format-version: 1.2 date: 04:11:2010 08:23 saved-by: tmeehan auto-generated-by: OBO-Edit 2.1-beta1 default-namespace: cell idspace: BFO http://purl.obolibrary.org/obo/BFO_ remark: remark: $Revision: 1.48 $ See PMID:15693950, PMID:12799354, PMID:20123131, Contact Alexander Diehl, adiehl@informatics.jax.org, The Jackson Laboratory. treat-xrefs-as-equivalent: CARO treat-xrefs-as-equivalent: CL ontology: CL-edit [Term] id: CL:0000000 name: cell def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] xref: FMA:68646 [Term] id: CL:0000001 name: primary cell line cell is_a: CL:0000010 ! cell line cell [Term] id: CL:0000002 name: permanent cell line cell is_a: CL:0000010 ! cell line cell [Term] id: CL:0000003 name: cell in vivo is_a: CL:0000000 ! cell [Term] id: CL:0000004 name: cell by organism def: "A classification of cells by the organisms within which they are contained." [FB:ma] is_a: CL:0000003 ! cell in vivo [Term] id: CL:0000005 name: fibroblast neural crest derived is_a: CL:0000057 ! fibroblast relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell (sensu Animalia) is_a: CL:0000197 ! receptor cell is_a: CL:0000540 ! neuron [Term] id: CL:0000007 name: early embryonic cell def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000008 name: cranial neural crest cell is_a: CL:0000333 ! neural crest cell [Term] id: CL:0000009 name: fusiform initial alt_id: CL:0000274 def: "An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208] synonym: "xylem initial" RELATED [] synonym: "xylem mother cell" RELATED [] is_a: CL:0000272 ! cambial initial is_a: CL:0000610 ! plant cell [Term] id: CL:0000010 name: cell line cell is_a: CL:0000578 ! experimentally modified cell [Term] id: CL:0000011 name: trunk neural crest cell is_a: CL:0000333 ! neural crest cell [Term] id: CL:0000012 name: cell by class is_a: CL:0000003 ! cell in vivo [Term] id: CL:0000013 name: dentine secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000014 name: germ line stem cell synonym: "germline stem cell" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:0000039 ! germ line cell [Term] id: CL:0000015 name: male germ cell xref: FMA:72290 is_a: CL:0000586 ! germ cell [Term] id: CL:0000016 name: male germ line stem cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A.05.360.490.890.880] xref: FBbt:00004936 xref: FMA:84049 is_a: CL:0000015 ! male germ cell relationship: develops_from CL:0000020 ! spermatogonium [Term] id: CL:0000018 name: spermatid def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A.05.360.490.890.860] synonym: "Nematoblast" EXACT [] xref: FBbt:00004942 xref: FMA:72294 is_a: CL:0000015 ! male germ cell is_a: CL:0000413 ! haploid cell relationship: develops_from CL:0000657 ! secondary spermatocyte [Term] id: CL:0000019 name: sperm def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A.05.360.490.890] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] xref: FBbt:00004954 xref: FMA:67338 is_a: CL:0000219 ! motile cell is_a: CL:0000408 ! male gamete relationship: develops_from CL:0000018 ! spermatid [Term] id: CL:0000020 name: spermatogonium def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A.05.360.490.890.900] xref: FBbt:00004935 xref: FMA:72291 is_a: CL:0000015 ! male germ cell is_a: CL:0000414 ! cell by ploidy [Term] id: CL:0000021 name: female germ cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] is_a: CL:0000586 ! germ cell [Term] id: CL:0000022 name: female germ line stem cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000021 ! female germ cell [Term] id: CL:0000023 name: oocyte def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] xref: FBbt:00004886 xref: FMA:18644 is_a: CL:0000021 ! female germ cell [Term] id: CL:0000024 name: oogonial cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] xref: FMA:83673 is_a: CL:0000021 ! female germ cell relationship: develops_from CL:0000670 ! primordial germ cell [Term] id: CL:0000025 name: egg def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: FBbt:00000034 xref: FMA:67343 is_a: CL:0000023 ! oocyte is_a: CL:0000675 ! female gamete relationship: develops_from CL:0000655 ! secondary oocyte [Term] id: CL:0000026 name: invertebrate nurse cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391] synonym: "nurse cell" RELATED [] xref: FBbt:00004878 is_a: CL:0000039 ! germ line cell is_a: CL:0000412 ! polyploid cell relationship: develops_from CL:0000722 ! cystoblast [Term] id: CL:0000027 name: smooth muscle cell neural crest derived is_a: CL:0000192 ! smooth muscle cell relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000028 name: CNS neuron (sensu Nematoda and Protostomia) is_a: CL:0000540 ! neuron relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000029 name: neuron neural crest derived is_a: CL:0000540 ! neuron relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000030 name: glioblast xref: FBbt:00005145 is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000031 name: neuroblast xref: FBbt:00005146 xref: FMA:70563 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000032 name: neuroplacodal cell def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256] synonym: "neural placode cell" EXACT [] is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000033 name: apocrine cell def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000034 name: stem cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A.11.872] xref: FMA:63368 is_a: CL:0000144 ! cell by function [Term] id: CL:0000035 name: single fate stem cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] synonym: "Unipotent stem cell" EXACT [] synonym: "Unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000036 name: epithelial fate stem cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000037 name: hematopoietic stem cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4,CD5,CD8 alpha chain, CD14, CD19, CD20, integrin alpha-M, neural cell adhesion molecule 1, lymphocyte antigen 6G, lymphocyte antigen 76." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" EXACT [] xref: FMA:70337 xref: FMA:86475 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000988 ! hematopoietic cell relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell [Term] id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell [Term] id: CL:0000039 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children is_a: CL:0000144 ! cell by function is_a: CL:0000548 ! animal cell [Term] id: CL:0000040 name: monoblast def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://www.clt.astate.edu/wwilliam/, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. synonym: "CFU-M" RELATED [] synonym: "colony forming unit macrophage" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: FMA:83553 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor [Term] id: CL:0000041 name: mature eosinophil def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000771 ! eosinophil relationship: develops_from CL:0000774 ! band form eosinophil [Term] id: CL:0000042 name: neutrophilic myeloblast def: "A myeloblast committed to the neutrophil lineage." [GOC:add, ISBN:0721601464] synonym: "neutrophilic granuloblast" RELATED [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 ! myeloblast relationship: develops_from CL:0000834 ! neutrophil progenitor cell [Term] id: CL:0000043 name: mature basophil alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-25, CCL22, tslp, vegf, and LTC4. synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000767 ! basophil is_a: CL:0002274 ! histamine secreting cell relationship: develops_from CL:0000770 ! band form basophil [Term] id: CL:0000045 name: thymus processed stem cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. is_obsolete: true [Term] id: CL:0000046 name: bursa processed stem cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816' or one of its children instead. is_obsolete: true [Term] id: CL:0000047 name: neuronal stem cell def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [GOC:tfm, PMID:15247488] xref: FMA:86684 is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000048 name: multi fate stem cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "Multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000049 name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata-1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, MESH:D023461, PMID:10724173, PMID:15955840] synonym: "cfu-gemm" RELATED [ISBN:0878932437] synonym: "CFU-S" RELATED [ISBN:0878932437] synonym: "CMP" EXACT [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:tfm] synonym: "CFU-EM" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000051 name: common lymphoid progenitor alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:tfm, PMID:10407577] synonym: "CLP" EXACT [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell [Term] id: CL:0000052 name: totipotent stem cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "Totipotential stem cell" EXACT [] xref: FMA:84790 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000053 name: enamel secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000054 name: bone matrix secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000055 name: non-terminally differentiated cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] synonym: "blast cell" EXACT [] xref: FMA:84782 is_a: CL:0000012 ! cell by class [Term] id: CL:0000056 name: myoblast def: "An embryonic (precursor) cell of the myogenic lineage that develops from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes." [GOC:tfm, MESH:A.11.635] xref: FBbt:00005083 xref: FMA:70335 is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000355 ! muscle stem cell [Term] id: CL:0000057 name: fibroblast def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://63.198.234.228/OpenFMA/Fibroblast.html, ISBN:0517223651, MESH:A.11.329.228] xref: FMA:63877 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000058 name: chondroblast def: "An immature cartilage-producing cell found in growing cartilage." [GOC:tfm, ISBN:0618947256] synonym: "chrondoplast" EXACT [] xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000059 name: ameloblast def: "A cylindrical epithelial cell in the innermost layer of the enamel organ. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the dental enamel), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)." [GOC:tfm, MESH:A.11.436.107] xref: FMA:70576 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002159 ! general ecto-epithelial cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000060 name: odontoblast def: "One of the cells forming the outer surface of dental pulp that produces tooth dentin." [ISBN:0618947256] xref: FMA:62999 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002159 ! general ecto-epithelial cell relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000061 name: cementoblast def: "A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth." [ISBN:0781733901 "Stedman's Medical Dictionary"] xref: FMA:63002 is_a: CL:0000062 ! osteoblast [Term] id: CL:0000062 name: osteoblast def: "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [MESH:A.11.329.629] xref: FMA:66780 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000008 ! cranial neural crest cell relationship: develops_from CL:0000375 ! osteoprogenitor cell [Term] id: CL:0000063 name: cell by histology def: "A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm] is_a: CL:0000012 ! cell by class [Term] id: CL:0000064 name: ciliated cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] is_a: CL:0000063 ! cell by histology [Term] id: CL:0000065 name: ependymal cell def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134] synonym: "ependymocyte" EXACT [] xref: FMA:70550 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000066 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A.11.436] synonym: "Epitheliocyte" EXACT [] xref: FBbt:00000124 xref: FMA:66768 is_a: CL:0000063 ! cell by histology is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000067 name: ciliated epithelial cell def: "An epithelial cell that has a cillia." [GOC:tfm] xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000068 name: duct epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000069 name: branched duct epithelial cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000070 name: epithelial cell of gland is_obsolete: true [Term] id: CL:0000071 name: blood vessel endothelial cell def: "The endothelial cells that line the vasculature." [GOC:tfm] synonym: "Cuboidal endothelial cell of vascular tree" EXACT [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002139 ! endothelial cell of vascular tree relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000072 name: non-branched duct epithelial cell is_a: CL:0000068 ! duct epithelial cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000073 name: barrier epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000074 name: epithem cell def: "A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305] is_a: CL:0000151 ! secretory cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000076 name: squamous epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] synonym: "Mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000078 name: peridermal cell is_a: CL:0000076 ! squamous epithelial cell [Term] id: CL:0000079 name: stratified epithelial cell is_a: CL:0000066 ! epithelial cell relationship: develops_from CL:0000357 ! stratified epithelial stem cell [Term] id: CL:0000080 name: circulating cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000144 ! cell by function [Term] id: CL:0000081 name: blood cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] xref: fma:62844 is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0000082 name: epithelial cell of lung is_a: CL:0000066 ! epithelial cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000083 name: epithelial cell of pancreas def: "An epithelial cell of the pancreas." [GOC:tfm] synonym: "epithelial cell of exocrine pancreas" NARROW [] synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000066 ! epithelial cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000084 name: T cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: FMA:62870 is_a: CL:0000542 ! lymphocyte disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: develops_from CL:0000827 ! pro-T cell [Term] id: CL:0000085 name: germ line stem cell (sensu Vertebrata) is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000086 name: germ line stem cell (sensu Nematoda and Protostomia) xref: FBbt:00004861 is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000087 name: male germ line stem cell (sensu Nematoda and Protostomia) xref: FBbt:00004929 is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000088 name: female germ line stem cell (sensu Nematoda and Protostomia) xref: FBbt:00004873 is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000089 name: male germ line stem cell (sensu Vertebrata) is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000090 name: female germ line stem cell (sensu Vertebrata) is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000091 name: Kupffer cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A.11.329.372.588, PMID:15771589, PMID:17105582] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythro-cytes, iron metabolism. synonym: "Hepatic macrophage" EXACT [] synonym: "Hepatic stellate cell" EXACT [] synonym: "Littoral cell of hepatic sinusoid" EXACT [] synonym: "Macrophagocytus stellatus" EXACT [] synonym: "Stellate cell of von Kupffer" EXACT [] synonym: "Von Kupffer cell" EXACT [] xref: FMA:14656 is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000092 name: osteoclast def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: FMA:66781 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000576 ! monocyte [Term] id: CL:0000093 name: osteochondroclast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using 'osteoclast ; CL:0000092' instead. is_obsolete: true [Term] id: CL:0000094 name: granulocyte def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, MESH:A.11.118.637.415] synonym: "Granular leucocyte" EXACT [] synonym: "Granular leukocyte" EXACT [] xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000095 name: neuron associated cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000096 name: mature neutrophil def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:tfm, http://www.cap.org, MESH:A.11.118.637.415.583] synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] is_a: CL:0000775 ! neutrophil relationship: develops_from CL:0000560 ! band form neutrophil [Term] id: CL:0000097 name: mast cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A.11.329.427, PMID:15153310, PMID:16330751, PMID:16455980, PMID:18483499, PMID:19671378, PMID:9354811 MESH\:D008407] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors GATA-1 and MITF. synonym: "Histaminocyte" EXACT [] synonym: "labrocyte" EXACT [ISBN:0721601464] synonym: "mastocyte" EXACT [ISBN:0721601464] synonym: "tissue basophil" RELATED [ISBN:068340007X] xref: FMA:66784 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell relationship: develops_from CL:0000831 ! mast cell progenitor [Term] id: CL:0000098 name: sensory epithelial cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] is_a: CL:0000197 ! receptor cell [Term] id: CL:0000099 name: interneuron def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A.08.663.358] xref: FBbt:00005125 xref: FMA:67313 is_a: CL:0000540 ! neuron [Term] id: CL:0000100 name: motor neuron def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [MESH:A.08.663.655.500, PMID:16875686] synonym: "anterior horn cell" EXACT [] synonym: "motoneuron" EXACT [] xref: FMA:83617 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000101 name: sensory neuron def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] xref: FBbt:00005124 xref: FMA:84649 is_a: CL:0000526 ! afferent neuron [Term] id: CL:0000102 name: polymodal neuron is_a: CL:0000540 ! neuron [Term] id: CL:0000103 name: bipolar neuron def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442] xref: FMA:67282 is_a: CL:0000063 ! cell by histology is_a: CL:0000099 ! interneuron [Term] id: CL:0000104 name: multipolar neuron def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm] is_a: CL:0000540 ! neuron [Term] id: CL:0000105 name: pseudounipolar neuron def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm] is_a: CL:0000540 ! neuron [Term] id: CL:0000106 name: unipolar neuron def: "Neuron with an axon and no dendrites." [FMA:67278] is_a: CL:0000540 ! neuron [Term] id: CL:0000107 name: autonomic neuron def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:0000029 ! neuron neural crest derived [Term] id: CL:0000108 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: FMA:84796 xref: WBbt:0006840 is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000109 name: adrenergic neuron is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000110 name: peptidergic neuron is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000111 name: peripheral neuron def: "A neuron that is part of nerve found outside the central nervous system." [ISBN:0721662544] xref: FMA:84664 is_a: CL:0000029 ! neuron neural crest derived [Term] id: CL:0000112 name: columnar neuron synonym: "columnar neuron" RELATED [] is_a: CL:0000540 ! neuron [Term] id: CL:0000113 name: mononuclear phagocyte def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] is_a: CL:0000224 ! cell by nuclear number is_a: CL:0000518 ! phagocyte (sensu Vertebrata) [Term] id: CL:0000114 name: surface ectodermal cell synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000115 name: endothelial cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://63.198.234.228/OpenFMA/Endothelial cell.html] comment: From FMA: \n9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classifiaction is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard] synonym: "Endotheliocyte" EXACT [] xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000116 name: pioneer neuron xref: FBbt:00005128 is_a: CL:0000540 ! neuron [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) is_a: CL:0000540 ! neuron relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000118 name: basket cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000119 name: Golgi cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000120 name: granule cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000121 name: Purkinje cell def: "The output neuron of the cerebellar cortex." [MESH:A.08.186.211.132.810.428.200.212.600] synonym: "Purkinje neuron" EXACT [] synonym: "Purkinje's cell" EXACT [] xref: FMA:67969 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000122 name: stellate cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000124 name: glial cell (sensu Nematoda and Protostomia) xref: FBbt:00005144 is_a: CL:0000125 ! glial cell is_a: CL:0000340 ! glioblast (sensu Nematoda and Protostomia) [Term] id: CL:0000125 name: glial cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A.08.637] synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000030 ! glioblast [Term] id: CL:0000126 name: macroglial cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] synonym: "Macrogliocyte" EXACT [] xref: FMA:54538 is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [MESH:A.08.637.200] xref: FMA:54537 is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [MESH:A.08.637.600] synonym: "oligodendroglia" RELATED [] xref: FMA:54540 is_a: CL:0000126 ! macroglial cell relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000129 name: microglial cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19461673] comment: Markers: Mouse: CD11b+, F4/80+, CD68+. synonym: "microglia" EXACT [] xref: FMA:54539 is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000130 name: neuron associated cell (sensu Nematoda and Protostomia) is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000131 name: gut endothelial cell is_a: CL:0000115 ! endothelial cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000132 name: corneal endothelial cell def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [GOC:tfm, MESH:A.09.371.060.067.31] xref: FMA:70614 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000133 name: neurectodermal cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal cell def: "A cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [FB:ma] xref: FMA:70546 is_a: CL:0000063 ! cell by histology relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000135 name: fibrocyte def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] xref: FMA:63879 is_a: CL:0000499 ! stromal cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000057 ! fibroblast [Term] id: CL:0000136 name: fat cell alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A.11.329.114] synonym: "adipocyte" EXACT [] synonym: "adipose cell" EXACT [] xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000137 name: osteocyte def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A.11.329.629.500] synonym: "bone cell" EXACT [] xref: FMA:66779 is_a: CL:0000054 ! bone matrix secreting cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000062 ! osteoblast [Term] id: CL:0000138 name: chondrocyte def: "Polymorphic cell that form cartilage." [MESH:A.11.329.171] synonym: "cartilage cell" EXACT [] xref: FMA:66782 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000667 ! collagen secreting cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000058 ! chondroblast [Term] id: CL:0000139 name: amelocyte is_a: CL:0000053 ! enamel secreting cell is_a: CL:0000146 ! simple columnar epithelial cell relationship: develops_from CL:0000059 ! ameloblast [Term] id: CL:0000140 name: odontocyte is_a: CL:0000013 ! dentine secreting cell relationship: develops_from CL:0000060 ! odontoblast relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000141 name: cementocyte def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901 "Stedman's Medical Dictionary"] xref: FMA:63003 is_a: CL:0000137 ! osteocyte relationship: develops_from CL:0000061 ! cementoblast [Term] id: CL:0000142 name: hyalocyte def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178] synonym: "vitreous cell" RELATED [] xref: FMA:70620 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000143 name: guidepost cell is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000144 name: cell by function def: "A classification of cells by their primary end goal or behavior." [FB:ma] is_a: CL:0000012 ! cell by class [Term] id: CL:0000145 name: professional antigen presenting cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constituitively express MHC Class II as well as constimulatory molecules, and thus can initiate immune responses via T cells. synonym: "APC" BROAD [] is_a: CL:0000473 ! defensive cell [Term] id: CL:0000146 name: simple columnar epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000147 name: pigment cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000148 name: melanocyte alt_id: CL:0000572 def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl] synonym: "melanophore" NARROW [] xref: FMA:70545 is_a: CL:0000147 ! pigment cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000541 ! melanoblast [Term] id: CL:0000149 name: visual pigment cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] xref: FMA:86494 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000151 name: secretory cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] xref: FMA:86916 is_a: CL:0000144 ! cell by function [Term] id: CL:0000152 name: exocrine cell def: "A cell of an exocrine gland, i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] xref: FMA:16014 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000153 name: GAG secreting cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] synonym: "hyaluronic acid secreting cell" EXACT [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000155 name: pepsinogen secreting cell def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [GOC:tfm] synonym: "chief cell of stomach" EXACT [] synonym: "peptic cell" EXACT [] synonym: "zymogenic cell" EXACT [] xref: FMA:62902 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002178 ! epithelial cell of stomach [Term] id: CL:0000156 name: antibody secreting cell def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." [] comment: Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000157 name: surfactant secreting cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000158 name: Clara cell def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [GOC:tfm, PMID:12107102, PMID:7905712] synonym: "Bronchiolar non-ciliated " EXACT [] synonym: "Clara cell" EXACT [] synonym: "Clara cell of bronchiole" EXACT [] xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002328 ! bronchial epithelial cell [Term] id: CL:0000159 name: seromucus secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A.03.492.411.369.320] synonym: "chalice cell" EXACT [] xref: FMA:13148 is_a: CL:0000319 ! mucus secreting cell [Term] id: CL:0000161 name: acid secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000162 name: parietal cell def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [GOC:tfm, ISBN:0517223651] synonym: "oxyntic cell" EXACT [] xref: FMA:62901 is_a: CL:0000161 ! acid secreting cell is_a: CL:0002178 ! epithelial cell of stomach [Term] id: CL:0000163 name: endocrine cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A.06.407] synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000164 name: enteroendocrine cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] xref: FMA:62930 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell def: "A neuron that has the specialized function to produce and secrete hormones, and that constitutes, in whole or in part, an endocrine organ or system." [MESH:A.06.688] synonym: "neurosecretory cell" EXACT [] xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000393 ! electrically responsive cell [Term] id: CL:0000166 name: chromaffin cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A.06.224.161] synonym: "phaeochromocyte" EXACT [] xref: FMA:69263 is_a: CL:0000568 ! APUD cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000167 name: peptide hormone secreting cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000168 name: insulin secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000169 name: type B pancreatic cell def: "A cell located towards center of the islets of Langerhan's that secrete insulin." [GOC:tfm, ISBN:0517223651] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic beta cell" EXACT [] xref: FMA:70586 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000168 ! insulin secreting cell relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas [Term] id: CL:0000170 name: glucagon secreting cell def: "A cell that secretes glucagon." [GOC:tfm] synonym: "Glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000171 name: pancreatic A cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] synonym: "pancreatic alpha cell" EXACT [] xref: FMA:70585 is_a: CL:0002067 ! type A enterocrine cell relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas [Term] id: CL:0000172 name: somatostatin secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000173 name: pancreatic D cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] synonym: "D-cell of pancreatic islet" EXACT [] synonym: "Delta cell of islet" EXACT [] synonym: "Delta cell of pancreatic islet" EXACT [] synonym: "Pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "Pancreatic delta cell" EXACT [] synonym: "Somatostatin-secreting pancreatic cell" EXACT [] xref: FMA:70587 is_a: CL:0000502 ! type D enteroendocrine cell relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas [Term] id: CL:0000174 name: steroid hormone secreting cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000175 name: luteal cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A.05.360.319.114.630.278.400] synonym: "lutein cell" EXACT [] xref: FMA:18688 is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000176 name: ecdysteroid secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000177 name: testosterone secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000178 name: Leydig cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120] synonym: "interstitial cell" EXACT [] xref: FMA:72297 is_a: CL:0000177 ! testosterone secreting cell [Term] id: CL:0000179 name: progesterone secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000180 name: estradiol secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000181 name: metabolising cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000144 ! cell by function [Term] id: CL:0000182 name: hepatocyte def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, ISBN:0412046911, MESH:A.11.436.348] xref: FMA:14515 is_a: CL:0000066 ! epithelial cell is_a: CL:0000181 ! metabolising cell is_a: CL:0000417 ! endopolyploid cell relationship: develops_from CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000183 name: contractile cell def: "A cell whose primary function is to shorten." [FB:ma] is_a: CL:0000144 ! cell by function [Term] id: CL:0000185 name: myoepithelial cell def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544] synonym: "basket epithelial cell" EXACT [] synonym: "Myoepitheliocyte" EXACT [] xref: FMA:67799 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000186 name: myofibroblast cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [PMID:19800625] is_a: CL:0000183 ! contractile cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000187 name: muscle cell def: "A mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A.11.620] synonym: "myocyte" EXACT [] xref: FBbt:00005074 xref: FMA:67328 