format-version: 1.2 data-version: releases/2014-03-05 subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis" synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens" synonymtypedef: LATIN "latin term" synonymtypedef: PLURAL "plural term" remark: See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo. ontology: cl owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nEquivalentClasses( ObjectSomeValuesFrom( ))\nEquivalentClasses( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) ))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nEquivalentClasses( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) ))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nEquivalentClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nSubClassOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectSomeValuesFrom( ) ObjectComplementOf(ObjectSomeValuesFrom( )))\nSubClassOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\n) [Term] id: CHEBI:23367 name: molecular entity is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:24431 name: chemical entity [Term] id: CHEBI:24651 name: hydroxides is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25179 name: melanin is_a: CHEBI:26195 ! polyphenol [Term] id: CHEBI:25367 name: molecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25806 name: oxygen molecular entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:26195 name: polyphenol is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:33304 name: chalcogen molecular entity is_a: CHEBI:33675 ! p-block molecular entity [Term] id: CHEBI:33579 name: main group molecular entity is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33582 name: carbon group molecular entity is_a: CHEBI:33675 ! p-block molecular entity [Term] id: CHEBI:33595 name: cyclic compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33608 name: hydrogen molecular entity is_a: CHEBI:33674 ! s-block molecular entity [Term] id: CHEBI:33655 name: aromatic compound is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33659 name: organic aromatic compound is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33674 name: s-block molecular entity is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:33675 name: p-block molecular entity is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:33822 name: organic hydroxy compound is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33832 name: organic cyclic compound is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33853 name: phenols is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:36357 name: polyatomic entity is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:37577 name: heteroatomic molecular entity is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:50860 name: organic molecular entity is_a: CHEBI:33582 ! carbon group molecular entity [Term] id: CHEBI:72695 name: organic molecule is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CL:0000000 name: cell namespace: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: GO:0005575 ! cellular_component equivalent_to: GO:0005623 ! cell [Term] id: CL:0000001 name: primary cultured cell namespace: cell def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." [ReO:mhb] comment: Covers cells actively being cultured or stored in a quiescent state for future use. synonym: "primary cell culture cell" EXACT [] synonym: "primary cell line cell" RELATED [] synonym: "unpassaged cultured cell" EXACT [] xref: BTO:0002290 is_a: CL:0000010 ! cultured cell [Term] id: CL:0000002 name: obsolete immortal cell line cell namespace: cell def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "continuous cell line cell" EXACT [] synonym: "permanent cell line cell" EXACT [] is_obsolete: true replaced_by: CLO:0000019 [Term] id: CL:0000003 name: native cell namespace: cell def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah] comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). subset: ubprop:upper_level synonym: "cell in vivo" NARROW [] xref: CARO:0000013 is_a: CL:0000000 ! cell is_a: GO:0005623 ! cell [Term] id: CL:0000004 name: obsolete cell by organism namespace: cell def: "OBSOLETE: A classification of cells by the organisms within which they are contained." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000005 name: fibroblast neural crest derived namespace: cell is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell namespace: cell synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000197 ! receptor cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable_of detection of stimulus involved in sensory perception relationship: RO:0002215 GO:0050906 ! capable_of detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell namespace: cell def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000008 name: migratory cranial neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000009 name: obsolete fusiform initial namespace: cell alt_id: CL:0000274 def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208] comment: replaced_by: PO:0000079 synonym: "xylem initial" RELATED [] synonym: "xylem mother cell" RELATED [] is_obsolete: true [Term] id: CL:0000010 name: cultured cell namespace: cell def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [ReO:mhb] comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000011 name: migratory trunk neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000012 name: obsolete cell by class namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000013 name: obsolete dentine secreting cell namespace: cell is_obsolete: true consider: CL:0000140 [Term] id: CL:0000014 name: germ line stem cell namespace: cell synonym: "germline stem cell" EXACT [] is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0000039 {is_inferred="true"} ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: RO:0002215 GO:0017145 ! capable_of stem cell division relationship: RO:0002215 GO:0017145 ! capable_of stem cell division [Term] id: CL:0000015 name: male germ cell namespace: cell xref: FMA:72290 xref: MA:0002765 xref: ncithesaurus:Spermatogenic_Cell xref: VHOG:0001531 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0007283 ! capable_of spermatogenesis relationship: RO:0002215 GO:0007283 ! capable_of spermatogenesis [Term] id: CL:0000016 name: male germ line stem cell namespace: cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte namespace: cell def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A05.360.490.890.880] xref: BTO:0001275 xref: CALOHA:TS-0951 xref: EMAPA:31484 xref: FBbt:00004936 xref: FMA:84049 xref: WBbt:0006799 is_a: CL:0000015 {is_inferred="true"} ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0002215 GO:0048137 ! capable_of spermatocyte division relationship: develops_from CL:0000020 ! spermatogonium relationship: RO:0002215 GO:0048137 ! capable_of spermatocyte division [Term] id: CL:0000018 name: spermatid namespace: cell def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A05.360.490.890.860] synonym: "nematoblast" EXACT [] xref: BTO:0001274 xref: CALOHA:TS-0950 xref: EMAPA:31486 xref: FBbt:00004942 xref: FMA:72294 xref: WBbt:0006800 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000413 ! haploid cell intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0001675 ! capable_of acrosome assembly intersection_of: RO:0002215 GO:0007288 ! capable_of sperm axoneme assembly intersection_of: RO:0002215 GO:0007289 ! capable_of spermatid nucleus differentiation relationship: bearer_of PATO:0001375 ! haploid relationship: develops_from CL:0000657 ! secondary spermatocyte relationship: RO:0002215 GO:0001675 ! capable_of acrosome assembly relationship: RO:0002215 GO:0007288 ! capable_of sperm axoneme assembly relationship: RO:0002215 GO:0007289 ! capable_of spermatid nucleus differentiation [Term] id: CL:0000019 name: sperm namespace: cell def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A05.360.490.890] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] xref: BTO:0001277 xref: BTO:0002046 xref: CALOHA:TS-0949 xref: FBbt:00004954 xref: FMA:67338 xref: WBbt:0006798 is_a: CL:0000219 ! motile cell is_a: CL:0000408 {is_inferred="true"} ! male gamete intersection_of: CL:0000408 ! male gamete intersection_of: RO:0002215 GO:0030317 ! capable_of sperm motility intersection_of: RO:0002215 GO:0048240 ! capable_of sperm capacitation relationship: develops_from CL:0000018 ! spermatid relationship: RO:0002215 GO:0030317 ! capable_of sperm motility relationship: RO:0002215 GO:0048240 ! capable_of sperm capacitation [Term] id: CL:0000020 name: spermatogonium namespace: cell def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A05.360.490.890.900] xref: BTO:0000958 xref: CALOHA:TS-2193 xref: EMAPA:31482 xref: FBbt:00004935 xref: FMA:72291 is_a: CL:0000015 ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001394 ! diploid intersection_of: bearer_of PATO:0001501 ! immature relationship: bearer_of PATO:0001394 ! diploid relationship: bearer_of PATO:0001501 ! immature [Term] id: CL:0000021 name: female germ cell namespace: cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 ! capable_of oogenesis relationship: RO:0002215 GO:0048477 ! capable_of oogenesis [Term] id: CL:0000022 name: female germ line stem cell namespace: cell is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0017145 ! capable_of stem cell division relationship: RO:0002215 GO:0017145 ! capable_of stem cell division [Term] id: CL:0000023 name: oocyte namespace: cell def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FBbt:00004886 xref: FMA:18644 xref: WBbt:0006797 is_a: CL:0000021 {is_inferred="true"} ! female germ cell relationship: participates_in GO:0007143 ! female meiosis [Term] id: CL:0000024 name: oogonial cell namespace: cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] xref: FMA:83673 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0007067 ! capable_of mitosis relationship: develops_from CL:0000670 ! primordial germ cell relationship: RO:0002215 GO:0007067 ! capable_of mitosis [Term] id: CL:0000025 name: egg cell namespace: cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FBbt:00000034 xref: FMA:67343 xref: MA:0000388 is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: develops_from CL:0000023 ! oocyte relationship: participates_in GO:0007143 ! female meiosis [Term] id: CL:0000026 name: invertebrate nurse cell namespace: cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391] synonym: "nurse cell" RELATED [] xref: BTO:0000953 xref: FBbt:00004878 is_a: CL:0000039 ! germ line cell is_a: CL:0000412 ! polyploid cell relationship: develops_from CL:0000722 ! cystoblast [Term] id: CL:0000027 name: smooth muscle cell neural crest derived namespace: cell is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000028 name: CNS neuron (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000540 ! neuron relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000029 name: neuron neural crest derived namespace: cell is_a: CL:0000540 {is_inferred="true"} ! neuron intersection_of: CL:0000540 ! neuron intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000030 name: glioblast namespace: cell xref: FBbt:00005145 is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000031 name: neuroblast namespace: cell def: "A cell that will develop into a neuron often after a migration phase." [http://en.wikipedia.org/wiki/Neuroblast] {editor="GOC:NV"} xref: BTO:0000930 xref: FBbt:00005146 xref: FMA:70563 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000032 name: neuroplacodal cell namespace: cell def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256] synonym: "neural placode cell" EXACT [] is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000033 name: apocrine cell namespace: cell def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000034 name: stem cell namespace: cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A11.872] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0017145 ! capable_of stem cell division relationship: RO:0002215 GO:0017145 ! capable_of stem cell division [Term] id: CL:0000035 name: single fate stem cell namespace: cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000036 name: epithelial fate stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000037 name: hematopoietic stem cell namespace: cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 xref: FMA:86475 xref: VHOG:0001485 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0002244 ! capable_of hematopoietic progenitor cell differentiation intersection_of: RO:0002215 GO:0048103 ! capable_of somatic stem cell division relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0002244 ! capable_of hematopoietic progenitor cell differentiation relationship: RO:0002215 GO:0048103 ! capable_of somatic stem cell division [Term] id: CL:0000038 name: erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation [Term] id: CL:0000039 name: germ line cell namespace: cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: ubprop:upper_level is_a: CL:0000548 ! animal cell disjoint_from: CL:0002371 ! somatic cell relationship: RO:0002215 