema "event_t CCTO:000340(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000340, t0, assessed_at)" xsd:string ! schema event_t ''Pain control''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Pain control'', t0, assessed_at) is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000043 ! Measure of safety disjoint_from: CCTO:000130 ! Pain progression xref: UMLS:C1304888 xref: UMLS:C0002766 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000341 name: Hematologic toxicity synonym: "Haematologic toxicity" [] synonym: "Haematological toxicity" [] synonym: "Hematological toxicity" [] synonym: "Hematotoxicity" [] property_value: ESCORT_rule "CCTO:000341 implies CCTO:001112" xsd:string ! ESCORT_rule ''Hematologic toxicity'' implies ''Blood and lymphatic system disorders'' property_value: ESCORT_rule "CCTO:000341 implies NOT CCTO:000256" xsd:string ! ESCORT_rule ''Hematologic toxicity'' implies NOT ''Hematologic improvement'' property_value: schema "event_t CCTO:000341(time_t t0) = EVENT_STATE(CCTO:000341, t0)" xsd:string ! schema event_t ''Hematologic toxicity''(time_t t0) = EVENT_STATE(''Hematologic toxicity'', t0) is_a: CCTO:000048 ! Toxicity disjoint_from: CCTO:000256 ! Hematologic improvement relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000342 name: Biological progression-free synonym: "Biological progression free" [] property_value: ESCORT_rule "CCTO:000342 implies NOT CCTO:001111" xsd:string ! ESCORT_rule ''Biological progression-free'' implies NOT ''Biological Progression'' property_value: ESCORT_rule "NOT CCTO:000342 implies CCTO:001111" xsd:string ! ESCORT_rule NOT ''Biological progression-free'' implies ''Biological Progression'' property_value: schema "event_t CCTO:000342(time_t t0, time_t assessed_at) = NOT CCTO:001111(t0, assessed_at)" xsd:string ! schema event_t ''Biological progression-free''(time_t t0, time_t assessed_at) = NOT ''Biological Progression''(t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:001111 ! Biological Progression relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000343 name: Biological progression-free interval synonym: "Biological progression free interval" [] property_value: ESCORT_rule "CCTO:000343 = time-to-first CCTO:001111" xsd:string ! ESCORT_rule ''Biological progression-free interval'' = time-to-first ''Biological Progression'' property_value: schema "duration_t CCTO:000343(time_t t0) = time_to_first_event(CCTO:001111, t0)" xsd:string ! schema duration_t ''Biological progression-free interval''(time_t t0) = time_to_first_event(''Biological Progression'', t0) is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000344 name: Immune-related objective response synonym: "Immune-related disease response" [] property_value: ESCORT_rule "CCTO:000344 implies CCTO:000065" xsd:string ! ESCORT_rule ''Immune-related objective response'' implies ''Treatment response'' property_value: has_operator CCTO:000013 ! has_operator is_probability_of property_value: schema "event_t CCTO:000344(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000344, t0, assessed_at)" xsd:string ! schema event_t ''Immune-related objective response''(time_t t0, time_t assessed_at) = EVENT_COMPARISON(''Immune-related objective response'', t0, assessed_at) is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000345 name: Immune-related objective response rate property_value: schema "probability_t CCTO:000345(time_t t0) = probability(CCTO:000344, t0)" xsd:string ! schema probability_t ''Immune-related objective response rate''(time_t t0) = probability(''Immune-related objective response'', t0) is_a: CCTO:000004 ! Probability is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000004 ! has_value_type Probability relationship: CCTO:000013 CCTO:000344 ! is_probability_of Immune-related objective response [Term] id: CCTO:000346 name: Long term survival property_value: schema "duration_t CCTO:000346(time_t t0) = EVENT_STATE(CCTO:000346, t0)" xsd:string ! schema duration_t ''Long term survival''(time_t t0) = EVENT_STATE(''Long term survival'', t0) is_a: CCTO:000003 ! duration is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000003 ! has_value_type Duration [Term] id: CCTO:000347 name: National Cancer Institute Common Terminology Criteria for Adverse Events def: "A standard terminology developed to report adverse events occurring in cancer clinical trials. Common terminology criteria for adverse events (CTCAE) are used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTCAE contain a grading scale for each adverse event term representing the severity of the event OR A standard terminology developed to report adverse events occurring in cancer clinical trials. Common toxicity criteria (CTC) is used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTC contains a grading scale for each adverse event term representing the severity of the event. (NCI)" [NCIT:C49704, NCIT:C25468] synonym: "NCI CTCAE version 4.0" [] synonym: "NCI CTCAE" [] synonym: "CTCAE Grades" EXACT [NCIT:C49704] synonym: "CTCAE v3.0" [] synonym: "CTCAE v4.0" [] synonym: "CTCAE v4.03" [] synonym: "CTCAE" EXACT [NCIT:C25468] synonym: "CTCAE" EXACT [NCIT:C49704] synonym: "Common Terminology Criteria for Adverse Events" EXACT [NCIT:C25468] synonym: "Common Terminology Criteria for Adverse Events" EXACT [NCIT:C49704] synonym: "Common Toxicity Criteria for Adverse Events" EXACT [NCIT:C49704] synonym: "Common Toxicity Criteria" EXACT [NCIT:C25468] synonym: "Common Toxicity Criteria" EXACT [NCIT:C49704] synonym: "NCI CTCAE v3.0" [] synonym: "NCI CTCAE version 3.0" [] synonym: "Standard toxicity grade" EXACT [NCIT:C49704] xref: UMLS:C1516728 xref: NCIT:C25468 xref: NCIT:C49704 property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000053 ! Clinical criteria relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000348 name: EORTC QLQ-C30 questionnaire synonym: "EORTC QLQ-C30" [] synonym: "health-related quality of life on the 4- and 7-point EORTC QLQ-C30" [] synonym: "the EORTC QLQ-C30 Dyspnea" [] synonym: "the EORTC QLQ-C30 Global Health Status-/Quality of Life Domain" [] synonym: "the EORTC QLQ-C30 Physical Functioning Domain" [] property_value: ESCORT_rule "CCTO:000348 implies CCTO:000118" xsd:string ! ESCORT_rule ''EORTC QLQ-C30 questionnaire'' implies ''Patient reported outcomes'' property_value: schema "event_t NULL" xsd:string ! schema is_a: CCTO:000023 ! Measure of quality of life is_a: CCTO:000118 ! Patient reported outcomes relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000349 name: Response Evaluation Criteria in Solid Tumors def: "Standard parameters to be used when documenting response of solid tumors to treatment; a set of published rules that define when cancer patients improve (''respond''), stay the same (''stable''), or worsen (''progression'') during treatments. (from www.recist.com)" [NCIT:C49164] synonym: "RECIST criteria" [] synonym: "RECIST" EXACT [NCIT:C49164] xref: UMLS:C1709926 xref: NCIT:C49164 property_value: schema "unknown_t NULL" xsd:string ! schema is_a: CCTO:000031 ! Measure of efficacy is_a: CCTO:000053 ! Clinical criteria relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:000350 name: Surgery-related concept def: "A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery OR The branch of medical science that treats disease or injury by operative procedures." [NCIT:C15329, NCIT:C17173] synonym: "Operation" EXACT [NCIT:C15329] synonym: "Surgery" EXACT [NCIT:C15329] synonym: "Surgery" EXACT [NCIT:C17173] synonym: "Surgical interventions" EXACT [NCIT:C15329] synonym: "Surgical procedure" EXACT [NCIT:C15329] synonym: "Surgical procedures" EXACT [NCIT:C15329] synonym: "Surgical" EXACT [NCIT:C15329] synonym: "Surgically" EXACT [NCIT:C15329] xref: UMLS:C0543467 xref: UMLS:C0038895 xref: UMLS:C0038894 xref: UMLS:C1552276 xref: NCIT:C15329 xref: NCIT:C17173 is_a: CCTO:000029 ! Cancer treatment-related concept [Term] id: CCTO:000351 name: Disease clearance is_a: CCTO:000031 ! Measure of efficacy [Term] id: CCTO:000352 name: Subjective assessment is_a: CCTO:000050 ! Assessment tool [Term] id: CCTO:000353 name: Dermatologic concept def: "A medical specialty concerned with the skin, its structure, functions, diseases, and treatment. (MeSH)" [NCIT:C16500] synonym: "Dermatology" EXACT [NCIT:C16500] xref: UMLS:C0011627 xref: UMLS:C0259831 xref: NCIT:C16500 is_a: CCTO:000017 ! Physical health-related concept [Term] id: CCTO:000354 name: Anemia def: "A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability OR A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability." [NCI:CTCAE, NCIT:C2869] xref: UMLS:C0002871 xref: UMLS:C1000483 xref: NCI:CTCAE:10002272 xref: NCIT:C2869 property_value: ESCORT_rule "CCTO:000354 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000354 implies CCTO:001112" xsd:string ! ESCORT_rule ''Anemia'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000354(time_t t0) = EVENT_STATE(CCTO:000354, t0)" xsd:string ! schema ''Anemia''(time_t t0) = EVENT_STATE(''Anemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000355 name: Bone marrow hypocellular def: "A laboratory finding indicating decreased number of hematopoietic cells in the bone marrow. It may result from decreased proliferation of all or part of the hematopoietic series (erythroid, myeloid, and megakaryocytic). Microscopically, the hematopoietic cells are replaced by adipocytes OR A disorder characterized by the inability of the bone marrow to produce hematopoietic elements." [NCIT:C35167, NCI:CTCAE] synonym: "Bone marrow hypoplasia" EXACT [NCIT:C35167] synonym: "Hypocellular bone marrow" EXACT [NCIT:C35167] xref: UMLS:C0151773 xref: NCI:CTCAE:10048580 xref: NCIT:C35167 property_value: ESCORT_rule "CCTO:000355 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bone marrow hypocellular'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000355 implies CCTO:001112" xsd:string ! ESCORT_rule ''Bone marrow hypocellular'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000355(time_t t0) = EVENT_STATE(CCTO:000355, t0)" xsd:string ! schema ''Bone marrow hypocellular''(time_t t0) = EVENT_STATE(''Bone marrow hypocellular'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000356 name: Disseminated intravascular coagulation def: "A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors OR A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage." [NCI:CTCAE, NCIT:C2992] synonym: "Coagulation (DIC), Disseminated Intravascular" EXACT [NCIT:C2992] synonym: "Consumptive coagulopathy" EXACT [NCIT:C2992] synonym: "DIC" EXACT [NCIT:C2992] synonym: "DIC, Disseminated Intravascular Coagulation" EXACT [NCIT:C2992] synonym: "Disseminated Intravascular Coagulation (DIC)" EXACT [NCIT:C2992] synonym: "Intravascular Coagulation (DIC), Disseminated" EXACT [NCIT:C2992] xref: UMLS:C0012739 xref: UMLS:C0333710 xref: NCI:CTCAE:10013442 xref: NCIT:C2992 property_value: ESCORT_rule "CCTO:000356 implies CCTO:000049" xsd:string ! ESCORT_rule ''Disseminated intravascular coagulation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000356 implies CCTO:001112" xsd:string ! ESCORT_rule ''Disseminated intravascular coagulation'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000356(time_t t0) = EVENT_STATE(CCTO:000356, t0)" xsd:string ! schema ''Disseminated intravascular coagulation''(time_t t0) = EVENT_STATE(''Disseminated intravascular coagulation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000357 name: Febrile neutropenia def: "Neutropenia associated with fever, the latter indicating the presence of an infection OR A disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour" [NCIT:C35665, NCI:CTCAE] xref: UMLS:C0746883 xref: NCI:CTCAE:10016288 xref: NCIT:C35665 property_value: ESCORT_rule "CCTO:000357 implies CCTO:000049" xsd:string ! ESCORT_rule ''Febrile neutropenia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000357 implies CCTO:001112" xsd:string ! ESCORT_rule ''Febrile neutropenia'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000357(time_t t0) = EVENT_STATE(CCTO:000357, t0)" xsd:string ! schema ''Febrile neutropenia''(time_t t0) = EVENT_STATE(''Febrile neutropenia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000358 name: Hemolysis def: "A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction OR Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin OR The determination of the amount of destruction of red blood cells present in a sample." [NCI:CTCAE, NCIT:C37965, NCIT:C111208] synonym: "HEMOLYSI" EXACT [NCIT:C111208] synonym: "Hemolytic Index" EXACT [NCIT:C111208] synonym: "Hemolytic" EXACT [NCIT:C37965] xref: UMLS:C2937287 xref: UMLS:C3814778 xref: UMLS:C2945560 xref: UMLS:C0312853 xref: NCI:CTCAE:10019491 xref: NCIT:C111208 xref: NCIT:C37965 property_value: ESCORT_rule "CCTO:000358 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hemolysis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000358 implies CCTO:001112" xsd:string ! ESCORT_rule ''Hemolysis'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000358(time_t t0) = EVENT_STATE(CCTO:000358, t0)" xsd:string ! schema ''Hemolysis''(time_t t0) = EVENT_STATE(''Hemolysis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000359 name: Hemolytic uremic syndrome def: "A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia OR Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia." [NCI:CTCAE, NCIT:C75545] synonym: "Hemolytic-uremic syndrome" EXACT [NCIT:C75545] xref: UMLS:C0019061 xref: NCI:CTCAE:10019515 xref: NCIT:C75545 property_value: ESCORT_rule "CCTO:000359 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hemolytic uremic syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000359 implies CCTO:001112" xsd:string ! ESCORT_rule ''Hemolytic uremic syndrome'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000359(time_t t0) = EVENT_STATE(CCTO:000359, t0)" xsd:string ! schema ''Hemolytic uremic syndrome''(time_t t0) = EVENT_STATE(''Hemolytic uremic syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000360 name: Leukocytosis def: "A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood OR A laboratory test result indicating an increased number of white blood cells in the peripheral blood." [NCI:CTCAE, NCIT:C35524] synonym: "WBC Increased" EXACT [NCIT:C35524] synonym: "White blood cell count increased" EXACT [NCIT:C35524] xref: UMLS:C0750426 xref: UMLS:C0023518 xref: NCI:CTCAE:10024378 xref: NCIT:C35524 property_value: ESCORT_rule "CCTO:000360 implies CCTO:000049" xsd:string ! ESCORT_rule ''Leukocytosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000360 implies CCTO:001112" xsd:string ! ESCORT_rule ''Leukocytosis'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000360(time_t t0) = EVENT_STATE(CCTO:000360, t0)" xsd:string ! schema ''Leukocytosis''(time_t t0) = EVENT_STATE(''Leukocytosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000361 name: Lymph node pain def: "A painful sensation in a lymph node OR A disorder characterized by a sensation of marked discomfort in a lymph node." [NCIT:C78440, NCI:CTCAE] synonym: "Lymph node pain adverse event" EXACT [NCIT:C56120] xref: UMLS:C1963194 xref: UMLS:C0578050 xref: NCI:CTCAE:10025182 xref: NCIT:C56120 xref: NCIT:C78440 property_value: ESCORT_rule "CCTO:000361 implies CCTO:000107" xsd:string ! ESCORT_rule ''Lymph node pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000361 implies CCTO:001112" xsd:string ! ESCORT_rule ''Lymph node pain'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000361(time_t t0) = EVENT_STATE(CCTO:000361, t0)" xsd:string ! schema ''Lymph node pain''(time_t t0) = EVENT_STATE(''Lymph node pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000362 name: Spleen disorder def: "A non-neoplastic or neoplastic disorder affecting the spleen. Examples include infection, hemangioma, lymphoma, leukemia and angiosarcoma OR A disorder of the spleen." [NCIT:C35823, NCI:CTCAE] synonym: "Splenic disorder" EXACT [NCIT:C35823] xref: UMLS:C0037997 xref: NCI:CTCAE:10041633 xref: NCIT:C35823 property_value: ESCORT_rule "CCTO:000362 implies CCTO:000049" xsd:string ! ESCORT_rule ''Spleen disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000362 implies CCTO:001112" xsd:string ! ESCORT_rule ''Spleen disorder'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000362(time_t t0) = EVENT_STATE(CCTO:000362, t0)" xsd:string ! schema ''Spleen disorder''(time_t t0) = EVENT_STATE(''Spleen disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000363 name: Thrombotic thrombocytopenic purpura def: "A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction OR A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition." [NCIT:C78797, NCI:CTCAE] synonym: "Moschowitz disease" EXACT [NCIT:C78797] xref: UMLS:C0034155 xref: NCI:CTCAE:10043648 xref: NCIT:C78797 property_value: ESCORT_rule "CCTO:000363 implies CCTO:000049" xsd:string ! ESCORT_rule ''Thrombotic thrombocytopenic purpura'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000363 implies CCTO:001112" xsd:string ! ESCORT_rule ''Thrombotic thrombocytopenic purpura'' implies ''Blood and lymphatic system disorders'' property_value: schema "CCTO:000363(time_t t0) = EVENT_STATE(CCTO:000363, t0)" xsd:string ! schema ''Thrombotic thrombocytopenic purpura''(time_t t0) = EVENT_STATE(''Thrombotic thrombocytopenic purpura'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001112 ! Blood and lymphatic system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000364 name: Acute coronary syndrome def: "Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction OR A disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction." [NCIT:C53652, NCI:CTCAE] xref: UMLS:C0948089 xref: NCI:CTCAE:10051592 xref: NCIT:C53652 property_value: ESCORT_rule "CCTO:000364 implies CCTO:000049" xsd:string ! ESCORT_rule ''Acute coronary syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000364 implies CCTO:001113" xsd:string ! ESCORT_rule ''Acute coronary syndrome'' implies ''Cardiac disorders'' property_value: schema "CCTO:000364(time_t t0) = EVENT_STATE(CCTO:000364, t0)" xsd:string ! schema ''Acute coronary syndrome''(time_t t0) = EVENT_STATE(''Acute coronary syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000365 name: Aortic valve disease def: "A heart disorder characterized by a defect in aortic valve structure or function OR A disorder characterized by a defect in aortic valve function or structure." [NCIT:C78650, NCI:CTCAE] synonym: "Aortic valve disorder" EXACT [NCIT:C78650] xref: UMLS:C1260873 xref: NCI:CTCAE:10061589 xref: NCIT:C78650 property_value: ESCORT_rule "CCTO:000365 implies CCTO:000049" xsd:string ! ESCORT_rule ''Aortic valve disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000365 implies CCTO:001113" xsd:string ! ESCORT_rule ''Aortic valve disease'' implies ''Cardiac disorders'' property_value: schema "CCTO:000365(time_t t0) = EVENT_STATE(CCTO:000365, t0)" xsd:string ! schema ''Aortic valve disease''(time_t t0) = EVENT_STATE(''Aortic valve disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000366 name: Asystole def: "A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart OR An electrocardiographic finding showing no cardiac electrical activity on the monitor or printed strip for the entire duration of the recording. (CDISC) OR The sudden cessation of cardiac activity in an individual who becomes unresponsive, without normal breathing and no signs of circulation. Cardiac arrest may be reversed by CPR, and/or defibrillation, cardioversion or cardiac pacing." [NCI:CTCAE, NCIT:C116130, NCIT:C50479] synonym: "Arrest, cardiac" EXACT [NCIT:C50479] synonym: "Asystole adverse event" EXACT [NCIT:C54766] synonym: "Asystole by ECG Finding" EXACT [NCIT:C116130] synonym: "Cardiac arrest" EXACT [NCIT:C50479] synonym: "Heart arrest" EXACT [NCIT:C50479] xref: UMLS:C0018790 xref: UMLS:C1963122 xref: NCI:CTCAE:10003586 xref: NCI:CTCAE:10007515 xref: NCIT:C116130 xref: NCIT:C50479 xref: NCIT:C54766 property_value: ESCORT_rule "CCTO:000366 implies CCTO:000049" xsd:string ! ESCORT_rule ''Asystole'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000366 implies CCTO:001113" xsd:string ! ESCORT_rule ''Asystole'' implies ''Cardiac disorders'' property_value: schema "CCTO:000366(time_t t0) = EVENT_STATE(CCTO:000366, t0)" xsd:string ! schema ''Asystole''(time_t t0) = EVENT_STATE(''Asystole'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000367 name: Atrial fibrillation def: "A disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles OR An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC) OR A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)" [NCI:CTCAE, NCIT:C111092, NCIT:C50466] synonym: "AF" EXACT [NCIT:C111092] synonym: "AF" EXACT [NCIT:C50466] synonym: "AFib" EXACT [NCIT:C111092] synonym: "AFib" EXACT [NCIT:C50466] synonym: "Atrial fibrillation adverse event" EXACT [NCIT:C54767] synonym: "Atrial Fibrillation by ECG Finding" EXACT [NCIT:C111092] synonym: "Atrial Fibrillation by EKG Finding" EXACT [NCIT:C111092] xref: UMLS:C0344434 xref: UMLS:C0004238 xref: UMLS:C1963067 xref: NCI:CTCAE:10003658 xref: NCIT:C111092 xref: NCIT:C50466 xref: NCIT:C54767 property_value: ESCORT_rule "CCTO:000367 implies CCTO:000049" xsd:string ! ESCORT_rule ''Atrial fibrillation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000367 implies CCTO:001113" xsd:string ! ESCORT_rule ''Atrial fibrillation'' implies ''Cardiac disorders'' property_value: schema "CCTO:000367(time_t t0) = EVENT_STATE(CCTO:000367, t0)" xsd:string ! schema ''Atrial fibrillation''(time_t t0) = EVENT_STATE(''Atrial fibrillation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000368 name: Atrial flutter def: "A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) OR An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC) OR A disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria." [NCIT:C51224, NCIT:C111094, NCI:CTCAE] synonym: "Atrial flutter adverse event" EXACT [NCIT:C54768] synonym: "Atrial Flutter by ECG Finding" EXACT [NCIT:C111094] synonym: "Atrial Flutter by EKG Finding" EXACT [NCIT:C111094] xref: UMLS:C0344423 xref: UMLS:C1963068 xref: UMLS:C0004239 xref: NCI:CTCAE:10003662 xref: NCIT:C111094 xref: NCIT:C51224 xref: NCIT:C54768 property_value: ESCORT_rule "CCTO:000368 implies CCTO:000049" xsd:string ! ESCORT_rule ''Atrial flutter'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000368 implies CCTO:001113" xsd:string ! ESCORT_rule ''Atrial flutter'' implies ''Cardiac disorders'' property_value: schema "CCTO:000368(time_t t0) = EVENT_STATE(CCTO:000368, t0)" xsd:string ! schema ''Atrial flutter''(time_t t0) = EVENT_STATE(''Atrial flutter'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000369 name: Atrioventricular block complete def: "A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles OR A disorder characterized by an electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC)" [NCI:CTCAE, NCIT:C50501] synonym: "AV Block Third Degree" EXACT [NCIT:C50501] synonym: "Atrioventricular block, third degree" EXACT [NCIT:C50501] synonym: "Complete AV Block" EXACT [NCIT:C50501] synonym: "Complete atrioventricular block" EXACT [NCIT:C50501] synonym: "Complete heart block" EXACT [NCIT:C50501] synonym: "Non-congenital complete atrioventricular block" EXACT [NCIT:C50501] synonym: "Third Degree AV Block" EXACT [NCIT:C50501] synonym: "Third degree atrioventricular block" EXACT [NCIT:C50501] xref: UMLS:C0151517 xref: UMLS:C2215935 xref: NCI:CTCAE:10003673 xref: NCIT:C50501 property_value: ESCORT_rule "CCTO:000369 implies CCTO:000049" xsd:string ! ESCORT_rule ''Atrioventricular block complete'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000369 implies CCTO:001113" xsd:string ! ESCORT_rule ''Atrioventricular block complete'' implies ''Cardiac disorders'' property_value: schema "CCTO:000369(time_t t0) = EVENT_STATE(CCTO:000369, t0)" xsd:string ! schema ''Atrioventricular block complete''(time_t t0) = EVENT_STATE(''Atrioventricular block complete'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000370 name: Atrioventricular block first degree def: "A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds OR A disorder characterized by an electrocardiographic finding of prolonged PR interval for a specific population. For adults one common threshold is a PR interval greater than 0.20 seconds." [NCI:CTCAE, NCIT:C62015] synonym: "AV Block First Degree" EXACT [NCIT:C62015] synonym: "Atrioventricular block, first degree" EXACT [NCIT:C62015] synonym: "First Degree AV Block" EXACT [NCIT:C62015] synonym: "First degree atrioventricular block" EXACT [NCIT:C62015] xref: UMLS:C0085614 xref: UMLS:C3715208 xref: NCI:CTCAE:10003674 xref: NCIT:C62015 property_value: ESCORT_rule "CCTO:000370 implies CCTO:000049" xsd:string ! ESCORT_rule ''Atrioventricular block first degree'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000370 implies CCTO:001113" xsd:string ! ESCORT_rule ''Atrioventricular block first degree'' implies ''Cardiac disorders'' property_value: schema "CCTO:000370(time_t t0) = EVENT_STATE(CCTO:000370, t0)" xsd:string ! schema ''Atrioventricular block first degree''(time_t t0) = EVENT_STATE(''Atrioventricular block first degree'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000371 name: Chest pain - cardiac def: "Paroxysms of chest pain due to reduced oxygen to the heart OR A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation." [NCIT:C51221, NCI:CTCAE] synonym: "Angina pectoris" EXACT [NCIT:C51221] synonym: "Angina" EXACT [NCIT:C51221] xref: UMLS:C0002962 xref: UMLS:C2926611 xref: NCI:CTCAE:10008481 xref: NCIT:C51221 property_value: ESCORT_rule "CCTO:000371 implies CCTO:000107" xsd:string ! ESCORT_rule ''Chest pain - cardiac'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000371 implies CCTO:001113" xsd:string ! ESCORT_rule ''Chest pain - cardiac'' implies ''Cardiac disorders'' property_value: schema "CCTO:000371(time_t t0) = EVENT_STATE(CCTO:000371, t0)" xsd:string ! schema ''Chest pain - cardiac''(time_t t0) = EVENT_STATE(''Chest pain - cardiac'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000372 name: Conduction disorder def: "A disorder affecting the conduction system that sends electrical signals in the myocardium OR A disorder characterized by pathological irregularities in the cardiac conduction system." [NCIT:C78245, NCI:CTCAE] synonym: "Cardiac conduction disorder" EXACT [NCIT:C78245] synonym: "Disorder of Cardiac Conduction" EXACT [NCIT:C78245] synonym: "Heart conduction disorder" EXACT [NCIT:C78245] xref: UMLS:C0264886 xref: NCI:CTCAE:10010276 xref: NCIT:C78245 property_value: ESCORT_rule "CCTO:000372 implies CCTO:000049" xsd:string ! ESCORT_rule ''Conduction disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000372 implies CCTO:001113" xsd:string ! ESCORT_rule ''Conduction disorder'' implies ''Cardiac disorders'' property_value: schema "CCTO:000372(time_t t0) = EVENT_STATE(CCTO:000372, t0)" xsd:string ! schema ''Conduction disorder''(time_t t0) = EVENT_STATE(''Conduction disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000373 name: Constrictive pericarditis def: "A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action OR A heart disorder in which the pericardial sac becomes thickened and fibrotic, tightening the myocardium and impeding the normal myocardial function." [NCI:CTCAE, NCIT:C78246] xref: UMLS:C0031048 xref: NCI:CTCAE:10010783 xref: NCIT:C78246 property_value: ESCORT_rule "CCTO:000373 implies CCTO:000049" xsd:string ! ESCORT_rule ''Constrictive pericarditis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000373 implies CCTO:001113" xsd:string ! ESCORT_rule ''Constrictive pericarditis'' implies ''Cardiac disorders'' property_value: schema "CCTO:000373(time_t t0) = EVENT_STATE(CCTO:000373, t0)" xsd:string ! schema ''Constrictive pericarditis''(time_t t0) = EVENT_STATE(''Constrictive pericarditis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000374 name: Heart failure def: "A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure OR Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction." [NCI:CTCAE, NCIT:C50577] synonym: "Cardiac failure" EXACT [NCIT:C50577] synonym: "Cardiac insufficiency" EXACT [NCIT:C50577] synonym: "Failure, heart" EXACT [NCIT:C50577] synonym: "Insufficiency, cardiac" EXACT [NCIT:C50577] xref: UMLS:C0018801 xref: UMLS:C0018802 xref: NCI:CTCAE:10019279 xref: NCIT:C50577 property_value: ESCORT_rule "CCTO:000374 implies CCTO:000049" xsd:string ! ESCORT_rule ''Heart failure'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000374 implies CCTO:001113" xsd:string ! ESCORT_rule ''Heart failure'' implies ''Cardiac disorders'' property_value: schema "CCTO:000374(time_t t0) = EVENT_STATE(CCTO:000374, t0)" xsd:string ! schema ''Heart failure''(time_t t0) = EVENT_STATE(''Heart failure'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000375 name: Left ventricular systolic dysfunction def: "A disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations may include dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema OR The degree of impairment of the left cardiac ventricle to contract efficiently. (ACC) OR Defined in terms of ejection fraction, a good clinical indicator of ventricular systolic function. Normal ejection fraction is 0.50 or more (>50%). Left ventricular systolic dysfunction is generally defined as an ejection fraction equal to or less than 0.40 (<40%)." [NCI:CTCAE, NCIT:C64251, NCIT:C55063] synonym: "Left cardiac ventricular systolic dysfunction" EXACT [NCIT:C64251] synonym: "Left ventricular systolic dysfunction adverse event" EXACT [NCIT:C55063] xref: UMLS:C1277187 xref: UMLS:C1963159 xref: NCI:CTCAE:10069501 xref: NCIT:C55063 xref: NCIT:C64251 property_value: ESCORT_rule "CCTO:000375 implies CCTO:000049" xsd:string ! ESCORT_rule ''Left ventricular systolic dysfunction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000375 implies CCTO:001113" xsd:string ! ESCORT_rule ''Left ventricular systolic dysfunction'' implies ''Cardiac disorders'' property_value: schema "CCTO:000375(time_t t0) = EVENT_STATE(CCTO:000375, t0)" xsd:string ! schema ''Left ventricular systolic dysfunction''(time_t t0) = EVENT_STATE(''Left ventricular systolic dysfunction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000376 name: Mitral valve disease def: "A heart disorder characterized by a defect in mitral valve structure or function OR A disorder characterized by a defect in mitral valve function or structure." [NCIT:C78446, NCI:CTCAE] synonym: "Mitral valve disorder" EXACT [NCIT:C78446] xref: UMLS:C0026265 xref: NCI:CTCAE:10061532 xref: NCIT:C78446 property_value: ESCORT_rule "CCTO:000376 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mitral valve disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000376 implies CCTO:001113" xsd:string ! ESCORT_rule ''Mitral valve disease'' implies ''Cardiac disorders'' property_value: schema "CCTO:000376(time_t t0) = EVENT_STATE(CCTO:000376, t0)" xsd:string ! schema ''Mitral valve disease''(time_t t0) = EVENT_STATE(''Mitral valve disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000377 name: Mobitz (type) II atrioventricular block def: "A disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles OR A disorder characterized by an electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a relatively constant PR interval prior to the block of an atrial impulse. (CDISC)" [NCI:CTCAE, NCIT:C62018] synonym: "AV Block Second Degree Mobitz Type II" EXACT [NCIT:C62018] synonym: "AV Block Second Degree Möbitz Type II" EXACT [NCIT:C62018] synonym: "Mobitz (type) II atrioventricular block" EXACT [NCIT:C62018] synonym: "Mobitz II" EXACT [NCIT:C62018] synonym: "Mobitz Type II Second Degree AV Block" EXACT [NCIT:C62018] synonym: "Möbitz II" EXACT [NCIT:C62018] synonym: "Möbitz Type II Second Degree AV Block" EXACT [NCIT:C62018] synonym: "Second Degree Atrioventricular Block Mobitz Type II" EXACT [NCIT:C62018] synonym: "Second Degree Atrioventricular Block Möbitz Type II" EXACT [NCIT:C62018] synonym: "Type 2 2nd degree AV Block" EXACT [NCIT:C62018] synonym: "Type 2 Second Degree AV Block" EXACT [NCIT:C62018] synonym: "Type II Second Degree AV Block" EXACT [NCIT:C62018] synonym: "Type II Second Degree Atrioventricular Block" EXACT [NCIT:C62018] xref: UMLS:C0155700 xref: UMLS:C3811815 xref: NCI:CTCAE:10027786 xref: NCIT:C62018 property_value: ESCORT_rule "CCTO:000377 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mobitz (type) II atrioventricular block'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000377 implies CCTO:001113" xsd:string ! ESCORT_rule ''Mobitz (type) II atrioventricular block'' implies ''Cardiac disorders'' property_value: schema "CCTO:000377(time_t t0) = EVENT_STATE(CCTO:000377, t0)" xsd:string ! schema ''Mobitz (type) II atrioventricular block''(time_t t0) = EVENT_STATE(''Mobitz (type) II atrioventricular block'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000378 name: Mobitz type I def: "A disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles OR A disorder characterized by an electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC)" [NCI:CTCAE, NCIT:C62017] synonym: "AV Block Second Degree Mobitz Type I" EXACT [NCIT:C62017] synonym: "AV Block Second Degree Möbitz Type I" EXACT [NCIT:C62017] synonym: "Mobitz I" EXACT [NCIT:C62017] synonym: "Mobitz Type I Second Degree AV Block" EXACT [NCIT:C62017] synonym: "Möbitz I" EXACT [NCIT:C62017] synonym: "Möbitz Type I Second Degree AV Block" EXACT [NCIT:C62017] synonym: "Second Degree Atrioventricular Block Mobitz Type I" EXACT [NCIT:C62017] synonym: "Second Degree Atrioventricular Block Möbitz Type I" EXACT [NCIT:C62017] synonym: "Type 1 2nd degree AV Block" EXACT [NCIT:C62017] synonym: "Type 1 Second Degree AV Block" EXACT [NCIT:C62017] synonym: "Type 1 Second Degree Atrioventricular Block" EXACT [NCIT:C62017] synonym: "Wenckebach block" EXACT [NCIT:C62017] xref: UMLS:C0264907 xref: UMLS:C3811814 xref: NCI:CTCAE:10027787 xref: NCIT:C62017 property_value: ESCORT_rule "CCTO:000378 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mobitz type I'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000378 implies CCTO:001113" xsd:string ! ESCORT_rule ''Mobitz type I'' implies ''Cardiac disorders'' property_value: schema "CCTO:000378(time_t t0) = EVENT_STATE(CCTO:000378, t0)" xsd:string ! schema ''Mobitz type I''(time_t t0) = EVENT_STATE(''Mobitz type I'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000379 name: Myocardial infarction def: "A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area OR An electrocardiographic assessment of findings that suggest the occurrence of a myocardial infarction OR An electrocardiographic finding of pathologic Q waves, which is suggestive of myocardial infarction of one or more regions of the heart. No specification is provided for localization. (CDISC) OR Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis." [NCI:CTCAE, NCIT:C111280, NCIT:C101589, NCIT:C27996] synonym: "Heart attack" EXACT [NCIT:C27996] synonym: "Infarction (MI), Myocardial" EXACT [NCIT:C27996] synonym: "MI" EXACT [NCIT:C111280] synonym: "MI" EXACT [NCIT:C27996] synonym: "MI, Myocardial Infarction" EXACT [NCIT:C27996] synonym: "Myocardial infarct" EXACT [NCIT:C27996] synonym: "Myocardial Infarction ECG Assessment" EXACT [NCIT:C111280] synonym: "Myocardial Infarction by ECG Finding" EXACT [NCIT:C101589] synonym: "Myocardial Infarction by EKG Finding" EXACT [NCIT:C101589] synonym: "Myocardial Infarction, (MI)" EXACT [NCIT:C27996] xref: UMLS:C0027051 xref: UMLS:C0428953 xref: UMLS:C3810814 xref: NCI:CTCAE:10028596 xref: NCIT:C101589 xref: NCIT:C111280 xref: NCIT:C27996 property_value: ESCORT_rule "CCTO:000379 implies CCTO:000049" xsd:string ! ESCORT_rule ''Myocardial infarction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000379 implies CCTO:001113" xsd:string ! ESCORT_rule ''Myocardial infarction'' implies ''Cardiac disorders'' property_value: schema "CCTO:000379(time_t t0) = EVENT_STATE(CCTO:000379, t0)" xsd:string ! schema ''Myocardial infarction''(time_t t0) = EVENT_STATE(''Myocardial infarction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000380 name: Myocarditis def: "Inflammation of the muscle tissue of the heart OR A disorder characterized by inflammation of the muscle tissue of the heart." [NCIT:C34831, NCI:CTCAE] synonym: "Myocarditis adverse event" EXACT [NCIT:C55064] xref: UMLS:C0027059 xref: UMLS:C1962971 xref: NCI:CTCAE:10028606 xref: NCIT:C34831 xref: NCIT:C55064 property_value: ESCORT_rule "CCTO:000380 implies CCTO:000049" xsd:string ! ESCORT_rule ''Myocarditis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000380 implies CCTO:001113" xsd:string ! ESCORT_rule ''Myocarditis'' implies ''Cardiac disorders'' property_value: schema "CCTO:000380(time_t t0) = EVENT_STATE(CCTO:000380, t0)" xsd:string ! schema ''Myocarditis''(time_t t0) = EVENT_STATE(''Myocarditis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000381 name: Palpitations def: "An unpleasant sensation of irregular and/or forceful beating of the heart OR A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart." [NCIT:C37999, NCI:CTCAE] synonym: "Palpitation" EXACT [NCIT:C37999] synonym: "Palpitations adverse event" EXACT [NCIT:C54935] xref: UMLS:C0030252 xref: UMLS:C3160712 xref: NCI:CTCAE:10033557 xref: NCIT:C37999 xref: NCIT:C54935 property_value: ESCORT_rule "CCTO:000381 implies CCTO:000049" xsd:string ! ESCORT_rule ''Palpitations'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000381 implies CCTO:001113" xsd:string ! ESCORT_rule ''Palpitations'' implies ''Cardiac disorders'' property_value: schema "CCTO:000381(time_t t0) = EVENT_STATE(CCTO:000381, t0)" xsd:string ! schema ''Palpitations''(time_t t0) = EVENT_STATE(''Palpitations'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000382 name: Paroxysmal atrial tachycardia def: "A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria OR A disorder characterized by an electrocardiographic finding of episodic atrial tachycardia with abrupt onset and termination." [NCI:CTCAE, NCIT:C34900] synonym: "PAT" EXACT [NCIT:C34900] synonym: "True paroxysmal atrial tachycardia" EXACT [NCIT:C34900] xref: UMLS:C0030587 xref: UMLS:C2248827 xref: UMLS:C2247346 xref: NCI:CTCAE:10034040 xref: NCIT:C34900 property_value: ESCORT_rule "CCTO:000382 implies CCTO:000049" xsd:string ! ESCORT_rule ''Paroxysmal atrial tachycardia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000382 implies CCTO:001113" xsd:string ! ESCORT_rule ''Paroxysmal atrial tachycardia'' implies ''Cardiac disorders'' property_value: schema "CCTO:000382(time_t t0) = EVENT_STATE(CCTO:000382, t0)" xsd:string ! schema ''Paroxysmal atrial tachycardia''(time_t t0) = EVENT_STATE(''Paroxysmal atrial tachycardia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000383 name: Pericardial effusion def: "Fluid collection within the pericardial sac, usually due to inflammation OR A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation." [NCIT:C3319, NCI:CTCAE] synonym: "FLUID, PERICARDIAL" EXACT [NCIT:C3319] synonym: "Pericardial fluid" EXACT [NCIT:C3319] xref: UMLS:C0031039 xref: UMLS:C0225973 xref: UMLS:C1253937 xref: UMLS:C1546730 xref: NCI:CTCAE:10034474 xref: NCIT:C3319 property_value: ESCORT_rule "CCTO:000383 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pericardial effusion'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000383 implies CCTO:001113" xsd:string ! ESCORT_rule ''Pericardial effusion'' implies ''Cardiac disorders'' property_value: schema "CCTO:000383(time_t t0) = EVENT_STATE(CCTO:000383, t0)" xsd:string ! schema ''Pericardial effusion''(time_t t0) = EVENT_STATE(''Pericardial effusion'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000384 name: Pericardial tamponade def: "A disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium OR Acute compression of the heart caused by increased intrapericardial pressure due to the collection of blood or fluid in the pericardium from rupture of the heart, penetrating trauma, or progressive effusion." [NCI:CTCAE, NCIT:C50481] synonym: "Cardiac tamponade" EXACT [NCIT:C50481] xref: UMLS:C0007177 xref: NCI:CTCAE:10053565 xref: NCIT:C50481 property_value: ESCORT_rule "CCTO:000384 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pericardial tamponade'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000384 implies CCTO:001113" xsd:string ! ESCORT_rule ''Pericardial tamponade'' implies ''Cardiac disorders'' property_value: schema "CCTO:000384(time_t t0) = EVENT_STATE(CCTO:000384, t0)" xsd:string ! schema ''Pericardial tamponade''(time_t t0) = EVENT_STATE(''Pericardial tamponade'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000385 name: Pericarditis def: "A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart) OR An inflammatory process affecting the pericardium." [NCI:CTCAE, NCIT:C34915] synonym: "Pericarditis adverse event" EXACT [NCIT:C55067] xref: UMLS:C1963211 xref: UMLS:C0031046 xref: NCI:CTCAE:10034484 xref: NCIT:C34915 xref: NCIT:C55067 property_value: ESCORT_rule "CCTO:000385 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pericarditis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000385 implies CCTO:001113" xsd:string ! ESCORT_rule ''Pericarditis'' implies ''Cardiac disorders'' property_value: schema "CCTO:000385(time_t t0) = EVENT_STATE(CCTO:000385, t0)" xsd:string ! schema ''Pericarditis''(time_t t0) = EVENT_STATE(''Pericarditis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000386 name: Pulmonary valve disease def: "A heart disorder characterized by a defect in pulmonary valve structure or function OR A disorder characterized by a defect in pulmonary valve function or structure." [NCIT:C78579, NCI:CTCAE] synonym: "Pulmonary valve disorder" EXACT [NCIT:C78579] xref: UMLS:C0034087 xref: NCI:CTCAE:10061541 xref: NCIT:C78579 property_value: ESCORT_rule "CCTO:000386 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pulmonary valve disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000386 implies CCTO:001113" xsd:string ! ESCORT_rule ''Pulmonary valve disease'' implies ''Cardiac disorders'' property_value: schema "CCTO:000386(time_t t0) = EVENT_STATE(CCTO:000386, t0)" xsd:string ! schema ''Pulmonary valve disease''(time_t t0) = EVENT_STATE(''Pulmonary valve disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000387 name: Restrictive cardiomyopathy def: "A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility OR Restrictive cardiomyopathy resulting from a known treatment OR A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium." [NCI:CTCAE, NCIT:C55069, NCIT:C62798] synonym: "Restrictive cardiomyopathy adverse event" EXACT [NCIT:C55069] xref: UMLS:C0007196 xref: UMLS:C1963079 xref: NCI:CTCAE:10038748 xref: NCIT:C55069 xref: NCIT:C62798 property_value: ESCORT_rule "CCTO:000387 implies CCTO:000049" xsd:string ! ESCORT_rule ''Restrictive cardiomyopathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000387 implies CCTO:001113" xsd:string ! ESCORT_rule ''Restrictive cardiomyopathy'' implies ''Cardiac disorders'' property_value: schema "CCTO:000387(time_t t0) = EVENT_STATE(CCTO:000387, t0)" xsd:string ! schema ''Restrictive cardiomyopathy''(time_t t0) = EVENT_STATE(''Restrictive cardiomyopathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000388 name: Right ventricular dysfunction def: "A disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall OR Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall." [NCI:CTCAE, NCIT:C50733] synonym: "Dysfunction, right ventricular" EXACT [NCIT:C50733] xref: UMLS:C0242707 xref: NCI:CTCAE:10058597 xref: NCIT:C50733 property_value: ESCORT_rule "CCTO:000388 implies CCTO:000049" xsd:string ! ESCORT_rule ''Right ventricular dysfunction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000388 implies CCTO:001113" xsd:string ! ESCORT_rule ''Right ventricular dysfunction'' implies ''Cardiac disorders'' property_value: schema "CCTO:000388(time_t t0) = EVENT_STATE(CCTO:000388, t0)" xsd:string ! schema ''Right ventricular dysfunction''(time_t t0) = EVENT_STATE(''Right ventricular dysfunction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000389 name: Sick sinus syndrome def: "A disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness OR A constellation of signs and symptoms which may include syncope, fatigue, dizziness, and alternating periods of bradycardia and atrial tachycardia, which is caused by sinoatrial node dysfunction." [NCI:CTCAE, NCIT:C62244] synonym: "SSS" EXACT [NCIT:C62244] synonym: "Sick sinus syndrome adverse event" EXACT [NCIT:C54938] xref: UMLS:C0037052 xref: UMLS:C1963235 xref: UMLS:C0723181 xref: NCI:CTCAE:10040639 xref: NCIT:C54938 xref: NCIT:C62244 property_value: ESCORT_rule "CCTO:000389 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sick sinus syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000389 implies CCTO:001113" xsd:string ! ESCORT_rule ''Sick sinus syndrome'' implies ''Cardiac disorders'' property_value: schema "CCTO:000389(time_t t0) = EVENT_STATE(CCTO:000389, t0)" xsd:string ! schema ''Sick sinus syndrome''(time_t t0) = EVENT_STATE(''Sick sinus syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000390 name: Sinus bradycardia def: "A disorder characterized by an electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR An electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node." [NCIT:C26923, NCIT:C111097, NCI:CTCAE] synonym: "Sinus bradycardia adverse event" EXACT [NCIT:C54940] synonym: "Sinus Bradycardia by ECG Finding" EXACT [NCIT:C111097] synonym: "Sinus Bradycardia by EKG Finding" EXACT [NCIT:C111097] xref: UMLS:C2108107 xref: UMLS:C1963175 xref: UMLS:C0085610 xref: NCI:CTCAE:10040741 xref: NCIT:C111097 xref: NCIT:C26923 xref: NCIT:C54940 property_value: ESCORT_rule "CCTO:000390 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sinus bradycardia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000390 implies CCTO:001113" xsd:string ! ESCORT_rule ''Sinus bradycardia'' implies ''Cardiac disorders'' property_value: schema "CCTO:000390(time_t t0) = EVENT_STATE(CCTO:000390, t0)" xsd:string ! schema ''Sinus bradycardia''(time_t t0) = EVENT_STATE(''Sinus bradycardia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000391 name: Sinus tachycardia def: "A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node OR A disorder characterized by an electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR An electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC)" [NCI:CTCAE, NCIT:C26889, NCIT:C111104] synonym: "Sinus tachycardia adverse event" EXACT [NCIT:C54941] synonym: "Sinus Tachycardia by ECG Finding" EXACT [NCIT:C111104] synonym: "Sinus Tachycardia by EKG Finding" EXACT [NCIT:C111104] xref: UMLS:C2108109 xref: UMLS:C1963246 xref: UMLS:C0039239 xref: NCI:CTCAE:10040752 xref: NCIT:C111104 xref: NCIT:C26889 xref: NCIT:C54941 property_value: ESCORT_rule "CCTO:000391 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sinus tachycardia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000391 implies CCTO:001113" xsd:string ! ESCORT_rule ''Sinus tachycardia'' implies ''Cardiac disorders'' property_value: schema "CCTO:000391(time_t t0) = EVENT_STATE(CCTO:000391, t0)" xsd:string ! schema ''Sinus tachycardia''(time_t t0) = EVENT_STATE(''Sinus tachycardia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000392 name: Supraventricular tachycardia def: "A disorder characterized by an electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) OR An electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles." [NCIT:C35061, NCIT:C111100, NCI:CTCAE] synonym: "SVT" EXACT [NCIT:C111100] synonym: "SVT" EXACT [NCIT:C35061] synonym: "Supraventricular tachycardia adverse event" EXACT [NCIT:C54945] synonym: "Supraventricular Tachycardia by ECG Finding" EXACT [NCIT:C111100] synonym: "Supraventricular Tachycardia by EKG Finding" EXACT [NCIT:C111100] xref: UMLS:C3815188 xref: UMLS:C0039240 xref: UMLS:C1963244 xref: NCI:CTCAE:10042604 xref: NCIT:C111100 xref: NCIT:C35061 xref: NCIT:C54945 property_value: ESCORT_rule "CCTO:000392 implies CCTO:000049" xsd:string ! ESCORT_rule ''Supraventricular tachycardia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000392 implies CCTO:001113" xsd:string ! ESCORT_rule ''Supraventricular tachycardia'' implies ''Cardiac disorders'' property_value: schema "CCTO:000392(time_t t0) = EVENT_STATE(CCTO:000392, t0)" xsd:string ! schema ''Supraventricular tachycardia''(time_t t0) = EVENT_STATE(''Supraventricular tachycardia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000393 name: Tricuspid valve disease def: "A disorder characterized by a defect in tricuspid valve function or structure OR A heart disorder characterized by a defect in tricuspid valve structure or function." [NCI:CTCAE, NCIT:C78649] synonym: "Tricuspid valve disorder" EXACT [NCIT:C78649] xref: UMLS:C0264882 xref: UMLS:C0264776 xref: NCI:CTCAE:10061389 xref: NCIT:C78649 property_value: ESCORT_rule "CCTO:000393 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tricuspid valve disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000393 implies CCTO:001113" xsd:string ! ESCORT_rule ''Tricuspid valve disease'' implies ''Cardiac disorders'' property_value: schema "CCTO:000393(time_t t0) = EVENT_STATE(CCTO:000393, t0)" xsd:string ! schema ''Tricuspid valve disease''(time_t t0) = EVENT_STATE(''Tricuspid valve disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000394 name: Ventricular arrhythmia def: "An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles OR A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles OR A disorder characterized by a dysrhythmia that originates in the ventricles." [NCIT:C111101, NCIT:C26924, NCI:CTCAE] synonym: "Ventricular arrhythmia adverse event" EXACT [NCIT:C53844] synonym: "Ventricular Arrhythmia by ECG Finding" EXACT [NCIT:C111101] synonym: "Ventricular Arrhythmia by EKG Finding" EXACT [NCIT:C111101] xref: UMLS:C0344424 xref: UMLS:C1883529 xref: UMLS:C0085612 xref: NCI:CTCAE:10047281 xref: NCIT:C111101 xref: NCIT:C26924 xref: NCIT:C53844 property_value: ESCORT_rule "CCTO:000394 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ventricular arrhythmia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000394 implies CCTO:001113" xsd:string ! ESCORT_rule ''Ventricular arrhythmia'' implies ''Cardiac disorders'' property_value: schema "CCTO:000394(time_t t0) = EVENT_STATE(CCTO:000394, t0)" xsd:string ! schema ''Ventricular arrhythmia''(time_t t0) = EVENT_STATE(''Ventricular arrhythmia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000395 name: Ventricular fibrillation def: "A disorder characterized by an electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC) OR A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles OR An electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC)" [NCIT:C50799, NCI:CTCAE, NCIT:C111102] synonym: "Fibrillation, ventricular" EXACT [NCIT:C50799] synonym: "VF" EXACT [NCIT:C111102] synonym: "VF" EXACT [NCIT:C50799] synonym: "VFib" EXACT [NCIT:C111102] synonym: "VFib" EXACT [NCIT:C50799] synonym: "Ventricular fibrillation adverse event" EXACT [NCIT:C54950] synonym: "Ventricular Fibrillation by ECG Finding" EXACT [NCIT:C111102] synonym: "Ventricular Fibrillation by EKG Finding" EXACT [NCIT:C111102] xref: UMLS:C0344435 xref: UMLS:C0042510 xref: UMLS:C1962976 xref: NCI:CTCAE:10047290 xref: NCIT:C111102 xref: NCIT:C50799 xref: NCIT:C54950 property_value: ESCORT_rule "CCTO:000395 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ventricular fibrillation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000395 implies CCTO:001113" xsd:string ! ESCORT_rule ''Ventricular fibrillation'' implies ''Cardiac disorders'' property_value: schema "CCTO:000395(time_t t0) = EVENT_STATE(CCTO:000395, t0)" xsd:string ! schema ''Ventricular fibrillation''(time_t t0) = EVENT_STATE(''Ventricular fibrillation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000396 name: Ventricular tachycardia def: "A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His OR An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)" [NCIT:C50802, NCI:CTCAE, NCIT:C111103] synonym: "Ventricular tachycardia adverse event" EXACT [NCIT:C54951] synonym: "Ventricular Tachycardia by ECG Finding" EXACT [NCIT:C111103] synonym: "Ventricular Tachycardia by EKG Finding" EXACT [NCIT:C111103] xref: UMLS:C0344428 xref: UMLS:C1963247 xref: UMLS:C0042514 xref: NCI:CTCAE:10047302 xref: NCIT:C111103 xref: NCIT:C50802 xref: NCIT:C54951 property_value: ESCORT_rule "CCTO:000396 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ventricular tachycardia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000396 implies CCTO:001113" xsd:string ! ESCORT_rule ''Ventricular tachycardia'' implies ''Cardiac disorders'' property_value: schema "CCTO:000396(time_t t0) = EVENT_STATE(CCTO:000396, t0)" xsd:string ! schema ''Ventricular tachycardia''(time_t t0) = EVENT_STATE(''Ventricular tachycardia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000397 name: Wolff-Parkinson-White syndrome def: "A disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation OR A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes." [NCI:CTCAE, NCIT:C35132] synonym: "WPW" EXACT [NCIT:C35132] synonym: "Wolff-Parkinson-White Syndrome Adverse Event" EXACT [NCIT:C54952] xref: UMLS:C0043202 xref: UMLS:C1963282 xref: NCI:CTCAE:10048015 xref: NCIT:C35132 xref: NCIT:C54952 property_value: ESCORT_rule "CCTO:000397 implies CCTO:000049" xsd:string ! ESCORT_rule ''Wolff-Parkinson-White syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000397 implies CCTO:001113" xsd:string ! ESCORT_rule ''Wolff-Parkinson-White syndrome'' implies ''Cardiac disorders'' property_value: schema "CCTO:000397(time_t t0) = EVENT_STATE(CCTO:000397, t0)" xsd:string ! schema ''Wolff-Parkinson-White syndrome''(time_t t0) = EVENT_STATE(''Wolff-Parkinson-White syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001113 ! Cardiac disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000398 name: Ear pain def: "A disorder characterized by a sensation of marked discomfort in the ear OR Painful sensation in the ear region." [NCI:CTCAE, NCIT:C37944] synonym: "Earache" EXACT [NCIT:C37944] xref: UMLS:C0013456 xref: NCI:CTCAE:10014020 xref: NCIT:C37944 property_value: ESCORT_rule "CCTO:000398 implies CCTO:000107" xsd:string ! ESCORT_rule ''Ear pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000398 implies CCTO:001114" xsd:string ! ESCORT_rule ''Ear pain'' implies ''Ear and labyrinth disorders'' property_value: schema "CCTO:000398(time_t t0) = EVENT_STATE(CCTO:000398, t0)" xsd:string ! schema ''Ear pain''(time_t t0) = EVENT_STATE(''Ear pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001114 ! Ear and labyrinth disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000399 name: External ear inflammation def: "A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage OR Inflammation of the anatomical structures of the outer ear and ear canal, which is most often caused by an infectious process. Symptoms include erythema, edema, and pain OR Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain." [NCI:CTCAE, NCIT:C79601, NCIT:C3299] synonym: "External ear infection" EXACT [NCIT:C3299] synonym: "External otitis" EXACT [NCIT:C79601] synonym: "Infectious otitis externa" EXACT [NCIT:C3299] synonym: "Inflammation of External Auditory Canal" EXACT [NCIT:C79601] synonym: "Inflammation of the External Auditory Canal" EXACT [NCIT:C79601] synonym: "Otitis externa" EXACT [NCIT:C3299] xref: UMLS:C0029878 xref: UMLS:C0021355 xref: UMLS:C0740437 xref: NCI:CTCAE:10033072 xref: NCI:CTCAE:10065837 xref: NCIT:C3299 xref: NCIT:C79601 property_value: ESCORT_rule "CCTO:000399 implies CCTO:000049" xsd:string ! ESCORT_rule ''External ear inflammation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000399 implies CCTO:001114" xsd:string ! ESCORT_rule ''External ear inflammation'' implies ''Ear and labyrinth disorders'' property_value: ESCORT_rule "CCTO:000399 implies CCTO:001119" xsd:string ! ESCORT_rule ''External ear inflammation'' implies ''Infections and infestations'' property_value: schema "CCTO:000399(time_t t0) = EVENT_STATE(CCTO:000399, t0)" xsd:string ! schema ''External ear inflammation''(time_t t0) = EVENT_STATE(''External ear inflammation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001114 ! Ear and labyrinth disorders is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000400 name: External ear pain def: "Painful sensation in the external ear region OR A disorder characterized by a sensation of marked discomfort in the external ear region." [NCIT:C78285, NCI:CTCAE] synonym: "External ear pain adverse event" EXACT [NCIT:C56060] xref: UMLS:C1963108 xref: UMLS:C0239223 xref: NCI:CTCAE:10065785 xref: NCIT:C56060 xref: NCIT:C78285 property_value: ESCORT_rule "CCTO:000400 implies CCTO:000107" xsd:string ! ESCORT_rule ''External ear pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000400 implies CCTO:001114" xsd:string ! ESCORT_rule ''External ear pain'' implies ''Ear and labyrinth disorders'' property_value: schema "CCTO:000400(time_t t0) = EVENT_STATE(CCTO:000400, t0)" xsd:string ! schema ''External ear pain''(time_t t0) = EVENT_STATE(''External ear pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001114 ! Ear and labyrinth disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000401 name: Hearing impaired def: "Partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders." [NCIT:C50576] synonym: "Hearing impairment" EXACT [NCIT:C50576] synonym: "Impairment, hearing" EXACT [NCIT:C50576] xref: UMLS:C1384666 xref: UMLS:C1550444 xref: NCI:CTCAE:10019245 xref: NCIT:C50576 property_value: ESCORT_rule "CCTO:000401 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hearing impaired'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000401 implies CCTO:001114" xsd:string ! ESCORT_rule ''Hearing impaired'' implies ''Ear and labyrinth disorders'' property_value: schema "CCTO:000401(time_t t0) = EVENT_STATE(CCTO:000401, t0)" xsd:string ! schema ''Hearing impaired''(time_t t0) = EVENT_STATE(''Hearing impaired'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001114 ! Ear and labyrinth disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000402 name: Middle ear inflammation def: "Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space OR Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever OR A disorder characterized by an infectious process involving the middle ear." [NCIT:C84354, NCIT:C34885, NCI:CTCAE] synonym: "Infectious otitis media" EXACT [NCIT:C84354] synonym: "Medial otitis" EXACT [NCIT:C34885] synonym: "Middle ear infection" EXACT [NCIT:C84354] synonym: "Otitis media" EXACT [NCIT:C84354] xref: UMLS:C0029882 xref: UMLS:C2827407 xref: NCI:CTCAE:10033078 xref: NCI:CTCAE:10065838 xref: NCIT:C34885 xref: NCIT:C84354 property_value: ESCORT_rule "CCTO:000402 implies CCTO:000049" xsd:string ! ESCORT_rule ''Middle ear inflammation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000402 implies CCTO:001114" xsd:string ! ESCORT_rule ''Middle ear inflammation'' implies ''Ear and labyrinth disorders'' property_value: ESCORT_rule "CCTO:000402 implies CCTO:001119" xsd:string ! ESCORT_rule ''Middle ear inflammation'' implies ''Infections and infestations'' property_value: schema "CCTO:000402(time_t t0) = EVENT_STATE(CCTO:000402, t0)" xsd:string ! schema ''Middle ear inflammation''(time_t t0) = EVENT_STATE(''Middle ear inflammation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001114 ! Ear and labyrinth disorders is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000403 name: Tinnitus def: "Abnormal perception of sounds experienced by an individual in the absence of auditory stimulation OR A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking." [NCIT:C50772, NCI:CTCAE] synonym: "Ears, ringing in" EXACT [NCIT:C50772] synonym: "Ringing in ears" EXACT [NCIT:C50772] synonym: "Tinnitus adverse event" EXACT [NCIT:C54959] synonym: "Tinnitus aurium" EXACT [NCIT:C50772] xref: UMLS:C0040264 xref: UMLS:C1963249 xref: UMLS:C0155533 xref: NCI:CTCAE:10043882 xref: NCIT:C50772 xref: NCIT:C54959 property_value: ESCORT_rule "CCTO:000403 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tinnitus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000403 implies CCTO:001114" xsd:string ! ESCORT_rule ''Tinnitus'' implies ''Ear and labyrinth disorders'' property_value: schema "CCTO:000403(time_t t0) = EVENT_STATE(CCTO:000403, t0)" xsd:string ! schema ''Tinnitus''(time_t t0) = EVENT_STATE(''Tinnitus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001114 ! Ear and labyrinth disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000404 name: Vertigo def: "A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo) OR A feeling of movement, a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). Vertigo is medically distinct from dizziness, lightheadedness, and unsteadiness." [NCI:CTCAE, NCIT:C38057] xref: UMLS:C0042571 xref: UMLS:C1069915 xref: NCI:CTCAE:10047340 xref: NCIT:C38057 property_value: ESCORT_rule "CCTO:000404 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vertigo'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000404 implies CCTO:001114" xsd:string ! ESCORT_rule ''Vertigo'' implies ''Ear and labyrinth disorders'' property_value: schema "CCTO:000404(time_t t0) = EVENT_STATE(CCTO:000404, t0)" xsd:string ! schema ''Vertigo''(time_t t0) = EVENT_STATE(''Vertigo'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001114 ! Ear and labyrinth disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000405 name: Vestibular disorder def: "A disorder characterized by dizziness, imbalance, nausea, and vision problems OR A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems." [NCI:CTCAE, NCIT:C27166] synonym: "Inner ear disorder" EXACT [NCIT:C27166] synonym: "Internal ear disorder" EXACT [NCIT:C27166] xref: UMLS:C0494559 xref: UMLS:C0042594 xref: NCI:CTCAE:10047386 xref: NCIT:C27166 property_value: ESCORT_rule "CCTO:000405 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vestibular disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000405 implies CCTO:001114" xsd:string ! ESCORT_rule ''Vestibular disorder'' implies ''Ear and labyrinth disorders'' property_value: schema "CCTO:000405(time_t t0) = EVENT_STATE(CCTO:000405, t0)" xsd:string ! schema ''Vestibular disorder''(time_t t0) = EVENT_STATE(''Vestibular disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001114 ! Ear and labyrinth disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000406 name: Adrenal insufficiency def: "An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency) OR A disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency." [NCIT:C26691, NCI:CTCAE] synonym: "Adrenal cortical hypofunction" EXACT [NCIT:C26691] synonym: "Adrenal cortical insufficiency" EXACT [NCIT:C26691] synonym: "Adrenal gland insufficiency" EXACT [NCIT:C26691] synonym: "Adrenal insufficiency adverse event" EXACT [NCIT:C55748] synonym: "Adrenocortical insufficiency" EXACT [NCIT:C26691] xref: UMLS:C0405580 xref: UMLS:C0001623 xref: UMLS:C1963059 xref: UMLS:C1417838 xref: NCI:CTCAE:10001367 xref: NCIT:C26691 xref: NCIT:C55748 property_value: ESCORT_rule "CCTO:000406 implies CCTO:000049" xsd:string ! ESCORT_rule ''Adrenal insufficiency'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000406 implies CCTO:001115" xsd:string ! ESCORT_rule ''Adrenal insufficiency'' implies ''Endocrine disorders'' property_value: schema "CCTO:000406(time_t t0) = EVENT_STATE(CCTO:000406, t0)" xsd:string ! schema ''Adrenal insufficiency''(time_t t0) = EVENT_STATE(''Adrenal insufficiency'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000407 name: Cushingoid def: "A constellation of signs and symptoms caused by an excess of glucocorticoids. Classic features include moon facies, buffalo hump, obesity, striae and adiposity OR A disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids." [NCIT:C37938, NCI:CTCAE] xref: UMLS:C0878661 xref: UMLS:C0332601 xref: NCI:CTCAE:10011655 xref: NCIT:C37938 property_value: ESCORT_rule "CCTO:000407 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cushingoid'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000407 implies CCTO:001115" xsd:string ! ESCORT_rule ''Cushingoid'' implies ''Endocrine disorders'' property_value: schema "CCTO:000407(time_t t0) = EVENT_STATE(CCTO:000407, t0)" xsd:string ! schema ''Cushingoid''(time_t t0) = EVENT_STATE(''Cushingoid'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000408 name: Delayed puberty def: "A disorder characterized by unusually late sexual maturity OR Unusually late sexual maturity." [NCI:CTCAE, NCIT:C62587] synonym: "Constitutional growth delay" EXACT [NCIT:C62587] synonym: "Pubertal delay" EXACT [NCIT:C62587] xref: UMLS:C0034012 xref: NCI:CTCAE:10012205 xref: NCIT:C62587 property_value: ESCORT_rule "CCTO:000408 implies CCTO:000049" xsd:string ! ESCORT_rule ''Delayed puberty'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000408 implies CCTO:001115" xsd:string ! ESCORT_rule ''Delayed puberty'' implies ''Endocrine disorders'' property_value: schema "CCTO:000408(time_t t0) = EVENT_STATE(CCTO:000408, t0)" xsd:string ! schema ''Delayed puberty''(time_t t0) = EVENT_STATE(''Delayed puberty'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000409 name: Growth accelerated def: "A finding indicating a faster than normal rate of development OR A disorder characterized by greater growth than expected for age." [NCIT:C83495, NCI:CTCAE] synonym: "Accelerated growth" EXACT [NCIT:C83495] xref: UMLS:C0151685 xref: NCI:CTCAE:10018746 xref: NCIT:C83495 property_value: ESCORT_rule "CCTO:000409 implies CCTO:000049" xsd:string ! ESCORT_rule ''Growth accelerated'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000409 implies CCTO:001115" xsd:string ! ESCORT_rule ''Growth accelerated'' implies ''Endocrine disorders'' property_value: schema "CCTO:000409(time_t t0) = EVENT_STATE(CCTO:000409, t0)" xsd:string ! schema ''Growth accelerated''(time_t t0) = EVENT_STATE(''Growth accelerated'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000410 name: Hyperparathyroidism def: "A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood) OR Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes." [NCI:CTCAE, NCIT:C48259] xref: UMLS:C0020502 xref: NCI:CTCAE:10020705 xref: NCIT:C48259 property_value: ESCORT_rule "CCTO:000410 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperparathyroidism'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000410 implies CCTO:001115" xsd:string ! ESCORT_rule ''Hyperparathyroidism'' implies ''Endocrine disorders'' property_value: schema "CCTO:000410(time_t t0) = EVENT_STATE(CCTO:000410, t0)" xsd:string ! schema ''Hyperparathyroidism''(time_t t0) = EVENT_STATE(''Hyperparathyroidism'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000411 name: Hyperthyroidism def: "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor OR A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose." [NCIT:C3123, NCI:CTCAE] synonym: "Overactive thyroid" EXACT [NCIT:C3123] xref: UMLS:C0020550 xref: NCI:CTCAE:10020850 xref: NCIT:C3123 property_value: ESCORT_rule "CCTO:000411 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperthyroidism'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000411 implies CCTO:001115" xsd:string ! ESCORT_rule ''Hyperthyroidism'' implies ''Endocrine disorders'' property_value: schema "CCTO:000411(time_t t0) = EVENT_STATE(CCTO:000411, t0)" xsd:string ! schema ''Hyperthyroidism''(time_t t0) = EVENT_STATE(''Hyperthyroidism'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000412 name: Hypoparathyroidism def: "An endocrine disorder characterized by decreased production of parathyroid hormone by the parathyroid glands. It is usually caused by damage of the parathyroid glands during head and neck surgery. Signs and symptoms include muscle cramps, abdominal pain, dry skin, brittle nails, cataracts, tetany, and convulsions OR A disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands." [NCIT:C78350, NCI:CTCAE] xref: UMLS:C0020626 xref: NCI:CTCAE:10021041 xref: NCIT:C78350 property_value: ESCORT_rule "CCTO:000412 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypoparathyroidism'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000412 implies CCTO:001115" xsd:string ! ESCORT_rule ''Hypoparathyroidism'' implies ''Endocrine disorders'' property_value: schema "CCTO:000412(time_t t0) = EVENT_STATE(CCTO:000412, t0)" xsd:string ! schema ''Hypoparathyroidism''(time_t t0) = EVENT_STATE(''Hypoparathyroidism'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000413 name: Hypothyroidism def: "A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland OR Abnormally low levels of thyroid hormone." [NCI:CTCAE, NCIT:C26800] synonym: "underactive thyroid" EXACT [NCIT:C26800] xref: UMLS:C0020676 xref: NCI:CTCAE:10021114 xref: NCIT:C26800 property_value: ESCORT_rule "CCTO:000413 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypothyroidism'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000413 implies CCTO:001115" xsd:string ! ESCORT_rule ''Hypothyroidism'' implies ''Endocrine disorders'' property_value: schema "CCTO:000413(time_t t0) = EVENT_STATE(CCTO:000413, t0)" xsd:string ! schema ''Hypothyroidism''(time_t t0) = EVENT_STATE(''Hypothyroidism'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000414 name: Precocious puberty def: "A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys OR Unusually early sexual maturity." [NCI:CTCAE, NCIT:C79704] synonym: "Sexual precocity" EXACT [NCIT:C79704] xref: UMLS:C0034013 xref: UMLS:C0271527 xref: NCI:CTCAE:10058084 xref: NCIT:C79704 property_value: ESCORT_rule "CCTO:000414 implies CCTO:000049" xsd:string ! ESCORT_rule ''Precocious puberty'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000414 implies CCTO:001115" xsd:string ! ESCORT_rule ''Precocious puberty'' implies ''Endocrine disorders'' property_value: schema "CCTO:000414(time_t t0) = EVENT_STATE(CCTO:000414, t0)" xsd:string ! schema ''Precocious puberty''(time_t t0) = EVENT_STATE(''Precocious puberty'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000415 name: Virilization def: "A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male OR The development of normal male puberty due to testosterone effect or the abnormal development of male secondary sexual characteristics in children and females due to excessive androgens OR The abnormal development of male secondary sexual characteristics due to excessive androgens." [NCI:CTCAE, NCIT:C120262, NCIT:C79859] synonym: "Abnormal virilization" EXACT [NCIT:C79859] synonym: "Masculinization" EXACT [NCIT:C79859] synonym: "Virilism" EXACT [NCIT:C79859] xref: UMLS:C0042755 xref: NCI:CTCAE:10047488 xref: NCIT:C120262 xref: NCIT:C79859 property_value: ESCORT_rule "CCTO:000415 implies CCTO:000049" xsd:string ! ESCORT_rule ''Virilization'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000415 implies CCTO:001115" xsd:string ! ESCORT_rule ''Virilization'' implies ''Endocrine disorders'' property_value: schema "CCTO:000415(time_t t0) = EVENT_STATE(CCTO:000415, t0)" xsd:string ! schema ''Virilization''(time_t t0) = EVENT_STATE(''Virilization'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001115 ! Endocrine disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000416 name: Blurred vision def: "Blurred vision is the loss of visual acuity (sharpness of vision) resulting in a loss of ability to see small details. (from MedlinePlus Medical Encyclopedia) OR A disorder characterized by visual perception of unclear or fuzzy images." [NCIT:C27123, NCI:CTCAE] synonym: "Blurring" EXACT [NCIT:C27123] synonym: "Vision, blurring of" EXACT [NCIT:C27123] xref: UMLS:C0344232 xref: NCI:CTCAE:10005886 xref: NCIT:C27123 property_value: ESCORT_rule "CCTO:000416 implies CCTO:000049" xsd:string ! ESCORT_rule ''Blurred vision'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000416 implies CCTO:001116" xsd:string ! ESCORT_rule ''Blurred vision'' implies ''Eye disorders'' property_value: schema "CCTO:000416(time_t t0) = EVENT_STATE(CCTO:000416, t0)" xsd:string ! schema ''Blurred vision''(time_t t0) = EVENT_STATE(''Blurred vision'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000417 name: Cataract def: "A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated OR Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)" [NCI:CTCAE, NCIT:C26713] synonym: "Cataract adverse event" EXACT [NCIT:C55830] synonym: "OPACITY OF THE LENS" EXACT [NCIT:C26713] xref: UMLS:C0086543 xref: UMLS:C1962983 xref: NCI:CTCAE:10007739 xref: NCIT:C26713 xref: NCIT:C55830 property_value: ESCORT_rule "CCTO:000417 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cataract'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000417 implies CCTO:001116" xsd:string ! ESCORT_rule ''Cataract'' implies ''Eye disorders'' property_value: schema "CCTO:000417(time_t t0) = EVENT_STATE(CCTO:000417, t0)" xsd:string ! schema ''Cataract''(time_t t0) = EVENT_STATE(''Cataract'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000418 name: Conjunctivitis def: "A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye OR Inflammation of the conjunctiva of the eye." [NCI:CTCAE, NCIT:C34504] synonym: "Pink eye" EXACT [NCIT:C34504] xref: UMLS:C0009763 xref: UMLS:C1313983 xref: NCI:CTCAE:10010741 xref: NCIT:C34504 property_value: ESCORT_rule "CCTO:000418 implies CCTO:000049" xsd:string ! ESCORT_rule ''Conjunctivitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000418 implies CCTO:001116" xsd:string ! ESCORT_rule ''Conjunctivitis'' implies ''Eye disorders'' property_value: schema "CCTO:000418(time_t t0) = EVENT_STATE(CCTO:000418, t0)" xsd:string ! schema ''Conjunctivitis''(time_t t0) = EVENT_STATE(''Conjunctivitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000419 name: Corneal ulcer def: "Area of epithelial tissue loss from corneal surface; associated with inflammatory cells in the cornea and anterior chamber OR A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber." [NCIT:C50515, NCI:CTCAE] synonym: "Ulcer, corneal" EXACT [NCIT:C50515] xref: UMLS:C0010043 xref: NCI:CTCAE:10048492 xref: NCIT:C50515 property_value: ESCORT_rule "CCTO:000419 implies CCTO:000049" xsd:string ! ESCORT_rule ''Corneal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000419 implies CCTO:001116" xsd:string ! ESCORT_rule ''Corneal ulcer'' implies ''Eye disorders'' property_value: schema "CCTO:000419(time_t t0) = EVENT_STATE(CCTO:000419, t0)" xsd:string ! schema ''Corneal ulcer''(time_t t0) = EVENT_STATE(''Corneal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000420 name: Dry eye def: "A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye OR A disorder characterized by dryness of the cornea and conjunctiva." [NCIT:C34553, NCI:CTCAE] synonym: "Dry eye syndrome" EXACT [NCIT:C34553] synonym: "Dry Eye(s)" EXACT [NCIT:C34553] synonym: "Eye(s), Dry" EXACT [NCIT:C34553] synonym: "Keratoconjunctivitis sicca" EXACT [NCIT:C34553] xref: UMLS:C0314719 xref: UMLS:C0013238 xref: UMLS:C0022575 xref: NCI:CTCAE:10013774 xref: NCIT:C34553 property_value: ESCORT_rule "CCTO:000420 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dry eye'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000420 implies CCTO:001116" xsd:string ! ESCORT_rule ''Dry eye'' implies ''Eye disorders'' property_value: schema "CCTO:000420(time_t t0) = EVENT_STATE(CCTO:000420, t0)" xsd:string ! schema ''Dry eye''(time_t t0) = EVENT_STATE(''Dry eye'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000421 name: Extraocular muscle paresis def: "A slight or incomplete paralysis of an extraocular muscle OR A disorder characterized by incomplete paralysis of an extraocular muscle." [NCIT:C78286, NCI:CTCAE] xref: UMLS:C0262918 xref: NCI:CTCAE:10015829 xref: NCIT:C78286 property_value: ESCORT_rule "CCTO:000421 implies CCTO:000049" xsd:string ! ESCORT_rule ''Extraocular muscle paresis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000421 implies CCTO:001116" xsd:string ! ESCORT_rule ''Extraocular muscle paresis'' implies ''Eye disorders'' property_value: schema "CCTO:000421(time_t t0) = EVENT_STATE(CCTO:000421, t0)" xsd:string ! schema ''Extraocular muscle paresis''(time_t t0) = EVENT_STATE(''Extraocular muscle paresis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000422 name: Eye pain def: "Painful sensation in the eye OR A disorder characterized by a sensation of marked discomfort in the eye." [NCIT:C78287, NCI:CTCAE] synonym: "Eye pain adverse event" EXACT [NCIT:C56070] xref: UMLS:C0151827 xref: UMLS:C1959630 xref: NCI:CTCAE:10015958 xref: NCIT:C56070 xref: NCIT:C78287 property_value: ESCORT_rule "CCTO:000422 implies CCTO:000107" xsd:string ! ESCORT_rule ''Eye pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000422 implies CCTO:001116" xsd:string ! ESCORT_rule ''Eye pain'' implies ''Eye disorders'' property_value: schema "CCTO:000422(time_t t0) = EVENT_STATE(CCTO:000422, t0)" xsd:string ! schema ''Eye pain''(time_t t0) = EVENT_STATE(''Eye pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000423 name: Eyelid function disorder def: "A disorder characterized by impaired eyelid function OR A disorder characterized by impaired eyelid function." [NCI:CTCAE, NCIT:C78288] xref: UMLS:C0854286 xref: NCI:CTCAE:10061145 xref: NCIT:C78288 property_value: ESCORT_rule "CCTO:000423 implies CCTO:000049" xsd:string ! ESCORT_rule ''Eyelid function disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000423 implies CCTO:001116" xsd:string ! ESCORT_rule ''Eyelid function disorder'' implies ''Eye disorders'' property_value: schema "CCTO:000423(time_t t0) = EVENT_STATE(CCTO:000423, t0)" xsd:string ! schema ''Eyelid function disorder''(time_t t0) = EVENT_STATE(''Eyelid function disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000424 name: Flashing lights def: "A disorder characterized by a sudden or brief burst of light OR The perception of sudden or brief bursts (flashes) of light." [NCI:CTCAE, NCIT:C50568] synonym: "Flasher" EXACT [NCIT:C50568] synonym: "Flashers" EXACT [NCIT:C50568] synonym: "Photopsia" EXACT [NCIT:C50568] xref: UMLS:C1705500 xref: UMLS:C0085635 xref: UMLS:C0015269 xref: UMLS:C1705499 xref: NCI:CTCAE:10016757 xref: NCIT:C50568 property_value: ESCORT_rule "CCTO:000424 implies CCTO:000049" xsd:string ! ESCORT_rule ''Flashing lights'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000424 implies CCTO:001116" xsd:string ! ESCORT_rule ''Flashing lights'' implies ''Eye disorders'' property_value: schema "CCTO:000424(time_t t0) = EVENT_STATE(CCTO:000424, t0)" xsd:string ! schema ''Flashing lights''(time_t t0) = EVENT_STATE(''Flashing lights'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000425 name: Floaters def: "Spots before the eyes caused by opaque cell fragments in the vitreous humor or lens OR Spots before the eyes caused by opaque cell fragments in the vitreous humor or lens OR A disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens." [NCIT:C50808, NCIT:C37955, NCI:CTCAE] synonym: "Floaters, vitreous" EXACT [NCIT:C50808] synonym: "Vitreous floater" EXACT [NCIT:C50808] synonym: "Vitreous floaters" EXACT [NCIT:C50808] xref: UMLS:C0016242 xref: NCI:CTCAE:10016778 xref: NCIT:C37955 xref: NCIT:C50808 property_value: ESCORT_rule "CCTO:000425 implies CCTO:000049" xsd:string ! ESCORT_rule ''Floaters'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000425 implies CCTO:001116" xsd:string ! ESCORT_rule ''Floaters'' implies ''Eye disorders'' property_value: schema "CCTO:000425(time_t t0) = EVENT_STATE(CCTO:000425, t0)" xsd:string ! schema ''Floaters''(time_t t0) = EVENT_STATE(''Floaters'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000426 name: Glaucoma def: "A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow OR Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor." [NCI:CTCAE, NCIT:C26782] synonym: "Glaucoma adverse event" EXACT [NCIT:C55842] xref: UMLS:C1962986 xref: UMLS:C0017601 xref: NCI:CTCAE:10018304 xref: NCIT:C26782 xref: NCIT:C55842 property_value: ESCORT_rule "CCTO:000426 implies CCTO:000049" xsd:string ! ESCORT_rule ''Glaucoma'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000426 