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000056 ! myoblast [Term] id: CL:0000188 name: skeletal muscle cell def: "Striated muscle cell which has as its direct parts two or more peripherally located nuclei." [GOC:tfm] synonym: "Skeletal muscle fiber" EXACT [] xref: FMA:9727 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell relationship: develops_from CL:0002372 ! myotubule [Term] id: CL:0000189 name: slow muscle cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908] synonym: "slow muscle fiber" EXACT [ISBN:0815316208] xref: FMA:84448 is_a: CL:0000188 ! skeletal muscle cell relationship: develops_from CL:0000857 ! slow muscle myoblast [Term] id: CL:0000190 name: fast muscle cell def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908] synonym: "glycolytic muscle fiber" EXACT [] is_a: CL:0000188 ! skeletal muscle cell relationship: develops_from CL:0000858 ! fast muscle myoblast [Term] id: CL:0000192 name: smooth muscle cell alt_id: CL:0000191 def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [MESH:A.11.620.520] synonym: "non-striated muscle cell" EXACT [] synonym: "smooth muscle fiber" EXACT [] xref: FMA:14072 is_a: CL:0000187 ! muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast [Term] id: CL:0000193 name: cardiac muscle cell (sensu Arthopoda) alt_id: CL:0000466 def: "A striated muscle cell found in the heart. They develop from cardiac myoblasts." [MESH:A.11.620.500] synonym: "cardiocyte" EXACT [] synonym: "heart muscle cell" EXACT [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000746 ! cardiac muscle cell relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) [Term] id: CL:0000194 name: nodal cardiac cell comment: Consider CL:0002072. is_obsolete: true [Term] id: CL:0000195 name: Purkinje fiber is_obsolete: true [Term] id: CL:0000196 name: flight muscle cell is_a: CL:0000187 ! muscle cell is_a: CL:0000228 ! multinucleate cell [Term] id: CL:0000197 name: receptor cell is_a: CL:0000144 ! cell by function [Term] id: CL:0000198 name: pain receptor cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A.08.800.550.700.650] synonym: "nociceptor" EXACT [] synonym: "nocireceptor" EXACT [] is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000199 name: mechanoreceptor cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A.08.800.550.700.500] is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000200 name: touch receptor cell is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000202 name: auditory hair cell alt_id: CL:0000201 def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A.08.663.650.250] comment: In mammals these cells are located in the organ of Corti. synonym: "auditory receptor cell" EXACT [] synonym: "cochlear hair cell" EXACT [] xref: FMA:62364 is_a: CL:0002374 ! inner ear hair cell [Term] id: CL:0000203 name: gravity sensitive cell is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000204 name: acceleration receptive cell is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000205 name: thermoreceptor cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [MESH:A.08.800.550.700.840] is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000206 name: chemoreceptor cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A.08.800.550.700.120] is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000207 name: olfactory receptor cell synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: FMA:67860 is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000208 name: pH receptor cell is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000209 name: taste receptor cell def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [GOC:tfm, ISBN:0618947256] synonym: "taste bud cell" EXACT [] xref: FMA:67910 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0002076 ! endo-epithelial cell [Term] id: CL:0000210 name: photoreceptor cell def: "A cell specialized to detect and transduce light." [MESH:A.08.663.650.650] xref: FBbt:00004211 xref: FMA:86740 is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000211 name: electrically active cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000144 ! cell by function [Term] id: CL:0000212 name: absorptive cell def: "A cell that takes up and metabolizes substances." [CL:CVS] is_a: CL:0000144 ! cell by function [Term] id: CL:0000213 name: lining cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474] synonym: "Hyaluronic acid secreting cell" EXACT [] synonym: "Synoviocyte" EXACT [] xref: FMA:66786 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000215 name: barrier cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000144 ! cell by function [Term] id: CL:0000216 name: Sertoli cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A.05.360.444.849.789] xref: FMA:72298 is_a: CL:0000215 ! barrier cell is_a: CL:0000511 ! androgen binding protein secreting cell [Term] id: CL:0000217 name: insulating cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A.08.637.800] synonym: "Neurilemmal cell" EXACT [] synonym: "Peripheral neuroglial cell" BROAD [] xref: FMA:62121 is_a: CL:0000217 ! insulating cell is_a: CL:0000243 ! glial cell (sensu Vertebrata) is_a: CL:0000328 ! myelin accumulating cell relationship: develops_from CL:0002377 ! immature Schwann cell [Term] id: CL:0000219 name: motile cell def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000144 ! cell by function [Term] id: CL:0000220 name: cell by lineage is_a: CL:0000012 ! cell by class [Term] id: CL:0000221 name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:A.16.254.425.273] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0000220 ! cell by lineage is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000222 name: mesodermal cell def: "A cell of the middle germ layer of the embryo." [MESH:A.16.254.425.660] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CL:0000220 ! cell by lineage is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000223 name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:A.16.254.425.407] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0000220 ! cell by lineage is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000224 name: cell by nuclear number def: "A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm] is_a: CL:0000012 ! cell by class [Term] id: CL:0000225 name: anucleate cell def: "A cell that lacks a nucleus." [FB:ma] synonym: "Non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000224 ! cell by nuclear number [Term] id: CL:0000226 name: single nucleate cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0002242 ! nucleate cell [Term] id: CL:0000227 name: binucleate cell is_a: CL:0000228 ! multinucleate cell [Term] id: CL:0000228 name: multinucleate cell def: "A cell with more than one nucleus." [FB:ma] synonym: "syncitium" EXACT [] synonym: "syncytial cell" EXACT [] synonym: "syncytium" EXACT [] is_a: CL:0002242 ! nucleate cell [Term] id: CL:0000229 name: lymphoblast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. is_obsolete: true [Term] id: CL:0000230 name: T lymphoblast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. is_obsolete: true [Term] id: CL:0000231 name: B lymphoblast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000232 name: erythrocyte def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A.11.118.290] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000558 ! reticulocyte [Term] id: CL:0000233 name: platelet def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:tfm, MESH:A.11.118.188] synonym: "blood platelet" EXACT [] synonym: "thrombocyte" RELATED [] xref: FMA:62851 is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 ! myeloid cell relationship: develops_from CL:0000556 ! megakaryocyte [Term] id: CL:0000234 name: phagocyte def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] xref: FMA:83806 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell [Term] id: CL:0000235 name: macrophage def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. synonym: "histiocyte" EXACT [] xref: FMA:63261 xref: FMA:83585 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000576 ! monocyte [Term] id: CL:0000236 name: B cell def: "A lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: FMA:62869 is_a: CL:0000945 ! lymphocyte of B lineage relationship: develops_from CL:0000826 ! pro-B cell [Term] id: CL:0000237 name: keratinizing barrier epithelial cell is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000238 name: non keratinizing barrier epithelial cell is_a: CL:0000240 ! stratified squamous epithelial cell [Term] id: CL:0000239 name: brush border epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000240 name: stratified squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000241 name: stratified cuboidal epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000242 name: Merkel cell def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A.08.800.550.700.500.425] synonym: "Merkel,s cell" EXACT [] xref: FMA:70548 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0002185 ! keratinized cell of epidermis [Term] id: CL:0000243 name: glial cell (sensu Vertebrata) def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A.08.637] is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000244 name: transitional epithelial cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544] xref: FMA:66778 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000245 name: passage cell def: "Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208] is_a: CL:0000293 ! structural cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000246 name: Mauthner neuron is_a: CL:0000099 ! interneuron [Term] id: CL:0000247 name: Rohon-Beard neuron is_a: CL:0000531 ! primary sensory neuron [Term] id: CL:0000248 name: microsporocyte def: "A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208] synonym: "pollen mother cell" EXACT [] synonym: "primary sporogenous cell" EXACT [] is_a: CL:0000610 ! plant cell [Term] id: CL:0000249 name: hatching gland cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000250 name: megaspore def: "A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208] is_a: CL:0002392 ! plant spore relationship: develops_from CL:0000320 ! megasporocyte [Term] id: CL:0000251 name: extramedullary cell is_a: CL:0000101 ! sensory neuron [Term] id: CL:0000252 name: microspore def: "A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208] synonym: "pollen" RELATED [] is_a: CL:0002392 ! plant spore relationship: develops_from CL:0000248 ! microsporocyte [Term] id: CL:0000253 name: eurydendroid cell is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000254 name: egg cell def: "The female gamete of plants." [TAIR:lr] synonym: "female gametophyte egg cell" EXACT [] is_a: CL:0000610 ! plant cell [Term] id: CL:0000255 name: eukaryotic cell is_a: CL:0000004 ! cell by organism [Term] id: CL:0000256 name: uric acid accumulating cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000257 name: Mycetozoan cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000258 name: fiber tracheid def: "A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208] is_a: CL:0000672 ! tracheary element [Term] id: CL:0000259 name: aggregate cell def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000260 name: mucilage cell def: "Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208] is_a: CL:0000151 ! secretory cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000261 name: anterior cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000262 name: guard mother cell def: "An epidermal cell that divides to produce the guard cells." [ISBN:0471245208] is_a: CL:0000362 ! epidermal cell is_a: CL:0000610 ! plant cell relationship: develops_from CL:0000538 ! epidermal initial [Term] id: CL:0000263 name: vegetative cell (sensu Mycetozoa) def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB] synonym: "amoeba" EXACT [] is_a: CL:0000257 ! Mycetozoan cell [Term] id: CL:0000264 name: phloem initial def: "A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208] synonym: "phloem mother cell" EXACT [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000272 ! cambial initial [Term] id: CL:0000265 name: anterior like cell def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB] synonym: "ALC" EXACT [] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000266 name: meristemoid def: "A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208] is_a: CL:0000610 ! plant cell [Term] id: CL:0000267 name: prespore cell def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000268 name: sieve element def: "The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208] is_a: CL:0000610 ! plant cell is_a: CL:0000627 ! transporting cell [Term] id: CL:0000269 name: prestalk cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000270 name: subsidiary cell def: "An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520] synonym: "accessory cell" RELATED [] xref: PO:0000296 is_a: CL:0000293 ! structural cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000271 name: prestalk A cell def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstA" EXACT [] synonym: "pstAO" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000272 name: cambial initial def: "A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000685 ! meristematic cell [Term] id: CL:0000273 name: prestalk AB cell def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstAB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000275 name: prestalk B cell def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB] synonym: "pstB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000276 name: sclerenchyma cell def: "Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208] is_a: CL:0000293 ! structural cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000277 name: prestalk I cell def: "Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000278 name: central cell def: "A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr] is_a: CL:0000610 ! plant cell [Term] id: CL:0000279 name: prestalk 0 cell def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000280 name: generative cell def: "The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr] is_a: CL:0000610 ! plant cell [Term] id: CL:0000281 name: pstAB/ALC def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000282 name: trichome def: "An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806] is_a: CL:0000362 ! epidermal cell relationship: develops_from CL:0000538 ! epidermal initial [Term] id: CL:0000283 name: pstO/ALC def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000284 name: companion cell def: "A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322] is_a: CL:0000630 ! supportive cell is_a: CL:0000668 ! parenchymal cell [Term] id: CL:0000285 name: stalk cell def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000286 name: hyphal cell def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X] is_a: CL:0000521 ! fungal cell [Term] id: CL:0000287 name: eye photoreceptor cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000288 name: synergid def: "A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208] is_a: CL:0000610 ! plant cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000289 name: chemotactic amoeboid cell (sensu Mycetozoa) def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) is_a: CL:0000732 ! amoeboid cell [Term] id: CL:0000290 name: xylem fiber cell def: "A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208] is_a: CL:0000293 ! structural cell is_a: CL:0000298 ! xylem element [Term] id: CL:0000291 name: spore (sensu Mycetozoa) def: "Dormant cell protected by a tri-layer spore coat. The spore has an elliptical shape and is approximately 6-9 microns by 3 microns." [DDB_REF:5048, DictyBase:DDB, PMID:4338436] xref: DDANAT:0000414 is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000292 name: guard cell def: "One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208] synonym: "stomatal guard cell" EXACT [] is_a: CL:0000362 ! epidermal cell is_a: CL:0000610 ! plant cell relationship: develops_from CL:0000262 ! guard mother cell [Term] id: CL:0000293 name: structural cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000144 ! cell by function [Term] id: CL:0000294 name: sieve cell def: "A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208] is_a: CL:0000268 ! sieve element [Term] id: CL:0000295 name: somatotropin secreting cell alt_id: CL:0000471 def: "A peptide hormone cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000296 name: vegetative cell def: "Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr] is_a: CL:0000610 ! plant cell [Term] id: CL:0000297 name: socket cell def: "A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806] is_a: CL:0000362 ! epidermal cell is_a: CL:0000630 ! supportive cell relationship: develops_from CL:0000538 ! epidermal initial [Term] id: CL:0000298 name: xylem element def: "A cell composing the xylem." [ISBN:0471245208] is_a: CL:0000363 ! axial cell is_a: CL:0000627 ! transporting cell [Term] id: CL:0000299 name: trichoblast def: "Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208] comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262). is_obsolete: true [Term] id: CL:0000300 name: gamete def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: FBbt:00005412 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 ! germ cell [Term] id: CL:0000301 name: pole cell xref: FBbt:00000092 is_a: CL:0000670 ! primordial germ cell [Term] id: CL:0000302 name: IgM B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000303 name: IgG B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000304 name: IgA B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000305 name: IgE B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000306 name: crystallin accumulating cell synonym: "cone cell" EXACT [] synonym: "lens cell" EXACT [] xref: FBbt:00004193 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell def: "An epithelial cell found in the trachea." [GOC:tfm] synonym: "tracheocyte" EXACT [] xref: FBbt:00005038 xref: FMA:74793 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree relationship: develops_from CL:0000377 ! tracheoblast [Term] id: CL:0000308 name: metal ion accumulating cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000309 name: copper accumulating cell synonym: "cuprophilic cell" EXACT [] is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000310 name: iron accumulating cell is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000312 name: keratinocyte def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [MESH:A.11.436.397] synonym: "malpighian cell" EXACT [] xref: FMA:62879 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0000362 ! epidermal cell [Term] id: CL:0000313 name: serous secreting cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] synonym: "serous cell" EXACT [] xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000314 name: milk secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000315 name: tears secreting cell def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A.12.200.882] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000316 name: ray initial def: "A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208] is_a: CL:0000272 ! cambial initial [Term] id: CL:0000317 name: sebum secreting cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A.12.200.702] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000318 name: sweat secreting cell def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A.12.200.849] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000319 name: mucus secreting cell synonym: "mucous cell" EXACT [] is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000320 name: megasporocyte def: "A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208] synonym: "archesporial cell" EXACT [] synonym: "megaspore mother cell" EXACT [] is_a: CL:0000610 ! plant cell [Term] id: CL:0000321 name: seminal fluid secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000322 name: pneumocyte def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144] synonym: "Alveolar epithelial cell" EXACT [] synonym: "Pneumonocyte" EXACT [] xref: FMA:62499 is_a: CL:0002368 ! respiratory epithelial cell [Term] id: CL:0000323 name: lysozyme secreting cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000324 name: metanephric mesenchyme stem cell is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000325 name: stuff accumulating cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] is_a: CL:0000144 ! cell by function [Term] id: CL:0000326 name: glycogen accumulating cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell is_a: CL:0000151 ! secretory cell is_a: CL:0000499 ! stromal cell [Term] id: CL:0000328 name: myelin accumulating cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000329 name: oxygen accumulating cell is_a: CL:0000144 ! cell by function [Term] id: CL:0000330 name: collenchymal cell def: "An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208] is_a: CL:0000063 ! cell by histology is_a: CL:0000610 ! plant cell [Term] id: CL:0000331 name: tracheid def: "A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208] is_a: CL:0000672 ! tracheary element [Term] id: CL:0000332 name: atrichoblast def: "A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819] synonym: "non-hair cell" RELATED [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000538 ! epidermal initial [Term] id: CL:0000333 name: neural crest cell def: "A cell of the strip of specialized ectoderm flanking each side of the embryonal neural plate, which after the closure of the neural tube, forms a column of isolated cells along the dorsal aspect of the neural tube. Most of the cranial and all of the spinal sensory ganglion cells arise by differentiation of neural crest cells." [MESH:A.16.254.600] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0000220 ! cell by lineage is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) synonym: "yeast-form" RELATED [] xref: FAO:0000032 is_a: CL:0000521 ! fungal cell [Term] id: CL:0000335 name: mesenchyme condensation cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0000134 ! mesenchymal cell [Term] id: CL:0000336 name: adrenal medulla chromaffin cell def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland] synonym: "chromafin cell" EXACT [] xref: FMA:69262 is_a: CL:0000166 ! chromaffin cell is_a: CL:0000457 ! biogenic amine secreting cell relationship: develops_from CL:0000011 ! trunk neural crest cell [Term] id: CL:0000337 name: neuroblast (sensu Vertebrata) def: "An embryonic cell that develops into a nerve cell or neuron." [FMA:70563] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) synonym: "neuroblast" BROAD [] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256] synonym: "Spongioblast" EXACT [] xref: FMA:70564 is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) [Term] id: CL:0000340 name: glioblast (sensu Nematoda and Protostomia) is_a: CL:0000030 ! glioblast is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) is_a: CL:0000147 ! pigment cell [Term] id: CL:0000342 name: pigment cell (sensu Vertebrata) def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000343 name: visual pigment cell (sensu Vertebrata) def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm] xref: FMA:63846 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000342 ! pigment cell (sensu Vertebrata) [Term] id: CL:0000344 name: non-visual cell (sensu Vertebrata) is_obsolete: true [Term] id: CL:0000345 name: dental papilla cell def: "A small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544] is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000346 name: hair papilla cell def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [GOC:tfm, PMID:9893172] is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000347 name: scleral cell def: "A cell of the sclera of the eye." [GOC:add] is_a: CL:0000293 ! structural cell relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000348 name: choroidal cell of the eye def: "A cell of the choroid of the eye." [GOC:add] is_a: CL:0000293 ! structural cell relationship: develops_from CL:0000008 ! cranial neural crest cell [Term] id: CL:0000349 name: extraembryonic cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000350 name: amnioserosal cell is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000351 name: trophoblast cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A.11.936] synonym: "Trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000352 name: epiblast cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A.11.104] synonym: "blastomere" EXACT [] xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000354 name: blastemal cell is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0000355 name: muscle stem cell def: "A cell that resides beneath the basal lamina of muscle closely juxtaposed to muscle fibers. Cell is normally mitotically quiescent, but they is activated in response to stress induced by weight bearing or by trauma such as injury." [PMID:19329572] xref: FMA:86767 is_a: CL:0000035 ! single fate stem cell is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000356 name: hair matrix stem cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000357 name: stratified epithelial stem cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000358 name: sphincter associated smooth muscle cell is_a: CL:0000192 ! smooth muscle cell [Term] id: CL:0000359 name: vascular associated smooth muscle cell is_a: CL:0000192 ! smooth muscle cell [Term] id: CL:0000360 name: morula cell def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A.16.254.270.550] is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000361 name: gastrula cell def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A.16.254.412] is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000362 name: epidermal cell def: "A cell found in the outermost layer of the organism." [MA:ma] xref: FMA:62411 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell [Term] id: CL:0000363 name: axial cell def: "A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208] is_a: CL:0000293 ! structural cell relationship: develops_from CL:0000009 ! fusiform initial [Term] id: CL:0000364 name: ray cell def: "A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208] is_a: CL:0000293 ! structural cell relationship: develops_from CL:0000316 ! ray initial [Term] id: CL:0000365 name: zygote def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] xref: FMA:72395 xref: PO:0000423 is_a: CL:0000007 ! early embryonic cell is_a: CL:0000220 ! cell by lineage [Term] id: CL:0000366 name: sperm cell (sensu Viridiplantae) def: "Male gamete, part of male germ unit." [ISBN:0471245208] synonym: "gametophyte sperm cell" RELATED [] synonym: "male gametophyte sperm cell" RELATED [] synonym: "pollen germ cell " RELATED [] xref: PO:0000084 is_a: CL:0000610 ! plant cell relationship: develops_from CL:0000280 ! generative cell [Term] id: CL:0000367 name: sheath cell (sensu Nematoda) synonym: "glial cell (sensu Nematoda)" RELATED [] is_a: CL:0000619 ! support cell (sensu Nematoda) [Term] id: CL:0000368 name: myrosin cell def: "Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208] is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000369 name: single cell sarcomere is_a: CL:0000187 ! muscle cell [Term] id: CL:0000370 name: transfer cell def: "Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208] synonym: "intermediary cell" RELATED [] is_a: CL:0000627 ! transporting cell is_a: CL:0000668 ! parenchymal cell [Term] id: CL:0000371 name: protoplast def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X] is_a: CL:0000578 ! experimentally modified cell [Term] id: CL:0000372 name: tormogen cell synonym: "socket cell" RELATED [] xref: FBbt:00005171 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000373 name: histoblast xref: FBbt:00001789 is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000374 name: trichogen cell def: "A large cell that secretes the long, tapering hair of the insect bristle. A smaller tormogen cell forms the circular chitinous socket around the base of the bristle." [GOC:tfm, http://www.jrank.org/health/pages/20801/trichogen-cell.html] synonym: "hair cell" BROAD [] xref: FBbt:00005169 is_a: CL:0000098 ! sensory epithelial cell [Term] id: CL:0000375 name: osteoprogenitor cell is_a: CL:0000035 ! single fate stem cell relationship: develops_from CL:0000335 ! mesenchyme condensation cell [Term] id: CL:0000376 name: humidity receptor cell is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:0000377 name: tracheoblast is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000378 name: support cell (sensu Nematoda and Protostomia) is_a: CL:0000630 ! supportive cell [Term] id: CL:0000379 name: sensory processing neuron is_a: CL:0000540 ! neuron [Term] id: CL:0000380 name: thecogen cell def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173] synonym: "fly sheath cell" EXACT [] is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000381 name: neurosecretory neuron xref: FBbt:00005130 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000382 name: scolopidium synonym: "scolopale cell" EXACT [] xref: FBbt:00005217 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000383 name: nephrogenic mesenchyme stem cell is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000384 name: ligament cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) xref: FBbt:00005062 is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) [Term] id: CL:0000386 name: attachment cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000387 name: hemocyte (sensu Nematoda and Protostomia) is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000388 name: tendon cell synonym: "muscle attachment cell" EXACT [] is_a: CL:0000386 ! attachment cell [Term] id: CL:0000389 name: socket cell (sensu Nematoda) is_a: CL:0000619 ! support cell (sensu Nematoda) is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) is_a: CL:0000081 ! blood cell [Term] id: CL:0000391 name: podocyte (sensu Diptera) def: "An insect immune cell that develops from plasmatocyte." [PMID:12930778] is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000394 ! plasmatocyte [Term] id: CL:0000392 name: crystal cell is_a: CL:0000391 ! podocyte (sensu Diptera) [Term] id: CL:0000393 name: electrically responsive cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000394 name: plasmatocyte xref: FBbt:00001685 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000395 name: procrystal cell xref: FBbt:00001689 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000396 name: lamellocyte xref: FBbt:00001687 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000397 name: ganglion interneuron is_a: CL:0000099 ! interneuron [Term] id: CL:0000398 name: polygonal cell xref: FBbt:00001691 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000399 name: phloem element is_a: CL:0000627 ! transporting cell relationship: develops_from CL:0000264 ! phloem initial [Term] id: CL:0000400 name: pavement cell def: "An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289] is_a: CL:0000362 ! epidermal cell relationship: develops_from CL:0000538 ! epidermal initial [Term] id: CL:0000401 name: macrophage (sensu Diptera) xref: FBbt:00001686 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000402 name: CNS interneuron is_a: CL:0000099 ! interneuron is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000404 name: electrically signaling cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000405 name: neuroepidermoblast xref: FBbt:00005148 is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000406 name: CNS short range interneuron is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000407 name: scolopidial