GO:0022414 ! capable_of reproductive process [Term] id: CL:0000040 name: monoblast namespace: cell def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. synonym: "CFU-M" RELATED [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: CALOHA:TS-1195 xref: FMA:83553 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part GO:0000791 ! euchromatin intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part GO:0000791 ! euchromatin relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation [Term] id: CL:0000041 name: mature eosinophil namespace: cell def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000771 ! eosinophil intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: has_part PR:000007152 ! eosinophil peroxidase intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_part PR:000014046 ! non-secretory ribonuclease intersection_of: has_part PR:000014047 ! eosinophil cationic protein intersection_of: has_part PR:000022006 ! eosinophil granule major basic protein intersection_of: has_plasma_membrane_part PR:000009129 ! integrin alpha-4 intersection_of: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II intersection_of: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response intersection_of: RO:0002215 GO:0045730 ! capable_of respiratory burst relationship: develops_from CL:0000774 ! band form eosinophil relationship: has_part CP:0000025 ! lobed nucleus relationship: has_part PR:000007152 ! eosinophil peroxidase relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_part PR:000014046 ! non-secretory ribonuclease relationship: has_part PR:000014047 ! eosinophil cationic protein relationship: has_part PR:000022006 ! eosinophil granule major basic protein relationship: has_plasma_membrane_part PR:000009129 ! integrin alpha-4 relationship: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response relationship: RO:0002215 GO:0045730 ! capable_of respiratory burst [Term] id: CL:0000042 name: neutrophilic myeloblast namespace: cell def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [GOC:add, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic granuloblast" RELATED [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000010799 ! myb proto-oncogene protein intersection_of: has_part PR:000014362 ! runt-related transcription factor 1 intersection_of: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation relationship: develops_from CL:0000834 ! neutrophil progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000010799 ! myb proto-oncogene protein relationship: has_part PR:000014362 ! runt-related transcription factor 1 relationship: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation [Term] id: CL:0000043 name: mature basophil namespace: cell alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002242 ! nucleate cell is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000767 ! basophil intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response intersection_of: RO:0002215 GO:0002351 ! capable_of serotonin production involved in inflammatory response intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation intersection_of: RO:0002215 GO:0032616 ! capable_of interleukin-13 production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production intersection_of: RO:0002215 GO:0048295 ! capable_of positive regulation of isotype switching to IgE isotypes relationship: develops_from CL:0000770 ! band form basophil relationship: has_part CP:0000025 ! lobed nucleus relationship: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response relationship: RO:0002215 GO:0002351 ! capable_of serotonin production involved in inflammatory response relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: RO:0002215 GO:0032616 ! capable_of interleukin-13 production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: RO:0002215 GO:0048295 ! capable_of positive regulation of isotype switching to IgE isotypes [Term] id: CL:0000045 name: obsolete thymus processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. is_obsolete: true [Term] id: CL:0000046 name: obsolete bursa processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead. is_obsolete: true [Term] id: CL:0000047 name: neuronal stem cell namespace: cell def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [GOC:tfm, http://en.wikipedia.org/wiki/Neural_stem_cell, MESH:D058953, PMID:15247488] synonym: "neural stem cell" EXACT [] synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000048 name: multi fate stem cell namespace: cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: RO:0002215 GO:0030154 ! capable_of cell differentiation relationship: RO:0002215 GO:0030154 ! capable_of cell differentiation [Term] id: CL:0000049 name: common myeloid progenitor namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). synonym: "CFU-GEMM" RELATED [ISBN:0878932437] synonym: "CFU-S" RELATED [ISBN:0878932437] synonym: "CMP" EXACT [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation intersection_of: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor relationship: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation relationship: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation [Term] id: CL:0000051 name: common lymphoid progenitor namespace: cell alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. synonym: "CLP" EXACT [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation relationship: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation [Term] id: CL:0000052 name: totipotent stem cell namespace: cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000054 name: bone matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000055 name: non-terminally differentiated cell namespace: cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: define using PATO mulit-potent or oligopotent? synonym: "blast cell" EXACT [] xref: BTO:0000125 xref: FMA:84782 is_a: CL:0000003 ! native cell [Term] id: CL:0000056 name: myoblast namespace: cell def: "A precursor cell of the myogenic lineage that develops from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes." [GOC:tfm, MESH:A11.635] xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FBbt:00005083 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast namespace: cell def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:A11.329.228, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: VHOG:0001482 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000058 name: chondroblast namespace: cell def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007009 ! prechondroblast relationship: produces UBERON:0002418 ! cartilage tissue [Term] id: CL:0000059 name: ameloblast namespace: cell alt_id: CL:0000053 alt_id: CL:0000139 def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:A11.436.107] comment: non-encoded relationship from VSAO produces VSAO:0000066 synonym: "amelocyte" EXACT [] synonym: "enamel secreting cell" EXACT [] xref: BTO:0001663 xref: FMA:70576 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0000151 ! secretory cell relationship: develops_from CL:0007000 ! preameloblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001752 ! enamel relationship: RO:0002215 GO:0097186 ! capable_of amelogenesis relationship: RO:0002220 UBERON:0001763 ! adjacent_to odontogenic papilla [Term] id: CL:0000060 name: odontoblast namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256] comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. xref: BTO:0001769 xref: CALOHA:TS-0696 xref: FMA:62999 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002159 ! general ecto-epithelial cell relationship: develops_from CL:0007003 ! preodontoblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000061 name: cementoblast namespace: cell alt_id: CL:0000859 def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [GO_REF:0000034, ISBN:0781733901] comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth. synonym: "cementum secreting cell" EXACT [] xref: CALOHA:TS-1164 xref: FMA:63002 is_a: CL:0000062 ! osteoblast is_a: CL:0000151 ! secretory cell relationship: develops_from CL:0007002 ! precementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001753 ! cementum [Term] id: CL:0000062 name: osteoblast namespace: cell def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:A11.329.629] comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 xref: BTO:0001593 xref: CALOHA:TS-0720 xref: FMA:66780 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007010 ! preosteoblast relationship: produces UBERON:0008883 ! osteoid [Term] id: CL:0000063 name: obsolete cell by histology namespace: cell def: "OBSOLETE: A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000064 name: ciliated cell namespace: cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: has_plasma_membrane_part GO:0005929 ! cilium relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000065 name: ependymal cell namespace: cell def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134] synonym: "ependymocyte" EXACT [] xref: BTO:0001724 xref: FMA:70550 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000066 name: epithelial cell namespace: cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A11.436] synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FBbt:00000124 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000548 ! animal cell [Term] id: CL:0000067 name: ciliated epithelial cell namespace: cell def: "An epithelial cell that has a cillia." [GOC:tfm] xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: has_plasma_membrane_part GO:0005929 ! cilium relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000068 name: duct epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000058 ! duct relationship: part_of UBERON:0000058 ! duct [Term] id: CL:0000069 name: branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000070 name: obsolete epithelial cell of gland namespace: cell is_obsolete: true [Term] id: CL:0000071 name: blood vessel endothelial cell namespace: cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] synonym: "cuboidal endothelial cell of vascular tree" EXACT [] is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0004638 ! blood vessel endothelium relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell relationship: part_of UBERON:0004638 ! blood vessel endothelium [Term] id: CL:0000072 name: non-branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000073 name: barrier epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000074 name: obsolete epithem cell namespace: cell def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305] comment: replaced_by: PO:0000066 is_obsolete: true [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000076 name: squamous epithelial cell namespace: cell xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell namespace: cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000078 name: peridermal cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000079 name: stratified epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000357 ! stratified epithelial stem cell [Term] id: CL:0000080 name: circulating cell namespace: cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0000179 ! haemolymphatic fluid [Term] id: CL:0000081 name: blood cell namespace: cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] xref: FMA:62844 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: RO:0002215 GO:0008015 ! capable_of blood circulation [Term] id: CL:0000082 name: epithelial cell of lung namespace: cell synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000115 ! lung epithelium relationship: part_of UBERON:0002048 ! lung [Term] id: CL:0000083 name: epithelial cell of pancreas namespace: cell def: "An epithelial cell of the pancreas." [GOC:tfm] synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0000223 ! endodermal cell relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000084 name: T cell namespace: cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: VHOG:0001479 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 ! capable_of T cell mediated immunity disjoint_from: CL:0000623 ! natural killer cell disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: develops_from CL:0000827 ! pro-T cell relationship: RO:0002215 GO:0002456 ! capable_of T cell mediated immunity [Term] id: CL:0000085 name: germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000086 name: germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004861 is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000087 name: male germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004929 is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000088 name: female germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004873 is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000089 name: male germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000090 name: female germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000091 name: Kupffer cell namespace: cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A11.329.372.588, PMID:15771589, PMID:17105582] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] synonym: "liver macrophage" EXACT [] synonym: "macrophagocytus stellatus" EXACT [] synonym: "stellate cell of von Kupffer" EXACT [] synonym: "von Kupffer cell" EXACT [] xref: BTO:0000685 xref: FMA:14656 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: part_of UBERON:0001281 ! hepatic sinusoid intersection_of: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: part_of UBERON:0001281 ! hepatic sinusoid relationship: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance [Term] id: CL:0000092 name: osteoclast namespace: cell def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: has_part PR:000001850 ! cathepsin K intersection_of: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos intersection_of: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: part_of UBERON:0001474 ! bone element intersection_of: RO:0002215 GO:0045453 ! capable_of bone resorption relationship: develops_from CL:0000576 ! monocyte relationship: has_part PR:000001850 ! cathepsin K relationship: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000007597 ! proto-oncogene c-Fos relationship: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit relationship: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: part_of UBERON:0001474 ! bone element relationship: RO:0002215 GO:0045453 ! capable_of bone resorption [Term] id: CL:0000093 name: obsolete osteochondroclast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using 'osteoclast ; CL:0000092' instead. is_obsolete: true [Term] id: CL:0000094 name: granulocyte namespace: cell def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:A11.118.637.415, MESH:D006098] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: has_part GO:0030141 ! secretory granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8 intersection_of: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: has_part GO:0030141 ! secretory granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8 relationship: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0008015 ! capable_of blood circulation [Term] id: CL:0000095 name: neuron associated cell namespace: cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000096 name: mature neutrophil namespace: cell def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [GOC:add, GOC:tfm, http://www.cap.org, MESH:A11.118.637.415.583, MESH:D009504, PMID:11138776, PMID:12560239, PMID:15514007, PMID:7880385] comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 is_a: CL:0000234 ! phagocyte is_a: CL:0000775 {is_inferred="true"} ! neutrophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000775 ! neutrophil intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001256 ! high affinity interleukin-8 receptor A intersection_of: has_plasma_membrane_part PR:000001257 ! high affinity interleukin-8 receptor B intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1 intersection_of: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: lacks_part PR:000010543 ! myeloperoxidase intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein intersection_of: RO:0002215 GO:0002536 ! capable_of respiratory burst involved in inflammatory response intersection_of: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0032637 ! capable_of interleukin-8 production relationship: develops_from CL:0000560 ! band form neutrophil relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part CP:0000025 ! lobed nucleus relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001256 ! high affinity interleukin-8 receptor A relationship: has_plasma_membrane_part PR:000001257 ! high affinity interleukin-8 receptor B relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1 relationship: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010543 ! myeloperoxidase relationship: lacks_part PR:000010799 ! myb proto-oncogene protein relationship: RO:0002215 GO:0002536 ! capable_of respiratory burst involved in inflammatory response relationship: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0032637 ! capable_of interleukin-8 production [Term] id: CL:0000097 name: mast cell namespace: cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [ISBN:0721601464] synonym: "mastocyte" EXACT [ISBN:0721601464] synonym: "tissue basophil" RELATED [ISBN:068340007X] xref: BTO:0000830 xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_part GO:0030141 ! secretory granule intersection_of: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 intersection_of: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3 intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response intersection_of: RO:0002215 GO:0002539 ! capable_of prostaglandin production involved in inflammatory response intersection_of: RO:0002215 GO:0002660 ! capable_of positive regulation of peripheral tolerance induction intersection_of: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0030210 ! capable_of heparin biosynthetic process relationship: develops_from CL:0000831 ! mast cell progenitor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_part GO:0030141 ! secretory granule relationship: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 relationship: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3 relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response relationship: RO:0002215 GO:0002539 ! capable_of prostaglandin production involved in inflammatory response relationship: RO:0002215 GO:0002660 ! capable_of positive regulation of peripheral tolerance induction relationship: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0030210 ! capable_of heparin biosynthetic process [Term] id: CL:0000098 name: sensory epithelial cell namespace: cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! receptor cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000099 name: interneuron namespace: cell def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A08.663.358] xref: BTO:0003811 xref: FBbt:00005125 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:0000540 ! neuron [Term] id: CL:0000100 name: motor neuron namespace: cell def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:A08.663.655.500, PMID:16875686] synonym: "anterior horn cell" NARROW [] synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000101 name: sensory neuron namespace: cell def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] xref: BTO:0001037 xref: FBbt:00005124 xref: FMA:84649 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron [Term] id: CL:0000102 name: polymodal neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000103 name: bipolar neuron namespace: cell def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442] xref: FMA:67282 is_a: CL:0000099 ! interneuron [Term] id: CL:0000104 name: multipolar neuron namespace: cell def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm] xref: FMA:67287 is_a: CL:0000540 ! neuron [Term] id: CL:0000105 name: pseudounipolar neuron namespace: cell def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm] xref: FMA:67305 is_a: CL:0000540 ! neuron [Term] id: CL:0000106 name: unipolar neuron namespace: cell def: "Neuron with one neurite that extends from the cell body." [FMA:67278, GOC:nv] xref: FMA:67278 is_a: CL:0000540 ! neuron [Term] id: CL:0000107 name: autonomic neuron namespace: cell def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron namespace: cell def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: BTO:0004902 xref: FMA:84796 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron [Term] id: CL:0000109 name: adrenergic neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000110 name: peptidergic neuron namespace: cell is_a: CL:0000540 ! neuron relationship: RO:0002215 GO:0002790 ! capable_of peptide secretion [Term] id: CL:0000111 name: peripheral neuron namespace: cell def: "A neuron that is part of nerve found outside the central nervous system." [ISBN:0721662544] xref: FMA:84664 is_a: CL:0000540 ! neuron [Term] id: CL:0000112 name: columnar neuron namespace: cell synonym: "columnar neuron" RELATED [] is_a: CL:0000540 ! neuron [Term] id: CL:0000113 name: mononuclear phagocyte namespace: cell def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] xref: BTO:0001433 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000114 name: surface ectodermal cell namespace: cell synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000115 name: endothelial cell namespace: cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000116 name: pioneer neuron namespace: cell def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [GOC:cvs, GOC:tfm] xref: FBbt:00005128 is_a: CL:0000540 ! neuron [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) namespace: cell is_a: CL:0000540 ! neuron relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000118 name: basket cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000119 name: Golgi cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000120 name: granule cell namespace: cell xref: BTO:0003393 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000121 name: Purkinje cell namespace: cell def: "The output neuron of the cerebellar cortex." [MESH:A08.186.211.132.810.428.200.212.600] synonym: "cerebellar Purkinje cell" EXACT [] synonym: "cerebellum Purkinje cell" EXACT [] synonym: "Purkinje neuron" EXACT [] synonym: "Purkinje's cell" EXACT [] xref: BTO:0001011 xref: CALOHA:TS-0845 xref: FMA:67969 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000122 name: stellate cell namespace: cell xref: BTO:0002316 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) namespace: cell is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000124 name: glial cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005144 is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000340 ! glioblast (sensu Nematoda and Protostomia) [Term] id: CL:0000125 name: glial cell namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A08.637] synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000030 {comment="It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation."} ! glioblast [Term] id: CL:0000126 name: macroglial cell namespace: cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] synonym: "macrogliocyte" EXACT [] xref: BTO:0000771 xref: CALOHA:TS-2027 xref: FMA:54538 is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:A08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. synonym: "astrocytic glia" EXACT [] xref: BTO:0000099 xref: CALOHA:TS-0060 xref: FMA:54537 is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:A08.637.600, MESH:D009836] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [PMID:8734446] xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 is_a: CL:0000126 {is_inferred="true"} ! macroglial cell intersection_of: CL:0000126 ! macroglial cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000129 name: microglial cell namespace: cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" EXACT [] synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 xref: FMA:54540 is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata) is_a: CL:0000878 ! central nervous system macrophage intersection_of: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: part_of UBERON:0001017 ! central nervous system intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: part_of UBERON:0001017 ! central nervous system relationship: RO:0002215 GO:0045087 ! capable_of innate immune response [Term] id: CL:0000130 name: neuron associated cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000131 name: gut endothelial cell namespace: cell is_a: CL:0000115 ! endothelial cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000132 name: corneal endothelial cell namespace: cell def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [GOC:tfm, MESH:A09.371.060.067.31] xref: CALOHA:TS-0172 xref: FMA:70614 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000133 name: neurectodermal cell namespace: cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal cell namespace: cell alt_id: CL:0002452 def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. synonym: "BMSC" NARROW [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED PLURAL [] synonym: "MSC" RELATED [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000219 ! motile cell is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin intersection_of: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002215 GO:0001649 ! capable_of osteoblast differentiation intersection_of: RO:0002215 GO:0016477 ! capable_of cell migration intersection_of: RO:0002215 GO:0030182 ! capable_of neuron differentiation intersection_of: RO:0002215 GO:0030855 ! capable_of epithelial cell differentiation intersection_of: RO:0002215 GO:0045444 ! capable_of fat cell differentiation intersection_of: RO:0002215 GO:0055007 ! capable_of cardiac muscle cell differentiation intersection_of: RO:0002215 GO:0060591 ! capable_of chondroblast differentiation relationship: has_plasma_membrane_part PR:000001345 ! endoglin relationship: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: RO:0002215 GO:0001649 ! capable_of osteoblast differentiation