implies CCTO:001116" xsd:string ! ESCORT_rule ''Glaucoma'' implies ''Eye disorders'' property_value: schema "CCTO:000426(time_t t0) = EVENT_STATE(CCTO:000426, t0)" xsd:string ! schema ''Glaucoma''(time_t t0) = EVENT_STATE(''Glaucoma'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000427 name: Keratitis def: "A disorder characterized by inflammation to the cornea of the eye OR Inflammation of the cornea." [NCI:CTCAE, NCIT:C26805] xref: UMLS:C0022568 xref: NCI:CTCAE:10023332 xref: NCIT:C26805 property_value: ESCORT_rule "CCTO:000427 implies CCTO:000049" xsd:string ! ESCORT_rule ''Keratitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000427 implies CCTO:001116" xsd:string ! ESCORT_rule ''Keratitis'' implies ''Eye disorders'' property_value: schema "CCTO:000427(time_t t0) = EVENT_STATE(CCTO:000427, t0)" xsd:string ! schema ''Keratitis''(time_t t0) = EVENT_STATE(''Keratitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000428 name: Night blindness def: "A disorder characterized by an inability to see clearly in dim light OR An inability to see clearly in dim light; due to a deficiency of vitamin A or to a retinal disorder." [NCI:CTCAE, NCIT:C34850] synonym: "Nyctalopia" EXACT [NCIT:C34850] xref: UMLS:C0028077 xref: NCI:CTCAE:10029404 xref: NCIT:C34850 property_value: ESCORT_rule "CCTO:000428 implies CCTO:000049" xsd:string ! ESCORT_rule ''Night blindness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000428 implies CCTO:001116" xsd:string ! ESCORT_rule ''Night blindness'' implies ''Eye disorders'' property_value: schema "CCTO:000428(time_t t0) = EVENT_STATE(CCTO:000428, t0)" xsd:string ! schema ''Night blindness''(time_t t0) = EVENT_STATE(''Night blindness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000429 name: Optic nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve) OR A disorder characterized by involvement of the optic nerve (second cranial nerve)." [NCIT:C79698, NCI:CTCAE] synonym: "Second cranial nerve disorder" EXACT [NCIT:C79698] xref: UMLS:C0029132 xref: NCI:CTCAE:10061322 xref: NCIT:C79698 property_value: ESCORT_rule "CCTO:000429 implies CCTO:000049" xsd:string ! ESCORT_rule ''Optic nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000429 implies CCTO:001116" xsd:string ! ESCORT_rule ''Optic nerve disorder'' implies ''Eye disorders'' property_value: schema "CCTO:000429(time_t t0) = EVENT_STATE(CCTO:000429, t0)" xsd:string ! schema ''Optic nerve disorder''(time_t t0) = EVENT_STATE(''Optic nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000430 name: Papilledema def: "A disorder characterized by swelling around the optic disc OR Swelling around the optic disc, usually due to increased intracranial pressure or pressure on the optic nerve by a tumor." [NCI:CTCAE, NCIT:C3307] synonym: "Papilloedema" EXACT [NCIT:C3307] xref: UMLS:C0030353 xref: NCI:CTCAE:10033703 xref: NCIT:C3307 property_value: ESCORT_rule "CCTO:000430 implies CCTO:000049" xsd:string ! ESCORT_rule ''Papilledema'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000430 implies CCTO:001116" xsd:string ! ESCORT_rule ''Papilledema'' implies ''Eye disorders'' property_value: schema "CCTO:000430(time_t t0) = EVENT_STATE(CCTO:000430, t0)" xsd:string ! schema ''Papilledema''(time_t t0) = EVENT_STATE(''Papilledema'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000431 name: Photophobia def: "Increased sensitivity of the eyes to light, which can result in the avoidance of light exposure OR A disorder characterized by fear and avoidance of light." [NCIT:C28210, NCI:CTCAE] synonym: "Light sensitivity" EXACT [NCIT:C28210] synonym: "Ocular photosensitivity" EXACT [NCIT:C28210] xref: UMLS:C0085636 xref: NCI:CTCAE:10034960 xref: NCIT:C28210 property_value: ESCORT_rule "CCTO:000431 implies CCTO:000049" xsd:string ! ESCORT_rule ''Photophobia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000431 implies CCTO:001116" xsd:string ! ESCORT_rule ''Photophobia'' implies ''Eye disorders'' property_value: schema "CCTO:000431(time_t t0) = EVENT_STATE(CCTO:000431, t0)" xsd:string ! schema ''Photophobia''(time_t t0) = EVENT_STATE(''Photophobia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000432 name: Retinal detachment def: "A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium OR An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision." [NCI:CTCAE, NCIT:C26874] synonym: "Detached retina" EXACT [NCIT:C26874] synonym: "Retina, detached" EXACT [NCIT:C26874] synonym: "Retinal detachment adverse event" EXACT [NCIT:C55886] xref: UMLS:C0035305 xref: UMLS:C1963229 xref: NCI:CTCAE:10038848 xref: NCIT:C26874 xref: NCIT:C55886 property_value: ESCORT_rule "CCTO:000432 implies CCTO:000049" xsd:string ! ESCORT_rule ''Retinal detachment'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000432 implies CCTO:001116" xsd:string ! ESCORT_rule ''Retinal detachment'' implies ''Eye disorders'' property_value: schema "CCTO:000432(time_t t0) = EVENT_STATE(CCTO:000432, t0)" xsd:string ! schema ''Retinal detachment''(time_t t0) = EVENT_STATE(''Retinal detachment'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000433 name: Retinal tear def: "A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters OR A usually small tearing of the retina occurring when the vitreous separates from the retina. It may lead to retinal detachment. Symptoms include flashes and floaters." [NCI:CTCAE, NCIT:C50732] synonym: "Retina, Tear(s) In" EXACT [NCIT:C50732] synonym: "Retinal tears" EXACT [NCIT:C50732] xref: UMLS:C0035321 xref: NCI:CTCAE:10038897 xref: NCIT:C50732 property_value: ESCORT_rule "CCTO:000433 implies CCTO:000049" xsd:string ! ESCORT_rule ''Retinal tear'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000433 implies CCTO:001116" xsd:string ! ESCORT_rule ''Retinal tear'' implies ''Eye disorders'' property_value: schema "CCTO:000433(time_t t0) = EVENT_STATE(CCTO:000433, t0)" xsd:string ! schema ''Retinal tear''(time_t t0) = EVENT_STATE(''Retinal tear'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000434 name: Retinal vascular disorder def: "Retinal damage resulting from diminished blood flow/oxygenation due to abnormalities of the retinal vessels. Causes include hypertension, diabetes, thrombosis, embolism, and hemorrhage OR A disorder characterized by pathological retinal blood vessels that adversely affects vision." [NCIT:C35170, NCI:CTCAE] xref: UMLS:C0154833 xref: NCI:CTCAE:10038901 xref: NCIT:C35170 property_value: ESCORT_rule "CCTO:000434 implies CCTO:000049" xsd:string ! ESCORT_rule ''Retinal vascular disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000434 implies CCTO:001116" xsd:string ! ESCORT_rule ''Retinal vascular disorder'' implies ''Eye disorders'' property_value: schema "CCTO:000434(time_t t0) = EVENT_STATE(CCTO:000434, t0)" xsd:string ! schema ''Retinal vascular disorder''(time_t t0) = EVENT_STATE(''Retinal vascular disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000435 name: Retinopathy def: "A disorder involving the retina OR Any disease or disorder of the retina." [NCI:CTCAE, NCIT:C62601] synonym: "Retinopathy adverse event" EXACT [NCIT:C55891] xref: UMLS:C0035309 xref: UMLS:C1962966 xref: NCI:CTCAE:10038923 xref: NCIT:C55891 xref: NCIT:C62601 property_value: ESCORT_rule "CCTO:000435 implies CCTO:000049" xsd:string ! ESCORT_rule ''Retinopathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000435 implies CCTO:001116" xsd:string ! ESCORT_rule ''Retinopathy'' implies ''Eye disorders'' property_value: schema "CCTO:000435(time_t t0) = EVENT_STATE(CCTO:000435, t0)" xsd:string ! schema ''Retinopathy''(time_t t0) = EVENT_STATE(''Retinopathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000436 name: Scleral disorder def: "A disorder affecting the sclera. Examples include inflammatory processes (e.g., scleritis and episcleritis), and degenerative processes. Primary tumors of the sclera are extremely rare OR A disorder characterized by involvement of the sclera of the eye." [NCIT:C79717, NCI:CTCAE] synonym: "Sclera disorder" EXACT [NCIT:C79717] xref: UMLS:C0036412 xref: NCI:CTCAE:10061510 xref: NCIT:C79717 property_value: ESCORT_rule "CCTO:000436 implies CCTO:000049" xsd:string ! ESCORT_rule ''Scleral disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000436 implies CCTO:001116" xsd:string ! ESCORT_rule ''Scleral disorder'' implies ''Eye disorders'' property_value: schema "CCTO:000436(time_t t0) = EVENT_STATE(CCTO:000436, t0)" xsd:string ! schema ''Scleral disorder''(time_t t0) = EVENT_STATE(''Scleral disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000437 name: Uveitis def: "An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision OR A disorder characterized by inflammation to the uvea of the eye." [NCIT:C26909, NCI:CTCAE] synonym: "Uveitis adverse event" EXACT [NCIT:C55901] xref: UMLS:C0042164 xref: UMLS:C1963266 xref: NCI:CTCAE:10046851 xref: NCIT:C26909 xref: NCIT:C55901 property_value: ESCORT_rule "CCTO:000437 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uveitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000437 implies CCTO:001116" xsd:string ! ESCORT_rule ''Uveitis'' implies ''Eye disorders'' property_value: schema "CCTO:000437(time_t t0) = EVENT_STATE(CCTO:000437, t0)" xsd:string ! schema ''Uveitis''(time_t t0) = EVENT_STATE(''Uveitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000438 name: Vitreous hemorrhage def: "Blood extravasation in the vitreous humor. Causes include neovascularization, retinal tear, retinal detachment, and rupture of a blood vessel aneurysm in the eye OR A disorder characterized by blood extravasation into the vitreous humor." [NCIT:C50469, NCI:CTCAE] synonym: "Blood in vitreous fluid" EXACT [NCIT:C50469] synonym: "Fluid, blood in vitreous" EXACT [NCIT:C50469] synonym: "Vitreous fluid, blood in" EXACT [NCIT:C50469] synonym: "Vitreous hemorrhage adverse event" EXACT [NCIT:C55921] xref: UMLS:C0042909 xref: UMLS:C1963280 xref: NCI:CTCAE:10047656 xref: NCIT:C50469 xref: NCIT:C55921 property_value: ESCORT_rule "CCTO:000438 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vitreous hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000438 implies CCTO:001116" xsd:string ! ESCORT_rule ''Vitreous hemorrhage'' implies ''Eye disorders'' property_value: schema "CCTO:000438(time_t t0) = EVENT_STATE(CCTO:000438, t0)" xsd:string ! schema ''Vitreous hemorrhage''(time_t t0) = EVENT_STATE(''Vitreous hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000439 name: Watering eyes def: "Tearing eyes; a condition caused either by tear overproduction or impaired drainage of the tear duct. Causes of tear overproduction include eye irritation (e.g., eye infection, foreign body in the eye), headache, pain reaction, allergies, sinusitis, and injury to the eye OR A disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct." [NCIT:C78717, NCI:CTCAE] xref: UMLS:C3257803 xref: UMLS:C0152227 xref: NCI:CTCAE:10047848 xref: NCIT:C78717 property_value: ESCORT_rule "CCTO:000439 implies CCTO:000049" xsd:string ! ESCORT_rule ''Watering eyes'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000439 implies CCTO:001116" xsd:string ! ESCORT_rule ''Watering eyes'' implies ''Eye disorders'' property_value: schema "CCTO:000439(time_t t0) = EVENT_STATE(CCTO:000439, t0)" xsd:string ! schema ''Watering eyes''(time_t t0) = EVENT_STATE(''Watering eyes'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001116 ! Eye disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000440 name: Abdominal distension def: "A disorder characterized by swelling of the abdomen OR Swelling of the abdomen resulting from excessive food intake, malnutrition, liver disease, primary abdominal tumors, and tumors metastatic to the abdominal cavity." [NCI:CTCAE, NCIT:C78161] synonym: "Abdominal bloating" EXACT [NCIT:C78161] synonym: "Abdominal distention" EXACT [NCIT:C78161] xref: UMLS:C0000731 xref: UMLS:C1291077 xref: NCI:CTCAE:10000060 xref: NCIT:C78161 property_value: ESCORT_rule "CCTO:000440 implies CCTO:000049" xsd:string ! ESCORT_rule ''Abdominal distension'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000440 implies CCTO:001108" xsd:string ! ESCORT_rule ''Abdominal distension'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000440(time_t t0) = EVENT_STATE(CCTO:000440, t0)" xsd:string ! schema ''Abdominal distension''(time_t t0) = EVENT_STATE(''Abdominal distension'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000441 name: Abdominal pain def: "A disorder characterized by a sensation of marked discomfort in the abdominal region OR Painful sensation in the abdominal region." [NCI:CTCAE, NCIT:C26682] synonym: "Pain, abdominal" EXACT [NCIT:C26682] xref: UMLS:C0000737 xref: NCI:CTCAE:10000081 xref: NCIT:C26682 property_value: ESCORT_rule "CCTO:000441 implies CCTO:000107" xsd:string ! ESCORT_rule ''Abdominal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000441 implies CCTO:001108" xsd:string ! ESCORT_rule ''Abdominal pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000441(time_t t0) = EVENT_STATE(CCTO:000441, t0)" xsd:string ! schema ''Abdominal pain''(time_t t0) = EVENT_STATE(''Abdominal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000442 name: Anal fistula def: "A disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin OR A pathologic tract that connects an opening in the anal canal to the perianal skin. In the vast majority of cases there is a history of perianal abscess." [NCI:CTCAE, NCIT:C60785] synonym: "Anorectal fistula" EXACT [NCIT:C60785] xref: UMLS:C0149889 xref: UMLS:C0205929 xref: NCI:CTCAE:10002156 xref: NCIT:C60785 property_value: ESCORT_rule "CCTO:000442 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000442 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000442(time_t t0) = EVENT_STATE(CCTO:000442, t0)" xsd:string ! schema ''Anal fistula''(time_t t0) = EVENT_STATE(''Anal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000443 name: Anal hemorrhage def: "A disorder characterized by bleeding from the anal region OR Bleeding originating from the anal area." [NCI:CTCAE, NCIT:C78168] xref: UMLS:C0426747 xref: NCI:CTCAE:10055226 xref: NCIT:C78168 property_value: ESCORT_rule "CCTO:000443 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000443 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000443(time_t t0) = EVENT_STATE(CCTO:000443, t0)" xsd:string ! schema ''Anal hemorrhage''(time_t t0) = EVENT_STATE(''Anal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000444 name: Anal mucositis def: "An inflammatory process affecting the mucous membrane of the anus OR A disorder characterized by inflammation of the mucous membrane of the anus." [NCIT:C78170, NCI:CTCAE] xref: UMLS:C1699653 xref: NCI:CTCAE:10065721 xref: NCIT:C78170 property_value: ESCORT_rule "CCTO:000444 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anal mucositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000444 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal mucositis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000444(time_t t0) = EVENT_STATE(CCTO:000444, t0)" xsd:string ! schema ''Anal mucositis''(time_t t0) = EVENT_STATE(''Anal mucositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000445 name: Anal necrosis def: "A disorder characterized by a necrotic process occurring in the anal region OR A necrotic process involving the area of the anus." [NCI:CTCAE, NCIT:C78171] synonym: "Anal necrotic lesion" EXACT [NCIT:C78171] xref: UMLS:C1697981 xref: NCI:CTCAE:10065722 xref: NCIT:C78171 property_value: ESCORT_rule "CCTO:000445 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anal necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000445 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal necrosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000445(time_t t0) = EVENT_STATE(CCTO:000445, t0)" xsd:string ! schema ''Anal necrosis''(time_t t0) = EVENT_STATE(''Anal necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000446 name: Anal pain def: "A disorder characterized by a sensation of marked discomfort in the anal region OR Painful sensation in the anal region." [NCI:CTCAE, NCIT:C78172] xref: UMLS:C0238637 xref: NCI:CTCAE:10002167 xref: NCIT:C78172 property_value: ESCORT_rule "CCTO:000446 implies CCTO:000107" xsd:string ! ESCORT_rule ''Anal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000446 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000446(time_t t0) = EVENT_STATE(CCTO:000446, t0)" xsd:string ! schema ''Anal pain''(time_t t0) = EVENT_STATE(''Anal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000447 name: Anal stenosis def: "A disorder characterized by a narrowing of the lumen of the anal canal OR Narrowing of the anal canal." [NCI:CTCAE, NCIT:C78173] xref: UMLS:C0262374 xref: NCI:CTCAE:10002176 xref: NCIT:C78173 property_value: ESCORT_rule "CCTO:000447 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000447 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000447(time_t t0) = EVENT_STATE(CCTO:000447, t0)" xsd:string ! schema ''Anal stenosis''(time_t t0) = EVENT_STATE(''Anal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000448 name: Anal ulcer def: "A painful tear in the lining of the anal canal, often accompanied by bleeding on defecation. It is usually the result of a traumatic bowel movement or anal sexual penetration OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal." [NCIT:C79536, NCI:CTCAE] xref: UMLS:C0016167 xref: NCI:CTCAE:10002180 xref: NCIT:C79536 property_value: ESCORT_rule "CCTO:000448 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000448 implies CCTO:001108" xsd:string ! ESCORT_rule ''Anal ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000448(time_t t0) = EVENT_STATE(CCTO:000448, t0)" xsd:string ! schema ''Anal ulcer''(time_t t0) = EVENT_STATE(''Anal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000449 name: Ascites def: "A disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity OR The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum." [NCI:CTCAE, NCIT:C2885] synonym: "INCREASING ABDOMINAL DISTENTION OR ASCITES" EXACT [NCIT:C2885] xref: UMLS:C0003962 xref: NCI:CTCAE:10003445 xref: NCIT:C2885 property_value: ESCORT_rule "CCTO:000449 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ascites'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000449 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ascites'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000449(time_t t0) = EVENT_STATE(CCTO:000449, t0)" xsd:string ! schema ''Ascites''(time_t t0) = EVENT_STATE(''Ascites'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000450 name: Bloating def: "Distention of the abdomen associated with a feeling of fullness OR A disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen." [NCIT:C78213, NCI:CTCAE] xref: UMLS:C1291077 xref: NCI:CTCAE:10005265 xref: NCIT:C78213 property_value: ESCORT_rule "CCTO:000450 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bloating'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000450 implies CCTO:001108" xsd:string ! ESCORT_rule ''Bloating'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000450(time_t t0) = EVENT_STATE(CCTO:000450, t0)" xsd:string ! schema ''Bloating''(time_t t0) = EVENT_STATE(''Bloating'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000451 name: Cecal hemorrhage def: "Bleeding originating in the cecum OR A disorder characterized by bleeding from the cecum." [NCIT:C78234, NCI:CTCAE] xref: UMLS:C1699142 xref: NCI:CTCAE:10065747 xref: NCIT:C78234 property_value: ESCORT_rule "CCTO:000451 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cecal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000451 implies CCTO:001108" xsd:string ! ESCORT_rule ''Cecal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000451(time_t t0) = EVENT_STATE(CCTO:000451, t0)" xsd:string ! schema ''Cecal hemorrhage''(time_t t0) = EVENT_STATE(''Cecal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000452 name: Cheilitis def: "A disorder characterized by inflammation of the lip OR An inflammatory process affecting the lip." [NCI:CTCAE, NCIT:C79545] synonym: "Cheilitis adverse event" EXACT [NCIT:C57901] xref: UMLS:C0007971 xref: UMLS:C1962954 xref: NCI:CTCAE:10008417 xref: NCIT:C57901 xref: NCIT:C79545 property_value: ESCORT_rule "CCTO:000452 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cheilitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000452 implies CCTO:001108" xsd:string ! ESCORT_rule ''Cheilitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000452(time_t t0) = EVENT_STATE(CCTO:000452, t0)" xsd:string ! schema ''Cheilitis''(time_t t0) = EVENT_STATE(''Cheilitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000453 name: Colitis def: "A disorder characterized by inflammation of the colon OR Inflammation of the colon." [NCI:CTCAE, NCIT:C26723] synonym: "Colitis adverse event" EXACT [NCIT:C57134] xref: UMLS:C0009319 xref: UMLS:C1963084 xref: NCI:CTCAE:10009887 xref: NCIT:C26723 xref: NCIT:C57134 property_value: ESCORT_rule "CCTO:000453 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000453 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000453(time_t t0) = EVENT_STATE(CCTO:000453, t0)" xsd:string ! schema ''Colitis''(time_t t0) = EVENT_STATE(''Colitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000454 name: Colonic fistula def: "An abnormal communication between the large intestine and another organ or cavity OR A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site." [NCIT:C78239, NCI:CTCAE] synonym: "Large bowel fistula" EXACT [NCIT:C78239] xref: UMLS:C0341365 xref: UMLS:C0341364 xref: NCI:CTCAE:10009995 xref: NCIT:C78239 property_value: ESCORT_rule "CCTO:000454 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colonic fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000454 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colonic fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000454(time_t t0) = EVENT_STATE(CCTO:000454, t0)" xsd:string ! schema ''Colonic fistula''(time_t t0) = EVENT_STATE(''Colonic fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000455 name: Colonic hemorrhage def: "A disorder characterized by bleeding from the colon OR Bleeding originating from the colon." [NCI:CTCAE, NCIT:C78240] xref: UMLS:C0151694 xref: NCI:CTCAE:10009998 xref: NCIT:C78240 property_value: ESCORT_rule "CCTO:000455 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colonic hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000455 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colonic hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000455(time_t t0) = EVENT_STATE(CCTO:000455, t0)" xsd:string ! schema ''Colonic hemorrhage''(time_t t0) = EVENT_STATE(''Colonic hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000456 name: Colonic obstruction def: "A disorder characterized by blockage of the normal flow of the intestinal contents in the colon OR Blockage of the normal flow of the intestinal contents in the colon." [NCI:CTCAE, NCIT:C78241] xref: UMLS:C0235328 xref: NCI:CTCAE:10010000 xref: NCIT:C78241 property_value: ESCORT_rule "CCTO:000456 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colonic obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000456 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colonic obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000456(time_t t0) = EVENT_STATE(CCTO:000456, t0)" xsd:string ! schema ''Colonic obstruction''(time_t t0) = EVENT_STATE(''Colonic obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000457 name: Colonic perforation def: "A disorder characterized by a rupture in the colonic wall OR A rupture in the colonic wall due to traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78242] xref: UMLS:C0347646 xref: NCI:CTCAE:10010001 xref: NCIT:C78242 property_value: ESCORT_rule "CCTO:000457 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colonic perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000457 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colonic perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000457(time_t t0) = EVENT_STATE(CCTO:000457, t0)" xsd:string ! schema ''Colonic perforation''(time_t t0) = EVENT_STATE(''Colonic perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000458 name: Colonic stenosis def: "Narrowing of the lumen of colon OR A disorder characterized by a narrowing of the lumen of the colon." [NCIT:C78243, NCI:CTCAE] xref: UMLS:C0267466 xref: NCI:CTCAE:10010004 xref: NCIT:C78243 property_value: ESCORT_rule "CCTO:000458 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colonic stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000458 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colonic stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000458(time_t t0) = EVENT_STATE(CCTO:000458, t0)" xsd:string ! schema ''Colonic stenosis''(time_t t0) = EVENT_STATE(''Colonic stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000459 name: Colonic ulcer def: "A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the colon OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon." [NCIT:C78244, NCI:CTCAE] xref: UMLS:C0267491 xref: NCI:CTCAE:10010006 xref: NCIT:C78244 property_value: ESCORT_rule "CCTO:000459 implies CCTO:000049" xsd:string ! ESCORT_rule ''Colonic ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000459 implies CCTO:001108" xsd:string ! ESCORT_rule ''Colonic ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000459(time_t t0) = EVENT_STATE(CCTO:000459, t0)" xsd:string ! schema ''Colonic ulcer''(time_t t0) = EVENT_STATE(''Colonic ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000460 name: Constipation def: "A disorder characterized by irregular and infrequent or difficult evacuation of the bowels OR A question about whether an individual is or has been constipated OR A question about how often an individual has or had constipation OR A question about the usual severity of an individual's constipation OR A question about an individual's distress from their constipation OR Irregular and infrequent or difficult evacuation of the bowels." [NCI:CTCAE, NCIT:C104299, NCIT:C125294, NCIT:C125326, NCIT:C125358, NCIT:C37930] synonym: "Constipation adverse event" EXACT [NCIT:C57141] synonym: "Constipation frequency" EXACT [NCIT:C125294] synonym: "Frequency of Constipation" EXACT [NCIT:C125294] synonym: "Have been constipated" EXACT [NCIT:C104299] synonym: "Have constipation" EXACT [NCIT:C104299] synonym: "Have you been constipated" EXACT [NCIT:C104299] synonym: "How much distress constipation" EXACT [NCIT:C125358] synonym: "How often constipation" EXACT [NCIT:C125294] synonym: "Usual severity constipation" EXACT [NCIT:C125326] xref: UMLS:C0009806 xref: UMLS:C1963087 xref: UMLS:C3641755 xref: NCI:CTCAE:10010774 xref: NCIT:C104299 xref: NCIT:C125294 xref: NCIT:C125326 xref: NCIT:C125358 xref: NCIT:C37930 xref: NCIT:C57141 property_value: ESCORT_rule "CCTO:000460 implies CCTO:000049" xsd:string ! ESCORT_rule ''Constipation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000460 implies CCTO:001108" xsd:string ! ESCORT_rule ''Constipation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000460(time_t t0) = EVENT_STATE(CCTO:000460, t0)" xsd:string ! schema ''Constipation''(time_t t0) = EVENT_STATE(''Constipation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000461 name: Dental caries def: "A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous OR The decay of a tooth, in which it becomes softened, discolored, and/or porous." [NCI:CTCAE, NCIT:C52593] synonym: "Caries" EXACT [NCIT:C52593] synonym: "Cavities" EXACT [NCIT:C52593] synonym: "Tooth decay" EXACT [NCIT:C52593] xref: UMLS:C0011334 xref: NCI:CTCAE:10012318 xref: NCIT:C52593 property_value: ESCORT_rule "CCTO:000461 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dental caries'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000461 implies CCTO:001108" xsd:string ! ESCORT_rule ''Dental caries'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000461(time_t t0) = EVENT_STATE(CCTO:000461, t0)" xsd:string ! schema ''Dental caries''(time_t t0) = EVENT_STATE(''Dental caries'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000462 name: Diarrhea def: "Watery bowel movements OR A question about whether an individual has or had diarrhea OR A disorder characterized by frequent and watery bowel movements OR A question about the usual severity of an individual's diarrhea OR A question about an individual's distress from their diarrhea OR A question about how often an individual has or had diarrhea." [NCIT:C2987, NCIT:C104300, NCI:CTCAE, NCIT:C125312, NCIT:C125344, NCIT:C125280] synonym: "Diarrhea adverse event" EXACT [NCIT:C57788] synonym: "Diarrhea frequency" EXACT [NCIT:C125280] synonym: "Frequency of Diarrhea" EXACT [NCIT:C125280] synonym: "Frequent stools" EXACT [NCIT:C2987] synonym: "Have diarrhea" EXACT [NCIT:C104300] synonym: "Have you had diarrhea" EXACT [NCIT:C104300] synonym: "How much distress diarrhea" EXACT [NCIT:C125344] synonym: "How often diarrhea" EXACT [NCIT:C125280] synonym: "I have diarrhea" EXACT [NCIT:C104300] synonym: "Loose stools" EXACT [NCIT:C2987] synonym: "Usual severity diarrhea" EXACT [NCIT:C125312] xref: UMLS:C3641756 xref: UMLS:C0011991 xref: UMLS:C2129214 xref: UMLS:C0232708 xref: UMLS:C0848342 xref: UMLS:C1963091 xref: NCI:CTCAE:10012727 xref: NCIT:C104300 xref: NCIT:C125280 xref: NCIT:C125312 xref: NCIT:C125344 xref: NCIT:C2987 xref: NCIT:C57788 property_value: ESCORT_rule "CCTO:000462 implies CCTO:000049" xsd:string ! ESCORT_rule ''Diarrhea'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000462 implies CCTO:001108" xsd:string ! ESCORT_rule ''Diarrhea'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000462(time_t t0) = EVENT_STATE(CCTO:000462, t0)" xsd:string ! schema ''Diarrhea''(time_t t0) = EVENT_STATE(''Diarrhea'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000463 name: Dry mouth def: "A question about the usual severity of an individual's dry mouth OR A disorder characterized by reduced salivary flow in the oral cavity OR A question about how often an individual has or had dry mouth OR A question about whether an individual has or had a dry mouth OR A question about an individual's distress from their dry mouth OR Dryness of the oral mucosa secondary to a decrease in saliva production, or a change in saliva composition." [NCIT:C125303, NCI:CTCAE, NCIT:C125270, NCIT:C104937, NCIT:C125335, NCIT:C26917] synonym: "Did you have a dry mouth" EXACT [NCIT:C104937] synonym: "Do you often experience ''dry mouth''" EXACT [NCIT:C104937] synonym: "Dry mouth frequency" EXACT [NCIT:C125270] synonym: "Experience dry mouth" EXACT [NCIT:C104937] synonym: "Frequency of Dry Mouth" EXACT [NCIT:C125270] synonym: "Have dry mouth" EXACT [NCIT:C104937] synonym: "How much distress dry mouth" EXACT [NCIT:C125335] synonym: "How often dry mouth" EXACT [NCIT:C125270] synonym: "My mouth is dry" EXACT [NCIT:C104937] synonym: "Usual severity dry mouth" EXACT [NCIT:C125303] synonym: "Xerostomia" EXACT [NCIT:C26917] xref: UMLS:C0043352 xref: UMLS:C3641895 xref: NCI:CTCAE:10013781 xref: NCIT:C104937 xref: NCIT:C125270 xref: NCIT:C125303 xref: NCIT:C125335 xref: NCIT:C26917 property_value: ESCORT_rule "CCTO:000463 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dry mouth'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000463 implies CCTO:001108" xsd:string ! ESCORT_rule ''Dry mouth'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000463(time_t t0) = EVENT_STATE(CCTO:000463, t0)" xsd:string ! schema ''Dry mouth''(time_t t0) = EVENT_STATE(''Dry mouth'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000464 name: Duodenal fistula def: "A disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site OR An abnormal communication between the duodenum and another organ or cavity." [NCI:CTCAE, NCIT:C78256] xref: UMLS:C0267358 xref: NCI:CTCAE:10013828 xref: NCIT:C78256 property_value: ESCORT_rule "CCTO:000464 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000464 implies CCTO:001108" xsd:string ! ESCORT_rule ''Duodenal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000464(time_t t0) = EVENT_STATE(CCTO:000464, t0)" xsd:string ! schema ''Duodenal fistula''(time_t t0) = EVENT_STATE(''Duodenal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000465 name: Duodenal hemorrhage def: "A disorder characterized by bleeding from the duodenum OR Bleeding originating from the duodenum." [NCI:CTCAE, NCIT:C78257] xref: UMLS:C0521595 xref: NCI:CTCAE:10055242 xref: NCIT:C78257 property_value: ESCORT_rule "CCTO:000465 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000465 implies CCTO:001108" xsd:string ! ESCORT_rule ''Duodenal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000465(time_t t0) = EVENT_STATE(CCTO:000465, t0)" xsd:string ! schema ''Duodenal hemorrhage''(time_t t0) = EVENT_STATE(''Duodenal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000466 name: Duodenal obstruction def: "A disorder characterized by blockage of the normal flow of stomach contents through the duodenum OR Blockage of the normal flow of stomach contents through the duodenum." [NCI:CTCAE, NCIT:C79548] xref: UMLS:C0013292 xref: NCI:CTCAE:10013830 xref: NCIT:C79548 property_value: ESCORT_rule "CCTO:000466 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000466 implies CCTO:001108" xsd:string ! ESCORT_rule ''Duodenal obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000466(time_t t0) = EVENT_STATE(CCTO:000466, t0)" xsd:string ! schema ''Duodenal obstruction''(time_t t0) = EVENT_STATE(''Duodenal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000467 name: Duodenal perforation def: "A rupture in the duodenal wall due to traumatic or pathologic processes OR A disorder characterized by a rupture in the duodenal wall." [NCIT:C78259, NCI:CTCAE] xref: UMLS:C0267356 xref: NCI:CTCAE:10013832 xref: NCIT:C78259 property_value: ESCORT_rule "CCTO:000467 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000467 implies CCTO:001108" xsd:string ! ESCORT_rule ''Duodenal perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000467(time_t t0) = EVENT_STATE(CCTO:000467, t0)" xsd:string ! schema ''Duodenal perforation''(time_t t0) = EVENT_STATE(''Duodenal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000468 name: Duodenal stenosis def: "A disorder characterized by a narrowing of the lumen of the duodenum OR Narrowing of the lumen of the duodenum." [NCI:CTCAE, NCIT:C78260] xref: UMLS:C0238093 xref: NCI:CTCAE:10050094 xref: NCIT:C78260 property_value: ESCORT_rule "CCTO:000468 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000468 implies CCTO:001108" xsd:string ! ESCORT_rule ''Duodenal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000468(time_t t0) = EVENT_STATE(CCTO:000468, t0)" xsd:string ! schema ''Duodenal stenosis''(time_t t0) = EVENT_STATE(''Duodenal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000469 name: Duodenal ulcer def: "A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall OR An ulcer in the duodenal wall." [NCI:CTCAE, NCIT:C26755] xref: UMLS:C0013295 xref: NCI:CTCAE:10013836 xref: NCIT:C26755 property_value: ESCORT_rule "CCTO:000469 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000469 implies CCTO:001108" xsd:string ! ESCORT_rule ''Duodenal ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000469(time_t t0) = EVENT_STATE(CCTO:000469, t0)" xsd:string ! schema ''Duodenal ulcer''(time_t t0) = EVENT_STATE(''Duodenal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000470 name: Dyspepsia def: "An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease OR A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting." [NCIT:C26756, NCI:CTCAE] synonym: "Indigestion" EXACT [NCIT:C26756] xref: UMLS:C0013395 xref: NCI:CTCAE:10013946 xref: NCIT:C26756 property_value: ESCORT_rule "CCTO:000470 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dyspepsia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000470 implies CCTO:001108" xsd:string ! ESCORT_rule ''Dyspepsia'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000470(time_t t0) = EVENT_STATE(CCTO:000470, t0)" xsd:string ! schema ''Dyspepsia''(time_t t0) = EVENT_STATE(''Dyspepsia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000471 name: Dysphagia def: "A symptom referring to difficulty in swallowing. It may be observed in patients with stroke, motor neuron disorders, cancer of the throat or mouth, head and neck injuries, Parkinson disease, and multiple sclerosis OR A disorder characterized by difficulty in swallowing." [NCIT:C2980, NCI:CTCAE] synonym: "Difficulty swallowing" EXACT [NCIT:C2980] xref: UMLS:C0011168 xref: NCI:CTCAE:10013950 xref: NCIT:C2980 property_value: ESCORT_rule "CCTO:000471 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dysphagia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000471 implies CCTO:001108" xsd:string ! ESCORT_rule ''Dysphagia'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000471(time_t t0) = EVENT_STATE(CCTO:000471, t0)" xsd:string ! schema ''Dysphagia''(time_t t0) = EVENT_STATE(''Dysphagia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000472 name: Enterocolitis def: "An inflammatory process affecting the small intestine and colon. Causes include viruses, bacteria, radiation, and antibiotics use OR A disorder characterized by inflammation of the small and large intestines." [NCIT:C79573, NCI:CTCAE] xref: UMLS:C0014356 xref: NCI:CTCAE:10014893 xref: NCIT:C79573 property_value: ESCORT_rule "CCTO:000472 implies CCTO:000049" xsd:string ! ESCORT_rule ''Enterocolitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000472 implies CCTO:001108" xsd:string ! ESCORT_rule ''Enterocolitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000472(time_t t0) = EVENT_STATE(CCTO:000472, t0)" xsd:string ! schema ''Enterocolitis''(time_t t0) = EVENT_STATE(''Enterocolitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000473 name: Enterovesical fistula def: "An abnormal communication between the urinary bladder and the intestine OR A disorder characterized by an abnormal communication between the urinary bladder and the intestine." [NCIT:C78266, NCI:CTCAE] xref: UMLS:C0156272 xref: NCI:CTCAE:10062570 xref: NCIT:C78266 property_value: ESCORT_rule "CCTO:000473 implies CCTO:000049" xsd:string ! ESCORT_rule ''Enterovesical fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000473 implies CCTO:001108" xsd:string ! ESCORT_rule ''Enterovesical fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000473(time_t t0) = EVENT_STATE(CCTO:000473, t0)" xsd:string ! schema ''Enterovesical fistula''(time_t t0) = EVENT_STATE(''Enterovesical fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000474 name: Esophageal fistula def: "An abnormal communication between the esophagus and another organ or anatomic site OR A disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site." [NCIT:C79574, NCI:CTCAE] xref: UMLS:C0014856 xref: NCI:CTCAE:10065851 xref: NCIT:C79574 property_value: ESCORT_rule "CCTO:000474 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000474 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000474(time_t t0) = EVENT_STATE(CCTO:000474, t0)" xsd:string ! schema ''Esophageal fistula''(time_t t0) = EVENT_STATE(''Esophageal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000475 name: Esophageal hemorrhage def: "A disorder characterized by bleeding from the esophagus OR Bleeding originating from the esophagus." [NCI:CTCAE, NCIT:C78271] xref: UMLS:C0239293 xref: NCI:CTCAE:10015384 xref: NCIT:C78271 property_value: ESCORT_rule "CCTO:000475 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000475 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000475(time_t t0) = EVENT_STATE(CCTO:000475, t0)" xsd:string ! schema ''Esophageal hemorrhage''(time_t t0) = EVENT_STATE(''Esophageal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000476 name: Esophageal necrosis def: "A disorder characterized by a necrotic process occurring in the esophageal wall OR A necrotic process involving the esophageal wall." [NCI:CTCAE, NCIT:C78278] synonym: "Esophageal necrotic lesion" EXACT [NCIT:C78278] xref: UMLS:C1697884 xref: NCI:CTCAE:10065727 xref: NCIT:C78278 property_value: ESCORT_rule "CCTO:000476 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000476 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal necrosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000476(time_t t0) = EVENT_STATE(CCTO:000476, t0)" xsd:string ! schema ''Esophageal necrosis''(time_t t0) = EVENT_STATE(''Esophageal necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000477 name: Esophageal obstruction def: "A disorder characterized by blockage of the normal flow of the contents in the esophagus OR Blockage of the normal flow of the contents in the esophagus." [NCI:CTCAE, NCIT:C78279] xref: UMLS:C0239296 xref: NCI:CTCAE:10015387 xref: NCIT:C78279 property_value: ESCORT_rule "CCTO:000477 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000477 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000477(time_t t0) = EVENT_STATE(CCTO:000477, t0)" xsd:string ! schema ''Esophageal obstruction''(time_t t0) = EVENT_STATE(''Esophageal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000478 name: Esophageal pain def: "Painful sensation in the esophageal region OR A disorder characterized by a sensation of marked discomfort in the esophageal region." [NCIT:C78280, NCI:CTCAE] xref: UMLS:C0221727 xref: NCI:CTCAE:10015388 xref: NCIT:C78280 property_value: ESCORT_rule "CCTO:000478 implies CCTO:000107" xsd:string ! ESCORT_rule ''Esophageal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000478 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000478(time_t t0) = EVENT_STATE(CCTO:000478, t0)" xsd:string ! schema ''Esophageal pain''(time_t t0) = EVENT_STATE(''Esophageal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000479 name: Esophageal perforation def: "A disorder characterized by a rupture in the wall of the esophagus OR The presence of a hole or other type of opening in the esophageal wall through which the contents of the esophagus can pass into the mediastinum. The most common cause of esophageal perforation is injury during a medical procedure such as esophagoscopy or placement of a naso-gastric tube; and pathologic process such as neoplasm or gastric reflux with ulceration. Less common causes include injuries from penetrating or blunt trauma or injury to the esophagus during an operation on another organ, mechanical problem such as violent retching or vomiting; ingestion of a foreign body or caustic agents. The condition often results in infection of the mediastinum and mediastinitis." [NCI:CTCAE, NCIT:C50693] synonym: "Esophagus, perforation of" EXACT [NCIT:C50693] synonym: "Perforation of esophagus" EXACT [NCIT:C50693] synonym: "Perforation of Esophagus" EXACT [NCIT:C50693] xref: UMLS:C0014860 xref: NCI:CTCAE:10055472 xref: NCIT:C50693 property_value: ESCORT_rule "CCTO:000479 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000479 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000479(time_t t0) = EVENT_STATE(CCTO:000479, t0)" xsd:string ! schema ''Esophageal perforation''(time_t t0) = EVENT_STATE(''Esophageal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000480 name: Esophageal stenosis def: "A disorder characterized by a narrowing of the lumen of the esophagus OR Narrowing of the lumen of the esophagus." [NCI:CTCAE, NCIT:C34595] synonym: "Esophageal stricture" EXACT [NCIT:C34595] xref: UMLS:C0014866 xref: NCI:CTCAE:10015448 xref: NCIT:C34595 property_value: ESCORT_rule "CCTO:000480 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000480 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000480(time_t t0) = EVENT_STATE(CCTO:000480, t0)" xsd:string ! schema ''Esophageal stenosis''(time_t t0) = EVENT_STATE(''Esophageal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000481 name: Esophageal ulcer def: "A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall OR An ulcerated lesion in the esophageal wall." [NCI:CTCAE, NCIT:C26950] xref: UMLS:C0151970 xref: NCI:CTCAE:10015451 xref: NCIT:C26950 property_value: ESCORT_rule "CCTO:000481 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000481 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000481(time_t t0) = EVENT_STATE(CCTO:000481, t0)" xsd:string ! schema ''Esophageal ulcer''(time_t t0) = EVENT_STATE(''Esophageal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000482 name: Esophageal varices hemorrhage def: "Bleeding from esophageal varices OR A disorder characterized by bleeding from esophageal varices." [NCIT:C78282, NCI:CTCAE] xref: UMLS:C0155789 xref: NCI:CTCAE:10015453 xref: NCIT:C78282 property_value: ESCORT_rule "CCTO:000482 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal varices hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000482 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophageal varices hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000482(time_t t0) = EVENT_STATE(CCTO:000482, t0)" xsd:string ! schema ''Esophageal varices hemorrhage''(time_t t0) = EVENT_STATE(''Esophageal varices hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000483 name: Esophagitis def: "A disorder characterized by inflammation of the esophageal wall OR An acute or chronic inflammatory process affecting the esophageal wall." [NCI:CTCAE, NCIT:C9224] synonym: "Esophagitis adverse event" EXACT [NCIT:C57797] xref: UMLS:C1963106 xref: UMLS:C0014868 xref: NCI:CTCAE:10015461 xref: NCIT:C57797 xref: NCIT:C9224 property_value: ESCORT_rule "CCTO:000483 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophagitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000483 implies CCTO:001108" xsd:string ! ESCORT_rule ''Esophagitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000483(time_t t0) = EVENT_STATE(CCTO:000483, t0)" xsd:string ! schema ''Esophagitis''(time_t t0) = EVENT_STATE(''Esophagitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000484 name: Fecal incontinence def: "A disorder characterized by inability to control the escape of stool from the rectum OR Involuntary passage of stool from the rectum." [NCI:CTCAE, NCIT:C78498] xref: UMLS:C0015732 xref: NCI:CTCAE:10016296 xref: NCIT:C78498 property_value: ESCORT_rule "CCTO:000484 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fecal incontinence'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000484 implies CCTO:001108" xsd:string ! ESCORT_rule ''Fecal incontinence'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000484(time_t t0) = EVENT_STATE(CCTO:000484, t0)" xsd:string ! schema ''Fecal incontinence''(time_t t0) = EVENT_STATE(''Fecal incontinence'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000485 name: Flatulence def: "A disorder characterized by a state of excessive gas in the alimentary canal OR A state of excessive gas in the alimentary canal." [NCI:CTCAE, NCIT:C37954] synonym: "Flatulence adverse event" EXACT [NCIT:C57807] xref: UMLS:C1962956 xref: UMLS:C0016204 xref: NCI:CTCAE:10016766 xref: NCIT:C37954 xref: NCIT:C57807 property_value: ESCORT_rule "CCTO:000485 implies CCTO:000049" xsd:string ! ESCORT_rule ''Flatulence'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000485 implies CCTO:001108" xsd:string ! ESCORT_rule ''Flatulence'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000485(time_t t0) = EVENT_STATE(CCTO:000485, t0)" xsd:string ! schema ''Flatulence''(time_t t0) = EVENT_STATE(''Flatulence'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000486 name: Gastric fistula def: "An abnormal communication between the stomach and another organ or anatomic site OR A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site." [NCIT:C79595, NCI:CTCAE] xref: UMLS:C0017128 xref: NCI:CTCAE:10065713 xref: NCIT:C79595 property_value: ESCORT_rule "CCTO:000486 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000486 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastric fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000486(time_t t0) = EVENT_STATE(CCTO:000486, t0)" xsd:string ! schema ''Gastric fistula''(time_t t0) = EVENT_STATE(''Gastric fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000487 name: Gastric hemorrhage def: "Bleeding from the gastric wall OR A disorder characterized by bleeding from the gastric wall." [NCIT:C54582, NCI:CTCAE] xref: UMLS:C0235325 xref: NCI:CTCAE:10017789 xref: NCIT:C54582 property_value: ESCORT_rule "CCTO:000487 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000487 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastric hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000487(time_t t0) = EVENT_STATE(CCTO:000487, t0)" xsd:string ! schema ''Gastric hemorrhage''(time_t t0) = EVENT_STATE(''Gastric hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000488 name: Gastric necrosis def: "A necrotic process affecting the gastric wall OR A disorder characterized by a necrotic process occurring in the gastric wall." [NCIT:C78314, NCI:CTCAE] synonym: "Gastric necrotic lesion" EXACT [NCIT:C78314] xref: UMLS:C0341221 xref: NCI:CTCAE:10051886 xref: NCIT:C78314 property_value: ESCORT_rule "CCTO:000488 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000488 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastric necrosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000488(time_t t0) = EVENT_STATE(CCTO:000488, t0)" xsd:string ! schema ''Gastric necrosis''(time_t t0) = EVENT_STATE(''Gastric necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000489 name: Gastric perforation def: "A rupture in the gastric wall caused by traumatic or pathologic processes OR A disorder characterized by a rupture in the stomach wall." [NCIT:C78316, NCI:CTCAE] xref: UMLS:C0235884 xref: NCI:CTCAE:10017815 xref: NCIT:C78316 property_value: ESCORT_rule "CCTO:000489 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000489 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastric perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000489(time_t t0) = EVENT_STATE(CCTO:000489, t0)" xsd:string ! schema ''Gastric perforation''(time_t t0) = EVENT_STATE(''Gastric perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000490 name: Gastric stenosis def: "Narrowing of the lumen of the stomach OR A disorder characterized by a narrowing of the lumen of the stomach." [NCIT:C78317, NCI:CTCAE] xref: UMLS:C0585012 xref: NCI:CTCAE:10061970 xref: NCIT:C78317 property_value: ESCORT_rule "CCTO:000490 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000490 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastric stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000490(time_t t0) = EVENT_STATE(CCTO:000490, t0)" xsd:string ! schema ''Gastric stenosis''(time_t t0) = EVENT_STATE(''Gastric stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000491 name: Gastric ulcer def: "An ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach." [NCIT:C3388, NCI:CTCAE] xref: UMLS:C0038358 xref: NCI:CTCAE:10017822 xref: NCIT:C3388 property_value: ESCORT_rule "CCTO:000491 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000491 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastric ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000491(time_t t0) = EVENT_STATE(CCTO:000491, t0)" xsd:string ! schema ''Gastric ulcer''(time_t t0) = EVENT_STATE(''Gastric ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000492 name: Gastritis def: "A disorder characterized by inflammation of the stomach OR Inflammation of the stomach." [NCI:CTCAE, NCIT:C26780] xref: UMLS:C0017152 xref: NCI:CTCAE:10017853 xref: NCIT:C26780 property_value: ESCORT_rule "CCTO:000492 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastritis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000492 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastritis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000492(time_t t0) = EVENT_STATE(CCTO:000492, t0)" xsd:string ! schema ''Gastritis''(time_t t0) = EVENT_STATE(''Gastritis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000493 name: Gastroesophageal reflux disease def: "A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion OR A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa." [NCI:CTCAE, NCIT:C26781] synonym: "GERD" EXACT [NCIT:C26781] xref: UMLS:C0017168 xref: NCI:CTCAE:10066874 xref: NCIT:C26781 property_value: ESCORT_rule "CCTO:000493 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastroesophageal reflux disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000493 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastroesophageal reflux disease'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000493(time_t t0) = EVENT_STATE(CCTO:000493, t0)" xsd:string ! schema ''Gastroesophageal reflux disease''(time_t t0) = EVENT_STATE(''Gastroesophageal reflux disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000494 name: Gastrointestinal fistula def: "A disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site OR An abnormal communication between any part of the digestive system and another organ or cavity." [NCI:CTCAE, NCIT:C78319] synonym: "Digestive system fistula" EXACT [NCIT:C78319] xref: UMLS:C0341212 xref: UMLS:C0079238 xref: NCI:CTCAE:10017877 xref: NCIT:C78319 property_value: ESCORT_rule "CCTO:000494 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastrointestinal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000494 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastrointestinal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000494(time_t t0) = EVENT_STATE(CCTO:000494, t0)" xsd:string ! schema ''Gastrointestinal fistula''(time_t t0) = EVENT_STATE(''Gastrointestinal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000495 name: Gastrointestinal pain def: "A disorder characterized by a sensation of marked discomfort in the gastrointestinal region OR Painful sensation in the gastrointestinal region." [NCI:CTCAE, NCIT:C78320] xref: UMLS:C0687713 xref: NCI:CTCAE:10017999 xref: NCIT:C78320 property_value: ESCORT_rule "CCTO:000495 implies CCTO:000107" xsd:string ! ESCORT_rule ''Gastrointestinal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000495 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastrointestinal pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000495(time_t t0) = EVENT_STATE(CCTO:000495, t0)" xsd:string ! schema ''Gastrointestinal pain''(time_t t0) = EVENT_STATE(''Gastrointestinal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000496 name: Gastroparesis def: "A disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine OR Paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine." [NCI:CTCAE, NCIT:C80512] xref: UMLS:C0152020 xref: NCI:CTCAE:10018043 xref: NCIT:C80512 property_value: ESCORT_rule "CCTO:000496 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastroparesis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000496 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gastroparesis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000496(time_t t0) = EVENT_STATE(CCTO:000496, t0)" xsd:string ! schema ''Gastroparesis''(time_t t0) = EVENT_STATE(''Gastroparesis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000497 name: Gingival pain def: "Painful sensation in the gingival region OR A disorder characterized by a sensation of marked discomfort in the gingival region." [NCIT:C78325, NCI:CTCAE] xref: UMLS:C0239739 xref: NCI:CTCAE:10018286 xref: NCIT:C78325 property_value: ESCORT_rule "CCTO:000497 implies CCTO:000107" xsd:string ! ESCORT_rule ''Gingival pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000497 implies CCTO:001108" xsd:string ! ESCORT_rule ''Gingival pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000497(time_t t0) = EVENT_STATE(CCTO:000497, t0)" xsd:string ! schema ''Gingival pain''(time_t t0) = EVENT_STATE(''Gingival pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000498 name: Hemorrhoidal hemorrhage def: "Bleeding from the hemorrhoids OR A disorder characterized by bleeding from the hemorrhoids." [NCIT:C78337, NCI:CTCAE] xref: UMLS:C0265031 xref: NCI:CTCAE:10060640 xref: NCIT:C78337 property_value: ESCORT_rule "CCTO:000498 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hemorrhoidal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000498 implies CCTO:001108" xsd:string ! ESCORT_rule ''Hemorrhoidal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000498(time_t t0) = EVENT_STATE(CCTO:000498, t0)" xsd:string ! schema ''Hemorrhoidal hemorrhage''(time_t t0) = EVENT_STATE(''Hemorrhoidal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000499 name: Hemorrhoids def: "A disorder characterized by the presence of dilated veins in the rectum and surrounding area OR Dilated veins in the anal canal." [NCI:CTCAE, NCIT:C26792] synonym: "Hemorrhoid" EXACT [NCIT:C26792] synonym: "Hemorrhoids adverse event" EXACT [NCIT:C57819] xref: UMLS:C0019112 xref: UMLS:C1963134 xref: NCI:CTCAE:10019611 xref: NCIT:C26792 xref: NCIT:C57819 property_value: ESCORT_rule "CCTO:000499 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hemorrhoids'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000499 implies CCTO:001108" xsd:string ! ESCORT_rule ''Hemorrhoids'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000499(time_t t0) = EVENT_STATE(CCTO:000499, t0)" xsd:string ! schema ''Hemorrhoids''(time_t t0) = EVENT_STATE(''Hemorrhoids'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000500 name: Ileal fistula def: "A disorder characterized by an abnormal communication between the ileum and another organ or anatomic site OR An abnormal communication between the ileum and another organ or cavity." [NCI:CTCAE, NCIT:C78352] xref: UMLS:C1699655 xref: NCI:CTCAE:10065728 xref: NCIT:C78352 property_value: ESCORT_rule "CCTO:000500 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000500 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000500(time_t t0) = EVENT_STATE(CCTO:000500, t0)" xsd:string ! schema ''Ileal fistula''(time_t t0) = EVENT_STATE(''Ileal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000501 name: Ileal hemorrhage def: "A disorder characterized by bleeding from the ileal wall OR Bleeding originating from the ileal wall." [NCI:CTCAE, NCIT:C78353] xref: UMLS:C0521597 xref: NCI:CTCAE:10055287 xref: NCIT:C78353 property_value: ESCORT_rule "CCTO:000501 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000501 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000501(time_t t0) = EVENT_STATE(CCTO:000501, t0)" xsd:string ! schema ''Ileal hemorrhage''(time_t t0) = EVENT_STATE(''Ileal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000502 name: Ileal obstruction def: "A disorder characterized by blockage of the normal flow of the intestinal contents in the ileum OR Blockage of the normal flow of the small intestinal contents in the ileum." [NCI:CTCAE, NCIT:C78354] xref: UMLS:C1699648 xref: NCI:CTCAE:10065730 xref: NCIT:C78354 property_value: ESCORT_rule "CCTO:000502 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000502 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileal obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000502(time_t t0) = EVENT_STATE(CCTO:000502, t0)" xsd:string ! schema ''Ileal obstruction''(time_t t0) = EVENT_STATE(''Ileal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000503 name: Ileal perforation def: "A rupture in the ileal wall due to traumatic or a pathologic processes OR A disorder characterized by a rupture in the ileal wall." [NCIT:C78355, NCI:CTCAE] synonym: "Perforation of Ileum" EXACT [NCIT:C78355] xref: UMLS:C0559938 xref: NCI:CTCAE:10021305 xref: NCIT:C78355 property_value: ESCORT_rule "CCTO:000503 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000503 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileal perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000503(time_t t0) = EVENT_STATE(CCTO:000503, t0)" xsd:string ! schema ''Ileal perforation''(time_t t0) = EVENT_STATE(''Ileal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000504 name: Ileal stenosis def: "Narrowing of the lumen of ileum OR A disorder characterized by a narrowing of the lumen of the ileum." [NCIT:C78356, NCI:CTCAE] xref: UMLS:C0400847 xref: NCI:CTCAE:10021307 xref: NCIT:C78356 property_value: ESCORT_rule "CCTO:000504 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000504 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000504(time_t t0) = EVENT_STATE(CCTO:000504, t0)" xsd:string ! schema ''Ileal stenosis''(time_t t0) = EVENT_STATE(''Ileal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000505 name: Ileal ulcer def: "A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the ileum OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum." [NCIT:C78357, NCI:CTCAE] xref: UMLS:C0520564 xref: NCI:CTCAE:10021309 xref: NCIT:C78357 property_value: ESCORT_rule "CCTO:000505 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000505 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileal ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000505(time_t t0) = EVENT_STATE(CCTO:000505, t0)" xsd:string ! schema ''Ileal ulcer''(time_t t0) = EVENT_STATE(''Ileal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000506 name: Ileus def: "Decrease in peristalsis in the absence of a mechanical bowel obstruction OR A disorder characterized by failure of the ileum to transport intestinal contents." [NCIT:C37979, NCI:CTCAE] xref: UMLS:C1258215 xref: NCI:CTCAE:10021328 xref: NCIT:C37979 property_value: ESCORT_rule "CCTO:000506 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ileus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000506 implies CCTO:001108" xsd:string ! ESCORT_rule ''Ileus'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000506(time_t t0) = EVENT_STATE(CCTO:000506, t0)" xsd:string ! schema ''Ileus''(time_t t0) = EVENT_STATE(''Ileus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000507 name: Intra-abdominal hemorrhage def: "Bleeding within the abdominal cavity OR A disorder characterized by bleeding in the abdominal cavity." [NCIT:C78372, NCI:CTCAE] xref: UMLS:C0236178 xref: NCI:CTCAE:10055291 xref: NCIT:C78372 property_value: ESCORT_rule "CCTO:000507 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intra-abdominal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000507 implies CCTO:001108" xsd:string ! ESCORT_rule ''Intra-abdominal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000507(time_t t0) = EVENT_STATE(CCTO:000507, t0)" xsd:string ! schema ''Intra-abdominal hemorrhage''(time_t t0) = EVENT_STATE(''Intra-abdominal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000508 name: Jejunal fistula def: "A disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site OR An abnormal communication between the jejunum and another organ or cavity." [NCI:CTCAE, NCIT:C78396] xref: UMLS:C0582253 xref: NCI:CTCAE:10065719 xref: NCIT:C78396 property_value: ESCORT_rule "CCTO:000508 implies CCTO:000049" xsd:string ! ESCORT_rule ''Jejunal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000508 implies CCTO:001108" xsd:string ! ESCORT_rule ''Jejunal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000508(time_t t0) = EVENT_STATE(CCTO:000508, t0)" xsd:string ! schema ''Jejunal fistula''(time_t t0) = EVENT_STATE(''Jejunal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000509 name: Jejunal hemorrhage def: "Bleeding originating from the jejunal wall OR A disorder characterized by bleeding from the jejunal wall." [NCIT:C78397, NCI:CTCAE] xref: UMLS:C0521596 xref: NCI:CTCAE:10055300 xref: NCIT:C78397 property_value: ESCORT_rule "CCTO:000509 implies CCTO:000049" xsd:string ! ESCORT_rule ''Jejunal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000509 implies CCTO:001108" xsd:string ! ESCORT_rule ''Jejunal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000509(time_t t0) = EVENT_STATE(CCTO:000509, t0)" xsd:string ! schema ''Jejunal hemorrhage''(time_t t0) = EVENT_STATE(''Jejunal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000510 name: Jejunal obstruction def: "Blockage of the normal flow of the small intestinal contents in the jejunum OR A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum." [NCIT:C78398, NCI:CTCAE] xref: UMLS:C1699656 xref: NCI:CTCAE:10065732 xref: NCIT:C78398 property_value: ESCORT_rule "CCTO:000510 implies CCTO:000049" xsd:string ! ESCORT_rule ''Jejunal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000510 implies CCTO:001108" xsd:string ! ESCORT_rule ''Jejunal obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000510(time_t t0) = EVENT_STATE(CCTO:000510, t0)" xsd:string ! schema ''Jejunal obstruction''(time_t t0) = EVENT_STATE(''Jejunal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000511 name: Jejunal perforation def: "A disorder characterized by a rupture in the jejunal wall OR A rupture in the jejunal wall due to traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78399] xref: UMLS:C0542147 xref: NCI:CTCAE:10023174 xref: NCIT:C78399 property_value: ESCORT_rule "CCTO:000511 implies CCTO:000049" xsd:string ! ESCORT_rule ''Jejunal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000511 implies CCTO:001108" xsd:string ! ESCORT_rule ''Jejunal perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000511(time_t t0) = EVENT_STATE(CCTO:000511, t0)" xsd:string ! schema ''Jejunal perforation''(time_t t0) = EVENT_STATE(''Jejunal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000512 name: Jejunal stenosis def: "Narrowing of the lumen of jejunum OR A disorder characterized by a narrowing of the lumen of the jejunum." [NCIT:C78400, NCI:CTCAE] xref: UMLS:C0151923 xref: NCI:CTCAE:10023176 xref: NCIT:C78400 property_value: ESCORT_rule "CCTO:000512 implies CCTO:000049" xsd:string ! ESCORT_rule ''Jejunal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000512 implies CCTO:001108" xsd:string ! ESCORT_rule ''Jejunal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000512(time_t t0) = EVENT_STATE(CCTO:000512, t0)" xsd:string ! schema ''Jejunal stenosis''(time_t t0) = EVENT_STATE(''Jejunal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000513 name: Jejunal ulcer def: "A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the jejunum OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum." [NCIT:C78401, NCI:CTCAE] xref: UMLS:C0267489 xref: NCI:CTCAE:10023177 xref: NCIT:C78401 property_value: ESCORT_rule "CCTO:000513 implies CCTO:000049" xsd:string ! ESCORT_rule ''Jejunal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000513 implies CCTO:001108" xsd:string ! ESCORT_rule ''Jejunal ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000513(time_t t0) = EVENT_STATE(CCTO:000513, t0)" xsd:string ! schema ''Jejunal ulcer''(time_t t0) = EVENT_STATE(''Jejunal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000514 name: Lip pain def: "Painful sensation in the lip OR A disorder characterized by a sensation of marked discomfort of the lip." [NCIT:C79684, NCI:CTCAE] synonym: "Lip pain adverse event" EXACT [NCIT:C56110] xref: UMLS:C0267028 xref: UMLS:C1963082 xref: NCI:CTCAE:10024561 xref: NCIT:C56110 xref: NCIT:C79684 property_value: ESCORT_rule "CCTO:000514 implies CCTO:000107" xsd:string ! ESCORT_rule ''Lip pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000514 implies CCTO:001108" xsd:string ! ESCORT_rule ''Lip pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000514(time_t t0) = EVENT_STATE(CCTO:000514, t0)" xsd:string ! schema ''Lip pain''(time_t t0) = EVENT_STATE(''Lip pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000515 name: Lower gastrointestinal hemorrhage def: "Bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus) OR A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus)." [NCIT:C78438, NCI:CTCAE] xref: UMLS:C0024050 xref: NCI:CTCAE:10051746 xref: NCIT:C78438 property_value: ESCORT_rule "CCTO:000515 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lower gastrointestinal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000515 implies CCTO:001108" xsd:string ! ESCORT_rule ''Lower gastrointestinal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000515(time_t t0) = EVENT_STATE(CCTO:000515, t0)" xsd:string ! schema ''Lower gastrointestinal hemorrhage''(time_t t0) = EVENT_STATE(''Lower gastrointestinal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000516 name: Malabsorption def: "A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea OR A disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea OR Inadequate absorption of nutrients in the small intestine." [NCIT:C3214, NCI:CTCAE, NCIT:C113483] synonym: "Malabsorption adverse event" EXACT [NCIT:C57838] synonym: "Malabsorption syndrome" EXACT [NCIT:C3214] xref: UMLS:C0024523 xref: UMLS:C1963165 xref: NCI:CTCAE:10025476 xref: NCIT:C113483 xref: NCIT:C3214 xref: NCIT:C57838 property_value: ESCORT_rule "CCTO:000516 implies CCTO:000049" xsd:string ! ESCORT_rule ''Malabsorption'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000516 implies CCTO:001108" xsd:string ! ESCORT_rule ''Malabsorption'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000516(time_t t0) = EVENT_STATE(CCTO:000516, t0)" xsd:string ! schema ''Malabsorption''(time_t t0) = EVENT_STATE(''Malabsorption'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000517 name: Mucositis oral def: "Inflammation of the oral mucosa due to local or systemic factors OR A disorder characterized by inflammation of the oral mucosal." [NCIT:C26887, NCI:CTCAE] synonym: "Oral mucositis" EXACT [NCIT:C26887] synonym: "Stomatitis" EXACT [NCIT:C26887] xref: UMLS:C0038362 xref: NCI:CTCAE:10028130 xref: NCIT:C26887 property_value: ESCORT_rule "CCTO:000517 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mucositis oral'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000517 implies CCTO:001108" xsd:string ! ESCORT_rule ''Mucositis oral'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000517(time_t t0) = EVENT_STATE(CCTO:000517, t0)" xsd:string ! schema ''Mucositis oral''(time_t t0) = EVENT_STATE(''Mucositis oral'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000518 name: Obstruction gastric def: "A disorder characterized by blockage of the normal flow of the contents in the stomach OR Blockage of the normal flow of the contents in the stomach." [NCI:CTCAE, NCIT:C78505] synonym: "Gastric obstruction" EXACT [NCIT:C78505] xref: UMLS:C0149700 xref: NCI:CTCAE:10029957 xref: NCIT:C78505 property_value: ESCORT_rule "CCTO:000518 implies CCTO:000049" xsd:string ! ESCORT_rule ''Obstruction gastric'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000518 implies CCTO:001108" xsd:string ! ESCORT_rule ''Obstruction gastric'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000518(time_t t0) = EVENT_STATE(CCTO:000518, t0)" xsd:string ! schema ''Obstruction gastric''(time_t t0) = EVENT_STATE(''Obstruction gastric'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000519 name: Oral cavity fistula def: "An abnormal communication between the oral cavity and the adjacent tissues OR A disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site." [NCIT:C78506, NCI:CTCAE] xref: UMLS:C1696083 xref: NCI:CTCAE:10065720 xref: NCIT:C78506 property_value: ESCORT_rule "CCTO:000519 implies CCTO:000049" xsd:string ! ESCORT_rule ''Oral cavity fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000519 implies CCTO:001108" xsd:string ! ESCORT_rule ''Oral cavity fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000519(time_t t0) = EVENT_STATE(CCTO:000519, t0)" xsd:string ! schema ''Oral cavity fistula''(time_t t0) = EVENT_STATE(''Oral cavity fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000520 name: Oral dysesthesia def: "A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth OR A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth." [NCI:CTCAE, NCIT:C62545] synonym: "Burning mouth syndrome" EXACT [NCIT:C62545] xref: UMLS:C0006430 xref: NCI:CTCAE:10054520 xref: NCIT:C62545 xref: NCIT:C78507 property_value: ESCORT_rule "CCTO:000520 implies CCTO:000049" xsd:string ! ESCORT_rule ''Oral dysesthesia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000520 implies CCTO:001108" xsd:string ! ESCORT_rule ''Oral dysesthesia'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000520(time_t t0) = EVENT_STATE(CCTO:000520, t0)" xsd:string ! schema ''Oral dysesthesia''(time_t t0) = EVENT_STATE(''Oral dysesthesia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000521 name: Oral hemorrhage def: "Bleeding originating from the mouth OR A disorder characterized by bleeding from the mouth." [NCIT:C79699, NCI:CTCAE] xref: UMLS:C0029163 xref: NCI:CTCAE:10030980 xref: NCIT:C79699 property_value: ESCORT_rule "CCTO:000521 implies CCTO:000049" xsd:string ! ESCORT_rule ''Oral hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000521 implies CCTO:001108" xsd:string ! ESCORT_rule ''Oral hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000521(time_t t0) = EVENT_STATE(CCTO:000521, t0)" xsd:string ! schema ''Oral hemorrhage''(time_t t0) = EVENT_STATE(''Oral hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000522 name: Oral pain def: "Painful sensation in the mouth, tongue, or lips OR A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips." [NCIT:C78509, NCI:CTCAE] xref: UMLS:C0221776 xref: NCI:CTCAE:10031009 xref: NCIT:C78509 property_value: ESCORT_rule "CCTO:000522 implies CCTO:000107" xsd:string ! ESCORT_rule ''Oral pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000522 implies CCTO:001108" xsd:string ! ESCORT_rule ''Oral pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000522(time_t t0) = EVENT_STATE(CCTO:000522, t0)" xsd:string ! schema ''Oral pain''(time_t t0) = EVENT_STATE(''Oral pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000523 name: Pancreatic duct stenosis def: "Narrowing of the lumen of the pancreatic duct OR A disorder characterized by a narrowing of the lumen of the pancreatic duct." [NCIT:C78519, NCI:CTCAE] xref: UMLS:C0940747 xref: NCI:CTCAE:10065703 xref: NCIT:C78519 property_value: ESCORT_rule "CCTO:000523 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatic duct stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000523 implies CCTO:001108" xsd:string ! ESCORT_rule ''Pancreatic duct stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000523(time_t t0) = EVENT_STATE(CCTO:000523, t0)" xsd:string ! schema ''Pancreatic duct stenosis''(time_t t0) = EVENT_STATE(''Pancreatic duct stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000524 name: Pancreatic fistula def: "A disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site OR An abnormal communication between the pancreas and another organ or cavity." [NCI:CTCAE, NCIT:C79701] xref: UMLS:C0030290 xref: NCI:CTCAE:10049192 xref: NCIT:C79701 property_value: ESCORT_rule "CCTO:000524 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatic fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000524 implies CCTO:001108" xsd:string ! ESCORT_rule ''Pancreatic fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000524(time_t t0) = EVENT_STATE(CCTO:000524, t0)" xsd:string ! schema ''Pancreatic fistula''(time_t t0) = EVENT_STATE(''Pancreatic fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000525 name: Pancreatic hemorrhage def: "Bleeding originating from the pancreas OR A disorder characterized by bleeding from the pancreas." [NCIT:C78521, NCI:CTCAE] xref: UMLS:C0521613 xref: NCI:CTCAE:10033626 xref: NCIT:C78521 property_value: ESCORT_rule "CCTO:000525 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatic hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000525 implies CCTO:001108" xsd:string ! ESCORT_rule ''Pancreatic hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000525(time_t t0) = EVENT_STATE(CCTO:000525, t0)" xsd:string ! schema ''Pancreatic hemorrhage''(time_t t0) = EVENT_STATE(''Pancreatic hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000526 name: Pancreatic necrosis def: "A disorder characterized by a necrotic process occurring in the pancreas OR A necrotic process affecting the pancreas." [NCI:CTCAE, NCIT:C78522] synonym: "Pancreatic necrotic lesion" EXACT [NCIT:C78522] xref: UMLS:C0267953 xref: NCI:CTCAE:10058096 xref: NCIT:C78522 property_value: ESCORT_rule "CCTO:000526 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatic necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000526 implies CCTO:001108" xsd:string ! ESCORT_rule ''Pancreatic necrosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000526(time_t t0) = EVENT_STATE(CCTO:000526, t0)" xsd:string ! schema ''Pancreatic necrosis''(time_t t0) = EVENT_STATE(''Pancreatic necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000527 name: Pancreatitis def: "Inflammation of the pancreas OR A disorder characterized by inflammation of the pancreas." [NCIT:C3306, NCI:CTCAE] synonym: "Pancreatitis adverse event" EXACT [NCIT:C56602] xref: UMLS:C0030305 xref: UMLS:C1963198 xref: NCI:CTCAE:10033645 xref: NCIT:C3306 xref: NCIT:C56602 property_value: ESCORT_rule "CCTO:000527 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000527 implies CCTO:001108" xsd:string ! ESCORT_rule ''Pancreatitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000527(time_t t0) = EVENT_STATE(CCTO:000527, t0)" xsd:string ! schema ''Pancreatitis''(time_t t0) = EVENT_STATE(''Pancreatitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000528 name: Periodontal disease def: "A disorder in the gingival tissue around the teeth OR An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support." [NCI:CTCAE, NCIT:C63743] synonym: "Periodontal disorder" EXACT [NCIT:C63743] xref: UMLS:C0031090 xref: UMLS:C0017563 xref: NCI:CTCAE:10034536 xref: NCIT:C63743 property_value: ESCORT_rule "CCTO:000528 implies CCTO:000049" xsd:string ! ESCORT_rule ''Periodontal disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000528 implies CCTO:001108" xsd:string ! ESCORT_rule ''Periodontal disease'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000528(time_t t0) = EVENT_STATE(CCTO:000528, t0)" xsd:string ! schema ''Periodontal disease''(time_t t0) = EVENT_STATE(''Periodontal disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000529 name: Peritoneal necrosis def: "A necrotic process affecting the peritoneum OR A disorder characterized by a necrotic process occurring in the peritoneum." [NCIT:C78543, NCI:CTCAE] synonym: "Peritoneal necrotic lesion" EXACT [NCIT:C78543] xref: UMLS:C1696082 xref: NCI:CTCAE:10065704 xref: NCIT:C78543 property_value: ESCORT_rule "CCTO:000529 implies CCTO:000049" xsd:string ! ESCORT_rule ''Peritoneal necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000529 implies CCTO:001108" xsd:string ! ESCORT_rule ''Peritoneal necrosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000529(time_t t0) = EVENT_STATE(CCTO:000529, t0)" xsd:string ! schema ''Peritoneal necrosis''(time_t t0) = EVENT_STATE(''Peritoneal necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000530 name: Proctitis def: "A disorder characterized by inflammation of the rectum OR An inflammatory process affecting the anus. It is usually caused by sexually transmitted infectious agents and/or inflammatory bowel disease." [NCI:CTCAE, NCIT:C38011] synonym: "Proctitis adverse event" EXACT [NCIT:C57857] synonym: "rectitis" EXACT [NCIT:C38011] xref: UMLS:C0033246 xref: UMLS:C1963216 xref: NCI:CTCAE:10036774 xref: NCIT:C38011 xref: NCIT:C57857 property_value: ESCORT_rule "CCTO:000530 implies CCTO:000049" xsd:string ! ESCORT_rule ''Proctitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000530 implies CCTO:001108" xsd:string ! ESCORT_rule ''Proctitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000530(time_t t0) = EVENT_STATE(CCTO:000530, t0)" xsd:string ! schema ''Proctitis''(time_t t0) = EVENT_STATE(''Proctitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000531 name: Rectal fistula def: "A disorder characterized by an abnormal communication between the rectum and another organ or anatomic site OR An abnormal communication between the rectum and another organ or cavity." [NCI:CTCAE, NCIT:C79713] xref: UMLS:C0034884 xref: NCI:CTCAE:10038062 xref: NCIT:C79713 property_value: ESCORT_rule "CCTO:000531 