ligament cell xref: FBbt:00005221 is_a: CL:0000384 ! ligament cell [Term] id: CL:0000408 name: male gamete is_a: CL:0000015 ! male germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000409 name: scolopidial sheath cell xref: FBbt:00005219 is_a: CL:0000618 ! sheath cell [Term] id: CL:0000410 name: CNS long range interneuron is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000411 name: hypodermal cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000228 ! multinucleate cell [Term] id: CL:0000412 name: polyploid cell def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma] is_a: CL:0000414 ! cell by ploidy [Term] id: CL:0000413 name: haploid cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000414 ! cell by ploidy [Term] id: CL:0000414 name: cell by ploidy def: "A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm] is_a: CL:0000012 ! cell by class [Term] id: CL:0000415 name: diploid cell def: "A cell whose nucleus has two haploid genomes." [FB:ma] is_a: CL:0000414 ! cell by ploidy [Term] id: CL:0000416 name: polytene cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000417 name: endopolyploid cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000418 name: arcade cell def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tf\,, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000419 name: seam cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000420 name: syncytial epithelial cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000228 ! multinucleate cell [Term] id: CL:0000421 name: coelomocyte def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544] is_a: CL:0000080 ! circulating cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000422 name: mitogenic signaling cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma] is_a: CL:0000144 ! cell by function [Term] id: CL:0000423 name: tip cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000425 name: pore cell def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb] is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000426 name: scaffold cell is_a: CL:0000445 ! apoptosis fated cell [Term] id: CL:0000427 name: GLR cell def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm] is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000428 name: yolk cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000429 name: imaginal disc cell is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000430 name: xanthophore def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005002 ! xanthoblast [Term] id: CL:0000431 name: iridophore def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005001 ! iridoblast [Term] id: CL:0000432 name: reticular cell def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, ISBN:0517223651] synonym: "reticulum cell" EXACT [] xref: FMA:62877 is_a: CL:0000057 ! fibroblast [Term] id: CL:0000433 name: functional megaspore def: "In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr] is_a: CL:0000250 ! megaspore [Term] id: CL:0000434 name: eccrine cell def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000435 name: alkali secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000436 name: vaginal lubricant secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000437 name: gonadtroph def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http:63.198.234.228/OpenFMA/Gonadotroph.html, ISBN:0517223651] synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] synonym: "Gonadotrope" EXACT [] synonym: "Gonadotrope cell" EXACT [] synonym: "gonadotroph" EXACT [] synonym: "Pituitary delta cell" EXACT [] xref: FMA:83100 is_a: CL:0000438 ! luteinizing hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000438 name: luteinizing hormone secreting cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000439 name: prolactin secreting cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl] synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000441 name: follicle stem cell xref: FBbt:00004903 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000442 name: follicular dendritic cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252] comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. xref: FMA:83037 is_a: CL:0000473 ! defensive cell [Term] id: CL:0000443 name: calcitonin secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000444 name: obliquely striated muscle cell is_a: CL:0000737 ! striated muscle cell [Term] id: CL:0000445 name: apoptosis fated cell is_a: CL:0000144 ! cell by function [Term] id: CL:0000446 name: chief cell of parathyroid gland def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651] synonym: "Parathyroid chief cell" EXACT [] synonym: "Parathyroid gland chief cell" EXACT [] synonym: "parathyroid hormone secreting cell" EXACT [] synonym: "Principal cell of parathyroid gland" EXACT [] xref: FMA:69078 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002260 ! epithelial cell of parathyroid gland [Term] id: CL:0000447 name: carbohydrate secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white fat cell def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500] synonym: "white adipocyte" RELATED [] synonym: "White adipose cell" EXACT [] synonym: "White fat cell" EXACT [] xref: FMA:83434 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002334 ! preadipocyte [Term] id: CL:0000449 name: brown fat cell def: "A cell from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A.10.165.114.322] synonym: "Brown adipocyte" EXACT [] synonym: "Brown adipose cell" EXACT [] xref: FMA:83435 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002335 ! brown preadipocyte [Term] id: CL:0000451 name: dendritic cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [GOC:add, ISBN:0781735149] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: FMA:83036 is_a: CL:0000738 ! leukocyte disjoint_from: CL:0000542 ! lymphocyte [Term] id: CL:0000452 name: thyroid hormone secreting cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000453 name: Langerhans cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMID:17850486, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID: 19243617). synonym: "Langerhans' cell" EXACT [] xref: FMA:63072 is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0000454 name: epinephrin secreting cell def: "A cell capable of producting Epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093] synonym: "adrenaline secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell [Term] id: CL:0000455 name: starch sheath cell def: "A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520] is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000610 ! plant cell [Term] id: CL:0000456 name: mineralocorticoid secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000457 name: biogenic amine secreting cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000458 name: serotonin secreting cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell [Term] id: CL:0000459 name: norepinephrin secreting cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] synonym: "noradrenalin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell [Term] id: CL:0000460 name: glucocorticoid secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000461 name: renin secreting cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000462 name: adepithelial cell xref: FBbt:00003219 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000463 name: epidermal cell (sensu Insecta) def: "A columnar/cuboidal epithelial cell which secretes cuticle from its apical side." [FlyBase:ds] is_a: CL:0000075 ! columnar/cuboidal epithelial cell relationship: develops_from CL:0000464 ! epidermoblast [Term] id: CL:0000464 name: epidermoblast def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311] xref: FBbt:00004994 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000465 name: cardioblast (sensu Arthropoda) xref: FBbt:00001666 is_a: CL:0000513 ! cardiac muscle myoblast [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell alt_id: CL:0000640 def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" RELATED [] synonym: "corticotropin hormone secreting cell" RELATED [] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000468 name: neuroglioblast xref: FBbt:00005147 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000469 name: ganglion mother cell xref: FBbt:00005149 is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000470 name: digestive enzyme secreting cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000472 name: chlorenchyma cell def: "Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208] is_a: CL:0000628 ! photosynthetic cell is_a: CL:0000668 ! parenchymal cell [Term] id: CL:0000473 name: defensive cell def: "A cell whose primary function is to protect the organism." [JB:jb] is_a: CL:0000144 ! cell by function [Term] id: CL:0000474 name: pericardial cell xref: FBbt:00003184 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000475 name: degenerate megaspore def: "In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr] is_a: CL:0000250 ! megaspore [Term] id: CL:0000476 name: thyrotroph def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000477 name: follicle cell xref: FBbt:00004904 is_a: CL:0000075 ! columnar/cuboidal epithelial cell relationship: develops_from CL:0000441 ! follicle stem cell [Term] id: CL:0000478 name: oxytocin stimulating hormone secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000479 name: vasopressin stimulating hormone secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000480 name: secretin stimulating hormone secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000481 name: cholecystokin stimulating hormone secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000482 name: juvenile hormone secreting cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000483 name: bombesin stimulating hormone secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000484 name: connective tissue type mast cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] is_a: CL:0000097 ! mast cell [Term] id: CL:0000485 name: mucosal type mast cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] is_a: CL:0000097 ! mast cell [Term] id: CL:0000486 name: garland cell xref: FBbt:00005059 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000487 name: oenocyte def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397] xref: FBbt:00004995 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000488 name: visible light photoreceptor cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000489 name: scotopic photoreceptor cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000490 name: photopic photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000491 name: cytotoxic T cell def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." [] comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. is_obsolete: true [Term] id: CL:0000492 name: CD4-positive helper T cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A.11.118.637.555.567.569.200.400] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: FMA:70572 is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000493 name: regulatory T cell def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." [] comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. is_obsolete: true [Term] id: CL:0000494 name: UV sensitive photoreceptor cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000495 name: blue sensitive photoreceptor cell is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000496 name: green sensitive photoreceptor cell is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000497 name: red sensitive photoreceptor cell is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000498 name: inhibitory interneuron def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron] xref: FMA:84776 is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A.11.329.830] xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000500 name: follicular epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000501 name: granulosa cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A.05.360.319.114.630.535.200] synonym: "granulosa cell of ovary" EXACT [] xref: FMA:18718 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary [Term] id: CL:0000502 name: type D enteroendocrine cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A.03.492.766.440.175] synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell [Term] id: CL:0000503 name: theca cell def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A.05.360.319.114.630.535.400] xref: FMA:18690 is_a: CL:0000499 ! stromal cell is_a: CL:0000593 ! androgen secreting cell [Term] id: CL:0000504 name: enterochromaffin-like cell def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:A.06.224.365] comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. synonym: "ECL" EXACT [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell [Term] id: CL:0000505 name: substance P secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A.03.492.766.440.300] synonym: "G cell " EXACT [] xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell [Term] id: CL:0000509 name: gastrin secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000510 name: Paneth cell def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn). Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A.03.492.411.369.700] xref: FMA:62897 is_a: CL:0000131 ! gut endothelial cell is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000323 ! lysozyme secreting cell [Term] id: CL:0000511 name: androgen binding protein secreting cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000512 name: paracrine cell def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [GOC:tfm, ISBN:0198529171] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000513 name: cardiac muscle myoblast alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A.11.635.470] synonym: "cardioblast" RELATED [] xref: FMA:84797 is_a: CL:0000056 ! myoblast [Term] id: CL:0000514 name: smooth muscle myoblast def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A.11.635.510] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 ! myoblast [Term] id: CL:0000515 name: skeletal muscle myoblast def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 ! myoblast [Term] id: CL:0000516 name: perineuronal satellite cell def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:A.08.340.685] synonym: "perineural satellite cell" EXACT [] synonym: "Perineuronal satellite oligodendroglial cell" EXACT [] synonym: "Satellite oligodendrocyte" EXACT [] xref: FMA:54550 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000517 name: macrophage derived foam cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) def: "A myeloid leukocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) is_a: CL:0000234 ! phagocyte [Term] id: CL:0000520 name: prokaryotic cell is_a: CL:0000004 ! cell by organism [Term] id: CL:0000521 name: fungal cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000522 name: spore def: "The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000523 name: mononuclear cytotrophoblast cell def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908] synonym: "Langhans' cell" EXACT [] xref: FMA:83042 is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000524 name: spheroplast def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A.11.868] synonym: "sphaeroplast" EXACT [] is_a: CL:0000371 ! protoplast [Term] id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] synonym: "plasmidotrophoblast" EXACT [] synonym: "syncytial trophoblast" EXACT [] synonym: "syntrophoblast" EXACT [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000526 name: afferent neuron def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A.08.663.650] synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000029 ! neuron neural crest derived [Term] id: CL:0000527 name: efferent neuron def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A.08.663.655] synonym: "output neuron" EXACT [] is_a: CL:0000029 ! neuron neural crest derived [Term] id: CL:0000528 name: nitrergic neuron def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:A.08.663.748] xref: FMA:84792 is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000529 name: pigmented epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron is_a: CL:0000540 ! neuron [Term] id: CL:0000531 name: primary sensory neuron is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000532 name: CAP motoneuron is_a: CL:0000533 ! primary motor neuron [Term] id: CL:0000533 name: primary motor neuron xref: FMA:83619 is_a: CL:0000100 ! motor neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000534 name: primary interneuron is_a: CL:0000099 ! interneuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000535 name: secondary neuron is_a: CL:0000540 ! neuron [Term] id: CL:0000536 name: secondary motor neuron xref: FMA:83620 is_a: CL:0000100 ! motor neuron is_a: CL:0000535 ! secondary neuron [Term] id: CL:0000537 name: antipodal cell def: "A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208] is_a: CL:0000610 ! plant cell [Term] id: CL:0000538 name: epidermal initial def: "A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000685 ! meristematic cell [Term] id: CL:0000539 name: idioblast def: "A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000540 name: neuron def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MESH:A.08.663] synonym: "nerve cell" EXACT [] xref: FBbt:00005106 xref: FMA:54527 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000031 ! neuroblast [Term] id: CL:0000541 name: melanoblast def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl] comment: Derived from UBERON:0002342 neural crest. xref: FMA:83377 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000542 name: lymphocyte def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] xref: FMA:62863 is_a: CL:0000738 ! leukocyte is_a: CL:0002087 ! nongranular leukocyte disjoint_from: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000543 name: sieve tube member def: "One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208] synonym: "sieve tube element" EXACT [] is_a: CL:0000268 ! sieve element [Term] id: CL:0000544 name: slowly adapting mechanoreceptor cell is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000545 name: T-helper 1 cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875] synonym: "helper T cell type 1" EXACT [] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: FMA:84382 is_a: CL:0000492 ! CD4-positive helper T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000546 name: T-helper 2 cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781] synonym: "helper T cell type 2" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: FMA:84385 is_a: CL:0000492 ! CD4-positive helper T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000547 name: proerythroblast def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A.11.118.290.350.200, PMID:1638021] synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000038 ! erythroid progenitor cell [Term] id: CL:0000548 name: animal cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000549 name: basophilic erythroblast def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 ! erythroblast relationship: develops_from CL:0000547 ! proerythroblast [Term] id: CL:0000550 name: polychromatophilic erythroblast def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 ! erythroblast relationship: develops_from CL:0000549 ! basophilic erythroblast [Term] id: CL:0000551 name: unimodal nocireceptor is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000552 name: orthochromatic erythroblast def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 ! erythroblast relationship: develops_from CL:0000550 ! polychromatophilic erythroblast [Term] id: CL:0000553 name: megakaryocyte progenitor cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:tfm, ISBN:0721601464] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: FMA:84235 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000554 name: gastrin stimulating hormone secreting cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000555 name: neuronal brush cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000556 name: megakaryocyte def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [ISBN:0721601464] synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: FMA:83555 is_a: CL:0000414 ! cell by ploidy is_a: CL:0000763 ! myeloid cell is_a: CL:0002092 ! bone marrow cell relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMID:15684376, PMID:15867096, PMID:16551251] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID: 19243617). synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] synonym: "CFU-GM" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096] synonym: "GMP" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000049 ! common myeloid progenitor disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000558 name: reticulocyte def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] is_a: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000552 ! orthochromatic erythroblast [Term] id: CL:0000559 name: promonocyte def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, http://www.clt.astate.edu/wwilliam/, ISBN:0721601464] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. xref: FMA:83551 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell relationship: develops_from CL:0000040 ! monoblast [Term] id: CL:0000560 name: band form neutrophil def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520] synonym: "band" BROAD [] synonym: "band cell" EXACT [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" EXACT [] is_a: CL:0000776 ! immature neutrophil relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte [Term] id: CL:0000561 name: amacrine cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:A.08.663.358.050] comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748) synonym: "amacrine neuron" EXACT [] xref: FBbt:00005127 xref: FMA:67766 is_a: CL:0000099 ! interneuron [Term] id: CL:0000562 name: nucleate erythrocyte def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 ! erythrocyte relationship: develops_from CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000563 name: endospore def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [GOC:tfm, ISBN:0618947256] synonym: "bacterial spore" EXACT [] is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte def: "A promyelocyte committed to the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] xref: FMA:84196 is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 ! promyelocyte relationship: develops_from CL:0000042 ! neutrophilic myeloblast [Term] id: CL:0000565 name: fat body cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000181 ! metabolising cell [Term] id: CL:0000566 name: angioblastic mesenchymal cell synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000567 name: polymodal nocireceptor is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: APUD cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. THis cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544, MESH:A.11.070] synonym: "Amine precursor uptake and decarboxylation cell" EXACT [] xref: FMA:83114 is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell def: "A mesenchymal cell found in the developing heart." [PMID:18816864] is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000011 ! trunk neural crest cell [Term] id: CL:0000570 name: parafollicular cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secrets calcitonin, 5-hydroxytryptamine and dopamine." [GOC:tfm, ISBN:0517223651] synonym: "C cell" EXACT [] xref: FMA:68653 is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000571 name: leucophore def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005003 ! leucoblast [Term] id: CL:0000573 name: retinal cone cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A.08.663.650.650.670.100] xref: FMA:67748 is_a: CL:0000287 ! eye photoreceptor cell [Term] id: CL:0000574 name: erythrophore def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005004 ! pigment erythroblast [Term] id: CL:0000575 name: corneal epithelial cell xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell [Term] id: CL:0000576 name: monocyte def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, http://www.clt.astate.edu/wwilliam/, MESH:A.11.118.637.555.652] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: FMA:62864 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002087 ! nongranular leukocyte relationship: develops_from CL:0000559 ! promonocyte [Term] id: CL:0000577 name: type EC enteroendocrine cell alt_id: CL:0002065 def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [MESH:A.03.492.766.440.250, PMID:9505449] synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000506 ! enkephalin secreting cell [Term] id: CL:0000578 name: experimentally modified cell def: "A cell that has been changed as a consequence of a deliberate and specific experimental procedure." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000579 name: border follicle cell xref: FBbt:00004905 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000580 name: neutrophilic myelocyte def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520] xref: FMA:83540 is_a: CL:0000776 ! immature neutrophil is_a: CL:0002193 ! myelocyte relationship: develops_from CL:0000564 ! neutrophilic promyelocyte [Term] id: CL:0000581 name: peritoneal macrophage def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, Dectin-1-positive." [MESH:A.11.329.372.630, PMID:15771589, PMID:19201820] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: FMA:83025 is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000582 name: neutrophilic metamyelocyte def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520] synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 is_a: CL:0000776 ! immature neutrophil is_a: CL:0002192 ! metamyelocyte relationship: develops_from CL:0000580 ! neutrophilic myelocyte [Term] id: CL:0000583 name: alveolar macrophage def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:A.11.329.372.600] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] xref: FMA:83023 is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000584 name: enterocyte def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl] xref: FMA:62122 is_a: CL:0000239 ! brush border epithelial cell [Term] id: CL:0000585 name: null cell def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." [] comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. is_obsolete: true [Term] id: CL:0000586 name: germ cell def: "The reproductive cell in multicellular organisms." [MESH:A.05.360.490] is_a: CL:0000039 ! germ line cell [Term] id: CL:0000587 name: cold sensing thermoreceptor cell is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A.11.329.679] xref: FMA:83027 is_a: CL:0000092 ! osteoclast [Term] id: CL:0000589 name: cochlear inner hair cell def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A.08.663.650.250.250] synonym: "inner hair cell" BROAD [] xref: FMA:62365 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000590 name: small luteal cell def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [GOC:tfm, MESH:A.05.360.319.114.630.278.400] synonym: "small lutein cell" EXACT [] synonym: "Theca lutein cell" EXACT [] xref: FMA:18690 is_a: CL:0000175 ! luteal cell is_a: CL:0000179 ! progesterone secreting cell relationship: develops_from CL:0000503 ! theca cell [Term] id: CL:0000591 name: warmth sensing thermoreceptor cell is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000592 name: large luteal cell def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [GOC:tfm, MESH:A.05.360.319.114.630.278.400] synonym: "Granulosa lutein cell" EXACT [] synonym: "Granulosoluteocytus" RELATED [] xref: FMA:18689 is_a: CL:0000175 ! luteal cell is_a: CL:0000177 ! testosterone secreting cell relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000593 name: androgen secreting cell is_a: CL:0000174 ! steroid hormone secreting cell [Term] id: CL:0000594 name: skeletal muscle satellite cell def: "An elongated, spindle-shaped, quiescent myoblast that are located between the basal lamina and the plasmalemma of the muscle fibres. They are thought to play a role in muscle repair and regeneration." [GOC:tfm, MESH:A.11.635.500.700] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000595 name: enucleate erythrocyte def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 ! erythrocyte relationship: develops_from CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000596 name: sexual spore def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000597 name: microconidium def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [GOC:tfm, ISBN:0471940526, PMID:8357339, SGD:clt] xref: FAO:0000028 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0000598 name: pyramidal cell def: "A projection neuron in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region." [GOC:tfm, MESH:A.08.186.211.577.405.700] synonym: "projection neuron" EXACT [] synonym: "pyramidal neuron" EXACT [] xref: FMA:86775 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000599 name: conidium def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [ISBN:08199377X, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000024 is_a: CL:0000605 ! asexual spore [Term] id: CL:0000600 name: heterokaryon def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000521 ! fungal cell [Term] id: CL:0000601 name: outer hair cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A.08.663.650.250.315] synonym: "cochlear outer hair cell" EXACT [] xref: FMA:62366 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000602 name: pressoreceptor cell def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A.08.800.050.800.900.700] is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000603 name: dikaryon def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X] is_a: CL:0000227 ! binucleate cell is_a: CL:0000521 ! fungal cell is_a: CL:0000600 ! heterokaryon [Term] id: CL:0000604 name: retinal rod cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A.08.663.650.650.670.650] xref: FMA:67747 is_a: CL:0000287 ! eye photoreceptor cell [Term] id: CL:0000605 name: asexual spore def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [GOC:tfm, ISBN:0471940526, SGD:clt] xref: FAO:0000038 is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [GOC:tfm, ISBN:08199377X, SGD:clt] xref: FAO:0000020 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [ISBN:0471940526, ISBN:08199377X, SGD:clt] xref: FAO:0000040 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:A.08.663.650.250.380] synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! inner ear hair cell [Term] id: CL:0000610 name: plant cell def: "A cell found in seeded plants." [TAIR:syr] is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000611 name: eosinophil progenitor cell comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA—1, Ly6G, Ly76). synonym: "CFU-Eo" RELATED [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" EXACT [PMID:15955840, PMID:19114669] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000612 name: eosinophilic myelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [GOC:add, GOC:dsd, http://www.cap.org, ISBN:0721601464, PMID:19622087] xref: FMA:83542 is_a: CL:0000772 ! immature eosinophil is_a: CL:0002193 ! myelocyte [Term] id: CL:0000613 name: basophil progenitor cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMID:16330751] comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0002028 ! basophil mast progenitor cell [Term] id: CL:0000614 name: basophilic myelocyte def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030] xref: FMA:83543 is_a: CL:0000768 ! immature basophil relationship: develops_from CL:0000830 ! basophilic promyelocyte [Term] id: CL:0000615 name: basidiospore def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [GOC:clt, ISBN:0471940526, ISBN:08199377X] xref: FAO:0000021 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000616 name: sporangiospore def: "A walled spore produced in a sporangium." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000617 name: GABAergic neuron def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 xref: WBbt:0005190 is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000618 name: sheath cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000619 name: support cell (sensu Nematoda) is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia) is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000620 name: zoospore def: "A sporangiospore that is motile, having flagella." [ISBN:08199377X] xref: FAO:0000039 is_obsolete: true [Term] id: CL:0000621 name: fusion competent myoblast is_a: CL:0000056 ! myoblast [Term] id: CL:0000622 name: acinar cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000623 name: natural killer cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: FMA:63147 xref: FMA:83601 is_a: CL:0000542 ! lymphocyte disjoint_from: CL:0000084 ! T cell relationship: develops_from CL:0000825 ! pro-NK cell [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell [Term] id: CL:0000626 name: olfactory granule cell def: "Granule cell that is part of the olfactory bulb." [GOC:mah] is_a: CL:0000120 ! granule cell [Term] id: CL:0000627 name: transporting cell def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr] is_a: CL:0000144 ! cell by function [Term] id: CL:0000628 name: photosynthetic cell def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr] is_a: CL:0000144 ! cell by function [Term] id: CL:0000629 name: storage cell def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000630 name: supportive cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] xref: FMA:86947 is_a: CL:0000144 ! cell by function [Term] id: CL:0000631 name: labyrinth supporting cell def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:A.09.246.631.246.577.543] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000632 name: ito cell synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "perisinusoidal cell" EXACT [] xref: FMA:67763 is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000633 name: Hensen cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "Cell of Hensen" EXACT [] synonym: "External limiting cell of organ of Corti" EXACT [] synonym: "Hensen's cell" EXACT [] xref: FMA:79799 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000634 name: Claudius cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "Cell of Claudius" EXACT [] synonym: "Claudius cell" EXACT [] synonym: "External supporting cell of Claudius" EXACT [] synonym: "External supporting cell of vestibular epithelium" EXACT [] xref: FMA:79802 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544] synonym: "outer phalangeal cell" EXACT [] xref: FMA:75725 is_a: CL:0002165 ! phalangeal cell of cochlea [Term] id: CL:0000636 name: Muller cell is_a: CL:0000127 ! astrocyte [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256] xref: FMA:83089 is_a: CL:0000163 ! endocrine cell is_a: CL:0000166 ! chromaffin cell [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "Acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "Acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "Acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "Pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis def: "A basophillic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] xref: FMA:83094 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000641 name: chromophobe cell def: "A cell that is resistant to stains." [GOC:tfm] synonym: "chromophobic cell" EXACT [] xref: FMA:83626 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000642 name: folliculostellate cell def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb] is_a: CL:0000163 ! endocrine cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000644 name: Bergmann glial cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000645 name: pituicyte def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://63.198.234.228/OpenFMA/Pituicyte.html, ISBN:0412046911, ISBN:0517223651] xref: FMA:83503 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000646 name: basal cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, http://63.198.234.228/OpenFMA/Basal cell.html, ISBN:0517223651] xref: FMA:62516 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000647 name: multinucleated giant cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:0702024783] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] xref: FMA:83035 is_a: CL:0000224 ! cell by nuclear number is_a: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000648 name: juxtaglomerular cell xref: FMA:84138 is_a: CL:0000192 ! smooth muscle cell [Term] id: CL:0000649 name: prickle cell def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer. A function of this cell is to generate keratin." [GOC:tfm, ISBN:0721662544, ISBN:0815332181] is_a: CL:0000312 ! keratinocyte [Term] id: CL:0000650 name: mesangial cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial cells] xref: FMA:70972 is_a: CL:0000669 ! pericyte cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000651 name: neck cell def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm] synonym: "mucous neck cell" EXACT [] is_a: CL:0000319 ! mucus secreting cell [Term] id: CL:0000652 name: pinealocyte def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://63.198.234.228/OpenFMA/Pinealocyte.html, ISBN:0517223651, PMID:16687276] xref: FMA:83417 is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000653 name: podocyte is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000654 name: primary oocyte def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544] xref: FMA:18645 is_a: CL:0000023 ! oocyte relationship: develops_from CL:0000024 ! oogonial cell [Term] id: CL:0000655 name: secondary oocyte def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544] xref: FMA:18646 is_a: CL:0000023 ! oocyte relationship: develops_from CL:0000654 ! primary oocyte [Term] id: CL:0000656 name: primary spermatocyte def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544] xref: FMA:72292 is_a: CL:0000017 ! spermatocyte is_a: CL:0000414 ! cell by ploidy [Term] id: CL:0000657 name: secondary spermatocyte def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544] xref: FBbt:00004941 xref: FMA:72293 is_a: CL:0000017 ! spermatocyte is_a: CL:0000413 ! haploid cell relationship: develops_from CL:0000656 ! primary spermatocyte [Term] id: CL:0000658 name: cuticle secreting cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000659 name: eggshell secreting cell is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000500 ! follicular epithelial cell [Term] id: CL:0000660 name: glycocalyx secreting cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000662 name: neuroglioblast (sensu Nematoda) is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000663 name: valve cell is_a: CL:0000144 ! cell by function [Term] id: CL:0000664 name: closable valve cell is_a: CL:0000185 ! myoepithelial cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000665 name: permanently open valve cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000666 name: fenestrated cell synonym: "window cell" EXACT [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000667 name: collagen secreting cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000668 name: parenchymal cell def: "The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [ISBN:0471245208] comment: cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. xref: FMA:84638 is_a: CL:0000063 ! cell by histology is_a: CL:0000610 ! plant cell [Term] id: CL:0000669 name: pericyte cell alt_id: CL:0000184 def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:tfm, ISBN:0721662544] synonym: "adventitial cell" EXACT [] synonym: "adventitial reticular cell" EXACT [] synonym: "Cell of Rouget" EXACT [] synonym: "pericyte" EXACT [] synonym: "Pericyte of Rouget" EXACT [] xref: FMA:63174 xref: FMA:84639 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000670 name: primordial germ cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] synonym: "Gonocyte" EXACT [] synonym: "Primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 ! germ line cell is_a: CL:0000219 ! motile cell [Term] id: CL:0000671 name: centripetally migrating follicle cell xref: FBbt:00004906 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000672 name: tracheary element def: "A water conducting cell, tracheid or vessel member." [ISBN:0471245208] is_a: CL:0000610 ! plant cell is_a: CL:0000627 ! transporting cell [Term] id: CL:0000673 name: Kenyon cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000674 name: interfollicle cell synonym: "fly stalk cell" EXACT [] xref: FBbt:00004910 is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000675 name: female gamete def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000676 name: cap cell is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000677 name: gut absorptive cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb] is_a: CL:0000212 ! absorptive cell [Term] id: CL:0000678 name: commisural neuron is_a: CL:0000372 ! tormogen cell [Term] id: CL:0000679 name: glutamatergic neuron is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000680 name: muscle precursor cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000681 name: radial glial cell def: "A transient cell present only in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000682 name: M cell def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [GOC:jb, GOC:tfm] synonym: "M-cell" EXACT [] synonym: "microfold cell" EXACT [] xref: FMA:62929 is_a: CL:0000066 ! epithelial cell is_a: CL:0000473 ! defensive cell is_a: CL:0000627 ! transporting cell [Term] id: CL:0000683 name: ependymoglial cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [http://neurolex.org/wiki/Category\:Ependymoglial_Cell, JB:jb] synonym: "Ependymal astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000684 name: littoral cell of liver is_a: CL:0000077 ! mesothelial cell [Term] id: CL:0000685 name: meristematic cell def: "A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010] is_a: CL:0000610 ! plant cell [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000151 ! secretory cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0000687 name: R1 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000688 name: perijunctional fibroblast def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb] is_a: CL:0000057 ! fibroblast is_a: CL:0000630 ! supportive cell [Term] id: CL:0000689 name: myoendocrine cell def: "A cell with both myofibrils and secretory granules." [JB:jb] is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000690 name: R2 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000691 name: stellate interneuron is_a: CL:0000099 ! interneuron [Term] id: CL:0000692 name: terminal Schwann cell def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb, PMID:16136171] is_a: CL:0000630 ! supportive cell is_a: CL:0002376 ! non-myelinating Schwann cell [Term] id: CL:0000693 name: neuroglioform cell def: "A stellate interneuron having 7-10 dendrites that may branch." [JB:jb] synonym: "spiderweb cell" EXACT [] is_a: CL:0000691 ! stellate interneuron [Term] id: CL:0000694 name: R3 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000695 name: Cajal-Retzius cell def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000696 name: PP cell def: "A cell that stores and secretes pancreatic polypeptides." [GOC:tfm, JB:jb, PMID:15153415] synonym: "Type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000697 name: R4 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000698 name: paraganglial cell is_obsolete: true [Term] id: CL:0000699 name: paraganglial type 1 cell is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000700 name: dopaminergic neuron def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill] synonym: "Dopaminergic cell" EXACT [] xref: FMA:84787 is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0000701 name: paraganglia type 2 cell def: "Supports paraganglial type 1 cell." [JB:jb] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000702 name: R5 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000703 name: sustentacular cell def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000704 name: endothelial tip cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0000705 name: R6 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000706 name: choroid plexus epithelial cell def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000627 ! transporting cell [Term] id: CL:0000707 name: R7 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000494 ! UV sensitive photoreceptor cell [Term] id: CL:0000708 name: leptomeningeal cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb] synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000709 name: R8 photoreceptor cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000710 name: neurecto-epithelial cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm, http://63.198.234.228/OpenFMA/Neurecto-epithelial cell.html] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000711 name: cumulus cell is_a: CL:0000154 ! protein secreting cell relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000712 name: stratum granulosum cell is_a: CL:0000362 ! epidermal cell [Term] id: CL:0000713 name: corona radiata cell is_a: CL:0000711 ! cumulus cell [Term] id: CL:0000715 name: embryonic crystal cell is_a: CL:0000392 ! crystal cell is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000717 name: fusimotor neuron def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000718 name: cone cell (sensu Endopterygota) is_a: CL:0000306 ! crystallin accumulating cell [Term] id: CL:0000719 name: posterior cone cell (sensu Endopterygota) is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000720 name: anterior cone cell (sensu Endopterygota) is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000721 name: equatorial cone cell (sensu Endopterygota) is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000722 name: cystoblast is_a: CL:0000586 ! germ cell [Term] id: CL:0000723 name: somatic stem cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: FMA:63368 is_a: CL:0000034 ! stem cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000724 name: heterocyst def: " A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma] is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell is_a: CL:0000144 ! cell by function [Term] id: CL:0000726 name: chlamydospore def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [GOC:tfm, ISBN:085199377X] comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. is_a: CL:0000605 ! asexual spore [Term] id: CL:0000727 name: primary pigment cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000728 name: secondary pigment cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000729 name: tertiary pigment cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000730 name: leading edge cell def: "A cell at the front of a migrating epithelial sheet." [MA:ma] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000731 name: urothelial cell def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [GOC:tfm, MA:ma] synonym: "Bladder transitional cell" EXACT [] synonym: "Transitional epithelial cell of urinary bladder" EXACT [] synonym: "Urinary tract transitional epithelial cell" EXACT [] xref: FMA:84127 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000732 name: amoeboid cell is_a: CL:0000219 ! motile cell [Term] id: CL:0000733 name: lymph gland plasmatocyte is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000734 name: embryonic gland plasmatocyte is_a: CL:0000394 ! plasmatocyte is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000735 name: lymph gland hemocyte is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000736 name: embryonic gland hemocyte is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000737 name: striated muscle cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: FMA:86936 is_a: CL:0000187 ! muscle cell [Term] id: CL:0000738 name: leukocyte def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] synonym: "immune cell" EXACT [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: FMA:62852 is_a: CL:0000219 ! motile cell is_a: CL:0000988 ! hematopoietic cell relationship: develops_from CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000740 name: retinal ganglion cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" EXACT [] xref: FMA:67765 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000741 name: spinal accessory motor neuron def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219] synonym: "SACMN" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000742 name: periarticular chondrocyte def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000743 name: hypertrophic chondrocyte def: "A terminally differentiated chondrocyte that differentiates in the late embryonic growth plate of bone." [PMID:15951842] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000744 name: columnar chondrocyte def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000745 name: horizontal cell def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433] is_a: CL:0000099 ! interneuron [Term] id: CL:0000746 name: cardiac muscle cell def: "A myocyte located in the heart. The contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:tfm, ISBN:0323052908] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] xref: FMA:14067 xref: FMA:83808 is_a: CL:0000737 ! striated muscle cell relationship: develops_from CL:0000513 ! cardiac muscle myoblast [Term] id: CL:0000747 name: cyanophore def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl] synonym: "blue chromatophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005005 ! cyanoblast [Term] id: CL:0000748 name: retinal bipolar neuron def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000103 ! bipolar neuron [Term] id: CL:0000749 name: ON-bipolar cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000750 name: OFF-bipolar cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000751 name: rod bipolar cell def: "A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [GOC:tfm, PMID:14689473] xref: FMA:67750 is_a: CL:0000748 ! retinal bipolar neuron is_a: CL:0000749 ! ON-bipolar cell [Term] id: CL:0000752 name: cone retinal bipolar cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000753 name: type 1 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473] synonym: "DB1 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000754 name: type 2 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1." [PMID:14689473] synonym: "FMB cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000755 name: type 3 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB2 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000756 name: type 4 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB3 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000757 name: type 5 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473] synonym: "DB4 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000758 name: type 6 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473] synonym: "DB5 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000759 name: type 7 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473] synonym: "IMB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000760 name: type 8 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473] synonym: "DB6 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000761 name: type 9 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473] synonym: "BB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000762 name: thrombocyte def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205] comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. is_a: CL:0000224 ! cell by nuclear number is_a: CL:0000763 ! myeloid cell relationship: develops_from CL:0000828 ! thromboblast [Term] id: CL:0000763 name: myeloid cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell alt_id: CL:0002156 def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] synonym: "erythropoietic cell" EXACT [] xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell disjoint_from: CL:0000556 ! megakaryocyte [Term] id: CL:0000765 name: erythroblast def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] synonym: "normoblast" EXACT [] xref: FMA:83504 is_a: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000547 ! proerythroblast [Term] id: CL:0000766 name: myeloid leukocyte def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] is_a: CL:0000738 ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMID:11927641, PMID:19114669, PMID:19741522, PMID:9933081] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: FMA:62862 is_a: CL:0000094 ! granulocyte [Term] id: CL:0000768 name: immature basophil def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 ! basophil relationship: develops_from CL:0000830 ! basophilic promyelocyte [Term] id: CL:0000769 name: basophilic metamyelocyte def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [GOC:tfm, ISBN:0721601464, PMID:18466030] xref: FMA:84198 is_a: CL:0000768 ! immature basophil is_a: CL:0002192 ! metamyelocyte relationship: develops_from CL:0000614 ! basophilic myelocyte [Term] id: CL:0000770 name: band form basophil def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, http://www.cap.org, ISBN:0721601464, PMID:18466030] is_a: CL:0000768 ! immature basophil relationship: develops_from CL:0000769 ! basophilic metamyelocyte [Term] id: CL:0000771 name: eosinophil def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMID:10914487, PMID:1662676, PMID:19114669] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Ussually considered CD16-negative, CD16 is observed on eosionophilic metamyelocyte. synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: FMA:62861 is_a: CL:0000094 ! granulocyte [Term] id: CL:0000772 name: immature eosinophil def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 ! eosinophil relationship: develops_from CL:0000833 ! eosinophilic promyelocyte [Term] id: CL:0000773 name: eosinophilic metamyelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 ! immature eosinophil is_a: CL:0002192 ! metamyelocyte relationship: develops_from CL:0000612 ! eosinophilic myelocyte [Term] id: CL:0000774 name: band form eosinophil def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 ! immature eosinophil relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte [Term] id: CL:0000775 name: neutrophil def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: FMA:62860 is_a: CL:0000094 ! granulocyte [Term] id: CL:0000776 name: immature neutrophil def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 ! neutrophil relationship: develops_from CL:0000564 ! neutrophilic promyelocyte [Term] id: CL:0000777 name: mesangial phagocyte def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000778 name: mononuclear osteoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000224 ! cell by nuclear number [Term] id: CL:0000779 name: multinuclear osteoclast def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 ! osteoclast is_a: CL:0000224 ! cell by nuclear number relationship: develops_from CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: multinucleated, highly vesicular; location: roots of decidious (milk) teeth. synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast relationship: develops_from CL:0000781 ! mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: Mononuclear, highly vesicular; location: roots of decidious (milk) teeth. is_a: CL:0000588 ! odontoclast is_a: CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000782 name: myeloid dendritic cell def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:9521319] synonym: "interdigitating cell" BROAD [] synonym: "veiled cell" BROAD [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0000576 ! monocyte [Term] id: CL:0000783 name: multinucleated phagocyte def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000224 ! cell by nuclear number is_a: CL:0000518 ! phagocyte (sensu Vertebrata) [Term] id: CL:0000784 name: plasmacytoid dendritic cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, PMID:15549123, PMID:15596797, PMID:20304825] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] is_a: CL:0000451 ! dendritic cell relationship: develops_from CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000785 name: mature B cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, ISBN:0781735149] synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000236 ! B cell disjoint_from: CL:0000816 ! immature B cell disjoint_from: CL:0000817 ! precursor B cell disjoint_from: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000818 ! transitional stage B cell [Term] id: CL:0000786 name: plasma cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, ISBN:0721601464, ISBN:0781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003. 781735149"] synonym: "plasmacyte" EXACT [] xref: FMA:70574 is_a: CL:0000946 ! antibody secreting cell relationship: develops_from CL:0000980 ! plasmablast [Term] id: CL:0000787 name: memory B cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:rhs, ISBN:0781735149] synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000788 name: naive B cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:rhs, ISBN:0781765196] synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: develops_from CL:0000818 ! transitional stage B cell [Term] id: CL:0000789 name: alpha-beta T cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 ! T cell disjoint_from: CL:0000798 ! gamma-delta T cell [Term] id: CL:0000790 name: immature alpha-beta T cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002420 ! immature T cell [Term] id: CL:0000791 name: mature alpha-beta T cell def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002419 ! mature T cell relationship: develops_from CL:0000790 ! immature alpha-beta T cell [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] comment: Note that while T cels of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "Killer T cell" EXACT [] synonym: "Killer T lymphocyte" EXACT [] xref: FMA:70573 is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 ! mature alpha-beta T cell [Term] id: CL:0000798 name: gamma-delta T cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 ! T cell [Term] id: CL:0000799 name: immature gamma-delta T cell def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002420 ! immature T cell relationship: develops_from CL:0000807 ! DN3 thymocyte [Term] id: CL:0000800 name: mature gamma-delta T cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002419 ! mature T cell relationship: develops_from CL:0000799 ! immature gamma-delta T cell [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 ! mature gamma-delta T cell [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell [Term] id: CL:0000805 name: immature single positive thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000808 ! DN4 thymocyte [Term] id: CL:0000806 name: DN2 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "Double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell [Term] id: CL:0000807 name: DN3 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000806 ! DN2 thymocyte [Term] id: CL:0000808 name: DN4 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "T.DN4.th" EXACT [] is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000807 ! DN3 thymocyte [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Thymocytes of this stage are undergoing positive and negative selection. synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000805 ! immature single positive thymocyte [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000813 name: memory T cell def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell disjoint_from: CL:0000898 ! naive T cell [Term] id: CL:0000814 name: mature NK T cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell relationship: develops_from CL:0002042 ! immature NK T cell stage IV [Term] id: CL:0000815 name: regulatory T cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T cell" EXACT [] synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0002419 ! mature T cell [Term] id: CL:0000816 name: immature B cell def: "An immature B cell is a precursor B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B Cell" EXACT [ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0000954 ! small pre-B-II cell [Term] id: CL:0000817 name: precursor B cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm] synonym: "pre-B cell" EXACT [] is_a: CL:0000236 ! B cell [Term] id: CL:0000818 name: transitional stage B cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111] synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0000236 ! B cell relationship: develops_from CL:0000816 ! immature B cell [Term] id: CL:0000819 name: B-1 B cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, http://www.immgen.org/index_content.html, PMID:11861604] synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000820 name: B-1a B cell def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] is_a: CL:0000819 ! B-1 B cell [Term] id: CL:0000821 name: B-1b B cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] is_a: CL:0000819 ! B-1 B cell [Term] id: CL:0000822 name: B-2 B cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:11861604] synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "follicular B cell" RELATED [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000823 name: immature natural killer cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000623 ! natural killer cell disjoint_from: CL:0000824 ! mature natural killer cell relationship: develops_from CL:0000937 ! pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782] synonym: "LAK cell" BROAD [PMID:14685782] synonym: "lymphokine activated killer cell" BROAD [PMID:14685782] synonym: "mature NK cell" EXACT [] synonym: "NK.sp" EXACT [] is_a: CL:0000623 ! natural killer cell relationship: develops_from CL:0000823 ! immature natural killer cell [Term] id: CL:0000825 name: pro-NK cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674] comment: Most markers only described for human pro NK cells. synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674] synonym: "null cell" RELATED [PMID:11532393] synonym: "preNK cell" RELATED [PMID:11532393] synonym: "pro-natural killer cell" EXACT [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell relationship: develops_from CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000826 name: pro-B cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, ISBN:0781735149, PMID:12633665] synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] synonym: "Pre-pro B cell" BROAD [PMID:17582343] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell disjoint_from: CL:0000817 ! precursor B cell relationship: develops_from CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000827 name: pro-T cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell relationship: develops_from CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000828 name: thromboblast def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949] comment: Note that this is a non-mammalian cell type. is_a: CL:0000224 ! cell by nuclear number is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000829 name: basophilic myeloblast def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 ! myeloblast relationship: develops_from CL:0000613 ! basophil progenitor cell [Term] id: CL:0000830 name: basophilic promyelocyte def: "A promyelocyte committed to the basophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84208 is_a: CL:0000836 ! promyelocyte relationship: develops_from CL:0000829 ! basophilic myeloblast [Term] id: CL:0000831 name: mast cell progenitor def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMID:16006518, PMID:16330751, PMID:8629001, PMID:9354811] comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. synonym: "CFU-Mast " RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0002028 ! basophil mast progenitor cell [Term] id: CL:0000832 name: eosinophilic myeloblast def: "A myeloblast committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 ! myeloblast relationship: develops_from CL:0000611 ! eosinophil progenitor cell [Term] id: CL:0000833 name: eosinophilic promyelocyte def: "A promyelocyte committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84199 is_a: CL:0000836 ! promyelocyte relationship: develops_from CL:0000832 ! eosinophilic myeloblast [Term] id: CL:0000834 name: neutrophil progenitor cell def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000835 name: myeloblast def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://www.cap.org, ISBN:0721601464] xref: FMA:83524 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000836 name: promyelocyte def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [GOC:add, GOC:amm, GOC:tfm, http://www.cap.org, ISBN:0721601464] xref: FMA:83530 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000835 ! myeloblast [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] is_a: CL:0000988 ! hematopoietic cell disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: develops_from CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "lymphoid progenitor cell" BROAD [] xref: FMA:70338 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "myeloid progenitor cell" BROAD [] xref: FMA:70339 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell disjoint_from: CL:0000838 ! lymphoid lineage restricted progenitor cell [Term] id: CL:0000840 name: immature conventional dendritic cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [GOC:add, GOC:tfm, PMID:9521319] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0001029 ! common dendritic progenitor [Term] id: CL:0000841 name: mature conventional dendritic cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, GOC:tfm, PMID:9521319] synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0000840 ! immature conventional dendritic cell [Term] id: CL:0000842 name: mononuclear cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "Peripheral blood mononuclear cell" NARROW [] xref: FMA:86713 is_a: CL:0000224 ! cell by nuclear number is_a: CL:0000738 ! leukocyte is_a: CL:0002087 ! nongranular leukocyte [Term] id: CL:0000843 name: follicular B cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:add, http://www.immgen.org/index_content.html, ISBN:0781735149, PMID:12515816] synonym: "Fo B cell" EXACT [] is_a: CL:0000785 ! mature B cell is_a: CL:0000822 ! B-2 B cell [Term] id: CL:0000844 name: germinal center B cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] is_a: CL:0000785 ! mature B cell relationship: develops_from CL:0000843 ! follicular B cell [Term] id: CL:0000845 name: marginal zone B cell def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD23-negative, CD21/35-high." [GOC:add, http://www.immgen.org/index_content.html, ISBN:0781735149, PMID:10933592] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000846 name: vestibular dark cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000847 name: ciliated olfactory receptor neuron def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163] synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000848 name: microvillous olfactory receptor neuron def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163] synonym: "microvillous olfactory sensory neuron" EXACT [] synonym: "microvillous sensory neuron" RELATED [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000849 name: crypt olfactory receptor neuron def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163] synonym: "crypt cell" EXACT [] synonym: "crypt olfactory sensory neuron" EXACT [] synonym: "crypt sensory neuron" EXACT [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000850 name: serotonergic neuron alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: FBbt:00005133 is_a: CL:0000540 ! neuron [Term] id: CL:0000851 name: neuromast mantle cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000852 name: neuromast support cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000853 name: olfactory epithelial support cell def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl] synonym: "olfactory sustentacular cell" EXACT [] synonym: "Supporting cell of olfactory epithelium" EXACT [] synonym: "Sustentaculocyte of olfactory epithelium" EXACT [] xref: FMA:62302 is_a: CL:0000630 ! supportive cell is_a: CL:0002167 ! olfactory epithelial cell [Term] id: CL:0000854 name: interneuromast cell def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl] is_a: CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000032 ! neuroplacodal cell [Term] id: CL:0000855 name: hair cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl] is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl] is_a: CL:0000855 ! hair cell [Term] id: CL:0000857 name: slow muscle myoblast def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000858 name: fast muscle myoblast def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000859 name: cementum secreting cell def: "A secretory cell that secretes cementum, a bony substance that covers the root of a tooth." [SANBI:mhl] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000860 name: inflammatory monocyte def: "A type of monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors. This cell type is characterized by high expression of CCR2 in both rodents and humans, and of being larger size than non-classical monocytes." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). synonym: "classical monocyte" EXACT [] is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000576 ! monocyte [Term] id: CL:0000861 name: elicited macrophage def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 ! macrophage relationship: develops_from CL:0000860 ! inflammatory monocyte [Term] id: CL:0000862 name: suppressor macrophage def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 ! elicited macrophage [Term] id: CL:0000863 name: inflammatory macrophage def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana, PMID:19132917] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage [Term] id: CL:0000864 name: tissue-resident macrophage def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 ! macrophage [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage [Term] id: CL:0000866 name: thymic macrophage def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000867 name: secondary lymphoid organ macrophage def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865] comment: Marker was observed on rat cells. is_a: CL:0000867 ! secondary lymphoid organ macrophage [Term] id: CL:0000869 name: tonsillar macrophage def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage [Term] id: CL:0000870 name: Peyer's patch macrophage def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage [Term] id: CL:0000871 name: splenic macrophage def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 is_a: CL:0000867 ! secondary lymphoid organ macrophage [Term] id: CL:0000872 name: splenic marginal zone macrophage def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 ! splenic macrophage [Term] id: CL:0000873 name: splenic metallophillic macrophage def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. is_a: CL:0000871 ! splenic macrophage [Term] id: CL:0000874 name: splenic red pulp macrophage def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. is_a: CL:0000871 ! splenic macrophage [Term] id: CL:0000875 name: patrolling monocyte def: "Subset of monocytes characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, but increased co-stimulatory activity. May also play a role in tissue repair." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. synonym: "non-classical monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 ! monocyte [Term] id: CL:0000876 name: splenic white pulp macrophage def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597] comment: markers: Mouse: F4/80-, CD68+, macrosialin+. is_a: CL:0000871 ! splenic macrophage [Term] id: CL:0000877 name: splenic tingible body macrophage def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000876 ! splenic white pulp macrophage [Term] id: CL:0000878 name: central nervous system macrophage def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000879 name: meningeal macrophage def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:11591794] is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000880 name: choroid-plexus macrophage def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:9550136] is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000881 name: perivascular macrophage def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000882 name: thymic medullary macrophage def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana, PMID:9048205] is_a: CL:0000866 ! thymic macrophage [Term] id: CL:0000883 name: thymic cortical macrophage def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] is_a: CL:0000866 ! thymic macrophage [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19906191] is_a: CL:0000867 ! secondary lymphoid organ macrophage [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana, PMID:19906191] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [GO_REF:0000031, GOC:tfm, PMID:14668803, PMID:17934446, PMID:20228797] is_a: CL:0000868 ! lymph node macrophage [Term] id: CL:0000888 name: lymph node tingible body macrophage def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000868 ! lymph node macrophage [Term] id: CL:0000889 name: myeloid suppressor cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000890 name: alternatively activated macrophage def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:20510870] comment: Role or process: tissue remodeling. synonym: "M2 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage [Term] id: CL:0000891 name: foam cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] xref: FMA:83586 is_a: CL:0000063 ! cell by histology [Term] id: CL:0000892 name: smooth muscle cell derived foam cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000192 ! smooth muscle cell [Term] id: CL:0000893 name: thymocyte def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: FMA:72202 is_a: CL:0002420 ! immature T cell [Term] id: CL:0000894 name: DN1 thymic pro-T cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 ! pro-T cell relationship: develops_from CL:0002425 ! early T lineage precursor [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [GOC:tfm] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122- high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000898 name: naive T cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell [Term] id: CL:0000899 name: T-helper 17 cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875] synonym: "helper T cell type 17" EXACT [] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Additional markers in human are CD45RA. This cell traffics in secondary lymphoid organs and blood. synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte [Term] id: CL:0000901 name: Tr1 cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000902 name: induced T-regulatory cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: CL:0000903 name: natural T-regulatory cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell [Term] id: CL:0000907 name: central memory CD8 positive, alpha-beta T cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122- high." [GO_REF:0000031, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000910 name: cytotoxic T cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: FMA:70573 is_a: CL:0000911 ! effector T cell [Term] id: CL:0000911 name: effector T cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell [Term] id: CL:0000912 name: helper T cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] is_a: CL:0000911 ! effector T cell [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720] synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell [Term] id: CL:0000914 name: immature NK T cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte [Term] id: CL:0000916 name: dendritic epidermal T cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor [Term] id: CL:0000917 name: Tc1 cell def: "A CD8-positive, alpha-beta positive T cell expressing T-bet and eomesodermin and secreting interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, PMID:9914231] synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] xref: FMA:84793 is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell [Term] id: CL:0000918 name: Tc2 cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:9914231] synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] xref: FMA:84794 is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000921 name: type I NK T cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell [Term] id: CL:0000922 name: type II NK T cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell [Term] id: CL:0000923 name: CD4-positive type I NK T cell def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000921 ! type I NK T cell [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18997862] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 ! type I NK T cell [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000921 ! type I NK T cell is_a: CL:0000923 ! CD4-positive type I NK T cell relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000921 ! type I NK T cell is_a: CL:0000923 ! CD4-positive type I NK T cell relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000921 ! type I NK T cell is_a: CL:0000923 ! CD4-positive type I NK T cell relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000921 ! type I NK T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000921 ! type I NK T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000921 ! type I NK T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000931 name: activated type II NK T cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 ! type II NK T cell [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, PMID:17964217] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 ! type II NK T cell relationship: develops_from CL:0000931 ! activated type II NK T cell [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 ! type II NK T cell relationship: develops_from CL:0000931 ! activated type II NK T cell [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18440213] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000936 name: early lymphoid progenitor def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "ELP" EXACT [] synonym: "GMLP" RELATED [PMID:18371378] synonym: "LMPP" EXACT [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell [Term] id: CL:0000937 name: pre-natural killer cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17100874] synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell disjoint_from: CL:0000823 ! immature natural killer cell disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell [Term] id: CL:0000938 name: CD56-bright cytokine secreting natural killer cell def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19796267] comment: markers are associatied with human cell types. synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell disjoint_from: CL:0000939 ! cytotoxic CD56-dim natural killer cell [Term] id: CL:0000939 name: cytotoxic CD56-dim natural killer cell def: "A mature natural killer cell that has the phenotype CD56-low and CD16-positive and is capable of cytotoxic function and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19796267] comment: This population is mainly found in human. synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell [Term] id: CL:0000940 name: mucosal invariant T cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19416870] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell [Term] id: CL:0000941 name: thymic conventional dendritic cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629] comment: In the mouse this cell expresses CD8-alpha-alpha. is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119] is_a: CL:0000784 ! plasmacytoid dendritic cell relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell [Term] id: CL:0000943 name: Be1 Cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 ! Be cell [Term] id: CL:0000944 name: Be2 cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 ! Be cell [Term] id: CL:0000945 name: lymphocyte of B lineage def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plamsablasts and plasma cells). is_a: CL:0000542 ! lymphocyte relationship: develops_from CL:0000826 ! pro-B cell [Term] id: CL:0000946 name: antibody secreting cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003. 781735149"] is_a: CL:0000945 ! lymphocyte of B lineage [Term] id: CL:0000947 name: IgE plasma cell def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000948 name: IgE memory B cell def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0000949 name: IgD plasmablast def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000950 name: IgE plasmablast def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000951 name: IgE short lived plasma cell def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 ! large pre-B-II cell [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 ! large pre-B-II cell [Term] id: CL:0000954 name: small pre-B-II cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000955 ! pre-B-II cell [Term] id: CL:0000955 name: pre-B-II cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] synonym: "pre-B-lymphocyte" EXACT [] is_a: CL:0000817 ! precursor B cell disjoint_from: CL:0000956 ! pre-B-I cell relationship: develops_from CL:0000826 ! pro-B cell [Term] id: CL:0000956 name: pre-B-I cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] synonym: "Pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0000826 ! pro-B cell [Term] id: CL:0000957 name: large pre-B-II cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:rhs, PMID:9785673] synonym: "Large Pre-B cell" BROAD [PMID:11244048] is_a: CL:0000955 ! pre-B-II cell [Term] id: CL:0000958 name: T1 B cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12515816, PMID:12810111] is_a: CL:0000818 ! transitional stage B cell [Term] id: CL:0000959 name: T2 B cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12515816, PMID:12810111] is_a: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000958 ! T1 B cell [Term] id: CL:0000960 name: T3 B cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121] synonym: "An1 B cell" EXACT [PMID:17174121] is_a: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000959 ! T2 B cell [Term] id: CL:0000961 name: Bm1 B cell def: "A follicular B cell that expresses IgD, but not CD23 or CD38. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:msz, PMID:17992590, PMID:8006591] is_a: CL:0000843 ! follicular B cell relationship: develops_from CL:0000818 ! transitional stage B cell [Term] id: CL:0000962 name: Bm2 B cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:msz, PMID:17992590, PMID:8006591] is_a: CL:0000843 ! follicular B cell relationship: develops_from CL:0000961 ! Bm1 B cell [Term] id: CL:0000963 name: Bm3-delta B cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752] is_a: CL:0000844 ! germinal center B cell relationship: develops_from CL:0000965 ! Bm3 B cell [Term] id: CL:0000964 name: Bm2' B cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:17992590, PMID:8006591] synonym: "Bm2-prime B cell" EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 ! germinal center B cell relationship: develops_from CL:0000962 ! Bm2 B cell [Term] id: CL:0000965 name: Bm3 B cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:msz, PMID:8006591] synonym: "centroblast" RELATED [PMID:8006591] is_a: CL:0000844 ! germinal center B cell relationship: develops_from CL:0000964 ! Bm2' B cell [Term] id: CL:0000966 name: Bm4 B cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:msz, PMID:8006591] synonym: "centrocyte" RELATED [PMID:17992590] is_a: CL:0000844 ! germinal center B cell relationship: develops_from CL:0000963 ! Bm3-delta B cell [Term] id: CL:0000967 name: Bm5 B cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:8006591] is_a: CL:0000787 ! memory B cell relationship: develops_from CL:0000966 ! Bm4 B cell [Term] id: CL:0000968 name: Be cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000969 name: regulatory B cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11869683] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000970 name: unswitched memory B cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive and/or IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:rhs, ISBN:0781765196 "Fundamental Immunology (ed. W.E. Paul)"] is_a: CL:0000787 ! memory B cell relationship: develops_from CL:0000980 ! plasmablast [Term] id: CL:0000971 name: IgM memory B cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] is_a: CL:0000970 ! unswitched memory B cell [Term] id: CL:0000972 name: class switched memory B cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are usually CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] is_a: CL:0000787 ! memory B cell relationship: develops_from CL:0000970 ! unswitched memory B cell [Term] id: CL:0000973 name: IgA memory B cell def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:msz, ISBN:0781765196] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0000974 name: long lived plasma cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190 "Fundamental Immunology, 6ed (Paul,ed), 2003", PMID:16014527] is_a: CL:0000786 ! plasma cell relationship: develops_from CL:0000975 ! short lived plasma cell [Term] id: CL:0000975 name: short lived plasma cell def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527] is_a: CL:0000786 ! plasma cell relationship: develops_from CL:0000980 ! plasmablast [Term] id: CL:0000976 name: IgA short lived plasma cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003. 781735149"] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000977 name: IgG short lived plasma cell def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000978 name: IgM short lived plasma cell def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000979 name: IgG memory B cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0000980 name: plasmablast def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:19059880] xref: FMA:84371 is_a: CL:0000785 ! mature B cell is_a: CL:0000946 ! antibody secreting cell relationship: develops_from CL:0000785 ! mature B cell [Term] id: CL:0000981 name: double negative memory B cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm] is_a: CL:0000787 ! memory B cell [Term] id: CL:0000982 name: IgG plasmablast def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000983 name: IgM plasmablast def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000984 name: IgA plasmablast def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000985 name: IgG plasma cell def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000986 name: IgM plasma cell def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000987 name: IgA plasma cell def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000988 name: hematopoietic cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: FMA:70366 xref: FMA:83598 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte is CD11c-low, CD45R-positive, GR1-positive and is CD11b-negative, CD3-negative, CD34-negative, CD56-negative, and CD19-negative." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000001 )(PMID: 19243617). is_a: CL:0000784 ! plasmacytoid dendritic cell [Term] id: CL:0000990 name: conventional dendritic cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high, CD19-negative, CD3-negative, CD34-negative, and CD56-negative." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL: 0000003)(PMID: 19243617). synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 ! dendritic cell [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD19-negative, CD3-negative, CD34-negative, CD56-negative and is CD123-positive, CD303-positive, CD45RA-positive, and ILT7-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000004 )(PMID: 19243617). synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 ! plasmacytoid dendritic cell [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL: 0000006)(PMID: 19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell relationship: develops_from CL:0001029 ! common dendritic progenitor [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000007 )(PMID: 19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000008 )(PMID: 19243617). is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1100000 )(PMID: 19243617). synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000009 )(PMID: 19243617). is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell [Term] id: CL:0000997 name: immature CD8_alpha-negative CD11b-positive dendritic cell def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000010 )(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 ! CD8_alpha-negative CD11b-positive dendritic cell relationship: develops_from CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0000998 name: CD8_alpha-negative CD11b-negative dendritic cell def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL: 0000011)(PMID: 19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0000999 name: CD8_alpha-negative CD11b-positive dendritic cell def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: Defined as having a disposition to secreting anti-inflammatory cytokines.\nThese markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL: 0000012)(PMID: 19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0001000 name: CD8_alpha-positive CD11b-negative dendritic cell def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: Cells are defined as having a dispostion to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID: 19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell relationship: develops_from CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0001001 name: immature CD8_alpha-negative CD11b-negative dendritic cell def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:DC_CL:0000014)(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell relationship: develops_from CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0001002 name: mature CD8_alpha-negative CD11b-negative dendritic cell def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell [Term] id: CL:0001003 name: mature CD8_alpha-negative CD11b-positive dendritic cell def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 ! CD8_alpha-negative CD11b-positive dendritic cell relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell [Term] id: CL:0001004 name: immature CD8_alpha-positive CD11b-negative dendritic cell def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell relationship: develops_from CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0001005 name: mature CD8_alpha-positive CD11b-negative dendritic cell def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell [Term] id: CL:0001006 name: dermal dendritic cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and is CD8_alpha-negative." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID: 19243617). is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0001007 name: interstitial dendritic cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID: 19243617). is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID: 19243617). synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 ! hematopoietic stem cell [Term] id: CL:0001009 name: immature dermal dendritic cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 ! dermal dendritic cell relationship: develops_from CL:0001029 ! common dendritic progenitor [Term] id: CL:0001010 name: mature dermal dendritic cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 ! dermal dendritic cell relationship: develops_from CL:0001009 ! immature dermal dendritic cell [Term] id: CL:0001011 name: immature interstitial dendritic cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 ! interstitial dendritic cell relationship: develops_from CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID: 19243617). is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001013 name: mature interstitial dendritic cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 ! interstitial dendritic cell relationship: develops_from CL:0001011 ! immature interstitial dendritic cell [Term] id: CL:0001014 name: CD1a-positive Langerhans cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID: 19243617). is_a: CL:0000453 ! Langerhans cell [Term] id: CL:0001015 name: CD8_alpha-low Langerhans cell def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID: 19243617). is_a: CL:0000453 ! Langerhans cell [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 ! CD1a-positive Langerhans cell [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 ! CD1a-positive Langerhans cell relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell [Term] id: CL:0001018 name: immature CD8_alpha-low Langerhans cell def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:18082389] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID: 19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 ! CD8_alpha-low Langerhans cell relationship: develops_from CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID: 19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001020 name: mature CD8_alpha-low Langerhans cell def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:18082389] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID: 19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 ! CD8_alpha-low Langerhans cell relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:18082389, PMID:19022770] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID: 19243617). synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell [Term] id: CL:0001022 name: CD115-positive monocyte def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID: 19243617). is_a: CL:0000576 ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID: 19243617). synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0000049 ! common myeloid progenitor disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID: 19243617). synonym: "CD133-positive hematopoietic stem cell" NARROW [] xref: FMA:86475 is_a: CL:0000037 ! hematopoietic stem cell disjoint_from: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] comment: Markers are associated with mouse cells. synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor relationship: develops_from CL:0000936 ! early lymphoid progenitor [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMID:16551251, PMID:19114669] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID: 19243617). synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID: 19243617). synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID: 19243617). synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001029 name: common dendritic progenitor def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, M-CSFR-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041)(PMID: 19243617). synonym: "common dendritic precursor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID: 19243617). is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell def: "Granule cell that is part of the cerebellum." [GOC:mah] is_a: CL:0000120 ! granule cell [Term] id: CL:0001032 name: cortical granule cell def: "Granule cell that is part of the cerebral cortex." [GOC:mah] is_a: CL:0000120 ! granule cell [Term] id: CL:0001033 name: hippocampal granule cell def: "Granule cell that is part of the hippocampus." [GOC:mah] is_a: CL:0000120 ! granule cell [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) xref: FBbt:00004230 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] comment: Markers found on mouse cells. is_a: CL:0000038 ! erythroid progenitor cell relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 ! granulocyte monocyte progenitor cell relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor created_by: tmeehan creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] comment: Markers are found on mouse cells. is_a: CL:0000557 ! granulocyte monocyte progenitor cell relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor created_by: tmeehan creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell markers associated with human cells. xref: FMA:83517 is_a: CL:0000038 ! erythroid progenitor cell relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T10:14:30Z [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell surface markers are associated with human cells. is_a: CL:0000547 ! proerythroblast relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T10:31:50Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell created_by: tmeehan creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell created_by: tmeehan creation_date: 2010-01-13T03:43:12Z [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [GOC:tfm, PMID:17582345] comment: Markers are found on mouse cells. is_a: CL:0000611 ! eosinophil progenitor cell relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor created_by: tmeehan creation_date: 2010-01-14T03:25:15Z [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [GOC:tfm, PMID:19114669] comment: Markers are associated with human cells. is_a: CL:0000611 ! eosinophil progenitor cell relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor created_by: tmeehan creation_date: 2010-01-14T03:25:17Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] synonym: "MDP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell relationship: develops_from CL:0001029 ! common dendritic progenitor created_by: tmeehan creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] comment: Markers are associated with mouse cells. synonym: "murine MDP" EXACT [] is_a: CL:0002009 ! macrophage dendritic cell progenitor relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor created_by: tmeehan creation_date: 2010-01-26T02:43:40Z [Term] id: CL:0002012 name: Kit-low proerythroblast def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] comment: Markers are associated with mouse cells. is_a: CL:0000547 ! proerythroblast relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002013 name: GlyA-positive basophillic erythroblast def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers are associated with human cells. is_a: CL:0000549 ! basophilic erythroblast relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast created_by: tmeehan creation_date: 2010-04-26T10:41:15Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 ! basophilic erythroblast relationship: develops_from CL:0002012 ! Kit-low proerythroblast created_by: tmeehan creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 ! polychromatophilic erythroblast relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast created_by: tmeehan creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] comment: Cell surface markers are associated with human cells. is_a: CL:0000550 ! polychromatophilic erythroblast relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast created_by: tmeehan creation_date: 2010-04-26T10:53:16Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 ! orthochromatic erythroblast relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast created_by: tmeehan creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers associated with human cells. is_a: CL:0000552 ! orthochromatic erythroblast relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast created_by: tmeehan creation_date: 2010-04-26T11:04:21Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294] comment: Marker associated with mouse cells. is_a: CL:0002422 ! enucleated reticulocyte relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts created_by: tmeehan creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002020 name: GlyA-positive reticulocytes def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers is associated with human cells. is_a: CL:0002422 ! enucleated reticulocyte relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast created_by: tmeehan creation_date: 2010-04-26T11:48:25Z [Term] id: CL:0002021 name: GlyA-positive erythrocyte def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094] comment: Marker is associated with human cell types. is_a: CL:0000595 ! enucleate erythrocyte relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes created_by: tmeehan creation_date: 2010-04-26T11:51:22Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte def: "An enucleated erythorcyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084] comment: Marker is associated with mouse cell types. is_a: CL:0000595 ! enucleate erythrocyte relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte created_by: tmeehan creation_date: 2010-04-26T11:51:27Z [Term] id: CL:0002023 name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are associated with human cell type. is_a: CL:0000553 ! megakaryocyte progenitor cell relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell created_by: tmeehan creation_date: 2010-04-26T02:39:09Z [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553] comment: Markers are associated with mouse cells. is_a: CL:0000553 ! megakaryocyte progenitor cell relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T02:39:15Z [Term] id: CL:0002025 name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000553 ! megakaryocyte progenitor cell relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell created_by: tmeehan creation_date: 2010-04-26T03:52:47Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated wtih human cells. is_a: CL:0000556 ! megakaryocyte relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell created_by: tmeehan creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm] comment: Markers are commonly associated with mouse cells. is_a: CL:0000556 ! megakaryocyte relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell created_by: tmeehan creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002028 name: basophil mast progenitor cell def: "A cell type that can give rise to basophil and mast cells. This cell is Il5r-positive, CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMID:16330751] comment: There may be an intermediate cell type. . These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. They also express microphthalmia-associated transcription factor (mitf) and mast cell protease 1 (mMCP-1). Expression of CEBP/a is low. synonym: "BMCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-04-27T12:46:33Z [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [GOC:tfm, PMID:16330751] is_a: CL:0000831 ! mast cell progenitor relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell created_by: tmeehan creation_date: 2010-04-27T01:22:19Z [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [GOC:tfm, PMID:16330751] comment: Markers are associated with mouse cells. is_a: CL:0000613 ! basophil progenitor cell relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell created_by: tmeehan creation_date: 2010-04-27T01:22:32Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] is_a: CL:0000988 ! hematopoietic cell relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0000988 ! hematopoietic cell disjoint_from: CL:0002031 ! hematopoietic lineage restricted progenitor cell relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Spa-1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "ST stem cell" EXACT [] is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell relationship: develops_from CL:0002034 ! long term hematopoietic stem cell created_by: tmeehan creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Spa-1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] comment: Markers are associated with mouse cells. synonym: "LT stem cell" EXACT [] is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell created_by: tmeehan creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell created_by: tmeehan creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "KSL cell" EXACT [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: develops_from CL:0002033 ! short term hematopoietic stem cell created_by: tmeehan creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002037 name: CD2-positive, CD-5 positive, CD44-positive alpha-beta intraepithelial T cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:tfm, PMID:16048545] synonym: "memory alpha beta IEL" EXACT [PMID:16048545] is_a: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell created_by: tmeehan creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL-6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402] synonym: "T(FH)" EXACT [PMID:20207847] synonym: "Tfh" EXACT [PMID:20383172] is_a: CL:0000492 ! CD4-positive helper T cell relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell created_by: tmeehan creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:17589542] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0002039 ! immature NK T cell stage I created_by: tmeehan creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0002040 ! immature NK T cell stage II created_by: tmeehan creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell relationship: develops_from CL:0002041 ! immature NK T cell stage III created_by: tmeehan creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell created_by: tmeehan creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [GOC:ak, GOC:tfm] comment: Markers are associated with mouse cells. is_a: CL:0002028 ! basophil mast progenitor cell created_by: tmeehan creation_date: 2010-04-27T01:22:38Z [Term] id: CL:0002045 name: Fraction A pre-pro B cell def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343] comment: Markers associated with mouse cells. synonym: "Fraction A" EXACT [] synonym: "Pre pro B cell" RELATED [] is_a: CL:0000826 ! pro-B cell created_by: tmeehan creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: Early pro-B cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and has TdT activity. Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:tfm, PMID:18432934] comment: Markers are commonly associated with human cells. is_a: CL:0000826 ! pro-B cell created_by: tmeehan creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002047 name: Fraction B precursor B cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with mouse cells. synonym: "Fr. B" EXACT [] synonym: "Fraction B" EXACT [] is_a: CL:0002400 ! Fraction B/C precursor B cell relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell created_by: tmeehan creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:tfm, PMID:18432934] is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0002046 ! Early pro-B cell created_by: tmeehan creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: Fraction C precursor B cell def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343] synonym: "Fraction C" RELATED [] is_a: CL:0002400 ! Fraction B/C precursor B cell relationship: develops_from CL:0002047 ! Fraction B precursor B cell created_by: tmeehan creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: Fraction C' precursor B cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343] synonym: "Fr. C'" EXACT [] synonym: "Fraction C-prime" EXACT [] is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0002049 ! Fraction C precursor B cell created_by: tmeehan creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell def: "A pre-BCR positive T cell that is CD38-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cells. synonym: "Large pre-B cell type I" RELATED [] is_a: CL:0000952 ! preBCR-positive large pre-B-II cell relationship: develops_from CL:0002048 ! late pro-B cell created_by: tmeehan creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: Fraction D precursor B cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343] synonym: "Fr. D" EXACT [] synonym: "Fraction D pre-B cell" EXACT [GOC:tfm] is_a: CL:0000817 ! precursor B cell relationship: develops_from CL:0002050 ! Fraction C' precursor B cell created_by: tmeehan creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell def: "A small pre-B cell that is CD22-positive and CD38-low." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell. RAG expression maybe diminishing. synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 ! small pre-B-II cell relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell created_by: tmeehan creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: Fraction E immature B cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:tfm, PMID:17582343] comment: Markers associated with mouse cells. is_a: CL:0000816 ! immature B cell relationship: develops_from CL:0002052 ! Fraction D precursor B cell created_by: tmeehan creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell type. is_a: CL:0000816 ! immature B cell relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell created_by: tmeehan creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: Fraction F mature B cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343] is_a: CL:0000785 ! mature B cell is_a: CL:0000822 ! B-2 B cell relationship: develops_from CL:0002054 ! Fraction E immature B cell created_by: tmeehan creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative monocyte def: "A monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive," [GOC:tfm, PMID:15615263, PMID:1706877, PMID:19689341] comment: Markers are associated with human monocytes. is_a: CL:0000860 ! inflammatory monocyte created_by: tmeehan creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low monocyte def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [GOC:tfm, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. is_a: CL:0000875 ! patrolling monocyte is_a: CL:0001022 ! CD115-positive monocyte relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte created_by: tmeehan creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8alpha-alpha-positive thymic conventional dendritic cell def: "A conventional thymic dendritic cell that is CD8alpha-alpha homodomer-high." [GOC:tfm, PMID:19273629] is_a: CL:0000941 ! thymic conventional dendritic cell created_by: tmeehan creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821] is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and interleukin 4. TH2 cytokine production is surpressed." [GOC:tfm, PMID:18931678, PMID:19604299, PMID:20154671] synonym: "Th9" EXACT [PMID:18931678] is_a: CL:0000492 ! CD4-positive helper T cell created_by: tmeehan creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002062 name: type I pneumocyte def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144] synonym: "AT1" EXACT [] synonym: "ATI" EXACT [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "Pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "Type 1 pneumocyte" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] xref: FMA:62500 is_a: CL:0000322 ! pneumocyte created_by: tmeehan creation_date: 2010-06-23T04:37:54Z [Term] id: CL:0002063 name: type II pneumocyte def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:8540632] synonym: "AT2" EXACT [] synonym: "ATII" EXACT [] synonym: "Cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "Great alveolar cell" EXACT [] synonym: "Lung type 2 cells" EXACT [] synonym: "Lung type II cells" RELATED [] synonym: "TII" EXACT [] synonym: "type 2 alveolar epithelial cells" EXACT [] synonym: "type 2 alveolocytes" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar epithelial cells" EXACT [] synonym: "type II alveolocytes" EXACT [] xref: FMA: 62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte created_by: tmeehan creation_date: 2010-06-24T12:04:13Z [Term] id: CL:0002064 name: pancreatic acinar cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://63.198.234.228/OpenFMA/Acinar cell of pancreas.html, http://www.copewithcytokines.de, ISBN:0517223651, PMID:20395539] synonym: "acinar cell of pancreas" EXACT [] xref: FMA:63032 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000622 ! acinar cell created_by: tmeehan creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] synonym: "Bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] synonym: "P cell" BROAD [] synonym: "respiratory enterochromaffin cell " EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell created_by: tmeehan creation_date: 2010-06-28T08:24:30Z [Term] id: CL:0002067 name: type A enterocrine cell def: "An enterocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell created_by: tmeehan creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] synonym: "Myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002069 name: type II vestibular sensory cell def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651] synonym: "Type 2 vestibular hair cell" EXACT [] synonym: "type 2 vestibular sensory cell" EXACT [] synonym: "Type II hair cell" EXACT [] xref: FMA:67909 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:13Z [Term] id: CL:0002070 name: type I vestibular sensory cell def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651] synonym: "Type 1 vestibular hair cell" EXACT [] synonym: "type 1 vestibular sensory cell" EXACT [] synonym: "Type I hair cell" EXACT [] xref: FMA:62352 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:19Z [Term] id: CL:0002071 name: columnar cell of the colon def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [GOC:tfm, http://63.198.234.228/OpenFMA/Vacuolar absorptive cell.html, ISBN:0517223651] synonym: "columnar cell" EXACT [] synonym: "Vacuolar absorptive cell" EXACT [] xref: FMA:63638 is_a: CL:0000239 ! brush border epithelial cell created_by: tmeehan creation_date: 2010-06-29T11:07:25Z [Term] id: CL:0002072 name: nodal myocyte def: "A specialized cardiac myocyte in the sinuatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm, http://63.198.234.228/OpenFMA/Nodal myocyte.html] synonym: "Myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "Pacemaker cell" EXACT [] xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm, http://63.198.234.228/OpenFMA/Transitional myocyte.html] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell def: "The myoendocrine cells are specialized myocytes localized mainly in the right and left atrial appendages, and are also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm, http://63.198.234.228/OpenFMA/Myocardial endocrine cell.html] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002075 name: brush cell of trachebronchial tree def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." [GOC:tfm, http://63.198.234.228/OpenFMA/Brush cell.html, ISBN:0517223651, PMID:15817800] synonym: "pulmonary brush cell" RELATED [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002204 ! brush cell created_by: tmeehan creation_date: 2010-06-29T03:22:46Z [Term] id: CL:0002076 name: endo-epithelial cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm, http://63.198.234.228/OpenFMA/Endo-epithelial cell.html] xref: FMA:69075 is_a: CL:0000066 ! epithelial cell created_by: tmeehan creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell def: "An epithelial cell derived from ectoderm." [FMA://63.198.234.228/OpenFMA/Ecto-epithelial cell.html, FMA:69074] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell created_by: tmeehan creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm, http://63.198.234.228/OpenFMA/Meso-epithelial cell.html] synonym: "Epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell created_by: tmeehan creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0000083 ! epithelial cell of pancreas created_by: tmeehan creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] synonym: "centroacinar cells of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:0000083 ! epithelial cell of pancreas created_by: tmeehan creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002081 name: type II cell of carotid body def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227] synonym: "sheath cell of carotid body" EXACT [] xref: FMA:84187 is_a: CL:0000703 ! sustentacular cell created_by: tmeehan creation_date: 2010-06-30T04:23:42Z [Term] id: CL:0002082 name: type II cell of adrenal medulla def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm] synonym: "adremergic chromaffin cell" EXACT [] synonym: "adrenal secreting cell of the adrenal medulla" EXACT [] synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrin secreting cell created_by: tmeehan creation_date: 2010-07-14T09:41:42Z [Term] id: CL:0002083 name: type I cell of adrenal medulla def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X] xref: FMA:69321 is_a: CL:0000336 ! adrenal medulla chromaffin cell is_a: CL:0000459 ! norepinephrin secreting cell created_by: tmeehan creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell] synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] synonym: "Bottcher's cell" EXACT [] is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-07-14T03:22:02Z [Term] id: CL:0002085 name: tanycyte alt_id: CL:0000643 def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte] synonym: "stretch cell" EXACT [] synonym: "tanycyte" EXACT [] xref: FMA:54560 is_a: CL:0000683 ! ependymoglial cell created_by: tmeehan creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte def: "A leukocyte that lacks granules." [GOC:tfm] synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 ! leukocyte created_by: tmeehan creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. synonym: "ICC" EXACT [] xref: FMA:86573 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002089 name: nuocyte def: "A leukocyte cell capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:tfm, PMID:20200518] is_a: CL:0000738 ! leukocyte created_by: tmeehan creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002090 name: polar body def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, ISBN:068340007X] xref: FMA:85543 is_a: CL:0000021 ! female germ cell created_by: tmeehan creation_date: 2010-08-23T09:49:53Z [Term] id: CL:0002091 name: primary polar body def: "A small cell formed by the first meiotic division of oocytes." [GOC:tfm, ISBN:068340007X] synonym: "Polocytus primarius" EXACT [] xref: FMA:18650 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:49:58Z [Term] id: CL:0002092 name: bone marrow cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] xref: FMA:83621 is_a: CL:0002320 ! connective tissue cell created_by: tmeehan creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002093 name: secondary polar body def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [GOC:tfm, ISBN:068340007X] synonym: "Polocytus secundarius" EXACT [] xref: FMA:18651 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:50:01Z [Term] id: CL:0002094 name: interstitial cell of ovary def: "A cell that makes up the loose connective tissue of the ovary." [GOC:tfm] xref: FMA:18709 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:11:34Z [Term] id: CL:0002095 name: hilus cell of ovary def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] synonym: "Hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell created_by: tmeehan creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002096 name: internodal tract myocyte def: "A specialised myocyte that lies between the sinuatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300] xref: FMA:223275 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:24:11Z [Term] id: CL:0002097 name: cortical cell of adrenal gland def: "A cell of the adrenal cortex that synthesizes and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm] synonym: "adrenal cortex cell" EXACT [] xref: FMA:69545 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002098 name: regular cardiac myocyte def: "A cardiac myocyte that is connected together by transverse intercalated discs at a regular interval." [GOC:tfm] synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] xref: FMA:67967 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-08-23T11:33:10Z [Term] id: CL:0002099 name: type I cell of adrenal cortex def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651] synonym: "Epithelial cell of zona glomerulosa of adrenal gland" EXACT [] xref: FMA:69273 is_a: CL:0000456 ! mineralocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:42:02Z [Term] id: CL:0002100 name: regular interventricular cardiac myocyte def: "A regular cardiac myocyte of the interventricular region of the heart." [GOC:tfm] xref: FMA:228792 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:40:52Z [Term] id: CL:0002101 name: CD38-positive naive B cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000788 ! naive B cell [Term] id: CL:0002102 name: CD38-negative naive B cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000788 ! naive B cell [Term] id: CL:0002103 name: IgG-positive double negative memory B cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000981 ! double negative memory B cell [Term] id: CL:0002104 name: IgG-negative double negative memory B cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000981 ! double negative memory B cell [Term] id: CL:0002105 name: CD38-positive IgG memory B cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000979 ! IgG memory B cell [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002105 ! CD38-positive IgG memory B cell [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002105 ! CD38-positive IgG memory B cell [Term] id: CL:0002108 name: CD38-negative IgG memory B cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000979 ! IgG memory B cell [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002101 ! CD38-positive naive B cell [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002101 ! CD38-positive naive B cell [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000970 ! unswitched memory B cell [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002111 ! CD38-negative unswitched memory B cell [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002111 ! CD38-negative unswitched memory B cell [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000970 ! unswitched memory B cell [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002114 ! CD38-positive unswitched memory B cell [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002114 ! CD38-positive unswitched memory B cell [Term] id: CL:0002117 name: IgG-negative class switched memory B cell def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 ! IgG-negative class switched memory B cell [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 ! IgG-negative class switched memory B cell [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell created_by: tmeehan creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL17 secretion." [GOC:dsd, GOC:tfm, PMID:19270712] is_a: CL:0000800 ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell created_by: tmeehan creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [GOC:tfm, PMID:19270712] is_a: CL:0000799 ! immature gamma-delta T cell is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [GOC:tfm, PMID:20581831] is_a: CL:0000911 ! effector T cell created_by: tmeehan creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell def: "A CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg." [GOC:dsd, GOC:tfm, PMID:19201830] comment: Found in the CD27-positive CD28-positive or CD27-negative CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative. synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell [Term] id: CL:0002129 name: regular atrial cardiac myocyte def: "Regular cardiac myocyte of a cardiac atrium." [GOC:tfm] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] xref: FMA:83108 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:03Z [Term] id: CL:0002130 name: regular interatrial cardiac myocyte def: "A cardiac myocyte of the interatrial region of the heart." [GOC:tfm] xref: FMA:228790 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:09Z [Term] id: CL:0002131 name: regular ventricular cardiac myocyte def: "Regular cardiac myocyte of a cardiac ventricle." [GOC:tfm] synonym: "Regular cardiac muscle cell of ventricle" EXACT [] synonym: "Regular ventricular cardiac muscle fiber" EXACT [] synonym: "Ventricular myocyte" EXACT [] xref: FMA:83109 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:13Z [Term] id: CL:0002132 name: stromal cell of ovary def: "A stomal cell of the ovary" [GOC:tfm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell created_by: tmeehan creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002133 name: stromal cell of ovorain cortex def: "A stromal cell of the ovarian cortex." [GOC:tfm] xref: FMA:256169 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T12:12:15Z [Term] id: CL:0002134 name: stromal cell of ovarian medulla def: "A stromal cell of the ovarian medulla." [GOC:tfm] xref: FMA:256171 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T12:12:17Z [Term] id: CL:0002135 name: nonkeratinized cell of epidermis def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [GO:tfm, PMID:1987287] xref: FMA:62880 is_a: CL:0000362 ! epidermal cell created_by: tmeehan creation_date: 2010-08-24T08:43:27Z [Term] id: CL:0002136 name: type II cell of adrenal cortex def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651] synonym: "type II cortical cell of adrenal gland" EXACT [] xref: FMA:69547 is_a: CL:0000460 ! glucocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:42Z [Term] id: CL:0002137 name: type III cell of adrenal cortex def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651] xref: FMA:69564 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:44Z [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148] xref: FMA:68458 is_a: CL:0002139 ! endothelial cell of vascular tree created_by: tmeehan creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002139 name: endothelial cell of vascular tree def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:tfm] synonym: "cubodial endothelial cell of vascular tree" EXACT [] synonym: "vascular endothelial cell" EXACT [] xref: FMA:67755 is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002140 name: acinar cell of sebaceous gland def: "An acinar cell of the sebaceous gland." [GOC:tfm] xref: FMA:70953 is_a: CL:0000622 ! acinar cell created_by: tmeehan creation_date: 2010-08-24T09:27:52Z [Term] id: CL:0002141 name: active chief cell of parathyroid gland def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [FMA:0517223651, GOC:tfm] xref: FMA:69082 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T09:30:15Z [Term] id: CL:0002142 name: dark cell of eccrine sweat gland def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [ISBN:0517223651] xref: FMA:70659 is_a: CL:0000318 ! sweat secreting cell created_by: tmeehan creation_date: 2010-08-24T02:15:16Z [Term] id: CL:0002143 name: dark chief cell of parathyroid cell