relationship: RO:0002215 GO:0016477 ! capable_of cell migration relationship: RO:0002215 GO:0030182 ! capable_of neuron differentiation relationship: RO:0002215 GO:0030855 ! capable_of epithelial cell differentiation relationship: RO:0002215 GO:0045444 ! capable_of fat cell differentiation relationship: RO:0002215 GO:0055007 ! capable_of cardiac muscle cell differentiation relationship: RO:0002215 GO:0060591 ! capable_of chondroblast differentiation [Term] id: CL:0000135 name: fibrocyte namespace: cell def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Fibrocyte, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999] comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. xref: FMA:63879 is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II intersection_of: RO:0002215 GO:0045766 ! capable_of positive regulation of angiogenesis relationship: develops_from CL:0000057 ! fibroblast relationship: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002215 GO:0045766 ! capable_of positive regulation of angiogenesis [Term] id: CL:0000136 name: fat cell namespace: cell alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A11.329.114] synonym: "adipocyte" EXACT [] synonym: "adipose cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000137 name: osteocyte namespace: cell def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A11.329.629.500] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 synonym: "bone cell" BROAD [] xref: BTO:0002038 xref: CALOHA:TS-1167 xref: FMA:66779 xref: VSAO:0000124 is_a: CL:0001035 ! bone cell relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0000138 name: chondrocyte namespace: cell def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:A11.329.171] synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000058 ! chondroblast [Term] id: CL:0000140 name: odontocyte namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034] is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000060 ! odontoblast relationship: develops_from CL:0000134 ! mesenchymal cell relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000141 name: cementocyte namespace: cell def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901] comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def). xref: FMA:63003 is_a: CL:0000137 ! osteocyte relationship: develops_from CL:0000061 ! cementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: CL:0000142 name: hyalocyte namespace: cell def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178] synonym: "vitreous cell" RELATED [] xref: BTO:0004271 xref: FMA:70620 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000143 name: guidepost cell namespace: cell is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000144 name: obsolete cell by function namespace: cell def: "OBSOLETE: A classification of cells by their primary end goal or behavior." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000145 name: professional antigen presenting cell namespace: cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. synonym: "APC" BROAD [] is_a: CL:0000473 ! defensive cell relationship: RO:0002215 GO:0002504 ! capable_of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: CL:0000146 name: simple columnar epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000147 name: pigment cell namespace: cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000148 name: melanocyte namespace: cell alt_id: CL:0000572 def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl] synonym: "melanophore" NARROW [] xref: BTO:0000847 xref: CALOHA:TS-0613 xref: FMA:70545 xref: VHOG:0001679 is_a: CL:0000147 {is_inferred="true"} ! pigment cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000147 ! pigment cell intersection_of: has_part GO:0042470 ! melanosome relationship: develops_from CL:0000541 ! melanoblast relationship: has_part GO:0042470 ! melanosome [Term] id: CL:0000149 name: visual pigment cell namespace: cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell namespace: cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000151 name: secretory cell namespace: cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0032940 ! capable_of secretion by cell relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell [Term] id: CL:0000152 name: exocrine cell namespace: cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] xref: FMA:16014 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000153 name: GAG secreting cell namespace: cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] synonym: "hyaluronic acid secreting cell" EXACT [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 ! capable_of protein secretion relationship: RO:0002215 GO:0009306 ! capable_of protein secretion [Term] id: CL:0000155 name: peptic cell namespace: cell def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [GOC:tfm] synonym: "chief cell of stomach" EXACT [] synonym: "gastric chief cell" EXACT [] synonym: "pepsinogen secreting cell" EXACT [] synonym: "zymogenic cell" EXACT [] xref: FMA:62902 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000156 name: obsolete antibody secreting cell namespace: cell def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." [] comment: Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000157 name: surfactant secreting cell namespace: cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis relationship: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis [Term] id: CL:0000158 name: Clara cell namespace: cell def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [GOC:tfm, PMID:12107102, PMID:7905712] synonym: "bronchiolar non-ciliated cell" EXACT [] synonym: "Clara cell of bronchiole" EXACT [] xref: BTO:0004811 xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell intersection_of: CL:0002328 ! bronchial epithelial cell intersection_of: bearer_of PATO:0001789 ! domed intersection_of: has_plasma_membrane_part GO:0005902 ! microvillus intersection_of: RO:0002215 GO:0032940 ! capable_of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis relationship: bearer_of PATO:0001789 ! domed relationship: has_plasma_membrane_part GO:0005902 ! microvillus relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell relationship: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis [Term] id: CL:0000159 name: seromucus secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell namespace: cell def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A03.492.411.369.320] synonym: "chalice cell" EXACT [] xref: BTO:0001540 xref: FMA:13148 xref: http://en.wikipedia.org/wiki/Goblet_cell is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion [Term] id: CL:0000161 name: acid secreting cell namespace: cell is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0046717 ! capable_of acid secretion relationship: RO:0002215 GO:0046717 ! capable_of acid secretion [Term] id: CL:0000162 name: parietal cell namespace: cell def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [GOC:tfm, ISBN:0517223651] synonym: "oxyntic cell" EXACT [] xref: BTO:0001780 xref: FMA:62901 is_a: CL:0000161 ! acid secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000163 name: endocrine cell namespace: cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A06.407] synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0046879 ! capable_of hormone secretion relationship: part_of UBERON:0002368 ! endocrine gland relationship: RO:0002215 GO:0046879 ! capable_of hormone secretion [Term] id: CL:0000164 name: enteroendocrine cell namespace: cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] xref: BTO:0003865 xref: FMA:62930 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell namespace: cell def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A06.688] synonym: "neurosecretory cell" EXACT [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000166 name: chromaffin cell namespace: cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A06.224.161] synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 is_a: CL:0000568 ! APUD cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000167 name: peptide hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 ! capable_of peptide hormone secretion relationship: RO:0002215 GO:0030072 ! capable_of peptide hormone secretion [Term] id: CL:0000168 name: insulin secreting cell namespace: cell xref: BTO:0000783 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030073 ! capable_of insulin secretion relationship: RO:0002215 GO:0030073 ! capable_of insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell namespace: cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. synonym: "B-cell of pancreatic islet" EXACT [FMA:70586] synonym: "beta cell" BROAD [ZFA:0009102] synonym: "beta cell islet" RELATED [MA:0002419] synonym: "beta cell of pancreatic islet" EXACT [FMA:70586] synonym: "insulin-secreting cell" EXACT [FMA:70586] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [FMA:70586] synonym: "pancreatic beta cell" EXACT [FMA:70586] synonym: "pancreatic islet core" EXACT [MA:0002419] synonym: "type B enteroendocrine cell" EXACT [FMA:70586] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 {is_inferred="true"} ! enteroendocrine cell is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: RO:0002215 GO:0030073 ! capable_of insulin secretion relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: RO:0002215 GO:0030073 ! capable_of insulin secretion [Term] id: CL:0000170 name: glucagon secreting cell namespace: cell def: "A cell that secretes glucagon." [GOC:tfm] synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070091 ! capable_of glucagon secretion relationship: RO:0002215 GO:0070091 ! capable_of glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell namespace: cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] synonym: "alpha cell of iselt of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0002067 ! type A enterocrine cell intersection_of: CL:0002067 ! type A enterocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas relationship: RO:0002215 GO:0070091 ! capable_of glucagon secretion [Term] id: CL:0000172 name: somatostatin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070253 ! capable_of somatostatin secretion relationship: RO:0002215 GO:0070253 ! capable_of somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell namespace: cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000502 ! type D enteroendocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000174 name: steroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 ! capable_of steroid hormone secretion relationship: RO:0002215 GO:0035929 ! capable_of steroid hormone secretion [Term] id: CL:0000175 name: luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A05.360.319.114.630.278.400] synonym: "lutein cell" EXACT [] xref: BTO:0003939 xref: FMA:18688 is_a: CL:0000179 ! progesterone secreting cell is_a: CL:0002132 ! stromal cell of ovary relationship: part_of UBERON:0002512 ! corpus luteum relationship: RO:0002215 GO:0042701 ! capable_of progesterone secretion [Term] id: CL:0000176 name: ecdysteroid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045457 ! capable_of ecdysteroid secretion relationship: RO:0002215 GO:0045457 ! capable_of ecdysteroid secretion [Term] id: CL:0000177 name: testosterone secreting cell namespace: cell is_a: CL:0000593 ! androgen secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035936 ! capable_of testosterone secretion relationship: RO:0002215 GO:0035936 ! capable_of testosterone secretion [Term] id: CL:0000178 name: Leydig cell namespace: cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120] comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated synonym: "interstitial cell" BROAD [] synonym: "interstitial cell of Leydig" EXACT [] xref: BTO:0000755 xref: CALOHA:TS-1150 xref: EMAPA:29655 xref: FMA:72297 is_a: CL:0000177 ! testosterone secreting cell relationship: part_of UBERON:0005212 ! testis interstitial tissue [Term] id: CL:0000179 name: progesterone secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0042701 ! capable_of progesterone secretion relationship: RO:0002215 GO:0042701 ! capable_of progesterone secretion [Term] id: CL:0000180 name: estradiol secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035938 ! capable_of estradiol secretion relationship: RO:0002215 GO:0035938 ! capable_of estradiol secretion [Term] id: CL:0000181 name: metabolising cell namespace: cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000182 name: hepatocyte namespace: cell def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:A11.436.348, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000181 ! metabolising cell is_a: CL:0000417 ! endopolyploid cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002107 ! liver relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000183 name: contractile cell namespace: cell def: "A cell whose primary function is to shorten." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000185 name: myoepithelial cell namespace: cell def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544] synonym: "basket epithelial cell" EXACT [] synonym: "myoepitheliocyte" EXACT [] xref: BTO:0002309 xref: CALOHA:TS-2379 xref: FMA:67799 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000186 name: myofibroblast cell namespace: cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469] comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. synonym: "MFB" EXACT [PMID:8731193] is_a: CL:0000183 ! contractile cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000187 name: muscle cell namespace: cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A11.620] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FBbt:00005074 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000056 ! myoblast [Term] id: CL:0000188 name: skeletal muscle cell namespace: cell def: "A somatic cell located in skeletal muscle." [GOC:tfm] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 is_a: CL:0002371 ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000189 name: slow muscle cell namespace: cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908] synonym: "slow muscle fiber" RELATED [ISBN:0815316208] xref: FMA:84448 is_a: CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000857 ! slow muscle myoblast [Term] id: CL:0000190 name: fast muscle cell namespace: cell def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908] synonym: "glycolytic muscle fiber" EXACT [] is_a: CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000858 ! fast muscle myoblast [Term] id: CL:0000192 name: smooth muscle cell namespace: cell alt_id: CL:0000191 def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:A11.620.520, MESH:D032389, PMID:9315361] synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" EXACT [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast [Term] id: CL:0000193 name: cardiac muscle cell (sensu Arthopoda) namespace: cell alt_id: CL:0000466 def: "A striated muscle cell of an arthropod heart that participates in heart contraction." [MESH:A11.620.500] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) [Term] id: CL:0000194 name: obsolete nodal cardiac cell namespace: cell comment: Consider CL:0002072. is_obsolete: true [Term] id: CL:0000195 name: obsolete Purkinje fiber namespace: cell is_obsolete: true [Term] id: CL:0000196 name: flight muscle cell namespace: cell is_a: CL:0008003 ! somatic muscle myotube relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000197 name: receptor cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000198 name: pain receptor cell namespace: cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A08.800.550.700.650] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship synonym: "nociceptor" EXACT [] synonym: "nocireceptor" EXACT [] is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000199 name: mechanoreceptor cell namespace: cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A08.800.550.700.500] synonym: "mechanoreceptor" RELATED [MP:0000972] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050974 ! capable_of detection of mechanical stimulus involved in sensory perception relationship: RO:0002215 GO:0050974 ! capable_of detection of mechanical stimulus involved in sensory perception [Term] id: CL:0000200 name: touch receptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050976 ! capable_of detection of mechanical stimulus involved in sensory perception of touch relationship: RO:0002215 GO:0050976 ! capable_of detection of mechanical stimulus involved in sensory perception of touch [Term] id: CL:0000202 name: auditory hair cell namespace: cell alt_id: CL:0000201 def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A08.663.650.250] comment: In mammals these cells are located in the organ of Corti. synonym: "auditory receptor cell" EXACT [] synonym: "cochlear hair cell" EXACT [] synonym: "inner ear hair cell" EXACT [GO:0060119] synonym: "inner ear receptor cell" EXACT [GO:0060119] xref: FMA:62364 is_a: CL:0002374 ! ear hair cell is_a: CL:0002491 ! auditory epithelial cell relationship: part_of UBERON:0002227 ! spiral organ of cochlea relationship: RO:0002215 GO:0050910 ! capable_of detection of mechanical stimulus involved in sensory perception of sound [Term] id: CL:0000203 name: gravity sensitive cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0070999 ! capable_of detection of mechanical stimulus involved in sensory perception of gravity relationship: RO:0002215 GO:0070999 ! capable_of detection of mechanical stimulus involved in sensory perception of gravity [Term] id: CL:0000204 name: acceleration receptive cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000205 name: thermoreceptor cell namespace: cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:A08.800.550.700.840, MP:0000971] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0050960 ! capable_of detection of temperature stimulus involved in thermoception relationship: RO:0002215 GO:0050960 ! capable_of detection of temperature stimulus involved in thermoception [Term] id: CL:0000206 name: chemoreceptor cell namespace: cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A08.800.550.700.120] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050907 ! capable_of detection of chemical stimulus involved in sensory perception relationship: RO:0002215 GO:0050907 ! capable_of detection of chemical stimulus involved in sensory perception [Term] id: CL:0000207 name: olfactory receptor cell namespace: cell synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: BTO:0004185 xref: FMA:67860 is_a: CL:0000206 ! chemoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050911 ! capable_of detection of chemical stimulus involved in sensory perception of smell relationship: RO:0002215 GO:0050911 ! capable_of detection of chemical stimulus involved in sensory perception of smell [Term] id: CL:0000208 name: pH receptor cell namespace: cell is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000209 name: taste receptor cell namespace: cell def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [GOC:tfm, ISBN:0618947256] synonym: "taste bud cell" EXACT [] xref: FMA:67910 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000362 ! epidermal cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050912 ! capable_of detection of chemical stimulus involved in sensory perception of taste relationship: part_of UBERON:0002025 ! stratum basale of epidermis relationship: RO:0002215 GO:0050912 ! capable_of detection of chemical stimulus involved in sensory perception of taste [Term] id: CL:0000210 name: photoreceptor cell namespace: cell def: "A cell specialized to detect and transduce light." [MESH:A08.663.650.650] xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FBbt:00004211 xref: FMA:86740 is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050962 ! capable_of detection of light stimulus involved in sensory perception relationship: RO:0002215 GO:0050962 ! capable_of detection of light stimulus involved in sensory perception [Term] id: CL:0000211 name: electrically active cell namespace: cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000212 name: absorptive cell namespace: cell def: "A cell that takes up and metabolizes substances." [CL:CVS] is_a: CL:0000003 ! native cell [Term] id: CL:0000213 name: lining cell namespace: cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell namespace: cell def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474] synonym: "hyaluronic acid secreting cell" EXACT [] synonym: "synoviocyte" EXACT [] xref: BTO:0003652 xref: CALOHA:TS-0995 xref: FMA:66786 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint [Term] id: CL:0000215 name: barrier cell namespace: cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000003 ! native cell [Term] id: CL:0000216 name: Sertoli cell namespace: cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A05.360.444.849.789] xref: BTO:0001238 xref: CALOHA:TS-0922 xref: FMA:72298 xref: VHOG:0001348 is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 {is_inferred="true"} ! supportive cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000630 ! supportive cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis [Term] id: CL:0000217 name: insulating cell namespace: cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A08.637.800] synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 is_a: CL:0000217 ! insulating cell is_a: CL:0000328 ! myelin accumulating cell is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell [Term] id: CL:0000219 name: motile cell namespace: cell def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0048870 ! capable_of cell motility relationship: RO:0002215 GO:0048870 ! capable_of cell motility [Term] id: CL:0000220 name: obsolete cell by lineage namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000221 name: ectodermal cell namespace: cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:A16.254.425.273] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000924 ! ectoderm [Term] id: CL:0000222 name: mesodermal cell namespace: cell def: "A cell of the middle germ layer of the embryo." [MESH:A16.254.425.660] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000926 ! mesoderm [Term] id: CL:0000223 name: endodermal cell namespace: cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:A16.254.425.407] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000925 ! endoderm [Term] id: CL:0000224 name: obsolete cell by nuclear number namespace: cell def: "OBSOLETE: A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000225 name: anucleate cell namespace: cell def: "A cell that lacks a nucleus." [FB:ma] synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001405 ! anucleate disjoint_from: CL:0002242 ! nucleate cell relationship: bearer_of PATO:0001405 ! anucleate [Term] id: CL:0000226 name: single nucleate cell namespace: cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000227 name: binucleate cell namespace: cell is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001406 ! binucleate relationship: bearer_of PATO:0001406 ! binucleate [Term] id: CL:0000228 name: multinucleate cell namespace: cell def: "A cell with more than one nucleus." [FB:ma] synonym: "syncitium" EXACT [] synonym: "syncytial cell" EXACT [] synonym: "syncytium" EXACT [] xref: AEO:0000203 xref: WBbt:0008074 is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000229 name: obsolete lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. is_obsolete: true [Term] id: CL:0000230 name: obsolete T lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. is_obsolete: true [Term] id: CL:0000231 name: obsolete B lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000232 name: erythrocyte namespace: cell def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A11.118.290] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: bearer_of PATO:0002039 ! biconcave intersection_of: lacks_part GO:0005840 ! ribosome intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation intersection_of: RO:0002215 GO:0015671 ! capable_of oxygen transport relationship: bearer_of PATO:0002039 ! biconcave relationship: develops_from CL:0000558 ! reticulocyte relationship: lacks_part GO:0005840 ! ribosome relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: RO:0002215 GO:0015671 ! capable_of oxygen transport [Term] id: CL:0000233 name: platelet namespace: cell def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:A11.118.188, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831] comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. synonym: "anucleate thrombocyte" EXACT [] synonym: "blood platelet" EXACT [] synonym: "enucleate thrombocyte" EXACT [] xref: BTO:0000132 xref: CALOHA:TS-0803 xref: FMA:62851 is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001405 ! anucleate intersection_of: bearer_of PATO:0001874 ! discoid intersection_of: RO:0002215 GO:0007596 ! capable_of blood coagulation intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: bearer_of PATO:0001405 ! anucleate relationship: bearer_of PATO:0001874 ! discoid relationship: develops_from CL:0000556 ! megakaryocyte relationship: RO:0002215 GO:0007596 ! capable_of blood coagulation relationship: RO:0002215 GO:0008015 ! capable_of blood circulation [Term] id: CL:0000234 name: phagocyte namespace: cell def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] xref: BTO:0001044 xref: FMA:83806 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis [Term] id: CL:0000235 name: macrophage namespace: cell def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 is_a: CL:0000234 ! phagocyte is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0031268 ! capable_of pseudopodium organization relationship: develops_from CL:0000576 ! monocyte relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0031268 ! capable_of pseudopodium organization [Term] id: CL:0000236 name: B cell namespace: cell def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 xref: VHOG:0001480 is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: RO:0002215 GO:0019724 ! capable_of B cell mediated immunity relationship: develops_from CL:0000826 ! pro-B