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000531 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000531(time_t t0) = EVENT_STATE(CCTO:000531, t0)" xsd:string ! schema ''Rectal fistula''(time_t t0) = EVENT_STATE(''Rectal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000532 name: Rectal hemorrhage def: "A disorder characterized by bleeding from the rectal wall and discharged from the anus OR Bleeding originating from the rectal wall and discharged from the anus." [NCI:CTCAE, NCIT:C27054] xref: UMLS:C0267596 xref: NCI:CTCAE:10038064 xref: NCIT:C27054 property_value: ESCORT_rule "CCTO:000532 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000532 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000532(time_t t0) = EVENT_STATE(CCTO:000532, t0)" xsd:string ! schema ''Rectal hemorrhage''(time_t t0) = EVENT_STATE(''Rectal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000533 name: Rectal mucositis def: "An inflammatory process affecting the mucous membrane of the rectum OR A disorder characterized by inflammation of the mucous membrane of the rectum." [NCIT:C78584, NCI:CTCAE] xref: UMLS:C1328588 xref: NCI:CTCAE:10063190 xref: NCIT:C78584 property_value: ESCORT_rule "CCTO:000533 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal mucositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000533 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal mucositis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000533(time_t t0) = EVENT_STATE(CCTO:000533, t0)" xsd:string ! schema ''Rectal mucositis''(time_t t0) = EVENT_STATE(''Rectal mucositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000534 name: Rectal necrosis def: "A disorder characterized by a necrotic process occurring in the rectal wall OR A necrotic process involving the rectal wall." [NCI:CTCAE, NCIT:C78585] synonym: "Rectal necrotic lesion" EXACT [NCIT:C78585] xref: UMLS:C1697980 xref: NCI:CTCAE:10065709 xref: NCIT:C78585 property_value: ESCORT_rule "CCTO:000534 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000534 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal necrosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000534(time_t t0) = EVENT_STATE(CCTO:000534, t0)" xsd:string ! schema ''Rectal necrosis''(time_t t0) = EVENT_STATE(''Rectal necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000535 name: Rectal obstruction def: "A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum OR Blockage of the normal flow of the intestinal contents in the rectum." [NCI:CTCAE, NCIT:C78586] xref: UMLS:C1697746 xref: NCI:CTCAE:10065707 xref: NCIT:C78586 property_value: ESCORT_rule "CCTO:000535 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000535 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000535(time_t t0) = EVENT_STATE(CCTO:000535, t0)" xsd:string ! schema ''Rectal obstruction''(time_t t0) = EVENT_STATE(''Rectal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000536 name: Rectal pain def: "Pain in the rectal area OR A disorder characterized by a sensation of marked discomfort in the rectal region." [NCIT:C78587, NCI:CTCAE] xref: UMLS:C0034886 xref: NCI:CTCAE:10038072 xref: NCIT:C78587 property_value: ESCORT_rule "CCTO:000536 implies CCTO:000107" xsd:string ! ESCORT_rule ''Rectal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000536 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000536(time_t t0) = EVENT_STATE(CCTO:000536, t0)" xsd:string ! schema ''Rectal pain''(time_t t0) = EVENT_STATE(''Rectal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000537 name: Rectal perforation def: "A disorder characterized by a rupture in the rectal wall OR An rupture in the rectal wall due to traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78588] xref: UMLS:C0341402 xref: NCI:CTCAE:10038073 xref: NCIT:C78588 property_value: ESCORT_rule "CCTO:000537 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000537 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000537(time_t t0) = EVENT_STATE(CCTO:000537, t0)" xsd:string ! schema ''Rectal perforation''(time_t t0) = EVENT_STATE(''Rectal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000538 name: Rectal stenosis def: "Narrowing of the rectal lumen OR A disorder characterized by a narrowing of the lumen of the rectum." [NCIT:C78589, NCI:CTCAE] xref: UMLS:C0267581 xref: NCI:CTCAE:10038079 xref: NCIT:C78589 property_value: ESCORT_rule "CCTO:000538 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000538 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000538(time_t t0) = EVENT_STATE(CCTO:000538, t0)" xsd:string ! schema ''Rectal stenosis''(time_t t0) = EVENT_STATE(''Rectal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000539 name: Rectal ulcer def: "A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum OR A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the rectum." [NCI:CTCAE, NCIT:C78590] xref: UMLS:C0400839 xref: NCI:CTCAE:10038080 xref: NCIT:C78590 property_value: ESCORT_rule "CCTO:000539 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000539 implies CCTO:001108" xsd:string ! ESCORT_rule ''Rectal ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000539(time_t t0) = EVENT_STATE(CCTO:000539, t0)" xsd:string ! schema ''Rectal ulcer''(time_t t0) = EVENT_STATE(''Rectal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000540 name: Retroperitoneal hemorrhage def: "Bleeding originating in the retroperitoneal area OR A disorder characterized by bleeding from the retroperitoneal area." [NCIT:C26944, NCI:CTCAE] xref: UMLS:C0151705 xref: NCI:CTCAE:10038981 xref: NCIT:C26944 property_value: ESCORT_rule "CCTO:000540 implies CCTO:000049" xsd:string ! ESCORT_rule ''Retroperitoneal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000540 implies CCTO:001108" xsd:string ! ESCORT_rule ''Retroperitoneal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000540(time_t t0) = EVENT_STATE(CCTO:000540, t0)" xsd:string ! schema ''Retroperitoneal hemorrhage''(time_t t0) = EVENT_STATE(''Retroperitoneal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000541 name: Salivary duct inflammation def: "An inflammatory process affecting the salivary duct OR A disorder characterized by inflammation of the salivary duct." [NCIT:C78600, NCI:CTCAE] xref: UMLS:C1112516 xref: NCI:CTCAE:10056681 xref: NCIT:C78600 property_value: ESCORT_rule "CCTO:000541 implies CCTO:000049" xsd:string ! ESCORT_rule ''Salivary duct inflammation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000541 implies CCTO:001108" xsd:string ! ESCORT_rule ''Salivary duct inflammation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000541(time_t t0) = EVENT_STATE(CCTO:000541, t0)" xsd:string ! schema ''Salivary duct inflammation''(time_t t0) = EVENT_STATE(''Salivary duct inflammation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000542 name: Salivary gland fistula def: "An abnormal communication between a salivary gland and another organ or anatomic site OR A disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site." [NCIT:C79715, NCI:CTCAE] synonym: "Salivary gland fistula adverse event" EXACT [NCIT:C57868] xref: UMLS:C2700637 xref: UMLS:C0036094 xref: NCI:CTCAE:10039411 xref: NCIT:C57868 xref: NCIT:C79715 property_value: ESCORT_rule "CCTO:000542 implies CCTO:000049" xsd:string ! ESCORT_rule ''Salivary gland fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000542 implies CCTO:001108" xsd:string ! ESCORT_rule ''Salivary gland fistula'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000542(time_t t0) = EVENT_STATE(CCTO:000542, t0)" xsd:string ! schema ''Salivary gland fistula''(time_t t0) = EVENT_STATE(''Salivary gland fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000543 name: Small intestinal mucositis def: "An inflammatory process affecting the mucous membrane of the small intestine OR A disorder characterized by inflammation of the mucous membrane of the small intestine." [NCIT:C78613, NCI:CTCAE] xref: UMLS:C1698626 xref: NCI:CTCAE:10065710 xref: NCIT:C78613 property_value: ESCORT_rule "CCTO:000543 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestinal mucositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000543 implies CCTO:001108" xsd:string ! ESCORT_rule ''Small intestinal mucositis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000543(time_t t0) = EVENT_STATE(CCTO:000543, t0)" xsd:string ! schema ''Small intestinal mucositis''(time_t t0) = EVENT_STATE(''Small intestinal mucositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000544 name: Small intestinal obstruction def: "Blockage of the normal flow of the small intestinal contents OR A disorder characterized by blockage of the normal flow of the intestinal contents." [NCIT:C78615, NCI:CTCAE] xref: UMLS:C0235329 xref: NCI:CTCAE:10041101 xref: NCIT:C78615 property_value: ESCORT_rule "CCTO:000544 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestinal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000544 implies CCTO:001108" xsd:string ! ESCORT_rule ''Small intestinal obstruction'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000544(time_t t0) = EVENT_STATE(CCTO:000544, t0)" xsd:string ! schema ''Small intestinal obstruction''(time_t t0) = EVENT_STATE(''Small intestinal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000545 name: Small intestinal perforation def: "A rupture in the wall of the small intestine due to traumatic or pathologic processes OR A disorder characterized by a rupture in the small intestine wall." [NCIT:C78616, NCI:CTCAE] xref: UMLS:C0151739 xref: NCI:CTCAE:10041103 xref: NCIT:C78616 property_value: ESCORT_rule "CCTO:000545 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestinal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000545 implies CCTO:001108" xsd:string ! ESCORT_rule ''Small intestinal perforation'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000545(time_t t0) = EVENT_STATE(CCTO:000545, t0)" xsd:string ! schema ''Small intestinal perforation''(time_t t0) = EVENT_STATE(''Small intestinal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000546 name: Small intestinal stenosis def: "A disorder characterized by a narrowing of the lumen of the small intestine OR Narrowing of the lumen of small intestine." [NCI:CTCAE, NCIT:C78617] xref: UMLS:C0151924 xref: NCI:CTCAE:10062263 xref: NCIT:C78617 property_value: ESCORT_rule "CCTO:000546 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestinal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000546 implies CCTO:001108" xsd:string ! ESCORT_rule ''Small intestinal stenosis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000546(time_t t0) = EVENT_STATE(CCTO:000546, t0)" xsd:string ! schema ''Small intestinal stenosis''(time_t t0) = EVENT_STATE(''Small intestinal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000547 name: Small intestine ulcer def: "A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine OR A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the small intestine." [NCI:CTCAE, NCIT:C78619] synonym: "Small intestinal ulcer" EXACT [NCIT:C78619] xref: UMLS:C0151977 xref: NCI:CTCAE:10041133 xref: NCIT:C78619 property_value: ESCORT_rule "CCTO:000547 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestine ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000547 implies CCTO:001108" xsd:string ! ESCORT_rule ''Small intestine ulcer'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000547(time_t t0) = EVENT_STATE(CCTO:000547, t0)" xsd:string ! schema ''Small intestine ulcer''(time_t t0) = EVENT_STATE(''Small intestine ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000548 name: Stomach pain def: "A disorder characterized by a sensation of marked discomfort in the stomach OR A painful sensation in the stomach." [NCI:CTCAE, NCIT:C78630] synonym: "Gastric pain" EXACT [NCIT:C78630] synonym: "Stomach pain adverse event" EXACT [NCIT:C56230] xref: UMLS:C0221512 xref: UMLS:C1963242 xref: NCI:CTCAE:10042112 xref: NCIT:C56230 xref: NCIT:C78630 property_value: ESCORT_rule "CCTO:000548 implies CCTO:000107" xsd:string ! ESCORT_rule ''Stomach pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000548 implies CCTO:001108" xsd:string ! ESCORT_rule ''Stomach pain'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000548(time_t t0) = EVENT_STATE(CCTO:000548, t0)" xsd:string ! schema ''Stomach pain''(time_t t0) = EVENT_STATE(''Stomach pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000549 name: Tooth development disorder def: "A disorder characterized by a pathological process of the teeth occurring during tooth development OR A disorder of the teeth arising during odontogenesis." [NCI:CTCAE, NCIT:C35596] synonym: "Dental developmental disorder" EXACT [NCIT:C35596] xref: UMLS:C0494698 xref: NCI:CTCAE:10044030 xref: NCIT:C35596 property_value: ESCORT_rule "CCTO:000549 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tooth development disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000549 implies CCTO:001108" xsd:string ! ESCORT_rule ''Tooth development disorder'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000549(time_t t0) = EVENT_STATE(CCTO:000549, t0)" xsd:string ! schema ''Tooth development disorder''(time_t t0) = EVENT_STATE(''Tooth development disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000550 name: Tooth discoloration def: "A change in tooth color. Causes may be local or systemic and include tobacco use, foods, dental plaques, caries, restorative filling materials, trauma, medications, infections, hereditary diseases, and nutritional deficiencies OR A disorder characterized by a change in tooth hue or tint." [NCIT:C80112, NCI:CTCAE] xref: UMLS:C0040434 xref: NCI:CTCAE:10044031 xref: NCIT:C80112 property_value: ESCORT_rule "CCTO:000550 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tooth discoloration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000550 implies CCTO:001108" xsd:string ! ESCORT_rule ''Tooth discoloration'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000550(time_t t0) = EVENT_STATE(CCTO:000550, t0)" xsd:string ! schema ''Tooth discoloration''(time_t t0) = EVENT_STATE(''Tooth discoloration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000551 name: Toothache def: "A disorder characterized by a sensation of marked discomfort in the tooth OR A painful sensation originating from a tooth." [NCI:CTCAE, NCIT:C78640] xref: UMLS:C0040460 xref: NCI:CTCAE:10044055 xref: NCIT:C78640 property_value: ESCORT_rule "CCTO:000551 implies CCTO:000049" xsd:string ! ESCORT_rule ''Toothache'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000551 implies CCTO:001108" xsd:string ! ESCORT_rule ''Toothache'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000551(time_t t0) = EVENT_STATE(CCTO:000551, t0)" xsd:string ! schema ''Toothache''(time_t t0) = EVENT_STATE(''Toothache'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000552 name: Typhlitis def: "Inflammation of the cecum, usually accompanied by neutropenia OR A disorder characterized by inflammation of the cecum." [NCIT:C38043, NCI:CTCAE] synonym: "Neutropenic colitis" EXACT [NCIT:C38043] xref: UMLS:C0267537 xref: UMLS:C0400823 xref: NCI:CTCAE:10045271 xref: NCIT:C38043 property_value: ESCORT_rule "CCTO:000552 implies CCTO:000049" xsd:string ! ESCORT_rule ''Typhlitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000552 implies CCTO:001108" xsd:string ! ESCORT_rule ''Typhlitis'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000552(time_t t0) = EVENT_STATE(CCTO:000552, t0)" xsd:string ! schema ''Typhlitis''(time_t t0) = EVENT_STATE(''Typhlitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000553 name: Upper gastrointestinal hemorrhage def: "A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach) OR Bleeding originating from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach)." [NCI:CTCAE, NCIT:C78660] xref: UMLS:C0041909 xref: NCI:CTCAE:10055356 xref: NCIT:C78660 property_value: ESCORT_rule "CCTO:000553 implies CCTO:000049" xsd:string ! ESCORT_rule ''Upper gastrointestinal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000553 implies CCTO:001108" xsd:string ! ESCORT_rule ''Upper gastrointestinal hemorrhage'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000553(time_t t0) = EVENT_STATE(CCTO:000553, t0)" xsd:string ! schema ''Upper gastrointestinal hemorrhage''(time_t t0) = EVENT_STATE(''Upper gastrointestinal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000554 name: Vomiting def: "A question about whether an individual has been vomiting OR A question about an individual's distress from their vomiting OR A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth OR A question about whether an individual is or was bothered by vomiting OR A question about the usual severity of an individual's vomiting OR A question about how often an individual vomits or vomited OR Forceful ejection of the contents of the stomach through the mouth." [NCIT:C115346, NCIT:C125342, NCI:CTCAE, NCIT:C125647, NCIT:C125310, NCIT:C125278, NCIT:C3442] synonym: "Bothered by Vomiting" EXACT [NCIT:C125647] synonym: "Emesis" EXACT [NCIT:C3442] synonym: "Frequency of Vomiting" EXACT [NCIT:C125278] synonym: "Have been vomiting" EXACT [NCIT:C115346] synonym: "How much distress vomiting" EXACT [NCIT:C125342] synonym: "How often vomiting" EXACT [NCIT:C125278] synonym: "I have been vomiting" EXACT [NCIT:C115346] synonym: "Usual severity vomiting" EXACT [NCIT:C125310] synonym: "Vomiting adverse event" EXACT [NCIT:C57896] synonym: "Vomiting frequency" EXACT [NCIT:C125278] synonym: "vomit" EXACT [NCIT:C3442] xref: UMLS:C0042963 xref: UMLS:C0042965 xref: UMLS:C1963281 xref: NCI:CTCAE:10047700 xref: NCIT:C115346 xref: NCIT:C125278 xref: NCIT:C125310 xref: NCIT:C125342 xref: NCIT:C125647 xref: NCIT:C3442 xref: NCIT:C57896 property_value: ESCORT_rule "CCTO:000554 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vomiting'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000554 implies CCTO:001108" xsd:string ! ESCORT_rule ''Vomiting'' implies ''Gastrointestinal disorders'' property_value: schema "CCTO:000554(time_t t0) = EVENT_STATE(CCTO:000554, t0)" xsd:string ! schema ''Vomiting''(time_t t0) = EVENT_STATE(''Vomiting'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001108 ! Gastrointestinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000555 name: Chills def: "Shivering or moderate tremors of the body often accompanied by a cold sensation OR A disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever." [NCIT:C35143, NCI:CTCAE] synonym: "Chill" EXACT [NCIT:C35143] xref: UMLS:C0085593 xref: NCI:CTCAE:10008531 xref: NCIT:C35143 property_value: ESCORT_rule "CCTO:000555 implies CCTO:000049" xsd:string ! ESCORT_rule ''Chills'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000555 implies CCTO:001103" xsd:string ! ESCORT_rule ''Chills'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000555(time_t t0) = EVENT_STATE(CCTO:000555, t0)" xsd:string ! schema ''Chills''(time_t t0) = EVENT_STATE(''Chills'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000556 name: Death neonatal def: "A disorder characterized by cessation of life occurring during the first 28 days of life OR Death of a live newborn during the first 28 days of life." [NCI:CTCAE, NCIT:C80082] synonym: "Neonatal death" EXACT [NCIT:C80082] xref: UMLS:C0410916 xref: NCI:CTCAE:10011912 xref: NCIT:C80082 property_value: ESCORT_rule "CCTO:000556 implies CCTO:000049" xsd:string ! ESCORT_rule ''Death neonatal'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000556 implies CCTO:001103" xsd:string ! ESCORT_rule ''Death neonatal'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000556(time_t t0) = EVENT_STATE(CCTO:000556, t0)" xsd:string ! schema ''Death neonatal''(time_t t0) = EVENT_STATE(''Death neonatal'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000557 name: Edema face def: "Swelling due to an excessive accumulation of fluid in facial tissues OR A disorder characterized by swelling due to excessive fluid accumulation in facial tissues." [NCIT:C78289, NCI:CTCAE] synonym: "Face edema" EXACT [NCIT:C78289] xref: UMLS:C0542571 xref: NCI:CTCAE:10014222 xref: NCIT:C78289 property_value: ESCORT_rule "CCTO:000557 implies CCTO:000049" xsd:string ! ESCORT_rule ''Edema face'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000557 implies CCTO:001103" xsd:string ! ESCORT_rule ''Edema face'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000557(time_t t0) = EVENT_STATE(CCTO:000557, t0)" xsd:string ! schema ''Edema face''(time_t t0) = EVENT_STATE(''Edema face'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000558 name: Edema limbs def: "A disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities OR Swelling due to an excessive accumulation of fluid in the upper or lower extremities." [NCI:CTCAE, NCIT:C78262] synonym: "Limbs edema" EXACT [NCIT:C78262] synonym: "Peripheral edema" EXACT [NCIT:C78262] xref: UMLS:C0085649 xref: NCI:CTCAE:10050068 xref: NCIT:C78262 property_value: ESCORT_rule "CCTO:000558 implies CCTO:000049" xsd:string ! ESCORT_rule ''Edema limbs'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000558 implies CCTO:001103" xsd:string ! ESCORT_rule ''Edema limbs'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000558(time_t t0) = EVENT_STATE(CCTO:000558, t0)" xsd:string ! schema ''Edema limbs''(time_t t0) = EVENT_STATE(''Edema limbs'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000559 name: Edema trunk def: "Swelling due to an excessive accumulation of fluid in trunk area OR A disorder characterized by swelling due to excessive fluid accumulation in the trunk area." [NCIT:C78263, NCI:CTCAE] xref: UMLS:C0578541 xref: NCI:CTCAE:10058720 xref: NCIT:C78263 property_value: ESCORT_rule "CCTO:000559 implies CCTO:000049" xsd:string ! ESCORT_rule ''Edema trunk'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000559 implies CCTO:001103" xsd:string ! ESCORT_rule ''Edema trunk'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000559(time_t t0) = EVENT_STATE(CCTO:000559, t0)" xsd:string ! schema ''Edema trunk''(time_t t0) = EVENT_STATE(''Edema trunk'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000560 name: Facial pain def: "Painful sensation in the face OR A disorder characterized by a sensation of marked discomfort in the face." [NCIT:C79594, NCI:CTCAE] xref: UMLS:C0015468 xref: NCI:CTCAE:10016059 xref: NCIT:C79594 property_value: ESCORT_rule "CCTO:000560 implies CCTO:000107" xsd:string ! ESCORT_rule ''Facial pain'' implies ''Pain'' property_value: schema "CCTO:000560(time_t t0) = EVENT_STATE(CCTO:000560, t0)" xsd:string ! schema ''Facial pain''(time_t t0) = EVENT_STATE(''Facial pain'', t0) is_a: CCTO:000107 ! Pain relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000561 name: Fever def: "A disorder characterized by elevation of the body's temperature above the upper limit of normal OR Elevation of body temperature above normal due to inflammatory or immune responses." [NCI:CTCAE, NCIT:C3038] synonym: "Pyrexia" EXACT [NCIT:C3038] xref: UMLS:C0015967 xref: UMLS:C0424755 xref: NCI:CTCAE:10016558 xref: NCIT:C3038 property_value: ESCORT_rule "CCTO:000561 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fever'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000561 implies CCTO:001103" xsd:string ! ESCORT_rule ''Fever'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000561(time_t t0) = EVENT_STATE(CCTO:000561, t0)" xsd:string ! schema ''Fever''(time_t t0) = EVENT_STATE(''Fever'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000562 name: Flu like symptoms def: "A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough OR Complaints describing a pattern similar to influenza, and may include fever, chills, muscle or body aches, cough, sore throat, rhinitis or fatigue." [NCI:CTCAE, NCIT:C78302] synonym: "Flu-like symptoms" EXACT [NCIT:C78302] synonym: "Influenza-like illness" EXACT [NCIT:C78302] xref: UMLS:C0392171 xref: UMLS:C0521839 xref: NCI:CTCAE:10016791 xref: NCIT:C78302 property_value: ESCORT_rule "CCTO:000562 implies CCTO:000049" xsd:string ! ESCORT_rule ''Flu like symptoms'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000562 implies CCTO:001103" xsd:string ! ESCORT_rule ''Flu like symptoms'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000562(time_t t0) = EVENT_STATE(CCTO:000562, t0)" xsd:string ! schema ''Flu like symptoms''(time_t t0) = EVENT_STATE(''Flu like symptoms'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000563 name: Gait disturbance def: "A finding referring to walking difficulties OR A disorder characterized by walking difficulties." [NCIT:C78303, NCI:CTCAE] xref: UMLS:C0575081 xref: NCI:CTCAE:10017577 xref: NCIT:C78303 property_value: ESCORT_rule "CCTO:000563 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gait disturbance'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000563 implies CCTO:001103" xsd:string ! ESCORT_rule ''Gait disturbance'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000563(time_t t0) = EVENT_STATE(CCTO:000563, t0)" xsd:string ! schema ''Gait disturbance''(time_t t0) = EVENT_STATE(''Gait disturbance'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000564 name: Hypothermia def: "Abnormally low body temperature OR A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below OR Abnormally low body temperature." [NCIT:C50523, NCI:CTCAE, NCIT:C78351] synonym: "Body temperature, decreased" EXACT [NCIT:C50523] synonym: "Decreased body temperature" EXACT [NCIT:C50523] synonym: "Decreased core body temperature" EXACT [NCIT:C50523] synonym: "Hypothermia adverse event" EXACT [NCIT:C55332] synonym: "Temperature, decreased body" EXACT [NCIT:C50523] xref: UMLS:C0020672 xref: UMLS:C1963170 xref: NCI:CTCAE:10021113 xref: NCIT:C50523 xref: NCIT:C55332 xref: NCIT:C78351 property_value: ESCORT_rule "CCTO:000564 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypothermia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000564 implies CCTO:001103" xsd:string ! ESCORT_rule ''Hypothermia'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000564(time_t t0) = EVENT_STATE(CCTO:000564, t0)" xsd:string ! schema ''Hypothermia''(time_t t0) = EVENT_STATE(''Hypothermia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000565 name: Infusion related reaction def: "A reaction to the infusion of pharmacological or biological substances. Symptoms may appear within minutes to hours following the infusion and may include pruritus, flushing, swelling, dyspnea, bronchospasm, and hypotension OR A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances." [NCIT:C78361, NCI:CTCAE] synonym: "Infusion-related reaction" EXACT [NCIT:C78361] xref: UMLS:C0948715 xref: NCI:CTCAE:10051792 xref: NCIT:C78361 property_value: ESCORT_rule "CCTO:000565 implies CCTO:000049" xsd:string ! ESCORT_rule ''Infusion related reaction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000565 implies CCTO:001103" xsd:string ! ESCORT_rule ''Infusion related reaction'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000565(time_t t0) = EVENT_STATE(CCTO:000565, t0)" xsd:string ! schema ''Infusion related reaction''(time_t t0) = EVENT_STATE(''Infusion related reaction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000566 name: Infusion site extravasation def: "A disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site OR Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and pain at the infusion site." [NCI:CTCAE, NCIT:C78362] xref: UMLS:C1608954 xref: NCI:CTCAE:10064774 xref: NCIT:C78362 property_value: ESCORT_rule "CCTO:000566 implies CCTO:000049" xsd:string ! ESCORT_rule ''Infusion site extravasation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000566 implies CCTO:001103" xsd:string ! ESCORT_rule ''Infusion site extravasation'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000566(time_t t0) = EVENT_STATE(CCTO:000566, t0)" xsd:string ! schema ''Infusion site extravasation''(time_t t0) = EVENT_STATE(''Infusion site extravasation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000567 name: Irritability def: "Feelings of annoyance, impatience, and anger OR A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition OR Excited response to stimuli." [NCIT:C77966, NCI:CTCAE, NCIT:C50623] synonym: "Irritation" EXACT [NCIT:C77966] xref: UMLS:C0022107 xref: UMLS:C2700617 xref: UMLS:C1706307 xref: UMLS:C0441723 xref: NCI:CTCAE:10022998 xref: NCIT:C50623 xref: NCIT:C77966 property_value: ESCORT_rule "CCTO:000567 implies CCTO:000049" xsd:string ! ESCORT_rule ''Irritability'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000567 implies CCTO:001103" xsd:string ! ESCORT_rule ''Irritability'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000567(time_t t0) = EVENT_STATE(CCTO:000567, t0)" xsd:string ! schema ''Irritability''(time_t t0) = EVENT_STATE(''Irritability'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000568 name: Localized edema def: "Swelling due to an excessive accumulation of fluid at a specific anatomic site OR A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site." [NCIT:C78437, NCI:CTCAE] xref: UMLS:C0013609 xref: NCI:CTCAE:10062466 xref: NCIT:C78437 property_value: ESCORT_rule "CCTO:000568 implies CCTO:000226" xsd:string ! ESCORT_rule ''Localized edema'' implies ''Edema'' property_value: ESCORT_rule "CCTO:000568 implies CCTO:001103" xsd:string ! ESCORT_rule ''Localized edema'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000568(time_t t0) = EVENT_STATE(CCTO:000568, t0)" xsd:string ! schema ''Localized edema''(time_t t0) = EVENT_STATE(''Localized edema'', t0) is_a: CCTO:000226 ! Edema is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000569 name: Malaise def: "A feeling of general discomfort or uneasiness, an out-of-sorts feeling OR A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling." [NCIT:C3832, NCI:CTCAE] xref: UMLS:C0231218 xref: NCI:CTCAE:10025482 xref: NCIT:C3832 property_value: ESCORT_rule "CCTO:000569 implies CCTO:000049" xsd:string ! ESCORT_rule ''Malaise'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000569 implies CCTO:001103" xsd:string ! ESCORT_rule ''Malaise'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000569(time_t t0) = EVENT_STATE(CCTO:000569, t0)" xsd:string ! schema ''Malaise''(time_t t0) = EVENT_STATE(''Malaise'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000570 name: Multi-organ failure def: "A disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms OR Complete impairment of two or more organs or organ systems." [NCI:CTCAE, NCIT:C75568] synonym: "Death Adverse Event Due to Multi-Organ Failure Not Associated with More Specific CTCAE Term" EXACT [NCIT:C55283] synonym: "Multiple organ failure" EXACT [NCIT:C75568] synonym: "Multiple system failure" EXACT [NCIT:C75568] xref: UMLS:C0026766 xref: UMLS:C1963169 xref: NCI:CTCAE:10028154 xref: NCIT:C55283 xref: NCIT:C75568 property_value: ESCORT_rule "CCTO:000570 implies CCTO:000049" xsd:string ! ESCORT_rule ''Multi-organ failure'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000570 implies CCTO:001103" xsd:string ! ESCORT_rule ''Multi-organ failure'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000570(time_t t0) = EVENT_STATE(CCTO:000570, t0)" xsd:string ! schema ''Multi-organ failure''(time_t t0) = EVENT_STATE(''Multi-organ failure'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000571 name: Neck edema def: "A disorder characterized by swelling due to an accumulation of excessive fluid in the neck OR Swelling due to an accumulation of excessive fluid in the neck." [NCI:CTCAE, NCIT:C78501] xref: UMLS:C0240464 xref: NCI:CTCAE:10054482 xref: NCIT:C78501 property_value: ESCORT_rule "CCTO:000571 implies CCTO:000226" xsd:string ! ESCORT_rule ''Neck edema'' implies ''Edema'' property_value: ESCORT_rule "CCTO:000571 implies CCTO:001103" xsd:string ! ESCORT_rule ''Neck edema'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000571(time_t t0) = EVENT_STATE(CCTO:000571, t0)" xsd:string ! schema ''Neck edema''(time_t t0) = EVENT_STATE(''Neck edema'', t0) is_a: CCTO:000226 ! Edema is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000572 name: Non-cardiac chest pain def: "A disorder characterized by discomfort in the chest unrelated to a heart disorder OR Pain in the chest unrelated to a heart disorder." [NCI:CTCAE, NCIT:C78504] xref: UMLS:C0476281 xref: NCI:CTCAE:10062501 xref: NCIT:C78504 property_value: ESCORT_rule "CCTO:000572 implies CCTO:000107" xsd:string ! ESCORT_rule ''Non-cardiac chest pain'' implies ''Pain'' property_value: schema "CCTO:000572(time_t t0) = EVENT_STATE(CCTO:000572, t0)" xsd:string ! schema ''Non-cardiac chest pain''(time_t t0) = EVENT_STATE(''Non-cardiac chest pain'', t0) is_a: CCTO:000107 ! Pain relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000573 name: Sudden death NOS def: "An unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5." [NCI:CTCAE] xref: NCI:CTCAE:10042435 property_value: ESCORT_rule "CCTO:000573 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sudden death NOS'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000573 implies CCTO:001103" xsd:string ! ESCORT_rule ''Sudden death NOS'' implies ''General disorders and administration site conditions'' property_value: schema "CCTO:000573(time_t t0) = EVENT_STATE(CCTO:000573, t0)" xsd:string ! schema ''Sudden death NOS''(time_t t0) = EVENT_STATE(''Sudden death NOS'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001103 ! General disorders and administration site conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000574 name: Bile duct stenosis def: "A disorder characterized by a narrowing of the lumen of the bile duct OR Narrowing or stricture of the bile duct." [NCI:CTCAE, NCIT:C78182] xref: UMLS:C0267925 xref: NCI:CTCAE:10051341 xref: NCIT:C78182 property_value: ESCORT_rule "CCTO:000574 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bile duct stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000574 implies CCTO:001117" xsd:string ! ESCORT_rule ''Bile duct stenosis'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000574(time_t t0) = EVENT_STATE(CCTO:000574, t0)" xsd:string ! schema ''Bile duct stenosis''(time_t t0) = EVENT_STATE(''Bile duct stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000575 name: Biliary fistula def: "An abnormal communication between the bile ducts and another organ or cavity OR A disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site." [NCIT:C79540, NCI:CTCAE] xref: UMLS:C0005417 xref: NCI:CTCAE:10004665 xref: NCIT:C79540 property_value: ESCORT_rule "CCTO:000575 implies CCTO:000049" xsd:string ! ESCORT_rule ''Biliary fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000575 implies CCTO:001117" xsd:string ! ESCORT_rule ''Biliary fistula'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000575(time_t t0) = EVENT_STATE(CCTO:000575, t0)" xsd:string ! schema ''Biliary fistula''(time_t t0) = EVENT_STATE(''Biliary fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000576 name: Cholecystitis def: "A disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones OR An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones." [NCI:CTCAE, NCIT:C34465] synonym: "Cholecystitis adverse event" EXACT [NCIT:C56575] xref: UMLS:C0008325 xref: UMLS:C1963083 xref: NCI:CTCAE:10008612 xref: NCIT:C34465 xref: NCIT:C56575 property_value: ESCORT_rule "CCTO:000576 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cholecystitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000576 implies CCTO:001117" xsd:string ! ESCORT_rule ''Cholecystitis'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000576(time_t t0) = EVENT_STATE(CCTO:000576, t0)" xsd:string ! schema ''Cholecystitis''(time_t t0) = EVENT_STATE(''Cholecystitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000577 name: Gallbladder fistula def: "A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site OR An abnormal communication between the gallbladder and another organ or cavity." [NCI:CTCAE, NCIT:C78305] synonym: "Gallbladder fistula adverse event" EXACT [NCIT:C57808] xref: UMLS:C0156216 xref: UMLS:C1963110 xref: NCI:CTCAE:10017631 xref: NCIT:C57808 xref: NCIT:C78305 property_value: ESCORT_rule "CCTO:000577 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gallbladder fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000577 implies CCTO:001117" xsd:string ! ESCORT_rule ''Gallbladder fistula'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000577(time_t t0) = EVENT_STATE(CCTO:000577, t0)" xsd:string ! schema ''Gallbladder fistula''(time_t t0) = EVENT_STATE(''Gallbladder fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000578 name: Gallbladder necrosis def: "A disorder characterized by a necrotic process occurring in the gallbladder OR A necrotic process occurring in the gallbladder." [NCI:CTCAE, NCIT:C78307] synonym: "Gallbladder necrosis adverse event" EXACT [NCIT:C57809] synonym: "Gallbladder necrotic lesion" EXACT [NCIT:C78307] xref: UMLS:C1963114 xref: UMLS:C1167767 xref: NCI:CTCAE:10059446 xref: NCIT:C57809 xref: NCIT:C78307 property_value: ESCORT_rule "CCTO:000578 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gallbladder necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000578 implies CCTO:001117" xsd:string ! ESCORT_rule ''Gallbladder necrosis'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000578(time_t t0) = EVENT_STATE(CCTO:000578, t0)" xsd:string ! schema ''Gallbladder necrosis''(time_t t0) = EVENT_STATE(''Gallbladder necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000579 name: Gallbladder obstruction def: "Blockage of the normal flow of the contents of the gallbladder OR A disorder characterized by blockage of the normal flow of the contents of the gallbladder." [NCIT:C78308, NCI:CTCAE] synonym: "Gallbladder obstruction adverse event" EXACT [NCIT:C57810] xref: UMLS:C1964021 xref: UMLS:C0156214 xref: NCI:CTCAE:10017636 xref: NCIT:C57810 xref: NCIT:C78308 property_value: ESCORT_rule "CCTO:000579 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gallbladder obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000579 implies CCTO:001117" xsd:string ! ESCORT_rule ''Gallbladder obstruction'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000579(time_t t0) = EVENT_STATE(CCTO:000579, t0)" xsd:string ! schema ''Gallbladder obstruction''(time_t t0) = EVENT_STATE(''Gallbladder obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000580 name: Gallbladder pain def: "A disorder characterized by a sensation of marked discomfort in the gallbladder region OR Painful sensation in the gallbladder region." [NCI:CTCAE, NCIT:C78304] synonym: "Gallbladder pain adverse event" EXACT [NCIT:C56080] xref: UMLS:C0151824 xref: UMLS:C1963072 xref: NCI:CTCAE:10017638 xref: NCIT:C56080 xref: NCIT:C78304 property_value: ESCORT_rule "CCTO:000580 implies CCTO:000107" xsd:string ! ESCORT_rule ''Gallbladder pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000580 implies CCTO:001117" xsd:string ! ESCORT_rule ''Gallbladder pain'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000580(time_t t0) = EVENT_STATE(CCTO:000580, t0)" xsd:string ! schema ''Gallbladder pain''(time_t t0) = EVENT_STATE(''Gallbladder pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000581 name: Gallbladder perforation def: "A disorder characterized by a rupture in the gallbladder wall OR A rupture in the gallbladder wall caused by traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78309] synonym: "Gallbladder perforation adverse event" EXACT [NCIT:C57811] xref: UMLS:C1963204 xref: UMLS:C0156215 xref: NCI:CTCAE:10017639 xref: NCIT:C57811 xref: NCIT:C78309 property_value: ESCORT_rule "CCTO:000581 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gallbladder perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000581 implies CCTO:001117" xsd:string ! ESCORT_rule ''Gallbladder perforation'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000581(time_t t0) = EVENT_STATE(CCTO:000581, t0)" xsd:string ! schema ''Gallbladder perforation''(time_t t0) = EVENT_STATE(''Gallbladder perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000582 name: Hepatic failure def: "A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase OR A disorder characterized by the inability of the liver to metabolize chemicals in the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase." [NCI:CTCAE, NCIT:C26922] synonym: "Liver failure" EXACT [NCIT:C26922] xref: UMLS:C0085605 xref: NCI:CTCAE:10019663 xref: NCIT:C26922 property_value: ESCORT_rule "CCTO:000582 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hepatic failure'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000582 implies CCTO:001117" xsd:string ! ESCORT_rule ''Hepatic failure'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000582(time_t t0) = EVENT_STATE(CCTO:000582, t0)" xsd:string ! schema ''Hepatic failure''(time_t t0) = EVENT_STATE(''Hepatic failure'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000583 name: Hepatic hemorrhage def: "Bleeding originating from the liver OR A disorder characterized by bleeding from the liver." [NCIT:C78338, NCI:CTCAE] xref: UMLS:C0235912 xref: NCI:CTCAE:10019678 xref: NCIT:C78338 property_value: ESCORT_rule "CCTO:000583 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hepatic hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000583 implies CCTO:001117" xsd:string ! ESCORT_rule ''Hepatic hemorrhage'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000583(time_t t0) = EVENT_STATE(CCTO:000583, t0)" xsd:string ! schema ''Hepatic hemorrhage''(time_t t0) = EVENT_STATE(''Hepatic hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000584 name: Hepatic necrosis def: "A disorder characterized by a necrotic process occurring in the hepatic parenchyma OR A necrotic process affecting the hepatic parenchyma." [NCI:CTCAE, NCIT:C78340] synonym: "Hepatic necrosis adverse event" EXACT [NCIT:C57820] synonym: "Hepatic necrotic lesion" EXACT [NCIT:C78340] xref: UMLS:C0151798 xref: UMLS:C1963135 xref: NCI:CTCAE:10019692 xref: NCIT:C57820 xref: NCIT:C78340 property_value: ESCORT_rule "CCTO:000584 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hepatic necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000584 implies CCTO:001117" xsd:string ! ESCORT_rule ''Hepatic necrosis'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000584(time_t t0) = EVENT_STATE(CCTO:000584, t0)" xsd:string ! schema ''Hepatic necrosis''(time_t t0) = EVENT_STATE(''Hepatic necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000585 name: Hepatic pain def: "A disorder characterized by a sensation of marked discomfort in the liver region OR A painful sensation in the liver." [NCI:CTCAE, NCIT:C78341] xref: UMLS:C0522067 xref: NCI:CTCAE:10019705 xref: NCIT:C78341 property_value: ESCORT_rule "CCTO:000585 implies CCTO:000107" xsd:string ! ESCORT_rule ''Hepatic pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000585 implies CCTO:001117" xsd:string ! ESCORT_rule ''Hepatic pain'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000585(time_t t0) = EVENT_STATE(CCTO:000585, t0)" xsd:string ! schema ''Hepatic pain''(time_t t0) = EVENT_STATE(''Hepatic pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000586 name: Perforation bile duct def: "A rupture in the wall of the extrahepatic or intrahepatic bile duct due to traumatic or pathologic processes OR A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct." [NCIT:C78528, NCI:CTCAE] synonym: "Bile duct perforation" EXACT [NCIT:C78528] xref: UMLS:C0156218 xref: NCI:CTCAE:10034405 xref: NCIT:C78528 property_value: ESCORT_rule "CCTO:000586 implies CCTO:000049" xsd:string ! ESCORT_rule ''Perforation bile duct'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000586 implies CCTO:001117" xsd:string ! ESCORT_rule ''Perforation bile duct'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000586(time_t t0) = EVENT_STATE(CCTO:000586, t0)" xsd:string ! schema ''Perforation bile duct''(time_t t0) = EVENT_STATE(''Perforation bile duct'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000587 name: Portal hypertension def: "Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly OR A disorder characterized by an increase in blood pressure in the portal venous system." [NCIT:C3119, NCI:CTCAE] xref: UMLS:C0020541 xref: NCI:CTCAE:10036200 xref: NCIT:C3119 property_value: ESCORT_rule "CCTO:000587 implies CCTO:000049" xsd:string ! ESCORT_rule ''Portal hypertension'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000587 implies CCTO:001117" xsd:string ! ESCORT_rule ''Portal hypertension'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000587(time_t t0) = EVENT_STATE(CCTO:000587, t0)" xsd:string ! schema ''Portal hypertension''(time_t t0) = EVENT_STATE(''Portal hypertension'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000588 name: Portal vein thrombosis def: "The formation of a blood clot (thrombus) in the portal vein OR A disorder characterized by the formation of a thrombus (blood clot) in the portal vein." [NCIT:C78565, NCI:CTCAE] xref: UMLS:C0155773 xref: NCI:CTCAE:10036206 xref: NCIT:C78565 property_value: ESCORT_rule "CCTO:000588 implies CCTO:000049" xsd:string ! ESCORT_rule ''Portal vein thrombosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000588 implies CCTO:001117" xsd:string ! ESCORT_rule ''Portal vein thrombosis'' implies ''Hepatobiliary disorders'' property_value: schema "CCTO:000588(time_t t0) = EVENT_STATE(CCTO:000588, t0)" xsd:string ! schema ''Portal vein thrombosis''(time_t t0) = EVENT_STATE(''Portal vein thrombosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001117 ! Hepatobiliary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000589 name: Allergic reaction def: "An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures OR A disorder characterized by an adverse local or general response from exposure to an allergen OR An immune response that occurs following exposure to an innocuous antigen, but that does not require the presence of preformed antibodies to the antigen." [NCIT:C114476, NCI:CTCAE, NCIT:C3114] synonym: "Allergy" EXACT [NCIT:C114476] synonym: "Hypersensitive" EXACT [NCIT:C3114] synonym: "Hypersensitivity reaction" EXACT [NCIT:C3114] synonym: "Hypersensitivity" EXACT [NCIT:C3114] synonym: "Sensitive" EXACT [NCIT:C3114] synonym: "Sensitivity" EXACT [NCIT:C3114] synonym: "allergic response" EXACT [NCIT:C114476] xref: UMLS:C0020517 xref: UMLS:C1527304 xref: UMLS:C1550474 xref: UMLS:C0036667 xref: UMLS:C1554743 xref: UMLS:C1314973 xref: UMLS:C2349185 xref: UMLS:C0002111 xref: UMLS:C0332324 xref: UMLS:C2346484 xref: NCI:CTCAE:10001718 xref: NCIT:C114476 xref: NCIT:C3114 property_value: ESCORT_rule "CCTO:000589 implies CCTO:000049" xsd:string ! ESCORT_rule ''Allergic reaction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000589 implies CCTO:001118" xsd:string ! ESCORT_rule ''Allergic reaction'' implies ''Immune system disorders'' property_value: schema "CCTO:000589(time_t t0) = EVENT_STATE(CCTO:000589, t0)" xsd:string ! schema ''Allergic reaction''(time_t t0) = EVENT_STATE(''Allergic reaction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001118 ! Immune system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000590 name: Anaphylaxis def: "Progression of anaphylaxis into systemic shock, which is characterized by significant reduction in tissue perfusion which leads to hypoxia and hypotension, and can lead to death if untreated OR An acute hypersensitive immune response that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting OR A disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death." [NCIT:C50460, NCIT:C107101, NCI:CTCAE] synonym: "Anaphylactic shock" EXACT [NCIT:C50460] synonym: "Shock, anaphylactic" EXACT [NCIT:C50460] xref: UMLS:C0002792 xref: NCI:CTCAE:10002218 xref: NCIT:C107101 xref: NCIT:C50460 property_value: ESCORT_rule "CCTO:000590 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anaphylaxis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000590 implies CCTO:001118" xsd:string ! ESCORT_rule ''Anaphylaxis'' implies ''Immune system disorders'' property_value: schema "CCTO:000590(time_t t0) = EVENT_STATE(CCTO:000590, t0)" xsd:string ! schema ''Anaphylaxis''(time_t t0) = EVENT_STATE(''Anaphylaxis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001118 ! Immune system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000591 name: Autoimmune disorder def: "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis) OR A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents." [NCIT:C2889, NCI:CTCAE] synonym: "Autoimmune disease" EXACT [NCIT:C2889] synonym: "Disease, autoimmune" EXACT [NCIT:C2889] xref: UMLS:C0004364 xref: NCI:CTCAE:10061664 xref: NCIT:C2889 property_value: ESCORT_rule "CCTO:000591 implies CCTO:000049" xsd:string ! ESCORT_rule ''Autoimmune disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000591 implies CCTO:001118" xsd:string ! ESCORT_rule ''Autoimmune disorder'' implies ''Immune system disorders'' property_value: schema "CCTO:000591(time_t t0) = EVENT_STATE(CCTO:000591, t0)" xsd:string ! schema ''Autoimmune disorder''(time_t t0) = EVENT_STATE(''Autoimmune disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001118 ! Immune system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000592 name: Cytokine release syndrome def: "A syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath. It is caused by the release of cytokines from the cells that are targeted by the antibodies. Most patients experience a mild to moderate reaction; however, the reaction may be severe and life-threatening OR A disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells." [NCIT:C78251, NCI:CTCAE] xref: UMLS:C0948245 xref: NCI:CTCAE:10052015 xref: NCIT:C78251 property_value: ESCORT_rule "CCTO:000592 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cytokine release syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000592 implies CCTO:001118" xsd:string ! ESCORT_rule ''Cytokine release syndrome'' implies ''Immune system disorders'' property_value: schema "CCTO:000592(time_t t0) = EVENT_STATE(CCTO:000592, t0)" xsd:string ! schema ''Cytokine release syndrome''(time_t t0) = EVENT_STATE(''Cytokine release syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001118 ! Immune system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000593 name: Serum sickness def: "Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction OR A disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea." [NCIT:C79718, NCI:CTCAE] synonym: "Serum sickness adverse event" EXACT [NCIT:C54740] xref: UMLS:C0036830 xref: UMLS:C1963234 xref: NCI:CTCAE:10040400 xref: NCIT:C54740 xref: NCIT:C79718 property_value: ESCORT_rule "CCTO:000593 implies CCTO:000049" xsd:string ! ESCORT_rule ''Serum sickness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000593 implies CCTO:001118" xsd:string ! ESCORT_rule ''Serum sickness'' implies ''Immune system disorders'' property_value: schema "CCTO:000593(time_t t0) = EVENT_STATE(CCTO:000593, t0)" xsd:string ! schema ''Serum sickness''(time_t t0) = EVENT_STATE(''Serum sickness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001118 ! Immune system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000594 name: Abdominal infection def: "Infection in the abdominal cavity resulting from injury, acute intestinal inflammation (e.g., acute appendicitis), intestinal perforation, or complication of abdominal surgery OR A disorder characterized by an infectious process involving the abdominal cavity." [NCIT:C35669, NCI:CTCAE] xref: UMLS:C1112209 xref: NCI:CTCAE:10056519 xref: NCIT:C35669 property_value: ESCORT_rule "CCTO:000594 implies CCTO:000049" xsd:string ! ESCORT_rule ''Abdominal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000594 implies CCTO:001119" xsd:string ! ESCORT_rule ''Abdominal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000594(time_t t0) = EVENT_STATE(CCTO:000594, t0)" xsd:string ! schema ''Abdominal infection''(time_t t0) = EVENT_STATE(''Abdominal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000595 name: Anorectal infection def: "A disorder characterized by an infectious process involving the anal area and the rectum OR An infectious process affecting the anal area and the rectum." [NCI:CTCAE, NCIT:C78174] xref: UMLS:C2700620 xref: NCI:CTCAE:10061640 xref: NCIT:C78174 property_value: ESCORT_rule "CCTO:000595 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anorectal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000595 implies CCTO:001119" xsd:string ! ESCORT_rule ''Anorectal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000595(time_t t0) = EVENT_STATE(CCTO:000595, t0)" xsd:string ! schema ''Anorectal infection''(time_t t0) = EVENT_STATE(''Anorectal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000596 name: Appendicitis def: "A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent OR Acute inflammation of the vermiform appendix." [NCI:CTCAE, NCIT:C35145] synonym: "Acute appendicitis" EXACT [NCIT:C35145] xref: UMLS:C0085693 xref: UMLS:C0003615 xref: NCI:CTCAE:10003011 xref: NCIT:C35145 property_value: ESCORT_rule "CCTO:000596 implies CCTO:000049" xsd:string ! ESCORT_rule ''Appendicitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000596 implies CCTO:001119" xsd:string ! ESCORT_rule ''Appendicitis'' implies ''Infections and infestations'' property_value: schema "CCTO:000596(time_t t0) = EVENT_STATE(CCTO:000596, t0)" xsd:string ! schema ''Appendicitis''(time_t t0) = EVENT_STATE(''Appendicitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000597 name: Appendicitis perforated def: "Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity OR A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity." [NCIT:C78178, NCI:CTCAE] synonym: "Acute perforated appendicitis" EXACT [NCIT:C78178] xref: UMLS:C0564755 xref: UMLS:C0854119 xref: NCI:CTCAE:10003012 xref: NCIT:C78178 property_value: ESCORT_rule "CCTO:000597 implies CCTO:000049" xsd:string ! ESCORT_rule ''Appendicitis perforated'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000597 implies CCTO:001119" xsd:string ! ESCORT_rule ''Appendicitis perforated'' implies ''Infections and infestations'' property_value: schema "CCTO:000597(time_t t0) = EVENT_STATE(CCTO:000597, t0)" xsd:string ! schema ''Appendicitis perforated''(time_t t0) = EVENT_STATE(''Appendicitis perforated'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000598 name: Arteritis infective def: "A disorder characterized by an infectious process involving an artery OR A bacterial or viral infectious process affecting an artery." [NCI:CTCAE, NCIT:C83506] synonym: "Infectious arteritis" EXACT [NCIT:C83506] xref: UMLS:C1697748 xref: NCI:CTCAE:10065744 xref: NCIT:C83506 property_value: ESCORT_rule "CCTO:000598 implies CCTO:000049" xsd:string ! ESCORT_rule ''Arteritis infective'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000598 implies CCTO:001119" xsd:string ! ESCORT_rule ''Arteritis infective'' implies ''Infections and infestations'' property_value: schema "CCTO:000598(time_t t0) = EVENT_STATE(CCTO:000598, t0)" xsd:string ! schema ''Arteritis infective''(time_t t0) = EVENT_STATE(''Arteritis infective'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000599 name: Biliary tract infection def: "A disorder characterized by an infectious process involving the biliary tract OR An acute or chronic inflammatory process affecting the biliary tract." [NCI:CTCAE, NCIT:C26718] synonym: "Cholangitis" EXACT [NCIT:C26718] xref: UMLS:C0008311 xref: UMLS:C0920156 xref: NCI:CTCAE:10061695 xref: NCIT:C26718 property_value: ESCORT_rule "CCTO:000599 implies CCTO:000049" xsd:string ! ESCORT_rule ''Biliary tract infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000599 implies CCTO:001119" xsd:string ! ESCORT_rule ''Biliary tract infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000599(time_t t0) = EVENT_STATE(CCTO:000599, t0)" xsd:string ! schema ''Biliary tract infection''(time_t t0) = EVENT_STATE(''Biliary tract infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000600 name: Bladder infection def: "An infectious process affecting the urinary bladder OR A disorder characterized by an infectious process involving the bladder OR Inflammation of the urinary bladder." [NCIT:C83816, NCI:CTCAE, NCIT:C26738] synonym: "Cystitis" EXACT [NCIT:C26738] synonym: "Infectious cystitis" EXACT [NCIT:C83816] xref: UMLS:C0600041 xref: UMLS:C0010692 xref: NCI:CTCAE:10005047 xref: NCIT:C26738 xref: NCIT:C83816 property_value: ESCORT_rule "CCTO:000600 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bladder infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000600 implies CCTO:001119" xsd:string ! ESCORT_rule ''Bladder infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000600(time_t t0) = EVENT_STATE(CCTO:000600, t0)" xsd:string ! schema ''Bladder infection''(time_t t0) = EVENT_STATE(''Bladder infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000601 name: Bone infection def: "A disorder characterized by an infectious process involving the bones OR An acute or chronic infectious process affecting the bones." [NCI:CTCAE, NCIT:C26839] xref: UMLS:C2242472 xref: NCI:CTCAE:10061017 xref: NCIT:C26839 property_value: ESCORT_rule "CCTO:000601 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bone infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000601 implies CCTO:001119" xsd:string ! ESCORT_rule ''Bone infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000601(time_t t0) = EVENT_STATE(CCTO:000601, t0)" xsd:string ! schema ''Bone infection''(time_t t0) = EVENT_STATE(''Bone infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000602 name: Breast infection def: "A disorder characterized by an infectious process involving the breast OR Inflammation of breast tissue during lactation or postpartum due to an obstructed duct or infection." [NCI:CTCAE, NCIT:C53662] synonym: "Mastitis" EXACT [NCIT:C53662] xref: UMLS:C0392317 xref: UMLS:C3251795 xref: UMLS:C0024894 xref: NCI:CTCAE:10006259 xref: NCIT:C53662 property_value: ESCORT_rule "CCTO:000602 implies CCTO:000049" xsd:string ! ESCORT_rule ''Breast infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000602 implies CCTO:001119" xsd:string ! ESCORT_rule ''Breast infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000602(time_t t0) = EVENT_STATE(CCTO:000602, t0)" xsd:string ! schema ''Breast infection''(time_t t0) = EVENT_STATE(''Breast infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000603 name: Bronchial infection def: "A disorder characterized by an infectious process involving the bronchi OR An acute or chronic inflammatory process affecting the bronchi." [NCI:CTCAE, NCIT:C2911] synonym: "Bronchitis" EXACT [NCIT:C2911] xref: UMLS:C0006277 xref: UMLS:C0340238 xref: NCI:CTCAE:10055078 xref: NCIT:C2911 property_value: ESCORT_rule "CCTO:000603 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchial infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000603 implies CCTO:001119" xsd:string ! ESCORT_rule ''Bronchial infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000603(time_t t0) = EVENT_STATE(CCTO:000603, t0)" xsd:string ! schema ''Bronchial infection''(time_t t0) = EVENT_STATE(''Bronchial infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000604 name: Catheter related infection def: "A disorder characterized by an infectious process that arises secondary to catheter use OR An infection that arises secondary to catheter use." [NCI:CTCAE, NCIT:C78232] synonym: "Catheter-related infection" EXACT [NCIT:C78232] xref: UMLS:C0860239 xref: NCI:CTCAE:10007810 xref: NCIT:C78232 property_value: ESCORT_rule "CCTO:000604 implies CCTO:000049" xsd:string ! ESCORT_rule ''Catheter related infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000604 implies CCTO:001119" xsd:string ! ESCORT_rule ''Catheter related infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000604(time_t t0) = EVENT_STATE(CCTO:000604, t0)" xsd:string ! schema ''Catheter related infection''(time_t t0) = EVENT_STATE(''Catheter related infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000605 name: Cecal infection def: "An infectious process affecting the cecum OR A disorder characterized by an infectious process involving the cecum." [NCIT:C78235, NCI:CTCAE] xref: UMLS:C1699694 xref: NCI:CTCAE:10065761 xref: NCIT:C78235 property_value: ESCORT_rule "CCTO:000605 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cecal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000605 implies CCTO:001119" xsd:string ! ESCORT_rule ''Cecal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000605(time_t t0) = EVENT_STATE(CCTO:000605, t0)" xsd:string ! schema ''Cecal infection''(time_t t0) = EVENT_STATE(''Cecal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000606 name: Cervicitis infection def: "A disorder characterized by an infectious process involving the uterine cervix OR An infectious process affecting the uterine cervix. Causative agents include Neisseria gonorrhoeae, Chlamydia trachomatis, human papillomavirus, and herpes simplex virus. Physical examination reveals an erythematous, raised lesion in the cervix and mucopurulent discharge." [NCI:CTCAE, NCIT:C78360] synonym: "Infectious cervicitis" EXACT [NCIT:C78360] xref: UMLS:C0856203 xref: NCI:CTCAE:10008330 xref: NCIT:C78360 property_value: ESCORT_rule "CCTO:000606 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cervicitis infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000606 implies CCTO:001119" xsd:string ! ESCORT_rule ''Cervicitis infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000606(time_t t0) = EVENT_STATE(CCTO:000606, t0)" xsd:string ! schema ''Cervicitis infection''(time_t t0) = EVENT_STATE(''Cervicitis infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000607 name: Conjunctivitis infective def: "An infectious process affecting the conjunctiva OR Acute inflammation of the conjunctiva characterized by pink or red color in the eyes OR A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes." [NCIT:C83508, NCIT:C35704, NCI:CTCAE] synonym: "Acute contagious conjunctivitis" EXACT [NCIT:C35704] synonym: "Infectious conjunctivitis" EXACT [NCIT:C83508] synonym: "Pinkeye" EXACT [NCIT:C35704] xref: UMLS:C1313983 xref: UMLS:C0497209 xref: NCI:CTCAE:10010742 xref: NCIT:C35704 xref: NCIT:C83508 property_value: ESCORT_rule "CCTO:000607 implies CCTO:000049" xsd:string ! ESCORT_rule ''Conjunctivitis infective'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000607 implies CCTO:001119" xsd:string ! ESCORT_rule ''Conjunctivitis infective'' implies ''Infections and infestations'' property_value: schema "CCTO:000607(time_t t0) = EVENT_STATE(CCTO:000607, t0)" xsd:string ! schema ''Conjunctivitis infective''(time_t t0) = EVENT_STATE(''Conjunctivitis infective'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000608 name: Corneal infection def: "A viral or bacterial infectious process affecting the cornea. Symptoms include pain and redness in the eye, photophobia and eye watering OR A disorder characterized by an infectious process involving the cornea." [NCIT:C83813, NCI:CTCAE] xref: UMLS:C0729777 xref: NCI:CTCAE:10061788 xref: NCIT:C83813 property_value: ESCORT_rule "CCTO:000608 implies CCTO:000049" xsd:string ! ESCORT_rule ''Corneal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000608 implies CCTO:001119" xsd:string ! ESCORT_rule ''Corneal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000608(time_t t0) = EVENT_STATE(CCTO:000608, t0)" xsd:string ! schema ''Corneal infection''(time_t t0) = EVENT_STATE(''Corneal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000609 name: Cranial nerve infection def: "An infectious process affecting a cranial nerve OR A disorder characterized by an infectious process involving a cranial nerve." [NCIT:C78248, NCI:CTCAE] xref: UMLS:C1697749 xref: NCI:CTCAE:10065765 xref: NCIT:C78248 property_value: ESCORT_rule "CCTO:000609 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cranial nerve infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000609 implies CCTO:001119" xsd:string ! ESCORT_rule ''Cranial nerve infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000609(time_t t0) = EVENT_STATE(CCTO:000609, t0)" xsd:string ! schema ''Cranial nerve infection''(time_t t0) = EVENT_STATE(''Cranial nerve infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000610 name: Device related infection def: "An infectious disorder caused by the use of a medical device OR A disorder characterized by an infectious process involving the use of a medical device OR A bacterial infection related to a device used to replace a missing body part. The infection may occur during the operation from direct contamination or post-operatively through hematogenous spread." [NCIT:C78255, NCI:CTCAE, NCIT:C79705] synonym: "Device-related infection" EXACT [NCIT:C78255] synonym: "Prosthesis-related infection" EXACT [NCIT:C79705] xref: UMLS:C1619702 xref: UMLS:C0085073 xref: NCI:CTCAE:10064687 xref: NCIT:C78255 xref: NCIT:C79705 property_value: ESCORT_rule "CCTO:000610 implies CCTO:000049" xsd:string ! ESCORT_rule ''Device related infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000610 implies CCTO:001119" xsd:string ! ESCORT_rule ''Device related infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000610(time_t t0) = EVENT_STATE(CCTO:000610, t0)" xsd:string ! schema ''Device related infection''(time_t t0) = EVENT_STATE(''Device related infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000611 name: Duodenal infection def: "An infectious process affecting the duodenum OR A disorder characterized by an infectious process involving the duodenum." [NCIT:C78258, NCI:CTCAE] xref: UMLS:C1698629 xref: NCI:CTCAE:10065752 xref: NCIT:C78258 property_value: ESCORT_rule "CCTO:000611 implies CCTO:000049" xsd:string ! ESCORT_rule ''Duodenal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000611 implies CCTO:001119" xsd:string ! ESCORT_rule ''Duodenal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000611(time_t t0) = EVENT_STATE(CCTO:000611, t0)" xsd:string ! schema ''Duodenal infection''(time_t t0) = EVENT_STATE(''Duodenal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000612 name: Encephalitis infection def: "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi OR A disorder characterized by an infectious process involving the brain tissue." [NCIT:C79550, NCI:CTCAE] synonym: "Infectious encephalitis" EXACT [NCIT:C79550] xref: UMLS:C0596773 xref: NCI:CTCAE:10014594 xref: NCIT:C79550 property_value: ESCORT_rule "CCTO:000612 implies CCTO:000049" xsd:string ! ESCORT_rule ''Encephalitis infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000612 implies CCTO:001119" xsd:string ! ESCORT_rule ''Encephalitis infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000612(time_t t0) = EVENT_STATE(CCTO:000612, t0)" xsd:string ! schema ''Encephalitis infection''(time_t t0) = EVENT_STATE(''Encephalitis infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000613 name: Encephalomyelitis infection def: "A disorder characterized by an infectious process involving the brain and spinal cord tissues OR An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses." [NCI:CTCAE, NCIT:C79551] synonym: "Infectious encephalomyelitis" EXACT [NCIT:C79551] xref: UMLS:C0856705 xref: NCI:CTCAE:10014621 xref: NCIT:C79551 property_value: ESCORT_rule "CCTO:000613 implies CCTO:000049" xsd:string ! ESCORT_rule ''Encephalomyelitis infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000613 implies CCTO:001119" xsd:string ! ESCORT_rule ''Encephalomyelitis infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000613(time_t t0) = EVENT_STATE(CCTO:000613, t0)" xsd:string ! schema ''Encephalomyelitis infection''(time_t t0) = EVENT_STATE(''Encephalomyelitis infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000614 name: Endocarditis infective def: "A disorder characterized by an infectious process involving the endocardial layer of the heart OR An infectious process involving the endocardial layer of the heart." [NCI:CTCAE, NCIT:C78265] synonym: "Infective endocarditis" EXACT [NCIT:C78265] xref: UMLS:C1541923 xref: UMLS:C0014121 xref: NCI:CTCAE:10014678 xref: NCIT:C78265 property_value: ESCORT_rule "CCTO:000614 implies CCTO:000049" xsd:string ! ESCORT_rule ''Endocarditis infective'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000614 implies CCTO:001119" xsd:string ! ESCORT_rule ''Endocarditis infective'' implies ''Infections and infestations'' property_value: schema "CCTO:000614(time_t t0) = EVENT_STATE(CCTO:000614, t0)" xsd:string ! schema ''Endocarditis infective''(time_t t0) = EVENT_STATE(''Endocarditis infective'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000615 name: Endophthalmitis def: "An infectious process affecting the internal structures of the eye OR A disorder characterized by an infectious process involving the internal structures of the eye." [NCIT:C34586, NCI:CTCAE] xref: UMLS:C0014236 xref: NCI:CTCAE:10014801 xref: NCIT:C34586 property_value: ESCORT_rule "CCTO:000615 implies CCTO:000049" xsd:string ! ESCORT_rule ''Endophthalmitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000615 implies CCTO:001119" xsd:string ! ESCORT_rule ''Endophthalmitis'' implies ''Infections and infestations'' property_value: schema "CCTO:000615(time_t t0) = EVENT_STATE(CCTO:000615, t0)" xsd:string ! schema ''Endophthalmitis''(time_t t0) = EVENT_STATE(''Endophthalmitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000616 name: Enterocolitis infectious def: "A disorder characterized by an infectious process involving the small and large intestines OR An infectious process affecting the small and large intestines. Symptoms include diarrhea, cramping abdominal pain, and fever." [NCI:CTCAE, NCIT:C80513] synonym: "Infectious enterocolitis" EXACT [NCIT:C80513] xref: UMLS:C1142115 xref: NCI:CTCAE:10058838 xref: NCIT:C80513 property_value: ESCORT_rule "CCTO:000616 implies CCTO:000049" xsd:string ! ESCORT_rule ''Enterocolitis infectious'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000616 implies CCTO:001119" xsd:string ! ESCORT_rule ''Enterocolitis infectious'' implies ''Infections and infestations'' property_value: schema "CCTO:000616(time_t t0) = EVENT_STATE(CCTO:000616, t0)" xsd:string ! schema ''Enterocolitis infectious''(time_t t0) = EVENT_STATE(''Enterocolitis infectious'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000617 name: Esophageal infection def: "A disorder characterized by an infectious process involving the esophagus OR An infectious process affecting the esophagus." [NCI:CTCAE, NCIT:C78277] xref: UMLS:C0851979 xref: NCI:CTCAE:10058804 xref: NCIT:C78277 property_value: ESCORT_rule "CCTO:000617 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000617 implies CCTO:001119" xsd:string ! ESCORT_rule ''Esophageal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000617(time_t t0) = EVENT_STATE(CCTO:000617, t0)" xsd:string ! schema ''Esophageal infection''(time_t t0) = EVENT_STATE(''Esophageal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000618 name: Eye infection def: "An infectious process affecting any part of the eye. Causes include viruses and bacteria. Symptoms include itching and discomfort in the eye, watery eyes, eye pain and discharge, and blurring vision. Representative examples include pink eye, blepharitis, and trachoma OR A disorder characterized by an infectious process involving the eye." [NCIT:C45372, NCI:CTCAE] xref: UMLS:C0015403 xref: NCI:CTCAE:10015929 xref: NCIT:C45372 property_value: ESCORT_rule "CCTO:000618 implies CCTO:000049" xsd:string ! ESCORT_rule ''Eye infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000618 implies CCTO:001119" xsd:string ! ESCORT_rule ''Eye infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000618(time_t t0) = EVENT_STATE(CCTO:000618, t0)" xsd:string ! schema ''Eye infection''(time_t t0) = EVENT_STATE(''Eye infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000619 name: Gallbladder infection def: "An acute or chronic infectious process affecting the gallbladder OR A disorder characterized by an infectious process involving the gallbladder." [NCIT:C78306, NCI:CTCAE] xref: UMLS:C0744254 xref: NCI:CTCAE:10062632 xref: NCIT:C78306 property_value: ESCORT_rule "CCTO:000619 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gallbladder infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000619 implies CCTO:001119" xsd:string ! ESCORT_rule ''Gallbladder infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000619(time_t t0) = EVENT_STATE(CCTO:000619, t0)" xsd:string ! schema ''Gallbladder infection''(time_t t0) = EVENT_STATE(''Gallbladder infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000620 name: Gum infection def: "A disorder characterized by an infectious process involving the gums OR An acute or chronic infectious process affecting the gums." [NCI:CTCAE, NCIT:C78329] xref: UMLS:C0744403 xref: NCI:CTCAE:10018784 xref: NCIT:C78329 property_value: ESCORT_rule "CCTO:000620 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gum infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000620 implies CCTO:001119" xsd:string ! ESCORT_rule ''Gum infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000620(time_t t0) = EVENT_STATE(CCTO:000620, t0)" xsd:string ! schema ''Gum infection''(time_t t0) = EVENT_STATE(''Gum infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000621 name: Hepatic infection def: "An acute or chronic infectious process affecting the liver OR A disorder characterized by an infectious process involving the liver." [NCIT:C78339, NCI:CTCAE] xref: UMLS:C1112211 xref: NCI:CTCAE:10056522 xref: NCIT:C78339 property_value: ESCORT_rule "CCTO:000621 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hepatic infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000621 implies CCTO:001119" xsd:string ! ESCORT_rule ''Hepatic infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000621(time_t t0) = EVENT_STATE(CCTO:000621, t0)" xsd:string ! schema ''Hepatic infection''(time_t t0) = EVENT_STATE(''Hepatic infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000622 name: Hepatitis viral def: "An acute or chronic inflammation of the liver parenchyma caused by viruses. Representative examples include hepatitis A, B, and C, cytomegalovirus hepatitis, and herpes simplex hepatitis OR A disorder characterized by a viral pathologic process involving the liver parenchyma." [NCIT:C35124, NCI:CTCAE] synonym: "Viral hepatitis" EXACT [NCIT:C35124] xref: UMLS:C0042721 xref: NCI:CTCAE:10019799 xref: NCIT:C35124 property_value: ESCORT_rule "CCTO:000622 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hepatitis viral'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000622 implies CCTO:001119" xsd:string ! ESCORT_rule ''Hepatitis viral'' implies ''Infections and infestations'' property_value: schema "CCTO:000622(time_t t0) = EVENT_STATE(CCTO:000622, t0)" xsd:string ! schema ''Hepatitis viral''(time_t t0) = EVENT_STATE(''Hepatitis viral'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000623 name: Infective myositis def: "A disorder characterized by an infectious process involving the skeletal muscles OR An infectious process affecting the skeletal muscles. It can be caused by viruses (including HIV), bacteria, fungi, and parasites. Symptoms include muscle weakness and muscle pain." [NCI:CTCAE, NCIT:C26984] synonym: "Infectious myositis" EXACT [NCIT:C26984] xref: UMLS:C0158353 xref: NCI:CTCAE:10021918 xref: NCIT:C26984 property_value: ESCORT_rule "CCTO:000623 implies CCTO:000049" xsd:string ! ESCORT_rule ''Infective myositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000623 implies CCTO:001119" xsd:string ! ESCORT_rule ''Infective myositis'' implies ''Infections and infestations'' property_value: schema "CCTO:000623(time_t t0) = EVENT_STATE(CCTO:000623, t0)" xsd:string ! schema ''Infective myositis''(time_t t0) = EVENT_STATE(''Infective myositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000624 name: Joint infection def: "A disorder characterized by an infectious process involving a joint OR An infectious process affecting a joint. Causative agents include bacteria, viruses, fungi, and parasites." [NCI:CTCAE, NCIT:C78402] xref: UMLS:C0157749 xref: NCI:CTCAE:10023216 xref: NCIT:C78402 property_value: ESCORT_rule "CCTO:000624 implies CCTO:000049" xsd:string ! ESCORT_rule ''Joint infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000624 implies CCTO:001119" xsd:string ! ESCORT_rule ''Joint infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000624(time_t t0) = EVENT_STATE(CCTO:000624, t0)" xsd:string ! schema ''Joint infection''(time_t t0) = EVENT_STATE(''Joint infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000625 name: Kidney infection def: "A disorder characterized by an infectious process involving the kidney OR An acute or chronic inflammatory process affecting the kidney. It is caused by bacteria and in most cases it is the result of a urinary tract infection. Signs and symptoms include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion OR An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion." [NCI:CTCAE, NCIT:C79604, NCIT:C34965] synonym: "Pyelonephritis" EXACT [NCIT:C34965] synonym: "Pyelonephritis" EXACT [NCIT:C79604] xref: UMLS:C0034186 xref: UMLS:C0021313 xref: NCI:CTCAE:10023424 xref: NCIT:C34965 xref: NCIT:C79604 property_value: ESCORT_rule "CCTO:000625 implies CCTO:000049" xsd:string ! ESCORT_rule ''Kidney infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000625 implies CCTO:001119" xsd:string ! ESCORT_rule ''Kidney infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000625(time_t t0) = EVENT_STATE(CCTO:000625, t0)" xsd:string ! schema ''Kidney infection''(time_t t0) = EVENT_STATE(''Kidney infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000626 name: Laryngitis def: "An acute or chronic, bacterial or viral inflammatory process affecting the larynx. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness OR A disorder characterized by an inflammatory process involving the larynx OR An acute inflammatory process affecting the larynx. It is caused by bacteria, viruses, or vocal strain. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness." [NCIT:C26811, NCI:CTCAE, NCIT:C26688] synonym: "Acute laryngitis" EXACT [NCIT:C26688] synonym: "Laryngeal inflammation" EXACT [NCIT:C26811] xref: UMLS:C0023067 xref: UMLS:C0001327 xref: NCI:CTCAE:10023874 xref: NCI:CTCAE:10065735 xref: NCIT:C26688 xref: NCIT:C26811 property_value: ESCORT_rule "CCTO:000626 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000626 implies CCTO:001119" xsd:string ! ESCORT_rule ''Laryngitis'' implies ''Infections and infestations'' property_value: ESCORT_rule "CCTO:000626 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngitis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:000626(time_t t0) = EVENT_STATE(CCTO:000626, t0)" xsd:string ! schema ''Laryngitis''(time_t t0) = EVENT_STATE(''Laryngitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000627 name: Lip infection def: "An acute or chronic infectious process affecting the lips OR A disorder characterized by an infectious process involving the lips." [NCIT:C78434, NCI:CTCAE] xref: UMLS:C1698666 xref: NCI:CTCAE:10065755 xref: NCIT:C78434 property_value: ESCORT_rule "CCTO:000627 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lip infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000627 implies CCTO:001119" xsd:string ! ESCORT_rule ''Lip infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000627(time_t t0) = EVENT_STATE(CCTO:000627, t0)" xsd:string ! schema ''Lip infection''(time_t t0) = EVENT_STATE(''Lip infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000628 name: Lung infection def: "An acute or chronic infectious process affecting the lungs OR A disorder characterized by an infectious process involving the lungs." [NCIT:C26873, NCI:CTCAE] synonym: "Infectious lung disease" EXACT [NCIT:C26873] synonym: "Infectious lung diseases" EXACT [NCIT:C26873] synonym: "Infectious lung disorder" EXACT [NCIT:C26873] synonym: "Infectious lung disorders" EXACT [NCIT:C26873] xref: UMLS:C0876973 xref: NCI:CTCAE:10061229 xref: NCIT:C26873 property_value: ESCORT_rule "CCTO:000628 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lung infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000628 implies CCTO:001119" xsd:string ! ESCORT_rule ''Lung infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000628(time_t t0) = EVENT_STATE(CCTO:000628, t0)" xsd:string ! schema ''Lung infection''(time_t t0) = EVENT_STATE(''Lung infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000629 name: Lymph gland infection def: "A disorder characterized by an infectious process involving the lymph nodes OR Acute or chronic inflammation of one or more lymph nodes. It is usually caused by an infectious process." [NCI:CTCAE, NCIT:C26821] synonym: "Adenitis" EXACT [NCIT:C26821] synonym: "Lymphadenitis" EXACT [NCIT:C26821] xref: UMLS:C0024205 xref: UMLS:C0001416 xref: NCI:CTCAE:10050823 xref: NCIT:C26821 property_value: ESCORT_rule "CCTO:000629 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lymph gland infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000629 implies CCTO:001119" xsd:string ! ESCORT_rule ''Lymph gland infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000629(time_t t0) = EVENT_STATE(CCTO:000629, t0)" xsd:string ! schema ''Lymph gland infection''(time_t t0) = EVENT_STATE(''Lymph gland infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000630 name: Mediastinal infection def: "A disorder characterized by an infectious process involving the mediastinum OR An acute or chronic infectious process affecting the mediastinum." [NCI:CTCAE, NCIT:C83815] synonym: "Infectious mediastinitis" EXACT [NCIT:C83815] xref: UMLS:C0729554 xref: NCI:CTCAE:10057483 xref: NCIT:C83815 property_value: ESCORT_rule "CCTO:000630 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mediastinal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000630 implies CCTO:001119" xsd:string ! ESCORT_rule ''Mediastinal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000630(time_t t0) = EVENT_STATE(CCTO:000630, t0)" xsd:string ! schema ''Mediastinal infection''(time_t t0) = EVENT_STATE(''Mediastinal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000631 name: Meningitis def: "A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord OR A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord." [NCI:CTCAE, NCIT:C26828] xref: UMLS:C0025289 xref: UMLS:C0497299 xref: NCI:CTCAE:10027199 xref: NCIT:C26828 property_value: ESCORT_rule "CCTO:000631 implies CCTO:000049" xsd:string ! ESCORT_rule ''Meningitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000631 implies CCTO:001119" xsd:string ! ESCORT_rule ''Meningitis'' implies ''Infections and infestations'' property_value: schema "CCTO:000631(time_t t0) = EVENT_STATE(CCTO:000631, t0)" xsd:string ! schema ''Meningitis''(time_t t0) = EVENT_STATE(''Meningitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000632 name: Mucosal infection def: "A disorder characterized by an infectious process involving a mucosal surface OR An acute or chronic infectious process affecting a mucosal surface." [NCI:CTCAE, NCIT:C78454] xref: UMLS:C1698484 xref: NCI:CTCAE:10065764 xref: NCIT:C78454 property_value: ESCORT_rule "CCTO:000632 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mucosal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000632 implies CCTO:001119" xsd:string ! ESCORT_rule ''Mucosal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000632(time_t t0) = EVENT_STATE(CCTO:000632, t0)" xsd:string ! schema ''Mucosal infection''(time_t t0) = EVENT_STATE(''Mucosal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000633 name: Nail infection def: "An infectious process affecting the nail OR A disorder characterized by an infectious process involving the nail." [NCIT:C78493, NCI:CTCAE] xref: UMLS:C0343026 xref: NCI:CTCAE:10061304 xref: NCIT:C78493 property_value: ESCORT_rule "CCTO:000633 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nail infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000633 implies CCTO:001119" xsd:string ! ESCORT_rule ''Nail infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000633(time_t t0) = EVENT_STATE(CCTO:000633, t0)" xsd:string ! schema ''Nail infection''(time_t t0) = EVENT_STATE(''Nail infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000634 name: Ovarian infection def: "An infectious process affecting the ovary OR A disorder characterized by an infectious process involving the ovary." [NCIT:C78512, NCI:CTCAE] xref: UMLS:C0349735 xref: NCI:CTCAE:10055005 xref: NCIT:C78512 property_value: ESCORT_rule "CCTO:000634 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ovarian infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000634 implies CCTO:001119" xsd:string ! ESCORT_rule ''Ovarian infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000634(time_t t0) = EVENT_STATE(CCTO:000634, t0)" xsd:string ! schema ''Ovarian infection''(time_t t0) = EVENT_STATE(''Ovarian infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000635 name: Pancreas infection def: "An infectious process affecting the pancreas OR A disorder characterized by an infectious process involving the pancreas." [NCIT:C78517, NCI:CTCAE] synonym: "Pancreatic infection" EXACT [NCIT:C78517] xref: UMLS:C0948160 xref: NCI:CTCAE:10051741 xref: NCIT:C78517 property_value: ESCORT_rule "CCTO:000635 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreas infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000635 implies CCTO:001119" xsd:string ! ESCORT_rule ''Pancreas infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000635(time_t t0) = EVENT_STATE(CCTO:000635, t0)" xsd:string ! schema ''Pancreas infection''(time_t t0) = EVENT_STATE(''Pancreas infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000636 name: Papulopustular rash def: "Skin eruption consisting of papules and pustules, most often appearing in the face, scalp, and upper trunk. It is usually caused by corticosteroids or epidermal growth factor receptor inhibitors OR A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions." [NCIT:C80119, NCI:CTCAE] xref: UMLS:C2609319 xref: NCI:CTCAE:10069138 xref: NCIT:C80119 property_value: ESCORT_rule "CCTO:000636 implies CCTO:000049" xsd:string ! ESCORT_rule ''Papulopustular rash'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000636 implies CCTO:001119" xsd:string ! ESCORT_rule ''Papulopustular rash'' implies ''Infections and infestations'' property_value: schema "CCTO:000636(time_t t0) = EVENT_STATE(CCTO:000636, t0)" xsd:string ! schema ''Papulopustular rash''(time_t t0) = EVENT_STATE(''Papulopustular rash'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000637 name: Paronychia def: "An acute or chronic infection of the soft tissues around the nail. Symptoms include pain, tenderness, erythema, and swelling around the nail. Acute infection results from minor trauma to the fingertip and Staphylococcus aureus is usually the causative agent. Chronic infection is usually caused by Candida albicans OR A disorder characterized by an infectious process involving the soft tissues around the nail." [NCIT:C79702, NCI:CTCAE] xref: UMLS:C0030578 xref: UMLS:C1075202 xref: NCI:CTCAE:10034016 xref: NCIT:C79702 property_value: ESCORT_rule "CCTO:000637 implies CCTO:000049" xsd:string ! ESCORT_rule ''Paronychia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000637 implies CCTO:001119" xsd:string ! ESCORT_rule ''Paronychia'' implies ''Infections and infestations'' property_value: schema "CCTO:000637(time_t t0) = EVENT_STATE(CCTO:000637, t0)" xsd:string ! schema ''Paronychia''(time_t t0) = EVENT_STATE(''Paronychia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000638 name: Pelvic infection def: "Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection OR A disorder characterized by an infectious process involving the pelvic cavity." [NCIT:C3889, NCI:CTCAE] synonym: "Disease (PID), Pelvic Inflammatory" EXACT [NCIT:C3889] synonym: "Inflammatory Disease (PID), Pelvic" EXACT [NCIT:C3889] synonym: "PID" EXACT [NCIT:C3889] synonym: "PID, Pelvic Inflammatory Disease" EXACT [NCIT:C3889] synonym: "Pelvic inflammatory disease" EXACT [NCIT:C3889] synonym: "Pelvic Inflammatory Disease, (PID)" EXACT [NCIT:C3889] xref: UMLS:C0242172 xref: UMLS:C1417406 xref: UMLS:C0030790 xref: NCI:CTCAE:10058674 xref: NCIT:C3889 property_value: ESCORT_rule "CCTO:000638 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pelvic infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000638 implies CCTO:001119" xsd:string ! ESCORT_rule ''Pelvic infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000638(time_t t0) = EVENT_STATE(CCTO:000638, t0)" xsd:string ! schema ''Pelvic infection''(time_t t0) = EVENT_STATE(''Pelvic infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000639 name: Penile infection def: "A disorder characterized by an infectious process involving the penis OR An infectious process affecting the penis." [NCI:CTCAE, NCIT:C78526] xref: UMLS:C0581395 xref: NCI:CTCAE:10061912 xref: NCIT:C78526 property_value: ESCORT_rule "CCTO:000639 implies CCTO:000049" xsd:string ! ESCORT_rule ''Penile infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000639 implies CCTO:001119" xsd:string ! ESCORT_rule ''Penile infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000639(time_t t0) = EVENT_STATE(CCTO:000639, t0)" xsd:string ! schema ''Penile infection''(time_t t0) = EVENT_STATE(''Penile infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000640 name: Periorbital infection def: "An infectious process affecting the tissues around the orbit OR A disorder characterized by an infectious process involving the orbit of the eye." [NCIT:C78531, NCI:CTCAE] xref: UMLS:C0948065 xref: NCI:CTCAE:10051472 xref: NCIT:C78531 property_value: ESCORT_rule "CCTO:000640 implies CCTO:000049" xsd:string ! ESCORT_rule ''Periorbital infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000640 implies CCTO:001119" xsd:string ! ESCORT_rule ''Periorbital infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000640(time_t t0) = EVENT_STATE(CCTO:000640, t0)" xsd:string ! schema ''Periorbital infection''(time_t t0) = EVENT_STATE(''Periorbital infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000641 name: Peripheral nerve infection def: "A disorder characterized by an infectious process involving the peripheral nerves OR An infectious process affecting the peripheral nerves." [NCI:CTCAE, NCIT:C27589] synonym: "Peripheral nervous system infectious disorder" EXACT [NCIT:C27589] xref: UMLS:C1278821 xref: NCI:CTCAE:10065766 xref: NCIT:C27589 property_value: ESCORT_rule "CCTO:000641 implies CCTO:000049" xsd:string ! ESCORT_rule ''Peripheral nerve infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000641 implies CCTO:001119" xsd:string ! ESCORT_rule ''Peripheral nerve infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000641(time_t t0) = EVENT_STATE(CCTO:000641, t0)" xsd:string ! schema ''Peripheral nerve infection''(time_t t0) = EVENT_STATE(''Peripheral nerve infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000642 name: Peritoneal infection def: "An infectious process affecting the peritoneum OR A disorder characterized by an infectious process involving the peritoneum." [NCIT:C78540, NCI:CTCAE] xref: UMLS:C0851980 xref: NCI:CTCAE:10057262 xref: NCIT:C78540 property_value: ESCORT_rule "CCTO:000642 implies CCTO:000049" xsd:string ! ESCORT_rule ''Peritoneal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000642 implies CCTO:001119" xsd:string ! ESCORT_rule ''Peritoneal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000642(time_t t0) = EVENT_STATE(CCTO:000642, t0)" xsd:string ! schema ''Peritoneal infection''(time_t t0) = EVENT_STATE(''Peritoneal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000643 name: Pharyngitis def: "A disorder characterized by of marked discomfort in the throat OR Inflammation of the throat most often caused by viral and bacterial infections. Other causes include allergens, chemical substances, and trauma OR Any kind of inflammatory process of the tonsils, pharynx, or/and larynx characterized by pain in swallowing." [NCI:CTCAE, NCIT:C26851, NCIT:C50747] synonym: "Sore throat" EXACT [NCIT:C50747] synonym: "Throat, sore" EXACT [NCIT:C50747] xref: UMLS:C0242429 xref: UMLS:C0031350 xref: NCI:CTCAE:10034835 xref: NCI:CTCAE:10041367 xref: NCIT:C26851 xref: NCIT:C50747 property_value: ESCORT_rule "CCTO:000643 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000643 implies CCTO:001119" xsd:string ! ESCORT_rule ''Pharyngitis'' implies ''Infections and infestations'' property_value: ESCORT_rule "CCTO:000643 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngitis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:000643(time_t t0) = EVENT_STATE(CCTO:000643, t0)" xsd:string ! schema ''Pharyngitis''(time_t t0) = EVENT_STATE(''Pharyngitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000644 name: Phlebitis infective def: "A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein OR Infection at the site of needle puncture or intravenous catheter placement due to poor aseptic techniques. It is characterized by erythema, pain, swelling, and induration at the catheter insertion site." [NCI:CTCAE, NCIT:C78558] synonym: "Infective phlebitis" EXACT [NCIT:C78558] xref: UMLS:C1112243 xref: NCI:CTCAE:10056627 xref: NCIT:C78558 property_value: ESCORT_rule "CCTO:000644 implies CCTO:000049" xsd:string ! ESCORT_rule ''Phlebitis infective'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000644 implies CCTO:001119" xsd:string ! ESCORT_rule ''Phlebitis infective'' implies ''Infections and infestations'' property_value: schema "CCTO:000644(time_t t0) = EVENT_STATE(CCTO:000644, t0)" xsd:string ! schema ''Phlebitis infective''(time_t t0) = EVENT_STATE(''Phlebitis infective'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000645 name: Pleural infection def: "An infectious process affecting the pleura OR A disorder characterized by an infectious process involving the pleura." [NCIT:C78563, NCI:CTCAE] xref: UMLS:C0919907 xref: NCI:CTCAE:10061351 xref: NCIT:C78563 property_value: ESCORT_rule "CCTO:000645 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pleural infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000645 implies CCTO:001119" xsd:string ! ESCORT_rule ''Pleural infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000645(time_t t0) = EVENT_STATE(CCTO:000645, t0)" xsd:string ! schema ''Pleural infection''(time_t t0) = EVENT_STATE(''Pleural infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000646 name: Prostate infection def: "A disorder characterized by an infectious process involving the prostate gland OR An acute or chronic infectious process affecting the prostate gland." [NCI:CTCAE, NCIT:C27615] synonym: "Prostatic infection" EXACT [NCIT:C27615] xref: UMLS:C0240811 xref: NCI:CTCAE:10050662 xref: NCIT:C27615 property_value: ESCORT_rule "CCTO:000646 implies CCTO:000049" xsd:string ! ESCORT_rule ''Prostate infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000646 implies CCTO:001119" xsd:string ! ESCORT_rule ''Prostate infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000646(time_t t0) = EVENT_STATE(CCTO:000646, t0)" xsd:string ! schema ''Prostate infection''(time_t t0) = EVENT_STATE(''Prostate infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000647 name: Rash pustular def: "Elevated skin lesions associated with the presence of purulent material OR A disorder characterized by a circumscribed and elevated skin lesion filled with pus." [NCIT:C90597, NCI:CTCAE] synonym: "Pustular rash" EXACT [NCIT:C90597] xref: UMLS:C0085641 xref: NCI:CTCAE:10037888 xref: NCIT:C90597 property_value: ESCORT_rule "CCTO:000647 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rash pustular'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000647 implies CCTO:001119" xsd:string ! ESCORT_rule ''Rash pustular'' implies ''Infections and infestations'' property_value: schema "CCTO:000647(time_t t0) = EVENT_STATE(CCTO:000647, t0)" xsd:string ! schema ''Rash pustular''(time_t t0) = EVENT_STATE(''Rash pustular'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000648 name: Rhinitis infective def: "An inflammatory process affecting the nasal mucosa, usually caused by viruses (e.g., rhinovirus, adenovirus, parainfluenza virus, and coronavirus). It is characterized by chills, headaches, mucopurulent nasal discharge, coughing, and facial pain OR A disorder characterized by an infectious process involving the nasal mucosal." [NCIT:C78599, NCI:CTCAE] synonym: "Infectious rhinitis" EXACT [NCIT:C78599] synonym: "Non-allergic rhinitis" EXACT [NCIT:C78599] xref: UMLS:C0009443 xref: NCI:CTCAE:10059827 xref: NCIT:C78599 property_value: ESCORT_rule "CCTO:000648 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rhinitis infective'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000648 implies CCTO:001119" xsd:string ! ESCORT_rule ''Rhinitis infective'' implies ''Infections and infestations'' property_value: schema "CCTO:000648(time_t t0) = EVENT_STATE(CCTO:000648, t0)" xsd:string ! schema ''Rhinitis infective''(time_t t0) = EVENT_STATE(''Rhinitis infective'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000649 name: Salivary gland infection def: "A viral (such as mumps) or bacterial infectious process affecting the salivary gland. The salivary gland becomes enlarged and is often painful OR A disorder characterized by an infectious process involving the salivary gland." [NCIT:C78601, NCI:CTCAE] xref: UMLS:C0392318 xref: NCI:CTCAE:10039413 xref: NCIT:C78601 property_value: ESCORT_rule "CCTO:000649 implies CCTO:000049" xsd:string ! ESCORT_rule ''Salivary gland infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000649 implies CCTO:001119" xsd:string ! ESCORT_rule ''Salivary gland infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000649(time_t t0) = EVENT_STATE(CCTO:000649, t0)" xsd:string ! schema ''Salivary gland infection''(time_t t0) = EVENT_STATE(''Salivary gland infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000650 name: Scrotal infection def: "A disorder characterized by an infectious process involving the scrotum OR A bacterial, fungal or viral infectious process affecting the scrotum." [NCI:CTCAE, NCIT:C78606] xref: UMLS:C1299539 xref: NCI:CTCAE:10062156 xref: NCIT:C78606 property_value: ESCORT_rule "CCTO:000650 implies CCTO:000049" xsd:string ! ESCORT_rule ''Scrotal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000650 implies CCTO:001119" xsd:string ! ESCORT_rule ''Scrotal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000650(time_t t0) = EVENT_STATE(CCTO:000650, t0)" xsd:string ! schema ''Scrotal infection''(time_t t0) = EVENT_STATE(''Scrotal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000651 name: Sepsis def: "A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock OR The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention." [NCI:CTCAE, NCIT:C3364] synonym: "Sepsis syndrome" EXACT [NCIT:C3364] synonym: "Septicemia" EXACT [NCIT:C3364] synonym: "blood poisoning" EXACT [NCIT:C3364] synonym: "toxemia" EXACT [NCIT:C3364] xref: UMLS:C0036690 xref: UMLS:C0243026 xref: UMLS:C0242966 xref: UMLS:C0040524 xref: UMLS:C0542241 xref: NCI:CTCAE:10040047 xref: NCIT:C3364 property_value: ESCORT_rule "CCTO:000651 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sepsis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000651 implies CCTO:001119" xsd:string ! ESCORT_rule ''Sepsis'' implies ''Infections and infestations'' property_value: schema "CCTO:000651(time_t t0) = EVENT_STATE(CCTO:000651, t0)" xsd:string ! schema ''Sepsis''(time_t t0) = EVENT_STATE(''Sepsis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000652 name: Sinusitis def: "A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses OR An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity." [NCI:CTCAE, NCIT:C35024] xref: UMLS:C0037199 xref: NCI:CTCAE:10040753 xref: NCIT:C35024 property_value: ESCORT_rule "CCTO:000652 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sinusitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000652 implies CCTO:001119" xsd:string ! ESCORT_rule ''Sinusitis'' implies ''Infections and infestations'' property_value: schema "CCTO:000652(time_t t0) = EVENT_STATE(CCTO:000652, t0)" xsd:string ! schema ''Sinusitis''(time_t t0) = EVENT_STATE(''Sinusitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000653 name: Skin infection def: "An inflammatory process affecting the skin, caused by bacteria, viruses, parasites, or fungi. Examples of bacterial infection include carbuncles, furuncles, impetigo, erysipelas, and abscesses. Examples of viral infection include shingles, warts, molluscum contagiosum, and pityriasis rosea. Examples of parasitic infection include scabies and lice. Examples of fungal infection include athlete's foot, yeast infection, and ringworm OR A disorder characterized by an infectious process involving the skin." [NCIT:C35025, NCI:CTCAE] xref: UMLS:C0037278 xref: NCI:CTCAE:10040872 xref: NCIT:C35025 property_value: ESCORT_rule "CCTO:000653 implies CCTO:000049" xsd:string ! ESCORT_rule ''Skin infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000653 implies CCTO:001119" xsd:string ! ESCORT_rule ''Skin infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000653(time_t t0) = EVENT_STATE(CCTO:000653, t0)" xsd:string ! schema ''Skin infection''(time_t t0) = EVENT_STATE(''Skin infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000654 name: Small intestine infection def: "An infectious process affecting the small intestine OR A disorder characterized by an infectious process involving the small intestine." [NCIT:C78618, NCI:CTCAE] synonym: "Small intestinal infection" EXACT [NCIT:C78618] xref: UMLS:C1698036 xref: NCI:CTCAE:10065771 xref: NCIT:C78618 property_value: ESCORT_rule "CCTO:000654 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestine infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000654 implies CCTO:001119" xsd:string ! ESCORT_rule ''Small intestine infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000654(time_t t0) = EVENT_STATE(CCTO:000654, t0)" xsd:string ! schema ''Small intestine infection''(time_t t0) = EVENT_STATE(''Small intestine infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000655 name: Soft tissue infection def: "A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin OR A disorder characterized by an infectious process involving soft tissues." [NCIT:C79745, NCI:CTCAE] xref: UMLS:C0149778 xref: NCI:CTCAE:10062255 xref: NCIT:C79745 property_value: ESCORT_rule "CCTO:000655 implies CCTO:000049" xsd:string ! ESCORT_rule ''Soft tissue infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000655 implies CCTO:001119" xsd:string ! ESCORT_rule ''Soft tissue infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000655(time_t t0) = EVENT_STATE(CCTO:000655, t0)" xsd:string ! schema ''Soft tissue infection''(time_t t0) = EVENT_STATE(''Soft tissue infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000656 name: Splenic infection def: "An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi OR A disorder characterized by an infectious process involving the spleen." [NCIT:C78627, NCI:CTCAE] xref: UMLS:C0948149 xref: NCI:CTCAE:10062112 xref: NCIT:C78627 property_value: ESCORT_rule "CCTO:000656 implies CCTO:000049" xsd:string ! ESCORT_rule ''Splenic infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000656 implies CCTO:001119" xsd:string ! ESCORT_rule ''Splenic infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000656(time_t t0) = EVENT_STATE(CCTO:000656, t0)" xsd:string ! schema ''Splenic infection''(time_t t0) = EVENT_STATE(''Splenic infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000657 name: Stoma site infection def: "A disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body) OR An infectious process affecting a surgically created opening in the surface of the body." [NCI:CTCAE, NCIT:C78629] xref: UMLS:C1610624 xref: NCI:CTCAE:10064505 xref: NCIT:C78629 property_value: ESCORT_rule "CCTO:000657 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stoma site infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000657 implies CCTO:001119" xsd:string ! ESCORT_rule ''Stoma site infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000657(time_t t0) = EVENT_STATE(CCTO:000657, t0)" xsd:string ! schema ''Stoma site infection''(time_t t0) = EVENT_STATE(''Stoma site infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000658 name: Tooth infection def: "An infectious process affecting a tooth OR A disorder characterized by an infectious process involving a tooth." [NCIT:C78639, NCI:CTCAE] synonym: "Dental infection" EXACT [NCIT:C78639] xref: UMLS:C0877046 xref: NCI:CTCAE:10048762 xref: NCIT:C78639 property_value: ESCORT_rule "CCTO:000658 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tooth infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000658 implies CCTO:001119" xsd:string ! ESCORT_rule ''Tooth infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000658(time_t t0) = EVENT_STATE(CCTO:000658, t0)" xsd:string ! schema ''Tooth infection''(time_t t0) = EVENT_STATE(''Tooth infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000659 name: Tracheitis def: "An inflammatory process affecting the wall of the trachea OR Bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella OR A disorder characterized by an infectious process involving the trachea." [NCIT:C78643, NCIT:C78647, NCI:CTCAE] synonym: "Bacterial tracheitis" EXACT [NCIT:C78647] synonym: "Tracheal inflammation" EXACT [NCIT:C78643] xref: UMLS:C1868703 xref: UMLS:C0040584 xref: UMLS:C1697280 xref: NCI:CTCAE:10044302 xref: NCIT:C78643 xref: NCIT:C78647 property_value: ESCORT_rule "CCTO:000659 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000659 implies CCTO:001119" xsd:string ! ESCORT_rule ''Tracheitis'' implies ''Infections and infestations'' property_value: schema "CCTO:000659(time_t t0) = EVENT_STATE(CCTO:000659, t0)" xsd:string ! schema ''Tracheitis''(time_t t0) = EVENT_STATE(''Tracheitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000660 name: Upper respiratory infection def: "A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea) OR An infectious process affecting the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea). Symptoms include congestion, sneezing, coughing, fever, and sore throat." [NCI:CTCAE, NCIT:C35650] synonym: "Cold" EXACT [NCIT:C35650] synonym: "Infection, upper respiratory tract" EXACT [NCIT:C35650] synonym: "Upper respiratory tract infection" EXACT [NCIT:C35650] synonym: "Upper respiratory tract inflammation" EXACT [NCIT:C35650] xref: UMLS:C0041912 xref: UMLS:C0877266 xref: UMLS:C0009443 xref: UMLS:C0234192 xref: UMLS:C0024117 xref: NCI:CTCAE:10046300 xref: NCIT:C35650 property_value: ESCORT_rule "CCTO:000660 implies CCTO:000049" xsd:string ! ESCORT_rule ''Upper respiratory infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000660 implies CCTO:001119" xsd:string ! ESCORT_rule ''Upper respiratory infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000660(time_t t0) = EVENT_STATE(CCTO:000660, t0)" xsd:string ! schema ''Upper respiratory infection''(time_t t0) = EVENT_STATE(''Upper respiratory infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000661 name: Urethral infection def: "A disorder characterized by an infectious process involving the urethra OR A bacterial, viral, or fungal infectious process affecting the urethra." [NCI:CTCAE, NCIT:C78671] xref: UMLS:C0948357 xref: NCI:CTCAE:10052298 xref: NCIT:C78671 property_value: ESCORT_rule "CCTO:000661 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urethral infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000661 implies CCTO:001119" xsd:string ! ESCORT_rule ''Urethral infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000661(time_t t0) = EVENT_STATE(CCTO:000661, t0)" xsd:string ! schema ''Urethral infection''(time_t t0) = EVENT_STATE(''Urethral infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000662 name: Urinary tract infection def: "A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra OR A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine." [NCI:CTCAE, NCIT:C50791] synonym: "Infection, urinary tract" EXACT [NCIT:C50791] synonym: "Tract, infection of urinary" EXACT [NCIT:C50791] synonym: "UTI" EXACT [NCIT:C50791] synonym: "Urinary tract infectious disease" EXACT [NCIT:C50791] xref: UMLS:C0042029 xref: NCI:CTCAE:10046571 xref: NCIT:C50791 property_value: ESCORT_rule "CCTO:000662 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary tract infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000662 implies CCTO:001119" xsd:string ! ESCORT_rule ''Urinary tract infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000662(time_t t0) = EVENT_STATE(CCTO:000662, t0)" xsd:string ! schema ''Urinary tract infection''(time_t t0) = EVENT_STATE(''Urinary tract infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000663 name: Uterine infection def: "An acute or chronic, usually bacterial infectious process affecting the endometrium. It may extend to the myometrium and parametrial tissues. Symptoms include lower abdominal pain, vaginal discharge, and vaginal bleeding OR A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues." [NCIT:C26764, NCI:CTCAE] synonym: "Endometritis" EXACT [NCIT:C26764] xref: UMLS:C0014179 xref: UMLS:C0042136 xref: NCI:CTCAE:10062233 xref: NCIT:C26764 property_value: ESCORT_rule "CCTO:000663 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uterine infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000663 implies CCTO:001119" xsd:string ! ESCORT_rule ''Uterine infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000663(time_t t0) = EVENT_STATE(CCTO:000663, t0)" xsd:string ! schema ''Uterine infection''(time_t t0) = EVENT_STATE(''Uterine infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000664 name: Vaginal infection def: "An infectious process affecting the vagina. Symptoms include pain and purulent discharge OR A disorder characterized by an infectious process involving the vagina." [NCIT:C84353, NCI:CTCAE] xref: UMLS:C0404521 xref: NCI:CTCAE:10046914 xref: NCIT:C84353 property_value: ESCORT_rule "CCTO:000664 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000664 implies CCTO:001119" xsd:string ! ESCORT_rule ''Vaginal infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000664(time_t t0) = EVENT_STATE(CCTO:000664, t0)" xsd:string ! schema ''Vaginal infection''(time_t t0) = EVENT_STATE(''Vaginal infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000665 name: Vulval infection def: "A disorder characterized by an infectious process involving the vulva OR An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge." [NCI:CTCAE, NCIT:C78716] xref: UMLS:C1699561 xref: NCI:CTCAE:10065772 xref: NCIT:C78716 property_value: ESCORT_rule "CCTO:000665 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vulval infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000665 implies CCTO:001119" xsd:string ! ESCORT_rule ''Vulval infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000665(time_t t0) = EVENT_STATE(CCTO:000665, t0)" xsd:string ! schema ''Vulval infection''(time_t t0) = EVENT_STATE(''Vulval infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000666 name: Wound infection def: "Infection of a break in the skin or other tissue OR A disorder characterized by an infectious process involving the wound." [NCIT:C45234, NCI:CTCAE] xref: UMLS:C0043241 xref: NCI:CTCAE:10048038 xref: NCIT:C45234 property_value: ESCORT_rule "CCTO:000666 implies CCTO:000049" xsd:string ! ESCORT_rule ''Wound infection'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000666 implies CCTO:001119" xsd:string ! ESCORT_rule ''Wound infection'' implies ''Infections and infestations'' property_value: schema "CCTO:000666(time_t t0) = EVENT_STATE(CCTO:000666, t0)" xsd:string ! schema ''Wound infection''(time_t t0) = EVENT_STATE(''Wound infection'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001119 ! Infections and infestations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000667 name: Ankle fracture def: "Traumatic or pathological injury to the ankle joint in which the continuity of an ankle bone is broken. Symptoms include pain, swelling, and difficulty moving the affected leg and foot OR A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot." [NCIT:C26989, NCI:CTCAE] xref: UMLS:C0159877 xref: NCI:CTCAE:10002544 xref: NCIT:C26989 property_value: ESCORT_rule "CCTO:000667 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ankle fracture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000667 implies CCTO:001120" xsd:string ! ESCORT_rule ''Ankle fracture'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000667(time_t t0) = EVENT_STATE(CCTO:000667, t0)" xsd:string ! schema ''Ankle fracture''(time_t t0) = EVENT_STATE(''Ankle fracture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000668 name: Aortic injury def: "A finding of damage to the aorta OR Damage to the aorta from traumatic or pathologic processes." [NCI:CTCAE, NCIT:C35623] xref: UMLS:C0854391 xref: NCI:CTCAE:10002899 xref: NCIT:C35623 property_value: ESCORT_rule "CCTO:000668 implies CCTO:000049" xsd:string ! ESCORT_rule ''Aortic injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000668 implies CCTO:001120" xsd:string ! ESCORT_rule ''Aortic injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000668(time_t t0) = EVENT_STATE(CCTO:000668, t0)" xsd:string ! schema ''Aortic injury''(time_t t0) = EVENT_STATE(''Aortic injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000669 name: Arterial injury def: "A finding of damage to an artery OR Damage to an artery from traumatic or pathologic processes." [NCI:CTCAE, NCIT:C35401] xref: UMLS:C0340652 xref: NCI:CTCAE:10003162 xref: NCIT:C35401 property_value: ESCORT_rule "CCTO:000669 implies CCTO:000049" xsd:string ! ESCORT_rule ''Arterial injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000669 implies CCTO:001120" xsd:string ! ESCORT_rule ''Arterial injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000669(time_t t0) = EVENT_STATE(CCTO:000669, t0)" xsd:string ! schema ''Arterial injury''(time_t t0) = EVENT_STATE(''Arterial injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000670 name: Biliary anastomotic leak def: "Leakage of bile due to breakdown of a biliary anastomosis OR A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78183, NCI:CTCAE] synonym: "Biliary anastomotic leakage" EXACT [NCIT:C78183] xref: UMLS:C0401006 xref: NCI:CTCAE:10050458 xref: NCIT:C78183 property_value: ESCORT_rule "CCTO:000670 implies CCTO:000049" xsd:string ! ESCORT_rule ''Biliary anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000670 implies CCTO:001120" xsd:string ! ESCORT_rule ''Biliary anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000670(time_t t0) = EVENT_STATE(CCTO:000670, t0)" xsd:string ! schema ''Biliary anastomotic leak''(time_t t0) = EVENT_STATE(''Biliary anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000671 name: Bladder anastomotic leak def: "Leakage of urine due to breakdown of a bladder anastomosis OR A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78206, NCI:CTCAE] synonym: "Bladder anastomotic leakage" EXACT [NCIT:C78206] xref: UMLS:C1697974 xref: NCI:CTCAE:10065802 xref: NCIT:C78206 property_value: ESCORT_rule "CCTO:000671 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bladder anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000671 implies CCTO:001120" xsd:string ! ESCORT_rule ''Bladder anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000671(time_t t0) = EVENT_STATE(CCTO:000671, t0)" xsd:string ! schema ''Bladder anastomotic leak''(time_t t0) = EVENT_STATE(''Bladder anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000672 name: Bruising def: "A finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues OR Injury of the soft tissues or bone without breaking the skin that is characterized by blood leakage into the surrounding area." [NCI:CTCAE, NCIT:C37921] synonym: "Bruise" EXACT [NCIT:C37921] xref: UMLS:C0009938 xref: UMLS:C3812660 xref: NCI:CTCAE:10006504 xref: NCIT:C37921 property_value: ESCORT_rule "CCTO:000672 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bruising'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000672 implies CCTO:001120" xsd:string ! ESCORT_rule ''Bruising'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000672(time_t t0) = EVENT_STATE(CCTO:000672, t0)" xsd:string ! schema ''Bruising''(time_t t0) = EVENT_STATE(''Bruising'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000673 name: Burn def: "A traumatic injury involving interruption of tissue cohesiveness that results from exposure to caustic chemicals, extreme heat, extreme cold or excessive radiation OR A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment." [NCIT:C34441, NCI:CTCAE] synonym: "Burn adverse event" EXACT [NCIT:C57900] synonym: "Burn of device or device component" EXACT [NCIT:C63286] synonym: "Burn(s)" EXACT [NCIT:C34441] synonym: "Burned Medical Device or Device Component" EXACT [NCIT:C63286] synonym: "Burned" EXACT [NCIT:C63286] synonym: "Burnt" EXACT [NCIT:C63286] xref: UMLS:C0006434 xref: UMLS:C1879905 xref: UMLS:C1962979 xref: NCI:CTCAE:10006634 xref: NCIT:C34441 xref: NCIT:C57900 xref: NCIT:C63286 property_value: ESCORT_rule "CCTO:000673 implies CCTO:000049" xsd:string ! ESCORT_rule ''Burn'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000673 implies CCTO:001120" xsd:string ! ESCORT_rule ''Burn'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000673(time_t t0) = EVENT_STATE(CCTO:000673, t0)" xsd:string ! schema ''Burn''(time_t t0) = EVENT_STATE(''Burn'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000674 name: Dermatitis radiation def: "A finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation OR A cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation." [NCI:CTCAE, NCIT:C3349] synonym: "Radiation dermatitis" EXACT [NCIT:C3349] synonym: "Radiation-induced dermatitis" EXACT [NCIT:C3349] synonym: "Radiodermatitis" EXACT [NCIT:C3349] xref: UMLS:C0034561 xref: NCI:CTCAE:10061103 xref: NCIT:C3349 property_value: ESCORT_rule "CCTO:000674 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dermatitis radiation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000674 implies CCTO:001120" xsd:string ! ESCORT_rule ''Dermatitis radiation'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000674(time_t t0) = EVENT_STATE(CCTO:000674, t0)" xsd:string ! schema ''Dermatitis radiation''(time_t t0) = EVENT_STATE(''Dermatitis radiation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000675 name: Esophageal anastomotic leak def: "Leakage due to breakdown of an esophageal anastomosis OR A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78270, NCI:CTCAE] synonym: "Esophageal anastomotic leakage" EXACT [NCIT:C78270] xref: UMLS:C0341563 xref: NCI:CTCAE:10065961 xref: NCIT:C78270 property_value: ESCORT_rule "CCTO:000675 implies CCTO:000049" xsd:string ! ESCORT_rule ''Esophageal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000675 implies CCTO:001120" xsd:string ! ESCORT_rule ''Esophageal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000675(time_t t0) = EVENT_STATE(CCTO:000675, t0)" xsd:string ! schema ''Esophageal anastomotic leak''(time_t t0) = EVENT_STATE(''Esophageal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000676 name: Fall def: "A finding of sudden movement downward, usually resulting in injury OR The season between the autumnal equinox and the winter solstice OR A sudden movement downward, usually resulting in injury." [NCI:CTCAE, NCIT:C94733, NCIT:C50558] synonym: "Autumn" EXACT [NCIT:C94733] xref: UMLS:C0085639 xref: UMLS:C0238715 xref: NCI:CTCAE:10016173 xref: NCIT:C50558 xref: NCIT:C94733 property_value: ESCORT_rule "CCTO:000676 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fall'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000676 implies CCTO:001120" xsd:string ! ESCORT_rule ''Fall'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000676(time_t t0) = EVENT_STATE(CCTO:000676, t0)" xsd:string ! schema ''Fall''(time_t t0) = EVENT_STATE(''Fall'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000677 name: Fallopian tube anastomotic leak def: "A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a fallopian tube anastomosis." [NCI:CTCAE, NCIT:C78292] synonym: "Fallopian tube anastomotic leakage" EXACT [NCIT:C78292] xref: UMLS:C1698039 xref: NCI:CTCAE:10065788 xref: NCIT:C78292 property_value: ESCORT_rule "CCTO:000677 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fallopian tube anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000677 implies CCTO:001120" xsd:string ! ESCORT_rule ''Fallopian tube anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000677(time_t t0) = EVENT_STATE(CCTO:000677, t0)" xsd:string ! schema ''Fallopian tube anastomotic leak''(time_t t0) = EVENT_STATE(''Fallopian tube anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000678 name: Fallopian tube perforation def: "A finding of rupture of the fallopian tube wall OR A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78294] synonym: "Fallopian tube perforation adverse event" EXACT [NCIT:C57060] xref: UMLS:C1557983 xref: UMLS:C1963109 xref: NCI:CTCAE:10065790 xref: NCIT:C57060 xref: NCIT:C78294 property_value: ESCORT_rule "CCTO:000678 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fallopian tube perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000678 implies CCTO:001120" xsd:string ! ESCORT_rule ''Fallopian tube perforation'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000678(time_t t0) = EVENT_STATE(CCTO:000678, t0)" xsd:string ! schema ''Fallopian tube perforation''(time_t t0) = EVENT_STATE(''Fallopian tube perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000679 name: Fracture def: "A finding of traumatic injury to the bone in which the continuity of the bone is broken OR A traumatic injury to the bone in which the continuity of the bone is broken." [NCI:CTCAE, NCIT:C3046] synonym: "Bone fracture" EXACT [NCIT:C3046] synonym: "Fracture adverse event" EXACT [NCIT:C58382] synonym: "Fracture of Bone" EXACT [NCIT:C3046] synonym: "Fracture of Medical Device Material" EXACT [NCIT:C63132] synonym: "Fracture(s) Of Device/Material" EXACT [NCIT:C63132] synonym: "Fracture(s)" EXACT [NCIT:C3046] xref: UMLS:C0016658 xref: UMLS:C1963113 xref: UMLS:C1880851 xref: NCI:CTCAE:10017076 xref: NCIT:C3046 xref: NCIT:C58382 xref: NCIT:C63132 property_value: ESCORT_rule "CCTO:000679 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fracture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000679 implies CCTO:001120" xsd:string ! ESCORT_rule ''Fracture'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000679(time_t t0) = EVENT_STATE(CCTO:000679, t0)" xsd:string ! schema ''Fracture''(time_t t0) = EVENT_STATE(''Fracture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000680 name: Gastric anastomotic leak def: "A finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a gastric anastomosis." [NCI:CTCAE, NCIT:C78310] synonym: "Gastric anastomotic leakage" EXACT [NCIT:C78310] xref: UMLS:C0341564 xref: NCI:CTCAE:10065893 xref: NCIT:C78310 property_value: ESCORT_rule "CCTO:000680 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastric anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000680 implies CCTO:001120" xsd:string ! ESCORT_rule ''Gastric anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000680(time_t t0) = EVENT_STATE(CCTO:000680, t0)" xsd:string ! schema ''Gastric anastomotic leak''(time_t t0) = EVENT_STATE(''Gastric anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000681 name: Gastrointestinal anastomotic leak def: "A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a gastrointestinal anastomosis." [NCI:CTCAE, NCIT:C78318] synonym: "Digestive system anastomotic leakage" EXACT [NCIT:C78318] synonym: "Gastrointestinal system anastomotic leakage" EXACT [NCIT:C78318] xref: UMLS:C0341562 xref: NCI:CTCAE:10065879 xref: NCIT:C78318 property_value: ESCORT_rule "CCTO:000681 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastrointestinal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000681 implies CCTO:001120" xsd:string ! ESCORT_rule ''Gastrointestinal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000681(time_t t0) = EVENT_STATE(CCTO:000681, t0)" xsd:string ! schema ''Gastrointestinal anastomotic leak''(time_t t0) = EVENT_STATE(''Gastrointestinal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000682 name: Gastrointestinal stoma necrosis def: "A finding of a necrotic process occurring in the gastrointestinal tract stoma OR A necrotic process affecting the post-operative stoma area in the gastrointestinal tract." [NCI:CTCAE, NCIT:C78321] synonym: "Gastrointestinal stoma necrotic lesion" EXACT [NCIT:C78321] xref: UMLS:C1698678 xref: NCI:CTCAE:10065712 xref: NCIT:C78321 property_value: ESCORT_rule "CCTO:000682 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gastrointestinal stoma necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000682 implies CCTO:001120" xsd:string ! ESCORT_rule ''Gastrointestinal stoma necrosis'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000682(time_t t0) = EVENT_STATE(CCTO:000682, t0)" xsd:string ! schema ''Gastrointestinal stoma necrosis''(time_t t0) = EVENT_STATE(''Gastrointestinal stoma necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000683 name: Hip fracture def: "A traumatic break in one or more of the bones that compose the bony structure of the pelvis OR A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken OR Traumatic or pathological injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. Symptoms include pain in the hip or groin, bruising and swelling in and around the hip area. The injured hip is turned outward and the leg appears shorter on that side." [NCIT:C35153, NCI:CTCAE, NCIT:C26794] synonym: "Fracture of Pelvis" EXACT [NCIT:C35153] synonym: "Fracture, hip" EXACT [NCIT:C26794] xref: UMLS:C0019557 xref: UMLS:C0149531 xref: NCI:CTCAE:10020100 xref: NCIT:C26794 xref: NCIT:C35153 property_value: ESCORT_rule "CCTO:000683 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hip fracture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000683 implies CCTO:001120" xsd:string ! ESCORT_rule ''Hip fracture'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000683(time_t t0) = EVENT_STATE(CCTO:000683, t0)" xsd:string ! schema ''Hip fracture''(time_t t0) = EVENT_STATE(''Hip fracture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000684 name: Injury to carotid artery def: "Damage to the carotid artery. Causes include blunt injuries (e.g., motor vehicle accidents and sports-related injuries) and penetrating traumas (e.g., gunshot and knife injuries) OR A finding of damage to the carotid artery." [NCIT:C79599, NCI:CTCAE] xref: UMLS:C0160680 xref: NCI:CTCAE:10022161 xref: NCIT:C79599 property_value: ESCORT_rule "CCTO:000684 implies CCTO:000049" xsd:string ! ESCORT_rule ''Injury to carotid artery'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000684 implies CCTO:001120" xsd:string ! ESCORT_rule ''Injury to carotid artery'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000684(time_t t0) = EVENT_STATE(CCTO:000684, t0)" xsd:string ! schema ''Injury to carotid artery''(time_t t0) = EVENT_STATE(''Injury to carotid artery'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000685 name: Injury to inferior vena cava def: "Damage to the inferior vena cava from traumatic or pathologic processes OR A finding of damage to the inferior vena cava." [NCIT:C78363, NCI:CTCAE] xref: UMLS:C0160705 xref: NCI:CTCAE:10022213 xref: NCIT:C78363 property_value: ESCORT_rule "CCTO:000685 implies CCTO:000049" xsd:string ! ESCORT_rule ''Injury to inferior vena cava'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000685 implies CCTO:001120" xsd:string ! ESCORT_rule ''Injury to inferior vena cava'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000685(time_t t0) = EVENT_STATE(CCTO:000685, t0)" xsd:string ! schema ''Injury to inferior vena cava''(time_t t0) = EVENT_STATE(''Injury to inferior vena cava'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000686 name: Injury to jugular vein def: "Damage to the jugular vein from traumatic or pathologic processes OR A finding of damage to the jugular vein." [NCIT:C78364, NCI:CTCAE] xref: UMLS:C0347703 xref: NCI:CTCAE:10065849 xref: NCIT:C78364 property_value: ESCORT_rule "CCTO:000686 implies CCTO:000049" xsd:string ! ESCORT_rule ''Injury to jugular vein'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000686 implies CCTO:001120" xsd:string ! ESCORT_rule ''Injury to jugular vein'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000686(time_t t0) = EVENT_STATE(CCTO:000686, t0)" xsd:string ! schema ''Injury to jugular vein''(time_t t0) = EVENT_STATE(''Injury to jugular vein'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000687 name: Injury to superior vena cava def: "Damage to the superior vena cava from traumatic or pathologic processes OR A finding of damage to the superior vena cava." [NCIT:C78365, NCI:CTCAE] xref: UMLS:C0160692 xref: NCI:CTCAE:10022356 xref: NCIT:C78365 property_value: ESCORT_rule "CCTO:000687 implies CCTO:000049" xsd:string ! ESCORT_rule ''Injury to superior vena cava'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000687 implies CCTO:001120" xsd:string ! ESCORT_rule ''Injury to superior vena cava'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000687(time_t t0) = EVENT_STATE(CCTO:000687, t0)" xsd:string ! schema ''Injury to superior vena cava''(time_t t0) = EVENT_STATE(''Injury to superior vena cava'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000688 name: Intestinal stoma leak def: "Leakage of contents from the intestinal stoma OR A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body)." [NCIT:C78369, NCI:CTCAE] synonym: "Intestinal stoma leakage" EXACT [NCIT:C78369] xref: UMLS:C1142488 xref: NCI:CTCAE:10059095 xref: NCIT:C78369 property_value: ESCORT_rule "CCTO:000688 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intestinal stoma leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000688 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intestinal stoma leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000688(time_t t0) = EVENT_STATE(CCTO:000688, t0)" xsd:string ! schema ''Intestinal stoma leak''(time_t t0) = EVENT_STATE(''Intestinal stoma leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000689 name: Intestinal stoma obstruction def: "A finding of blockage of the normal flow of the contents of the intestinal stoma OR A blockage of the intestinal stoma." [NCI:CTCAE, NCIT:C78370] xref: UMLS:C1142487 xref: NCI:CTCAE:10059094 xref: NCIT:C78370 property_value: ESCORT_rule "CCTO:000689 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intestinal stoma obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000689 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intestinal stoma obstruction'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000689(time_t t0) = EVENT_STATE(CCTO:000689, t0)" xsd:string ! schema ''Intestinal stoma obstruction''(time_t t0) = EVENT_STATE(''Intestinal stoma obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000690 name: Intestinal stoma site bleeding def: "A finding of blood leakage from the intestinal stoma OR A finding of blood leakage from the intestinal stoma." [NCI:CTCAE, NCIT:C78371] synonym: "Intestinal stoma site hemorrhage" EXACT [NCIT:C78371] xref: UMLS:C0877223 xref: NCI:CTCAE:10049468 xref: NCIT:C78371 property_value: ESCORT_rule "CCTO:000690 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intestinal stoma site bleeding'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000690 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intestinal stoma site bleeding'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000690(time_t t0) = EVENT_STATE(CCTO:000690, t0)" xsd:string ! schema ''Intestinal stoma site bleeding''(time_t t0) = EVENT_STATE(''Intestinal stoma site bleeding'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000691 name: Intraoperative arterial injury def: "Damage to an artery during a surgical procedure OR A finding of damage to an artery during a surgical procedure." [NCIT:C78375, NCI:CTCAE] xref: UMLS:C1698098 xref: NCI:CTCAE:10065826 xref: NCIT:C78375 property_value: ESCORT_rule "CCTO:000691 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative arterial injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000691 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative arterial injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000691(time_t t0) = EVENT_STATE(CCTO:000691, t0)" xsd:string ! schema ''Intraoperative arterial injury''(time_t t0) = EVENT_STATE(''Intraoperative arterial injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000692 name: Intraoperative breast injury def: "A finding of damage to the breast parenchyma during a surgical procedure OR Damage to the breast parenchyma during a surgical procedure." [NCI:CTCAE, NCIT:C78376] xref: UMLS:C1558321 xref: NCI:CTCAE:10065831 xref: NCIT:C78376 property_value: ESCORT_rule "CCTO:000692 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative breast injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000692 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative breast injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000692(time_t t0) = EVENT_STATE(CCTO:000692, t0)" xsd:string ! schema ''Intraoperative breast injury''(time_t t0) = EVENT_STATE(''Intraoperative breast injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000693 name: Intraoperative cardiac injury def: "Damage to the heart during a surgical procedure OR A finding of damage to the heart during a surgical procedure." [NCIT:C78377, NCI:CTCAE] xref: UMLS:C1699742 xref: NCI:CTCAE:10065843 xref: NCIT:C78377 property_value: ESCORT_rule "CCTO:000693 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative cardiac injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000693 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative cardiac injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000693(time_t t0) = EVENT_STATE(CCTO:000693, t0)" xsd:string ! schema ''Intraoperative cardiac injury''(time_t t0) = EVENT_STATE(''Intraoperative cardiac injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000694 name: Intraoperative ear injury def: "A finding of damage to the ear during a surgical procedure OR Damage to the ear during a surgical procedure." [NCI:CTCAE, NCIT:C78378] xref: UMLS:C1699211 xref: NCI:CTCAE:10065844 xref: NCIT:C78378 property_value: ESCORT_rule "CCTO:000694 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative ear injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000694 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative ear injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000694(time_t t0) = EVENT_STATE(CCTO:000694, t0)" xsd:string ! schema ''Intraoperative ear injury''(time_t t0) = EVENT_STATE(''Intraoperative ear injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000695 name: Intraoperative endocrine injury def: "Damage to an endocrine gland during a surgical procedure OR A finding of damage to the endocrine gland during a surgical procedure." [NCIT:C78379, NCI:CTCAE] xref: UMLS:C1699738 xref: NCI:CTCAE:10065834 xref: NCIT:C78379 property_value: ESCORT_rule "CCTO:000695 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative endocrine injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000695 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative endocrine injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000695(time_t t0) = EVENT_STATE(CCTO:000695, t0)" xsd:string ! schema ''Intraoperative endocrine injury''(time_t t0) = EVENT_STATE(''Intraoperative endocrine injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000696 name: Intraoperative gastrointestinal injury def: "A finding of damage to the gastrointestinal system during a surgical procedure OR Damage to any part of the digestive system during a surgical procedure." [NCI:CTCAE, NCIT:C78380] synonym: "Intraoperative digestive system injury" EXACT [NCIT:C78380] xref: UMLS:C1698097 xref: NCI:CTCAE:10065825 xref: NCIT:C78380 property_value: ESCORT_rule "CCTO:000696 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative gastrointestinal injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000696 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative gastrointestinal injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000696(time_t t0) = EVENT_STATE(CCTO:000696, t0)" xsd:string ! schema ''Intraoperative gastrointestinal injury''(time_t t0) = EVENT_STATE(''Intraoperative gastrointestinal injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000697 name: Intraoperative head and neck injury def: "Damage to head and neck during a surgical procedure OR A finding of damage to the head and neck during a surgical procedure." [NCIT:C78381, NCI:CTCAE] xref: UMLS:C1699741 xref: NCI:CTCAE:10065842 xref: NCIT:C78381 property_value: ESCORT_rule "CCTO:000697 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative head and neck injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000697 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative head and neck injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000697(time_t t0) = EVENT_STATE(CCTO:000697, t0)" xsd:string ! schema ''Intraoperative head and neck injury''(time_t t0) = EVENT_STATE(''Intraoperative head and neck injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000698 name: Intraoperative hemorrhage def: "A finding of uncontrolled bleeding during a surgical procedure OR Uncontrolled bleeding during a surgical procedure." [NCI:CTCAE, NCIT:C35135] synonym: "Operative hemorrhage" EXACT [NCIT:C35135] xref: UMLS:C0079027 xref: NCI:CTCAE:10055298 xref: NCIT:C35135 xref: NCIT:C79600 property_value: ESCORT_rule "CCTO:000698 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000698 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative hemorrhage'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000698(time_t t0) = EVENT_STATE(CCTO:000698, t0)" xsd:string ! schema ''Intraoperative hemorrhage''(time_t t0) = EVENT_STATE(''Intraoperative hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000699 name: Intraoperative hepatobiliary injury def: "A finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure OR Damage to the hepatic parenchyma and biliary tract during a surgical procedure." [NCI:CTCAE, NCIT:C78382] xref: UMLS:C1699208 xref: NCI:CTCAE:10065827 xref: NCIT:C78382 property_value: ESCORT_rule "CCTO:000699 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative hepatobiliary injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000699 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative hepatobiliary injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000699(time_t t0) = EVENT_STATE(CCTO:000699, t0)" xsd:string ! schema ''Intraoperative hepatobiliary injury''(time_t t0) = EVENT_STATE(''Intraoperative hepatobiliary injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000700 name: Intraoperative musculoskeletal injury def: "Damage to any part of the musculoskeletal system during a surgical procedure OR A finding of damage to the musculoskeletal system during a surgical procedure." [NCIT:C78383, NCI:CTCAE] xref: UMLS:C1699209 xref: NCI:CTCAE:10065829 xref: NCIT:C78383 property_value: ESCORT_rule "CCTO:000700 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative musculoskeletal injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000700 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative musculoskeletal injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000700(time_t t0) = EVENT_STATE(CCTO:000700, t0)" xsd:string ! schema ''Intraoperative musculoskeletal injury''(time_t t0) = EVENT_STATE(''Intraoperative musculoskeletal injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000701 name: Intraoperative neurological injury def: "A finding of damage to the nervous system during a surgical procedure OR Damage to any part of the nervous system during a surgical procedure." [NCI:CTCAE, NCIT:C78384] xref: UMLS:C1699210 xref: NCI:CTCAE:10065830 xref: NCIT:C78384 property_value: ESCORT_rule "CCTO:000701 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative neurological injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000701 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative neurological injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000701(time_t t0) = EVENT_STATE(CCTO:000701, t0)" xsd:string ! schema ''Intraoperative neurological injury''(time_t t0) = EVENT_STATE(''Intraoperative neurological injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000702 name: Intraoperative ocular injury def: "Damage to the eye during a surgical procedure OR A finding of damage to the eye during a surgical procedure." [NCIT:C78385, NCI:CTCAE] xref: UMLS:C1699740 xref: NCI:CTCAE:10065841 xref: NCIT:C78385 property_value: ESCORT_rule "CCTO:000702 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative ocular injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000702 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative ocular injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000702(time_t t0) = EVENT_STATE(CCTO:000702, t0)" xsd:string ! schema ''Intraoperative ocular injury''(time_t t0) = EVENT_STATE(''Intraoperative ocular injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000703 name: Intraoperative renal injury def: "Damage to the kidney during a surgical procedure OR A finding of damage to the kidney during a surgical procedure." [NCIT:C78386, NCI:CTCAE] xref: UMLS:C1699743 xref: NCI:CTCAE:10065845 xref: NCIT:C78386 property_value: ESCORT_rule "CCTO:000703 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative renal injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000703 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative renal injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000703(time_t t0) = EVENT_STATE(CCTO:000703, t0)" xsd:string ! schema ''Intraoperative renal injury''(time_t t0) = EVENT_STATE(''Intraoperative renal injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000704 name: Intraoperative reproductive tract injury def: "A finding of damage to the reproductive organs during a surgical procedure OR Damage to the reproductive organs during a surgical procedure." [NCI:CTCAE, NCIT:C78387] synonym: "Intraoperative reproductive system injury" EXACT [NCIT:C78387] xref: UMLS:C1699739 xref: NCI:CTCAE:10065840 xref: NCIT:C78387 property_value: ESCORT_rule "CCTO:000704 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative reproductive tract injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000704 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative reproductive tract injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000704(time_t t0) = EVENT_STATE(CCTO:000704, t0)" xsd:string ! schema ''Intraoperative reproductive tract injury''(time_t t0) = EVENT_STATE(''Intraoperative reproductive tract injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000705 name: Intraoperative respiratory injury def: "Damage to the respiratory system during a surgical procedure OR A finding of damage to the respiratory system during a surgical procedure." [NCIT:C78388, NCI:CTCAE] xref: UMLS:C1699737 xref: NCI:CTCAE:10065832 xref: NCIT:C78388 property_value: ESCORT_rule "CCTO:000705 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative respiratory injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000705 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative respiratory injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000705(time_t t0) = EVENT_STATE(CCTO:000705, t0)" xsd:string ! schema ''Intraoperative respiratory injury''(time_t t0) = EVENT_STATE(''Intraoperative respiratory injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000706 name: Intraoperative skin injury def: "Damage to the skin during a surgical procedure OR A finding of damage to the skin during a surgical procedure." [NCIT:C78389, NCI:CTCAE] xref: UMLS:C1558746 xref: NCI:CTCAE:10065846 xref: NCIT:C78389 property_value: ESCORT_rule "CCTO:000706 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative skin injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000706 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative skin injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000706(time_t t0) = EVENT_STATE(CCTO:000706, t0)" xsd:string ! schema ''Intraoperative skin injury''(time_t t0) = EVENT_STATE(''Intraoperative skin injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000707 name: Intraoperative splenic injury def: "Damage to the spleen during a surgical procedure OR A finding of damage to the spleen during a surgical procedure." [NCIT:C78390, NCI:CTCAE] xref: UMLS:C1698099 xref: NCI:CTCAE:10065847 xref: NCIT:C78390 property_value: ESCORT_rule "CCTO:000707 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative splenic injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000707 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative splenic injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000707(time_t t0) = EVENT_STATE(CCTO:000707, t0)" xsd:string ! schema ''Intraoperative splenic injury''(time_t t0) = EVENT_STATE(''Intraoperative splenic injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000708 name: Intraoperative urinary injury def: "A finding of damage to the urinary system during a surgical procedure OR Damage to any part of the urinary system during a surgical procedure." [NCI:CTCAE, NCIT:C78391] synonym: "Intraoperative urinary system injury" EXACT [NCIT:C78391] xref: UMLS:C1698677 xref: NCI:CTCAE:10065828 xref: NCIT:C78391 property_value: ESCORT_rule "CCTO:000708 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative urinary injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000708 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative urinary injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000708(time_t t0) = EVENT_STATE(CCTO:000708, t0)" xsd:string ! schema ''Intraoperative urinary injury''(time_t t0) = EVENT_STATE(''Intraoperative urinary injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000709 name: Intraoperative venous injury def: "A finding of damage to a vein during a surgical procedure OR Damage to a vein during a surgical procedure." [NCI:CTCAE, NCIT:C78392] xref: UMLS:C1698100 xref: NCI:CTCAE:10065848 xref: NCIT:C78392 property_value: ESCORT_rule "CCTO:000709 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intraoperative venous injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000709 implies CCTO:001120" xsd:string ! ESCORT_rule ''Intraoperative venous injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000709(time_t t0) = EVENT_STATE(CCTO:000709, t0)" xsd:string ! schema ''Intraoperative venous injury''(time_t t0) = EVENT_STATE(''Intraoperative venous injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000710 name: Kidney anastomotic leak def: "A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures) OR Leakage of urine due to breakdown of a kidney anastomosis." [NCI:CTCAE, NCIT:C78406] synonym: "Kidney anastomotic leakage" EXACT [NCIT:C78406] xref: UMLS:C1699736 xref: NCI:CTCAE:10065803 xref: NCIT:C78406 property_value: ESCORT_rule "CCTO:000710 implies CCTO:000049" xsd:string ! ESCORT_rule ''Kidney anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000710 implies CCTO:001120" xsd:string ! ESCORT_rule ''Kidney anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000710(time_t t0) = EVENT_STATE(CCTO:000710, t0)" xsd:string ! schema ''Kidney anastomotic leak''(time_t t0) = EVENT_STATE(''Kidney anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000711 name: Large intestinal anastomotic leak def: "Leakage due to breakdown of a large intestinal anastomosis OR A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine." [NCIT:C78408, NCI:CTCAE] synonym: "Large intestinal anastomotic leakage" EXACT [NCIT:C78408] xref: UMLS:C1699327 xref: NCI:CTCAE:10065891 xref: NCIT:C78408 property_value: ESCORT_rule "CCTO:000711 implies CCTO:000049" xsd:string ! ESCORT_rule ''Large intestinal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000711 implies CCTO:001120" xsd:string ! ESCORT_rule ''Large intestinal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000711(time_t t0) = EVENT_STATE(CCTO:000711, t0)" xsd:string ! schema ''Large intestinal anastomotic leak''(time_t t0) = EVENT_STATE(''Large intestinal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000712 name: Pancreatic anastomotic leak def: "Leakage due to breakdown of a pancreatic anastomosis OR A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78518, NCI:CTCAE] synonym: "Pancreatic anastomotic leakage" EXACT [NCIT:C78518] xref: UMLS:C0341498 xref: NCI:CTCAE:10050457 xref: NCIT:C78518 property_value: ESCORT_rule "CCTO:000712 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatic anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000712 implies CCTO:001120" xsd:string ! ESCORT_rule ''Pancreatic anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000712(time_t t0) = EVENT_STATE(CCTO:000712, t0)" xsd:string ! schema ''Pancreatic anastomotic leak''(time_t t0) = EVENT_STATE(''Pancreatic anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000713 name: Pharyngeal anastomotic leak def: "A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a pharyngeal anastomosis." [NCI:CTCAE, NCIT:C78550] synonym: "Pharyngeal anastomotic leakage" EXACT [NCIT:C78550] xref: UMLS:C1696702 xref: NCI:CTCAE:10065705 xref: NCIT:C78550 property_value: ESCORT_rule "CCTO:000713 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngeal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000713 implies CCTO:001120" xsd:string ! ESCORT_rule ''Pharyngeal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000713(time_t t0) = EVENT_STATE(CCTO:000713, t0)" xsd:string ! schema ''Pharyngeal anastomotic leak''(time_t t0) = EVENT_STATE(''Pharyngeal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000714 name: Postoperative hemorrhage def: "A finding of bleeding occurring after a surgical procedure OR Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related." [NCI:CTCAE, NCIT:C34938] synonym: "Postoperative bleeding" EXACT [NCIT:C34938] xref: UMLS:C0032788 xref: NCI:CTCAE:10055322 xref: NCIT:C34938 property_value: ESCORT_rule "CCTO:000714 implies CCTO:000049" xsd:string ! ESCORT_rule ''Postoperative hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000714 implies CCTO:001120" xsd:string ! ESCORT_rule ''Postoperative hemorrhage'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000714(time_t t0) = EVENT_STATE(CCTO:000714, t0)" xsd:string ! schema ''Postoperative hemorrhage''(time_t t0) = EVENT_STATE(''Postoperative hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000715 name: Postoperative thoracic procedure complication def: "Any disorder occurring postoperatively as a consequence of a thoracic procedure OR A finding of a previously undocumented problem that occurs after a thoracic procedure." [NCIT:C78567, NCI:CTCAE] synonym: "Thoracic procedure postoperative complication" EXACT [NCIT:C78567] xref: UMLS:C1112276 xref: NCI:CTCAE:10056745 xref: NCIT:C78567 property_value: ESCORT_rule "CCTO:000715 implies CCTO:000049" xsd:string ! ESCORT_rule ''Postoperative thoracic procedure complication'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000715 implies CCTO:001120" xsd:string ! ESCORT_rule ''Postoperative thoracic procedure complication'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000715(time_t t0) = EVENT_STATE(CCTO:000715, t0)" xsd:string ! schema ''Postoperative thoracic procedure complication''(time_t t0) = EVENT_STATE(''Postoperative thoracic procedure complication'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000716 name: Prolapse of intestinal stoma def: "An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface OR A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface." [NCIT:C78570, NCI:CTCAE] synonym: "Enterostomy prolapse" EXACT [NCIT:C78570] synonym: "Intestinal stoma prolapse" EXACT [NCIT:C78570] xref: UMLS:C1699141 xref: NCI:CTCAE:10065745 xref: NCIT:C78570 property_value: ESCORT_rule "CCTO:000716 implies CCTO:000049" xsd:string ! ESCORT_rule ''Prolapse of intestinal stoma'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000716 implies CCTO:001120" xsd:string ! ESCORT_rule ''Prolapse of intestinal stoma'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000716(time_t t0) = EVENT_STATE(CCTO:000716, t0)" xsd:string ! schema ''Prolapse of intestinal stoma''(time_t t0) = EVENT_STATE(''Prolapse of intestinal stoma'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000717 name: Prolapse of urostomy def: "Displacement of the urostomy OR A finding of displacement of the urostomy." [NCIT:C78571, NCI:CTCAE] synonym: "Urostomy prolapse" EXACT [NCIT:C78571] xref: UMLS:C1698096 xref: NCI:CTCAE:10065822 xref: NCIT:C78571 property_value: ESCORT_rule "CCTO:000717 implies CCTO:000049" xsd:string ! ESCORT_rule ''Prolapse of urostomy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000717 implies CCTO:001120" xsd:string ! ESCORT_rule ''Prolapse of urostomy'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000717(time_t t0) = EVENT_STATE(CCTO:000717, t0)" xsd:string ! schema ''Prolapse of urostomy''(time_t t0) = EVENT_STATE(''Prolapse of urostomy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000718 name: Radiation recall reaction (dermatologic) def: "A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent OR Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent." [NCI:CTCAE, NCIT:C78580] synonym: "Radiation recall dermatitis" EXACT [NCIT:C78580] synonym: "Radiation recall reaction (dermatologic)" EXACT [NCIT:C78580] synonym: "Radiation-recall dermatitis" EXACT [NCIT:C78580] xref: UMLS:C1720798 xref: NCI:CTCAE:10037767 xref: NCIT:C78580 property_value: ESCORT_rule "CCTO:000718 implies CCTO:000049" xsd:string ! ESCORT_rule ''Radiation recall reaction (dermatologic)'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000718 implies CCTO:001120" xsd:string ! ESCORT_rule ''Radiation recall reaction (dermatologic)'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000718(time_t t0) = EVENT_STATE(CCTO:000718, t0)" xsd:string ! schema ''Radiation recall reaction (dermatologic)''(time_t t0) = EVENT_STATE(''Radiation recall reaction (dermatologic)'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000719 name: Rectal anastomotic leak def: "Leakage due to breakdown of a rectal anastomosis OR A finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78583, NCI:CTCAE] synonym: "Rectal anastomotic leakage" EXACT [NCIT:C78583] xref: UMLS:C1698511 xref: NCI:CTCAE:10065894 xref: NCIT:C78583 property_value: ESCORT_rule "CCTO:000719 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rectal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000719 implies CCTO:001120" xsd:string ! ESCORT_rule ''Rectal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000719(time_t t0) = EVENT_STATE(CCTO:000719, t0)" xsd:string ! schema ''Rectal anastomotic leak''(time_t t0) = EVENT_STATE(''Rectal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000720 name: Seroma def: "A collection of serum in the body OR A finding of tumor-like collection of serum in the tissues." [NCIT:C50739, NCI:CTCAE] synonym: "Seroma adverse event" EXACT [NCIT:C58401] xref: UMLS:C0262627 xref: UMLS:C1963233 xref: NCI:CTCAE:10040102 xref: NCIT:C50739 xref: NCIT:C58401 property_value: ESCORT_rule "CCTO:000720 implies CCTO:000049" xsd:string ! ESCORT_rule ''Seroma'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000720 implies CCTO:001120" xsd:string ! ESCORT_rule ''Seroma'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000720(time_t t0) = EVENT_STATE(CCTO:000720, t0)" xsd:string ! schema ''Seroma''(time_t t0) = EVENT_STATE(''Seroma'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000721 name: Small intestinal anastomotic leak def: "A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel OR Leakage due to breakdown of a small intestinal anastomosis." [NCI:CTCAE, NCIT:C78612] synonym: "Small intestinal anastomotic leakage" EXACT [NCIT:C78612] xref: UMLS:C1698195 xref: NCI:CTCAE:10065892 xref: NCIT:C78612 property_value: ESCORT_rule "CCTO:000721 implies CCTO:000049" xsd:string ! ESCORT_rule ''Small intestinal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000721 implies CCTO:001120" xsd:string ! ESCORT_rule ''Small intestinal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000721(time_t t0) = EVENT_STATE(CCTO:000721, t0)" xsd:string ! schema ''Small intestinal anastomotic leak''(time_t t0) = EVENT_STATE(''Small intestinal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000722 name: Spermatic cord anastomotic leak def: "Leakage due to breakdown of a spermatic cord anastomosis OR A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78622, NCI:CTCAE] synonym: "Spermatic cord anastomotic leakage" EXACT [NCIT:C78622] xref: UMLS:C1699328 xref: NCI:CTCAE:10065897 xref: NCIT:C78622 property_value: ESCORT_rule "CCTO:000722 implies CCTO:000049" xsd:string ! ESCORT_rule ''Spermatic cord anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000722 implies CCTO:001120" xsd:string ! ESCORT_rule ''Spermatic cord anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000722(time_t t0) = EVENT_STATE(CCTO:000722, t0)" xsd:string ! schema ''Spermatic cord anastomotic leak''(time_t t0) = EVENT_STATE(''Spermatic cord anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000723 name: Spinal fracture def: "Traumatic or pathological injury to the spine in which the continuity of a vertebral bone is broken. Symptoms include back pain and difficulty bending and twisting OR A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken." [NCIT:C80516, NCI:CTCAE] synonym: "Vertebral fracture" EXACT [NCIT:C80516] xref: UMLS:C0080179 xref: NCI:CTCAE:10041569 xref: NCIT:C80516 property_value: ESCORT_rule "CCTO:000723 implies CCTO:000049" xsd:string ! ESCORT_rule ''Spinal fracture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000723 implies CCTO:001120" xsd:string ! ESCORT_rule ''Spinal fracture'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000723(time_t t0) = EVENT_STATE(CCTO:000723, t0)" xsd:string ! schema ''Spinal fracture''(time_t t0) = EVENT_STATE(''Spinal fracture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000724 name: Stenosis of gastrointestinal stoma def: "Narrowing of the lumen of a gastrointestinal stoma OR A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body)." [NCIT:C78628, NCI:CTCAE] synonym: "Gastrointestinal stoma stenosis" EXACT [NCIT:C78628] xref: UMLS:C1699177 xref: NCI:CTCAE:10065898 xref: NCIT:C78628 property_value: ESCORT_rule "CCTO:000724 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stenosis of gastrointestinal stoma'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000724 implies CCTO:001120" xsd:string ! ESCORT_rule ''Stenosis of gastrointestinal stoma'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000724(time_t t0) = EVENT_STATE(CCTO:000724, t0)" xsd:string ! schema ''Stenosis of gastrointestinal stoma''(time_t t0) = EVENT_STATE(''Stenosis of gastrointestinal stoma'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000725 name: Stomal ulcer def: "An ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure." [NCIT:C79766, NCI:CTCAE] synonym: "Marginal ulcer" EXACT [NCIT:C79766] xref: UMLS:C0024799 xref: NCI:CTCAE:10042127 xref: NCIT:C79766 property_value: ESCORT_rule "CCTO:000725 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stomal ulcer'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000725 implies CCTO:001120" xsd:string ! ESCORT_rule ''Stomal ulcer'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000725(time_t t0) = EVENT_STATE(CCTO:000725, t0)" xsd:string ! schema ''Stomal ulcer''(time_t t0) = EVENT_STATE(''Stomal ulcer'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000726 name: Tracheal hemorrhage def: "A finding of bleeding from the trachea OR Bleeding originating from the trachea." [NCI:CTCAE, NCIT:C78642] xref: UMLS:C0340220 xref: NCI:CTCAE:10062548 xref: NCIT:C78642 property_value: ESCORT_rule "CCTO:000726 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000726 implies CCTO:001120" xsd:string ! ESCORT_rule ''Tracheal hemorrhage'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000726(time_t t0) = EVENT_STATE(CCTO:000726, t0)" xsd:string ! schema ''Tracheal hemorrhage''(time_t t0) = EVENT_STATE(''Tracheal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000727 name: Tracheal obstruction def: "A finding of blockage of the lumen of the trachea OR Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors." [NCI:CTCAE, NCIT:C78645] xref: UMLS:C0340221 xref: NCI:CTCAE:10044291 xref: NCIT:C78645 property_value: ESCORT_rule "CCTO:000727 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000727 implies CCTO:001120" xsd:string ! ESCORT_rule ''Tracheal obstruction'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000727(time_t t0) = EVENT_STATE(CCTO:000727, t0)" xsd:string ! schema ''Tracheal obstruction''(time_t t0) = EVENT_STATE(''Tracheal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000728 name: Tracheostomy site bleeding def: "A finding of blood leakage from the tracheostomy site OR Bleeding from the tracheostomy site." [NCI:CTCAE, NCIT:C78648] xref: UMLS:C1699657 xref: NCI:CTCAE:10065749 xref: NCIT:C78648 property_value: ESCORT_rule "CCTO:000728 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheostomy site bleeding'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000728 implies CCTO:001120" xsd:string ! ESCORT_rule ''Tracheostomy site bleeding'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000728(time_t t0) = EVENT_STATE(CCTO:000728, t0)" xsd:string ! schema ''Tracheostomy site bleeding''(time_t t0) = EVENT_STATE(''Tracheostomy site bleeding'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000729 name: Ureteric anastomotic leak def: "A finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a ureteral anastomosis." [NCI:CTCAE, NCIT:C78662] synonym: "Ureteral anastomotic leak" EXACT [NCIT:C78662] synonym: "Ureteric anastomotic leakage" EXACT [NCIT:C78662] xref: UMLS:C1698675 xref: NCI:CTCAE:10065814 xref: NCIT:C78662 property_value: ESCORT_rule "CCTO:000729 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ureteric anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000729 implies CCTO:001120" xsd:string ! ESCORT_rule ''Ureteric anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000729(time_t t0) = EVENT_STATE(CCTO:000729, t0)" xsd:string ! schema ''Ureteric anastomotic leak''(time_t t0) = EVENT_STATE(''Ureteric anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000730 name: Urethral anastomotic leak def: "A finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a urethral anastomosis." [NCI:CTCAE, NCIT:C78667] synonym: "Urethral anastomotic leakage" EXACT [NCIT:C78667] xref: UMLS:C1699207 xref: NCI:CTCAE:10065815 xref: NCIT:C78667 property_value: ESCORT_rule "CCTO:000730 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urethral anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000730 implies CCTO:001120" xsd:string ! ESCORT_rule ''Urethral anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000730(time_t t0) = EVENT_STATE(CCTO:000730, t0)" xsd:string ! schema ''Urethral anastomotic leak''(time_t t0) = EVENT_STATE(''Urethral anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000731 name: Urostomy leak def: "A finding of leakage of contents from a urostomy OR Leakage of contents from a urostomy." [NCI:CTCAE, NCIT:C78679] synonym: "Urostomy leakage" EXACT [NCIT:C78679] xref: UMLS:C1698193 xref: NCI:CTCAE:10065882 xref: NCIT:C78679 property_value: ESCORT_rule "CCTO:000731 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urostomy leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000731 implies CCTO:001120" xsd:string ! ESCORT_rule ''Urostomy leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000731(time_t t0) = EVENT_STATE(CCTO:000731, t0)" xsd:string ! schema ''Urostomy leak''(time_t t0) = EVENT_STATE(''Urostomy leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000732 name: Urostomy obstruction def: "A finding of blockage of the urostomy OR Blockage of the urostomy." [NCI:CTCAE, NCIT:C78680] xref: UMLS:C1697984 xref: NCI:CTCAE:10065883 xref: NCIT:C78680 property_value: ESCORT_rule "CCTO:000732 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urostomy obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000732 implies CCTO:001120" xsd:string ! ESCORT_rule ''Urostomy obstruction'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000732(time_t t0) = EVENT_STATE(CCTO:000732, t0)" xsd:string ! schema ''Urostomy obstruction''(time_t t0) = EVENT_STATE(''Urostomy obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000733 name: Urostomy site bleeding def: "A finding of bleeding from the urostomy site OR Hemorrhage from the urostomy site." [NCI:CTCAE, NCIT:C78682] xref: UMLS:C1698628 xref: NCI:CTCAE:10065748 xref: NCIT:C78682 property_value: ESCORT_rule "CCTO:000733 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urostomy site bleeding'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000733 implies CCTO:001120" xsd:string ! ESCORT_rule ''Urostomy site bleeding'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000733(time_t t0) = EVENT_STATE(CCTO:000733, t0)" xsd:string ! schema ''Urostomy site bleeding''(time_t t0) = EVENT_STATE(''Urostomy site bleeding'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000734 name: Urostomy stenosis def: "Narrowing of the opening of a urostomy OR A finding of narrowing of the opening of a urostomy." [NCIT:C78683, NCI:CTCAE] xref: UMLS:C1698769 xref: NCI:CTCAE:10065885 xref: NCIT:C78683 property_value: ESCORT_rule "CCTO:000734 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urostomy stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000734 implies CCTO:001120" xsd:string ! ESCORT_rule ''Urostomy stenosis'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000734(time_t t0) = EVENT_STATE(CCTO:000734, t0)" xsd:string ! schema ''Urostomy stenosis''(time_t t0) = EVENT_STATE(''Urostomy stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000735 name: Uterine anastomotic leak def: "Leakage due to breakdown of a uterine anastomosis OR A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78684, NCI:CTCAE] synonym: "Uterine anastomotic leakage" EXACT [NCIT:C78684] xref: UMLS:C1699812 xref: NCI:CTCAE:10065886 xref: NCIT:C78684 property_value: ESCORT_rule "CCTO:000735 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uterine anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000735 implies CCTO:001120" xsd:string ! ESCORT_rule ''Uterine anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000735(time_t t0) = EVENT_STATE(CCTO:000735, t0)" xsd:string ! schema ''Uterine anastomotic leak''(time_t t0) = EVENT_STATE(''Uterine anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000736 name: Uterine perforation def: "A rupture in the uterus due to traumatic or pathologic processes OR A disorder characterized by a rupture in the uterine wall." [NCIT:C50793, NCI:CTCAE] synonym: "Perforation of uterus" EXACT [NCIT:C50793] synonym: "Uterus perforation" EXACT [NCIT:C50793] synonym: "Uterus wall perforation" EXACT [NCIT:C50793] xref: UMLS:C0042139 xref: UMLS:C1963265 xref: NCI:CTCAE:10046810 xref: NCIT:C50793 property_value: ESCORT_rule "CCTO:000736 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uterine perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000736 implies CCTO:001120" xsd:string ! ESCORT_rule ''Uterine perforation'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000736(time_t t0) = EVENT_STATE(CCTO:000736, t0)" xsd:string ! schema ''Uterine perforation''(time_t t0) = EVENT_STATE(''Uterine perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000737 name: Vaginal anastomotic leak def: "Leakage due to breakdown of a vaginal anastomosis OR A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78698, NCI:CTCAE] synonym: "Vaginal anastomotic leakage" EXACT [NCIT:C78698] xref: UMLS:C1698194 xref: NCI:CTCAE:10065887 xref: NCIT:C78698 property_value: ESCORT_rule "CCTO:000737 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000737 implies CCTO:001120" xsd:string ! ESCORT_rule ''Vaginal anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000737(time_t t0) = EVENT_STATE(CCTO:000737, t0)" xsd:string ! schema ''Vaginal anastomotic leak''(time_t t0) = EVENT_STATE(''Vaginal anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000738 name: Vas deferens anastomotic leak def: "Leakage due to breakdown of a vas deferens anastomosis OR A finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures)." [NCIT:C78704, NCI:CTCAE] synonym: "Vas deferens anastomotic leakage" EXACT [NCIT:C78704] xref: UMLS:C1699326 xref: NCI:CTCAE:10065888 xref: NCIT:C78704 property_value: ESCORT_rule "CCTO:000738 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vas deferens anastomotic leak'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000738 implies CCTO:001120" xsd:string ! ESCORT_rule ''Vas deferens anastomotic leak'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000738(time_t t0) = EVENT_STATE(CCTO:000738, t0)" xsd:string ! schema ''Vas deferens anastomotic leak''(time_t t0) = EVENT_STATE(''Vas deferens anastomotic leak'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000739 name: Vascular access complication def: "Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis OR A finding of a previously undocumented problem related to the vascular access site." [NCIT:C78709, NCI:CTCAE] xref: UMLS:C0920165 xref: NCI:CTCAE:10062169 xref: NCIT:C78709 property_value: ESCORT_rule "CCTO:000739 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vascular access complication'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000739 implies CCTO:001120" xsd:string ! ESCORT_rule ''Vascular access complication'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000739(time_t t0) = EVENT_STATE(CCTO:000739, t0)" xsd:string ! schema ''Vascular access complication''(time_t t0) = EVENT_STATE(''Vascular access complication'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000740 name: Venous injury def: "A finding of damage to a vein OR Damage to a vein from traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78711] xref: UMLS:C0340770 xref: NCI:CTCAE:10047228 xref: NCIT:C78711 property_value: ESCORT_rule "CCTO:000740 implies CCTO:000049" xsd:string ! ESCORT_rule ''Venous injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000740 implies CCTO:001120" xsd:string ! ESCORT_rule ''Venous injury'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000740(time_t t0) = EVENT_STATE(CCTO:000740, t0)" xsd:string ! schema ''Venous injury''(time_t t0) = EVENT_STATE(''Venous injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000741 name: Wound complication def: "A medical condition that develops at the site of an existing wound. Examples include swelling, draining, bleeding, formation of hematoma, infection, and necrosis OR A finding of development of a new problem at the site of an existing wound." [NCIT:C78719, NCI:CTCAE] synonym: "Wound healing complication" EXACT [NCIT:C78719] synonym: "Wound healing disorder" EXACT [NCIT:C78719] xref: UMLS:C1096106 xref: NCI:CTCAE:10053692 xref: NCIT:C78719 property_value: ESCORT_rule "CCTO:000741 implies CCTO:000049" xsd:string ! ESCORT_rule ''Wound complication'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000741 implies CCTO:001120" xsd:string ! ESCORT_rule ''Wound complication'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000741(time_t t0) = EVENT_STATE(CCTO:000741, t0)" xsd:string ! schema ''Wound complication''(time_t t0) = EVENT_STATE(''Wound complication'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000742 name: Wound dehiscence def: "A finding of separation of the approximated margins of a surgical wound OR Splitting of the sutured margins of a surgical wound. Risk factors include diabetes mellitus, obesity, and advanced age." [NCI:CTCAE, NCIT:C50863] synonym: "Dehiscence wound" EXACT [NCIT:C50863] synonym: "Wound disruption" EXACT [NCIT:C50863] xref: UMLS:C0259768 xref: NCI:CTCAE:10048031 xref: NCIT:C50863 property_value: ESCORT_rule "CCTO:000742 implies CCTO:000049" xsd:string ! ESCORT_rule ''Wound dehiscence'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000742 implies CCTO:001120" xsd:string ! ESCORT_rule ''Wound dehiscence'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000742(time_t t0) = EVENT_STATE(CCTO:000742, t0)" xsd:string ! schema ''Wound dehiscence''(time_t t0) = EVENT_STATE(''Wound dehiscence'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000743 name: Wrist fracture def: "Traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. Symptoms include wrist pain, swelling, and deformity of wrist OR A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken." [NCIT:C80517, NCI:CTCAE] xref: UMLS:C0435630 xref: NCI:CTCAE:10048049 xref: NCIT:C80517 property_value: ESCORT_rule "CCTO:000743 implies CCTO:000049" xsd:string ! ESCORT_rule ''Wrist fracture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000743 implies CCTO:001120" xsd:string ! ESCORT_rule ''Wrist fracture'' implies ''Injury, poisoning and procedural complications'' property_value: schema "CCTO:000743(time_t t0) = EVENT_STATE(CCTO:000743, t0)" xsd:string ! schema ''Wrist fracture''(time_t t0) = EVENT_STATE(''Wrist fracture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001120 ! Injury, poisoning and procedural complications relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000744 name: Activated partial thromboplastin time prolonged def: "An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment OR An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment." [NCIT:C27028, NCI:CTCAE] synonym: "Prolonged activated partial thromboplastin time" EXACT [NCIT:C27028] synonym: "Prolonged partial thromboplastin time" EXACT [NCIT:C27028] xref: UMLS:C0240671 xref: NCI:CTCAE:10000636 xref: NCIT:C27028 property_value: ESCORT_rule "CCTO:000744 implies CCTO:000049" xsd:string ! ESCORT_rule ''Activated partial thromboplastin time prolonged'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000744 implies CCTO:000051" xsd:string ! ESCORT_rule ''Activated partial thromboplastin time prolonged'' implies ''Investigation'' property_value: schema "CCTO:000744(time_t t0) = EVENT_STATE(CCTO:000744, t0)" xsd:string ! schema ''Activated partial thromboplastin time prolonged''(time_t t0) = EVENT_STATE(''Activated partial thromboplastin time prolonged'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000745 name: Alanine aminotransferase increased def: "A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen OR An increase in the level of alanine aminotransferase in the blood." [NCI:CTCAE, NCIT:C26948] xref: UMLS:C0151905 xref: NCI:CTCAE:10001551 xref: NCIT:C26948 property_value: ESCORT_rule "CCTO:000745 implies CCTO:000049" xsd:string ! ESCORT_rule ''Alanine aminotransferase increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000745 implies CCTO:000051" xsd:string ! ESCORT_rule ''Alanine aminotransferase increased'' implies ''Investigation'' property_value: schema "CCTO:000745(time_t t0) = EVENT_STATE(CCTO:000745, t0)" xsd:string ! schema ''Alanine aminotransferase increased''(time_t t0) = EVENT_STATE(''Alanine aminotransferase increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000746 name: Alkaline phosphatase increased def: "A laboratory test result which indicates an increased level of alkaline phosphatase in a biological specimen OR A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen." [NCIT:C35607, NCI:CTCAE] synonym: "Blood alkaline phosphatase increased" EXACT [NCIT:C35607] xref: UMLS:C0852911 xref: UMLS:C0151849 xref: NCI:CTCAE:10001675 xref: NCIT:C35607 property_value: ESCORT_rule "CCTO:000746 implies CCTO:000049" xsd:string ! ESCORT_rule ''Alkaline phosphatase increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000746 implies CCTO:000051" xsd:string ! ESCORT_rule ''Alkaline phosphatase increased'' implies ''Investigation'' property_value: schema "CCTO:000746(time_t t0) = EVENT_STATE(CCTO:000746, t0)" xsd:string ! schema ''Alkaline phosphatase increased''(time_t t0) = EVENT_STATE(''Alkaline phosphatase increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000747 name: Aspartate aminotransferase increased def: "An increase in the level of aspartate aminotransferase in the blood OR A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen." [NCIT:C26947, NCI:CTCAE] xref: UMLS:C0151904 xref: NCI:CTCAE:10003481 xref: NCIT:C26947 property_value: ESCORT_rule "CCTO:000747 implies CCTO:000049" xsd:string ! ESCORT_rule ''Aspartate aminotransferase increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000747 implies CCTO:000051" xsd:string ! ESCORT_rule ''Aspartate aminotransferase increased'' implies ''Investigation'' property_value: schema "CCTO:000747(time_t t0) = EVENT_STATE(CCTO:000747, t0)" xsd:string ! schema ''Aspartate aminotransferase increased''(time_t t0) = EVENT_STATE(''Aspartate aminotransferase increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000748 name: Blood antidiuretic hormone abnormal def: "A finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen OR A laboratory test result which indicates abnormal levels of antidiuretic hormone in the blood." [NCI:CTCAE, NCIT:C78214] synonym: "Abnormal blood antidiuretic hormone" EXACT [NCIT:C78214] xref: UMLS:C0853592 xref: NCI:CTCAE:10005332 xref: NCIT:C78214 property_value: ESCORT_rule "CCTO:000748 implies CCTO:000049" xsd:string ! ESCORT_rule ''Blood antidiuretic hormone abnormal'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000748 implies CCTO:000051" xsd:string ! ESCORT_rule ''Blood antidiuretic hormone abnormal'' implies ''Investigation'' property_value: schema "CCTO:000748(time_t t0) = EVENT_STATE(CCTO:000748, t0)" xsd:string ! schema ''Blood antidiuretic hormone abnormal''(time_t t0) = EVENT_STATE(''Blood antidiuretic hormone abnormal'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000749 name: Blood bilirubin increased def: "Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice OR A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice." [NCIT:C27088, NCI:CTCAE] synonym: "Hyperbilirubinemia" EXACT [NCIT:C27088] xref: UMLS:C0020433 xref: UMLS:C0311468 xref: NCI:CTCAE:10005364 xref: NCIT:C27088 property_value: ESCORT_rule "CCTO:000749 implies CCTO:000049" xsd:string ! ESCORT_rule ''Blood bilirubin increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000749 implies CCTO:000051" xsd:string ! ESCORT_rule ''Blood bilirubin increased'' implies ''Investigation'' property_value: schema "CCTO:000749(time_t t0) = EVENT_STATE(CCTO:000749, t0)" xsd:string ! schema ''Blood bilirubin increased''(time_t t0) = EVENT_STATE(''Blood bilirubin increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000750 name: Blood corticotrophin decreased def: "A laboratory test result which indicates decreased levels of corticotrophin in the blood OR A finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen." [NCIT:C78215, NCI:CTCAE] xref: UMLS:C0853122 xref: NCI:CTCAE:10005452 xref: NCIT:C78215 property_value: ESCORT_rule "CCTO:000750 implies CCTO:000049" xsd:string ! ESCORT_rule ''Blood corticotrophin decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000750 implies CCTO:000051" xsd:string ! ESCORT_rule ''Blood corticotrophin decreased'' implies ''Investigation'' property_value: schema "CCTO:000750(time_t t0) = EVENT_STATE(CCTO:000750, t0)" xsd:string ! schema ''Blood corticotrophin decreased''(time_t t0) = EVENT_STATE(''Blood corticotrophin decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000751 name: Blood gonadotrophin abnormal def: "A laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood OR A finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen." [NCIT:C78216, NCI:CTCAE] synonym: "Abnormal blood gonadotrophin" EXACT [NCIT:C78216] xref: UMLS:C0853603 xref: NCI:CTCAE:10005561 xref: NCIT:C78216 property_value: ESCORT_rule "CCTO:000751 implies CCTO:000049" xsd:string ! ESCORT_rule ''Blood gonadotrophin abnormal'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000751 implies CCTO:000051" xsd:string ! ESCORT_rule ''Blood gonadotrophin abnormal'' implies ''Investigation'' property_value: schema "CCTO:000751(time_t t0) = EVENT_STATE(CCTO:000751, t0)" xsd:string ! schema ''Blood gonadotrophin abnormal''(time_t t0) = EVENT_STATE(''Blood gonadotrophin abnormal'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000752 name: Blood prolactin abnormal def: "A finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen OR A laboratory test result which indicates abnormal levels of prolactin hormone in the blood." [NCI:CTCAE, NCIT:C78217] synonym: "Abnormal blood prolactin" EXACT [NCIT:C78217] xref: UMLS:C0853620 xref: NCI:CTCAE:10005778 xref: NCIT:C78217 property_value: ESCORT_rule "CCTO:000752 implies CCTO:000049" xsd:string ! ESCORT_rule ''Blood prolactin abnormal'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000752 implies CCTO:000051" xsd:string ! ESCORT_rule ''Blood prolactin abnormal'' implies ''Investigation'' property_value: schema "CCTO:000752(time_t t0) = EVENT_STATE(CCTO:000752, t0)" xsd:string ! schema ''Blood prolactin abnormal''(time_t t0) = EVENT_STATE(''Blood prolactin abnormal'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000753 name: Carbon monoxide diffusing capacity decreased def: "A finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide OR A lung function test result in which the lung capacity to absorb carbon monoxide is decreased." [NCI:CTCAE, NCIT:C78229] synonym: "Decreased carbon monoxide diffusing capacity" EXACT [NCIT:C78229] xref: UMLS:C1697788 xref: NCI:CTCAE:10065906 xref: NCIT:C78229 property_value: ESCORT_rule "CCTO:000753 implies CCTO:000049" xsd:string ! ESCORT_rule ''Carbon monoxide diffusing capacity decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000753 implies CCTO:000051" xsd:string ! ESCORT_rule ''Carbon monoxide diffusing capacity decreased'' implies ''Investigation'' property_value: schema "CCTO:000753(time_t t0) = EVENT_STATE(CCTO:000753, t0)" xsd:string ! schema ''Carbon monoxide diffusing capacity decreased''(time_t t0) = EVENT_STATE(''Carbon monoxide diffusing capacity decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000754 name: Cardiac troponin I increased def: "A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen OR A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen." [NCIT:C78230, NCI:CTCAE] synonym: "Blood Cardiac Troponin I Increased" EXACT [NCIT:C78230] xref: UMLS:C0852692 xref: NCI:CTCAE:10007612 xref: NCIT:C78230 property_value: ESCORT_rule "CCTO:000754 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cardiac troponin I increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000754 implies CCTO:000051" xsd:string ! ESCORT_rule ''Cardiac troponin I increased'' implies ''Investigation'' property_value: schema "CCTO:000754(time_t t0) = EVENT_STATE(CCTO:000754, t0)" xsd:string ! schema ''Cardiac troponin I increased''(time_t t0) = EVENT_STATE(''Cardiac troponin I increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000755 name: Cardiac troponin T increased def: "A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen OR A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen." [NCI:CTCAE, NCIT:C78231] synonym: "Blood Cardiac Troponin T Increased" EXACT [NCIT:C78231] xref: UMLS:C0852680 xref: NCI:CTCAE:10007613 xref: NCIT:C78231 property_value: ESCORT_rule "CCTO:000755 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cardiac troponin T increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000755 implies CCTO:000051" xsd:string ! ESCORT_rule ''Cardiac troponin T increased'' implies ''Investigation'' property_value: schema "CCTO:000755(time_t t0) = EVENT_STATE(CCTO:000755, t0)" xsd:string ! schema ''Cardiac troponin T increased''(time_t t0) = EVENT_STATE(''Cardiac troponin T increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000756 name: CD4 lymphocytes decreased def: "A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen OR A laboratory test result which indicates decreased levels of CD4 lymphocytes in a biospecimen." [NCI:CTCAE, NCIT:C78233] xref: UMLS:C0853142 xref: NCI:CTCAE:10007839 xref: NCIT:C78233 property_value: ESCORT_rule "CCTO:000756 implies CCTO:000049" xsd:string ! ESCORT_rule ''CD4 lymphocytes decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000756 implies CCTO:000051" xsd:string ! ESCORT_rule ''CD4 lymphocytes decreased'' implies ''Investigation'' property_value: schema "CCTO:000756(time_t t0) = EVENT_STATE(CCTO:000756, t0)" xsd:string ! schema ''CD4 lymphocytes decreased''(time_t t0) = EVENT_STATE(''CD4 lymphocytes decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000757 name: Cholesterol high def: "A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen OR A laboratory test result indicating an increased amount of cholesterol in the blood." [NCI:CTCAE, NCIT:C37967] synonym: "High cholesterol" EXACT [NCIT:C37967] synonym: "Hypercholesterolemia" EXACT [NCIT:C37967] xref: UMLS:C1522133 xref: UMLS:C0020443 xref: NCI:CTCAE:10008661 xref: NCIT:C37967 property_value: ESCORT_rule "CCTO:000757 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cholesterol high'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000757 implies CCTO:000051" xsd:string ! ESCORT_rule ''Cholesterol high'' implies ''Investigation'' property_value: schema "CCTO:000757(time_t t0) = EVENT_STATE(CCTO:000757, t0)" xsd:string ! schema ''Cholesterol high''(time_t t0) = EVENT_STATE(''Cholesterol high'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000758 name: CPK increased def: "A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen OR A laboratory test result which indicates increased levels of creatine phosphokinase in a biological specimen." [NCI:CTCAE, NCIT:C78247] synonym: "Creatine phosphokinase increased" EXACT [NCIT:C78247] xref: UMLS:C0151576 xref: NCI:CTCAE:10011268 xref: NCIT:C78247 property_value: ESCORT_rule "CCTO:000758 implies CCTO:000049" xsd:string ! ESCORT_rule ''CPK increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000758 implies CCTO:000051" xsd:string ! ESCORT_rule ''CPK increased'' implies ''Investigation'' property_value: schema "CCTO:000758(time_t t0) = EVENT_STATE(CCTO:000758, t0)" xsd:string ! schema ''CPK increased''(time_t t0) = EVENT_STATE(''CPK increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000759 name: Creatinine increased def: "A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen OR A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen." [NCI:CTCAE, NCIT:C78249] synonym: "Elevated creatinine" EXACT [NCIT:C78249] synonym: "Increased creatinine" EXACT [NCIT:C78249] xref: UMLS:C0151578 xref: NCI:CTCAE:10011368 xref: NCIT:C78249 property_value: ESCORT_rule "CCTO:000759 implies CCTO:000049" xsd:string ! ESCORT_rule ''Creatinine increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000759 implies CCTO:000051" xsd:string ! ESCORT_rule ''Creatinine increased'' implies ''Investigation'' property_value: schema "CCTO:000759(time_t t0) = EVENT_STATE(CCTO:000759, t0)" xsd:string ! schema ''Creatinine increased''(time_t t0) = EVENT_STATE(''Creatinine increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000760 name: Ejection fraction decreased def: "A finding indicating a decrease in the volume of blood ejected during ventricular heart contraction OR The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction." [NCIT:C83492, NCI:CTCAE] xref: UMLS:C0743400 xref: NCI:CTCAE:10050528 xref: NCIT:C83492 property_value: ESCORT_rule "CCTO:000760 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ejection fraction decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000760 implies CCTO:000051" xsd:string ! ESCORT_rule ''Ejection fraction decreased'' implies ''Investigation'' property_value: schema "CCTO:000760(time_t t0) = EVENT_STATE(CCTO:000760, t0)" xsd:string ! schema ''Ejection fraction decreased''(time_t t0) = EVENT_STATE(''Ejection fraction decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000761 name: Electrocardiogram QT corrected interval prolonged def: "A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval OR An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC)" [NCI:CTCAE, NCIT:C83817] synonym: "Corrected Prolonged QT Interval by ECG Finding" EXACT [NCIT:C83817] synonym: "Corrected Prolonged QT Interval by EKG Finding" EXACT [NCIT:C83817] synonym: "Corrected Prolonged QT Interval" EXACT [NCIT:C83817] synonym: "QTc Prolongation" EXACT [NCIT:C83817] xref: UMLS:C0855333 xref: NCI:CTCAE:10014383 xref: NCIT:C83817 property_value: ESCORT_rule "CCTO:000761 implies CCTO:000049" xsd:string ! ESCORT_rule ''Electrocardiogram QT corrected interval prolonged'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000761 implies CCTO:000051" xsd:string ! ESCORT_rule ''Electrocardiogram QT corrected interval prolonged'' implies ''Investigation'' property_value: schema "CCTO:000761(time_t t0) = EVENT_STATE(CCTO:000761, t0)" xsd:string ! schema ''Electrocardiogram QT corrected interval prolonged''(time_t t0) = EVENT_STATE(''Electrocardiogram QT corrected interval prolonged'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000762 name: Fibrinogen decreased def: "A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen OR A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen." [NCI:CTCAE, NCIT:C78300] xref: UMLS:C1295715 xref: NCI:CTCAE:10016596 xref: NCIT:C78300 property_value: ESCORT_rule "CCTO:000762 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fibrinogen decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000762 implies CCTO:000051" xsd:string ! ESCORT_rule ''Fibrinogen decreased'' implies ''Investigation'' property_value: schema "CCTO:000762(time_t t0) = EVENT_STATE(CCTO:000762, t0)" xsd:string ! schema ''Fibrinogen decreased''(time_t t0) = EVENT_STATE(''Fibrinogen decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000763 name: Forced expiratory volume decreased def: "A decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds OR A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds." [NCIT:C50524, NCI:CTCAE] synonym: "Decreased Forced Expiratory Volume (FEV)" EXACT [NCIT:C50524] synonym: "Decreased forced expiratory volume" EXACT [NCIT:C50524] synonym: "FEV (Forced Expiratory Volume), Decreased" EXACT [NCIT:C50524] synonym: "FEV Decreased" EXACT [NCIT:C50524] synonym: "Forced Expiratory Volume (FEV), Decreased" EXACT [NCIT:C50524] synonym: "Forced expiratory volume, decreased" EXACT [NCIT:C50524] synonym: "Volume (FEV), Decreased Forced Expiratory" EXACT [NCIT:C50524] xref: UMLS:C0520837 xref: NCI:CTCAE:10016987 xref: NCIT:C50524 property_value: ESCORT_rule "CCTO:000763 implies CCTO:000049" xsd:string ! ESCORT_rule ''Forced expiratory volume decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000763 implies CCTO:000051" xsd:string ! ESCORT_rule ''Forced expiratory volume decreased'' implies ''Investigation'' property_value: schema "CCTO:000763(time_t t0) = EVENT_STATE(CCTO:000763, t0)" xsd:string ! schema ''Forced expiratory volume decreased''(time_t t0) = EVENT_STATE(''Forced expiratory volume decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000764 name: GGT increased def: "Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water OR A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water." [NCIT:C26943, NCI:CTCAE] synonym: "Gamma-glutamyltransferase increased" EXACT [NCIT:C26943] xref: UMLS:C0151662 xref: NCI:CTCAE:10056910 xref: NCIT:C26943 property_value: ESCORT_rule "CCTO:000764 implies CCTO:000049" xsd:string ! ESCORT_rule ''GGT increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000764 implies CCTO:000051" xsd:string ! ESCORT_rule ''GGT increased'' implies ''Investigation'' property_value: schema "CCTO:000764(time_t t0) = EVENT_STATE(CCTO:000764, t0)" xsd:string ! schema ''GGT increased''(time_t t0) = EVENT_STATE(''GGT increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000765 name: Growth hormone abnormal def: "A laboratory test result which indicates abnormal levels of growth hormone in a biologic specimen OR A finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen." [NCIT:C78327, NCI:CTCAE] synonym: "Abnormal growth hormone" EXACT [NCIT:C78327] xref: UMLS:C0860787 xref: NCI:CTCAE:10018748 xref: NCIT:C78327 property_value: ESCORT_rule "CCTO:000765 implies CCTO:000049" xsd:string ! ESCORT_rule ''Growth hormone abnormal'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000765 implies CCTO:000051" xsd:string ! ESCORT_rule ''Growth hormone abnormal'' implies ''Investigation'' property_value: schema "CCTO:000765(time_t t0) = EVENT_STATE(CCTO:000765, t0)" xsd:string ! schema ''Growth hormone abnormal''(time_t t0) = EVENT_STATE(''Growth hormone abnormal'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000766 name: Haptoglobin decreased def: "A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen OR A laboratory test result which indicates decreased levels of haptoglobin in a biological specimen." [NCI:CTCAE, NCIT:C78330] xref: UMLS:C0236062 xref: NCI:CTCAE:10019150 xref: NCIT:C78330 property_value: ESCORT_rule "CCTO:000766 implies CCTO:000049" xsd:string ! ESCORT_rule ''Haptoglobin decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000766 implies CCTO:000051" xsd:string ! ESCORT_rule ''Haptoglobin decreased'' implies ''Investigation'' property_value: schema "CCTO:000766(time_t t0) = EVENT_STATE(CCTO:000766, t0)" xsd:string ! schema ''Haptoglobin decreased''(time_t t0) = EVENT_STATE(''Haptoglobin decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000767 name: Hemoglobin increased def: "A laboratory test result which indicates increased levels of hemoglobin in a biological specimen OR A finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen." [NCIT:C78333, NCI:CTCAE] xref: UMLS:C0549448 xref: NCI:CTCAE:10055599 xref: NCIT:C78333 property_value: ESCORT_rule "CCTO:000767 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hemoglobin increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000767 implies CCTO:000051" xsd:string ! ESCORT_rule ''Hemoglobin increased'' implies ''Investigation'' property_value: schema "CCTO:000767(time_t t0) = EVENT_STATE(CCTO:000767, t0)" xsd:string ! schema ''Hemoglobin increased''(time_t t0) = EVENT_STATE(''Hemoglobin increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000768 name: INR increased def: "A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood OR A laboratory test result demonstrating an increased ratio of the patient's prothrombin time to a control sample." [NCI:CTCAE, NCIT:C78366] synonym: "Elevated prothrombin time international normalized ratio" EXACT [NCIT:C78366] synonym: "International normalized ratio increased" EXACT [NCIT:C78366] synonym: "Supratherapeutic international normalized ratio" EXACT [NCIT:C78366] xref: UMLS:C0853225 xref: NCI:CTCAE:10022402 xref: NCIT:C78366 property_value: ESCORT_rule "CCTO:000768 implies CCTO:000049" xsd:string ! ESCORT_rule ''INR increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000768 implies CCTO:000051" xsd:string ! ESCORT_rule ''INR increased'' implies ''Investigation'' property_value: schema "CCTO:000768(time_t t0) = EVENT_STATE(CCTO:000768, t0)" xsd:string ! schema ''INR increased''(time_t t0) = EVENT_STATE(''INR increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000769 name: Lipase increased def: "A laboratory test result which indicates increased levels of lipase in a biologic specimen OR A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen." [NCIT:C78435, NCI:CTCAE] synonym: "Elevated lipase" EXACT [NCIT:C78435] synonym: "Hyperlipasemia" EXACT [NCIT:C78435] xref: UMLS:C1963823 xref: UMLS:C0549475 xref: NCI:CTCAE:10024574 xref: NCIT:C78435 property_value: ESCORT_rule "CCTO:000769 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lipase increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000769 implies CCTO:000051" xsd:string ! ESCORT_rule ''Lipase increased'' implies ''Investigation'' property_value: schema "CCTO:000769(time_t t0) = EVENT_STATE(CCTO:000769, t0)" xsd:string ! schema ''Lipase increased''(time_t t0) = EVENT_STATE(''Lipase increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000770 name: Lymphocyte count decreased def: "A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen OR An abnormally small number of lymphocytes in the circulating blood." [NCI:CTCAE, NCIT:C26823] synonym: "Lymphocytopenia" EXACT [NCIT:C26823] synonym: "Lymphopenia" EXACT [NCIT:C26823] synonym: "lymphocytic leukopenia" EXACT [NCIT:C26823] xref: UMLS:C0853986 xref: UMLS:C0024312 xref: NCI:CTCAE:10025256 xref: NCIT:C26823 property_value: ESCORT_rule "CCTO:000770 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lymphocyte count decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000770 implies CCTO:000051" xsd:string ! ESCORT_rule ''Lymphocyte count decreased'' implies ''Investigation'' property_value: schema "CCTO:000770(time_t t0) = EVENT_STATE(CCTO:000770, t0)" xsd:string ! schema ''Lymphocyte count decreased''(time_t t0) = EVENT_STATE(''Lymphocyte count decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000771 name: Lymphocyte count increased def: "A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow OR A laboratory test result indicating an abnormal increase in the number of lymphocytes in the peripheral blood, effusions, or bone marrow." [NCI:CTCAE, NCIT:C34791] synonym: "Lymphocytosis" EXACT [NCIT:C34791] xref: UMLS:C0853698 xref: UMLS:C0024282 xref: NCI:CTCAE:10025258 xref: NCIT:C34791 property_value: ESCORT_rule "CCTO:000771 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lymphocyte count increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000771 implies CCTO:000051" xsd:string ! ESCORT_rule ''Lymphocyte count increased'' implies ''Investigation'' property_value: schema "CCTO:000771(time_t t0) = EVENT_STATE(CCTO:000771, t0)" xsd:string ! schema ''Lymphocyte count increased''(time_t t0) = EVENT_STATE(''Lymphocyte count increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000772 name: Neutrophil count decreased def: "A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen OR A decrease in the number of neutrophils in the peripheral blood." [NCI:CTCAE, NCIT:C80520] synonym: "Granulocytopenia" EXACT [NCIT:C80520] synonym: "Neutropenia" EXACT [NCIT:C80520] xref: UMLS:C0001824 xref: UMLS:C0027947 xref: UMLS:C0853697 xref: UMLS:C0023530 xref: NCI:CTCAE:10029366 xref: NCIT:C80520 property_value: ESCORT_rule "CCTO:000772 implies CCTO:000049" xsd:string ! ESCORT_rule ''Neutrophil count decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000772 implies CCTO:000051" xsd:string ! ESCORT_rule ''Neutrophil count decreased'' implies ''Investigation'' property_value: schema "CCTO:000772(time_t t0) = EVENT_STATE(CCTO:000772, t0)" xsd:string ! schema ''Neutrophil count decreased''(time_t t0) = EVENT_STATE(''Neutrophil count decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000773 name: Pancreatic enzymes decreased def: "A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen OR A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen." [NCI:CTCAE, NCIT:C78520] xref: UMLS:C0549370 xref: NCI:CTCAE:10062646 xref: NCIT:C78520 property_value: ESCORT_rule "CCTO:000773 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pancreatic enzymes decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000773 implies CCTO:000051" xsd:string ! ESCORT_rule ''Pancreatic enzymes decreased'' implies ''Investigation'' property_value: schema "CCTO:000773(time_t t0) = EVENT_STATE(CCTO:000773, t0)" xsd:string ! schema ''Pancreatic enzymes decreased''(time_t t0) = EVENT_STATE(''Pancreatic enzymes decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000774 name: Platelet count decreased def: "A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen OR A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood." [NCI:CTCAE, NCIT:C3408] synonym: "Thrombocytopenia" EXACT [NCIT:C3408] synonym: "Thrombocytopenic disorder" EXACT [NCIT:C3408] xref: UMLS:C0040034 xref: UMLS:C0392386 xref: NCI:CTCAE:10035528 xref: NCIT:C3408 property_value: ESCORT_rule "CCTO:000774 implies CCTO:000049" xsd:string ! ESCORT_rule ''Platelet count decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000774 implies CCTO:000051" xsd:string ! ESCORT_rule ''Platelet count decreased'' implies ''Investigation'' property_value: schema "CCTO:000774(time_t t0) = EVENT_STATE(CCTO:000774, t0)" xsd:string ! schema ''Platelet count decreased''(time_t t0) = EVENT_STATE(''Platelet count decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000775 name: Serum amylase increased def: "A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen OR A laboratory test indicating increased levels of amylase in the serum." [NCI:CTCAE, NCIT:C78608] xref: UMLS:C0476327 xref: NCI:CTCAE:10040139 xref: NCIT:C78608 property_value: ESCORT_rule "CCTO:000775 implies CCTO:000049" xsd:string ! ESCORT_rule ''Serum amylase increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000775 implies CCTO:000051" xsd:string ! ESCORT_rule ''Serum amylase increased'' implies ''Investigation'' property_value: schema "CCTO:000775(time_t t0) = EVENT_STATE(CCTO:000775, t0)" xsd:string ! schema ''Serum amylase increased''(time_t t0) = EVENT_STATE(''Serum amylase increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000776 name: Urine output decreased def: "A finding based on test results that indicate urine production is less relative to previous output OR A finding indicating that the urine production is less than 500 milliliters during a 24 hour period." [NCI:CTCAE, NCIT:C80522] xref: UMLS:C0028961 xref: NCI:CTCAE:10059895 xref: NCIT:C80522 property_value: ESCORT_rule "CCTO:000776 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urine output decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000776 implies CCTO:000051" xsd:string ! ESCORT_rule ''Urine output decreased'' implies ''Investigation'' property_value: schema "CCTO:000776(time_t t0) = EVENT_STATE(CCTO:000776, t0)" xsd:string ! schema ''Urine output decreased''(time_t t0) = EVENT_STATE(''Urine output decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000777 name: Vital capacity abnormal def: "A pulmonary function test result indicating an abnormal vital capacity as compared to the predicted value OR A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value." [NCIT:C78715, NCI:CTCAE] synonym: "Abnormal vital capacity" EXACT [NCIT:C78715] xref: UMLS:C0853735 xref: NCI:CTCAE:10047580 xref: NCIT:C78715 property_value: ESCORT_rule "CCTO:000777 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vital capacity abnormal'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000777 implies CCTO:000051" xsd:string ! ESCORT_rule ''Vital capacity abnormal'' implies ''Investigation'' property_value: schema "CCTO:000777(time_t t0) = EVENT_STATE(CCTO:000777, t0)" xsd:string ! schema ''Vital capacity abnormal''(time_t t0) = EVENT_STATE(''Vital capacity abnormal'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000778 name: Weight gain def: "A question about whether an individual is or was bothered by weight gain OR An increase in total body weight OR A finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve." [NCIT:C125673, NCIT:C62754, NCI:CTCAE] synonym: "BWGAIN" EXACT [NCIT:C62754] synonym: "Body weight gain" EXACT [NCIT:C62754] synonym: "Bothered by Weight Gain" EXACT [NCIT:C125673] synonym: "Weight gain adverse event" EXACT [NCIT:C55338] synonym: "Weight increase" EXACT [NCIT:C62754] xref: UMLS:C0043094 xref: UMLS:C2911647 xref: NCI:CTCAE:10047896 xref: NCIT:C125673 xref: NCIT:C55338 xref: NCIT:C62754 property_value: ESCORT_rule "CCTO:000778 implies CCTO:000049" xsd:string ! ESCORT_rule ''Weight gain'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000778 implies CCTO:000051" xsd:string ! ESCORT_rule ''Weight gain'' implies ''Investigation'' property_value: schema "CCTO:000778(time_t t0) = EVENT_STATE(CCTO:000778, t0)" xsd:string ! schema ''Weight gain''(time_t t0) = EVENT_STATE(''Weight gain'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000779 name: White blood cell decreased def: "A laboratory test result indicating a decreased number of white blood cells in the peripheral blood OR A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen." [NCIT:C26816, NCI:CTCAE] synonym: "Leukocytopenia" EXACT [NCIT:C26816] synonym: "Leukopenia" EXACT [NCIT:C26816] xref: UMLS:C0023530 xref: UMLS:C0750394 xref: NCI:CTCAE:10049182 xref: NCIT:C26816 property_value: ESCORT_rule "CCTO:000779 implies CCTO:000049" xsd:string ! ESCORT_rule ''White blood cell decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000779 implies CCTO:000051" xsd:string ! ESCORT_rule ''White blood cell decreased'' implies ''Investigation'' property_value: schema "CCTO:000779(time_t t0) = EVENT_STATE(CCTO:000779, t0)" xsd:string ! schema ''White blood cell decreased''(time_t t0) = EVENT_STATE(''White blood cell decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:000051 ! Investigations relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000780 name: Acidosis def: "An abnormally high acidity of the blood and other body tissues. Acidosis can be either respiratory or metabolic OR A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues OR Increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock OR An abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues." [NCIT:C83504, NCI:CTCAE, NCIT:C28228, NCIT:C37906] synonym: "Metabolic acidosis" EXACT [NCIT:C28228] xref: UMLS:C0220981 xref: UMLS:C0001122 xref: NCI:CTCAE:10000486 xref: NCIT:C28228 xref: NCIT:C37906 xref: NCIT:C83504 property_value: ESCORT_rule "CCTO:000780 implies CCTO:000049" xsd:string ! ESCORT_rule ''Acidosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000780 implies CCTO:001121" xsd:string ! ESCORT_rule ''Acidosis'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000780(time_t t0) = EVENT_STATE(CCTO:000780, t0)" xsd:string ! schema ''Acidosis''(time_t t0) = EVENT_STATE(''Acidosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000781 name: Alcohol intolerance def: "A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches OR Increased sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches." [NCI:CTCAE, NCIT:C78167] xref: UMLS:C0151474 xref: NCI:CTCAE:10001598 xref: NCIT:C78167 property_value: ESCORT_rule "CCTO:000781 implies CCTO:000049" xsd:string ! ESCORT_rule ''Alcohol intolerance'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000781 implies CCTO:001121" xsd:string ! ESCORT_rule ''Alcohol intolerance'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000781(time_t t0) = EVENT_STATE(CCTO:000781, t0)" xsd:string ! schema ''Alcohol intolerance''(time_t t0) = EVENT_STATE(''Alcohol intolerance'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000782 name: Alkalosis def: "An abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues OR A disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues." [NCIT:C37909, NCI:CTCAE] xref: UMLS:C0002063 xref: NCI:CTCAE:10001680 xref: NCIT:C37909 property_value: ESCORT_rule "CCTO:000782 implies CCTO:000049" xsd:string ! ESCORT_rule ''Alkalosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000782 implies CCTO:001121" xsd:string ! ESCORT_rule ''Alkalosis'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000782(time_t t0) = EVENT_STATE(CCTO:000782, t0)" xsd:string ! schema ''Alkalosis''(time_t t0) = EVENT_STATE(''Alkalosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000783 name: Anorexia def: "Loss of appetite OR A disorder characterized by a loss of appetite." [NCIT:C2875, NCI:CTCAE] synonym: "Anorexia adverse event" EXACT [NCIT:C57118] xref: UMLS:C0003123 xref: UMLS:C1963063 xref: NCI:CTCAE:10002646 xref: NCIT:C2875 xref: NCIT:C57118 property_value: ESCORT_rule "CCTO:000783 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anorexia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000783 implies CCTO:001121" xsd:string ! ESCORT_rule ''Anorexia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000783(time_t t0) = EVENT_STATE(CCTO:000783, t0)" xsd:string ! schema ''Anorexia''(time_t t0) = EVENT_STATE(''Anorexia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000784 name: Dehydration def: "A condition resulting from the excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis OR Any procedure designed to remove the water from a substance or sample OR A disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis." [NCIT:C26740, NCIT:C126369, NCI:CTCAE] synonym: "Dehydrated" EXACT [NCIT:C26740] synonym: "Dehydration adverse event" EXACT [NCIT:C57787] synonym: "Dehydration procedure" EXACT [NCIT:C126369] synonym: "Dehydration technique" EXACT [NCIT:C126369] xref: UMLS:C0011175 xref: UMLS:C1963090 xref: NCI:CTCAE:10012174 xref: NCIT:C126369 xref: NCIT:C26740 xref: NCIT:C57787 property_value: ESCORT_rule "CCTO:000784 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dehydration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000784 implies CCTO:001121" xsd:string ! ESCORT_rule ''Dehydration'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000784(time_t t0) = EVENT_STATE(CCTO:000784, t0)" xsd:string ! schema ''Dehydration''(time_t t0) = EVENT_STATE(''Dehydration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000785 name: Glucose intolerance def: "The inability to regulate blood glucose levels resulting in hyperglycemia OR A disorder characterized by an inability to properly metabolize glucose." [NCIT:C34646, NCI:CTCAE] xref: UMLS:C0271650 xref: NCI:CTCAE:10052426 xref: NCIT:C34646 property_value: ESCORT_rule "CCTO:000785 implies CCTO:000049" xsd:string ! ESCORT_rule ''Glucose intolerance'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000785 implies CCTO:001121" xsd:string ! ESCORT_rule ''Glucose intolerance'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000785(time_t t0) = EVENT_STATE(CCTO:000785, t0)" xsd:string ! schema ''Glucose intolerance''(time_t t0) = EVENT_STATE(''Glucose intolerance'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000786 name: Hypercalcemia def: "Abnormally high concentration of calcium in the peripheral blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood." [NCIT:C3112, NCI:CTCAE] xref: UMLS:C0020437 xref: NCI:CTCAE:10020587 xref: NCIT:C3112 property_value: ESCORT_rule "CCTO:000786 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypercalcemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000786 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypercalcemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000786(time_t t0) = EVENT_STATE(CCTO:000786, t0)" xsd:string ! schema ''Hypercalcemia''(time_t t0) = EVENT_STATE(''Hypercalcemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000787 name: Hyperglycemia def: "A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance OR Abnormally high level of glucose in the blood." [NCI:CTCAE, NCIT:C26797] synonym: "Blood glucose, high" EXACT [NCIT:C26797] synonym: "Elevated blood glucose" EXACT [NCIT:C26797] synonym: "Glucose, high blood" EXACT [NCIT:C26797] synonym: "High blood glucose" EXACT [NCIT:C26797] synonym: "high blood sugar" EXACT [NCIT:C26797] xref: UMLS:C0020456 xref: UMLS:C0595877 xref: NCI:CTCAE:10020639 xref: NCIT:C26797 property_value: ESCORT_rule "CCTO:000787 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperglycemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000787 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hyperglycemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000787(time_t t0) = EVENT_STATE(CCTO:000787, t0)" xsd:string ! schema ''Hyperglycemia''(time_t t0) = EVENT_STATE(''Hyperglycemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000788 name: Hyperkalemia def: "A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs OR Higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs." [NCI:CTCAE, NCIT:C37968] xref: UMLS:C0020461 xref: NCI:CTCAE:10020647 xref: NCIT:C37968 property_value: ESCORT_rule "CCTO:000788 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperkalemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000788 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hyperkalemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000788(time_t t0) = EVENT_STATE(CCTO:000788, t0)" xsd:string ! schema ''Hyperkalemia''(time_t t0) = EVENT_STATE(''Hyperkalemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000789 name: Hypermagnesemia def: "Higher than normal levels of magnesium in the circulating blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood." [NCIT:C37969, NCI:CTCAE] xref: UMLS:C0151714 xref: NCI:CTCAE:10020670 xref: NCIT:C37969 property_value: ESCORT_rule "CCTO:000789 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypermagnesemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000789 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypermagnesemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000789(time_t t0) = EVENT_STATE(CCTO:000789, t0)" xsd:string ! schema ''Hypermagnesemia''(time_t t0) = EVENT_STATE(''Hypermagnesemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000790 name: Hypernatremia def: "Higher than normal levels of sodium in the circulating blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood." [NCIT:C37970, NCI:CTCAE] xref: UMLS:C0020488 xref: NCI:CTCAE:10020680 xref: NCIT:C37970 property_value: ESCORT_rule "CCTO:000790 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypernatremia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000790 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypernatremia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000790(time_t t0) = EVENT_STATE(CCTO:000790, t0)" xsd:string ! schema ''Hypernatremia''(time_t t0) = EVENT_STATE(''Hypernatremia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000791 name: Hypertriglyceridemia def: "A laboratory test result indicating elevated triglyceride concentration in the blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood." [NCIT:C37971, NCI:CTCAE] synonym: "High triglycerides" EXACT [NCIT:C37971] xref: UMLS:C0020557 xref: UMLS:C1522137 xref: NCI:CTCAE:10020870 xref: NCIT:C37971 property_value: ESCORT_rule "CCTO:000791 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypertriglyceridemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000791 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypertriglyceridemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000791(time_t t0) = EVENT_STATE(CCTO:000791, t0)" xsd:string ! schema ''Hypertriglyceridemia''(time_t t0) = EVENT_STATE(''Hypertriglyceridemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000792 name: Hyperuricemia def: "A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid OR Elevated blood concentrations of uric acid." [NCI:CTCAE, NCIT:C3961] xref: UMLS:C0740394 xref: NCI:CTCAE:10020907 xref: NCIT:C3961 property_value: ESCORT_rule "CCTO:000792 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperuricemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000792 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hyperuricemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000792(time_t t0) = EVENT_STATE(CCTO:000792, t0)" xsd:string ! schema ''Hyperuricemia''(time_t t0) = EVENT_STATE(''Hyperuricemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000793 name: Hypoalbuminemia def: "A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood OR Concentration of serum albumin below normal limits for the age related normal range." [NCI:CTCAE, NCIT:C37972] xref: UMLS:C0239981 xref: UMLS:C3665623 xref: NCI:CTCAE:10020943 xref: NCIT:C37972 property_value: ESCORT_rule "CCTO:000793 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypoalbuminemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000793 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypoalbuminemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000793(time_t t0) = EVENT_STATE(CCTO:000793, t0)" xsd:string ! schema ''Hypoalbuminemia''(time_t t0) = EVENT_STATE(''Hypoalbuminemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000794 name: Hypocalcemia def: "Lower than normal levels of calcium in the circulating blood OR A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood." [NCIT:C37973, NCI:CTCAE] xref: UMLS:C0020598 xref: NCI:CTCAE:10020949 xref: NCIT:C37973 property_value: ESCORT_rule "CCTO:000794 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypocalcemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000794 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypocalcemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000794(time_t t0) = EVENT_STATE(CCTO:000794, t0)" xsd:string ! schema ''Hypocalcemia''(time_t t0) = EVENT_STATE(''Hypocalcemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000795 name: Hypoglycemia def: "A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood OR Abnormally low level of glucose in the blood." [NCI:CTCAE, NCIT:C3126] synonym: "Blood glucose, low" EXACT [NCIT:C3126] synonym: "Glucose, low blood" EXACT [NCIT:C3126] synonym: "Low blood glucose" EXACT [NCIT:C3126] xref: UMLS:C0020615 xref: NCI:CTCAE:10021005 xref: NCIT:C3126 property_value: ESCORT_rule "CCTO:000795 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypoglycemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000795 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypoglycemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000795(time_t t0) = EVENT_STATE(CCTO:000795, t0)" xsd:string ! schema ''Hypoglycemia''(time_t t0) = EVENT_STATE(''Hypoglycemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000796 name: Hypokalemia def: "A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood OR Lower than normal levels of potassium in the circulating blood." [NCI:CTCAE, NCIT:C37974] xref: UMLS:C0020621 xref: NCI:CTCAE:10021018 xref: NCIT:C37974 property_value: ESCORT_rule "CCTO:000796 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypokalemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000796 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypokalemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000796(time_t t0) = EVENT_STATE(CCTO:000796, t0)" xsd:string ! schema ''Hypokalemia''(time_t t0) = EVENT_STATE(''Hypokalemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000797 name: Hypomagnesemia def: "A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood OR Lower than normal levels of magnesium in the circulating blood." [NCI:CTCAE, NCIT:C37975] xref: UMLS:C0151723 xref: NCI:CTCAE:10021028 xref: NCIT:C37975 property_value: ESCORT_rule "CCTO:000797 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypomagnesemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000797 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypomagnesemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000797(time_t t0) = EVENT_STATE(CCTO:000797, t0)" xsd:string ! schema ''Hypomagnesemia''(time_t t0) = EVENT_STATE(''Hypomagnesemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000798 name: Hyponatremia def: "A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood OR Lower than normal levels of sodium in the circulating blood." [NCI:CTCAE, NCIT:C37976] xref: UMLS:C0020625 xref: NCI:CTCAE:10021038 xref: NCIT:C37976 property_value: ESCORT_rule "CCTO:000798 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyponatremia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000798 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hyponatremia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000798(time_t t0) = EVENT_STATE(CCTO:000798, t0)" xsd:string ! schema ''Hyponatremia''(time_t t0) = EVENT_STATE(''Hyponatremia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000799 name: Hypophosphatemia def: "A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood OR Lower than normal levels of phosphates in the circulating blood." [NCI:CTCAE, NCIT:C37977] xref: UMLS:C0085682 xref: NCI:CTCAE:10021059 xref: NCIT:C37977 property_value: ESCORT_rule "CCTO:000799 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypophosphatemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000799 implies CCTO:001121" xsd:string ! ESCORT_rule ''Hypophosphatemia'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000799(time_t t0) = EVENT_STATE(CCTO:000799, t0)" xsd:string ! schema ''Hypophosphatemia''(time_t t0) = EVENT_STATE(''Hypophosphatemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000800 name: Iron overload def: "An adverse event resulting in accumulation of iron in the tissues OR Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death OR A disorder characterized by accumulation of iron in the tissues." [NCIT:C55993, NCIT:C78393, NCI:CTCAE] synonym: "Iron overload adverse event" EXACT [NCIT:C55993] xref: UMLS:C0282193 xref: UMLS:C1963148 xref: NCI:CTCAE:10065973 xref: NCIT:C55993 xref: NCIT:C78393 property_value: ESCORT_rule "CCTO:000800 implies CCTO:000049" xsd:string ! ESCORT_rule ''Iron overload'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000800 implies CCTO:001121" xsd:string ! ESCORT_rule ''Iron overload'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000800(time_t t0) = EVENT_STATE(CCTO:000800, t0)" xsd:string ! schema ''Iron overload''(time_t t0) = EVENT_STATE(''Iron overload'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000801 name: Obesity def: "Having a high amount of body fat (body mass index [BMI] of 30 or more) OR A disorder characterized by having a high amount of body fat." [NCIT:C3283, NCI:CTCAE] synonym: "Obesity adverse event" EXACT [NCIT:C55334] xref: UMLS:C0028754 xref: UMLS:C1963185 xref: NCI:CTCAE:10029883 xref: NCIT:C3283 xref: NCIT:C55334 property_value: ESCORT_rule "CCTO:000801 implies CCTO:000049" xsd:string ! ESCORT_rule ''Obesity'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000801 implies CCTO:001121" xsd:string ! ESCORT_rule ''Obesity'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000801(time_t t0) = EVENT_STATE(CCTO:000801, t0)" xsd:string ! schema ''Obesity''(time_t t0) = EVENT_STATE(''Obesity'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000802 name: Tumor lysis syndrome def: "A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells OR A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death." [NCI:CTCAE, NCIT:C3425] synonym: "Tumor lysis syndrome adverse event" EXACT [NCIT:C56638] xref: UMLS:C0041364 xref: UMLS:C1963254 xref: NCI:CTCAE:10045152 xref: NCIT:C3425 xref: NCIT:C56638 property_value: ESCORT_rule "CCTO:000802 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tumor lysis syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000802 implies CCTO:001121" xsd:string ! ESCORT_rule ''Tumor lysis syndrome'' implies ''Metabolism and nutrition disorders'' property_value: schema "CCTO:000802(time_t t0) = EVENT_STATE(CCTO:000802, t0)" xsd:string ! schema ''Tumor lysis syndrome''(time_t t0) = EVENT_STATE(''Tumor lysis syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001121 ! Metabolism and nutrition disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000803 name: Abdominal soft tissue necrosis def: "A necrotic process occurring in the soft tissues of the abdominal wall OR A disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall." [NCIT:C78165, NCI:CTCAE] synonym: "Abdominal soft tissue necrotic lesion" EXACT [NCIT:C78165] xref: UMLS:C1699695 xref: NCI:CTCAE:10065775 xref: NCIT:C78165 property_value: ESCORT_rule "CCTO:000803 implies CCTO:000049" xsd:string ! ESCORT_rule ''Abdominal soft tissue necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000803 implies CCTO:001109" xsd:string ! ESCORT_rule ''Abdominal soft tissue necrosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000803(time_t t0) = EVENT_STATE(CCTO:000803, t0)" xsd:string ! schema ''Abdominal soft tissue necrosis''(time_t t0) = EVENT_STATE(''Abdominal soft tissue necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000804 name: Arthralgia def: "A disorder characterized by a sensation of marked discomfort in a joint OR Pain in a joint." [NCI:CTCAE, NCIT:C50464] synonym: "Arthrodynia" EXACT [NCIT:C50464] synonym: "Joint pain" EXACT [NCIT:C50464] synonym: "Pain, joint" EXACT [NCIT:C50464] xref: UMLS:C0003862 xref: UMLS:C1963066 xref: NCI:CTCAE:10003239 xref: NCIT:C50464 property_value: ESCORT_rule "CCTO:000804 implies CCTO:000049" xsd:string ! ESCORT_rule ''Arthralgia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000804 implies CCTO:001109" xsd:string ! ESCORT_rule ''Arthralgia'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000804(time_t t0) = EVENT_STATE(CCTO:000804, t0)" xsd:string ! schema ''Arthralgia''(time_t t0) = EVENT_STATE(''Arthralgia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000805 name: Arthritis def: "A disorder characterized by inflammation involving a joint OR An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain." [NCI:CTCAE, NCIT:C2883] xref: UMLS:C0003864 xref: NCI:CTCAE:10003246 xref: NCIT:C2883 property_value: ESCORT_rule "CCTO:000805 implies CCTO:000049" xsd:string ! ESCORT_rule ''Arthritis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000805 implies CCTO:001109" xsd:string ! ESCORT_rule ''Arthritis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000805(time_t t0) = EVENT_STATE(CCTO:000805, t0)" xsd:string ! schema ''Arthritis''(time_t t0) = EVENT_STATE(''Arthritis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000806 name: Avascular necrosis def: "Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure OR Tissue death resulting from an interruption to the blood supply OR A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure." [NCIT:C34841, NCIT:C118385, NCI:CTCAE] synonym: "AVN" EXACT [NCIT:C118385] synonym: "Avascular Necrosis of Bone" EXACT [NCIT:C34841] xref: UMLS:C0027543 xref: NCI:CTCAE:10066480 xref: NCIT:C118385 xref: NCIT:C34841 property_value: ESCORT_rule "CCTO:000806 implies CCTO:000049" xsd:string ! ESCORT_rule ''Avascular necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000806 implies CCTO:001109" xsd:string ! ESCORT_rule ''Avascular necrosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000806(time_t t0) = EVENT_STATE(CCTO:000806, t0)" xsd:string ! schema ''Avascular necrosis''(time_t t0) = EVENT_STATE(''Avascular necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000807 name: Back pain def: "A disorder characterized by marked discomfort sensation in the back region OR Painful sensation in the back region." [NCI:CTCAE, NCIT:C41830] synonym: "Back pain adverse event" EXACT [NCIT:C56010] xref: UMLS:C0004604 xref: UMLS:C1963071 xref: NCI:CTCAE:10003988 xref: NCIT:C41830 xref: NCIT:C56010 property_value: ESCORT_rule "CCTO:000807 implies CCTO:000107" xsd:string ! ESCORT_rule ''Back pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000807 implies CCTO:001109" xsd:string ! ESCORT_rule ''Back pain'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000807(time_t t0) = EVENT_STATE(CCTO:000807, t0)" xsd:string ! schema ''Back pain''(time_t t0) = EVENT_STATE(''Back pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000808 name: Buttock pain def: "A disorder characterized by marked discomfort sensation in the buttocks OR Painful sensation in the buttocks." [NCI:CTCAE, NCIT:C78228] synonym: "Buttock pain adverse event" EXACT [NCIT:C56030] xref: UMLS:C0231710 xref: UMLS:C1963189 xref: NCI:CTCAE:10048677 xref: NCIT:C56030 xref: NCIT:C78228 property_value: ESCORT_rule "CCTO:000808 implies CCTO:000107" xsd:string ! ESCORT_rule ''Buttock pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000808 implies CCTO:001109" xsd:string ! ESCORT_rule ''Buttock pain'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000808(time_t t0) = EVENT_STATE(CCTO:000808, t0)" xsd:string ! schema ''Buttock pain''(time_t t0) = EVENT_STATE(''Buttock pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000809 name: Chest wall pain def: "Painful sensation in the chest wall region OR A disorder characterized by marked discomfort sensation in the chest wall region." [NCIT:C78238, NCI:CTCAE] synonym: "Chest wall pain adverse event" EXACT [NCIT:C56040] synonym: "Musculoskeletal chest pain" EXACT [NCIT:C78238] xref: UMLS:C0008035 xref: UMLS:C0476280 xref: UMLS:C1963056 xref: NCI:CTCAE:10008496 xref: NCIT:C56040 xref: NCIT:C78238 property_value: ESCORT_rule "CCTO:000809 implies CCTO:000107" xsd:string ! ESCORT_rule ''Chest wall pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000809 implies CCTO:001109" xsd:string ! ESCORT_rule ''Chest wall pain'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000809(time_t t0) = EVENT_STATE(CCTO:000809, t0)" xsd:string ! schema ''Chest wall pain''(time_t t0) = EVENT_STATE(''Chest wall pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000810 name: Exostosis def: "Non-neoplastic overgrowth of bone OR A disorder characterized by non-neoplastic overgrowth of bone." [NCIT:C3029, NCI:CTCAE] synonym: "Bone spur" EXACT [NCIT:C3029] synonym: "Exostosis adverse event" EXACT [NCIT:C58377] xref: UMLS:C1956089 xref: UMLS:C1442903 xref: UMLS:C1961130 xref: NCI:CTCAE:10015688 xref: NCIT:C3029 xref: NCIT:C58377 property_value: ESCORT_rule "CCTO:000810 implies CCTO:000049" xsd:string ! ESCORT_rule ''Exostosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000810 implies CCTO:001109" xsd:string ! ESCORT_rule ''Exostosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000810(time_t t0) = EVENT_STATE(CCTO:000810, t0)" xsd:string ! schema ''Exostosis''(time_t t0) = EVENT_STATE(''Exostosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000811 name: Fibrosis deep connective tissue def: "A disorder characterized by fibrotic degeneration of the deep connective tissues OR Fibrotic degeneration of the deep connective tissues." [NCI:CTCAE, NCIT:C78301] synonym: "Deep connective tissue fibrosis" EXACT [NCIT:C78301] xref: UMLS:C1560030 xref: NCI:CTCAE:10065799 xref: NCIT:C78301 property_value: ESCORT_rule "CCTO:000811 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fibrosis deep connective tissue'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000811 implies CCTO:001109" xsd:string ! ESCORT_rule ''Fibrosis deep connective tissue'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000811(time_t t0) = EVENT_STATE(CCTO:000811, t0)" xsd:string ! schema ''Fibrosis deep connective tissue''(time_t t0) = EVENT_STATE(''Fibrosis deep connective tissue'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000812 name: Flank pain def: "Painful sensation in the region below the ribs and above the hip OR A disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip." [NCIT:C34615, NCI:CTCAE] xref: UMLS:C0016199 xref: NCI:CTCAE:10016750 xref: NCIT:C34615 property_value: ESCORT_rule "CCTO:000812 implies CCTO:000107" xsd:string ! ESCORT_rule ''Flank pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000812 implies CCTO:001109" xsd:string ! ESCORT_rule ''Flank pain'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000812(time_t t0) = EVENT_STATE(CCTO:000812, t0)" xsd:string ! schema ''Flank pain''(time_t t0) = EVENT_STATE(''Flank pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000813 name: Generalized muscle weakness def: "A reduction in the strength of muscles in multiple anatomic sites OR A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites." [NCIT:C78323, NCI:CTCAE] xref: UMLS:C0746674 xref: NCI:CTCAE:10062572 xref: NCIT:C78323 property_value: ESCORT_rule "CCTO:000813 implies CCTO:000049" xsd:string ! ESCORT_rule ''Generalized muscle weakness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000813 implies CCTO:001109" xsd:string ! ESCORT_rule ''Generalized muscle weakness'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000813(time_t t0) = EVENT_STATE(CCTO:000813, t0)" xsd:string ! schema ''Generalized muscle weakness''(time_t t0) = EVENT_STATE(''Generalized muscle weakness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000814 name: Growth suppression def: "A disorder characterized by of stature that is smaller than normal as expected for age OR Stature that is smaller than normal as expected for age." [NCI:CTCAE, NCIT:C78328] synonym: "Growth retardation" EXACT [NCIT:C78328] xref: UMLS:C0151686 xref: NCI:CTCAE:10018761 xref: NCIT:C78328 property_value: ESCORT_rule "CCTO:000814 implies CCTO:000049" xsd:string ! ESCORT_rule ''Growth suppression'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000814 implies CCTO:001109" xsd:string ! ESCORT_rule ''Growth suppression'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000814(time_t t0) = EVENT_STATE(CCTO:000814, t0)" xsd:string ! schema ''Growth suppression''(time_t t0) = EVENT_STATE(''Growth suppression'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000815 name: Head soft tissue necrosis def: "A disorder characterized by a necrotic process occurring in the soft tissues of the head OR A necrotic process affecting the soft tissues of the head." [NCI:CTCAE, NCIT:C78331] synonym: "Head soft tissue necrosis adverse event" EXACT [NCIT:C58383] synonym: "Head soft tissue necrotic lesion" EXACT [NCIT:C78331] xref: UMLS:C1963121 xref: UMLS:C1561246 xref: NCI:CTCAE:10065779 xref: NCIT:C58383 xref: NCIT:C78331 property_value: ESCORT_rule "CCTO:000815 implies CCTO:000049" xsd:string ! ESCORT_rule ''Head soft tissue necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000815 implies CCTO:001109" xsd:string ! ESCORT_rule ''Head soft tissue necrosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000815(time_t t0) = EVENT_STATE(CCTO:000815, t0)" xsd:string ! schema ''Head soft tissue necrosis''(time_t t0) = EVENT_STATE(''Head soft tissue necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000816 name: Joint effusion def: "Abnormally increased amount of fluid in a joint cavity, usually as a result of joint inflammation OR A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation." [NCIT:C49052, NCI:CTCAE] xref: UMLS:C1253936 xref: NCI:CTCAE:10023215 xref: NCIT:C49052 property_value: ESCORT_rule "CCTO:000816 implies CCTO:000049" xsd:string ! ESCORT_rule ''Joint effusion'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000816 implies CCTO:001109" xsd:string ! ESCORT_rule ''Joint effusion'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000816(time_t t0) = EVENT_STATE(CCTO:000816, t0)" xsd:string ! schema ''Joint effusion''(time_t t0) = EVENT_STATE(''Joint effusion'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000817 name: Joint range of motion decreased def: "A disorder characterized by a decrease in joint flexibility of any joint OR Decreased joint flexibility." [NCI:CTCAE, NCIT:C78403] xref: UMLS:C0877027 xref: NCI:CTCAE:10048706 xref: NCIT:C78403 property_value: ESCORT_rule "CCTO:000817 implies CCTO:000049" xsd:string ! ESCORT_rule ''Joint range of motion decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000817 implies CCTO:001109" xsd:string ! ESCORT_rule ''Joint range of motion decreased'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000817(time_t t0) = EVENT_STATE(CCTO:000817, t0)" xsd:string ! schema ''Joint range of motion decreased''(time_t t0) = EVENT_STATE(''Joint range of motion decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000818 name: Joint range of motion decreased cervical spine def: "Decreased flexibility of a cervical spine joint OR A disorder characterized by a decrease in flexibility of a cervical spine joint." [NCIT:C78404, NCI:CTCAE] synonym: "Cervical Spine Joint Range of Motion Decreased" EXACT [NCIT:C78404] xref: UMLS:C1698040 xref: NCI:CTCAE:10065796 xref: NCIT:C78404 property_value: ESCORT_rule "CCTO:000818 implies CCTO:000049" xsd:string ! ESCORT_rule ''Joint range of motion decreased cervical spine'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000818 implies CCTO:001109" xsd:string ! ESCORT_rule ''Joint range of motion decreased cervical spine'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000818(time_t t0) = EVENT_STATE(CCTO:000818, t0)" xsd:string ! schema ''Joint range of motion decreased cervical spine''(time_t t0) = EVENT_STATE(''Joint range of motion decreased cervical spine'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000819 name: Joint range of motion decreased lumbar spine def: "Decreased flexibility of a lumbar spine joint OR A disorder characterized by a decrease in flexibility of a lumbar spine joint." [NCIT:C78405, NCI:CTCAE] synonym: "Lumbar Spine Joint Range of Motion Decreased" EXACT [NCIT:C78405] xref: UMLS:C1699182 xref: NCI:CTCAE:10065800 xref: NCIT:C78405 property_value: ESCORT_rule "CCTO:000819 implies CCTO:000049" xsd:string ! ESCORT_rule ''Joint range of motion decreased lumbar spine'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000819 implies CCTO:001109" xsd:string ! ESCORT_rule ''Joint range of motion decreased lumbar spine'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000819(time_t t0) = EVENT_STATE(CCTO:000819, t0)" xsd:string ! schema ''Joint range of motion decreased lumbar spine''(time_t t0) = EVENT_STATE(''Joint range of motion decreased lumbar spine'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000820 name: Kyphosis def: "Abnormally increased curvature of the thoracic portion of the spine OR A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine." [NCIT:C34754, NCI:CTCAE] xref: UMLS:C0022821 xref: NCI:CTCAE:10023509 xref: NCIT:C34754 property_value: ESCORT_rule "CCTO:000820 implies CCTO:000049" xsd:string ! ESCORT_rule ''Kyphosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000820 implies CCTO:001109" xsd:string ! ESCORT_rule ''Kyphosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000820(time_t t0) = EVENT_STATE(CCTO:000820, t0)" xsd:string ! schema ''Kyphosis''(time_t t0) = EVENT_STATE(''Kyphosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000821 name: Lordosis def: "Abnormally increased curvature of the lumbar portion of the spinal column OR A disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine." [NCIT:C34787, NCI:CTCAE] xref: UMLS:C0024003 xref: NCI:CTCAE:10024842 xref: NCIT:C34787 property_value: ESCORT_rule "CCTO:000821 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lordosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000821 implies CCTO:001109" xsd:string ! ESCORT_rule ''Lordosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000821(time_t t0) = EVENT_STATE(CCTO:000821, t0)" xsd:string ! schema ''Lordosis''(time_t t0) = EVENT_STATE(''Lordosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000822 name: Muscle weakness left-sided def: "A disorder characterized by a reduction in the strength of the muscles on the left side of the body OR A reduction in the strength of the muscles in the left side of the body." [NCI:CTCAE, NCIT:C78455] xref: UMLS:C1698038 xref: NCI:CTCAE:10065780 xref: NCIT:C78455 property_value: ESCORT_rule "CCTO:000822 implies CCTO:000049" xsd:string ! ESCORT_rule ''Muscle weakness left-sided'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000822 implies CCTO:001109" xsd:string ! ESCORT_rule ''Muscle weakness left-sided'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000822(time_t t0) = EVENT_STATE(CCTO:000822, t0)" xsd:string ! schema ''Muscle weakness left-sided''(time_t t0) = EVENT_STATE(''Muscle weakness left-sided'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000823 name: Muscle weakness lower limb def: "A reduction in the strength of the lower limb muscles OR A disorder characterized by a reduction in the strength of the lower limb muscles." [NCIT:C78456, NCI:CTCAE] xref: UMLS:C1698037 xref: NCI:CTCAE:10065776 xref: NCIT:C78456 property_value: ESCORT_rule "CCTO:000823 implies CCTO:000049" xsd:string ! ESCORT_rule ''Muscle weakness lower limb'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000823 implies