def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69080 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T02:18:36Z [Term] id: CL:0002144 name: capillary endothelial cell def: "An endothelial cell found in capillaries." [GOC:tfm] xref: FMA:67756 is_a: CL:0000071 ! blood vessel endothelial cell created_by: tmeehan creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell relationship: develops_from CL:0002209 ! intermediate epitheliocyte created_by: tmeehan creation_date: 2010-08-24T03:38:29Z [Term] id: CL:0002146 name: clear cell of eccrine sweat gland def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [GOC:tfm, ISBN:0517223651] xref: FMA:70658 is_a: CL:0000318 ! sweat secreting cell created_by: tmeehan creation_date: 2010-08-24T10:33:02Z [Term] id: CL:0002147 name: clear chief cell of parathyroid cell def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [GOC:tfm, ISBN:0618947256] xref: FMA:69081 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T10:39:42Z [Term] id: CL:0002148 name: dental pulp cell def: "A cell found within the dental pulp." [GOC:tfm, PMID:11087820] xref: FMA:87170 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-24T02:52:09Z [Term] id: CL:0002149 name: epithelial cell of uterus def: "An epithelial cell of the uterus." [GOC:tfm] xref: FMA:256161 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-08-24T10:45:54Z [Term] id: CL:0002150 name: epitheloid cell def: "A nonepithelial cell derived from a macrophage having characteristics resembling those of an epithelial cell, often found in granulomas associated with tuberculosis." [GOC:tfm, ISBN:0618947256] xref: FMA:83514 is_a: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000235 ! macrophage created_by: tmeehan creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002151 name: late promyelocyte def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [FMA:0412046911] xref: FMA:83534 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:50Z [Term] id: CL:0002152 name: columnar cell of endocervix def: "A columnar cell of the cervix uteri." [GOC:tfm, ISBN:0721662544] is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-08-24T10:47:47Z [Term] id: CL:0002153 name: corneocyte def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X] xref: FMA:68650 is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-24T10:53:03Z [Term] id: CL:0002154 name: early promyelocyte def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [FMA:0412046911, GOC:tfm] xref: FMA:83533 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:53Z [Term] id: CL:0002155 name: echinocyte def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [GOC:tfm] synonym: "burr cell" EXACT [] xref: FMA:81099 is_a: CL:0000595 ! enucleate erythrocyte created_by: tmeehan creation_date: 2010-08-24T03:15:21Z [Term] id: CL:0002157 name: endosteal cell def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [FMA:0618947256, GOC:tfm] xref: FMA:86495 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-24T03:33:58Z [Term] id: CL:0002158 name: external epithelial cell of tympanic membrane def: "Epithelial cell found on the external side of the tympanic membrane" [GOC:tfm, PMID:5686391] xref: FMA:70558 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-25T10:25:31Z [Term] id: CL:0002159 name: general ecto-epithelial cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002160 name: basal external epithelial cell of tympanic membrane def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:44Z [Term] id: CL:0002161 name: superficial external epithelial cell of tympanic membrane def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:48Z [Term] id: CL:0002162 name: internal epithelial cell of tympanic membrane def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [FMA:5686391, GOC:tfm] xref: FMA:70626 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-08-25T10:49:46Z [Term] id: CL:0002163 name: internal pillar cell of cochlea def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75722 is_a: CL:1000191 ! pillar cell of cochlea created_by: tmeehan creation_date: 2010-08-25T11:05:21Z [Term] id: CL:0002164 name: external pillar cell of cochlea def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75727 is_a: CL:1000191 ! pillar cell of cochlea created_by: tmeehan creation_date: 2010-08-25T11:05:23Z [Term] id: CL:0002165 name: phalangeal cell of cochlea def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256] xref: FMA:79800 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T01:29:07Z [Term] id: CL:0002166 name: epithelial cell of malassez def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521] synonym: "epithelial cell rests of Malassez " EXACT [] synonym: "epithelial debris of Malassez" EXACT [] xref: FMA:62987 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T08:51:27Z [Term] id: CL:0002167 name: olfactory epithelial cell def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026] xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T01:47:13Z [Term] id: CL:0002168 name: border cell of cochlea def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [FMA:0412046911, GOC:tfm] xref: FMA:79798 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T01:47:12Z [Term] id: CL:0002169 name: basal cell of olfactory epithelium def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026] xref: FMA:62303 is_a: CL:0002167 ! olfactory epithelial cell created_by: tmeehan creation_date: 2010-08-26T01:58:54Z [Term] id: CL:0002170 name: keratinized cell of the oral mucosa def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID: 12014572] is_a: CL:0000312 ! keratinocyte is_a: CL:0002336 ! buccal mucosa cell created_by: tmeehan creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753] synonym: "Blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea def: "A supporting cell that secretes components of the tectorial membrane." [GOC:tfm, PMID:2111803] xref: FMA:79797 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis cells, ISBN:0412046911] synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] synonym: "polar cushion cells" EXACT [] xref: FMA:84143 is_a: CL:0000650 ! mesangial cell is_a: CL:0002320 ! connective tissue cell created_by: tmeehan creation_date: 2010-08-25T02:20:55Z [Term] id: CL:0002174 name: follicular cell of ovary def: "A cell within the follicle of an ovary." [GOC:tfm] xref: FMA:70589 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-25T03:01:27Z [Term] id: CL:0002175 name: primary follicular cell of ovary def: "A cell within the primary follicle of the ovary." [GOC:tfm] xref: FMA:70590 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:42Z [Term] id: CL:0002176 name: secondary follicular cell of ovary def: "A cell of a secondary follicile within the ovary." [GOC:tfm] xref: FMA:70591 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:48Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] synonym: "Folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002178 name: epithelial cell of stomach def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] xref: FMA:62948 is_a: CL:0002251 ! epithelial cell of alimentary canal created_by: tmeehan creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002179 name: foveolar cell of stomach def: "An epithelial cell within the small pits that line the entire stomach. Area of gland development." [GOC:tfm, http://www.merriam-webster.com/medical/foveolar] xref: FMA:86552 is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:23:22Z [Term] id: CL:0002180 name: mucous cell of stomach def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] xref: FMA:63464 is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002181 name: mucus neck cell of gastric gland def: "A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach." [GOC:tfm, ISBN:0517223651] xref: FMA:62954 is_a: CL:0000651 ! neck cell is_a: CL:0002180 ! mucous cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:41:30Z [Term] id: CL:0002182 name: surface mucosal cell of stomach def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651] xref: FMA:62949 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002180 ! mucous cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:45:10Z [Term] id: CL:0002183 name: stem cell of gastric gland def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] xref: FMA:62953 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623] synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:22Z [Term] id: CL:0002185 name: keratinized cell of epidermis def: "A keratinocyte located in the epidermis." [GOC:tfm] xref: FMA:62879 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T02:51:55Z [Term] id: CL:0002186 name: prickle cell of epidermis def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer) of the epidermis. A function of this cell is to generate keratin." [GOC:tfm, ISBN:0721662544, ISBN:0815332181] xref: FMA:69059 is_a: CL:0000649 ! prickle cell is_a: CL:0002185 ! keratinized cell of epidermis created_by: tmeehan creation_date: 2010-08-26T03:10:44Z [Term] id: CL:0002187 name: basal cell of epidermis def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [GOC:tfm, ISBN:0517223651] xref: FMA:70571 is_a: CL:0000646 ! basal cell is_a: CL:0002185 ! keratinized cell of epidermis created_by: tmeehan creation_date: 2010-08-26T03:12:49Z [Term] id: CL:0002188 name: glomerular endothelial cell def: "An endothelial cell found in the glomerulus of the kidney. This cell is\nflattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009] xref: FMA:70970 is_a: CL:0000115 ! endothelial cell is_a: CL:0000666 ! fenestrated cell created_by: tmeehan creation_date: 2010-08-26T10:59:44Z [Term] id: CL:0002189 name: granular cell of epidermis def: "A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules." [ISBN:1416031855] xref: FMA:70543 is_a: CL:0002185 ! keratinized cell of epidermis created_by: tmeehan creation_date: 2010-08-26T03:19:00Z [Term] id: CL:0002190 name: squamous cell of epidermis def: "A flat keratinocyte immediately below the cornified layer." [GOC:tfm, ISBN:0517223651] xref: FMA:86925 is_a: CL:0002185 ! keratinized cell of epidermis created_by: tmeehan creation_date: 2010-08-26T03:37:02Z [Term] id: CL:0002191 name: granulocytopoietic cell def: "A cell involved in the formation of a granulocyte." [GOC:tfm] xref: FMA:83519 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell created_by: tmeehan creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002192 name: metamyelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [GOC:tfm, ISBN:0721601464] xref: FMA:83541 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0002193 ! myelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:15Z [Term] id: CL:0002193 name: myelocyte def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [GOC:tfm, ISBN:0323052908] xref: FMA:83525 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:19Z [Term] id: CL:0002194 name: monopoietic cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] xref: FMA:83552 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell created_by: tmeehan creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002195 name: hepatic stem cell def: "A stem cell that can give rise to the cells of the liver." [GOC:tfm] xref: FMA:86577 is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratiothat can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue" [PMID:17901986] xref: FMA:86576 is_a: CL:0002195 ! hepatic stem cell created_by: tmeehan creation_date: 2010-08-30T02:01:49Z [Term] id: CL:0002197 name: inactive chief cell of parathyoid gland def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [GOC:tfm, ISBN:0517223651] is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:14:01Z [Term] id: CL:0002198 name: oncocyte def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317] synonym: "oxyphil" EXACT [] xref: FMA:67606 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T11:26:49Z [Term] id: CL:0002199 name: oxyphil cell of parathyroid gland def: "An oncocyte located in the parathyroid gland." [PMID:20013317] xref: FMA:69084 is_a: CL:0002198 ! oncocyte is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:23Z [Term] id: CL:0002200 name: oxyphil cell of thyroid def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317] synonym: "Askanazy cells" EXACT [] synonym: "Hurthle cells" EXACT [] xref: FMA:87169 is_a: CL:0002198 ! oncocyte is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:26Z [Term] id: CL:0002201 name: renal beta-intercalated cell def: "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." [GOC:tfm, PMID:11781354] is_a: CL:0005010 ! renal intercalated cell created_by: tmeehan creation_date: 2010-09-02T01:43:55Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] xref: FMA:66816 is_a: CL:0002368 ! respiratory epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002203 name: Brush cell of epithelium proper of large intestine def: "Brush cell found in the epithelial layer of the colon." [GOC:tfm] xref: FMA:263222 is_a: CL:0002204 ! brush cell created_by: tmeehan creation_date: 2010-09-02T02:20:50Z [Term] id: CL:0002204 name: brush cell def: "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "caveolated cell" EXACT [] synonym: "fibrillovesicular cell" EXACT [] synonym: "multivesicular cell" EXACT [] synonym: "tuft cell" EXACT [] xref: FMA:67978 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:28:53Z [Term] id: CL:0002205 name: brush cell of lobular bronchiole def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm] xref: FMA:263220 is_a: CL:0002075 ! brush cell of trachebronchial tree created_by: tmeehan creation_date: 2010-09-02T02:38:34Z [Term] id: CL:0002206 name: brush cell of terminal bronchiole def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm] xref: FMA:263228 is_a: CL:0002075 ! brush cell of trachebronchial tree created_by: tmeehan creation_date: 2010-09-02T02:38:36Z [Term] id: CL:0002207 name: brush cell of trachea def: "Brush cell of the epithelium in the trachea." [GOC:tfm] xref: FMA:263224 is_a: CL:0002075 ! brush cell of trachebronchial tree created_by: tmeehan creation_date: 2010-09-02T02:38:37Z [Term] id: CL:0002208 name: brush cell of bronchus def: "A brush cell found in the epithelium of bronchus." [GOC:tfm] xref: FMA:263226 is_a: CL:0002075 ! brush cell of trachebronchial tree is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:38:42Z [Term] id: CL:0002209 name: intermediate epitheliocyte def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002210 name: red muscle cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651] synonym: "Oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] xref: FMA:84448 is_a: CL:0000188 ! skeletal muscle cell created_by: tmeehan creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: FMA:84413 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell created_by: tmeehan creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm] synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] synonym: "type II muscle fiber" EXACT [] xref: FMA:84414 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651] xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell def: "A type II muscle cell that contain large amounts of myoglobin, have many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm] synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] synonym: "type 2a muscle cell" EXACT [] synonym: "type 2a muscle fiber" EXACT [] synonym: "type IIa muscle fiber" EXACT [] xref: FMA:84415 is_a: CL:0002210 ! red muscle cell is_a: CL:0002212 ! type II muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651] synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] synonym: "type IIb muscle fiber" EXACT [] xref: FMA:84416 is_a: CL:0002212 ! type II muscle cell is_a: CL:0002213 ! white muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002216 name: intermediate muscle cell def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [GOC:tfm] xref: FMA:84450 is_a: CL:0000188 ! skeletal muscle cell created_by: tmeehan creation_date: 2010-09-02T03:51:17Z [Term] id: CL:0002217 name: intermediate trophoblast def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] xref: FMA:86564 is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:04:36Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002219 name: anchoring trophoblasts def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:14:28Z [Term] id: CL:0002220 name: interstitial cell of pineal gland def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002221 name: keratinized squamous cell of esophagus def: "A squamous cell that has keratin in the esophagus." [GOC:tfm, PMID:11694559] xref: FMA:86549 is_a: CL:0000312 ! keratinocyte is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2010-09-07T10:11:06Z [Term] id: CL:0002222 name: vertebrate lens cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] xref: FMA:70950 is_a: CL:0000306 ! crystallin accumulating cell created_by: tmeehan creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)" [GOC:tfm, ISBN:0517223651] xref: FMA:63181 is_a: CL:0002222 ! vertebrate lens cell created_by: tmeehan creation_date: 2010-09-07T10:45:45Z [Term] id: CL:0002224 name: lens epithelial cell def: "A cell of the cuboidal epithelium that covers the lens." [GOC:tfm, ISBN:0721662544] xref: FMA:67559 is_a: CL:0002222 ! vertebrate lens cell created_by: tmeehan creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber def: "A lens fiber that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651] synonym: "secondary lens fibre" EXACT [] is_a: CL:0002222 ! vertebrate lens cell relationship: develops_from CL:0002228 ! primary lens fiber created_by: tmeehan creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002226 name: non-nucleated secondary lens fiber def: "A secondary lens fiber cell that lacks a nucleus." [GOC:tfm] synonym: "non-nucleated secondary lens fibre" EXACT [] xref: FMA:67561 is_a: CL:0002225 ! secondary lens fiber relationship: develops_from CL:0002227 ! nucleated secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:23Z [Term] id: CL:0002227 name: nucleated secondary lens fiber def: "A secondary fiber cell that contains a nucleus." [GOC:tfm] synonym: "nucleated secondary lens fibre" EXACT [] xref: FMA:70949 is_a: CL:0002225 ! secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:26Z [Term] id: CL:0002228 name: primary lens fiber def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704] synonym: "primary lens fibre" EXACT [] xref: FMA:70613 is_a: CL:0002222 ! vertebrate lens cell relationship: develops_from CL:0002223 ! anterior lens cell created_by: tmeehan creation_date: 2010-09-07T11:19:01Z [Term] id: CL:0002229 name: light chief cell of parathyroid gland def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69079 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-07T11:46:54Z [Term] id: CL:0002230 name: epithelial cell of lactiferous gland def: "An epithelial cell of the milk producing gland of mammals." [GOC:tfm] xref: FMA:79866 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-07T01:23:38Z [Term] id: CL:0002231 name: epithelial cell of prostate def: "An epithelial cell of the prostate." [GOC:tfm] synonym: "prostate epithelial cell" EXACT [] xref: FMA:256163 xref: FMA:66817 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-07T01:49:29Z [Term] id: CL:0002232 name: epithelial cell of prostatic duct def: "An epithelial cell of prostatic duct." [GOC:tfm] xref: FMA:74224 is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-07T01:55:51Z [Term] id: CL:0002233 name: epithelial cell of prostatic acinus def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349] xref: FMA:74223 is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-07T01:55:53Z [Term] id: CL:0002234 name: basal cell of prostatic acinus def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm] xref: FMA:74265 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:08Z [Term] id: CL:0002235 name: luminal cell of prostatic acinus def: "A cell of the luminal layer of the epithelium in theprostatic acinus." [GOC:tfm] xref: FMA:74266 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002340 ! luminal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:10Z [Term] id: CL:0002236 name: basal epithelial cell of prostatic duct def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377] xref: FMA:74226 is_a: CL:0002232 ! epithelial cell of prostatic duct is_a: CL:0002341 ! basal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:12Z [Term] id: CL:0002237 name: luminal epithelial cell of prostatic duct def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [GOC:tfm] xref: FMA:74225 is_a: CL:0002232 ! epithelial cell of prostatic duct is_a: CL:0002340 ! luminal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:16Z [Term] id: CL:0002238 name: male gonocyte def: "A primordial germ cell that is destined to become a male germ cell." [GOC:tfm] synonym: "male primordial germ cell" EXACT [] xref: FMA:84771 is_a: CL:0000670 ! primordial germ cell created_by: tmeehan creation_date: 2010-09-07T02:11:13Z [Term] id: CL:0002239 name: ooblast def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [GOC:tfm] synonym: "Ovigerm" EXACT [] xref: ISBN:0721662544 is_a: CL:0000670 ! primordial germ cell created_by: tmeehan creation_date: 2010-09-07T02:11:16Z [Term] id: CL:0002240 name: marrow fibroblast def: "A fibroblast in the bone marrow." [GOC:tfm] xref: FMA:84377 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002241 name: pulmonary interstitial fibroblast def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] synonym: "pulmonary myofibroblast" EXACT [] synonym: "Pulmonary septal cell" EXACT [] xref: FMA:84467 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-07T02:29:38Z [Term] id: CL:0002242 name: nucleate cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000224 ! cell by nuclear number created_by: tmeehan creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000192 ! smooth muscle cell relationship: develops_from CL:0000133 ! neurectodermal cell created_by: tmeehan creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002244 name: squamous cell of ectocervix def: "A nonstratified squamous cell located in the ectocervix." [GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm] synonym: "Ectocervical squamous cell" EXACT [] xref: FMA:86483 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-09-08T09:12:23Z [Term] id: CL:0002245 name: null lymphocyte def: "A lymphocyte that lacks T or B cell surface markers." [GOC:tfm, ISBN:068340007X] xref: FMA:83601 is_obsolete: true created_by: tmeehan creation_date: 2010-09-07T03:43:42Z [Term] id: CL:0002246 name: peripheral blood stem cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] synonym: "PBSC" EXACT [] xref: FMA:86711 is_a: CL:0000037 ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell created_by: tmeehan creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002247 name: pleural macrophage def: "A tissue macrophage that is in the pleural space." [GOC:tfm] xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002248 name: pluripotent stem cell def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID: 19343304] xref: FMA:70570 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-07T04:26:06Z [Term] id: CL:0002249 name: primitive cardiac myocyte def: "A stem cell that can differentiate into a cardiac myocyte." [GOC:tfm, PMID:16938308] xref: FMA:75620 is_a: CL:0000723 ! somatic stem cell is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-07T04:40:32Z [Term] id: CL:0002250 name: intestinal crypt stem cell def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiatess into columnar or goblet cells." [GOC:tfm, ISBN:0517223651] synonym: "stem cell of intestinal crypt of lieberkuhn" EXACT [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] synonym: "epithelial cell of gut" EXACT [] xref: FMA:72289 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus def: "An epithelial cell of the esophagus." [GOC:tfm] xref: FMA:63071 is_a: CL:0002251 ! epithelial cell of alimentary canal created_by: tmeehan creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine def: "An epithelial cell of the large intestine." [GOC:tfm] synonym: "epithelial cell of colon" RELATED [] xref: FMA:256157 is_a: CL:0002251 ! epithelial cell of alimentary canal created_by: tmeehan creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine def: "An epithelial cell of the small intestine." [GOC:tfm] xref: FMA:256159 is_a: CL:0002251 ! epithelial cell of alimentary canal created_by: tmeehan creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002255 name: stromal cell of endometrium def: "An epithelial cell that regulates growth and differentiation of the overlying epithelium." [GOC:tfm, PMID:11331626] xref: FMA:86490 is_a: CL:0000499 ! stromal cell is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-09-08T09:50:04Z [Term] id: CL:0002256 name: supporting cell of carotid body def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus cells, PMID:8985136] synonym: "carotid body sustentacular cell" EXACT [] synonym: "type 2 carotid body cells" EXACT [] synonym: "type II carotid body cell" EXACT [] xref: FMA:84188 is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-08T10:34:45Z [Term] id: CL:0002257 name: epithelial cell of thyroid gland def: "An epithelial cell of thyroid gland." [GOC:tfm] xref: FMA:256167 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-08T01:46:51Z [Term] id: CL:0002258 name: thyroid follicular cell def: "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." [GOC:tfm, ISBN:0517223651] synonym: "Follicular cell of thyroid gland" EXACT [] synonym: "principal cell of thyroid gland" EXACT [] synonym: "thyroid gland follicular cell" EXACT [] xref: FMA:68782 is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:50:08Z [Term] id: CL:0002259 name: neuroepithelial stem cell def: "The stem cell from which glial precursor cell arises from." [GOC:tfm, PMID:11687496] synonym: "totipotent neuroepithelial stem cell" NARROW [] xref: FMA:87171 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-08T02:14:14Z [Term] id: CL:0002260 name: epithelial cell of parathyroid gland def: "An epithelial cell of the parathyroid gland." [GOC:tfm] xref: FMA:70547 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-08T02:29:38Z [Term] id: CL:0002261 name: endothelial cell of viscerocranial mucosa def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256] xref: FMA:70627 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-14T10:40:12Z [Term] id: CL:0002262 name: endothelial cell of sinusoid def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] xref: FMA:63134 is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002263 name: transitional cell of parathyroid gland def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [GOC:tfm, ISBN:0412046911] xref: FMA:69324 is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:33:50Z [Term] id: CL:0002264 name: type A cell of stomach def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] xref: FMA:83411 is_a: CL:0002067 ! type A enterocrine cell created_by: tmeehan creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon def: "A D cell located in the colon." [GOC:tfm] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine def: "A type D cell of the small intestine." [GOC:tfm] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach def: "A type D cell found in the stomach." [GOC:tfm] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002268 name: P/D1 enteroendocrine cell def: "An enteroendocrine cell that stores and secretes Ghrelin." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63207 xref: FMA:63418 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell created_by: tmeehan creation_date: 2010-09-10T01:47:45Z [Term] id: CL:0002269 name: vasoactive intestinal peptide secreting cell def: "An endocrine cell that secretes vasoactive intestinal peptide." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T01:52:20Z [Term] id: CL:0002270 name: type EC2 enteroendocrine cell def: "A type EC enteroendocrine cellin the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] synonym: "M endocrine cell" EXACT [] synonym: "M enteroendocrine cell" EXACT [] synonym: "Mo enteroendocrine cell" EXACT [] xref: FMA:62941 xref: FMA:63420 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell created_by: tmeehan creation_date: 2010-09-10T02:13:47Z [Term] id: CL:0002271 name: type EC1 enteroendocrine cell def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651] xref: FMA:62940 is_a: CL:0000505 ! substance P secreting cell is_a: CL:0000577 ! type EC enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T02:13:49Z [Term] id: CL:0002272 name: motilin secreting cell def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [GOC:tfm, MESH:D06.472.317.525] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T02:31:13Z [Term] id: CL:0002273 name: type ECL enteroendocrine cell def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63208 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell created_by: tmeehan creation_date: 2010-09-10T02:35:17Z [Term] id: CL:0002274 name: histamine secreting cell def: "A cell type that secretes histamine." [GOC:tfm] is_a: CL:0000457 ! biogenic amine secreting cell created_by: tmeehan creation_date: 2010-09-10T03:04:42Z [Term] id: CL:0002275 name: PP cell of pancreatic islet def: "A PP cell located in the pancreatic acinus." [GOC:tfm] synonym: "Pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: FMA:70588 is_a: CL:0000696 ! PP cell created_by: tmeehan creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002276 name: PP cell of pancreatic acinus def: "A PP cell located in the pancreatic acinus." [GOC:tfm] synonym: "Type F cell of pancreatic acinus" EXACT [] xref: FMA:85400 is_a: CL:0000696 ! PP cell created_by: tmeehan creation_date: 2010-09-10T03:30:33Z [Term] id: CL:0002277 name: type I enteroendocrine cell def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [GOC:tfm] synonym: "CCK cell" EXACT [] xref: FMA:62937 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:44:36Z [Term] id: CL:0002278 name: GIP cell def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [GOC:tfm] synonym: "Type K enteroendocrine cell" EXACT [] xref: FMA:62942 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:51:47Z [Term] id: CL:0002279 name: type L enteroendocrine cell def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-\nlike immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [ISBN:0517223651, PMID:15153415] xref: FMA:62944 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:59:09Z [Term] id: CL:0002280 name: type N enteroendocrine cell def: "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." [GOC:tfm] synonym: "N cell" EXACT [] xref: FMA:62943 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T04:08:29Z [Term] id: CL:0002281 name: type S enteroendocrine cell def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [GOC:tfm, PMID:15153415] xref: FMA:62936 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000458 ! serotonin secreting cell created_by: tmeehan creation_date: 2010-09-10T04:44:46Z [Term] id: CL:0002282 name: type TG enteroendocrine cell def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [DOI:10.1007/978-3-211-99390-3, GOC:tfm, PMID:7013499] xref: FMA:63421 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000509 ! gastrin secreting cell created_by: tmeehan creation_date: 2010-09-13T09:48:34Z [Term] id: CL:0002283 name: ecto-epithelial cell of viscerocranial mucosa def: "An epithelial cell of the mucosa associated with facial skeleton." [GOC:tfm, ISBN:0323052908] xref: FMA:70581 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:04:02Z [Term] id: CL:0002284 name: type X enteroendocrine cell def: "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." [GOC:tfm, PMID:20616512] synonym: "A-like" EXACT [] synonym: "X/A-like" EXACT [] xref: FMA: 63209 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0005018 ! ghrelin secreting cell created_by: tmeehan creation_date: 2010-09-13T10:12:12Z [Term] id: CL:0002285 name: type III taste bud cell def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [GOC:tfm, ISBN:0517223651, PMID:15738192] synonym: "taste bud basal cell" BROAD [] synonym: "type 3 taste cell" EXACT [] xref: FMA:67940 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:21Z [Term] id: CL:0002286 name: type II taste cell def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [GOC:tfm, PMID:15738192] synonym: "type 2 taste cell" EXACT [] synonym: "type II taste cell" EXACT [] xref: FMA:62381 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:26Z [Term] id: CL:0002287 name: type IV taste receptor cell def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [GOC:tfm, ISBN:0517223651, PMID:15738192] comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID: 15738192. synonym: "taste bud basal cell" BROAD [] synonym: "type 4 taste cell" EXACT [] xref: FMA:62380 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:29Z [Term] id: CL:0002288 name: type V taste receptor cell def: "A cell type that forms the boundary with the surrounding epithelium." [GOC:tfm, ISBN:0517223651] xref: FMA:67941 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:31Z [Term] id: CL:0002289 name: type I taste bud cell def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:15738192] synonym: "dark tongue cell" EXACT [] synonym: "type I taste cell" EXACT [] synonym: "type taste 1 cell" EXACT [] xref: FMA:62356 is_a: CL:0000209 ! taste receptor cell is_a: CL:0000703 ! sustentacular cell created_by: tmeehan creation_date: 2010-09-13T10:57:35Z [Term] id: CL:0002290 name: Y chromosome-bearing sperm cell def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "Y bearing sperm" EXACT [] synonym: "Y-bearing sperm" EXACT [] xref: FMA:84058 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:24Z [Term] id: CL:0002291 name: X chromosome-bearing sperm cell def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "X bearing sperm" EXACT [] synonym: "X-bearing sperm" EXACT [] xref: FMA:84057 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:26Z [Term] id: CL:0002292 name: type I cell of carotid body def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651] synonym: "glomus cell" EXACT [] synonym: "type I cell of carotid body" EXACT [] xref: FMA:84186 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-13T01:40:21Z [Term] id: CL:0002293 name: epithelial cell of thymus def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "Epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "Thymic epithelial cell" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: FMA:72208 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335] synonym: "subcapsular thymic epithelial cell" EXACT [] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus def: "A thymic epithelial cell that has an eccentric,\nround or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [GOC:tfm, PMID:19721455, PMID:9264335] synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [FMA:0412046911, GOC:tfm, PMID:9264335] synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [PMID:9264335] synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [GOC:tfm, ISBN:0412046911, PMID:19721455, PMID:9264335] synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [GOC:tfm, ISBN:0412046911, PMID:9264335] synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [GOC:tfm, PMID:19721455] synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002301 name: type B synovial cell def: "A synovial cell type that resembles fibroblasts,has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." [GOC:tfm, ISBN:0517223651] xref: FMA:66788 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:14Z [Term] id: CL:0002302 name: type A synovial cell def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [GOC:tfm, ISBN:0517223651] synonym: "type A synoviocyte" EXACT [] xref: FMA:66787 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:17Z [Term] id: CL:0002303 name: pigmented ciliary epithelial cell def: "A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells." [PMID:15106942] synonym: "PE" EXACT [] xref: FMA:70606 is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:27Z [Term] id: CL:0002304 name: non-pigmented ciliary epithelial cell def: "A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells." [GOC:tfm, PMID:15106942] synonym: "NPE" EXACT [] xref: FMA: 70607 is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:31Z [Term] id: CL:0002305 name: epithelial cell of distal tubule def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651] xref: FMA:62125 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:12:12Z [Term] id: CL:0002306 name: epithelial cell of proximal tublule def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3] xref: FMA:62125 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:23:40Z [Term] id: CL:0002307 name: brush border cell of the proximal tubule def: "A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow." [GOC:tfm, ISBN:1-4160-2328-3] is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002306 ! epithelial cell of proximal tublule created_by: tmeehan creation_date: 2010-09-14T11:29:20Z [Term] id: CL:0002308 name: epithelial cell of skin gland def: "An epithelial cell of a skin gland." [GOC:tfm] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002309 name: corticotroph def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [GOC:tfm, ISBN:0517223651] xref: FMA:83098 is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:08:23Z [Term] id: CL:0002310 name: mammosomatotroph def: "An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone." [GOC:tfm] xref: FMA:83097 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:25:34Z [Term] id: CL:0002311 name: mammotroph def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl] synonym: "epsilon-acidophil" EXACT [] synonym: "lactotrope" EXACT [] synonym: "lactotroph" EXACT [] synonym: "lactotropic cell" EXACT [] synonym: "mammotrope" EXACT [] synonym: "mammotrophic cell" EXACT [] synonym: "mammotropic cell" EXACT [] xref: FMA:83096 is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:30:57Z [Term] id: CL:0002312 name: somatotroph def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrope" EXACT [] synonym: "somatotroph" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm] synonym: "Neuro-epithelial cell of prostate gland" EXACT [] xref: FMA: 74390 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T03:01:58Z [Term] id: CL:0002314 name: external supporting cell of vestibular epithelium def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as\nvimentin, S100, glutamate-aspartate transporter, low affinity\nneurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [GOC:tfm, PMID:20837532] xref: FMA:75809 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:20:01Z [Term] id: CL:0002315 name: supporting cell of cochlea def: "An epithelial supporting cell located in the cochlea." [GOC:tfm] xref: FMA:79796 is_a: CL:0005014 ! auditory epithelial support cell created_by: tmeehan creation_date: 2010-09-14T03:31:38Z [Term] id: CL:0002316 name: supporting cell of vestibular epithelium def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532] xref: FMA:75607 is_a: CL:0005014 ! auditory epithelial support cell created_by: tmeehan creation_date: 2010-09-14T03:31:44Z [Term] id: CL:0002317 name: external limiting cell of vestibular epithelium def: "An external limiting cell found in the vestibular epithelium." [GOC:tfm] xref: FMA:75808 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:33:50Z [Term] id: CL:0002318 name: periperhal blood mesothelial cell def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528] xref: FMA:86712 is_a: CL:0000081 ! blood cell relationship: develops_from CL:0000077 ! mesothelial cell created_by: tmeehan creation_date: 2010-09-15T10:47:11Z [Term] id: CL:0002319 name: neural cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] xref: FMA:70333 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell created_by: tmeehan creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] xref: FMA:63875 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell created_by: tmeehan creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell def: "A cell of the embryo." [FMA:0618947256] xref: FMA:82841 is_a: CL:0000548 ! animal cell created_by: tmeehan creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002322 name: embryonic stem cell def: "A stem cell of embryonic origin." [GOC:tfm, ISBN:068340007X] xref: FMA:82841 is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell created_by: tmeehan creation_date: 2010-09-15T03:44:35Z [Term] id: CL:0002323 name: amniocyte def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the\nfetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847] is_a: CL:0000349 ! extraembryonic cell created_by: tmeehan creation_date: 2010-09-20T10:13:37Z [Term] id: CL:0002324 name: myoepithelial cell of mammary gland def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [GOC:tfm, PMID:11250738, PMID:19022771] is_a: CL:0000185 ! myoepithelial cell is_a: CL:0002327 ! mammary epithelial cell created_by: tmeehan creation_date: 2010-09-20T11:42:14Z [Term] id: CL:0002325 name: mammary alveolar cell def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000314 ! milk secreting cell is_a: CL:0002327 ! mammary epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:30:57Z [Term] id: CL:0002326 name: luiminal epithelial cell of mammary gland def: "A cuboidal epithelial cell that lines the ducts of mammary glands. This cell type expresses keratin-18 and is estrogen-receptor alpha positive." [GOC:tfm, PMID:19022771] synonym: "mammary ductal luminal epithelial cell" EXACT [] is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:37:53Z [Term] id: CL:0002327 name: mammary epithelial cell def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771] synonym: "breast epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:49:37Z [Term] id: CL:0002328 name: bronchial epithelial cell def: "An epithelial cell of the bronchus." [GOC:tfm] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:10:36Z [Term] id: CL:0002330 name: undifferentiated cell of bronchus epithelium def: "An undifferentiated columnar cell of the bronchus epithelium" [goc:tfm, PMID:18757316] is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-20T02:17:58Z [Term] id: CL:0002331 name: basal cell of bronchus def: "A basal cell found in the bronchus epithelium." [GOC:tfm, PMID:18757316] is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:18:08Z [Term] id: CL:0002332 name: ciliated cell of the bronchus def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-20T02:21:12Z [Term] id: CL:0002333 name: neural crest derived fat cell def: "A fat cell derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! fat cell relationship: develops_from CL:0000005 ! fibroblast neural crest derived created_by: tmeehan creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119] is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2010-09-20T02:38:38Z [Term] id: CL:0002336 name: buccal mucosa cell def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:A10.615.550.599] is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2010-09-20T02:52:54Z [Term] id: CL:0002337 name: keratinocyte stem cell def: "A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair." [PMID:15339667] synonym: "bulge keratinocyte" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-09-20T03:07:03Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 ! immature natural killer cell disjoint_from: CL:0000824 ! mature natural killer cell relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002339 name: prostate stem cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377] synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-20T03:21:06Z [Term] id: CL:0002340 name: luminal cell of prostate epithelium def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [GOC:tfm] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:05Z [Term] id: CL:0002341 name: basal cell of prostate epithelium def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:10Z [Term] id: CL:0002342 name: circulating endothelial cell def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [GOC:tfm, PMID:19652886] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-20T03:49:58Z [Term] id: CL:0002343 name: decidual natural killer cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 ! immature natural killer cell disjoint_from: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422] comment: Markers are associated with mouse cells. synonym: "preNK.BM" BROAD [] is_a: CL:0000823 ! immature natural killer cell relationship: develops_from CL:0002346 ! Dx5-negative, NK1.1-positive immature natural killer cell created_by: tmeehan creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763] is_a: CL:0000823 ! immature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell relationship: develops_from CL:0002349 ! CD27-high, CD11b-low natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell relationship: develops_from CL:0002347 ! CD27-high, CD11b-high natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell relationship: develops_from CL:0002345 ! CD27-low, CD11b-low immature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002350 name: endocardial cell def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] synonym: "endocardial endothelial cell" EXACT [] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas def: "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494] synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell relationship: develops_from CL:0002361 ! primitive erythroid progenitor created_by: tmeehan creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002356 name: primitive reticulocyte def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "megalocyte" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell created_by: tmeehan creation_date: 2010-09-22T09:35:16Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698] synonym: "macrocyte" EXACT [] is_a: CL:0000595 ! enucleate erythrocyte relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor cell created_by: tmeehan creation_date: 2010-09-22T09:38:32Z [Term] id: CL:0002358 name: pyrenocyte def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [GOC:tfm] is_a: CL:0002417 ! primitive erythroid lineage cell created_by: tmeehan creation_date: 2010-09-22T10:02:37Z [Term] id: CL:0002359 name: placental hematopoietic stem cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:30:02Z [Term] id: CL:0002360 name: AGM hematopoietic stem cell def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:31:49Z [Term] id: CL:0002361 name: primitive erythroid progenitor def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell relationship: develops_from CL:0002418 ! hemangioblast created_by: tmeehan creation_date: 2010-09-22T10:47:28Z [Term] id: CL:0002362 name: granule cell precursor def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [GOC:tfm, PMID:14745007] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) created_by: tmeehan creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte def: "A keratocyte is a specialized fibroblast residing in the stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5] synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000057 ! fibroblast relationship: develops_from CL:0000008 ! cranial neural crest cell created_by: tmeehan creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002364 name: cortical thymic epithelial cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190] synonym: "cTEC" EXACT [] is_a: CL:0002293 ! epithelial cell of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458] synonym: "mTEC" EXACT [] is_a: CL:0002293 ! epithelial cell of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002366 name: myometrial cell def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640] synonym: "myometrium smooth muscle cell" EXACT [] is_a: CL:0000192 ! smooth muscle cell created_by: tmeehan creation_date: 2010-09-23T03:46:34Z [Term] id: CL:0002367 name: trabecular meshwork cell def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [GOC:tfm, PMID:14500801] synonym: "trabeculocyte" EXACT [] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-23T04:18:50Z [Term] id: CL:0002368 name: respiratory epithelial cell def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] synonym: "airway epithelial cell" EXACT [] is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002370 name: respiratory goblet cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544] is_a: CL:0000160 ! goblet cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-23T04:42:27Z [Term] id: CL:0002371 name: somatic cell def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544] is_a: CL:0000144 ! cell by function created_by: tmeehan creation_date: 2010-09-24T09:44:42Z [Term] id: CL:0002372 name: myotubule def: "A developing muscle cell or fiber with a centrally-located nucleus that results from fusion of skeletal myoblasts." [GOC:tfm, ISBN:0323052908] is_a: CL:0000515 ! skeletal muscle myoblast created_by: tmeehan creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002373 name: growth hormone releasing hormone secreting cell def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [GOC:dph, GOC:tfm] synonym: "GHRH secreting cell" EXACT [] synonym: "somatocrinin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-24T01:36:44Z [Term] id: CL:0002374 name: inner ear hair cell def: "A hair cell of the inner ear that contains the organs of balance and hearing." [GOC:dph, GOC:qtfm, GOC:tfm, ISBN:0192801023] synonym: "inner ear receptor cell" EXACT [] is_a: CL:0000855 ! hair cell created_by: tmeehan creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm] is_a: CL:0000030 ! glioblast relationship: develops_from CL:0000333 ! neural crest cell created_by: tmeehan creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002376 name: non-myelinating Schwann cell def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [GOC:cvs, GOC:tfm, ISBN:0721662544] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0002377 ! immature Schwann cell created_by: tmeehan creation_date: 2010-09-24T02:10:26Z [Term] id: CL:0002377 name: immature Schwann cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0002375 ! Schwann cell precursor created_by: tmeehan creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002379 name: meningothelial cell def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [GOC:tfm, http://www.aippg.net/forum/viewtopic.php?t=62590] synonym: "arachnoid cap cell" EXACT [] xref: FMA:86588 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-28T02:23:46Z [Term] id: CL:0002380 name: oospore def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [GOC:tfm, ISBN:0851988857, SGD:clt] xref: FAO:0000039 is_a: CL:0000605 ! asexual spore created_by: tmeehan creation_date: 2010-10-01T09:22:45Z [Term] id: CL:0002381 name: uninucleate conidium def: "A conidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000025 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:26:39Z [Term] id: CL:0002382 name: multinucleate conidium def: "A conidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000033 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:31:28Z [Term] id: CL:0002383 name: conidium of conidiophore head def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [GOC:tfm, PMID:9529886, SGD:clt] xref: FAO:0000033 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002384 name: uninucleate macroconidium def: "A macroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000029 is_a: CL:0000606 ! macroconidium is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002385 name: blastoconidium def: "An oblong or round asexual spore formed from conidial chains." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "blastospore" RELATED [] xref: FAO:0000042 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002386 name: multinucleate macroconidium def: "A macroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000035 is_a: CL:0000606 ! macroconidium is_a: CL:0002382 ! multinucleate conidium [Term] id: CL:0002387 name: arthroconidium def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "arthrospore" RELATED [] xref: FAO:0000041 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002388 name: multinucleate arthroconidium def: "An arthroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000037 is_a: CL:0002386 ! multinucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002389 name: uninucleate arthroconidium def: "An arthroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000031 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002390 name: uninucleate blastconidium def: "A blastoconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000030 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002385 ! blastoconidium [Term] id: CL:0002391 name: multinucleate blastoconidium def: "A blastoconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000036 is_a: CL:0002385 ! blastoconidium is_a: CL:0002386 ! multinucleate macroconidium [Term] id: CL:0002392 name: plant spore def: "A plant cell that arises through meiosis and develops into a gametophyte." [GOC:tfm, PO:0025017] xref: PO:0025017 is_a: CL:0000610 ! plant cell created_by: tmeehan creation_date: 2010-10-01T10:54:15Z [Term] id: CL:0002393 name: intermediate monocyte def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168] is_a: CL:0000576 ! monocyte created_by: tmeehan creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell def: "A myeloid dendritic cell found in the blood that is CD141-positive and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [GOC:tfm, PMID:20628149] comment: Markers are found in human cells. is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell created_by: tmeehan creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high monocyte def: "A resident monocyte that is Gr-1 low, CD43-negative and CX3CR1-negative." [GOC:tfm, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-positive. is_a: CL:0000860 ! inflammatory monocyte is_a: CL:0001022 ! CD115-positive monocyte created_by: tmeehan creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte def: "A patrolling monocyte that is CD14-low and CD16-positive." [GOC:tfm, PMID:20870168] comment: Markers are associated with human monocytes. is_a: CL:0000875 ! patrolling monocyte relationship: develops_from CL:0002397 ! CD14-positive, CD16-positive monocyte created_by: tmeehan creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte def: "An intermediate monocyte that is CD14-positive, CD16-positive." [GOC:tfm, PMID:20628149] comment: Markers are associated with human cells. is_a: CL:0002393 ! intermediate monocyte relationship: develops_from CL:0002057 ! CD14-positive, CD16-negative monocyte created_by: tmeehan creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte relationship: develops_from CL:0002395 ! Gr1-high monocyte created_by: tmeehan creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell def: "A myeloid dendritic cell found in the blood that is CD1c-positive, CD19-negative, and CD20-negative." [GOC:tfm, PMID:20628149] is_a: CL:0000782 ! myeloid dendritic cell created_by: tmeehan creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: Fraction B/C precursor B cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000817 ! precursor B cell created_by: tmeehan creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002218 ! immature dendritic epithelial T cell precursor created_by: tmeehan creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000785 ! mature B cell is_a: CL:0000822 ! B-2 B cell created_by: tmeehan creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002378 ! immature Vgamma2-positive fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte def: "A thymocyte found in the fetal thymus." [GOC:tfm] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [GOC:tfm, http://www.immgen.org] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002406 ! immature Vgamma2-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002408 ! immature Vgamma2-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org] synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002417 name: primitive erythroid lineage cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm] is_a: CL:0000764 ! erythroid lineage cell created_by: tmeehan creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698] is_a: CL:0000222 ! mesodermal cell relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell created_by: tmeehan creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 ! T cell created_by: tmeehan creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell def: "A T cell that has not completed T cell selection." [GOC:tfm] synonym: "immature T-cell" EXACT [] is_a: CL:0000084 ! T cell created_by: tmeehan creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002421 name: nucleated reticulocyte def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 ! reticulocyte created_by: tmeehan creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464] xref: FMA:66785 is_a: CL:0000558 ! reticulocyte created_by: tmeehan creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002423 name: DN2a thymocyte def: "A DN2 thymocyte that is Kit-hi." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 ! DN2 thymocyte created_by: tmeehan creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte def: "A DN2 thymocyte that is Kit-low." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 ! DN2 thymocyte relationship: develops_from CL:0002423 ! DN2a thymocyte created_by: tmeehan creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002425 name: early T lineage precursor def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 ! pro-T cell created_by: tmeehan creation_date: 2010-10-21T01:16:24Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [GOC:tfm, http://www.immgen.org/index_content.html] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002427 ! resting double-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002428 ! double-positive blast created_by: tmeehan creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http:www.immgen.org/index_content.html] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell def: "A mature NK cell that is NK1.1-positive." [GOC:tfm] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell def: "A NK1.1-positive T cell that is NKGA2-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell def: "A NK1.1-positive T cell that is Ly49D-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell def: "A NK1.1-positive T cell that is CD94-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell is_a: CL:0002446 ! Ly49CI-negative natural killer cell is_a: CL:0002447 ! CD94-negative natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell def: "A NK1.1-positive T cell that is Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell def: "A NK1.1-positive T cell that is Ly49H-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell def: "A NK1.1-positive T cell that is Ly49D-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell def: "A NK1.1-positive T cell that is Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell def: "A NK1.1-positive T cell that is CD94-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell def: "A NK1.1-positive T cell that is Ly49H-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell is_a: CL:0002441 ! CD94-positive natural killer cell is_a: CL:0002443 ! Ly49CI-positive natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0005000 name: spinal cord interneuron def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0005001 name: iridoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS] comment: Derived from UBERON:0002342 neural crest. is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0005002 name: xanthoblast def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0005003 name: leucoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0005004 name: pigment erythroblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0005005 name: cyanoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! neural crest cell [Term] id: CL:0005006 name: ionocyte def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0005007 name: Kolmer-Agduhr neuron def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739] synonym: "KA cell" EXACT [] synonym: "KA interneuron" EXACT [PMID:15539490] synonym: "KA neuron" EXACT [PMID:9634146] synonym: "Kolmer-Agduhr cell" EXACT [] is_a: CL:0000617 ! GABAergic neuron is_a: CL:0005000 ! spinal cord interneuron [Term] id: CL:0005008 name: macular hair cell def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [GO:cvs] is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0005009 name: renal principal cell def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts." [CL:CVS] is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0005010 name: renal intercalated cell def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS] synonym: "Intercalated cell" EXACT [] xref: FMA:86560 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0005011 name: renal alpha-intercalated cell def: "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." [CL:CVS] is_a: CL:0005010 ! renal intercalated cell [Term] id: CL:0005012 name: multi-ciliated epithelial cell def: "A ciliated epithelial cell with many cilium." [CL:CVS] is_a: CL:0000067 ! ciliated epithelial cell [Term] id: CL:0005013 name: single ciliated epithelial cell def: "A ciliated epithelial cell with a single cilium." [CL:CVS] is_a: CL:0000067 ! ciliated epithelial cell [Term] id: CL:0005014 name: auditory epithelial support cell def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm] is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0005015 name: inner phalangeal cell def: "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." [CL:CVS] xref: FMA:79801 is_a: CL:0002165 ! phalangeal cell of cochlea [Term] id: CL:0005016 name: apical cell def: "The apical cell is the upper cell formed after the first division of a plant zygote." [TAIR:TB] is_a: CL:0000610 ! plant cell [Term] id: CL:0005017 name: plant basal cell def: "The lower cell formed after the first division of a plant zygote." [TAIR:TB] is_a: CL:0000610 ! plant cell [Term] id: CL:0005018 name: ghrelin secreting cell def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0005019 name: pancreatic epsilon cell def: "Ghrelin secreting cells found in the found in the exocrine pancreas." [PMID:14970313] comment: In mammals the endocrine pancreas is call the Islets of Langerhans. is_a: CL:0005018 ! ghrelin secreting cell [Term] id: CL:1000036 name: hepatic oval cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:1000082 name: stretch receptor cell is_a: CL:0000006 ! neuronal receptor cell (sensu Animalia) [Term] id: CL:1000083 name: stratified keratinized epithelial stem cell is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000085 name: stratified non keratinized epithelial stem cell is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000191 name: pillar cell of cochlea def: "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." [GOC:tfm, PMID:12417662] synonym: "cochlear pillar cell" RELATED [] synonym: "pillar cell of cochlea" EXACT [] synonym: "pillar cell of corti" EXACT [] synonym: "Rod cell of Corti" EXACT [] xref: FMA:75722 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:1000274 name: trophectodermal cell synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell [Typedef] id: develops_from name: develops_from