cell relationship: RO:0002215 GO:0019724 ! capable_of B cell mediated immunity [Term] id: CL:0000237 name: keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000238 name: non keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell [Term] id: CL:0000239 name: brush border epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000240 name: stratified squamous epithelial cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000241 name: stratified cuboidal epithelial cell namespace: cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000242 name: Merkel cell namespace: cell def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A08.800.550.700.500.425] synonym: "Merkel's cell" EXACT [] xref: FMA:70548 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000312 {source="PMID:19782676"} ! keratinocyte relationship: part_of UBERON:0002025 ! stratum basale of epidermis [Term] id: CL:0000243 name: glial cell (sensu Vertebrata) namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A08.637] is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000244 name: transitional epithelial cell namespace: cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544] xref: FMA:66778 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000245 name: obsolete passage cell namespace: cell def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208] comment: replaced_by: PO:0000353 is_obsolete: true [Term] id: CL:0000246 name: Mauthner neuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000247 name: Rohon-Beard neuron namespace: cell def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [VHOG:0001484] synonym: "RB neuron" RELATED [VHOG:0001484] synonym: "Rohon Beard cell" EXACT [VHOG:0001484] synonym: "Rohon-Beard cell" EXACT [] xref: AAO:0010316 xref: EFO:0003711 xref: VHOG:0001484 is_a: CL:0000531 ! primary sensory neuron [Term] id: CL:0000248 name: obsolete microsporocyte namespace: cell def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208] comment: replaced_by: PO:0020047 synonym: "pollen mother cell" EXACT [] synonym: "primary sporogenous cell" EXACT [] is_obsolete: true [Term] id: CL:0000249 name: hatching gland cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000250 name: obsolete megaspore namespace: cell def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208] comment: replaced_by: PO:0020019 is_obsolete: true [Term] id: CL:0000251 name: extramedullary cell namespace: cell is_a: CL:0000101 ! sensory neuron [Term] id: CL:0000252 name: obsolete microspore namespace: cell def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208] comment: replaced_by: PO:0020048 is_obsolete: true [Term] id: CL:0000253 name: eurydendroid cell namespace: cell is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000254 name: obsolete egg cell namespace: cell def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [TAIR:lr] comment: replaced_by: PO:0020094 synonym: "female gametophyte egg cell" EXACT [] is_obsolete: true [Term] id: CL:0000255 name: eukaryotic cell namespace: cell is_a: CL:0000003 ! native cell disjoint_from: CL:0000520 ! prokaryotic cell [Term] id: CL:0000256 name: uric acid accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000257 name: Mycetozoan cell namespace: cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000258 name: obsolete fiber tracheid namespace: cell def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208] comment: replaced_by: PO:0000355 is_obsolete: true [Term] id: CL:0000259 name: aggregate cell namespace: cell def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000260 name: obsolete mucilage cell namespace: cell def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208] comment: replaced_by: PO:0000373 is_obsolete: true [Term] id: CL:0000261 name: anterior cell namespace: cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000262 name: obsolete guard mother cell namespace: cell def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [ISBN:0471245208] comment: replaced_by: PO:0000351 is_obsolete: true [Term] id: CL:0000263 name: vegetative cell (sensu Mycetozoa) namespace: cell def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB] synonym: "amoeba" EXACT [] is_a: CL:0000257 ! Mycetozoan cell [Term] id: CL:0000264 name: obsolete phloem initial namespace: cell def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208] comment: replaced_by: PO:0000400 synonym: "phloem mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000265 name: anterior like cell namespace: cell def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB] synonym: "ALC" EXACT [] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000266 name: obsolete meristemoid namespace: cell def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208] comment: replaced_by: PO:0004011 is_obsolete: true [Term] id: CL:0000267 name: prespore cell namespace: cell def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000268 name: obsolete sieve element namespace: cell def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000269 name: prestalk cell namespace: cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000270 name: obsolete subsidiary cell namespace: cell def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520] comment: replaced_by: PO:0000284 is_obsolete: true [Term] id: CL:0000271 name: prestalk A cell namespace: cell def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstA" EXACT [] synonym: "pstAO" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000272 name: obsolete cambial initial namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208] comment: replaced_by PO:0000295 is_obsolete: true [Term] id: CL:0000273 name: prestalk AB cell namespace: cell def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstAB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000275 name: prestalk B cell namespace: cell def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB] synonym: "pstB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000276 name: obsolete sclerenchyma cell namespace: cell def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208] comment: replaced_by: PO:0000077 is_obsolete: true [Term] id: CL:0000277 name: obsolete prestalk I cell namespace: cell def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB] comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology. is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000278 name: obsolete central cell namespace: cell def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr] comment: replaced_by: PO:0020090 is_obsolete: true [Term] id: CL:0000279 name: prestalk 0 cell namespace: cell def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000280 name: obsolete generative cell namespace: cell def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr] comment: replaced_by: PO:0020097 is_obsolete: true [Term] id: CL:0000281 name: pstAB/ALC namespace: cell def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000282 name: obsolete trichome namespace: cell def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806] comment: replaced_by: PO:0000282 is_obsolete: true [Term] id: CL:0000283 name: pstO/ALC namespace: cell def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000284 name: obsolete companion cell namespace: cell def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322] comment: replaced_by: PO:0000071 is_obsolete: true [Term] id: CL:0000285 name: stalk cell namespace: cell def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000286 name: hyphal cell namespace: cell def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X] is_a: CL:0000521 ! fungal cell [Term] id: CL:0000287 name: eye photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye [Term] id: CL:0000288 name: obsolete synergid namespace: cell def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208] comment: replaced_by: PO:0000191 is_obsolete: true [Term] id: CL:0000289 name: chemotactic amoeboid cell (sensu Mycetozoa) namespace: cell def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) is_a: CL:0000732 ! amoeboid cell [Term] id: CL:0000290 name: obsolete xylem fiber cell namespace: cell def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208] comment: replaced_by: PO:0000274 is_obsolete: true [Term] id: CL:0000291 name: spore (sensu Mycetozoa) namespace: cell def: "Dormant cell protected by a tri-layer spore coat. The spore has an elliptical shape and is approximately 6-9 microns by 3 microns." [DDB_REF:5048, DictyBase:DDB, PMID:4338436] xref: DDANAT:0000414 is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000292 name: obsolete guard cell namespace: cell def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208] comment: replaced_by: PO:0000293 synonym: "stomatal guard cell" EXACT [] is_obsolete: true [Term] id: CL:0000293 name: structural cell namespace: cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000003 ! native cell [Term] id: CL:0000294 name: obsolete sieve cell namespace: cell def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000295 name: somatotropin secreting cell namespace: cell alt_id: CL:0000471 def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl] synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030252 ! capable_of growth hormone secretion relationship: RO:0002215 GO:0030252 ! capable_of growth hormone secretion [Term] id: CL:0000296 name: obsolete vegetative cell namespace: cell def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr] comment: replaced_by: PO:0020099 is_obsolete: true [Term] id: CL:0000297 name: obsolete socket cell namespace: cell def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806] comment: replaced_by: PO:0000115 is_obsolete: true [Term] id: CL:0000298 name: obsolete xylem element namespace: cell def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [ISBN:0471245208] comment: replaced_by: PO:0000273 is_obsolete: true [Term] id: CL:0000299 name: obsolete trichoblast namespace: cell def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208] comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262). is_obsolete: true [Term] id: CL:0000300 name: gamete namespace: cell def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FBbt:00005412 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0009566 ! capable_of fertilization relationship: bearer_of PATO:0001375 ! haploid relationship: RO:0002215 GO:0009566 ! capable_of fertilization [Term] id: CL:0000301 name: pole cell namespace: cell xref: FBbt:00000092 is_a: CL:0000670 ! primordial germ cell [Term] id: CL:0000302 name: obsolete IgM B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000303 name: obsolete IgG B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000304 name: obsolete IgA B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000305 name: obsolete IgE B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000306 name: crystallin accumulating cell namespace: cell synonym: "lens cell" EXACT [] xref: FBbt:00004193 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell namespace: cell alt_id: CL:1000474 def: "An epithelial cell found in the trachea." [GOC:tfm] comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' synonym: "tracheocyte" EXACT [] xref: FMA:74793 is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from CL:0000377 ! tracheoblast relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:0000308 name: metal ion accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000309 name: copper accumulating cell namespace: cell synonym: "cuprophilic cell" EXACT [] is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000310 name: iron accumulating cell namespace: cell is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000312 name: keratinocyte namespace: cell alt_id: CL:0002185 def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:A11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116] comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. synonym: "keratinized cell of epidermis" EXACT [] synonym: "malpighian cell" EXACT [] xref: BTO:0000667 xref: CALOHA:TS-0500 xref: FMA:62879 is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell is_a: CL:0000362 {is_inferred="true"} ! epidermal cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis relationship: RO:0002215 GO:0002775 ! capable_of antimicrobial peptide production relationship: RO:0002215 GO:0002776 ! capable_of antimicrobial peptide secretion relationship: RO:0002215 GO:0090023 ! capable_of positive regulation of neutrophil chemotaxis [Term] id: CL:0000313 name: serous secreting cell namespace: cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000314 name: milk secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000315 name: tears secreting cell namespace: cell def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A12.200.882] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000316 name: obsolete ray initial namespace: cell def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208] comment: replaced_by: PO:0000082 is_obsolete: true [Term] id: CL:0000317 name: sebum secreting cell namespace: cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A12.200.702] is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland [Term] id: CL:0000318 name: sweat secreting cell namespace: cell def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A12.200.849] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000319 name: mucus secreting cell namespace: cell synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070254 ! capable_of mucus secretion relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion [Term] id: CL:0000320 name: obsolete megasporocyte namespace: cell def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208] comment: replaced_by: PO:0000431 synonym: "archesporial cell" EXACT [] synonym: "megaspore mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000321 name: seminal fluid secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000322 name: pneumocyte namespace: cell def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144] synonym: "alveolar epithelial cell" EXACT [] synonym: "pneumonocyte" EXACT [] xref: BTO:0000395 xref: CALOHA:TS-2168 xref: FMA:62499 is_a: CL:0010003 ! epithelial cell of alveolus of lung relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium [Term] id: CL:0000323 name: lysozyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000324 name: metanephric mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000325 name: stuff accumulating cell namespace: cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: ubprop:upper_level is_a: CL:0000003 ! native cell [Term] id: CL:0000326 name: glycogen accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell is_a: CL:0000499 ! stromal cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070278 ! capable_of extracellular matrix constituent secretion relationship: RO:0002215 GO:0070278 ! capable_of extracellular matrix constituent secretion [Term] id: CL:0000328 name: myelin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000329 name: oxygen accumulating cell namespace: cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0015671 ! capable_of oxygen transport relationship: RO:0002215 GO:0015671 ! capable_of oxygen transport [Term] id: CL:0000330 name: obsolete collenchymal cell namespace: cell def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208] comment: replaced_by: PO:0000075 is_obsolete: true [Term] id: CL:0000331 name: obsolete tracheid namespace: cell def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208] comment: replaced_by: PO:0000301 is_obsolete: true [Term] id: CL:0000332 name: obsolete atrichoblast namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819] comment: replaced_by: PO:0020090 synonym: "non-hair cell" RELATED [] is_obsolete: true [Term] id: CL:0000333 name: migratory neural crest cell namespace: cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) namespace: cell synonym: "yeast-form" RELATED [] xref: BTO:0002307 xref: FAO:0000032 is_a: CL:0000521 ! fungal cell [Term] id: CL:0000335 name: mesenchyme condensation cell namespace: cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0000134 ! mesenchymal cell [Term] id: CL:0000336 name: adrenal medulla chromaffin cell namespace: cell alt_id: CL:1000422 def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland] synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262] xref: FMA:69262 is_a: CL:0000457 ! biogenic amine secreting cell is_a: CL:1000426 ! chromaffin cell of adrenal gland intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: develops_from CL:0000011 ! migratory trunk neural crest cell relationship: part_of UBERON:0001236 ! adrenal medulla [Term] id: CL:0000337 name: neuroblast (sensu Vertebrata) namespace: cell def: "An embryonic cell that develops into a nerve cell or neuron." [FMA:70563] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) namespace: cell synonym: "neuroblast" BROAD [] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) namespace: cell def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256] synonym: "spongioblast" EXACT [] xref: FMA:70564 is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) [Term] id: CL:0000340 name: glioblast (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000030 ! glioblast is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000147 ! pigment cell [Term] id: CL:0000342 name: pigment cell (sensu Vertebrata) namespace: cell def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000343 name: visual pigment cell (sensu Vertebrata) namespace: cell def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm] xref: FMA:63846 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: RO:0002215 GO:0050908 ! capable_of detection of light stimulus involved in visual perception relationship: RO:0002215 GO:0050908 ! capable_of detection of light stimulus involved in visual perception [Term] id: CL:0000344 name: obsolete non-visual cell (sensu Vertebrata) namespace: cell is_obsolete: true [Term] id: CL:0000345 name: dental papilla cell namespace: cell def: "A small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544] is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001763 ! odontogenic papilla [Term] id: CL:0000346 name: hair follicle dermal papilla cell namespace: cell def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [GOC:tfm, PMID:9893172] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000412 ! dermal papilla relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: part_of UBERON:0000412 ! dermal papilla [Term] id: CL:0000347 name: scleral cell namespace: cell def: "A cell of the sclera of the eye." [GOC:add] is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye namespace: cell def: "A cell of the choroid of the eye." [GOC:add] is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001776 ! optic choroid [Term] id: CL:0000349 name: extraembryonic cell namespace: cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000350 name: amnioserosal cell namespace: cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0010302 ! amnioserosa relationship: part_of UBERON:0010302 ! amnioserosa [Term] id: CL:0000351 name: trophoblast cell namespace: cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A11.936] synonym: "trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0000358 ! blastocyst relationship: part_of UBERON:0000358 ! blastocyst [Term] id: CL:0000352 name: epiblast cell namespace: cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell namespace: cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A11.104] synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000354 name: blastemal cell namespace: cell synonym: "blastema cell" EXACT [] xref: ncithesaurus:Blastemal_Cell is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0000355 name: skeletal muscle stem cell namespace: cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types. Distinct cell type from satellite cell." [PMID:18282570] xref: FMA:86767 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0000188 ! skeletal muscle cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000356 name: hair matrix stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000357 name: stratified epithelial stem cell namespace: cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000358 name: sphincter associated smooth muscle cell namespace: cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004590 ! sphincter muscle relationship: part_of UBERON:0004590 ! sphincter muscle [Term] id: CL:0000359 name: vascular associated smooth muscle cell namespace: cell def: "A smooth muscle cell assocatiated with the vasculature." [GOC:dsd, GOC:tfm] synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature [Term] id: CL:0000360 name: morula cell namespace: cell def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A16.254.270.550] is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0000085 ! morula [Term] id: CL:0000361 name: gastrula cell namespace: cell def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A16.254.412] is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0004734 ! gastrula [Term] id: CL:0000362 name: epidermal cell namespace: cell alt_id: CL:1000396 def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007376 ! outer epithelial layer relationship: part_of UBERON:0007376 ! outer epithelial layer [Term] id: CL:0000363 name: obsolete axial cell namespace: cell def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208] comment: replaced_by: PO:0000081 is_obsolete: true [Term] id: CL:0000364 name: obsolete ray cell namespace: cell def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000365 name: zygote namespace: cell def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000366 name: obsolete sperm cell (sensu Viridiplantae) namespace: cell def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [ISBN:0471245208] comment: replaced_by: PO:0000084 synonym: "gametophyte sperm cell" RELATED [] synonym: "male gametophyte sperm cell" RELATED [] synonym: "pollen germ cell " RELATED [] is_obsolete: true [Term] id: CL:0000367 name: sheath cell (sensu Nematoda) namespace: cell synonym: "glial cell (sensu Nematoda)" RELATED [] is_a: CL:0000619 ! support cell (sensu Nematoda) [Term] id: CL:0000368 name: obsolete myrosin cell namespace: cell def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208] comment: replaced_by: PO:0000352 is_obsolete: true [Term] id: CL:0000370 name: obsolete transfer cell namespace: cell def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208] comment: replaced_by: PO:0000078 synonym: "intermediary cell" RELATED [] is_obsolete: true [Term] id: CL:0000371 name: protoplast namespace: cell def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X] is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000372 name: tormogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [ISBN:978-0801481253] synonym: "socket cell" BROAD [ISBN:978-0801481253] xref: FBbt:00005171 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) [Term] id: CL:0000373 name: histoblast namespace: cell xref: FBbt:00001789 is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000374 name: trichogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [ISBN:978-0801481253] synonym: "hair cell" BROAD [] xref: BTO:0004744 xref: FBbt:00005169 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) [Term] id: CL:0000375 name: obsolete osteoprogenitor cell namespace: cell xref: BTO:0002051 is_obsolete: true replaced_by: CL:0007010 [Term] id: CL:0000376 name: humidity receptor cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000377 name: tracheoblast namespace: cell is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000378 name: support cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000379 name: sensory processing neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000380 name: thecogen cell namespace: cell def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173] synonym: "fly sheath cell" EXACT [] is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000381 name: neurosecretory neuron namespace: cell xref: FBbt:00005130 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000382 name: scolopidium namespace: cell synonym: "scolopale cell" EXACT [] xref: FBbt:00005217 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000383 name: nephrogenic mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000384 name: ligament cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005062 is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) [Term] id: CL:0000386 name: attachment cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000387 name: hemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005063 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) relationship: RO:0002215 GO:0035010 {source="PMID:18025161"} ! capable_of encapsulation of foreign target [Term] id: CL:0000388 name: tendon cell namespace: cell def: "A fibrocyte that is part of a tendon." [GOC:tfm] synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] is_a: CL:0000135 {is_inferred="true"} ! fibrocyte is_a: CL:0000386 ! attachment cell intersection_of: CL:0000135 ! fibrocyte intersection_of: part_of UBERON:0000043 ! tendon relationship: part_of UBERON:0000043 ! tendon [Term] id: CL:0000389 name: socket cell (sensu Nematoda) namespace: cell is_a: CL:0000619 ! support cell (sensu Nematoda) is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000081 ! blood cell [Term] id: CL:0000391 name: podocyte (sensu Diptera) namespace: cell def: "An insect immune cell that develops from plasmatocyte." [PMID:12930778] xref: FBbt:00001688 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000394 ! plasmatocyte [Term] id: CL:0000392 name: crystal cell namespace: cell xref: FMA:63847 is_a: CL:0000391 ! podocyte (sensu Diptera) [Term] id: CL:0000393 name: electrically responsive cell namespace: cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000394 name: plasmatocyte namespace: cell xref: FBbt:00001685 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000395 name: procrystal cell namespace: cell xref: FBbt:00001689 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000396 name: lamellocyte namespace: cell xref: FBbt:00001687 