CCTO:001109" xsd:string ! ESCORT_rule ''Muscle weakness lower limb'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000823(time_t t0) = EVENT_STATE(CCTO:000823, t0)" xsd:string ! schema ''Muscle weakness lower limb''(time_t t0) = EVENT_STATE(''Muscle weakness lower limb'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000824 name: Muscle weakness right-sided def: "A reduction in the strength of the muscles in the right side of the body OR A disorder characterized by a reduction in the strength of the muscles on the right side of the body." [NCIT:C78457, NCI:CTCAE] xref: UMLS:C1699181 xref: NCI:CTCAE:10065794 xref: NCIT:C78457 property_value: ESCORT_rule "CCTO:000824 implies CCTO:000049" xsd:string ! ESCORT_rule ''Muscle weakness right-sided'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000824 implies CCTO:001109" xsd:string ! ESCORT_rule ''Muscle weakness right-sided'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000824(time_t t0) = EVENT_STATE(CCTO:000824, t0)" xsd:string ! schema ''Muscle weakness right-sided''(time_t t0) = EVENT_STATE(''Muscle weakness right-sided'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000825 name: Muscle weakness trunk def: "A disorder characterized by a reduction in the strength of the trunk muscles OR A reduction in the strength of the trunk muscles." [NCI:CTCAE, NCIT:C78458] xref: UMLS:C0241492 xref: NCI:CTCAE:10065795 xref: NCIT:C78458 property_value: ESCORT_rule "CCTO:000825 implies CCTO:000049" xsd:string ! ESCORT_rule ''Muscle weakness trunk'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000825 implies CCTO:001109" xsd:string ! ESCORT_rule ''Muscle weakness trunk'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000825(time_t t0) = EVENT_STATE(CCTO:000825, t0)" xsd:string ! schema ''Muscle weakness trunk''(time_t t0) = EVENT_STATE(''Muscle weakness trunk'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000826 name: Muscle weakness upper limb def: "A disorder characterized by a reduction in the strength of the upper limb muscles OR A reduction in the strength of the upper limb muscles." [NCI:CTCAE, NCIT:C78459] xref: UMLS:C1698196 xref: NCI:CTCAE:10065895 xref: NCIT:C78459 property_value: ESCORT_rule "CCTO:000826 implies CCTO:000049" xsd:string ! ESCORT_rule ''Muscle weakness upper limb'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000826 implies CCTO:001109" xsd:string ! ESCORT_rule ''Muscle weakness upper limb'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000826(time_t t0) = EVENT_STATE(CCTO:000826, t0)" xsd:string ! schema ''Muscle weakness upper limb''(time_t t0) = EVENT_STATE(''Muscle weakness upper limb'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000827 name: Musculoskeletal deformity def: "A disorder characterized by of a malformation of the musculoskeletal system OR Congenital or acquired deformity of the musculoskeletal system." [NCI:CTCAE, NCIT:C78488] xref: UMLS:C0281914 xref: NCI:CTCAE:10065783 xref: NCIT:C78488 property_value: ESCORT_rule "CCTO:000827 implies CCTO:000049" xsd:string ! ESCORT_rule ''Musculoskeletal deformity'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000827 implies CCTO:001109" xsd:string ! ESCORT_rule ''Musculoskeletal deformity'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000827(time_t t0) = EVENT_STATE(CCTO:000827, t0)" xsd:string ! schema ''Musculoskeletal deformity''(time_t t0) = EVENT_STATE(''Musculoskeletal deformity'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000828 name: Myalgia def: "A disorder characterized by marked discomfort sensation originating from a muscle or group of muscles OR Painful sensation originating from a muscle or group of muscles." [NCI:CTCAE, NCIT:C27009] synonym: "Muscle pain" EXACT [NCIT:C27009] xref: UMLS:C0231528 xref: NCI:CTCAE:10028411 xref: NCIT:C27009 property_value: ESCORT_rule "CCTO:000828 implies CCTO:000049" xsd:string ! ESCORT_rule ''Myalgia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000828 implies CCTO:001109" xsd:string ! ESCORT_rule ''Myalgia'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000828(time_t t0) = EVENT_STATE(CCTO:000828, t0)" xsd:string ! schema ''Myalgia''(time_t t0) = EVENT_STATE(''Myalgia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000829 name: Myositis def: "An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders OR A disorder characterized by inflammation involving the skeletal muscles." [NCIT:C27578, NCI:CTCAE] xref: UMLS:C0027121 xref: NCI:CTCAE:10028653 xref: NCIT:C27578 property_value: ESCORT_rule "CCTO:000829 implies CCTO:000049" xsd:string ! ESCORT_rule ''Myositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000829 implies CCTO:001109" xsd:string ! ESCORT_rule ''Myositis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000829(time_t t0) = EVENT_STATE(CCTO:000829, t0)" xsd:string ! schema ''Myositis''(time_t t0) = EVENT_STATE(''Myositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000830 name: Neck pain def: "Painful sensation in the neck area OR A disorder characterized by marked discomfort sensation in the neck area." [NCIT:C50663, NCI:CTCAE] synonym: "Neck pain adverse event" EXACT [NCIT:C56135] synonym: "Pain in neck" EXACT [NCIT:C50663] synonym: "Pain, neck" EXACT [NCIT:C50663] xref: UMLS:C0007859 xref: UMLS:C1963180 xref: NCI:CTCAE:10028836 xref: NCIT:C50663 xref: NCIT:C56135 property_value: ESCORT_rule "CCTO:000830 implies CCTO:000107" xsd:string ! ESCORT_rule ''Neck pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000830 implies CCTO:001109" xsd:string ! ESCORT_rule ''Neck pain'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000830(time_t t0) = EVENT_STATE(CCTO:000830, t0)" xsd:string ! schema ''Neck pain''(time_t t0) = EVENT_STATE(''Neck pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000831 name: Neck soft tissue necrosis def: "A necrotic process affecting the soft tissues of the neck OR A disorder characterized by a necrotic process occurring in the soft tissues of the neck." [NCIT:C78502, NCI:CTCAE] synonym: "Neck soft tissue necrosis adverse event" EXACT [NCIT:C58394] synonym: "Neck soft tissue necrotic lesion" EXACT [NCIT:C78502] xref: UMLS:C1561251 xref: UMLS:C1963181 xref: NCI:CTCAE:10065781 xref: NCIT:C58394 xref: NCIT:C78502 property_value: ESCORT_rule "CCTO:000831 implies CCTO:000049" xsd:string ! ESCORT_rule ''Neck soft tissue necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000831 implies CCTO:001109" xsd:string ! ESCORT_rule ''Neck soft tissue necrosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000831(time_t t0) = EVENT_STATE(CCTO:000831, t0)" xsd:string ! schema ''Neck soft tissue necrosis''(time_t t0) = EVENT_STATE(''Neck soft tissue necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000832 name: Osteonecrosis of jaw def: "A disorder characterized by a necrotic process occurring in the bone of the mandible OR An area of necrotic bone in the mandible or maxilla." [NCI:CTCAE, NCIT:C63924] synonym: "Jaw osteonecrosis" EXACT [NCIT:C63924] synonym: "ONJ" EXACT [NCIT:C63924] xref: UMLS:C2711248 xref: NCI:CTCAE:10064658 xref: NCIT:C63924 property_value: ESCORT_rule "CCTO:000832 implies CCTO:000049" xsd:string ! ESCORT_rule ''Osteonecrosis of jaw'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000832 implies CCTO:001109" xsd:string ! ESCORT_rule ''Osteonecrosis of jaw'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000832(time_t t0) = EVENT_STATE(CCTO:000832, t0)" xsd:string ! schema ''Osteonecrosis of jaw''(time_t t0) = EVENT_STATE(''Osteonecrosis of jaw'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000833 name: Osteoporosis def: "A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss) OR A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence." [NCIT:C3298, NCI:CTCAE] synonym: "Osteoporosis adverse event" EXACT [NCIT:C58396] xref: UMLS:C0029456 xref: UMLS:C1962963 xref: NCI:CTCAE:10031282 xref: NCIT:C3298 xref: NCIT:C58396 property_value: ESCORT_rule "CCTO:000833 implies CCTO:000049" xsd:string ! ESCORT_rule ''Osteoporosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000833 implies CCTO:001109" xsd:string ! ESCORT_rule ''Osteoporosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000833(time_t t0) = EVENT_STATE(CCTO:000833, t0)" xsd:string ! schema ''Osteoporosis''(time_t t0) = EVENT_STATE(''Osteoporosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000834 name: Pain in extremity def: "Painful sensation in the upper or lower extremities OR A disorder characterized by marked discomfort sensation in the upper or lower extremities." [NCIT:C78515, NCI:CTCAE] xref: UMLS:C0030196 xref: NCI:CTCAE:10033425 xref: NCIT:C78515 property_value: ESCORT_rule "CCTO:000834 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pain in extremity'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000834 implies CCTO:001109" xsd:string ! ESCORT_rule ''Pain in extremity'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000834(time_t t0) = EVENT_STATE(CCTO:000834, t0)" xsd:string ! schema ''Pain in extremity''(time_t t0) = EVENT_STATE(''Pain in extremity'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000835 name: Pelvic soft tissue necrosis def: "A necrotic process affecting the soft tissues of the pelvis OR A disorder characterized by a necrotic process occurring in the soft tissues of the pelvis." [NCIT:C78525, NCI:CTCAE] synonym: "Pelvic soft tissue necrosis adverse event" EXACT [NCIT:C58399] synonym: "Pelvic soft tissue necrotic lesion" EXACT [NCIT:C78525] xref: UMLS:C1962964 xref: UMLS:C1561256 xref: NCI:CTCAE:10065793 xref: NCIT:C58399 xref: NCIT:C78525 property_value: ESCORT_rule "CCTO:000835 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pelvic soft tissue necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000835 implies CCTO:001109" xsd:string ! ESCORT_rule ''Pelvic soft tissue necrosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000835(time_t t0) = EVENT_STATE(CCTO:000835, t0)" xsd:string ! schema ''Pelvic soft tissue necrosis''(time_t t0) = EVENT_STATE(''Pelvic soft tissue necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000836 name: Scoliosis def: "A disorder characterized by a malformed, lateral curvature of the spine OR A congenital or acquired spinal deformity characterized by lateral curvature of the spine." [NCI:CTCAE, NCIT:C78603] xref: UMLS:C0036439 xref: NCI:CTCAE:10039722 xref: NCIT:C78603 property_value: ESCORT_rule "CCTO:000836 implies CCTO:000049" xsd:string ! ESCORT_rule ''Scoliosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000836 implies CCTO:001109" xsd:string ! ESCORT_rule ''Scoliosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000836(time_t t0) = EVENT_STATE(CCTO:000836, t0)" xsd:string ! schema ''Scoliosis''(time_t t0) = EVENT_STATE(''Scoliosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000837 name: Soft tissue necrosis lower limb def: "A disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity OR A necrotic process affecting the soft tissues of the lower extremity." [NCI:CTCAE, NCIT:C78620] synonym: "Lower limb soft tissue necrotic lesion" EXACT [NCIT:C78620] xref: UMLS:C1698668 xref: NCI:CTCAE:10065777 xref: NCIT:C78620 property_value: ESCORT_rule "CCTO:000837 implies CCTO:000049" xsd:string ! ESCORT_rule ''Soft tissue necrosis lower limb'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000837 implies CCTO:001109" xsd:string ! ESCORT_rule ''Soft tissue necrosis lower limb'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000837(time_t t0) = EVENT_STATE(CCTO:000837, t0)" xsd:string ! schema ''Soft tissue necrosis lower limb''(time_t t0) = EVENT_STATE(''Soft tissue necrosis lower limb'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000838 name: Soft tissue necrosis upper limb def: "A disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity OR A necrotic process affecting the soft tissues of the upper extremity." [NCI:CTCAE, NCIT:C78621] synonym: "Upper limb soft tissue necrotic lesion" EXACT [NCIT:C78621] xref: UMLS:C1698634 xref: NCI:CTCAE:10065778 xref: NCIT:C78621 property_value: ESCORT_rule "CCTO:000838 implies CCTO:000049" xsd:string ! ESCORT_rule ''Soft tissue necrosis upper limb'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000838 implies CCTO:001109" xsd:string ! ESCORT_rule ''Soft tissue necrosis upper limb'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000838(time_t t0) = EVENT_STATE(CCTO:000838, t0)" xsd:string ! schema ''Soft tissue necrosis upper limb''(time_t t0) = EVENT_STATE(''Soft tissue necrosis upper limb'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000839 name: Superficial soft tissue fibrosis def: "Fibrotic degeneration of the superficial soft tissues OR A disorder characterized by fibrotic degeneration of the superficial soft tissues." [NCIT:C78633, NCI:CTCAE] xref: UMLS:C1698669 xref: NCI:CTCAE:10065798 xref: NCIT:C78633 property_value: ESCORT_rule "CCTO:000839 implies CCTO:000049" xsd:string ! ESCORT_rule ''Superficial soft tissue fibrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000839 implies CCTO:001109" xsd:string ! ESCORT_rule ''Superficial soft tissue fibrosis'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000839(time_t t0) = EVENT_STATE(CCTO:000839, t0)" xsd:string ! schema ''Superficial soft tissue fibrosis''(time_t t0) = EVENT_STATE(''Superficial soft tissue fibrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000840 name: Trismus def: "A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication OR Lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication. It may be a symptom of tetanus." [NCI:CTCAE, NCIT:C78651] xref: UMLS:C0041105 xref: NCI:CTCAE:10044684 xref: NCIT:C78651 property_value: ESCORT_rule "CCTO:000840 implies CCTO:000049" xsd:string ! ESCORT_rule ''Trismus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000840 implies CCTO:001109" xsd:string ! ESCORT_rule ''Trismus'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000840(time_t t0) = EVENT_STATE(CCTO:000840, t0)" xsd:string ! schema ''Trismus''(time_t t0) = EVENT_STATE(''Trismus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000841 name: Unequal limb length def: "A disorder characterized by of a discrepancy between the lengths of the lower or upper extremities OR Discrepancy between the lengths of the lower or upper extremities." [NCI:CTCAE, NCIT:C78657] xref: UMLS:C0494930 xref: NCI:CTCAE:10065738 xref: NCIT:C78657 property_value: ESCORT_rule "CCTO:000841 implies CCTO:000049" xsd:string ! ESCORT_rule ''Unequal limb length'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000841 implies CCTO:001109" xsd:string ! ESCORT_rule ''Unequal limb length'' implies ''Musculoskeletal and connective tissue disorders'' property_value: schema "CCTO:000841(time_t t0) = EVENT_STATE(CCTO:000841, t0)" xsd:string ! schema ''Unequal limb length''(time_t t0) = EVENT_STATE(''Unequal limb length'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001109 ! Musculoskeletal and connective tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000842 name: Leukemia secondary to oncology chemotherapy def: "A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor OR A disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents." [NCIT:C80691, NCI:CTCAE] synonym: "Chemotherapy-related leukemia" EXACT [NCIT:C80691] xref: UMLS:C0863127 xref: NCI:CTCAE:10048293 xref: NCIT:C80691 property_value: ESCORT_rule "CCTO:000842 implies CCTO:000049" xsd:string ! ESCORT_rule ''Leukemia secondary to oncology chemotherapy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000842 implies CCTO:001122" xsd:string ! ESCORT_rule ''Leukemia secondary to oncology chemotherapy'' implies ''Neoplasms benign, malignant and unspecified (incl cysts and polyps)'' property_value: schema "CCTO:000842(time_t t0) = EVENT_STATE(CCTO:000842, t0)" xsd:string ! schema ''Leukemia secondary to oncology chemotherapy''(time_t t0) = EVENT_STATE(''Leukemia secondary to oncology chemotherapy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001122 ! Neoplasms benign, malignant and unspecified (incl cysts and polyps) relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000843 name: Myelodysplastic syndrome def: "Myelodysplastic Syndrome is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology OR A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) OR A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow." [NCIT:C103128, NCIT:C3247, NCI:CTCAE] synonym: "Dysmyelopoietic syndrome" EXACT [NCIT:C3247] synonym: "Hematopoeitic - Myelodysplastic Syndrome (MDS)" EXACT [NCIT:C3247] synonym: "MDS" EXACT [NCIT:C3247] synonym: "Myelodysplasia" EXACT [NCIT:C3247] synonym: "Myelodysplastic neoplasm" EXACT [NCIT:C3247] synonym: "Myelodysplastic syndrome/neoplasm" EXACT [NCIT:C3247] synonym: "Myelodysplastic syndrome, NOS" EXACT [NCIT:C3247] synonym: "NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology" EXACT [NCIT:C103128] synonym: "NCI CTEP Simple Disease Classification Myelodysplastic Syndrome Sub-Category Terminology" EXACT [NCIT:C103128] synonym: "Oligoblastic leukemia" EXACT [NCIT:C3247] synonym: "Preleukemia" EXACT [NCIT:C3247] synonym: "Smoldering leukemia" EXACT [NCIT:C3247] synonym: "myelodysplastic syndromes" EXACT [NCIT:C3247] xref: UMLS:C0026986 xref: UMLS:C0033027 xref: UMLS:C3538995 xref: UMLS:C0002894 xref: UMLS:C0026985 xref: UMLS:C3463824 xref: UMLS:C2698684 xref: NCI:CTCAE:10028533 xref: NCIT:C103128 xref: NCIT:C3247 property_value: ESCORT_rule "CCTO:000843 implies CCTO:000049" xsd:string ! ESCORT_rule ''Myelodysplastic syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000843 implies CCTO:001122" xsd:string ! ESCORT_rule ''Myelodysplastic syndrome'' implies ''Neoplasms benign, malignant and unspecified (incl cysts and polyps)'' property_value: schema "CCTO:000843(time_t t0) = EVENT_STATE(CCTO:000843, t0)" xsd:string ! schema ''Myelodysplastic syndrome''(time_t t0) = EVENT_STATE(''Myelodysplastic syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001122 ! Neoplasms benign, malignant and unspecified (incl cysts and polyps) relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000844 name: Treatment related secondary malignancy def: "The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself OR A disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy." [NCIT:C4969, NCI:CTCAE] synonym: "Iatrogenic cancer" EXACT [NCIT:C4969] synonym: "Therapy related cancer" EXACT [NCIT:C4969] synonym: "Therapy related malignant neoplasm" EXACT [NCIT:C4969] synonym: "Therapy related malignant tumor" EXACT [NCIT:C4969] synonym: "Therapy-related malignant neoplasm" EXACT [NCIT:C4969] xref: UMLS:C0877578 xref: NCI:CTCAE:10049737 xref: NCIT:C4969 property_value: ESCORT_rule "CCTO:000844 implies CCTO:000049" xsd:string ! ESCORT_rule ''Treatment related secondary malignancy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000844 implies CCTO:001122" xsd:string ! ESCORT_rule ''Treatment related secondary malignancy'' implies ''Neoplasms benign, malignant and unspecified (incl cysts and polyps)'' property_value: schema "CCTO:000844(time_t t0) = EVENT_STATE(CCTO:000844, t0)" xsd:string ! schema ''Treatment related secondary malignancy''(time_t t0) = EVENT_STATE(''Treatment related secondary malignancy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001122 ! Neoplasms benign, malignant and unspecified (incl cysts and polyps) relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000845 name: Tumor pain def: "A painful sensation caused by the tumor growth OR A disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis." [NCIT:C78656, NCI:CTCAE] synonym: "Tumor pain adverse event" EXACT [NCIT:C56245] xref: UMLS:C0854069 xref: UMLS:C1963255 xref: NCI:CTCAE:10045158 xref: NCIT:C56245 xref: NCIT:C78656 property_value: ESCORT_rule "CCTO:000845 implies CCTO:000107" xsd:string ! ESCORT_rule ''Tumor pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000845 implies CCTO:001122" xsd:string ! ESCORT_rule ''Tumor pain'' implies ''Neoplasms benign, malignant and unspecified (incl cysts and polyps)'' property_value: schema "CCTO:000845(time_t t0) = EVENT_STATE(CCTO:000845, t0)" xsd:string ! schema ''Tumor pain''(time_t t0) = EVENT_STATE(''Tumor pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001122 ! Neoplasms benign, malignant and unspecified (incl cysts and polyps) relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000846 name: Abducens nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the abducens nerve (sixth cranial nerve) OR A disorder characterized by involvement of the abducens nerve (sixth cranial nerve)." [NCIT:C27593, NCI:CTCAE] synonym: "Abducens nerve disease" EXACT [NCIT:C27593] synonym: "VIth Nerve Disorder" EXACT [NCIT:C27593] xref: UMLS:C0271355 xref: NCI:CTCAE:10053662 xref: NCIT:C27593 property_value: ESCORT_rule "CCTO:000846 implies CCTO:000049" xsd:string ! ESCORT_rule ''Abducens nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000846 implies CCTO:001123" xsd:string ! ESCORT_rule ''Abducens nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000846(time_t t0) = EVENT_STATE(CCTO:000846, t0)" xsd:string ! schema ''Abducens nerve disorder''(time_t t0) = EVENT_STATE(''Abducens nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000847 name: Accessory nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the accessory nerve (eleventh cranial nerve) OR A disorder characterized by involvement of the accessory nerve (eleventh cranial nerve)." [NCIT:C26953, NCI:CTCAE] synonym: "Disorder of 11th Nerve" EXACT [NCIT:C26953] synonym: "Disorder of the 11th Nerve" EXACT [NCIT:C26953] synonym: "Eleventh nerve disorder" EXACT [NCIT:C26953] xref: UMLS:C0152180 xref: NCI:CTCAE:10060929 xref: NCIT:C26953 property_value: ESCORT_rule "CCTO:000847 implies CCTO:000049" xsd:string ! ESCORT_rule ''Accessory nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000847 implies CCTO:001123" xsd:string ! ESCORT_rule ''Accessory nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000847(time_t t0) = EVENT_STATE(CCTO:000847, t0)" xsd:string ! schema ''Accessory nerve disorder''(time_t t0) = EVENT_STATE(''Accessory nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000848 name: Acoustic nerve disorder NOS def: "A disorder characterized by involvement of the acoustic nerve (eighth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the acoustic nerve." [NCI:CTCAE, NCIT:C27207] synonym: "Acoustic nerve disorder" EXACT [NCIT:C27207] synonym: "Vestibulocochlear nerve disorder" EXACT [NCIT:C27207] xref: UMLS:C0001163 xref: UMLS:C0750885 xref: NCI:CTCAE:10000521 xref: NCIT:C27207 property_value: ESCORT_rule "CCTO:000848 implies CCTO:000049" xsd:string ! ESCORT_rule ''Acoustic nerve disorder NOS'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000848 implies CCTO:001123" xsd:string ! ESCORT_rule ''Acoustic nerve disorder NOS'' implies ''Nervous system disorders'' property_value: schema "CCTO:000848(time_t t0) = EVENT_STATE(CCTO:000848, t0)" xsd:string ! schema ''Acoustic nerve disorder NOS''(time_t t0) = EVENT_STATE(''Acoustic nerve disorder NOS'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000849 name: Akathisia def: "An uncomfortable feeling of inner restlessness and inability to stay still. It can be a side effect of psychotropic medications OR A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs." [NCIT:C78163, NCI:CTCAE] xref: UMLS:C0392156 xref: NCI:CTCAE:10001540 xref: NCIT:C78163 property_value: ESCORT_rule "CCTO:000849 implies CCTO:000049" xsd:string ! ESCORT_rule ''Akathisia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000849 implies CCTO:001123" xsd:string ! ESCORT_rule ''Akathisia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000849(time_t t0) = EVENT_STATE(CCTO:000849, t0)" xsd:string ! schema ''Akathisia''(time_t t0) = EVENT_STATE(''Akathisia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000850 name: Amnesia def: "A disorder characterized by systematic and extensive loss of memory OR Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories." [NCI:CTCAE, NCIT:C2867] synonym: "Loss of memory" EXACT [NCIT:C2867] synonym: "Memory loss" EXACT [NCIT:C2867] xref: UMLS:C0002622 xref: UMLS:C0751295 xref: NCI:CTCAE:10001949 xref: NCIT:C2867 property_value: ESCORT_rule "CCTO:000850 implies CCTO:000049" xsd:string ! ESCORT_rule ''Amnesia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000850 implies CCTO:001123" xsd:string ! ESCORT_rule ''Amnesia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000850(time_t t0) = EVENT_STATE(CCTO:000850, t0)" xsd:string ! schema ''Amnesia''(time_t t0) = EVENT_STATE(''Amnesia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000851 name: Aphonia def: "A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic) OR A term referring to the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic)." [NCI:CTCAE, NCIT:C79539] xref: UMLS:C0003564 xref: NCI:CTCAE:10002953 xref: NCIT:C79539 property_value: ESCORT_rule "CCTO:000851 implies CCTO:000049" xsd:string ! ESCORT_rule ''Aphonia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000851 implies CCTO:001123" xsd:string ! ESCORT_rule ''Aphonia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000851(time_t t0) = EVENT_STATE(CCTO:000851, t0)" xsd:string ! schema ''Aphonia''(time_t t0) = EVENT_STATE(''Aphonia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000852 name: Arachnoiditis def: "A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space OR Inflammation of the arachnoid membrane and adjacent subarachnoid space." [NCI:CTCAE, NCIT:C37913] xref: UMLS:C0003708 xref: NCI:CTCAE:10003074 xref: NCIT:C37913 property_value: ESCORT_rule "CCTO:000852 implies CCTO:000049" xsd:string ! ESCORT_rule ''Arachnoiditis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000852 implies CCTO:001123" xsd:string ! ESCORT_rule ''Arachnoiditis'' implies ''Nervous system disorders'' property_value: schema "CCTO:000852(time_t t0) = EVENT_STATE(CCTO:000852, t0)" xsd:string ! schema ''Arachnoiditis''(time_t t0) = EVENT_STATE(''Arachnoiditis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000853 name: Ataxia def: "Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders OR A disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities." [NCIT:C26702, NCI:CTCAE] xref: UMLS:C0004134 xref: NCI:CTCAE:10003591 xref: NCIT:C26702 property_value: ESCORT_rule "CCTO:000853 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ataxia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000853 implies CCTO:001123" xsd:string ! ESCORT_rule ''Ataxia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000853(time_t t0) = EVENT_STATE(CCTO:000853, t0)" xsd:string ! schema ''Ataxia''(time_t t0) = EVENT_STATE(''Ataxia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000854 name: Brachial plexopathy def: "A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand OR A brachial plexus disorder characterized by regional paresthesia, pain and muscle weakness, and limited movement in the arm or hand." [NCI:CTCAE, NCIT:C27194] synonym: "Brachial plexopathy adverse event" EXACT [NCIT:C55356] synonym: "Brachial plexus neuropathy" EXACT [NCIT:C27194] xref: UMLS:C0700251 xref: UMLS:C1963078 xref: NCI:CTCAE:10065417 xref: NCIT:C27194 xref: NCIT:C55356 property_value: ESCORT_rule "CCTO:000854 implies CCTO:000049" xsd:string ! ESCORT_rule ''Brachial plexopathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000854 implies CCTO:001123" xsd:string ! ESCORT_rule ''Brachial plexopathy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000854(time_t t0) = EVENT_STATE(CCTO:000854, t0)" xsd:string ! schema ''Brachial plexopathy''(time_t t0) = EVENT_STATE(''Brachial plexopathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000855 name: Central nervous system necrosis def: "A disorder characterized by a necrotic process occurring in the brain and/or spinal cord OR A necrotic process affecting the brain and/or spinal cord." [NCI:CTCAE, NCIT:C78236] synonym: "Central nervous system necrotic lesion" EXACT [NCIT:C78236] xref: UMLS:C1392207 xref: NCI:CTCAE:10065784 xref: NCIT:C78236 property_value: ESCORT_rule "CCTO:000855 implies CCTO:000049" xsd:string ! ESCORT_rule ''Central nervous system necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000855 implies CCTO:001123" xsd:string ! ESCORT_rule ''Central nervous system necrosis'' implies ''Nervous system disorders'' property_value: schema "CCTO:000855(time_t t0) = EVENT_STATE(CCTO:000855, t0)" xsd:string ! schema ''Central nervous system necrosis''(time_t t0) = EVENT_STATE(''Central nervous system necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000856 name: Cerebrospinal fluid leakage def: "A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues OR The loss of cerebrospinal fluid into the surrounding tissues." [NCI:CTCAE, NCIT:C50487] synonym: "Fluid, leakage of cerebrospinal" EXACT [NCIT:C50487] synonym: "Leakage of cerebrospinal fluid" EXACT [NCIT:C50487] xref: UMLS:C0023182 xref: UMLS:C2936821 xref: NCI:CTCAE:10008164 xref: NCIT:C50487 property_value: ESCORT_rule "CCTO:000856 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cerebrospinal fluid leakage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000856 implies CCTO:001123" xsd:string ! ESCORT_rule ''Cerebrospinal fluid leakage'' implies ''Nervous system disorders'' property_value: schema "CCTO:000856(time_t t0) = EVENT_STATE(CCTO:000856, t0)" xsd:string ! schema ''Cerebrospinal fluid leakage''(time_t t0) = EVENT_STATE(''Cerebrospinal fluid leakage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000857 name: Cognitive disturbance def: "A notable change in cognitive function OR A disorder characterized by a conspicuous change in cognitive function." [NCIT:C27101, NCI:CTCAE] synonym: "Cognitive disturbance adverse event" EXACT [NCIT:C55373] synonym: "Neurocognitive disturbance" EXACT [NCIT:C27101] xref: UMLS:C0338656 xref: UMLS:C1963144 xref: NCI:CTCAE:10009845 xref: NCIT:C27101 xref: NCIT:C55373 property_value: ESCORT_rule "CCTO:000857 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cognitive disturbance'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000857 implies CCTO:001123" xsd:string ! ESCORT_rule ''Cognitive disturbance'' implies ''Nervous system disorders'' property_value: schema "CCTO:000857(time_t t0) = EVENT_STATE(CCTO:000857, t0)" xsd:string ! schema ''Cognitive disturbance''(time_t t0) = EVENT_STATE(''Cognitive disturbance'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000858 name: Concentration impairment def: "A disorder characterized by a deterioration in the ability to concentrate OR Deterioration in the ability to concentrate." [NCI:CTCAE, NCIT:C80081] xref: UMLS:C0235198 xref: NCI:CTCAE:10010250 xref: NCIT:C80081 property_value: ESCORT_rule "CCTO:000858 implies CCTO:000049" xsd:string ! ESCORT_rule ''Concentration impairment'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000858 implies CCTO:001123" xsd:string ! ESCORT_rule ''Concentration impairment'' implies ''Nervous system disorders'' property_value: schema "CCTO:000858(time_t t0) = EVENT_STATE(CCTO:000858, t0)" xsd:string ! schema ''Concentration impairment''(time_t t0) = EVENT_STATE(''Concentration impairment'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000859 name: Depressed level of consciousness def: "A neurologic state characterized by decreased ability to perceive and respond OR A disorder characterized by a decrease in ability to perceive and respond." [NCIT:C78253, NCI:CTCAE] synonym: "DEPRESSED" EXACT [NCIT:C78253] xref: UMLS:C0549249 xref: UMLS:C0344315 xref: NCI:CTCAE:10012373 xref: NCIT:C78253 property_value: ESCORT_rule "CCTO:000859 implies CCTO:000049" xsd:string ! ESCORT_rule ''Depressed level of consciousness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000859 implies CCTO:001123" xsd:string ! ESCORT_rule ''Depressed level of consciousness'' implies ''Nervous system disorders'' property_value: schema "CCTO:000859(time_t t0) = EVENT_STATE(CCTO:000859, t0)" xsd:string ! schema ''Depressed level of consciousness''(time_t t0) = EVENT_STATE(''Depressed level of consciousness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000860 name: Dizziness def: "A question about the usual severity of an individual's dizziness OR A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking OR A sensation of lightheadedness, unsteadiness, turning, spinning or rocking OR A question about whether an individual has or had dizziness OR A question about how often an individual feels or felt dizzy OR A question about an individual's distress from their dizziness." [NCIT:C125319, NCI:CTCAE, NCIT:C37943, NCIT:C125409, NCIT:C125287, NCIT:C125351] synonym: "Dizziness adverse event" EXACT [NCIT:C55385] synonym: "Dizzy frequency" EXACT [NCIT:C125287] synonym: "Dizzy" EXACT [NCIT:C37943] synonym: "Frequency of Dizziness" EXACT [NCIT:C125287] synonym: "Have been dizzy" EXACT [NCIT:C125409] synonym: "Have dizziness" EXACT [NCIT:C125409] synonym: "How much distress dizziness" EXACT [NCIT:C125351] synonym: "How often dizzy" EXACT [NCIT:C125287] synonym: "Lightheadedness" EXACT [NCIT:C37943] synonym: "Usual severity dizziness" EXACT [NCIT:C125319] xref: UMLS:C0012833 xref: UMLS:C0220870 xref: UMLS:C1963093 xref: NCI:CTCAE:10013573 xref: NCIT:C125287 xref: NCIT:C125319 xref: NCIT:C125351 xref: NCIT:C125409 xref: NCIT:C37943 xref: NCIT:C55385 property_value: ESCORT_rule "CCTO:000860 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dizziness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000860 implies CCTO:001123" xsd:string ! ESCORT_rule ''Dizziness'' implies ''Nervous system disorders'' property_value: schema "CCTO:000860(time_t t0) = EVENT_STATE(CCTO:000860, t0)" xsd:string ! schema ''Dizziness''(time_t t0) = EVENT_STATE(''Dizziness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000861 name: Dysarthria def: "Slow and slurred speech resulting from inability to coordinate the muscles that are used in speech. Causes include brain damage, Parkinson disease, and developmental causes OR A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech." [NCIT:C79549, NCI:CTCAE] xref: UMLS:C0013362 xref: NCI:CTCAE:10013887 xref: NCIT:C79549 property_value: ESCORT_rule "CCTO:000861 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dysarthria'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000861 implies CCTO:001123" xsd:string ! ESCORT_rule ''Dysarthria'' implies ''Nervous system disorders'' property_value: schema "CCTO:000861(time_t t0) = EVENT_STATE(CCTO:000861, t0)" xsd:string ! schema ''Dysarthria''(time_t t0) = EVENT_STATE(''Dysarthria'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000862 name: Dysesthesia def: "A disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation OR Distortion of a sense resulting in an abnormal and unpleasant sensation, usually described as burning, tingling, or numbness. Causes include lesions of the nervous system." [NCI:CTCAE, NCIT:C28246] xref: UMLS:C0392699 xref: NCI:CTCAE:10062872 xref: NCIT:C28246 property_value: ESCORT_rule "CCTO:000862 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dysesthesia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000862 implies CCTO:001123" xsd:string ! ESCORT_rule ''Dysesthesia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000862(time_t t0) = EVENT_STATE(CCTO:000862, t0)" xsd:string ! schema ''Dysesthesia''(time_t t0) = EVENT_STATE(''Dysesthesia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000863 name: Dysgeusia def: "Persistence of unpleasant taste OR A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell." [NCIT:C28145, NCI:CTCAE] synonym: "parageusia" EXACT [NCIT:C28145] xref: UMLS:C0013378 xref: NCI:CTCAE:10013911 xref: NCIT:C28145 property_value: ESCORT_rule "CCTO:000863 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dysgeusia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000863 implies CCTO:001123" xsd:string ! ESCORT_rule ''Dysgeusia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000863(time_t t0) = EVENT_STATE(CCTO:000863, t0)" xsd:string ! schema ''Dysgeusia''(time_t t0) = EVENT_STATE(''Dysgeusia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000864 name: Dysphasia def: "A disorder characterized by impairment of verbal communication skills, often resulting from brain damage OR Impairment of verbal communication skills, often resulting from brain damage." [NCI:CTCAE, NCIT:C35546] xref: UMLS:C0973461 xref: NCI:CTCAE:10013951 xref: NCIT:C35546 property_value: ESCORT_rule "CCTO:000864 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dysphasia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000864 implies CCTO:001123" xsd:string ! ESCORT_rule ''Dysphasia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000864(time_t t0) = EVENT_STATE(CCTO:000864, t0)" xsd:string ! schema ''Dysphasia''(time_t t0) = EVENT_STATE(''Dysphasia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000865 name: Edema cerebral def: "Swelling due to an excessive accumulation of fluid in the brain OR A disorder characterized by swelling due to an excessive accumulation of fluid in the brain." [NCIT:C4909, NCI:CTCAE] synonym: "Cerebral edema" EXACT [NCIT:C4909] synonym: "edema, cerebral" EXACT [NCIT:C4909] xref: UMLS:C0006114 xref: NCI:CTCAE:10014217 xref: NCIT:C4909 property_value: ESCORT_rule "CCTO:000865 implies CCTO:000049" xsd:string ! ESCORT_rule ''Edema cerebral'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000865 implies CCTO:001123" xsd:string ! ESCORT_rule ''Edema cerebral'' implies ''Nervous system disorders'' property_value: schema "CCTO:000865(time_t t0) = EVENT_STATE(CCTO:000865, t0)" xsd:string ! schema ''Edema cerebral''(time_t t0) = EVENT_STATE(''Edema cerebral'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000866 name: Encephalopathy def: "A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries OR A disorder characterized by a pathologic process involving the brain." [NCIT:C26920, NCI:CTCAE] synonym: "Encephalopathy adverse event" EXACT [NCIT:C55390] xref: UMLS:C0085584 xref: UMLS:C1963101 xref: NCI:CTCAE:10014625 xref: NCIT:C26920 xref: NCIT:C55390 property_value: ESCORT_rule "CCTO:000866 implies CCTO:000049" xsd:string ! ESCORT_rule ''Encephalopathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000866 implies CCTO:001123" xsd:string ! ESCORT_rule ''Encephalopathy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000866(time_t t0) = EVENT_STATE(CCTO:000866, t0)" xsd:string ! schema ''Encephalopathy''(time_t t0) = EVENT_STATE(''Encephalopathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000867 name: Extrapyramidal disorder def: "A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness OR A movement disorder caused by defects in the basal ganglia. The clinical manifestations include changes in the muscle tone, dyskinesia, and akinesia. Causes include vascular disorders, degenerative disorders, and antipsychotic drugs." [NCI:CTCAE, NCIT:C79593] xref: UMLS:C0015371 xref: NCI:CTCAE:10015832 xref: NCIT:C79593 property_value: ESCORT_rule "CCTO:000867 implies CCTO:000049" xsd:string ! ESCORT_rule ''Extrapyramidal disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000867 implies CCTO:001123" xsd:string ! ESCORT_rule ''Extrapyramidal disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000867(time_t t0) = EVENT_STATE(CCTO:000867, t0)" xsd:string ! schema ''Extrapyramidal disorder''(time_t t0) = EVENT_STATE(''Extrapyramidal disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000868 name: Facial muscle weakness def: "A reduction in the strength of the facial muscles OR A disorder characterized by a reduction in the strength of the facial muscles." [NCIT:C78290, NCI:CTCAE] xref: UMLS:C0427055 xref: NCI:CTCAE:10051272 xref: NCIT:C78290 property_value: ESCORT_rule "CCTO:000868 implies CCTO:000049" xsd:string ! ESCORT_rule ''Facial muscle weakness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000868 implies CCTO:001123" xsd:string ! ESCORT_rule ''Facial muscle weakness'' implies ''Nervous system disorders'' property_value: schema "CCTO:000868(time_t t0) = EVENT_STATE(CCTO:000868, t0)" xsd:string ! schema ''Facial muscle weakness''(time_t t0) = EVENT_STATE(''Facial muscle weakness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000869 name: Facial nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the facial nerve (seventh cranial nerve) OR A disorder characterized by involvement of the facial nerve (seventh cranial nerve)." [NCIT:C27594, NCI:CTCAE] xref: UMLS:C0015464 xref: UMLS:C0015469 xref: NCI:CTCAE:10061457 xref: NCIT:C27594 property_value: ESCORT_rule "CCTO:000869 implies CCTO:000049" xsd:string ! ESCORT_rule ''Facial nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000869 implies CCTO:001123" xsd:string ! ESCORT_rule ''Facial nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000869(time_t t0) = EVENT_STATE(CCTO:000869, t0)" xsd:string ! schema ''Facial nerve disorder''(time_t t0) = EVENT_STATE(''Facial nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000870 name: Glossopharyngeal nerve disorder def: "A disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the glossopharyngeal nerve (ninth cranial nerve)." [NCI:CTCAE, NCIT:C27211] synonym: "IX Nerve Disorder" EXACT [NCIT:C27211] synonym: "Ninth nerve disorder" EXACT [NCIT:C27211] xref: UMLS:C0751941 xref: NCI:CTCAE:10061185 xref: NCIT:C27211 property_value: ESCORT_rule "CCTO:000870 implies CCTO:000049" xsd:string ! ESCORT_rule ''Glossopharyngeal nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000870 implies CCTO:001123" xsd:string ! ESCORT_rule ''Glossopharyngeal nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000870(time_t t0) = EVENT_STATE(CCTO:000870, t0)" xsd:string ! schema ''Glossopharyngeal nerve disorder''(time_t t0) = EVENT_STATE(''Glossopharyngeal nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000871 name: Headache def: "A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve OR Pain in various parts of the head, not confined to the area of distribution of any nerve." [NCI:CTCAE, NCIT:C34661] xref: UMLS:C0018681 xref: NCI:CTCAE:10019211 xref: NCIT:C34661 property_value: ESCORT_rule "CCTO:000871 implies CCTO:000049" xsd:string ! ESCORT_rule ''Headache'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000871 implies CCTO:001123" xsd:string ! ESCORT_rule ''Headache'' implies ''Nervous system disorders'' property_value: schema "CCTO:000871(time_t t0) = EVENT_STATE(CCTO:000871, t0)" xsd:string ! schema ''Headache''(time_t t0) = EVENT_STATE(''Headache'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000872 name: Hydrocephalus def: "A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain OR A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain." [NCI:CTCAE, NCIT:C3111] synonym: "Hydrocephalus adverse event" EXACT [NCIT:C55401] xref: UMLS:C1963137 xref: UMLS:C0020255 xref: NCI:CTCAE:10020508 xref: NCIT:C3111 xref: NCIT:C55401 property_value: ESCORT_rule "CCTO:000872 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hydrocephalus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000872 implies CCTO:001123" xsd:string ! ESCORT_rule ''Hydrocephalus'' implies ''Nervous system disorders'' property_value: schema "CCTO:000872(time_t t0) = EVENT_STATE(CCTO:000872, t0)" xsd:string ! schema ''Hydrocephalus''(time_t t0) = EVENT_STATE(''Hydrocephalus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000873 name: Hypersomnia def: "A disorder characterized by characterized by excessive sleepiness during the daytime OR A sleep disorder characterized by excessive sleepiness." [NCI:CTCAE, NCIT:C78346] xref: UMLS:C0917799 xref: NCI:CTCAE:10020765 xref: NCIT:C78346 property_value: ESCORT_rule "CCTO:000873 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypersomnia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000873 implies CCTO:001123" xsd:string ! ESCORT_rule ''Hypersomnia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000873(time_t t0) = EVENT_STATE(CCTO:000873, t0)" xsd:string ! schema ''Hypersomnia''(time_t t0) = EVENT_STATE(''Hypersomnia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000874 name: Hypoglossal nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the hypoglossal nerve (twelfth cranial nerve) OR A disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve)." [NCIT:C26954, NCI:CTCAE] synonym: "Disorder of XII Nerve" EXACT [NCIT:C26954] synonym: "Disorder of the XII Nerve" EXACT [NCIT:C26954] synonym: "Twelfth nerve disorder" EXACT [NCIT:C26954] xref: UMLS:C0152181 xref: NCI:CTCAE:10061212 xref: NCIT:C26954 property_value: ESCORT_rule "CCTO:000874 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypoglossal nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000874 implies CCTO:001123" xsd:string ! ESCORT_rule ''Hypoglossal nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000874(time_t t0) = EVENT_STATE(CCTO:000874, t0)" xsd:string ! schema ''Hypoglossal nerve disorder''(time_t t0) = EVENT_STATE(''Hypoglossal nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000875 name: Intracranial hemorrhage def: "A disorder characterized by bleeding from the cranium OR Bleeding within the cranium." [NCI:CTCAE, NCIT:C50438] synonym: "Bleeding, intracranial" EXACT [NCIT:C50438] synonym: "Hemorrhage, intracranial" EXACT [NCIT:C50438] synonym: "Intracranial bleeding" EXACT [NCIT:C50438] xref: UMLS:C0151699 xref: NCI:CTCAE:10022763 xref: NCIT:C50438 property_value: ESCORT_rule "CCTO:000875 implies CCTO:000049" xsd:string ! ESCORT_rule ''Intracranial hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000875 implies CCTO:001123" xsd:string ! ESCORT_rule ''Intracranial hemorrhage'' implies ''Nervous system disorders'' property_value: schema "CCTO:000875(time_t t0) = EVENT_STATE(CCTO:000875, t0)" xsd:string ! schema ''Intracranial hemorrhage''(time_t t0) = EVENT_STATE(''Intracranial hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000876 name: Ischemia cerebrovascular def: "A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage OR Diminished or absent blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurologic damage." [NCI:CTCAE, NCIT:C78394] synonym: "Cerebrovascular ischemia" EXACT [NCIT:C78394] xref: UMLS:C0917798 xref: NCI:CTCAE:10023030 xref: NCIT:C78394 property_value: ESCORT_rule "CCTO:000876 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ischemia cerebrovascular'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000876 implies CCTO:001123" xsd:string ! ESCORT_rule ''Ischemia cerebrovascular'' implies ''Nervous system disorders'' property_value: schema "CCTO:000876(time_t t0) = EVENT_STATE(CCTO:000876, t0)" xsd:string ! schema ''Ischemia cerebrovascular''(time_t t0) = EVENT_STATE(''Ischemia cerebrovascular'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000877 name: IVth nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the trochlear nerve (IVth cranial nerve) OR A disorder characterized by involvement of the trochlear nerve (fourth cranial nerve)." [NCIT:C78395, NCI:CTCAE] synonym: "IVth Cranial Nerve Disorder" EXACT [NCIT:C78395] synonym: "Trochlear nerve disorder" EXACT [NCIT:C78395] xref: UMLS:C0271375 xref: NCI:CTCAE:10065836 xref: NCIT:C78395 property_value: ESCORT_rule "CCTO:000877 implies CCTO:000049" xsd:string ! ESCORT_rule ''IVth nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000877 implies CCTO:001123" xsd:string ! ESCORT_rule ''IVth nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000877(time_t t0) = EVENT_STATE(CCTO:000877, t0)" xsd:string ! schema ''IVth nerve disorder''(time_t t0) = EVENT_STATE(''IVth nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000878 name: Lethargy def: "Decreased consciousness characterized by mental and physical inertness OR A disorder characterized by a decrease in consciousness characterized by mental and physical inertness." [NCIT:C78416, NCI:CTCAE] synonym: "Listless" EXACT [NCIT:C78416] xref: UMLS:C0023380 xref: UMLS:C0085632 xref: NCI:CTCAE:10024264 xref: NCIT:C78416 property_value: ESCORT_rule "CCTO:000878 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lethargy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000878 implies CCTO:001123" xsd:string ! ESCORT_rule ''Lethargy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000878(time_t t0) = EVENT_STATE(CCTO:000878, t0)" xsd:string ! schema ''Lethargy''(time_t t0) = EVENT_STATE(''Lethargy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000879 name: Leukoencephalopathy def: "White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation OR A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation." [NCIT:C27059, NCI:CTCAE] xref: UMLS:C0270612 xref: NCI:CTCAE:10024382 xref: NCIT:C27059 property_value: ESCORT_rule "CCTO:000879 implies CCTO:000049" xsd:string ! ESCORT_rule ''Leukoencephalopathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000879 implies CCTO:001123" xsd:string ! ESCORT_rule ''Leukoencephalopathy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000879(time_t t0) = EVENT_STATE(CCTO:000879, t0)" xsd:string ! schema ''Leukoencephalopathy''(time_t t0) = EVENT_STATE(''Leukoencephalopathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000880 name: Memory impairment def: "Deterioration in memory function OR A disorder characterized by a deterioration in memory function." [NCIT:C78444, NCI:CTCAE] synonym: "Memory impairment adverse event" EXACT [NCIT:C55427] xref: UMLS:C0233794 xref: UMLS:C1963167 xref: NCI:CTCAE:10027175 xref: NCIT:C55427 xref: NCIT:C78444 property_value: ESCORT_rule "CCTO:000880 implies CCTO:000049" xsd:string ! ESCORT_rule ''Memory impairment'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000880 implies CCTO:001123" xsd:string ! ESCORT_rule ''Memory impairment'' implies ''Nervous system disorders'' property_value: schema "CCTO:000880(time_t t0) = EVENT_STATE(CCTO:000880, t0)" xsd:string ! schema ''Memory impairment''(time_t t0) = EVENT_STATE(''Memory impairment'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000881 name: Meningismus def: "The symptoms of neck stiffness, headache, and photophobia resulting from meningeal irritation. Causes include subarachnoid hemorrhage and acute febrile diseases OR A disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges." [NCIT:C79694, NCI:CTCAE] synonym: "meningeal syndrome" EXACT [NCIT:C79694] xref: UMLS:C0025287 xref: NCI:CTCAE:10027198 xref: NCIT:C79694 property_value: ESCORT_rule "CCTO:000881 implies CCTO:000049" xsd:string ! ESCORT_rule ''Meningismus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000881 implies CCTO:001123" xsd:string ! ESCORT_rule ''Meningismus'' implies ''Nervous system disorders'' property_value: schema "CCTO:000881(time_t t0) = EVENT_STATE(CCTO:000881, t0)" xsd:string ! schema ''Meningismus''(time_t t0) = EVENT_STATE(''Meningismus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000882 name: Movements involuntary def: "A disorder characterized by uncontrolled and purposeless movements OR Uncontrolled and purposeless movements." [NCI:CTCAE, NCIT:C78453] synonym: "Involuntary movements" EXACT [NCIT:C78453] xref: UMLS:C0427086 xref: NCI:CTCAE:10028041 xref: NCIT:C78453 property_value: ESCORT_rule "CCTO:000882 implies CCTO:000049" xsd:string ! ESCORT_rule ''Movements involuntary'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000882 implies CCTO:001123" xsd:string ! ESCORT_rule ''Movements involuntary'' implies ''Nervous system disorders'' property_value: schema "CCTO:000882(time_t t0) = EVENT_STATE(CCTO:000882, t0)" xsd:string ! schema ''Movements involuntary''(time_t t0) = EVENT_STATE(''Movements involuntary'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000883 name: Myelitis def: "An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence OR A disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence." [NCIT:C26832, NCI:CTCAE] synonym: "Myelitis adverse event" EXACT [NCIT:C55459] xref: UMLS:C1963178 xref: UMLS:C0026975 xref: NCI:CTCAE:10028524 xref: NCIT:C26832 xref: NCIT:C55459 property_value: ESCORT_rule "CCTO:000883 implies CCTO:000049" xsd:string ! ESCORT_rule ''Myelitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000883 implies CCTO:001123" xsd:string ! ESCORT_rule ''Myelitis'' implies ''Nervous system disorders'' property_value: schema "CCTO:000883(time_t t0) = EVENT_STATE(CCTO:000883, t0)" xsd:string ! schema ''Myelitis''(time_t t0) = EVENT_STATE(''Myelitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000884 name: Neuralgia def: "Intense painful sensation along a nerve or group of nerves. It is caused by irritation or trauma to a nerve or inflammation of a nerve OR A disorder characterized by intense painful sensation along a nerve or group of nerves." [NCIT:C79695, NCI:CTCAE] xref: UMLS:C0027796 xref: NCI:CTCAE:10029223 xref: NCIT:C79695 property_value: ESCORT_rule "CCTO:000884 implies CCTO:000049" xsd:string ! ESCORT_rule ''Neuralgia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000884 implies CCTO:001123" xsd:string ! ESCORT_rule ''Neuralgia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000884(time_t t0) = EVENT_STATE(CCTO:000884, t0)" xsd:string ! schema ''Neuralgia''(time_t t0) = EVENT_STATE(''Neuralgia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000885 name: Nystagmus def: "Involuntary movements of the eyeballs. The presence or absence of nystagmus is often used in the diagnosis of a variety of neurological and visual disorders OR A disorder characterized by involuntary movements of the eyeballs." [NCIT:C3282, NCI:CTCAE] synonym: "Nystagmus adverse event" EXACT [NCIT:C55857] xref: UMLS:C1963184 xref: UMLS:C0028738 xref: NCI:CTCAE:10029864 xref: NCIT:C3282 xref: NCIT:C55857 property_value: ESCORT_rule "CCTO:000885 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nystagmus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000885 implies CCTO:001123" xsd:string ! ESCORT_rule ''Nystagmus'' implies ''Nervous system disorders'' property_value: schema "CCTO:000885(time_t t0) = EVENT_STATE(CCTO:000885, t0)" xsd:string ! schema ''Nystagmus''(time_t t0) = EVENT_STATE(''Nystagmus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000886 name: Oculomotor nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the oculomotor nerve (third cranial nerve) OR A disorder characterized by involvement of the oculomotor nerve (third cranial nerve)." [NCIT:C27598, NCI:CTCAE] xref: UMLS:C0271353 xref: UMLS:C0028866 xref: NCI:CTCAE:10053661 xref: NCIT:C27598 property_value: ESCORT_rule "CCTO:000886 implies CCTO:000049" xsd:string ! ESCORT_rule ''Oculomotor nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000886 implies CCTO:001123" xsd:string ! ESCORT_rule ''Oculomotor nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000886(time_t t0) = EVENT_STATE(CCTO:000886, t0)" xsd:string ! schema ''Oculomotor nerve disorder''(time_t t0) = EVENT_STATE(''Oculomotor nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000887 name: Olfactory nerve disorder def: "A disorder characterized by involvement of the olfactory nerve (first cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the olfactory nerve (first cranial nerve)." [NCI:CTCAE, NCIT:C27210] synonym: "Disorder of 1st Nerve" EXACT [NCIT:C27210] synonym: "Disorder of the 1st Nerve" EXACT [NCIT:C27210] xref: UMLS:C0751937 xref: NCI:CTCAE:10056388 xref: NCIT:C27210 property_value: ESCORT_rule "CCTO:000887 implies CCTO:000049" xsd:string ! ESCORT_rule ''Olfactory nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000887 implies CCTO:001123" xsd:string ! ESCORT_rule ''Olfactory nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000887(time_t t0) = EVENT_STATE(CCTO:000887, t0)" xsd:string ! schema ''Olfactory nerve disorder''(time_t t0) = EVENT_STATE(''Olfactory nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000888 name: Paresthesia def: "Abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that an individual experiences without the presence of a stimulus. It results from functional disturbances of sensory neurons. Causes include peripheral vascular disease, peripheral neuropathy, and nerve damage OR A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus." [NCIT:C28177, NCI:CTCAE] xref: UMLS:C0030554 xref: NCI:CTCAE:10033987 xref: NCIT:C28177 property_value: ESCORT_rule "CCTO:000888 implies CCTO:000049" xsd:string ! ESCORT_rule ''Paresthesia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000888 implies CCTO:001123" xsd:string ! ESCORT_rule ''Paresthesia'' implies ''Nervous system disorders'' property_value: schema "CCTO:000888(time_t t0) = EVENT_STATE(CCTO:000888, t0)" xsd:string ! schema ''Paresthesia''(time_t t0) = EVENT_STATE(''Paresthesia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000889 name: Peripheral motor neuropathy def: "A disorder characterized by inflammation or degeneration of the peripheral motor nerves OR Inflammation or degeneration of the peripheral motor nerves." [NCI:CTCAE, NCIT:C3500] xref: UMLS:C0235025 xref: NCI:CTCAE:10034580 xref: NCIT:C3500 property_value: ESCORT_rule "CCTO:000889 implies CCTO:000049" xsd:string ! ESCORT_rule ''Peripheral motor neuropathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000889 implies CCTO:001123" xsd:string ! ESCORT_rule ''Peripheral motor neuropathy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000889(time_t t0) = EVENT_STATE(CCTO:000889, t0)" xsd:string ! schema ''Peripheral motor neuropathy''(time_t t0) = EVENT_STATE(''Peripheral motor neuropathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000890 name: Peripheral sensory neuropathy def: "Inflammation or degeneration of the sensory nerves OR A disorder characterized by inflammation or degeneration of the peripheral sensory nerves." [NCIT:C3501, NCI:CTCAE] xref: UMLS:C0151313 xref: NCI:CTCAE:10034620 xref: NCIT:C3501 property_value: ESCORT_rule "CCTO:000890 implies CCTO:000049" xsd:string ! ESCORT_rule ''Peripheral sensory neuropathy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000890 implies CCTO:001123" xsd:string ! ESCORT_rule ''Peripheral sensory neuropathy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000890(time_t t0) = EVENT_STATE(CCTO:000890, t0)" xsd:string ! schema ''Peripheral sensory neuropathy''(time_t t0) = EVENT_STATE(''Peripheral sensory neuropathy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000891 name: Phantom pain def: "A disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body OR Painful sensation related to a limb or an organ that is removed from or is not physically part of the body." [NCI:CTCAE, NCIT:C79703] xref: UMLS:C3495442 xref: UMLS:C0031315 xref: NCI:CTCAE:10056238 xref: NCIT:C79703 property_value: ESCORT_rule "CCTO:000891 implies CCTO:000107" xsd:string ! ESCORT_rule ''Phantom pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000891 implies CCTO:001123" xsd:string ! ESCORT_rule ''Phantom pain'' implies ''Nervous system disorders'' property_value: schema "CCTO:000891(time_t t0) = EVENT_STATE(CCTO:000891, t0)" xsd:string ! schema ''Phantom pain''(time_t t0) = EVENT_STATE(''Phantom pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000892 name: Presyncope def: "A disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope OR An episode of lightheadedness and dizziness which may precede an episode of syncope." [NCI:CTCAE, NCIT:C80100] xref: UMLS:C0700200 xref: NCI:CTCAE:10036653 xref: NCIT:C80100 property_value: ESCORT_rule "CCTO:000892 implies CCTO:000049" xsd:string ! ESCORT_rule ''Presyncope'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000892 implies CCTO:001123" xsd:string ! ESCORT_rule ''Presyncope'' implies ''Nervous system disorders'' property_value: schema "CCTO:000892(time_t t0) = EVENT_STATE(CCTO:000892, t0)" xsd:string ! schema ''Presyncope''(time_t t0) = EVENT_STATE(''Presyncope'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000893 name: Pyramidal tract syndrome def: "Dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include increased muscle tone in the lower extremities, hyperreflexia, positive Babinski, and decreased fine motor coordination OR A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination." [NCIT:C43245, NCI:CTCAE] synonym: "Dysfunction of the Pyramidal Tract" EXACT [NCIT:C43245] synonym: "Pyramidal tract dysfunction" EXACT [NCIT:C43245] xref: UMLS:C1504405 xref: NCI:CTCAE:10063636 xref: NCIT:C43245 property_value: ESCORT_rule "CCTO:000893 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pyramidal tract syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000893 implies CCTO:001123" xsd:string ! ESCORT_rule ''Pyramidal tract syndrome'' implies ''Nervous system disorders'' property_value: schema "CCTO:000893(time_t t0) = EVENT_STATE(CCTO:000893, t0)" xsd:string ! schema ''Pyramidal tract syndrome''(time_t t0) = EVENT_STATE(''Pyramidal tract syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000894 name: Radiculitis def: "An inflammatory process affecting a nerve root. Patients experience pain radiating along a nerve path because of spinal pressure on the nerve root that connects to the nerve path OR A disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root." [NCIT:C78581, NCI:CTCAE] xref: UMLS:C0034544 xref: NCI:CTCAE:10061928 xref: NCIT:C78581 property_value: ESCORT_rule "CCTO:000894 implies CCTO:000049" xsd:string ! ESCORT_rule ''Radiculitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000894 implies CCTO:001123" xsd:string ! ESCORT_rule ''Radiculitis'' implies ''Nervous system disorders'' property_value: schema "CCTO:000894(time_t t0) = EVENT_STATE(CCTO:000894, t0)" xsd:string ! schema ''Radiculitis''(time_t t0) = EVENT_STATE(''Radiculitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000895 name: Recurrent laryngeal nerve palsy def: "Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis OR A disorder characterized by paralysis of the recurrent laryngeal nerve." [NCIT:C78592, NCI:CTCAE] synonym: "Recurrent laryngeal nerve paralysis" EXACT [NCIT:C78592] synonym: "Vagus nerve laryngeal paralysis" EXACT [NCIT:C78592] xref: UMLS:C0542142 xref: NCI:CTCAE:10038130 xref: NCIT:C78592 property_value: ESCORT_rule "CCTO:000895 implies CCTO:000049" xsd:string ! ESCORT_rule ''Recurrent laryngeal nerve palsy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000895 implies CCTO:001123" xsd:string ! ESCORT_rule ''Recurrent laryngeal nerve palsy'' implies ''Nervous system disorders'' property_value: schema "CCTO:000895(time_t t0) = EVENT_STATE(CCTO:000895, t0)" xsd:string ! schema ''Recurrent laryngeal nerve palsy''(time_t t0) = EVENT_STATE(''Recurrent laryngeal nerve palsy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000896 name: Reversible posterior leukoencephalopathy syndrome def: "A disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition OR An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment." [NCI:CTCAE, NCIT:C78598] synonym: "PRES" EXACT [NCIT:C78598] synonym: "Posterior reversible encephalopathy syndrome" EXACT [NCIT:C78598] synonym: "RPLE" EXACT [NCIT:C78598] synonym: "Reversible occipital parietal encephalopathy" EXACT [NCIT:C78598] synonym: "Reversible posterior cerebral edema syndrome" EXACT [NCIT:C78598] xref: UMLS:C3160858 xref: UMLS:C0033095 xref: UMLS:C1822756 xref: NCI:CTCAE:10063761 xref: NCIT:C78598 property_value: ESCORT_rule "CCTO:000896 implies CCTO:000049" xsd:string ! ESCORT_rule ''Reversible posterior leukoencephalopathy syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000896 implies CCTO:001123" xsd:string ! ESCORT_rule ''Reversible posterior leukoencephalopathy syndrome'' implies ''Nervous system disorders'' property_value: schema "CCTO:000896(time_t t0) = EVENT_STATE(CCTO:000896, t0)" xsd:string ! schema ''Reversible posterior leukoencephalopathy syndrome''(time_t t0) = EVENT_STATE(''Reversible posterior leukoencephalopathy syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000897 name: Seizure def: "A disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin OR Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin." [NCI:CTCAE, NCIT:C2962] synonym: "Convulsion" EXACT [NCIT:C2962] synonym: "Seizure adverse event" EXACT [NCIT:C55578] synonym: "Seizures" EXACT [NCIT:C2962] xref: UMLS:C0036572 xref: UMLS:C1959629 xref: NCI:CTCAE:10039906 xref: NCIT:C2962 xref: NCIT:C55578 property_value: ESCORT_rule "CCTO:000897 implies CCTO:000049" xsd:string ! ESCORT_rule ''Seizure'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000897 implies CCTO:001123" xsd:string ! ESCORT_rule ''Seizure'' implies ''Nervous system disorders'' property_value: schema "CCTO:000897(time_t t0) = EVENT_STATE(CCTO:000897, t0)" xsd:string ! schema ''Seizure''(time_t t0) = EVENT_STATE(''Seizure'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000898 name: Sinus pain def: "Painful sensation in the face, between the eyes, or upper teeth originating from the sinuses. It is usually caused by sinus infections OR A disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses." [NCIT:C78609, NCI:CTCAE] synonym: "Sinus pain adverse event" EXACT [NCIT:C56220] xref: UMLS:C0522251 xref: UMLS:C1963236 xref: NCI:CTCAE:10040747 xref: NCIT:C56220 xref: NCIT:C78609 property_value: ESCORT_rule "CCTO:000898 implies CCTO:000107" xsd:string ! ESCORT_rule ''Sinus pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000898 implies CCTO:001123" xsd:string ! ESCORT_rule ''Sinus pain'' implies ''Nervous system disorders'' property_value: schema "CCTO:000898(time_t t0) = EVENT_STATE(CCTO:000898, t0)" xsd:string ! schema ''Sinus pain''(time_t t0) = EVENT_STATE(''Sinus pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000899 name: Somnolence def: "A disorder characterized by characterized by excessive sleepiness and drowsiness OR A sleep disorder characterized by excessive sleepiness and drowsiness." [NCI:CTCAE, NCIT:C26754] xref: UMLS:C2830004 xref: NCI:CTCAE:10041349 xref: NCIT:C26754 property_value: ESCORT_rule "CCTO:000899 implies CCTO:000049" xsd:string ! ESCORT_rule ''Somnolence'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000899 implies CCTO:001123" xsd:string ! ESCORT_rule ''Somnolence'' implies ''Nervous system disorders'' property_value: schema "CCTO:000899(time_t t0) = EVENT_STATE(CCTO:000899, t0)" xsd:string ! schema ''Somnolence''(time_t t0) = EVENT_STATE(''Somnolence'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000900 name: Spasticity def: "Increased involuntary muscle tone caused by central nervous system disorders that affect the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. Representative examples of disorders causing spasticity include brain or spinal cord injury, and multiple sclerosis OR A disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances." [NCIT:C79750, NCI:CTCAE] synonym: "Spastic" EXACT [NCIT:C79750] xref: UMLS:C0026838 xref: UMLS:C0443306 xref: NCI:CTCAE:10041416 xref: NCIT:C79750 property_value: ESCORT_rule "CCTO:000900 implies CCTO:000049" xsd:string ! ESCORT_rule ''Spasticity'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000900 implies CCTO:001123" xsd:string ! ESCORT_rule ''Spasticity'' implies ''Nervous system disorders'' property_value: schema "CCTO:000900(time_t t0) = EVENT_STATE(CCTO:000900, t0)" xsd:string ! schema ''Spasticity''(time_t t0) = EVENT_STATE(''Spasticity'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000901 name: Stroke def: "A disorder characterized by a sudden loss of sensory function due to an intracranial vascular event OR A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event." [NCI:CTCAE, NCIT:C3390] synonym: "CVA" EXACT [NCIT:C3390] synonym: "CVA, Cerebrovascular Accident" EXACT [NCIT:C3390] synonym: "Cerebral infarction" EXACT [NCIT:C3390] synonym: "Cerebrovascular accident" EXACT [NCIT:C3390] synonym: "Cerebrovascular Accident, (CVA)" EXACT [NCIT:C3390] synonym: "Stroke syndrome" EXACT [NCIT:C3390] synonym: "Syndrome, stroke" EXACT [NCIT:C3390] synonym: "UNDETERMINED STROKE" EXACT [NCIT:C3390] xref: UMLS:C0038454 xref: UMLS:C0007785 xref: UMLS:C0001365 xref: UMLS:C0054889 xref: UMLS:C1263853 xref: NCI:CTCAE:10042244 xref: NCIT:C3390 property_value: ESCORT_rule "CCTO:000901 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stroke'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000901 implies CCTO:001123" xsd:string ! ESCORT_rule ''Stroke'' implies ''Nervous system disorders'' property_value: schema "CCTO:000901(time_t t0) = EVENT_STATE(CCTO:000901, t0)" xsd:string ! schema ''Stroke''(time_t t0) = EVENT_STATE(''Stroke'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000902 name: Syncope def: "A spontaneous loss of consciousness caused by insufficient blood supply to the brain OR A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain." [NCIT:C35053, NCI:CTCAE] synonym: "Faint" EXACT [NCIT:C35053] synonym: "Fainting" EXACT [NCIT:C35053] xref: UMLS:C0039070 xref: UMLS:C3541349 xref: NCI:CTCAE:10042772 xref: NCIT:C35053 property_value: ESCORT_rule "CCTO:000902 implies CCTO:000049" xsd:string ! ESCORT_rule ''Syncope'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000902 implies CCTO:001123" xsd:string ! ESCORT_rule ''Syncope'' implies ''Nervous system disorders'' property_value: schema "CCTO:000902(time_t t0) = EVENT_STATE(CCTO:000902, t0)" xsd:string ! schema ''Syncope''(time_t t0) = EVENT_STATE(''Syncope'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000903 name: Transient ischemic attacks def: "A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit OR A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit." [NCI:CTCAE, NCIT:C50781] synonym: "Attack, transient ischemic" EXACT [NCIT:C50781] synonym: "Ischemic attack, transient" EXACT [NCIT:C50781] synonym: "TIA" EXACT [NCIT:C50781] synonym: "Transient ischemic attack" EXACT [NCIT:C50781] xref: UMLS:C0007787 xref: UMLS:C1054154 xref: NCI:CTCAE:10044391 xref: NCIT:C50781 property_value: ESCORT_rule "CCTO:000903 implies CCTO:000049" xsd:string ! ESCORT_rule ''Transient ischemic attacks'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000903 implies CCTO:001123" xsd:string ! ESCORT_rule ''Transient ischemic attacks'' implies ''Nervous system disorders'' property_value: schema "CCTO:000903(time_t t0) = EVENT_STATE(CCTO:000903, t0)" xsd:string ! schema ''Transient ischemic attacks''(time_t t0) = EVENT_STATE(''Transient ischemic attacks'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000904 name: Tremor def: "The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action OR A disorder characterized by the uncontrolled shaking movement of the whole body or individual parts." [NCIT:C38038, NCI:CTCAE] synonym: "Shaking" EXACT [NCIT:C38038] synonym: "Shaking/tremors" EXACT [NCIT:C38038] synonym: "Tremor adverse event" EXACT [NCIT:C55596] synonym: "Tremors/shaking" EXACT [NCIT:C38038] xref: UMLS:C0040822 xref: UMLS:C1963252 xref: NCI:CTCAE:10044565 xref: NCIT:C38038 xref: NCIT:C55596 property_value: ESCORT_rule "CCTO:000904 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tremor'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000904 implies CCTO:001123" xsd:string ! ESCORT_rule ''Tremor'' implies ''Nervous system disorders'' property_value: schema "CCTO:000904(time_t t0) = EVENT_STATE(CCTO:000904, t0)" xsd:string ! schema ''Tremor''(time_t t0) = EVENT_STATE(''Tremor'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000905 name: Trigeminal nerve disorder def: "A non-neoplastic or neoplastic disorder affecting the trigeminal nerve (fifth cranial nerve) OR A disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve)." [NCIT:C26952, NCI:CTCAE] xref: UMLS:C0152177 xref: NCI:CTCAE:10060890 xref: NCIT:C26952 property_value: ESCORT_rule "CCTO:000905 implies CCTO:000049" xsd:string ! ESCORT_rule ''Trigeminal nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000905 implies CCTO:001123" xsd:string ! ESCORT_rule ''Trigeminal nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000905(time_t t0) = EVENT_STATE(CCTO:000905, t0)" xsd:string ! schema ''Trigeminal nerve disorder''(time_t t0) = EVENT_STATE(''Trigeminal nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000906 name: Vagus nerve disorder def: "A disorder characterized by involvement of the vagus nerve (tenth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the vagus nerve (tenth cranial nerve)." [NCI:CTCAE, NCIT:C27591] xref: UMLS:C0152179 xref: NCI:CTCAE:10061403 xref: NCIT:C27591 property_value: ESCORT_rule "CCTO:000906 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vagus nerve disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000906 implies CCTO:001123" xsd:string ! ESCORT_rule ''Vagus nerve disorder'' implies ''Nervous system disorders'' property_value: schema "CCTO:000906(time_t t0) = EVENT_STATE(CCTO:000906, t0)" xsd:string ! schema ''Vagus nerve disorder''(time_t t0) = EVENT_STATE(''Vagus nerve disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000907 name: Vasovagal reaction def: "A disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve OR Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated." [NCI:CTCAE, NCIT:C50798] synonym: "Vaso-vagal response" EXACT [NCIT:C50798] synonym: "Vasovagal response" EXACT [NCIT:C50798] xref: UMLS:C1710621 xref: UMLS:C0042420 xref: NCI:CTCAE:10047166 xref: NCIT:C50798 property_value: ESCORT_rule "CCTO:000907 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vasovagal reaction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000907 implies CCTO:001123" xsd:string ! ESCORT_rule ''Vasovagal reaction'' implies ''Nervous system disorders'' property_value: schema "CCTO:000907(time_t t0) = EVENT_STATE(CCTO:000907, t0)" xsd:string ! schema ''Vasovagal reaction''(time_t t0) = EVENT_STATE(''Vasovagal reaction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001123 ! Nervous system disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000908 name: Fetal death def: "Death of a fetus after 10 weeks gestation OR A disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation." [NCIT:C50620, NCI:CTCAE] synonym: "Death, intrauterine fetal" EXACT [NCIT:C50620] synonym: "Fetal death, intrauterine" EXACT [NCIT:C50620] synonym: "Fetal demise" EXACT [NCIT:C50620] synonym: "INTRAUTERINE DEATH" EXACT [NCIT:C50620] synonym: "IUD" EXACT [NCIT:C50620] synonym: "Intrauterine fetal death" EXACT [NCIT:C50620] xref: UMLS:C0015927 xref: UMLS:C0595939 xref: UMLS:C0021900 xref: NCI:CTCAE:10016479 xref: NCIT:C50620 property_value: ESCORT_rule "CCTO:000908 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fetal death'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000908 implies CCTO:001124" xsd:string ! ESCORT_rule ''Fetal death'' implies ''Pregnancy, puerperium and perinatal conditions'' property_value: schema "CCTO:000908(time_t t0) = EVENT_STATE(CCTO:000908, t0)" xsd:string ! schema ''Fetal death''(time_t t0) = EVENT_STATE(''Fetal death'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001124 ! Pregnancy, puerperium and perinatal conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000909 name: Fetal growth retardation def: "A disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight OR A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age." [NCI:CTCAE, NCIT:C114875] synonym: "Fetal growth restriction" EXACT [NCIT:C114875] synonym: "Fetal SGA" EXACT [NCIT:C114875] synonym: "Fetal Small for Gestational Age" EXACT [NCIT:C114875] synonym: "Fetus Small for Gestational Age" EXACT [NCIT:C114875] synonym: "IUGR" EXACT [NCIT:C114875] synonym: "Intrauterine growth restriction" EXACT [NCIT:C114875] synonym: "Intrauterine growth retardation" EXACT [NCIT:C114875] synonym: "Intrauterine growth retardation" EXACT [NCIT:C80083] xref: UMLS:C0015934 xref: NCI:CTCAE:10054746 xref: NCIT:C114875 xref: NCIT:C80083 property_value: ESCORT_rule "CCTO:000909 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fetal growth retardation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000909 implies CCTO:001124" xsd:string ! ESCORT_rule ''Fetal growth retardation'' implies ''Pregnancy, puerperium and perinatal conditions'' property_value: schema "CCTO:000909(time_t t0) = EVENT_STATE(CCTO:000909, t0)" xsd:string ! schema ''Fetal growth retardation''(time_t t0) = EVENT_STATE(''Fetal growth retardation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001124 ! Pregnancy, puerperium and perinatal conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000910 name: Premature delivery def: "Birth when a fetus is less than 37 weeks and 0 days gestational age OR A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation." [NCIT:C92861, NCI:CTCAE] synonym: "Pre-term" EXACT [NCIT:C92861] synonym: "Preterm birth" EXACT [NCIT:C92861] synonym: "Preterm delivery" EXACT [NCIT:C92861] xref: UMLS:C0151526 xref: NCI:CTCAE:10036595 xref: NCIT:C92861 property_value: ESCORT_rule "CCTO:000910 implies CCTO:000049" xsd:string ! ESCORT_rule ''Premature delivery'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000910 implies CCTO:001124" xsd:string ! ESCORT_rule ''Premature delivery'' implies ''Pregnancy, puerperium and perinatal conditions'' property_value: schema "CCTO:000910(time_t t0) = EVENT_STATE(CCTO:000910, t0)" xsd:string ! schema ''Premature delivery''(time_t t0) = EVENT_STATE(''Premature delivery'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001124 ! Pregnancy, puerperium and perinatal conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000911 name: Unintended pregnancy def: "A pregnancy that was not desired or was timed incorrectly at the time that the conception occurred OR A disorder characterized by an unexpected pregnancy at the time of conception." [NCIT:C79801, NCI:CTCAE] xref: UMLS:C0041747 xref: NCI:CTCAE:10045542 xref: NCIT:C79801 property_value: ESCORT_rule "CCTO:000911 implies CCTO:000049" xsd:string ! ESCORT_rule ''Unintended pregnancy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000911 implies CCTO:001124" xsd:string ! ESCORT_rule ''Unintended pregnancy'' implies ''Pregnancy, puerperium and perinatal conditions'' property_value: schema "CCTO:000911(time_t t0) = EVENT_STATE(CCTO:000911, t0)" xsd:string ! schema ''Unintended pregnancy''(time_t t0) = EVENT_STATE(''Unintended pregnancy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001124 ! Pregnancy, puerperium and perinatal conditions relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000912 name: Agitation def: "A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension OR A state of restlessness associated with unpleasant feelings of irritability and tension. Causes include pain, stress, fever, alcohol and nicotine withdrawal, cocaine and hallucinogenic drugs use, depression, bipolar disorders, and schizophrenia." [NCI:CTCAE, NCIT:C79530] synonym: "Agitation adverse event" EXACT [NCIT:C55435] xref: UMLS:C0085631 xref: UMLS:C1963060 xref: NCI:CTCAE:10001497 xref: NCIT:C55435 xref: NCIT:C79530 property_value: ESCORT_rule "CCTO:000912 implies CCTO:000049" xsd:string ! ESCORT_rule ''Agitation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000912 implies CCTO:001105" xsd:string ! ESCORT_rule ''Agitation'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000912(time_t t0) = EVENT_STATE(CCTO:000912, t0)" xsd:string ! schema ''Agitation''(time_t t0) = EVENT_STATE(''Agitation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000913 name: Anorgasmia def: "Inability to achieve orgasm OR A disorder characterized by an inability to achieve orgasm." [NCIT:C78177, NCI:CTCAE] xref: UMLS:C0234022 xref: NCI:CTCAE:10002652 xref: NCIT:C78177 property_value: ESCORT_rule "CCTO:000913 implies CCTO:000049" xsd:string ! ESCORT_rule ''Anorgasmia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000913 implies CCTO:001105" xsd:string ! ESCORT_rule ''Anorgasmia'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000913(time_t t0) = EVENT_STATE(CCTO:000913, t0)" xsd:string ! schema ''Anorgasmia''(time_t t0) = EVENT_STATE(''Anorgasmia'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000914 name: Confusion def: "A mental state characterized by a lack of clear and orderly thought and behavior OR A disorder characterized by a lack of clear and orderly thought and behavior." [NCIT:C37928, NCI:CTCAE] synonym: "Confusion adverse event" EXACT [NCIT:C55379] synonym: "Confusion/disorientation" EXACT [NCIT:C37928] synonym: "Disorientation" EXACT [NCIT:C37928] synonym: "Disorientation/confusion" EXACT [NCIT:C37928] xref: UMLS:C0009676 xref: UMLS:C0233407 xref: UMLS:C1963086 xref: NCI:CTCAE:10010300 xref: NCIT:C37928 xref: NCIT:C55379 property_value: ESCORT_rule "CCTO:000914 implies CCTO:000049" xsd:string ! ESCORT_rule ''Confusion'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000914 implies CCTO:001105" xsd:string ! ESCORT_rule ''Confusion'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000914(time_t t0) = EVENT_STATE(CCTO:000914, t0)" xsd:string ! schema ''Confusion''(time_t t0) = EVENT_STATE(''Confusion'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000915 name: Delayed orgasm def: "A disorder characterized by sexual dysfunction characterized by a delay in climax OR Sexual dysfunction characterized by a delay in climax." [NCI:CTCAE, NCIT:C78252] xref: UMLS:C1112573 xref: NCI:CTCAE:10057066 xref: NCIT:C78252 property_value: ESCORT_rule "CCTO:000915 implies CCTO:000049" xsd:string ! ESCORT_rule ''Delayed orgasm'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000915 implies CCTO:001105" xsd:string ! ESCORT_rule ''Delayed orgasm'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000915(time_t t0) = EVENT_STATE(CCTO:000915, t0)" xsd:string ! schema ''Delayed orgasm''(time_t t0) = EVENT_STATE(''Delayed orgasm'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000916 name: Delirium def: "A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition OR A usually reversible condition characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Causes include drug abuse, poisoning, infectious processes, and fluid and electrolyte imbalance." [NCI:CTCAE, NCIT:C2981] xref: UMLS:C0011206 xref: NCI:CTCAE:10012218 xref: NCIT:C2981 property_value: ESCORT_rule "CCTO:000916 implies CCTO:000049" xsd:string ! ESCORT_rule ''Delirium'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000916 implies CCTO:001105" xsd:string ! ESCORT_rule ''Delirium'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000916(time_t t0) = EVENT_STATE(CCTO:000916, t0)" xsd:string ! schema ''Delirium''(time_t t0) = EVENT_STATE(''Delirium'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000917 name: Delusions def: "A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense OR False personal beliefs held contrary to reality, despite contradictory evidence and common sense." [NCI:CTCAE, NCIT:C26741] synonym: "Delusion" EXACT [NCIT:C26741] xref: UMLS:C0011253 xref: NCI:CTCAE:10012260 xref: NCIT:C26741 property_value: ESCORT_rule "CCTO:000917 implies CCTO:000049" xsd:string ! ESCORT_rule ''Delusions'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000917 implies CCTO:001105" xsd:string ! ESCORT_rule ''Delusions'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000917(time_t t0) = EVENT_STATE(CCTO:000917, t0)" xsd:string ! schema ''Delusions''(time_t t0) = EVENT_STATE(''Delusions'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000918 name: Euphoria def: "An exaggerated feeling of well-being which is disproportionate to events and stimuli. It may result from psychological causes, organic brain syndromes, or toxic states OR A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli." [NCIT:C34598, NCI:CTCAE] synonym: "Euphoria adverse event" EXACT [NCIT:C55453] xref: UMLS:C0235146 xref: UMLS:C1963107 xref: NCI:CTCAE:10015533 xref: NCIT:C34598 xref: NCIT:C55453 property_value: ESCORT_rule "CCTO:000918 implies CCTO:000049" xsd:string ! ESCORT_rule ''Euphoria'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000918 implies CCTO:001105" xsd:string ! ESCORT_rule ''Euphoria'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000918(time_t t0) = EVENT_STATE(CCTO:000918, t0)" xsd:string ! schema ''Euphoria''(time_t t0) = EVENT_STATE(''Euphoria'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000919 name: Hallucinations def: "A false sensory perception in the absence of an external stimulus, as distinct from an illusion which is a misperception of an external stimulus OR A disorder characterized by a false sensory perception in the absence of an external stimulus." [NCIT:C37961, NCI:CTCAE] synonym: "Hallucination" EXACT [NCIT:C37961] xref: UMLS:C0018524 xref: NCI:CTCAE:10019077 xref: NCIT:C37961 property_value: ESCORT_rule "CCTO:000919 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hallucinations'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000919 implies CCTO:001105" xsd:string ! ESCORT_rule ''Hallucinations'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000919(time_t t0) = EVENT_STATE(CCTO:000919, t0)" xsd:string ! schema ''Hallucinations''(time_t t0) = EVENT_STATE(''Hallucinations'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000920 name: Insomnia def: "A disorder characterized by difficulty in falling asleep and/or remaining asleep OR A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep OR A question about an individual's sleep quality." [NCI:CTCAE, NCIT:C28286, NCIT:C121705] synonym: "Insomnia adverse event" EXACT [NCIT:C55333] synonym: "Insomnia distress" EXACT [NCIT:C121705] synonym: "My sleep quality was" EXACT [NCIT:C121705] synonym: "Sleep quality" EXACT [NCIT:C121705] xref: UMLS:C1963237 xref: UMLS:C0917801 xref: UMLS:C0424563 xref: NCI:CTCAE:10022437 xref: NCIT:C121705 xref: NCIT:C28286 xref: NCIT:C55333 property_value: ESCORT_rule "CCTO:000920 implies CCTO:000049" xsd:string ! ESCORT_rule ''Insomnia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000920 implies CCTO:001105" xsd:string ! ESCORT_rule ''Insomnia'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000920(time_t t0) = EVENT_STATE(CCTO:000920, t0)" xsd:string ! schema ''Insomnia''(time_t t0) = EVENT_STATE(''Insomnia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000921 name: Libido decreased def: "Decreased sexual desire OR A disorder characterized by a decrease in sexual desire." [NCIT:C78432, NCI:CTCAE] synonym: "Decreased libido" EXACT [NCIT:C78432] xref: UMLS:C0011124 xref: NCI:CTCAE:10024419 xref: NCIT:C78432 property_value: ESCORT_rule "CCTO:000921 implies CCTO:000049" xsd:string ! ESCORT_rule ''Libido decreased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000921 implies CCTO:001105" xsd:string ! ESCORT_rule ''Libido decreased'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000921(time_t t0) = EVENT_STATE(CCTO:000921, t0)" xsd:string ! schema ''Libido decreased''(time_t t0) = EVENT_STATE(''Libido decreased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000922 name: Libido increased def: "A disorder characterized by an increase in sexual desire OR Increased sexual desire." [NCI:CTCAE, NCIT:C78433] synonym: "Increased libido" EXACT [NCIT:C78433] xref: UMLS:C0021177 xref: NCI:CTCAE:10024421 xref: NCIT:C78433 property_value: ESCORT_rule "CCTO:000922 implies CCTO:000049" xsd:string ! ESCORT_rule ''Libido increased'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000922 implies CCTO:001105" xsd:string ! ESCORT_rule ''Libido increased'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000922(time_t t0) = EVENT_STATE(CCTO:000922, t0)" xsd:string ! schema ''Libido increased''(time_t t0) = EVENT_STATE(''Libido increased'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000923 name: Mania def: "Excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganisation of behaviour and elevation of mood OR A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood." [NCIT:C61374, NCI:CTCAE] synonym: "Manic state" EXACT [NCIT:C61374] synonym: "Manic" EXACT [NCIT:C61374] xref: UMLS:C0338831 xref: NCI:CTCAE:10026749 xref: NCIT:C61374 property_value: ESCORT_rule "CCTO:000923 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mania'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000923 implies CCTO:001105" xsd:string ! ESCORT_rule ''Mania'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000923(time_t t0) = EVENT_STATE(CCTO:000923, t0)" xsd:string ! schema ''Mania''(time_t t0) = EVENT_STATE(''Mania'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000924 name: Personality change def: "A noticeable change in a person's behavior and thinking. Causes include depression, drug or alcohol abuse, brain injuries, brain tumors, and Alzheimer's disease OR A disorder characterized by a conspicuous change in a person's behavior and thinking." [NCIT:C78548, NCI:CTCAE] xref: UMLS:C0240735 xref: NCI:CTCAE:10034719 xref: NCIT:C78548 property_value: ESCORT_rule "CCTO:000924 implies CCTO:000049" xsd:string ! ESCORT_rule ''Personality change'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000924 implies CCTO:001105" xsd:string ! ESCORT_rule ''Personality change'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000924(time_t t0) = EVENT_STATE(CCTO:000924, t0)" xsd:string ! schema ''Personality change''(time_t t0) = EVENT_STATE(''Personality change'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000925 name: Psychosis def: "A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor OR A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality." [NCI:CTCAE, NCIT:C78576] xref: UMLS:C0033975 xref: NCI:CTCAE:10037234 xref: NCIT:C78576 property_value: ESCORT_rule "CCTO:000925 implies CCTO:000049" xsd:string ! ESCORT_rule ''Psychosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000925 implies CCTO:001105" xsd:string ! ESCORT_rule ''Psychosis'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000925(time_t t0) = EVENT_STATE(CCTO:000925, t0)" xsd:string ! schema ''Psychosis''(time_t t0) = EVENT_STATE(''Psychosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000926 name: Restlessness def: "A disorder characterized by an inability to rest, relax or be still OR An inability to rest, relax, or be still." [NCI:CTCAE, NCIT:C74533] synonym: "Feeling of Restlessness" EXACT [NCIT:C74533] synonym: "Restless" EXACT [NCIT:C74533] xref: UMLS:C0085631 xref: NCI:CTCAE:10038743 xref: NCIT:C74533 property_value: ESCORT_rule "CCTO:000926 implies CCTO:000049" xsd:string ! ESCORT_rule ''Restlessness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000926 implies CCTO:001105" xsd:string ! ESCORT_rule ''Restlessness'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000926(time_t t0) = EVENT_STATE(CCTO:000926, t0)" xsd:string ! schema ''Restlessness''(time_t t0) = EVENT_STATE(''Restlessness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000927 name: Suicidal ideation def: "Thoughts of taking one's own life OR A disorder characterized by thoughts of taking one's own life." [NCIT:C80102, NCI:CTCAE] xref: UMLS:C0424000 xref: NCI:CTCAE:10042458 xref: NCIT:C80102 property_value: ESCORT_rule "CCTO:000927 implies CCTO:000049" xsd:string ! ESCORT_rule ''Suicidal ideation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000927 implies CCTO:001105" xsd:string ! ESCORT_rule ''Suicidal ideation'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000927(time_t t0) = EVENT_STATE(CCTO:000927, t0)" xsd:string ! schema ''Suicidal ideation''(time_t t0) = EVENT_STATE(''Suicidal ideation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000928 name: Suicide attempt def: "A disorder characterized by self-inflicted harm in an attempt to end one's own life OR Self-inflicted harm in an attempt to end one's own life." [NCI:CTCAE, NCIT:C80111] xref: UMLS:C0038663 xref: UMLS:C1547270 xref: NCI:CTCAE:10042464 xref: NCIT:C80111 property_value: ESCORT_rule "CCTO:000928 implies CCTO:000049" xsd:string ! ESCORT_rule ''Suicide attempt'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000928 implies CCTO:001105" xsd:string ! ESCORT_rule ''Suicide attempt'' implies ''Psychiatric disorders'' property_value: schema "CCTO:000928(time_t t0) = EVENT_STATE(CCTO:000928, t0)" xsd:string ! schema ''Suicide attempt''(time_t t0) = EVENT_STATE(''Suicide attempt'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001105 ! Psychiatric disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000929 name: Acute kidney injury def: "Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria OR A disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction)." [NCIT:C26808, NCI:CTCAE] synonym: "AKI" EXACT [NCIT:C26808] synonym: "ARF" EXACT [NCIT:C26808] synonym: "Acute renal failure" EXACT [NCIT:C26808] xref: UMLS:C0022660 xref: UMLS:C1705280 xref: UMLS:C2609414 xref: UMLS:C0264490 xref: NCI:CTCAE:10069339 xref: NCIT:C26808 xref: NCIT:C80075 property_value: ESCORT_rule "CCTO:000929 implies CCTO:000049" xsd:string ! ESCORT_rule ''Acute kidney injury'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000929 implies CCTO:001125" xsd:string ! ESCORT_rule ''Acute kidney injury'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000929(time_t t0) = EVENT_STATE(CCTO:000929, t0)" xsd:string ! schema ''Acute kidney injury''(time_t t0) = EVENT_STATE(''Acute kidney injury'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000930 name: Bladder perforation def: "A disorder characterized by a rupture in the bladder wall OR A rupture in the bladder wall due to traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78208] synonym: "Bladder perforation adverse event" EXACT [NCIT:C56756] xref: UMLS:C0434133 xref: UMLS:C1963201 xref: NCI:CTCAE:10063575 xref: NCIT:C56756 xref: NCIT:C78208 property_value: ESCORT_rule "CCTO:000930 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bladder perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000930 implies CCTO:001125" xsd:string ! ESCORT_rule ''Bladder perforation'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000930(time_t t0) = EVENT_STATE(CCTO:000930, t0)" xsd:string ! schema ''Bladder perforation''(time_t t0) = EVENT_STATE(''Bladder perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000931 name: Bladder spasm def: "A disorder characterized by a sudden and involuntary contraction of the bladder wall OR A sudden and involuntary contraction of the bladder wall." [NCI:CTCAE, NCIT:C78210] xref: UMLS:C0426390 xref: NCI:CTCAE:10048994 xref: NCIT:C78210 property_value: ESCORT_rule "CCTO:000931 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bladder spasm'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000931 implies CCTO:001125" xsd:string ! ESCORT_rule ''Bladder spasm'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000931(time_t t0) = EVENT_STATE(CCTO:000931, t0)" xsd:string ! schema ''Bladder spasm''(time_t t0) = EVENT_STATE(''Bladder spasm'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000932 name: Chronic kidney disease def: "Impairment of the renal function secondary to chronic kidney damage persisting for three or more months OR A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure." [NCIT:C80078, NCI:CTCAE] synonym: "CKD - Chronic Kidney Disease" EXACT [NCIT:C80078] synonym: "Chronic renal disease" EXACT [NCIT:C80078] synonym: "Chronic renal failure" EXACT [NCIT:C80078] synonym: "Chronic renal insufficiency" EXACT [NCIT:C80078] xref: UMLS:C0022661 xref: UMLS:C1561643 xref: UMLS:C0403447 xref: NCI:CTCAE:10064848 xref: NCIT:C80078 property_value: ESCORT_rule "CCTO:000932 implies CCTO:000049" xsd:string ! ESCORT_rule ''Chronic kidney disease'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000932 implies CCTO:001125" xsd:string ! ESCORT_rule ''Chronic kidney disease'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000932(time_t t0) = EVENT_STATE(CCTO:000932, t0)" xsd:string ! schema ''Chronic kidney disease''(time_t t0) = EVENT_STATE(''Chronic kidney disease'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000933 name: Cystitis noninfective def: "A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract OR An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis." [NCI:CTCAE, NCIT:C78250] synonym: "Non-infectious cystitis" EXACT [NCIT:C78250] xref: UMLS:C0403632 xref: NCI:CTCAE:10063057 xref: NCIT:C78250 property_value: ESCORT_rule "CCTO:000933 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cystitis noninfective'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000933 implies CCTO:001125" xsd:string ! ESCORT_rule ''Cystitis noninfective'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000933(time_t t0) = EVENT_STATE(CCTO:000933, t0)" xsd:string ! schema ''Cystitis noninfective''(time_t t0) = EVENT_STATE(''Cystitis noninfective'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000934 name: Hematuria def: "A disorder characterized by laboratory test results that indicate blood in the urine OR Blood in the urine." [NCI:CTCAE, NCIT:C3090] xref: UMLS:C0018965 xref: NCI:CTCAE:10019450 xref: NCIT:C3090 property_value: ESCORT_rule "CCTO:000934 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hematuria'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000934 implies CCTO:001125" xsd:string ! ESCORT_rule ''Hematuria'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000934(time_t t0) = EVENT_STATE(CCTO:000934, t0)" xsd:string ! schema ''Hematuria''(time_t t0) = EVENT_STATE(''Hematuria'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000935 name: Hemoglobinuria def: "A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine OR A laboratory test result which indicates free hemoglobin in the urine." [NCI:CTCAE, NCIT:C34677] synonym: "Hemoglobinuria adverse event" EXACT [NCIT:C55177] xref: UMLS:C1963124 xref: UMLS:C0019048 xref: NCI:CTCAE:10019489 xref: NCIT:C34677 xref: NCIT:C55177 property_value: ESCORT_rule "CCTO:000935 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hemoglobinuria'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000935 implies CCTO:001125" xsd:string ! ESCORT_rule ''Hemoglobinuria'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000935(time_t t0) = EVENT_STATE(CCTO:000935, t0)" xsd:string ! schema ''Hemoglobinuria''(time_t t0) = EVENT_STATE(''Hemoglobinuria'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000936 name: Proteinuria def: "The presence of abnormal amounts of protein in the urine." [NCIT:C38012] synonym: "Proteinuria adverse event" EXACT [NCIT:C55219] xref: UMLS:C0033687 xref: UMLS:C1962972 xref: NCI:CTCAE:10037032 xref: NCIT:C38012 xref: NCIT:C55219 property_value: ESCORT_rule "CCTO:000936 implies CCTO:000049" xsd:string ! ESCORT_rule ''Proteinuria'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000936 implies CCTO:001125" xsd:string ! ESCORT_rule ''Proteinuria'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000936(time_t t0) = EVENT_STATE(CCTO:000936, t0)" xsd:string ! schema ''Proteinuria''(time_t t0) = EVENT_STATE(''Proteinuria'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000937 name: Renal calculi def: "A disorder characterized by the formation of crystals in the pelvis of the kidney OR The presence of a calculus in the pelvis of the kidney; this is most often composed of mineral salts and proteins OR Crystals in the pelvis of the kidney." [NCI:CTCAE, NCIT:C114667, NCIT:C26807] synonym: "Kidney calculus" EXACT [NCIT:C26807] synonym: "Kidney stone" EXACT [NCIT:C114667] synonym: "Kidney stone" EXACT [NCIT:C26807] synonym: "Nephrolithiasis" EXACT [NCIT:C114667] synonym: "Renal calculus" EXACT [NCIT:C26807] synonym: "Renal stone" EXACT [NCIT:C26807] xref: UMLS:C0022650 xref: UMLS:C0392525 xref: NCI:CTCAE:10038385 xref: NCIT:C114667 xref: NCIT:C26807 property_value: ESCORT_rule "CCTO:000937 implies CCTO:000049" xsd:string ! ESCORT_rule ''Renal calculi'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000937 implies CCTO:001125" xsd:string ! ESCORT_rule ''Renal calculi'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000937(time_t t0) = EVENT_STATE(CCTO:000937, t0)" xsd:string ! schema ''Renal calculi''(time_t t0) = EVENT_STATE(''Renal calculi'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000938 name: Renal colic def: "A disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones OR Paroxysmal and severe flank pain radiating to the inguinal area. It is caused by the passage of a kidney stone through the ureter." [NCI:CTCAE, NCIT:C78593] xref: UMLS:C0152169 xref: NCI:CTCAE:10038419 xref: NCIT:C78593 property_value: ESCORT_rule "CCTO:000938 implies CCTO:000049" xsd:string ! ESCORT_rule ''Renal colic'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000938 implies CCTO:001125" xsd:string ! ESCORT_rule ''Renal colic'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000938(time_t t0) = EVENT_STATE(CCTO:000938, t0)" xsd:string ! schema ''Renal colic''(time_t t0) = EVENT_STATE(''Renal colic'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000939 name: Renal hemorrhage def: "Bleeding originating from the kidney OR A disorder characterized by bleeding from the kidney." [NCIT:C78594, NCI:CTCAE] xref: UMLS:C0392175 xref: NCI:CTCAE:10038463 xref: NCIT:C78594 property_value: ESCORT_rule "CCTO:000939 implies CCTO:000049" xsd:string ! ESCORT_rule ''Renal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000939 implies CCTO:001125" xsd:string ! ESCORT_rule ''Renal hemorrhage'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000939(time_t t0) = EVENT_STATE(CCTO:000939, t0)" xsd:string ! schema ''Renal hemorrhage''(time_t t0) = EVENT_STATE(''Renal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000940 name: Urinary fistula def: "A disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site OR An abnormal communication between any part of the urinary system and another organ or cavity." [NCI:CTCAE, NCIT:C79850] synonym: "Urinary tract fistula" EXACT [NCIT:C79850] xref: UMLS:C0042021 xref: NCI:CTCAE:10065368 xref: NCIT:C79850 property_value: ESCORT_rule "CCTO:000940 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000940 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary fistula'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000940(time_t t0) = EVENT_STATE(CCTO:000940, t0)" xsd:string ! schema ''Urinary fistula''(time_t t0) = EVENT_STATE(''Urinary fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000941 name: Urinary frequency def: "Urination at short intervals; it may result from increased urine formation, decreased bladder capacity, or lower urinary tract irritation OR A disorder characterized by urination at short intervals." [NCIT:C26906, NCI:CTCAE] synonym: "Frequency, urinary" EXACT [NCIT:C26906] xref: UMLS:C0042023 xref: NCI:CTCAE:10046539 xref: NCIT:C26906 property_value: ESCORT_rule "CCTO:000941 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary frequency'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000941 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary frequency'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000941(time_t t0) = EVENT_STATE(CCTO:000941, t0)" xsd:string ! schema ''Urinary frequency''(time_t t0) = EVENT_STATE(''Urinary frequency'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000942 name: Urinary incontinence def: "A disorder characterized by inability to control the flow of urine from the bladder OR Involuntary passage of urine outside the body." [NCI:CTCAE, NCIT:C78497] synonym: "Enuresis" EXACT [NCIT:C78497] xref: UMLS:C0042024 xref: UMLS:C0270327 xref: UMLS:C0014394 xref: NCI:CTCAE:10046543 xref: NCIT:C78497 property_value: ESCORT_rule "CCTO:000942 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary incontinence'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000942 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary incontinence'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000942(time_t t0) = EVENT_STATE(CCTO:000942, t0)" xsd:string ! schema ''Urinary incontinence''(time_t t0) = EVENT_STATE(''Urinary incontinence'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000943 name: Urinary retention def: "A disorder characterized by accumulation of urine within the bladder because of the inability to urinate OR Accumulation of urine within the bladder because of the inability to urinate." [NCI:CTCAE, NCIT:C50790] synonym: "Bladder distention" EXACT [NCIT:C50790] synonym: "Retention, urinary" EXACT [NCIT:C50790] synonym: "Urine retention" EXACT [NCIT:C50790] xref: UMLS:C0080274 xref: UMLS:C0005687 xref: NCI:CTCAE:10046555 xref: NCIT:C50790 property_value: ESCORT_rule "CCTO:000943 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary retention'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000943 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary retention'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000943(time_t t0) = EVENT_STATE(CCTO:000943, t0)" xsd:string ! schema ''Urinary retention''(time_t t0) = EVENT_STATE(''Urinary retention'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000944 name: Urinary tract obstruction def: "A disorder characterized by blockage of the normal flow of contents of the urinary tract OR Blockage of the normal flow of contents of the urinary tract." [NCI:CTCAE, NCIT:C79805] xref: UMLS:C0178879 xref: NCI:CTCAE:10061574 xref: NCIT:C79805 property_value: ESCORT_rule "CCTO:000944 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary tract obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000944 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary tract obstruction'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000944(time_t t0) = EVENT_STATE(CCTO:000944, t0)" xsd:string ! schema ''Urinary tract obstruction''(time_t t0) = EVENT_STATE(''Urinary tract obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000945 name: Urinary tract pain def: "Painful sensation in any part of the urinary tract OR A disorder characterized by a sensation of marked discomfort in the urinary tract." [NCIT:C83493, NCI:CTCAE] xref: UMLS:C0423701 xref: NCI:CTCAE:10062225 xref: NCIT:C83493 property_value: ESCORT_rule "CCTO:000945 implies CCTO:000107" xsd:string ! ESCORT_rule ''Urinary tract pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000945 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary tract pain'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000945(time_t t0) = EVENT_STATE(CCTO:000945, t0)" xsd:string ! schema ''Urinary tract pain''(time_t t0) = EVENT_STATE(''Urinary tract pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000946 name: Urinary urgency def: "An acute and compelling urge to urinate OR A disorder characterized by a sudden compelling urge to urinate." [NCIT:C50792, NCI:CTCAE] synonym: "Micturation urgency" EXACT [NCIT:C50792] xref: UMLS:C0085606 xref: NCI:CTCAE:10046593 xref: NCIT:C50792 property_value: ESCORT_rule "CCTO:000946 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urinary urgency'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000946 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urinary urgency'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000946(time_t t0) = EVENT_STATE(CCTO:000946, t0)" xsd:string ! schema ''Urinary urgency''(time_t t0) = EVENT_STATE(''Urinary urgency'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000947 name: Urine discoloration def: "A disorder characterized by a change in the color of the urine OR Change in the color of the urine. Causes include medications, vitamins, urinary tract infection, liver disease, hemolysis, and kidney cancer." [NCI:CTCAE, NCIT:C78678] xref: UMLS:C0522153 xref: NCI:CTCAE:10046628 xref: NCIT:C78678 property_value: ESCORT_rule "CCTO:000947 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urine discoloration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000947 implies CCTO:001125" xsd:string ! ESCORT_rule ''Urine discoloration'' implies ''Renal and urinary disorders'' property_value: schema "CCTO:000947(time_t t0) = EVENT_STATE(CCTO:000947, t0)" xsd:string ! schema ''Urine discoloration''(time_t t0) = EVENT_STATE(''Urine discoloration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001125 ! Renal and urinary disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000948 name: Azoospermia def: "A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen OR Complete absence of spermatozoa in the semen." [NCI:CTCAE, NCIT:C80076] synonym: "Aspermia" EXACT [NCIT:C80076] xref: UMLS:C1704202 xref: UMLS:C0004509 xref: NCI:CTCAE:10003883 xref: NCIT:C80076 property_value: ESCORT_rule "CCTO:000948 implies CCTO:000049" xsd:string ! ESCORT_rule ''Azoospermia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000948 implies CCTO:001126" xsd:string ! ESCORT_rule ''Azoospermia'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000948(time_t t0) = EVENT_STATE(CCTO:000948, t0)" xsd:string ! schema ''Azoospermia''(time_t t0) = EVENT_STATE(''Azoospermia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000949 name: Breast atrophy def: "Involution of the breast parenchyma OR A disorder characterized by underdevelopment of the breast." [NCIT:C83494, NCI:CTCAE] xref: UMLS:C0151511 xref: NCI:CTCAE:10006179 xref: NCIT:C83494 property_value: ESCORT_rule "CCTO:000949 implies CCTO:000049" xsd:string ! ESCORT_rule ''Breast atrophy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000949 implies CCTO:001126" xsd:string ! ESCORT_rule ''Breast atrophy'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000949(time_t t0) = EVENT_STATE(CCTO:000949, t0)" xsd:string ! schema ''Breast atrophy''(time_t t0) = EVENT_STATE(''Breast atrophy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000950 name: Breast pain def: "A disorder characterized by marked discomfort sensation in the breast region OR Painful sensation in the breast region." [NCI:CTCAE, NCIT:C78223] synonym: "Breast pain adverse event" EXACT [NCIT:C56025] xref: UMLS:C0024902 xref: UMLS:C1963166 xref: NCI:CTCAE:10006298 xref: NCIT:C56025 xref: NCIT:C78223 property_value: ESCORT_rule "CCTO:000950 implies CCTO:000107" xsd:string ! ESCORT_rule ''Breast pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000950 implies CCTO:001126" xsd:string ! ESCORT_rule ''Breast pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000950(time_t t0) = EVENT_STATE(CCTO:000950, t0)" xsd:string ! schema ''Breast pain''(time_t t0) = EVENT_STATE(''Breast pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000951 name: Dysmenorrhea def: "Abnormally painful abdominal cramps during menstruation OR A disorder characterized by abnormally painful abdominal cramps during menses." [NCIT:C34559, NCI:CTCAE] xref: UMLS:C0013390 xref: NCI:CTCAE:10013934 xref: NCIT:C34559 property_value: ESCORT_rule "CCTO:000951 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dysmenorrhea'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000951 implies CCTO:001126" xsd:string ! ESCORT_rule ''Dysmenorrhea'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000951(time_t t0) = EVENT_STATE(CCTO:000951, t0)" xsd:string ! schema ''Dysmenorrhea''(time_t t0) = EVENT_STATE(''Dysmenorrhea'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000952 name: Dyspareunia def: "A disorder characterized by painful or difficult coitus OR Painful or difficult coitus." [NCI:CTCAE, NCIT:C2997] xref: UMLS:C0013394 xref: UMLS:C1384606 xref: NCI:CTCAE:10013941 xref: NCIT:C2997 property_value: ESCORT_rule "CCTO:000952 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dyspareunia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000952 implies CCTO:001126" xsd:string ! ESCORT_rule ''Dyspareunia'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000952(time_t t0) = EVENT_STATE(CCTO:000952, t0)" xsd:string ! schema ''Dyspareunia''(time_t t0) = EVENT_STATE(''Dyspareunia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000953 name: Ejaculation disorder def: "A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation OR A disorder referring to problems related to ejaculation. This category includes premature, delayed, retrograde, and painful ejaculation." [NCI:CTCAE, NCIT:C78264] synonym: "Ejaculation dysfunction" EXACT [NCIT:C78264] synonym: "Ejaculatory dysfunction" EXACT [NCIT:C78264] xref: UMLS:C0235969 xref: UMLS:C1558165 xref: NCI:CTCAE:10014326 xref: NCIT:C78264 property_value: ESCORT_rule "CCTO:000953 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ejaculation disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000953 implies CCTO:001126" xsd:string ! ESCORT_rule ''Ejaculation disorder'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000953(time_t t0) = EVENT_STATE(CCTO:000953, t0)" xsd:string ! schema ''Ejaculation disorder''(time_t t0) = EVENT_STATE(''Ejaculation disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000954 name: Erectile dysfunction def: "A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity OR A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity OR Persistent or recurrent inability to achieve or to maintain an erection during sexual activity." [NCIT:C34801, NCI:CTCAE, NCIT:C3133] synonym: "Erectile dysfunction adverse event" EXACT [NCIT:C55615] synonym: "Impotence" EXACT [NCIT:C3133] synonym: "Impotent" EXACT [NCIT:C3133] synonym: "Male erectile disorder" EXACT [NCIT:C34801] xref: UMLS:C0242350 xref: UMLS:C1961100 xref: NCI:CTCAE:10061461 xref: NCIT:C3133 xref: NCIT:C34801 xref: NCIT:C55615 property_value: ESCORT_rule "CCTO:000954 implies CCTO:000049" xsd:string ! ESCORT_rule ''Erectile dysfunction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000954 implies CCTO:001126" xsd:string ! ESCORT_rule ''Erectile dysfunction'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000954(time_t t0) = EVENT_STATE(CCTO:000954, t0)" xsd:string ! schema ''Erectile dysfunction''(time_t t0) = EVENT_STATE(''Erectile dysfunction'', t0) is_a: CCTO:000039 ! Measure of sexual function is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000955 name: Fallopian tube obstruction def: "A disorder characterized by blockage of the normal flow of the contents in the fallopian tube OR Blockage of the normal flow of the contents in the fallopian tube." [NCI:CTCAE, NCIT:C78293] synonym: "Fallopian tube obstruction adverse event" EXACT [NCIT:C57059] xref: UMLS:C0041274 xref: UMLS:C1963253 xref: NCI:CTCAE:10065789 xref: NCIT:C57059 xref: NCIT:C78293 property_value: ESCORT_rule "CCTO:000955 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fallopian tube obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000955 implies CCTO:001126" xsd:string ! ESCORT_rule ''Fallopian tube obstruction'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000955(time_t t0) = EVENT_STATE(CCTO:000955, t0)" xsd:string ! schema ''Fallopian tube obstruction''(time_t t0) = EVENT_STATE(''Fallopian tube obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000956 name: Fallopian tube stenosis def: "A disorder characterized by a narrowing of the fallopian tube lumen OR Narrowing of the lumen of the fallopian tube." [NCI:CTCAE, NCIT:C78295] xref: UMLS:C0459524 xref: NCI:CTCAE:10065791 xref: NCIT:C78295 property_value: ESCORT_rule "CCTO:000956 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fallopian tube stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000956 implies CCTO:001126" xsd:string ! ESCORT_rule ''Fallopian tube stenosis'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000956(time_t t0) = EVENT_STATE(CCTO:000956, t0)" xsd:string ! schema ''Fallopian tube stenosis''(time_t t0) = EVENT_STATE(''Fallopian tube stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000957 name: Female genital tract fistula def: "A disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site OR An abnormal communication between a female reproductive system organ and another organ or cavity." [NCI:CTCAE, NCIT:C78298] xref: UMLS:C0269131 xref: NCI:CTCAE:10061149 xref: NCIT:C78298 property_value: ESCORT_rule "CCTO:000957 implies CCTO:000049" xsd:string ! ESCORT_rule ''Female genital tract fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000957 implies CCTO:001126" xsd:string ! ESCORT_rule ''Female genital tract fistula'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000957(time_t t0) = EVENT_STATE(CCTO:000957, t0)" xsd:string ! schema ''Female genital tract fistula''(time_t t0) = EVENT_STATE(''Female genital tract fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000958 name: Feminization acquired def: "The development of secondary female sex characteristics in males due to extrinsic factors OR A disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors." [NCIT:C78299, NCI:CTCAE] synonym: "Acquired feminization" EXACT [NCIT:C78299] xref: UMLS:C0877195 xref: NCI:CTCAE:10054382 xref: NCIT:C78299 property_value: ESCORT_rule "CCTO:000958 implies CCTO:000049" xsd:string ! ESCORT_rule ''Feminization acquired'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000958 implies CCTO:001126" xsd:string ! ESCORT_rule ''Feminization acquired'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000958(time_t t0) = EVENT_STATE(CCTO:000958, t0)" xsd:string ! schema ''Feminization acquired''(time_t t0) = EVENT_STATE(''Feminization acquired'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000959 name: Genital edema def: "A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals OR Swelling due to an excessive accumulation of fluid in the genitals." [NCI:CTCAE, NCIT:C78324] xref: UMLS:C0151604 xref: NCI:CTCAE:10018146 xref: NCIT:C78324 property_value: ESCORT_rule "CCTO:000959 implies CCTO:000226" xsd:string ! ESCORT_rule ''Genital edema'' implies ''Edema'' property_value: ESCORT_rule "CCTO:000959 implies CCTO:001126" xsd:string ! ESCORT_rule ''Genital edema'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000959(time_t t0) = EVENT_STATE(CCTO:000959, t0)" xsd:string ! schema ''Genital edema''(time_t t0) = EVENT_STATE(''Genital edema'', t0) is_a: CCTO:000226 ! Edema is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000960 name: Gynecomastia def: "A disorder characterized by excessive development of the breasts in males OR Development of breast tissue in males." [NCI:CTCAE, NCIT:C3073] synonym: "Gynecomastia adverse event" EXACT [NCIT:C55619] xref: UMLS:C1963120 xref: UMLS:C0018418 xref: NCI:CTCAE:10018801 xref: NCIT:C3073 xref: NCIT:C55619 property_value: ESCORT_rule "CCTO:000960 implies CCTO:000049" xsd:string ! ESCORT_rule ''Gynecomastia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000960 implies CCTO:001126" xsd:string ! ESCORT_rule ''Gynecomastia'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000960(time_t t0) = EVENT_STATE(CCTO:000960, t0)" xsd:string ! schema ''Gynecomastia''(time_t t0) = EVENT_STATE(''Gynecomastia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000961 name: Hematosalpinx def: "The presence of blood in a fallopian tube OR A disorder characterized by the presence of blood in a fallopian tube." [NCIT:C78332, NCI:CTCAE] xref: UMLS:C0018962 xref: NCI:CTCAE:10060602 xref: NCIT:C78332 property_value: ESCORT_rule "CCTO:000961 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hematosalpinx'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000961 implies CCTO:001126" xsd:string ! ESCORT_rule ''Hematosalpinx'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000961(time_t t0) = EVENT_STATE(CCTO:000961, t0)" xsd:string ! schema ''Hematosalpinx''(time_t t0) = EVENT_STATE(''Hematosalpinx'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000962 name: Irregular menstruation def: "Deviations from the normal process; e.g. delayed, difficult, profuse, scanty, unusual bleeding, etc OR A disorder characterized by irregular cycle or duration of menses." [NCIT:C35219, NCI:CTCAE] synonym: "Irregularities, menstrual" EXACT [NCIT:C35219] synonym: "Menstrual irregularities" EXACT [NCIT:C35219] xref: UMLS:C0156404 xref: NCI:CTCAE:10022992 xref: NCIT:C35219 property_value: ESCORT_rule "CCTO:000962 implies CCTO:000049" xsd:string ! ESCORT_rule ''Irregular menstruation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000962 implies CCTO:001126" xsd:string ! ESCORT_rule ''Irregular menstruation'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000962(time_t t0) = EVENT_STATE(CCTO:000962, t0)" xsd:string ! schema ''Irregular menstruation''(time_t t0) = EVENT_STATE(''Irregular menstruation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000963 name: Lactation disorder def: "A disorder not necessarily related to pregnancy that is observed in females and males. It is characterized by disturbances of milk secretion. Causes include damage to the breast parenchyma due to inflammation, medications, pituitary tumors, and hypothyroidism OR A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males." [NCIT:C79606, NCI:CTCAE] xref: UMLS:C0022927 xref: NCI:CTCAE:10061261 xref: NCIT:C79606 property_value: ESCORT_rule "CCTO:000963 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lactation disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000963 implies CCTO:001126" xsd:string ! ESCORT_rule ''Lactation disorder'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000963(time_t t0) = EVENT_STATE(CCTO:000963, t0)" xsd:string ! schema ''Lactation disorder''(time_t t0) = EVENT_STATE(''Lactation disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000964 name: Menorrhagia def: "Heavy bleeding during regular menstruation OR A disorder characterized by abnormally heavy vaginal bleeding during menses." [NCIT:C26829, NCI:CTCAE] xref: UMLS:C0025323 xref: NCI:CTCAE:10027313 xref: NCIT:C26829 property_value: ESCORT_rule "CCTO:000964 implies CCTO:000049" xsd:string ! ESCORT_rule ''Menorrhagia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000964 implies CCTO:001126" xsd:string ! ESCORT_rule ''Menorrhagia'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000964(time_t t0) = EVENT_STATE(CCTO:000964, t0)" xsd:string ! schema ''Menorrhagia''(time_t t0) = EVENT_STATE(''Menorrhagia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000965 name: Nipple deformity def: "A disorder characterized by a malformation of the nipple OR A congenital or acquired deformity of the nipple." [NCI:CTCAE, NCIT:C78503] xref: UMLS:C0342102 xref: NCI:CTCAE:10065823 xref: NCIT:C78503 property_value: ESCORT_rule "CCTO:000965 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nipple deformity'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000965 implies CCTO:001126" xsd:string ! ESCORT_rule ''Nipple deformity'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000965(time_t t0) = EVENT_STATE(CCTO:000965, t0)" xsd:string ! schema ''Nipple deformity''(time_t t0) = EVENT_STATE(''Nipple deformity'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000966 name: Oligospermia def: "Decreased number of spermatozoa in the semen OR A disorder characterized by a decrease in the number of spermatozoa in the semen." [NCIT:C34860, NCI:CTCAE] synonym: "Low sperm count" EXACT [NCIT:C34860] xref: UMLS:C0028960 xref: NCI:CTCAE:10030300 xref: NCIT:C34860 property_value: ESCORT_rule "CCTO:000966 implies CCTO:000049" xsd:string ! ESCORT_rule ''Oligospermia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000966 implies CCTO:001126" xsd:string ! ESCORT_rule ''Oligospermia'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000966(time_t t0) = EVENT_STATE(CCTO:000966, t0)" xsd:string ! schema ''Oligospermia''(time_t t0) = EVENT_STATE(''Oligospermia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000967 name: Ovarian hemorrhage def: "A disorder characterized by bleeding from the ovary OR Bleeding originating from the ovary." [NCI:CTCAE, NCIT:C78511] xref: UMLS:C1696704 xref: NCI:CTCAE:10065763 xref: NCIT:C78511 property_value: ESCORT_rule "CCTO:000967 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ovarian hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000967 implies CCTO:001126" xsd:string ! ESCORT_rule ''Ovarian hemorrhage'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000967(time_t t0) = EVENT_STATE(CCTO:000967, t0)" xsd:string ! schema ''Ovarian hemorrhage''(time_t t0) = EVENT_STATE(''Ovarian hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000968 name: Ovarian rupture def: "Tearing or disruption of the ovarian tissue OR A disorder characterized by tearing or disruption of the ovarian tissue." [NCIT:C78513, NCI:CTCAE] xref: UMLS:C0269164 xref: NCI:CTCAE:10033279 xref: NCIT:C78513 property_value: ESCORT_rule "CCTO:000968 implies CCTO:000049" xsd:string ! ESCORT_rule ''Ovarian rupture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000968 implies CCTO:001126" xsd:string ! ESCORT_rule ''Ovarian rupture'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000968(time_t t0) = EVENT_STATE(CCTO:000968, t0)" xsd:string ! schema ''Ovarian rupture''(time_t t0) = EVENT_STATE(''Ovarian rupture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000969 name: Ovulation pain def: "Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle OR A disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle OR Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle." [NCIT:C78514, NCI:CTCAE, NCIT:C79700] synonym: "Ovulatory pain" EXACT [NCIT:C78514] xref: UMLS:C0152149 xref: UMLS:C1963168 xref: NCI:CTCAE:10033314 xref: NCIT:C78514 xref: NCIT:C79700 property_value: ESCORT_rule "CCTO:000969 implies CCTO:000107" xsd:string ! ESCORT_rule ''Ovulation pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000969 implies CCTO:001126" xsd:string ! ESCORT_rule ''Ovulation pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000969(time_t t0) = EVENT_STATE(CCTO:000969, t0)" xsd:string ! schema ''Ovulation pain''(time_t t0) = EVENT_STATE(''Ovulation pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000970 name: Pelvic floor muscle weakness def: "A disorder characterized by a reduction in the strength of the muscles of the pelvic floor OR A reduction in the strength of the muscles of the pelvic floor." [NCI:CTCAE, NCIT:C78524] xref: UMLS:C1535916 xref: NCI:CTCAE:10064026 xref: NCIT:C78524 property_value: ESCORT_rule "CCTO:000970 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pelvic floor muscle weakness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000970 implies CCTO:001126" xsd:string ! ESCORT_rule ''Pelvic floor muscle weakness'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000970(time_t t0) = EVENT_STATE(CCTO:000970, t0)" xsd:string ! schema ''Pelvic floor muscle weakness''(time_t t0) = EVENT_STATE(''Pelvic floor muscle weakness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000971 name: Pelvic pain def: "Painful sensation in the pelvis OR A disorder characterized by marked discomfort sensation in the pelvis." [NCIT:C40122, NCI:CTCAE] xref: UMLS:C0030794 xref: UMLS:C0850758 xref: NCI:CTCAE:10034263 xref: NCIT:C40122 property_value: ESCORT_rule "CCTO:000971 implies CCTO:000107" xsd:string ! ESCORT_rule ''Pelvic pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000971 implies CCTO:001126" xsd:string ! ESCORT_rule ''Pelvic pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000971(time_t t0) = EVENT_STATE(CCTO:000971, t0)" xsd:string ! schema ''Pelvic pain''(time_t t0) = EVENT_STATE(''Pelvic pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000972 name: Penile pain def: "A disorder characterized by marked discomfort sensation in the penis OR Painful sensation in the penis." [NCI:CTCAE, NCIT:C78527] xref: UMLS:C0497481 xref: NCI:CTCAE:10034310 xref: NCIT:C78527 property_value: ESCORT_rule "CCTO:000972 implies CCTO:000107" xsd:string ! ESCORT_rule ''Penile pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000972 implies CCTO:001126" xsd:string ! ESCORT_rule ''Penile pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000972(time_t t0) = EVENT_STATE(CCTO:000972, t0)" xsd:string ! schema ''Penile pain''(time_t t0) = EVENT_STATE(''Penile pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000973 name: Perineal pain def: "A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus OR Painful sensation in the perineal area." [NCI:CTCAE, NCIT:C78529] xref: UMLS:C0240717 xref: NCI:CTCAE:10061339 xref: NCIT:C78529 property_value: ESCORT_rule "CCTO:000973 implies CCTO:000107" xsd:string ! ESCORT_rule ''Perineal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000973 implies CCTO:001126" xsd:string ! ESCORT_rule ''Perineal pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000973(time_t t0) = EVENT_STATE(CCTO:000973, t0)" xsd:string ! schema ''Perineal pain''(time_t t0) = EVENT_STATE(''Perineal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000974 name: Premature menopause def: "A disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive OR Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive." [NCI:CTCAE, NCIT:C80099] synonym: "POF" EXACT [NCIT:C80099] synonym: "Premature ovarian failure" EXACT [NCIT:C80099] synonym: "early menopause" EXACT [NCIT:C80099] xref: UMLS:C0025322 xref: UMLS:C0085215 xref: NCI:CTCAE:10036601 xref: NCIT:C80099 property_value: ESCORT_rule "CCTO:000974 implies CCTO:000049" xsd:string ! ESCORT_rule ''Premature menopause'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000974 implies CCTO:001126" xsd:string ! ESCORT_rule ''Premature menopause'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000974(time_t t0) = EVENT_STATE(CCTO:000974, t0)" xsd:string ! schema ''Premature menopause''(time_t t0) = EVENT_STATE(''Premature menopause'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000975 name: Prostatic hemorrhage def: "Bleeding originating from the prostate gland OR A disorder characterized by bleeding from the prostate gland." [NCIT:C78572, NCI:CTCAE] xref: UMLS:C0268891 xref: NCI:CTCAE:10055325 xref: NCIT:C78572 property_value: ESCORT_rule "CCTO:000975 implies CCTO:000049" xsd:string ! ESCORT_rule ''Prostatic hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000975 implies CCTO:001126" xsd:string ! ESCORT_rule ''Prostatic hemorrhage'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000975(time_t t0) = EVENT_STATE(CCTO:000975, t0)" xsd:string ! schema ''Prostatic hemorrhage''(time_t t0) = EVENT_STATE(''Prostatic hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000976 name: Prostatic obstruction def: "A disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder) OR Squeezing of the urethra secondary to enlargement of the prostate gland, resulting in voiding symptoms (straining to void, slow urine stream, and incomplete emptying of the bladder)." [NCI:CTCAE, NCIT:C78573] xref: UMLS:C0268889 xref: NCI:CTCAE:10055026 xref: NCIT:C78573 property_value: ESCORT_rule "CCTO:000976 implies CCTO:000049" xsd:string ! ESCORT_rule ''Prostatic obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000976 implies CCTO:001126" xsd:string ! ESCORT_rule ''Prostatic obstruction'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000976(time_t t0) = EVENT_STATE(CCTO:000976, t0)" xsd:string ! schema ''Prostatic obstruction''(time_t t0) = EVENT_STATE(''Prostatic obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000977 name: Prostatic pain def: "A disorder characterized by a sensation of marked discomfort in the prostate gland OR Pain in the prostate gland." [NCI:CTCAE, NCIT:C78574] xref: UMLS:C0240812 xref: NCI:CTCAE:10036968 xref: NCIT:C78574 property_value: ESCORT_rule "CCTO:000977 implies CCTO:000107" xsd:string ! ESCORT_rule ''Prostatic pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000977 implies CCTO:001126" xsd:string ! ESCORT_rule ''Prostatic pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000977(time_t t0) = EVENT_STATE(CCTO:000977, t0)" xsd:string ! schema ''Prostatic pain''(time_t t0) = EVENT_STATE(''Prostatic pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000978 name: Scrotal pain def: "Painful sensation in the scrotal area OR A disorder characterized by marked discomfort sensation in the scrotal area." [NCIT:C78607, NCI:CTCAE] xref: UMLS:C0236078 xref: NCI:CTCAE:10039757 xref: NCIT:C78607 property_value: ESCORT_rule "CCTO:000978 implies CCTO:000107" xsd:string ! ESCORT_rule ''Scrotal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000978 implies CCTO:001126" xsd:string ! ESCORT_rule ''Scrotal pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000978(time_t t0) = EVENT_STATE(CCTO:000978, t0)" xsd:string ! schema ''Scrotal pain''(time_t t0) = EVENT_STATE(''Scrotal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000979 name: Spermatic cord hemorrhage def: "Bleeding originating from the spermatic cord OR A disorder characterized by bleeding from the spermatic cord." [NCIT:C78623, NCI:CTCAE] synonym: "Spermatic cord hemorrhage adverse event" EXACT [NCIT:C56563] xref: UMLS:C1963130 xref: UMLS:C0268940 xref: NCI:CTCAE:10065762 xref: NCIT:C56563 xref: NCIT:C78623 property_value: ESCORT_rule "CCTO:000979 implies CCTO:000049" xsd:string ! ESCORT_rule ''Spermatic cord hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000979 implies CCTO:001126" xsd:string ! ESCORT_rule ''Spermatic cord hemorrhage'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000979(time_t t0) = EVENT_STATE(CCTO:000979, t0)" xsd:string ! schema ''Spermatic cord hemorrhage''(time_t t0) = EVENT_STATE(''Spermatic cord hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000980 name: Spermatic cord obstruction def: "Blockage of the normal flow of the contents of the spermatic cord OR A disorder characterized by blockage of the normal flow of the contents of the spermatic cord." [NCIT:C78624, NCI:CTCAE] synonym: "Spermatic cord obstruction adverse event" EXACT [NCIT:C57077] xref: UMLS:C1963241 xref: UMLS:C1557933 xref: NCI:CTCAE:10065805 xref: NCIT:C57077 xref: NCIT:C78624 property_value: ESCORT_rule "CCTO:000980 implies CCTO:000049" xsd:string ! ESCORT_rule ''Spermatic cord obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000980 implies CCTO:001126" xsd:string ! ESCORT_rule ''Spermatic cord obstruction'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000980(time_t t0) = EVENT_STATE(CCTO:000980, t0)" xsd:string ! schema ''Spermatic cord obstruction''(time_t t0) = EVENT_STATE(''Spermatic cord obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000981 name: Testicular disorder def: "A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia OR A disorder characterized by involvement of the testis." [NCIT:C26890, NCI:CTCAE] synonym: "Testicular disease" EXACT [NCIT:C26890] xref: UMLS:C0039584 xref: NCI:CTCAE:10043306 xref: NCIT:C26890 property_value: ESCORT_rule "CCTO:000981 implies CCTO:000049" xsd:string ! ESCORT_rule ''Testicular disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000981 implies CCTO:001126" xsd:string ! ESCORT_rule ''Testicular disorder'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000981(time_t t0) = EVENT_STATE(CCTO:000981, t0)" xsd:string ! schema ''Testicular disorder''(time_t t0) = EVENT_STATE(''Testicular disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000982 name: Testicular hemorrhage def: "Bleeding originating from the testis OR A disorder characterized by bleeding from the testis." [NCIT:C78635, NCI:CTCAE] xref: UMLS:C0268969 xref: NCI:CTCAE:10055347 xref: NCIT:C78635 property_value: ESCORT_rule "CCTO:000982 implies CCTO:000049" xsd:string ! ESCORT_rule ''Testicular hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000982 implies CCTO:001126" xsd:string ! ESCORT_rule ''Testicular hemorrhage'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000982(time_t t0) = EVENT_STATE(CCTO:000982, t0)" xsd:string ! schema ''Testicular hemorrhage''(time_t t0) = EVENT_STATE(''Testicular hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000983 name: Testicular pain def: "A painful sensation in the testis OR A disorder characterized by a sensation of marked discomfort in the testis." [NCIT:C78636, NCI:CTCAE] xref: UMLS:C0039591 xref: NCI:CTCAE:10043345 xref: NCIT:C78636 property_value: ESCORT_rule "CCTO:000983 implies CCTO:000107" xsd:string ! ESCORT_rule ''Testicular pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000983 implies CCTO:001126" xsd:string ! ESCORT_rule ''Testicular pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000983(time_t t0) = EVENT_STATE(CCTO:000983, t0)" xsd:string ! schema ''Testicular pain''(time_t t0) = EVENT_STATE(''Testicular pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000984 name: Uterine fistula def: "An abnormal communication between the uterus and another organ OR A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site." [NCIT:C78685, NCI:CTCAE] xref: UMLS:C1696087 xref: NCI:CTCAE:10065811 xref: NCIT:C78685 property_value: ESCORT_rule "CCTO:000984 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uterine fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000984 implies CCTO:001126" xsd:string ! ESCORT_rule ''Uterine fistula'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000984(time_t t0) = EVENT_STATE(CCTO:000984, t0)" xsd:string ! schema ''Uterine fistula''(time_t t0) = EVENT_STATE(''Uterine fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000985 name: Uterine hemorrhage def: "Bleeding originating from the uterus OR A disorder characterized by bleeding from the uterus." [NCIT:C78686, NCI:CTCAE] xref: UMLS:C0042134 xref: NCI:CTCAE:10046789 xref: NCIT:C78686 property_value: ESCORT_rule "CCTO:000985 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uterine hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000985 implies CCTO:001126" xsd:string ! ESCORT_rule ''Uterine hemorrhage'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000985(time_t t0) = EVENT_STATE(CCTO:000985, t0)" xsd:string ! schema ''Uterine hemorrhage''(time_t t0) = EVENT_STATE(''Uterine hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000986 name: Uterine obstruction def: "Blockage of the uterine outlet. Causes include uterine tumors and adhesions OR A disorder characterized by blockage of the uterine outlet." [NCIT:C78693, NCI:CTCAE] xref: UMLS:C1696113 xref: NCI:CTCAE:10065928 xref: NCIT:C78693 property_value: ESCORT_rule "CCTO:000986 implies CCTO:000049" xsd:string ! ESCORT_rule ''Uterine obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000986 implies CCTO:001126" xsd:string ! ESCORT_rule ''Uterine obstruction'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000986(time_t t0) = EVENT_STATE(CCTO:000986, t0)" xsd:string ! schema ''Uterine obstruction''(time_t t0) = EVENT_STATE(''Uterine obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000987 name: Uterine pain def: "A painful sensation in the uterus OR A disorder characterized by a sensation of marked discomfort in the uterus." [NCIT:C78694, NCI:CTCAE] xref: UMLS:C0567085 xref: NCI:CTCAE:10046809 xref: NCIT:C78694 property_value: ESCORT_rule "CCTO:000987 implies CCTO:000107" xsd:string ! ESCORT_rule ''Uterine pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000987 implies CCTO:001126" xsd:string ! ESCORT_rule ''Uterine pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000987(time_t t0) = EVENT_STATE(CCTO:000987, t0)" xsd:string ! schema ''Uterine pain''(time_t t0) = EVENT_STATE(''Uterine pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000988 name: Vaginal discharge def: "A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years OR Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer." [NCI:CTCAE, NCIT:C50795] synonym: "Discharge, vaginal" EXACT [NCIT:C50795] xref: UMLS:C0227791 xref: NCI:CTCAE:10046901 xref: NCIT:C50795 property_value: ESCORT_rule "CCTO:000988 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal discharge'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000988 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal discharge'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000988(time_t t0) = EVENT_STATE(CCTO:000988, t0)" xsd:string ! schema ''Vaginal discharge''(time_t t0) = EVENT_STATE(''Vaginal discharge'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000989 name: Vaginal dryness def: "An uncomfortable feeling of itching and burning in the vaginal opening resulting from inadequate vaginal lubrication. It is commonly seen during and after menopause, childbirth, or stressful conditions. It results in painful intercourse OR A disorder characterized by an uncomfortable feeling of itching and burning in the vagina OR A question about whether an individual is or was bothered by vaginal dryness." [NCIT:C78699, NCI:CTCAE, NCIT:C125650] synonym: "Bothered by Vaginal Dryness" EXACT [NCIT:C125650] synonym: "Vaginal dryness adverse event" EXACT [NCIT:C55645] xref: UMLS:C0241633 xref: UMLS:C1963268 xref: NCI:CTCAE:10046904 xref: NCIT:C125650 xref: NCIT:C55645 xref: NCIT:C78699 property_value: ESCORT_rule "CCTO:000989 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal dryness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000989 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal dryness'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000989(time_t t0) = EVENT_STATE(CCTO:000989, t0)" xsd:string ! schema ''Vaginal dryness''(time_t t0) = EVENT_STATE(''Vaginal dryness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000990 name: Vaginal fistula def: "A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site OR An abnormal communication between the vagina and another organ or cavity." [NCI:CTCAE, NCIT:C79847] synonym: "Fistulous Opening in Vagina" EXACT [NCIT:C79847] xref: UMLS:C0042253 xref: NCI:CTCAE:10065813 xref: NCIT:C79847 property_value: ESCORT_rule "CCTO:000990 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000990 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal fistula'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000990(time_t t0) = EVENT_STATE(CCTO:000990, t0)" xsd:string ! schema ''Vaginal fistula''(time_t t0) = EVENT_STATE(''Vaginal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000991 name: Vaginal hemorrhage def: "A disorder characterized by bleeding from the vagina OR Bleeding originating from the vagina." [NCI:CTCAE, NCIT:C26945] xref: UMLS:C2979982 xref: NCI:CTCAE:10046912 xref: NCIT:C26945 property_value: ESCORT_rule "CCTO:000991 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000991 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal hemorrhage'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000991(time_t t0) = EVENT_STATE(CCTO:000991, t0)" xsd:string ! schema ''Vaginal hemorrhage''(time_t t0) = EVENT_STATE(''Vaginal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000992 name: Vaginal inflammation def: "A disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge OR A non-infectious or infectious inflammatory process affecting the vagina." [NCI:CTCAE, NCIT:C26911] synonym: "Vaginitis" EXACT [NCIT:C26911] xref: UMLS:C0042267 xref: NCI:CTCAE:10046916 xref: NCIT:C26911 property_value: ESCORT_rule "CCTO:000992 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal inflammation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000992 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal inflammation'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000992(time_t t0) = EVENT_STATE(CCTO:000992, t0)" xsd:string ! schema ''Vaginal inflammation''(time_t t0) = EVENT_STATE(''Vaginal inflammation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000993 name: Vaginal obstruction def: "A disorder characterized by blockage of vaginal canal OR Congenital or acquired blockage of the vagina." [NCI:CTCAE, NCIT:C78700] xref: UMLS:C1408443 xref: NCI:CTCAE:10065817 xref: NCIT:C78700 property_value: ESCORT_rule "CCTO:000993 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000993 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal obstruction'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000993(time_t t0) = EVENT_STATE(CCTO:000993, t0)" xsd:string ! schema ''Vaginal obstruction''(time_t t0) = EVENT_STATE(''Vaginal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000994 name: Vaginal pain def: "A disorder characterized by a sensation of marked discomfort in the vagina OR A painful sensation in the vagina." [NCI:CTCAE, NCIT:C78701] xref: UMLS:C0236082 xref: NCI:CTCAE:10046937 xref: NCIT:C78701 property_value: ESCORT_rule "CCTO:000994 implies CCTO:000107" xsd:string ! ESCORT_rule ''Vaginal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:000994 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal pain'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000994(time_t t0) = EVENT_STATE(CCTO:000994, t0)" xsd:string ! schema ''Vaginal pain''(time_t t0) = EVENT_STATE(''Vaginal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000995 name: Vaginal perforation def: "A disorder characterized by a rupture in the vaginal wall OR A rupture in the vaginal wall due to traumatic or pathologic processes." [NCI:CTCAE, NCIT:C78702] xref: UMLS:C1696155 xref: NCI:CTCAE:10065818 xref: NCIT:C78702 property_value: ESCORT_rule "CCTO:000995 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal perforation'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000995 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal perforation'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000995(time_t t0) = EVENT_STATE(CCTO:000995, t0)" xsd:string ! schema ''Vaginal perforation''(time_t t0) = EVENT_STATE(''Vaginal perforation'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000996 name: Vaginal stricture def: "Narrowing of the vaginal lumen OR A disorder characterized by a narrowing of the vaginal canal." [NCIT:C36064, NCI:CTCAE] xref: UMLS:C0269208 xref: NCI:CTCAE:10053496 xref: NCIT:C36064 property_value: ESCORT_rule "CCTO:000996 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginal stricture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000996 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginal stricture'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000996(time_t t0) = EVENT_STATE(CCTO:000996, t0)" xsd:string ! schema ''Vaginal stricture''(time_t t0) = EVENT_STATE(''Vaginal stricture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000997 name: Vaginismus def: "Tightness of the vaginal wall during vaginal penetration including sexual intercourse. It is caused by involuntary spasm of the pelvic floor muscles, and results in painful intercourse or failure to have intercourse. It may due to psychological conditions, trauma in the vaginal area, or vaginal infection OR A disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse." [NCIT:C78703, NCI:CTCAE] xref: UMLS:C0042266 xref: UMLS:C2004487 xref: NCI:CTCAE:10046947 xref: NCIT:C78703 property_value: ESCORT_rule "CCTO:000997 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vaginismus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000997 implies CCTO:001126" xsd:string ! ESCORT_rule ''Vaginismus'' implies ''Reproductive system and breast disorders'' property_value: schema "CCTO:000997(time_t t0) = EVENT_STATE(CCTO:000997, t0)" xsd:string ! schema ''Vaginismus''(time_t t0) = EVENT_STATE(''Vaginismus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001126 ! Reproductive system and breast disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000998 name: Adult respiratory distress syndrome def: "Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition OR A disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery." [NCIT:C3353, NCI:CTCAE] synonym: "ARDS" EXACT [NCIT:C3353] synonym: "Acute respiratory distress syndrome" EXACT [NCIT:C3353] synonym: "Adult RDS" EXACT [NCIT:C3353] synonym: "Adult Respiratory Distress Syndrome, ARDS" EXACT [NCIT:C3353] xref: UMLS:C0035222 xref: NCI:CTCAE:10001409 xref: NCIT:C3353 property_value: ESCORT_rule "CCTO:000998 implies CCTO:000049" xsd:string ! ESCORT_rule ''Adult respiratory distress syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000998 implies CCTO:001127" xsd:string ! ESCORT_rule ''Adult respiratory distress syndrome'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:000998(time_t t0) = EVENT_STATE(CCTO:000998, t0)" xsd:string ! schema ''Adult respiratory distress syndrome''(time_t t0) = EVENT_STATE(''Adult respiratory distress syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:000999 name: Allergic rhinitis def: "Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life OR A disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching." [NCIT:C79532, NCI:CTCAE] xref: UMLS:C2607914 xref: UMLS:C1334103 xref: NCI:CTCAE:10001723 xref: NCIT:C79532 property_value: ESCORT_rule "CCTO:000999 implies CCTO:000049" xsd:string ! ESCORT_rule ''Allergic rhinitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:000999 implies CCTO:001127" xsd:string ! ESCORT_rule ''Allergic rhinitis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:000999(time_t t0) = EVENT_STATE(CCTO:000999, t0)" xsd:string ! schema ''Allergic rhinitis''(time_t t0) = EVENT_STATE(''Allergic rhinitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001000 name: Apnea def: "A disorder characterized by cessation of breathing OR Transient cessation of respiration." [NCI:CTCAE, NCIT:C26698] synonym: "Apnea adverse event" EXACT [NCIT:C55340] synonym: "Arrest, respiratory" EXACT [NCIT:C26698] synonym: "Respiratory arrest" EXACT [NCIT:C26698] xref: UMLS:C0003578 xref: UMLS:C0162297 xref: UMLS:C1963065 xref: NCI:CTCAE:10002972 xref: NCIT:C26698 xref: NCIT:C55340 property_value: ESCORT_rule "CCTO:001000 implies CCTO:000049" xsd:string ! ESCORT_rule ''Apnea'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001000 implies CCTO:001127" xsd:string ! ESCORT_rule ''Apnea'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001000(time_t t0) = EVENT_STATE(CCTO:001000, t0)" xsd:string ! schema ''Apnea''(time_t t0) = EVENT_STATE(''Apnea'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001001 name: Aspiration def: "Procedure using suction, usually with a thin needle and syringe, to remove bodily fluid or tissue OR Accidental inhalation of a foreign material into the lungs OR A disorder characterized by inhalation of solids or liquids into the lungs OR The entry of foreign material past the trachea, and into the lower respiratory tract. Oro-pharyngeal or gastric secretions are the most commonly aspirated materials, and can cause a pneumonitis or pneumonia." [NCIT:C15631, NCIT:C83507, NCI:CTCAE, NCIT:C28245] synonym: "Aspiration adverse event" EXACT [NCIT:C28245] synonym: "Respiratory tract aspiration" EXACT [NCIT:C83507] synonym: "Unintentional material aspiration" EXACT [NCIT:C83507] xref: UMLS:C2827071 xref: UMLS:C1963221 xref: UMLS:C0349707 xref: NCI:CTCAE:10003504 xref: NCIT:C15631 xref: NCIT:C28245 xref: NCIT:C83507 property_value: ESCORT_rule "CCTO:001001 implies CCTO:000049" xsd:string ! ESCORT_rule ''Aspiration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001001 implies CCTO:001127" xsd:string ! ESCORT_rule ''Aspiration'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001001(time_t t0) = EVENT_STATE(CCTO:001001, t0)" xsd:string ! schema ''Aspiration''(time_t t0) = EVENT_STATE(''Aspiration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001002 name: Atelectasis def: "A disorder characterized by the collapse of part or the entire lung OR The collapse of part or the entire lung due to airway obstruction, infection, tumor, or general anesthesia." [NCI:CTCAE, NCIT:C2888] synonym: "Atelectasis adverse event" EXACT [NCIT:C58022] synonym: "UNEXPANDED LUNG" EXACT [NCIT:C2888] xref: UMLS:C0004144 xref: UMLS:C1962948 xref: NCI:CTCAE:10003598 xref: NCIT:C2888 xref: NCIT:C58022 property_value: ESCORT_rule "CCTO:001002 implies CCTO:000049" xsd:string ! ESCORT_rule ''Atelectasis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001002 implies CCTO:001127" xsd:string ! ESCORT_rule ''Atelectasis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001002(time_t t0) = EVENT_STATE(CCTO:001002, t0)" xsd:string ! schema ''Atelectasis''(time_t t0) = EVENT_STATE(''Atelectasis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001003 name: Bronchial fistula def: "A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site OR An abnormal communication between the bronchus and another organ or anatomic site." [NCI:CTCAE, NCIT:C79543] xref: UMLS:C0006262 xref: NCI:CTCAE:10006437 xref: NCIT:C79543 property_value: ESCORT_rule "CCTO:001003 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchial fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001003 implies CCTO:001127" xsd:string ! ESCORT_rule ''Bronchial fistula'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001003(time_t t0) = EVENT_STATE(CCTO:001003, t0)" xsd:string ! schema ''Bronchial fistula''(time_t t0) = EVENT_STATE(''Bronchial fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001004 name: Bronchial obstruction def: "A disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates OR Blockage of a bronchus passage most often by bronchial secretions and exudates." [NCI:CTCAE, NCIT:C78225] xref: UMLS:C0221725 xref: NCI:CTCAE:10006440 xref: NCIT:C78225 property_value: ESCORT_rule "CCTO:001004 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchial obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001004 implies CCTO:001127" xsd:string ! ESCORT_rule ''Bronchial obstruction'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001004(time_t t0) = EVENT_STATE(CCTO:001004, t0)" xsd:string ! schema ''Bronchial obstruction''(time_t t0) = EVENT_STATE(''Bronchial obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001005 name: Bronchial stricture def: "Narrowing of a bronchial tube OR A disorder characterized by a narrowing of the bronchial tube." [NCIT:C78226, NCI:CTCAE] xref: UMLS:C1504507 xref: NCI:CTCAE:10063524 xref: NCIT:C78226 property_value: ESCORT_rule "CCTO:001005 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchial stricture'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001005 implies CCTO:001127" xsd:string ! ESCORT_rule ''Bronchial stricture'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001005(time_t t0) = EVENT_STATE(CCTO:001005, t0)" xsd:string ! schema ''Bronchial stricture''(time_t t0) = EVENT_STATE(''Bronchial stricture'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001006 name: Bronchopleural fistula def: "An abnormal communication between a bronchus and the pleural cavity OR A disorder characterized by an abnormal communication between a bronchus and the pleural cavity." [NCIT:C80694, NCI:CTCAE] xref: UMLS:C0238132 xref: NCI:CTCAE:10053481 xref: NCIT:C80694 property_value: ESCORT_rule "CCTO:001006 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchopleural fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001006 implies CCTO:001127" xsd:string ! ESCORT_rule ''Bronchopleural fistula'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001006(time_t t0) = EVENT_STATE(CCTO:001006, t0)" xsd:string ! schema ''Bronchopleural fistula''(time_t t0) = EVENT_STATE(''Bronchopleural fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001007 name: Bronchopulmonary hemorrhage def: "A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma OR Bleeding from the bronchial wall and/or lung parenchyma." [NCI:CTCAE, NCIT:C78224] synonym: "Bronchial hemorrhage" EXACT [NCIT:C78224] xref: UMLS:C1321133 xref: UMLS:C1560774 xref: NCI:CTCAE:10065746 xref: NCIT:C78224 property_value: ESCORT_rule "CCTO:001007 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchopulmonary hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001007 implies CCTO:001127" xsd:string ! ESCORT_rule ''Bronchopulmonary hemorrhage'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001007(time_t t0) = EVENT_STATE(CCTO:001007, t0)" xsd:string ! schema ''Bronchopulmonary hemorrhage''(time_t t0) = EVENT_STATE(''Bronchopulmonary hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001008 name: Bronchospasm def: "Sudden contraction of the smooth muscles of the bronchial wall OR A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall." [NCIT:C34439, NCI:CTCAE] xref: UMLS:C0006266 xref: NCI:CTCAE:10006482 xref: NCIT:C34439 property_value: ESCORT_rule "CCTO:001008 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bronchospasm'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001008 implies CCTO:001127" xsd:string ! ESCORT_rule ''Bronchospasm'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001008(time_t t0) = EVENT_STATE(CCTO:001008, t0)" xsd:string ! schema ''Bronchospasm''(time_t t0) = EVENT_STATE(''Bronchospasm'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001009 name: Chylothorax def: "A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity OR A milky pleural effusion resulting from accumulation of lymph fluid in the pleural cavity. Causes include malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, sarcoidosis, and congenital causes OR Chylothorax resulting from a known treatment." [NCI:CTCAE, NCIT:C79546, NCIT:C58027] synonym: "Chylothorax adverse event" EXACT [NCIT:C58027] xref: UMLS:C0008733 xref: UMLS:C1962974 xref: NCI:CTCAE:10051228 xref: NCIT:C58027 xref: NCIT:C79546 property_value: ESCORT_rule "CCTO:001009 implies CCTO:000049" xsd:string ! ESCORT_rule ''Chylothorax'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001009 implies CCTO:001127" xsd:string ! ESCORT_rule ''Chylothorax'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001009(time_t t0) = EVENT_STATE(CCTO:001009, t0)" xsd:string ! schema ''Chylothorax''(time_t t0) = EVENT_STATE(''Chylothorax'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001010 name: Cough def: "A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs, and usually accompanied by a distinctive sound OR A question about the frequency of an individual's cough OR A question about the usual severity of an individual's cough OR A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound OR A question about an individual's distress from their cough OR A question about whether an individual is or has been coughing." [NCIT:C37935, NCIT:C124215, NCIT:C125301, NCI:CTCAE, NCIT:C125333, NCIT:C99778] synonym: "Cough adverse event" EXACT [NCIT:C58028] synonym: "Cough distress" EXACT [NCIT:C124215] synonym: "Cough frequency" EXACT [NCIT:C124215] synonym: "Frequency of Coughing" EXACT [NCIT:C124215] synonym: "Have been coughing" EXACT [NCIT:C99778] synonym: "How much distress cough" EXACT [NCIT:C125333] synonym: "How often cough" EXACT [NCIT:C124215] synonym: "I have been coughing" EXACT [NCIT:C99778] synonym: "Usual severity cough" EXACT [NCIT:C125301] xref: UMLS:C3274924 xref: UMLS:C0010200 xref: UMLS:C1961131 xref: NCI:CTCAE:10011224 xref: NCIT:C124215 xref: NCIT:C125301 xref: NCIT:C125333 xref: NCIT:C37935 xref: NCIT:C58028 xref: NCIT:C99778 property_value: ESCORT_rule "CCTO:001010 implies CCTO:000049" xsd:string ! ESCORT_rule ''Cough'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001010 implies CCTO:001127" xsd:string ! ESCORT_rule ''Cough'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001010(time_t t0) = EVENT_STATE(CCTO:001010, t0)" xsd:string ! schema ''Cough''(time_t t0) = EVENT_STATE(''Cough'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001011 name: Dyspnea def: "A disorder characterized by an uncomfortable sensation of difficulty breathing OR An uncomfortable sensation of difficulty breathing. It may present as an acute or chronic sign of an underlying respiratory or heart disorder." [NCI:CTCAE, NCIT:C2998] synonym: "Breathing difficulties" EXACT [NCIT:C2998] synonym: "Difficulty breathing" EXACT [NCIT:C2998] synonym: "Shortness of Breath" EXACT [NCIT:C2998] xref: UMLS:C0013404 xref: UMLS:C2707305 xref: NCI:CTCAE:10013963 xref: NCIT:C2998 property_value: ESCORT_rule "CCTO:001011 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dyspnea'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001011 implies CCTO:001127" xsd:string ! ESCORT_rule ''Dyspnea'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001011(time_t t0) = EVENT_STATE(CCTO:001011, t0)" xsd:string ! schema ''Dyspnea''(time_t t0) = EVENT_STATE(''Dyspnea'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001012 name: Epistaxis def: "A disorder characterized by bleeding from the nose OR Bleeding from the nose." [NCI:CTCAE, NCIT:C26766] synonym: "Nasal hemorrhage" EXACT [NCIT:C26766] synonym: "Nose bleed" EXACT [NCIT:C26766] synonym: "Nosebleed" EXACT [NCIT:C26766] xref: UMLS:C0014591 xref: UMLS:C2724883 xref: NCI:CTCAE:10015090 xref: NCIT:C26766 property_value: ESCORT_rule "CCTO:001012 implies CCTO:000049" xsd:string ! ESCORT_rule ''Epistaxis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001012 implies CCTO:001127" xsd:string ! ESCORT_rule ''Epistaxis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001012(time_t t0) = EVENT_STATE(CCTO:001012, t0)" xsd:string ! schema ''Epistaxis''(time_t t0) = EVENT_STATE(''Epistaxis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001013 name: Hiccups def: "A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm OR An involuntary contraction of the diaphragm against closed vocal cords, producing the ''hic'' sound." [NCI:CTCAE, NCIT:C37966] synonym: "Hiccough" EXACT [NCIT:C37966] synonym: "Hiccup" EXACT [NCIT:C37966] synonym: "Singultus" EXACT [NCIT:C37966] xref: UMLS:C0019521 xref: NCI:CTCAE:10020039 xref: NCIT:C37966 property_value: ESCORT_rule "CCTO:001013 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hiccups'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001013 implies CCTO:001127" xsd:string ! ESCORT_rule ''Hiccups'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001013(time_t t0) = EVENT_STATE(CCTO:001013, t0)" xsd:string ! schema ''Hiccups''(time_t t0) = EVENT_STATE(''Hiccups'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001014 name: Hoarseness def: "A disorder characterized by harsh and raspy voice arising from or spreading to the larynx OR Harsh and raspy voice secondary to laryngeal infection, voice overuse, irritants inhalation, vocal cord paralysis, vocal cord polyps, and malignant neoplasms arising from or spreading to the larynx." [NCI:CTCAE, NCIT:C47813] synonym: "Dysphonia" EXACT [NCIT:C47813] xref: UMLS:C1527344 xref: UMLS:C0019825 xref: NCI:CTCAE:10020201 xref: NCIT:C47813 property_value: ESCORT_rule "CCTO:001014 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hoarseness'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001014 implies CCTO:001127" xsd:string ! ESCORT_rule ''Hoarseness'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001014(time_t t0) = EVENT_STATE(CCTO:001014, t0)" xsd:string ! schema ''Hoarseness''(time_t t0) = EVENT_STATE(''Hoarseness'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001015 name: Hypoxia def: "A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma) OR A disorder characterized by a decrease in the level of oxygen in the body." [NCIT:C3890, NCI:CTCAE] synonym: "Hypoxia adverse event" EXACT [NCIT:C58188] synonym: "Hypoxic" EXACT [NCIT:C3890] xref: UMLS:C0242184 xref: UMLS:C1963140 xref: NCI:CTCAE:10021143 xref: NCIT:C3890 xref: NCIT:C58188 property_value: ESCORT_rule "CCTO:001015 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypoxia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001015 implies CCTO:001127" xsd:string ! ESCORT_rule ''Hypoxia'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001015(time_t t0) = EVENT_STATE(CCTO:001015, t0)" xsd:string ! schema ''Hypoxia''(time_t t0) = EVENT_STATE(''Hypoxia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001016 name: Laryngeal edema def: "Swelling due to an excessive accumulation of fluid in the larynx OR A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx." [NCIT:C79607, NCI:CTCAE] xref: UMLS:C0023052 xref: NCI:CTCAE:10023838 xref: NCIT:C79607 property_value: ESCORT_rule "CCTO:001016 implies CCTO:000226" xsd:string ! ESCORT_rule ''Laryngeal edema'' implies ''Edema'' property_value: ESCORT_rule "CCTO:001016 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngeal edema'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001016(time_t t0) = EVENT_STATE(CCTO:001016, t0)" xsd:string ! schema ''Laryngeal edema''(time_t t0) = EVENT_STATE(''Laryngeal edema'', t0) is_a: CCTO:000226 ! Edema is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001017 name: Laryngeal fistula def: "A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site OR An abnormal communication between the larynx and another organ or cavity." [NCI:CTCAE, NCIT:C78410] xref: UMLS:C1699588 xref: NCI:CTCAE:10065786 xref: NCIT:C78410 property_value: ESCORT_rule "CCTO:001017 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngeal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001017 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngeal fistula'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001017(time_t t0) = EVENT_STATE(CCTO:001017, t0)" xsd:string ! schema ''Laryngeal fistula''(time_t t0) = EVENT_STATE(''Laryngeal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001018 name: Laryngeal hemorrhage def: "Bleeding originating from the larynx OR A disorder characterized by bleeding from the larynx." [NCIT:C78411, NCI:CTCAE] xref: UMLS:C1697747 xref: NCI:CTCAE:10065759 xref: NCIT:C78411 property_value: ESCORT_rule "CCTO:001018 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngeal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001018 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngeal hemorrhage'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001018(time_t t0) = EVENT_STATE(CCTO:001018, t0)" xsd:string ! schema ''Laryngeal hemorrhage''(time_t t0) = EVENT_STATE(''Laryngeal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001019 name: Laryngeal mucositis def: "A disorder characterized by an inflammation involving the mucous membrane of the larynx OR An inflammatory process affecting the mucous membrane of the larynx." [NCI:CTCAE, NCIT:C78412] xref: UMLS:C1698768 xref: NCI:CTCAE:10065880 xref: NCIT:C78412 property_value: ESCORT_rule "CCTO:001019 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngeal mucositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001019 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngeal mucositis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001019(time_t t0) = EVENT_STATE(CCTO:001019, t0)" xsd:string ! schema ''Laryngeal mucositis''(time_t t0) = EVENT_STATE(''Laryngeal mucositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001020 name: Laryngeal obstruction def: "A disorder characterized by blockage of the laryngeal airway OR Blockage of the laryngeal airway passage." [NCI:CTCAE, NCIT:C78413] xref: UMLS:C0264306 xref: NCI:CTCAE:10059639 xref: NCIT:C78413 property_value: ESCORT_rule "CCTO:001020 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngeal obstruction'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001020 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngeal obstruction'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001020(time_t t0) = EVENT_STATE(CCTO:001020, t0)" xsd:string ! schema ''Laryngeal obstruction''(time_t t0) = EVENT_STATE(''Laryngeal obstruction'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001021 name: Laryngeal stenosis def: "Narrowing of the laryngeal airway OR A disorder characterized by a narrowing of the laryngeal airway." [NCIT:C79608, NCI:CTCAE] xref: UMLS:C0023075 xref: NCI:CTCAE:10023862 xref: NCIT:C79608 property_value: ESCORT_rule "CCTO:001021 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngeal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001021 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngeal stenosis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001021(time_t t0) = EVENT_STATE(CCTO:001021, t0)" xsd:string ! schema ''Laryngeal stenosis''(time_t t0) = EVENT_STATE(''Laryngeal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001022 name: Laryngopharyngeal dysesthesia def: "A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx OR A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx." [NCI:CTCAE, NCIT:C78414] xref: UMLS:C1328466 xref: NCI:CTCAE:10062667 xref: NCIT:C78414 property_value: ESCORT_rule "CCTO:001022 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngopharyngeal dysesthesia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001022 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngopharyngeal dysesthesia'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001022(time_t t0) = EVENT_STATE(CCTO:001022, t0)" xsd:string ! schema ''Laryngopharyngeal dysesthesia''(time_t t0) = EVENT_STATE(''Laryngopharyngeal dysesthesia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001023 name: Laryngospasm def: "Paroxysmal spasmodic muscular contraction of the vocal cords. It is brief, usually lasting for less than one minute, interrupting the speech and breathing and may produce a high-pitched breathing sound. It may occur under anesthesia or may be associated with gastroesophageal reflex disease OR A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords." [NCIT:C79609, NCI:CTCAE] xref: UMLS:C0023066 xref: NCI:CTCAE:10023891 xref: NCIT:C79609 property_value: ESCORT_rule "CCTO:001023 implies CCTO:000049" xsd:string ! ESCORT_rule ''Laryngospasm'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001023 implies CCTO:001127" xsd:string ! ESCORT_rule ''Laryngospasm'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001023(time_t t0) = EVENT_STATE(CCTO:001023, t0)" xsd:string ! schema ''Laryngospasm''(time_t t0) = EVENT_STATE(''Laryngospasm'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001024 name: Mediastinal hemorrhage def: "A disorder characterized by bleeding from the mediastinum OR Bleeding originating from the mediastinum." [NCI:CTCAE, NCIT:C78443] xref: UMLS:C1112480 xref: NCI:CTCAE:10056356 xref: NCIT:C78443 property_value: ESCORT_rule "CCTO:001024 implies CCTO:000049" xsd:string ! ESCORT_rule ''Mediastinal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001024 implies CCTO:001127" xsd:string ! ESCORT_rule ''Mediastinal hemorrhage'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001024(time_t t0) = EVENT_STATE(CCTO:001024, t0)" xsd:string ! schema ''Mediastinal hemorrhage''(time_t t0) = EVENT_STATE(''Mediastinal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001025 name: Nasal congestion def: "A disorder characterized by obstruction of the nasal passage due to mucosal edema OR The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction." [NCI:CTCAE, NCIT:C78500] synonym: "Nasal stuffiness" EXACT [NCIT:C78500] xref: UMLS:C0027424 xref: NCI:CTCAE:10028735 xref: NCIT:C78500 property_value: ESCORT_rule "CCTO:001025 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nasal congestion'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001025 implies CCTO:001127" xsd:string ! ESCORT_rule ''Nasal congestion'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001025(time_t t0) = EVENT_STATE(CCTO:001025, t0)" xsd:string ! schema ''Nasal congestion''(time_t t0) = EVENT_STATE(''Nasal congestion'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001026 name: Pharyngeal fistula def: "An abnormal communication between the pharynx and another organ or anatomic site OR A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site." [NCIT:C78551, NCI:CTCAE] xref: UMLS:C1536454 xref: NCI:CTCAE:10034825 xref: NCIT:C78551 property_value: ESCORT_rule "CCTO:001026 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngeal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001026 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngeal fistula'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001026(time_t t0) = EVENT_STATE(CCTO:001026, t0)" xsd:string ! schema ''Pharyngeal fistula''(time_t t0) = EVENT_STATE(''Pharyngeal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001027 name: Pharyngeal hemorrhage def: "A disorder characterized by bleeding from the pharynx OR Bleeding originating from the pharynx." [NCI:CTCAE, NCIT:C26986] xref: UMLS:C0576995 xref: NCI:CTCAE:10055315 xref: NCIT:C26986 property_value: ESCORT_rule "CCTO:001027 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngeal hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001027 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngeal hemorrhage'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001027(time_t t0) = EVENT_STATE(CCTO:001027, t0)" xsd:string ! schema ''Pharyngeal hemorrhage''(time_t t0) = EVENT_STATE(''Pharyngeal hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001028 name: Pharyngeal mucositis def: "A disorder characterized by an inflammation involving the mucous membrane of the pharynx OR An inflammatory process affecting the mucous membrane of the pharynx." [NCI:CTCAE, NCIT:C78553] xref: UMLS:C1699324 xref: NCI:CTCAE:10065881 xref: NCIT:C78553 property_value: ESCORT_rule "CCTO:001028 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngeal mucositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001028 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngeal mucositis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001028(time_t t0) = EVENT_STATE(CCTO:001028, t0)" xsd:string ! schema ''Pharyngeal mucositis''(time_t t0) = EVENT_STATE(''Pharyngeal mucositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001029 name: Pharyngeal necrosis def: "A necrotic process affecting the pharynx OR A disorder characterized by a necrotic process occurring in the pharynx." [NCIT:C78554, NCI:CTCAE] synonym: "Pharyngeal necrotic lesion" EXACT [NCIT:C78554] xref: UMLS:C1696156 xref: NCI:CTCAE:10065706 xref: NCIT:C78554 property_value: ESCORT_rule "CCTO:001029 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngeal necrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001029 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngeal necrosis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001029(time_t t0) = EVENT_STATE(CCTO:001029, t0)" xsd:string ! schema ''Pharyngeal necrosis''(time_t t0) = EVENT_STATE(''Pharyngeal necrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001030 name: Pharyngeal stenosis def: "A disorder characterized by a narrowing of the pharyngeal airway OR Narrowing of the pharyngeal airway." [NCI:CTCAE, NCIT:C78555] xref: UMLS:C0396006 xref: NCI:CTCAE:10050028 xref: NCIT:C78555 property_value: ESCORT_rule "CCTO:001030 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pharyngeal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001030 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngeal stenosis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001030(time_t t0) = EVENT_STATE(CCTO:001030, t0)" xsd:string ! schema ''Pharyngeal stenosis''(time_t t0) = EVENT_STATE(''Pharyngeal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001031 name: Pharyngolaryngeal pain def: "A disorder characterized by marked discomfort sensation in the pharyngolaryngeal region OR Painful sensation in the pharyngolaryngeal region." [NCI:CTCAE, NCIT:C78556] xref: UMLS:C0858635 xref: NCI:CTCAE:10034844 xref: NCIT:C78556 property_value: ESCORT_rule "CCTO:001031 implies CCTO:000107" xsd:string ! ESCORT_rule ''Pharyngolaryngeal pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:001031 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pharyngolaryngeal pain'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001031(time_t t0) = EVENT_STATE(CCTO:001031, t0)" xsd:string ! schema ''Pharyngolaryngeal pain''(time_t t0) = EVENT_STATE(''Pharyngolaryngeal pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001032 name: Pleural effusion def: "A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort OR Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma." [NCI:CTCAE, NCIT:C3331] synonym: "Effusion, pleural" EXACT [NCIT:C3331] synonym: "Pleural effusion, NOS" EXACT [NCIT:C3331] xref: UMLS:C0032227 xref: UMLS:C1253943 xref: NCI:CTCAE:10035598 xref: NCIT:C3331 property_value: ESCORT_rule "CCTO:001032 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pleural effusion'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001032 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pleural effusion'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001032(time_t t0) = EVENT_STATE(CCTO:001032, t0)" xsd:string ! schema ''Pleural effusion''(time_t t0) = EVENT_STATE(''Pleural effusion'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001033 name: Pleural hemorrhage def: "A disorder characterized by bleeding from the pleural cavity OR A collection of blood in the pleural cavity." [NCI:CTCAE, NCIT:C50582] synonym: "Hemothorax" EXACT [NCIT:C50582] xref: UMLS:C0019123 xref: NCI:CTCAE:10055319 xref: NCIT:C50582 xref: NCIT:C78562 property_value: ESCORT_rule "CCTO:001033 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pleural hemorrhage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001033 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pleural hemorrhage'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001033(time_t t0) = EVENT_STATE(CCTO:001033, t0)" xsd:string ! schema ''Pleural hemorrhage''(time_t t0) = EVENT_STATE(''Pleural hemorrhage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001034 name: Pleuritic pain def: "A disorder characterized by marked discomfort sensation in the pleura OR Painful sensation in the pleura." [NCI:CTCAE, NCIT:C78564] xref: UMLS:C0008033 xref: NCI:CTCAE:10035623 xref: NCIT:C78564 property_value: ESCORT_rule "CCTO:001034 implies CCTO:000107" xsd:string ! ESCORT_rule ''Pleuritic pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:001034 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pleuritic pain'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001034(time_t t0) = EVENT_STATE(CCTO:001034, t0)" xsd:string ! schema ''Pleuritic pain''(time_t t0) = EVENT_STATE(''Pleuritic pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001035 name: Pneumonitis def: "An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia OR A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma." [NCIT:C113159, NCI:CTCAE] xref: UMLS:C3714636 xref: NCI:CTCAE:10035742 xref: NCIT:C113159 property_value: ESCORT_rule "CCTO:001035 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pneumonitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001035 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pneumonitis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001035(time_t t0) = EVENT_STATE(CCTO:001035, t0)" xsd:string ! schema ''Pneumonitis''(time_t t0) = EVENT_STATE(''Pneumonitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001036 name: Pneumothorax def: "Abnormal presence of air in the pleural cavity OR A disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung." [NCIT:C38006, NCI:CTCAE] synonym: "Pneumothorax adverse event" EXACT [NCIT:C58201] xref: UMLS:C0032326 xref: UMLS:C1963215 xref: NCI:CTCAE:10035759 xref: NCIT:C38006 xref: NCIT:C58201 property_value: ESCORT_rule "CCTO:001036 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pneumothorax'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001036 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pneumothorax'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001036(time_t t0) = EVENT_STATE(CCTO:001036, t0)" xsd:string ! schema ''Pneumothorax''(time_t t0) = EVENT_STATE(''Pneumothorax'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001037 name: Postnasal drip def: "Excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. It is usually due to allergic rhinitis or a cold OR A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing." [NCIT:C78566, NCI:CTCAE] synonym: "Post-nasal drip" EXACT [NCIT:C78566] xref: UMLS:C0032781 xref: NCI:CTCAE:10036402 xref: NCIT:C78566 property_value: ESCORT_rule "CCTO:001037 implies CCTO:000049" xsd:string ! ESCORT_rule ''Postnasal drip'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001037 implies CCTO:001127" xsd:string ! ESCORT_rule ''Postnasal drip'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001037(time_t t0) = EVENT_STATE(CCTO:001037, t0)" xsd:string ! schema ''Postnasal drip''(time_t t0) = EVENT_STATE(''Postnasal drip'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001038 name: Productive cough def: "A cough accompanied by expectorated secretions OR A disorder characterized by expectorated secretions upon coughing." [NCIT:C78569, NCI:CTCAE] synonym: "Loose cough" EXACT [NCIT:C78569] synonym: "Wet cough" EXACT [NCIT:C78569] xref: UMLS:C0239134 xref: NCI:CTCAE:10036790 xref: NCIT:C78569 property_value: ESCORT_rule "CCTO:001038 implies CCTO:000049" xsd:string ! ESCORT_rule ''Productive cough'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001038 implies CCTO:001127" xsd:string ! ESCORT_rule ''Productive cough'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001038(time_t t0) = EVENT_STATE(CCTO:001038, t0)" xsd:string ! schema ''Productive cough''(time_t t0) = EVENT_STATE(''Productive cough'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001039 name: Pulmonary edema def: "Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure) OR A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure." [NCIT:C26868, NCI:CTCAE] synonym: "Edema, pulmonary" EXACT [NCIT:C26868] xref: UMLS:C0034063 xref: NCI:CTCAE:10037375 xref: NCIT:C26868 property_value: ESCORT_rule "CCTO:001039 implies CCTO:000226" xsd:string ! ESCORT_rule ''Pulmonary edema'' implies ''Edema'' property_value: ESCORT_rule "CCTO:001039 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pulmonary edema'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001039(time_t t0) = EVENT_STATE(CCTO:001039, t0)" xsd:string ! schema ''Pulmonary edema''(time_t t0) = EVENT_STATE(''Pulmonary edema'', t0) is_a: CCTO:000226 ! Edema is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001040 name: Pulmonary fibrosis def: "Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause) OR A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure." [NCIT:C26869, NCI:CTCAE] synonym: "Pulmonary interstitial fibrosis" EXACT [NCIT:C26869] xref: UMLS:C0034069 xref: UMLS:C0240035 xref: NCI:CTCAE:10037383 xref: NCIT:C26869 property_value: ESCORT_rule "CCTO:001040 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pulmonary fibrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001040 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pulmonary fibrosis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001040(time_t t0) = EVENT_STATE(CCTO:001040, t0)" xsd:string ! schema ''Pulmonary fibrosis''(time_t t0) = EVENT_STATE(''Pulmonary fibrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001041 name: Pulmonary fistula def: "An abnormal communication between the lung and another organ or anatomic site OR A disorder characterized by an abnormal communication between the lung and another organ or anatomic site." [NCIT:C78577, NCI:CTCAE] xref: UMLS:C1397452 xref: NCI:CTCAE:10065873 xref: NCIT:C78577 property_value: ESCORT_rule "CCTO:001041 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pulmonary fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001041 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pulmonary fistula'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001041(time_t t0) = EVENT_STATE(CCTO:001041, t0)" xsd:string ! schema ''Pulmonary fistula''(time_t t0) = EVENT_STATE(''Pulmonary fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001042 name: Pulmonary hypertension def: "Increased pressure within the pulmonary circulation due to lung or heart disorder OR A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder." [NCIT:C3120, NCI:CTCAE] synonym: "Pulmonary hypertension adverse event" EXACT [NCIT:C55068] xref: UMLS:C0020542 xref: UMLS:C1963220 xref: NCI:CTCAE:10037400 xref: NCIT:C3120 xref: NCIT:C55068 property_value: ESCORT_rule "CCTO:001042 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pulmonary hypertension'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001042 implies CCTO:001127" xsd:string ! ESCORT_rule ''Pulmonary hypertension'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001042(time_t t0) = EVENT_STATE(CCTO:001042, t0)" xsd:string ! schema ''Pulmonary hypertension''(time_t t0) = EVENT_STATE(''Pulmonary hypertension'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001043 name: Respiratory failure def: "The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function OR A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide." [NCIT:C26872, NCI:CTCAE] synonym: "Failure, respiratory" EXACT [NCIT:C26872] xref: UMLS:C1145670 xref: NCI:CTCAE:10038695 xref: NCIT:C26872 property_value: ESCORT_rule "CCTO:001043 implies CCTO:000049" xsd:string ! ESCORT_rule ''Respiratory failure'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001043 implies CCTO:001127" xsd:string ! ESCORT_rule ''Respiratory failure'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001043(time_t t0) = EVENT_STATE(CCTO:001043, t0)" xsd:string ! schema ''Respiratory failure''(time_t t0) = EVENT_STATE(''Respiratory failure'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001044 name: Retinoic acid syndrome def: "A syndrome observed in patients with acute promyelocytic leukemia treated with all-trans retinoic acid. It is characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis, and renal failure OR A disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid." [NCIT:C78597, NCI:CTCAE] synonym: "APL Differentiation Syndrome" EXACT [NCIT:C78597] synonym: "Differentiation syndrome" EXACT [NCIT:C78597] synonym: "Retinoic acid syndrome adverse event" EXACT [NCIT:C56635] xref: UMLS:C0860564 xref: UMLS:C1962967 xref: NCI:CTCAE:10038921 xref: NCIT:C56635 xref: NCIT:C78597 property_value: ESCORT_rule "CCTO:001044 implies CCTO:000049" xsd:string ! ESCORT_rule ''Retinoic acid syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001044 implies CCTO:001127" xsd:string ! ESCORT_rule ''Retinoic acid syndrome'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001044(time_t t0) = EVENT_STATE(CCTO:001044, t0)" xsd:string ! schema ''Retinoic acid syndrome''(time_t t0) = EVENT_STATE(''Retinoic acid syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001045 name: Sinus disorder def: "A non-neoplastic or neoplastic disorder affecting the paranasal sinuses. Examples include inflammation, polyps, and cancer OR A disorder characterized by involvement of the paranasal sinuses." [NCIT:C26843, NCI:CTCAE] synonym: "Paranasal sinus disease" EXACT [NCIT:C26843] synonym: "Paranasal sinus disorder" EXACT [NCIT:C26843] xref: UMLS:C0030469 xref: NCI:CTCAE:10062244 xref: NCIT:C26843 property_value: ESCORT_rule "CCTO:001045 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sinus disorder'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001045 implies CCTO:001127" xsd:string ! ESCORT_rule ''Sinus disorder'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001045(time_t t0) = EVENT_STATE(CCTO:001045, t0)" xsd:string ! schema ''Sinus disorder''(time_t t0) = EVENT_STATE(''Sinus disorder'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001046 name: Sleep apnea def: "Cessation of breathing for short periods during sleep. It is classified as obstructive, central, or mixed obstructive-central. It can occur at any age but it is more frequent in people over forty. Risk factors include male sex and obesity OR A disorder characterized by cessation of breathing for short periods during sleep." [NCIT:C26884, NCI:CTCAE] xref: UMLS:C0037315 xref: NCI:CTCAE:10040975 xref: NCIT:C26884 property_value: ESCORT_rule "CCTO:001046 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sleep apnea'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001046 implies CCTO:001127" xsd:string ! ESCORT_rule ''Sleep apnea'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001046(time_t t0) = EVENT_STATE(CCTO:001046, t0)" xsd:string ! schema ''Sleep apnea''(time_t t0) = EVENT_STATE(''Sleep apnea'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001047 name: Sneezing def: "A symptom consisting of the involuntary expulsion of air from the nose OR A disorder characterized by the involuntary expulsion of air from the nose." [NCIT:C50746, NCI:CTCAE] xref: UMLS:C0037383 xref: NCI:CTCAE:10041232 xref: NCIT:C50746 property_value: ESCORT_rule "CCTO:001047 implies CCTO:000049" xsd:string ! ESCORT_rule ''Sneezing'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001047 implies CCTO:001127" xsd:string ! ESCORT_rule ''Sneezing'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001047(time_t t0) = EVENT_STATE(CCTO:001047, t0)" xsd:string ! schema ''Sneezing''(time_t t0) = EVENT_STATE(''Sneezing'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001048 name: Stridor def: "A disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction OR A symptom resulting from laryngeal obstruction. It is characterized by a high pitched breathing sound." [NCI:CTCAE, NCIT:C78632] xref: UMLS:C0038450 xref: NCI:CTCAE:10042241 xref: NCIT:C78632 property_value: ESCORT_rule "CCTO:001048 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stridor'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001048 implies CCTO:001127" xsd:string ! ESCORT_rule ''Stridor'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001048(time_t t0) = EVENT_STATE(CCTO:001048, t0)" xsd:string ! schema ''Stridor''(time_t t0) = EVENT_STATE(''Stridor'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001049 name: Tracheal fistula def: "A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site OR An abnormal communication between the trachea and another organ or anatomic site." [NCI:CTCAE, NCIT:C78641] xref: UMLS:C0340214 xref: NCI:CTCAE:10065787 xref: NCIT:C78641 property_value: ESCORT_rule "CCTO:001049 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheal fistula'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001049 implies CCTO:001127" xsd:string ! ESCORT_rule ''Tracheal fistula'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001049(time_t t0) = EVENT_STATE(CCTO:001049, t0)" xsd:string ! schema ''Tracheal fistula''(time_t t0) = EVENT_STATE(''Tracheal fistula'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001050 name: Tracheal mucositis def: "A disorder characterized by an inflammation involving the mucous membrane of the trachea OR An inflammatory process affecting the mucous membrane of the trachea." [NCI:CTCAE, NCIT:C78644] xref: UMLS:C1699329 xref: NCI:CTCAE:10065900 xref: NCIT:C78644 property_value: ESCORT_rule "CCTO:001050 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheal mucositis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001050 implies CCTO:001127" xsd:string ! ESCORT_rule ''Tracheal mucositis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001050(time_t t0) = EVENT_STATE(CCTO:001050, t0)" xsd:string ! schema ''Tracheal mucositis''(time_t t0) = EVENT_STATE(''Tracheal mucositis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001051 name: Tracheal stenosis def: "Narrowing of the lumen of the trachea OR A disorder characterized by a narrowing of the trachea." [NCIT:C78646, NCI:CTCAE] xref: UMLS:C0040583 xref: NCI:CTCAE:10050816 xref: NCIT:C78646 property_value: ESCORT_rule "CCTO:001051 implies CCTO:000049" xsd:string ! ESCORT_rule ''Tracheal stenosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001051 implies CCTO:001127" xsd:string ! ESCORT_rule ''Tracheal stenosis'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001051(time_t t0) = EVENT_STATE(CCTO:001051, t0)" xsd:string ! schema ''Tracheal stenosis''(time_t t0) = EVENT_STATE(''Tracheal stenosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001052 name: Voice alteration def: "A disorder characterized by a change in the sound and/or speed of the voice OR Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury." [NCI:CTCAE, NCIT:C61043] synonym: "Change in Voice" EXACT [NCIT:C61043] xref: UMLS:C0518179 xref: UMLS:C1527340 xref: NCI:CTCAE:10047681 xref: NCIT:C61043 property_value: ESCORT_rule "CCTO:001052 implies CCTO:000049" xsd:string ! ESCORT_rule ''Voice alteration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001052 implies CCTO:001127" xsd:string ! ESCORT_rule ''Voice alteration'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001052(time_t t0) = EVENT_STATE(CCTO:001052, t0)" xsd:string ! schema ''Voice alteration''(time_t t0) = EVENT_STATE(''Voice alteration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001053 name: Wheezing def: "A disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways OR A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema." [NCI:CTCAE, NCIT:C78718] synonym: "Wheeze" EXACT [NCIT:C78718] xref: UMLS:C0043144 xref: NCI:CTCAE:10047924 xref: NCIT:C78718 property_value: ESCORT_rule "CCTO:001053 implies CCTO:000049" xsd:string ! ESCORT_rule ''Wheezing'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001053 implies CCTO:001127" xsd:string ! ESCORT_rule ''Wheezing'' implies ''Respiratory, thoracic and mediastinal disorders'' property_value: schema "CCTO:001053(time_t t0) = EVENT_STATE(CCTO:001053, t0)" xsd:string ! schema ''Wheezing''(time_t t0) = EVENT_STATE(''Wheezing'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001127 ! Respiratory, thoracic and mediastinal disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001054 name: Alopecia def: "Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders or congenital conditions OR Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders, and congenital conditions OR A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location." [NCIT:C50575, NCIT:C2865, NCI:CTCAE] synonym: "Alopecia areata" EXACT [NCIT:C50575] synonym: "Hair loss" EXACT [NCIT:C50575] synonym: "Loss of hair" EXACT [NCIT:C50575] xref: UMLS:C0002170 xref: UMLS:C0002171 xref: NCI:CTCAE:10001760 xref: NCIT:C2865 xref: NCIT:C50575 property_value: ESCORT_rule "CCTO:001054 implies CCTO:000049" xsd:string ! ESCORT_rule ''Alopecia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001054 implies CCTO:001128" xsd:string ! ESCORT_rule ''Alopecia'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001054(time_t t0) = EVENT_STATE(CCTO:001054, t0)" xsd:string ! schema ''Alopecia''(time_t t0) = EVENT_STATE(''Alopecia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001055 name: Body odor def: "Body smell resulting from the growth of bacteria on the body OR A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body." [NCIT:C79542, NCI:CTCAE] xref: UMLS:C0085595 xref: NCI:CTCAE:10005901 xref: NCIT:C79542 property_value: ESCORT_rule "CCTO:001055 implies CCTO:000049" xsd:string ! ESCORT_rule ''Body odor'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001055 implies CCTO:001128" xsd:string ! ESCORT_rule ''Body odor'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001055(time_t t0) = EVENT_STATE(CCTO:001055, t0)" xsd:string ! schema ''Body odor''(time_t t0) = EVENT_STATE(''Body odor'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001056 name: Bullous dermatitis def: "A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid OR Inflammation of the skin characterized by the presence of bullae which are filled with fluid." [NCI:CTCAE, NCIT:C35149] xref: UMLS:C0085932 xref: NCI:CTCAE:10006556 xref: NCIT:C35149 property_value: ESCORT_rule "CCTO:001056 implies CCTO:000049" xsd:string ! ESCORT_rule ''Bullous dermatitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001056 implies CCTO:001128" xsd:string ! ESCORT_rule ''Bullous dermatitis'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001056(time_t t0) = EVENT_STATE(CCTO:001056, t0)" xsd:string ! schema ''Bullous dermatitis''(time_t t0) = EVENT_STATE(''Bullous dermatitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001057 name: Dry skin def: "A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture OR The pores are generally fine with a papery thin texture that feels dry to the touch. Usually flaky and dull looking." [NCI:CTCAE, NCIT:C74592] synonym: "DRY" EXACT [NCIT:C74592] synonym: "Dry skin adverse event" EXACT [NCIT:C57996] xref: UMLS:C0151908 xref: UMLS:C0205222 xref: UMLS:C0720057 xref: UMLS:C1963094 xref: NCI:CTCAE:10013786 xref: NCIT:C57996 xref: NCIT:C74592 property_value: ESCORT_rule "CCTO:001057 implies CCTO:000049" xsd:string ! ESCORT_rule ''Dry skin'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001057 implies CCTO:001128" xsd:string ! ESCORT_rule ''Dry skin'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001057(time_t t0) = EVENT_STATE(CCTO:001057, t0)" xsd:string ! schema ''Dry skin''(time_t t0) = EVENT_STATE(''Dry skin'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001058 name: Erythema multiforme def: "A hypersensitivity reaction characterized by the sudden appearance of symmetrical cutaneous and mucocutaneous macular or papular lesions which evolve into lesions with bright red borders (target lesions). The lesions usually appear in the hands, feet, extremities, and face. Symptoms include fever, malaise, sore throat, cough, vomiting, diarrhea, arthralgia, and myalgia. Causes include infections (most commonly herpes simplex virus), drugs (e.g., sulfonamides, anticonvulsants, and antibiotics), malignancies, and collagen vascular disorders OR A disorder characterized by target lesions (a pink-red ring around a pale center)." [NCIT:C3024, NCI:CTCAE] xref: UMLS:C0014742 xref: NCI:CTCAE:10015218 xref: NCIT:C3024 property_value: ESCORT_rule "CCTO:001058 implies CCTO:000049" xsd:string ! ESCORT_rule ''Erythema multiforme'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001058 implies CCTO:001128" xsd:string ! ESCORT_rule ''Erythema multiforme'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001058(time_t t0) = EVENT_STATE(CCTO:001058, t0)" xsd:string ! schema ''Erythema multiforme''(time_t t0) = EVENT_STATE(''Erythema multiforme'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001059 name: Erythroderma def: "A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area OR A generalized inflammatory cutaneous disorder characterized by erythema and desquamation." [NCI:CTCAE, NCIT:C39646] synonym: "Exfoliative dermatitis" EXACT [NCIT:C39646] xref: UMLS:C0011606 xref: NCI:CTCAE:10015277 xref: NCIT:C39646 property_value: ESCORT_rule "CCTO:001059 implies CCTO:000049" xsd:string ! ESCORT_rule ''Erythroderma'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001059 implies CCTO:001128" xsd:string ! ESCORT_rule ''Erythroderma'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001059(time_t t0) = EVENT_STATE(CCTO:001059, t0)" xsd:string ! schema ''Erythroderma''(time_t t0) = EVENT_STATE(''Erythroderma'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001060 name: Fat atrophy def: "A disorder characterized by shrinking of adipose tissue OR Shrinking of adipose tissue." [NCI:CTCAE, NCIT:C78297] synonym: "Adipose tissue atrophy" EXACT [NCIT:C78297] xref: UMLS:C0333650 xref: NCI:CTCAE:10016241 xref: NCIT:C78297 property_value: ESCORT_rule "CCTO:001060 implies CCTO:000049" xsd:string ! ESCORT_rule ''Fat atrophy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001060 implies CCTO:001128" xsd:string ! ESCORT_rule ''Fat atrophy'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001060(time_t t0) = EVENT_STATE(CCTO:001060, t0)" xsd:string ! schema ''Fat atrophy''(time_t t0) = EVENT_STATE(''Fat atrophy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001061 name: Hirsutism def: "A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) OR Male-pattern hair growth on a female." [NCI:CTCAE, NCIT:C61444] xref: UMLS:C0019572 xref: NCI:CTCAE:10020112 xref: NCIT:C61444 property_value: ESCORT_rule "CCTO:001061 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hirsutism'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001061 implies CCTO:001128" xsd:string ! ESCORT_rule ''Hirsutism'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001061(time_t t0) = EVENT_STATE(CCTO:001061, t0)" xsd:string ! schema ''Hirsutism''(time_t t0) = EVENT_STATE(''Hirsutism'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001062 name: Hyperhidrosis def: "A disorder characterized by excessive perspiration OR Excessive perspiration." [NCI:CTCAE, NCIT:C78345] synonym: "Hyperhydrosis" EXACT [NCIT:C78345] xref: UMLS:C0020458 xref: NCI:CTCAE:10020642 xref: NCIT:C78345 property_value: ESCORT_rule "CCTO:001062 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hyperhidrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001062 implies CCTO:001128" xsd:string ! ESCORT_rule ''Hyperhidrosis'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001062(time_t t0) = EVENT_STATE(CCTO:001062, t0)" xsd:string ! schema ''Hyperhidrosis''(time_t t0) = EVENT_STATE(''Hyperhidrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001063 name: Hypertrichosis def: "A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race OR Excessive hair growth anywhere on the body." [NCI:CTCAE, NCIT:C79597] xref: UMLS:C0020555 xref: NCI:CTCAE:10020864 xref: NCIT:C79597 property_value: ESCORT_rule "CCTO:001063 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypertrichosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001063 implies CCTO:001128" xsd:string ! ESCORT_rule ''Hypertrichosis'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001063(time_t t0) = EVENT_STATE(CCTO:001063, t0)" xsd:string ! schema ''Hypertrichosis''(time_t t0) = EVENT_STATE(''Hypertrichosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001064 name: Hypohidrosis def: "Reduced sweating. Causes include burns, dehydration, radiation, and leprosy OR A disorder characterized by reduced sweating." [NCIT:C34718, NCI:CTCAE] xref: UMLS:C0020620 xref: NCI:CTCAE:10021013 xref: NCIT:C34718 property_value: ESCORT_rule "CCTO:001064 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypohidrosis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001064 implies CCTO:001128" xsd:string ! ESCORT_rule ''Hypohidrosis'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001064(time_t t0) = EVENT_STATE(CCTO:001064, t0)" xsd:string ! schema ''Hypohidrosis''(time_t t0) = EVENT_STATE(''Hypohidrosis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001065 name: Lipohypertrophy def: "A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin OR Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin." [NCI:CTCAE, NCIT:C78436] xref: UMLS:C1262113 xref: NCI:CTCAE:10062315 xref: NCIT:C78436 property_value: ESCORT_rule "CCTO:001065 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lipohypertrophy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001065 implies CCTO:001128" xsd:string ! ESCORT_rule ''Lipohypertrophy'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001065(time_t t0) = EVENT_STATE(CCTO:001065, t0)" xsd:string ! schema ''Lipohypertrophy''(time_t t0) = EVENT_STATE(''Lipohypertrophy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001066 name: Nail discoloration def: "A disorder characterized by a change in the color of the nail plate OR A change in the color of the nail." [NCI:CTCAE, NCIT:C78492] synonym: "Chromonychia" EXACT [NCIT:C78492] synonym: "Pigmentary Change of Nails" EXACT [NCIT:C78492] xref: UMLS:C0221345 xref: NCI:CTCAE:10028691 xref: NCIT:C78492 property_value: ESCORT_rule "CCTO:001066 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nail discoloration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001066 implies CCTO:001128" xsd:string ! ESCORT_rule ''Nail discoloration'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001066(time_t t0) = EVENT_STATE(CCTO:001066, t0)" xsd:string ! schema ''Nail discoloration''(time_t t0) = EVENT_STATE(''Nail discoloration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001067 name: Nail loss def: "A disorder characterized by loss of all or a portion of the nail OR Loss of all or a portion of a nail." [NCI:CTCAE, NCIT:C78494] xref: UMLS:C0263540 xref: NCI:CTCAE:10049281 xref: NCIT:C78494 property_value: ESCORT_rule "CCTO:001067 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nail loss'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001067 implies CCTO:001128" xsd:string ! ESCORT_rule ''Nail loss'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001067(time_t t0) = EVENT_STATE(CCTO:001067, t0)" xsd:string ! schema ''Nail loss''(time_t t0) = EVENT_STATE(''Nail loss'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001068 name: Nail ridging def: "Straight elevated lines on the nail surface. Ridges may be vertical (running from the cuticle to the nail tip) or horizontal (running from one side of the nail to the other). Vertical ridges are usually not associated with underlying disorders and tend to become more pronounced with age. Horizontal ridges may be associated with metabolic disorders and malnutrition OR A disorder characterized by vertical or horizontal ridges on the nails." [NCIT:C78499, NCI:CTCAE] xref: UMLS:C0423820 xref: NCI:CTCAE:10062283 xref: NCIT:C78499 property_value: ESCORT_rule "CCTO:001068 implies CCTO:000049" xsd:string ! ESCORT_rule ''Nail ridging'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001068 implies CCTO:001128" xsd:string ! ESCORT_rule ''Nail ridging'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001068(time_t t0) = EVENT_STATE(CCTO:001068, t0)" xsd:string ! schema ''Nail ridging''(time_t t0) = EVENT_STATE(''Nail ridging'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001069 name: Pain of skin def: "Painful sensation in the skin OR A disorder characterized by marked discomfort sensation in the skin." [NCIT:C78516, NCI:CTCAE] synonym: "Skin pain" EXACT [NCIT:C78516] xref: UMLS:C0241136 xref: UMLS:C1963195 xref: NCI:CTCAE:10033474 xref: NCIT:C78516 property_value: ESCORT_rule "CCTO:001069 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pain of skin'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001069 implies CCTO:001128" xsd:string ! ESCORT_rule ''Pain of skin'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001069(time_t t0) = EVENT_STATE(CCTO:001069, t0)" xsd:string ! schema ''Pain of skin''(time_t t0) = EVENT_STATE(''Pain of skin'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001070 name: Palmar-plantar erythrodysesthesia syndrome def: "A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet OR A condition characterized by redness, pain, swelling, and tingling in the palms of the hands or the soles of the feet. It may appear as a side effect to chemotherapy agents." [NCI:CTCAE, NCIT:C27177] synonym: "Hand-foot syndrome" EXACT [NCIT:C27177] synonym: "Palmar-plantar erythodysthesia" EXACT [NCIT:C27177] synonym: "palmar-plantar erythrodysthesia" EXACT [NCIT:C27177] xref: UMLS:C0549410 xref: NCI:CTCAE:10054524 xref: NCIT:C27177 property_value: ESCORT_rule "CCTO:001070 implies CCTO:000049" xsd:string ! ESCORT_rule ''Palmar-plantar erythrodysesthesia syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001070 implies CCTO:001128" xsd:string ! ESCORT_rule ''Palmar-plantar erythrodysesthesia syndrome'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001070(time_t t0) = EVENT_STATE(CCTO:001070, t0)" xsd:string ! schema ''Palmar-plantar erythrodysesthesia syndrome''(time_t t0) = EVENT_STATE(''Palmar-plantar erythrodysesthesia syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001071 name: Periorbital edema def: "Swelling due to an excessive accumulation of fluid around the orbits of the face OR A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face." [NCIT:C78530, NCI:CTCAE] xref: UMLS:C0151205 xref: NCI:CTCAE:10054541 xref: NCIT:C78530 property_value: ESCORT_rule "CCTO:001071 implies CCTO:000226" xsd:string ! ESCORT_rule ''Periorbital edema'' implies ''Edema'' property_value: ESCORT_rule "CCTO:001071 implies CCTO:001128" xsd:string ! ESCORT_rule ''Periorbital edema'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001071(time_t t0) = EVENT_STATE(CCTO:001071, t0)" xsd:string ! schema ''Periorbital edema''(time_t t0) = EVENT_STATE(''Periorbital edema'', t0) is_a: CCTO:000226 ! Edema is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001072 name: Photosensitivity def: "A disorder characterized by an increase in sensitivity of the skin to light OR Increased sensitivity of the skin to light exposure." [NCI:CTCAE, NCIT:C38004] synonym: "Photosensitivity adverse event" EXACT [NCIT:C58005] synonym: "Skin photosensitivity" EXACT [NCIT:C38004] xref: UMLS:C0349506 xref: UMLS:C2362621 xref: UMLS:C1868677 xref: NCI:CTCAE:10034966 xref: NCIT:C38004 xref: NCIT:C58005 property_value: ESCORT_rule "CCTO:001072 implies CCTO:000049" xsd:string ! ESCORT_rule ''Photosensitivity'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001072 implies CCTO:001128" xsd:string ! ESCORT_rule ''Photosensitivity'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001072(time_t t0) = EVENT_STATE(CCTO:001072, t0)" xsd:string ! schema ''Photosensitivity''(time_t t0) = EVENT_STATE(''Photosensitivity'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001073 name: Pruritus def: "A disorder characterized by an intense itching sensation OR An intense itching sensation." [NCI:CTCAE, NCIT:C3344] synonym: "Itch" EXACT [NCIT:C3344] synonym: "Itching (pruritus)" EXACT [NCIT:C3344] synonym: "Itching" EXACT [NCIT:C3344] xref: UMLS:C0033774 xref: UMLS:C1422257 xref: NCI:CTCAE:10037087 xref: NCIT:C3344 property_value: ESCORT_rule "CCTO:001073 implies CCTO:000049" xsd:string ! ESCORT_rule ''Pruritus'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001073 implies CCTO:001128" xsd:string ! ESCORT_rule ''Pruritus'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001073(time_t t0) = EVENT_STATE(CCTO:001073, t0)" xsd:string ! schema ''Pruritus''(time_t t0) = EVENT_STATE(''Pruritus'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001074 name: Purpura def: "A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color OR A small blood vessel hemorrhage into the skin and/or mucous membranes. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color." [NCI:CTCAE, NCIT:C78787] xref: UMLS:C0034150 xref: UMLS:C3463943 xref: NCI:CTCAE:10037549 xref: NCIT:C78787 property_value: ESCORT_rule "CCTO:001074 implies CCTO:000049" xsd:string ! ESCORT_rule ''Purpura'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001074 implies CCTO:001128" xsd:string ! ESCORT_rule ''Purpura'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001074(time_t t0) = EVENT_STATE(CCTO:001074, t0)" xsd:string ! schema ''Purpura''(time_t t0) = EVENT_STATE(''Purpura'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001075 name: Rash acneiform def: "A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back OR Cutaneous eruptions resembling acne, characterized by the presence of papulonodules, pustules, comedones, or cysts in the face, trunk, and extremities. Causes include infections and the use of certain medications (e.g., antibiotics and steroids)." [NCI:CTCAE, NCIT:C35277] synonym: "Acneiform dermatitis" EXACT [NCIT:C35277] xref: UMLS:C0234894 xref: NCI:CTCAE:10037847 xref: NCIT:C35277 property_value: ESCORT_rule "CCTO:001075 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rash acneiform'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001075 implies CCTO:001128" xsd:string ! ESCORT_rule ''Rash acneiform'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001075(time_t t0) = EVENT_STATE(CCTO:001075, t0)" xsd:string ! schema ''Rash acneiform''(time_t t0) = EVENT_STATE(''Rash acneiform'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001076 name: Rash maculo-papular def: "A skin condition consisting of both macules and papules OR A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis." [NCIT:C75579, NCI:CTCAE] synonym: "Maculopapular lesion" EXACT [NCIT:C75579] xref: UMLS:C0423791 xref: NCI:CTCAE:10037868 xref: NCIT:C75579 property_value: ESCORT_rule "CCTO:001076 implies CCTO:000049" xsd:string ! ESCORT_rule ''Rash maculo-papular'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001076 implies CCTO:001128" xsd:string ! ESCORT_rule ''Rash maculo-papular'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001076(time_t t0) = EVENT_STATE(CCTO:001076, t0)" xsd:string ! schema ''Rash maculo-papular''(time_t t0) = EVENT_STATE(''Rash maculo-papular'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001077 name: Scalp pain def: "Painful sensation in the skin covering the top and the back of the head OR A disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head." [NCIT:C79716, NCI:CTCAE] synonym: "Scalp pain adverse event" EXACT [NCIT:C56210] xref: UMLS:C0240940 xref: UMLS:C1963231 xref: NCI:CTCAE:10049120 xref: NCIT:C56210 xref: NCIT:C79716 property_value: ESCORT_rule "CCTO:001077 implies CCTO:000107" xsd:string ! ESCORT_rule ''Scalp pain'' implies ''Pain'' property_value: ESCORT_rule "CCTO:001077 implies CCTO:001128" xsd:string ! ESCORT_rule ''Scalp pain'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001077(time_t t0) = EVENT_STATE(CCTO:001077, t0)" xsd:string ! schema ''Scalp pain''(time_t t0) = EVENT_STATE(''Scalp pain'', t0) is_a: CCTO:000107 ! Pain is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001078 name: Skin atrophy def: "The degeneration and thinning of the epidermis and dermis. It is usually a manifestation of aging OR A disorder characterized by the degeneration and thinning of the epidermis and dermis." [NCIT:C35163, NCI:CTCAE] synonym: "Atrophic skin" EXACT [NCIT:C35163] synonym: "Atrophy of Skin" EXACT [NCIT:C35163] xref: UMLS:C0151514 xref: NCI:CTCAE:10040799 xref: NCIT:C35163 property_value: ESCORT_rule "CCTO:001078 implies CCTO:000049" xsd:string ! ESCORT_rule ''Skin atrophy'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001078 implies CCTO:001128" xsd:string ! ESCORT_rule ''Skin atrophy'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001078(time_t t0) = EVENT_STATE(CCTO:001078, t0)" xsd:string ! schema ''Skin atrophy''(time_t t0) = EVENT_STATE(''Skin atrophy'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001079 name: Skin induration def: "A disorder characterized by an area of hardness in the skin OR An area of hardness in the skin. Causes include inflammatory process and infiltration of the skin by malignant neoplasms." [NCI:CTCAE, NCIT:C78611] xref: UMLS:C0241075 xref: NCI:CTCAE:10051837 xref: NCIT:C78611 property_value: ESCORT_rule "CCTO:001079 implies CCTO:000049" xsd:string ! ESCORT_rule ''Skin induration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001079 implies CCTO:001128" xsd:string ! ESCORT_rule ''Skin induration'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001079(time_t t0) = EVENT_STATE(CCTO:001079, t0)" xsd:string ! schema ''Skin induration''(time_t t0) = EVENT_STATE(''Skin induration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001080 name: Skin ulceration def: "A disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin OR A circumscribed and often suppurating skin crater which usually includes loss of skin integrity of the superficial skin or the mucous membranes." [NCI:CTCAE, NCIT:C54247] synonym: "Skin ulcer" EXACT [NCIT:C54247] xref: UMLS:C0037299 xref: NCI:CTCAE:10040947 xref: NCIT:C54247 property_value: ESCORT_rule "CCTO:001080 implies CCTO:000049" xsd:string ! ESCORT_rule ''Skin ulceration'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001080 implies CCTO:001128" xsd:string ! ESCORT_rule ''Skin ulceration'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001080(time_t t0) = EVENT_STATE(CCTO:001080, t0)" xsd:string ! schema ''Skin ulceration''(time_t t0) = EVENT_STATE(''Skin ulceration'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001081 name: Stevens-Johnson syndrome def: "A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma) OR A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes." [NCIT:C79484, NCI:CTCAE] synonym: "Erythema multiforme major" EXACT [NCIT:C79484] synonym: "Stevens johnson syndrome" EXACT [NCIT:C79484] xref: UMLS:C0038325 xref: UMLS:C3241919 xref: NCI:CTCAE:10042033 xref: NCIT:C79484 property_value: ESCORT_rule "CCTO:001081 implies CCTO:000049" xsd:string ! ESCORT_rule ''Stevens-Johnson syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001081 implies CCTO:001128" xsd:string ! ESCORT_rule ''Stevens-Johnson syndrome'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001081(time_t t0) = EVENT_STATE(CCTO:001081, t0)" xsd:string ! schema ''Stevens-Johnson syndrome''(time_t t0) = EVENT_STATE(''Stevens-Johnson syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001082 name: Telangiectasia def: "Local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes OR A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes." [NCIT:C28194, NCI:CTCAE] synonym: "Telangiectasia adverse event" EXACT [NCIT:C58017] xref: UMLS:C0039446 xref: UMLS:C1963248 xref: NCI:CTCAE:10043189 xref: NCIT:C28194 xref: NCIT:C58017 property_value: ESCORT_rule "CCTO:001082 implies CCTO:000049" xsd:string ! ESCORT_rule ''Telangiectasia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001082 implies CCTO:001128" xsd:string ! ESCORT_rule ''Telangiectasia'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001082(time_t t0) = EVENT_STATE(CCTO:001082, t0)" xsd:string ! schema ''Telangiectasia''(time_t t0) = EVENT_STATE(''Telangiectasia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001083 name: Toxic epidermal necrolysis def: "A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes OR A systemic, serious, and life-threatening disorder characterized by erythematous and necrotic lesions in the skin and mucous membranes that are associated with bullous detachment of the epidermis. The epidermal and mucous membranes detachment leads to sepsis and may be fatal. The lesions appear throughout the body and occupy more than 30% of the body surfaces. It is a hypersensitivity reaction usually caused by drugs (e.g., sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and antiretroviral drugs)." [NCI:CTCAE, NCIT:C79777] synonym: "Lyell syndrome" EXACT [NCIT:C79777] synonym: "Lyell's Syndrome" EXACT [NCIT:C79777] synonym: "TEN" EXACT [NCIT:C79777] xref: UMLS:C0014518 xref: UMLS:C0205456 xref: NCI:CTCAE:10044223 xref: NCIT:C79777 property_value: ESCORT_rule "CCTO:001083 implies CCTO:000049" xsd:string ! ESCORT_rule ''Toxic epidermal necrolysis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001083 implies CCTO:001128" xsd:string ! ESCORT_rule ''Toxic epidermal necrolysis'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001083(time_t t0) = EVENT_STATE(CCTO:001083, t0)" xsd:string ! schema ''Toxic epidermal necrolysis''(time_t t0) = EVENT_STATE(''Toxic epidermal necrolysis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001084 name: Urticaria def: "A disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins OR A transient, itchy skin eruption characterized by wheals with pale interiors and red margins." [NCI:CTCAE, NCIT:C3432] synonym: "Hives" EXACT [NCIT:C3432] xref: UMLS:C0042109 xref: NCI:CTCAE:10046735 xref: NCIT:C3432 property_value: ESCORT_rule "CCTO:001084 implies CCTO:000049" xsd:string ! ESCORT_rule ''Urticaria'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001084 implies CCTO:001128" xsd:string ! ESCORT_rule ''Urticaria'' implies ''Skin and subcutaneous tissue disorders'' property_value: schema "CCTO:001084(time_t t0) = EVENT_STATE(CCTO:001084, t0)" xsd:string ! schema ''Urticaria''(time_t t0) = EVENT_STATE(''Urticaria'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001128 ! Skin and subcutaneous tissue disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001085 name: Menopause def: "A disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age OR The permanent cessation of menses, usually defined by 6 to 12 months of amenorrhea in a woman over 45 years of age." [NCI:CTCAE, NCIT:C3231] synonym: "Menopausal" EXACT [NCIT:C3231] xref: UMLS:C0025320 xref: NCI:CTCAE:10027308 xref: NCIT:C3231 property_value: ESCORT_rule "CCTO:001085 implies CCTO:000049" xsd:string ! ESCORT_rule ''Menopause'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001085 implies CCTO:001129" xsd:string ! ESCORT_rule ''Menopause'' implies ''Social circumstances'' property_value: schema "CCTO:001085(time_t t0) = EVENT_STATE(CCTO:001085, t0)" xsd:string ! schema ''Menopause''(time_t t0) = EVENT_STATE(''Menopause'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001129 ! Social circumstances relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001086 name: Capillary leak syndrome def: "A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure OR A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure." [NCI:CTCAE, NCIT:C62578] synonym: "AVLS" EXACT [NCIT:C62578] synonym: "Acute vascular leak syndrome" EXACT [NCIT:C62578] synonym: "CLS" EXACT [NCIT:C62578] xref: UMLS:C0343084 xref: UMLS:C0265252 xref: UMLS:C1558951 xref: NCI:CTCAE:10007196 xref: NCIT:C62578 property_value: ESCORT_rule "CCTO:001086 implies CCTO:000049" xsd:string ! ESCORT_rule ''Capillary leak syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001086 implies CCTO:001130" xsd:string ! ESCORT_rule ''Capillary leak syndrome'' implies ''Vascular disorders'' property_value: schema "CCTO:001086(time_t t0) = EVENT_STATE(CCTO:001086, t0)" xsd:string ! schema ''Capillary leak syndrome''(time_t t0) = EVENT_STATE(''Capillary leak syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001087 name: Flushing def: "Reddening of the skin from a transient increase in blood flow OR A disorder characterized by episodic reddening of the face." [NCIT:C26775, NCI:CTCAE] synonym: "Flushed" EXACT [NCIT:C26775] synonym: "Flushing adverse event" EXACT [NCIT:C57997] xref: UMLS:C0016382 xref: UMLS:C1962957 xref: NCI:CTCAE:10016825 xref: NCIT:C26775 xref: NCIT:C57997 property_value: ESCORT_rule "CCTO:001087 implies CCTO:000049" xsd:string ! ESCORT_rule ''Flushing'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001087 implies CCTO:001130" xsd:string ! ESCORT_rule ''Flushing'' implies ''Vascular disorders'' property_value: schema "CCTO:001087(time_t t0) = EVENT_STATE(CCTO:001087, t0)" xsd:string ! schema ''Flushing''(time_t t0) = EVENT_STATE(''Flushing'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001088 name: Hematoma def: "A disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel OR A localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel." [NCI:CTCAE, NCIT:C50579] synonym: "Hematoma adverse event" EXACT [NCIT:C56539] xref: UMLS:C1962958 xref: UMLS:C0018944 xref: NCI:CTCAE:10019428 xref: NCIT:C50579 xref: NCIT:C56539 property_value: ESCORT_rule "CCTO:001088 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hematoma'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001088 implies CCTO:001130" xsd:string ! ESCORT_rule ''Hematoma'' implies ''Vascular disorders'' property_value: schema "CCTO:001088(time_t t0) = EVENT_STATE(CCTO:001088, t0)" xsd:string ! schema ''Hematoma''(time_t t0) = EVENT_STATE(''Hematoma'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001089 name: Hot flashes def: "A disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling OR A temporary feeling of intense body warmth, flushing, sometimes accompanied by sweating. A common, symptom of menopause; other conditions that can produce hot flushes include antidepressants and drugs blocking the effect of estrogens, carcinoid tumors and a sensitivity to sulfites or other food additives OR A question about an individual's assessment of how big a problem hot flashes have been OR A question about whether an individual is or was bothered by hot flashes." [NCI:CTCAE, NCIT:C3109, NCIT:C125055, NCIT:C125645] synonym: "Bothered by Hot Flashes" EXACT [NCIT:C125645] synonym: "Flashes, hot" EXACT [NCIT:C3109] synonym: "Hot flash" EXACT [NCIT:C3109] synonym: "How Big a Problem Are Hot Flashes" EXACT [NCIT:C125055] xref: UMLS:C0600142 xref: NCI:CTCAE:10020407 xref: NCIT:C125055 xref: NCIT:C125645 xref: NCIT:C3109 property_value: ESCORT_rule "CCTO:001089 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hot flashes'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001089 implies CCTO:001130" xsd:string ! ESCORT_rule ''Hot flashes'' implies ''Vascular disorders'' property_value: schema "CCTO:001089(time_t t0) = EVENT_STATE(CCTO:001089, t0)" xsd:string ! schema ''Hot flashes''(time_t t0) = EVENT_STATE(''Hot flashes'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001090 name: Hypertension def: "Blood pressure that is abnormally high." [NCIT:C3117] synonym: "Blood pressure, high" EXACT [NCIT:C3117] synonym: "Blood pressure, increased" EXACT [NCIT:C3117] synonym: "HTN" EXACT [NCIT:C3117] synonym: "High blood pressure" EXACT [NCIT:C3117] synonym: "Hypertension adverse event" EXACT [NCIT:C55060] synonym: "Increased blood pressure" EXACT [NCIT:C3117] synonym: "Pressure, high blood" EXACT [NCIT:C3117] synonym: "Vascular hypertensive disorder" EXACT [NCIT:C3117] xref: UMLS:C0020538 xref: UMLS:C1963138 xref: UMLS:C0497247 xref: UMLS:C2917273 xref: NCI:CTCAE:10020772 xref: NCIT:C3117 xref: NCIT:C55060 property_value: ESCORT_rule "CCTO:001090 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypertension'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001090 implies CCTO:001130" xsd:string ! ESCORT_rule ''Hypertension'' implies ''Vascular disorders'' property_value: schema "CCTO:001090(time_t t0) = EVENT_STATE(CCTO:001090, t0)" xsd:string ! schema ''Hypertension''(time_t t0) = EVENT_STATE(''Hypertension'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001091 name: Hypotension def: "Blood pressure that is abnormally low OR A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment." [NCIT:C3128, NCI:CTCAE] synonym: "Blood pressure, decreased" EXACT [NCIT:C3128] synonym: "Blood pressure, low" EXACT [NCIT:C3128] synonym: "Decreased blood pressure" EXACT [NCIT:C3128] synonym: "Hypotension adverse event" EXACT [NCIT:C55061] synonym: "Low blood pressure" EXACT [NCIT:C3128] synonym: "Pressure, low blood" EXACT [NCIT:C3128] synonym: "Vascular hypotensive disorder" EXACT [NCIT:C3128] xref: UMLS:C0020649 xref: UMLS:C3163620 xref: UMLS:C2917141 xref: NCI:CTCAE:10021097 xref: NCIT:C3128 xref: NCIT:C55061 property_value: ESCORT_rule "CCTO:001091 implies CCTO:000049" xsd:string ! ESCORT_rule ''Hypotension'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001091 implies CCTO:001130" xsd:string ! ESCORT_rule ''Hypotension'' implies ''Vascular disorders'' property_value: schema "CCTO:001091(time_t t0) = EVENT_STATE(CCTO:001091, t0)" xsd:string ! schema ''Hypotension''(time_t t0) = EVENT_STATE(''Hypotension'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001092 name: Lymph leakage def: "The loss of lymph into the surrounding tissue or body cavity OR A disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity." [NCIT:C78439, NCI:CTCAE] xref: UMLS:C0398372 xref: NCI:CTCAE:10065773 xref: NCIT:C78439 property_value: ESCORT_rule "CCTO:001092 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lymph leakage'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001092 implies CCTO:001130" xsd:string ! ESCORT_rule ''Lymph leakage'' implies ''Vascular disorders'' property_value: schema "CCTO:001092(time_t t0) = EVENT_STATE(CCTO:001092, t0)" xsd:string ! schema ''Lymph leakage''(time_t t0) = EVENT_STATE(''Lymph leakage'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001093 name: Lymphedema def: "A disorder characterized by excessive fluid collection in tissues that causes swelling OR Excess fluid collection in tissues, causing swelling. It is the result of obstruction of lymphatic vessels or lymph nodes." [NCI:CTCAE, NCIT:C3207] xref: UMLS:C0024236 xref: NCI:CTCAE:10025233 xref: NCIT:C3207 property_value: ESCORT_rule "CCTO:001093 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lymphedema'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001093 implies CCTO:001130" xsd:string ! ESCORT_rule ''Lymphedema'' implies ''Vascular disorders'' property_value: schema "CCTO:001093(time_t t0) = EVENT_STATE(CCTO:001093, t0)" xsd:string ! schema ''Lymphedema''(time_t t0) = EVENT_STATE(''Lymphedema'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001094 name: Lymphocele def: "A cystic lesion containing lymph. It usually results from injury, gynecologic surgery, or urologic surgery OR A disorder characterized by a cystic lesion containing lymph OR An adverse event characterized by a cystic lesion containing lymph." [NCIT:C78442, NCI:CTCAE, NCIT:C55705] synonym: "Lymphocele adverse event" EXACT [NCIT:C55705] xref: UMLS:C1963162 xref: UMLS:C0024248 xref: NCI:CTCAE:10048642 xref: NCIT:C55705 xref: NCIT:C78442 property_value: ESCORT_rule "CCTO:001094 implies CCTO:000049" xsd:string ! ESCORT_rule ''Lymphocele'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001094 implies CCTO:001130" xsd:string ! ESCORT_rule ''Lymphocele'' implies ''Vascular disorders'' property_value: schema "CCTO:001094(time_t t0) = EVENT_STATE(CCTO:001094, t0)" xsd:string ! schema ''Lymphocele''(time_t t0) = EVENT_STATE(''Lymphocele'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001095 name: Peripheral ischemia def: "A disorder characterized by impaired circulation to an extremity OR Deficient blood distribution to the limbs caused by narrowing or obstruction of the lumen of the peripheral arteries." [NCI:CTCAE, NCIT:C78535] xref: UMLS:C0235490 xref: NCI:CTCAE:10034578 xref: NCIT:C78535 property_value: ESCORT_rule "CCTO:001095 implies CCTO:000049" xsd:string ! ESCORT_rule ''Peripheral ischemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001095 implies CCTO:001130" xsd:string ! ESCORT_rule ''Peripheral ischemia'' implies ''Vascular disorders'' property_value: schema "CCTO:001095(time_t t0) = EVENT_STATE(CCTO:001095, t0)" xsd:string ! schema ''Peripheral ischemia''(time_t t0) = EVENT_STATE(''Peripheral ischemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001096 name: Phlebitis def: "Inflammation of a vein OR A disorder characterized by inflammation of the wall of a vein." [NCIT:C38003, NCI:CTCAE] xref: UMLS:C0031542 xref: NCI:CTCAE:10034879 xref: NCIT:C38003 property_value: ESCORT_rule "CCTO:001096 implies CCTO:000049" xsd:string ! ESCORT_rule ''Phlebitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001096 implies CCTO:001130" xsd:string ! ESCORT_rule ''Phlebitis'' implies ''Vascular disorders'' property_value: schema "CCTO:001096(time_t t0) = EVENT_STATE(CCTO:001096, t0)" xsd:string ! schema ''Phlebitis''(time_t t0) = EVENT_STATE(''Phlebitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001097 name: Superficial thrombophlebitis def: "A disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities OR Thrombosis and inflammation of a superficial vein of the extremities. Symptoms include red discoloration and warmth of the skin and pain along the affected vein." [NCI:CTCAE, NCIT:C78634] xref: UMLS:C1510431 xref: NCI:CTCAE:10042554 xref: NCIT:C78634 property_value: ESCORT_rule "CCTO:001097 implies CCTO:000049" xsd:string ! ESCORT_rule ''Superficial thrombophlebitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001097 implies CCTO:001130" xsd:string ! ESCORT_rule ''Superficial thrombophlebitis'' implies ''Vascular disorders'' property_value: schema "CCTO:001097(time_t t0) = EVENT_STATE(CCTO:001097, t0)" xsd:string ! schema ''Superficial thrombophlebitis''(time_t t0) = EVENT_STATE(''Superficial thrombophlebitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001098 name: Superior vena cava syndrome def: "A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache OR Obstruction of the blood flow in the superior vena cava caused by a malignant neoplasm, thrombosis, or aneurysm. It is a medical emergency requiring immediate treatment. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea, and headache." [NCI:CTCAE, NCIT:C3396] xref: UMLS:C0038833 xref: NCI:CTCAE:10042569 xref: NCIT:C3396 property_value: ESCORT_rule "CCTO:001098 implies CCTO:000049" xsd:string ! ESCORT_rule ''Superior vena cava syndrome'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001098 implies CCTO:001130" xsd:string ! ESCORT_rule ''Superior vena cava syndrome'' implies ''Vascular disorders'' property_value: schema "CCTO:001098(time_t t0) = EVENT_STATE(CCTO:001098, t0)" xsd:string ! schema ''Superior vena cava syndrome''(time_t t0) = EVENT_STATE(''Superior vena cava syndrome'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001099 name: Thromboembolic event def: "Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream OR A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream." [NCIT:C28195, NCI:CTCAE] synonym: "Thromboembolism" EXACT [NCIT:C28195] xref: UMLS:C0040038 xref: UMLS:C0857496 xref: NCI:CTCAE:10043565 xref: NCIT:C28195 property_value: ESCORT_rule "CCTO:001099 implies CCTO:000049" xsd:string ! ESCORT_rule ''Thromboembolic event'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001099 implies CCTO:001130" xsd:string ! ESCORT_rule ''Thromboembolic event'' implies ''Vascular disorders'' property_value: schema "CCTO:001099(time_t t0) = EVENT_STATE(CCTO:001099, t0)" xsd:string ! schema ''Thromboembolic event''(time_t t0) = EVENT_STATE(''Thromboembolic event'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001100 name: Vasculitis def: "An inflammatory process involving the wall of the vessels (large, medium, or small-sized vessels). The inflammatory process may cause necrosis or formation of granulomas in the vascular wall. It may be the result of an autoimmune disorder, infection, or malignancy. Representative examples include polyarteritis nodosa, temporal arteritis, Wegener granulomatosis, Kawasaki disease, Takayasu arteritis, and Henoch-Schonlein purpura OR A disorder characterized by inflammation involving the wall of a vessel." [NCIT:C26912, NCI:CTCAE] synonym: "Vasculitis adverse event" EXACT [NCIT:C54741] xref: UMLS:C0042384 xref: UMLS:C1963274 xref: NCI:CTCAE:10047115 xref: NCIT:C26912 xref: NCIT:C54741 property_value: ESCORT_rule "CCTO:001100 implies CCTO:000049" xsd:string ! ESCORT_rule ''Vasculitis'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001100 implies CCTO:001130" xsd:string ! ESCORT_rule ''Vasculitis'' implies ''Vascular disorders'' property_value: schema "CCTO:001100(time_t t0) = EVENT_STATE(CCTO:001100, t0)" xsd:string ! schema ''Vasculitis''(time_t t0) = EVENT_STATE(''Vasculitis'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001101 name: Visceral arterial ischemia def: "A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery OR Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool." [NCI:CTCAE, NCIT:C78712] synonym: "Mesenteric artery ischemia" EXACT [NCIT:C78712] synonym: "Visceral artery ischemia" EXACT [NCIT:C78712] xref: UMLS:C0853812 xref: NCI:CTCAE:10054692 xref: NCIT:C78712 property_value: ESCORT_rule "CCTO:001101 implies CCTO:000049" xsd:string ! ESCORT_rule ''Visceral arterial ischemia'' implies ''Adverse events'' property_value: ESCORT_rule "CCTO:001101 implies CCTO:001130" xsd:string ! ESCORT_rule ''Visceral arterial ischemia'' implies ''Vascular disorders'' property_value: schema "CCTO:001101(time_t t0) = EVENT_STATE(CCTO:001101, t0)" xsd:string ! schema ''Visceral arterial ischemia''(time_t t0) = EVENT_STATE(''Visceral arterial ischemia'', t0) is_a: CCTO:000049 ! Adverse events is_a: CCTO:001130 ! Vascular disorders relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state relationship: CCTO:000009 CCTO:000347 ! is_assessed_by National Cancer Institute Common Terminology Criteria for Adverse Events [Term] id: CCTO:001102 name: Disease-specific death property_value: ESCORT_rule "CCTO:001102 implies CCTO:000114" xsd:string ! ESCORT_rule ''Disease-specific death'' implies ''Death'' is_a: CCTO:000114 ! Death relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001103 name: General disorders and administration site conditions is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001104 name: Regional recurrence property_value: ESCORT_rule "CCTO:001104 implies CCTO:000057" xsd:string ! ESCORT_rule ''Regional recurrence'' implies ''Has regional disease'' property_value: ESCORT_rule "CCTO:001104 implies CCTO:000087" xsd:string ! ESCORT_rule ''Regional recurrence'' implies ''Recurrence'' property_value: ESCORT_rule "CCTO:001104 implies CCTO:001131 " xsd:string ! ESCORT_rule ''Regional recurrence'' implies ''Locoregional recurrence'' property_value: ESCORT_rule "CCTO:001104 implies NOT CCTO:001133" xsd:string ! ESCORT_rule ''Regional recurrence'' implies NOT ''Regional control'' is_a: CCTO:000087 ! Recurrence disjoint_from: CCTO:001133 ! Regional control relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001105 name: Psychiatric disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0004936 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001106 name: Prostate cancer-specific death property_value: ESCORT_rule "CCTO:001106 implies CCTO:000114" xsd:string ! ESCORT_rule ''Prostate cancer-specific death'' implies ''Death'' is_a: CCTO:000114 ! Death relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001107 name: Tumor marker increased synonym: "Biochemical disease" [] is_a: CCTO:000006 ! Event state [Term] id: CCTO:001108 name: Gastrointestinal disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0017178 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001109 name: Musculoskeletal and connective tissue disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0263660 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001110 name: Breast cancer specific death property_value: ESCORT_rule "CCTO:001110 implies CCTO:000114" xsd:string ! ESCORT_rule ''Breast cancer specific death'' implies ''Death'' is_a: CCTO:000114 ! Death relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001111 name: Biological progression is_a: CCTO:000031 ! Measure of efficacy relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001112 name: Blood and lymphatic system disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0851353 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001113 name: Cardiac disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0018799 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001114 name: Ear and labyrinth disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0851354 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001115 name: Endocrine disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0014130 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001116 name: Eye disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0015397 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001117 name: Hepatobiliary disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0267792 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001118 name: Immune system disorders is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001119 name: Infections and infestations is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001120 name: Injury, poisoning and procedural complications property_value: ESCORT_rule "CCTO:001120 implies CCTO:000043" xsd:string ! ESCORT_rule ''Injury, poisoning and procedural complications'' implies ''Measure of safety'' is_a: CCTO:000043 ! Measure of safety relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001121 name: Metabolism and nutrition disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0851358 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001122 name: Neoplasms benign, malignant and unspecified (incl cysts and polyps) is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001123 name: Nervous system disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0027765 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001124 name: Pregnancy, puerperium and perinatal conditions is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0851363 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001125 name: Renal and urinary disorders is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001126 name: Reproductive system and breast disorders is_a: CCTO:000017 ! Physical health-related concept relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001127 name: Respiratory, thoracic and mediastinal disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0851355 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001128 name: Skin and subcutaneous tissue disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0178298 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001129 name: Social circumstances is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0851364 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001130 name: Vascular disorders is_a: CCTO:000017 ! Physical health-related concept xref: UMLS:C0042373 relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state [Term] id: CCTO:001131 name: Locoregional recurrence property_value: ESCORT_rule "CCTO:001131 implies CCTO:000211" xsd:string ! ESCORT_rule ''Locoregional recurrence'' implies ''Locoregional failure'' property_value: ESCORT_rule "CCTO:001131 implies NOT CCTO:000171" xsd:string ! ESCORT_rule ''Locoregional recurrence'' implies NOT ''Local-regional control'' is_a: CCTO:000087 ! Recurrence disjoint_from: CCTO:000171 ! Local-regional control [Term] id: CCTO:001132 name: Anthropometry is_a: CCTO:000051 ! Investigation xref: UMLS:C0003188 [Term] id: CCTO:001133 name: Regional control synonym: "Regional tumor control" [] property_value: ESCORT_rule "CCTO:001133 implies NOT CCTO:001104" xsd:string ! ESCORT_rule ''Regional control'' implies NOT ''Regional recurrence'' is_a: CCTO:000006 ! Event state is_a: CCTO:000031 ! Measure of efficacy disjoint_from: CCTO:001104 ! Regional recurrence relationship: CCTO:000008 CCTO:000006 ! has_value_type Event state