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000397 name: ganglion interneuron namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0000045 ! ganglion relationship: part_of UBERON:0000045 ! ganglion [Term] id: CL:0000398 name: polygonal cell namespace: cell xref: FBbt:00001691 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000399 name: obsolete phloem element namespace: cell def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [GOC:tfm] is_obsolete: true [Term] id: CL:0000400 name: obsolete pavement cell namespace: cell def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289] comment: replaced_by: PO:0000332 is_obsolete: true [Term] id: CL:0000401 name: macrophage (sensu Diptera) namespace: cell xref: FBbt:00001686 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000402 name: CNS interneuron namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000404 name: electrically signaling cell namespace: cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000405 name: neuroepidermoblast namespace: cell xref: FBbt:00005148 is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000406 name: CNS short range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000407 name: scolopidial ligament cell namespace: cell xref: FBbt:00005221 is_a: CL:0000384 ! ligament cell [Term] id: CL:0000408 name: male gamete namespace: cell xref: BTO:0001277 xref: CALOHA:TS-0949 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000300 {is_inferred="true"} ! gamete intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0009566 ! capable_of fertilization relationship: bearer_of PATO:0001375 ! haploid relationship: RO:0002215 GO:0009566 ! capable_of fertilization [Term] id: CL:0000409 name: scolopidial sheath cell namespace: cell xref: FBbt:00005219 is_a: CL:0000618 ! sheath cell [Term] id: CL:0000410 name: CNS long range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000411 name: flatworm hypodermal cell namespace: cell def: "An epithelial cell of the hypodermis of flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm] xref: WBbt:0007846 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000412 name: polyploid cell namespace: cell def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000413 name: haploid cell namespace: cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001375 ! haploid relationship: bearer_of PATO:0001375 ! haploid [Term] id: CL:0000414 name: obsolete cell by ploidy namespace: cell def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0000255 consider: CL:0001034 [Term] id: CL:0000415 name: diploid cell namespace: cell def: "A cell whose nucleus has two haploid genomes." [FB:ma] xref: FMA:72300 is_a: CL:0000003 ! native cell [Term] id: CL:0000416 name: polytene cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000417 name: endopolyploid cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000418 name: arcade cell namespace: cell def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tfm, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells] xref: WBbt:0005793 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000419 name: seam cell namespace: cell def: "An epithelial fate stem cell found in flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm] xref: BTO:0003039 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000420 name: syncytial epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000421 name: coelomocyte namespace: cell def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544] xref: BTO:0002856 xref: WBbt:0005751 is_a: CL:0000080 ! circulating cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000422 name: mitogenic signaling cell namespace: cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000423 name: tip cell namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell namespace: cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135] xref: WBbt:0005812 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000425 name: pore cell namespace: cell def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb] is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000426 name: scaffold cell namespace: cell is_a: CL:0000445 ! apoptosis fated cell [Term] id: CL:0000427 name: GLR cell namespace: cell def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm] is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000428 name: yolk cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000429 name: imaginal disc cell namespace: cell is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000430 name: xanthophore namespace: cell def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005002 ! xanthoblast [Term] id: CL:0000431 name: iridophore namespace: cell def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl] synonym: "guanophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005001 ! iridoblast [Term] id: CL:0000432 name: reticular cell namespace: cell def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651] synonym: "reticulum cell" EXACT [] xref: FMA:62877 is_a: CL:0000057 ! fibroblast [Term] id: CL:0000433 name: obsolete functional megaspore namespace: cell def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr] comment: replaced_by: PO:0000244 is_obsolete: true [Term] id: CL:0000434 name: eccrine cell namespace: cell def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000435 name: alkali secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000436 name: vaginal lubricant secreting cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: part_of UBERON:0000996 ! vagina [Term] id: CL:0000437 name: gonadtroph namespace: cell def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651] synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] synonym: "gonadotrope" EXACT [] synonym: "gonadotrope cell" EXACT [] synonym: "gonadotroph" EXACT [] synonym: "gonadotropic cell" EXACT [] synonym: "pituitary delta cell" EXACT [] xref: BTO:0002482 xref: FMA:83100 is_a: CL:0000438 ! luteinizing hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000438 name: luteinizing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0032275 ! capable_of luteinizing hormone secretion relationship: RO:0002215 GO:0032275 ! capable_of luteinizing hormone secretion [Term] id: CL:0000439 name: prolactin secreting cell namespace: cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070459 ! capable_of prolactin secretion relationship: RO:0002215 GO:0070459 ! capable_of prolactin secretion [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell namespace: cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl] synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036160 ! capable_of melanocyte-stimulating hormone secretion relationship: RO:0002215 GO:0036160 ! capable_of melanocyte-stimulating hormone secretion [Term] id: CL:0000441 name: follicle stem cell namespace: cell xref: FBbt:00004903 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000442 name: follicular dendritic cell namespace: cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252] comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. xref: BTO:0004267 xref: FMA:83037 is_a: CL:0000473 ! defensive cell [Term] id: CL:0000443 name: calcitonin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036161 ! capable_of calcitonin secretion relationship: RO:0002215 GO:0036161 ! capable_of calcitonin secretion [Term] id: CL:0000444 name: obliquely striated muscle cell namespace: cell def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [GOC:DOS, PMID:8720463] comment: Examples include the somatic muscles of nemotodes and cephalopods. is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0002479 ! obliquely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0002479 ! obliquely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000445 name: apoptosis fated cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000446 name: chief cell of parathyroid gland namespace: cell def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651] synonym: "parathyroid chief cell" EXACT [] synonym: "parathyroid gland chief cell" EXACT [] synonym: "parathyroid hormone secreting cell" EXACT [] synonym: "principal cell of parathyroid gland" EXACT [] xref: BTO:0004712 xref: CALOHA:TS-2140 xref: FMA:69078 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002260 ! epithelial cell of parathyroid gland [Term] id: CL:0000447 name: carbohydrate secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white fat cell namespace: cell def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500] synonym: "white adipocyte" RELATED [] synonym: "white adipose cell" EXACT [] synonym: "white fat cell" EXACT [] xref: CALOHA:TS-1119 xref: FMA:83434 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002334 ! preadipocyte relationship: part_of UBERON:0001347 ! white adipose tissue [Term] id: CL:0000449 name: brown fat cell namespace: cell def: "A cell from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A10.165.114.322] synonym: "brown adipocyte" EXACT [] synonym: "brown adipose cell" EXACT [] xref: CALOHA:TS-0099 xref: FMA:83435 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002335 ! brown preadipocyte relationship: part_of UBERON:0001348 ! brown adipose tissue [Term] id: CL:0000451 name: dendritic cell namespace: cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: has_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation intersection_of: RO:0002215 GO:0045580 ! capable_of regulation of T cell differentiation disjoint_from: CL:0000542 ! lymphocyte relationship: has_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: RO:0002215 GO:0045580 ! capable_of regulation of T cell differentiation [Term] id: CL:0000452 name: thyroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000453 name: Langerhans cell namespace: cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. synonym: "Langerhans' cell" EXACT [] synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K intersection_of: RO:0002215 GO:0002828 ! capable_of regulation of type 2 immune response relationship: develops_from CL:0000763 ! myeloid cell relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: RO:0002215 GO:0002828 ! capable_of regulation of type 2 immune response [Term] id: CL:0000454 name: epinephrine secreting cell namespace: cell def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093] synonym: "adrenaline secreting cell" EXACT [GO:0048242] synonym: "epinephrin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048242 ! capable_of epinephrine secretion relationship: RO:0002215 GO:0048242 ! capable_of epinephrine secretion [Term] id: CL:0000455 name: obsolete starch sheath cell namespace: cell def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520] comment: replaced_by: PO:0004531 is_obsolete: true [Term] id: CL:0000456 name: mineralocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035931 ! capable_of mineralocorticoid secretion relationship: RO:0002215 GO:0035931 ! capable_of mineralocorticoid secretion [Term] id: CL:0000457 name: biogenic amine secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000458 name: serotonin secreting cell namespace: cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 ! capable_of serotonin secretion relationship: RO:0002215 GO:0001820 ! capable_of serotonin secretion [Term] id: CL:0000459 name: norepinephrin secreting cell namespace: cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] synonym: "noradrenalin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion relationship: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion [Term] id: CL:0000460 name: glucocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035933 ! capable_of glucocorticoid secretion relationship: RO:0002215 GO:0035933 ! capable_of glucocorticoid secretion [Term] id: CL:0000462 name: adepithelial cell namespace: cell xref: FBbt:00003219 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000463 name: epidermal cell (sensu arthropoda) namespace: cell def: "An epidermal cell that secretes chitinous cuticle from its apical side." [FlyBase:ds, ISBN:ISBN\:978-0801481253] comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ. is_a: CL:0000362 ! epidermal cell relationship: develops_from CL:0000464 ! epidermoblast [Term] id: CL:0000464 name: epidermoblast namespace: cell def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311] xref: FBbt:00004994 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000465 name: cardioblast (sensu Arthropoda) namespace: cell xref: FBbt:00001666 is_a: CL:0010021 ! cardiac myoblast [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell namespace: cell alt_id: CL:0000640 def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl] synonym: "ACTH secreting cell" EXACT [GO:0051458] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [GO:0051458] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0051458 ! capable_of corticotropin secretion relationship: RO:0002215 GO:0051458 ! capable_of corticotropin secretion [Term] id: CL:0000468 name: neuroglioblast namespace: cell xref: FBbt:00005147 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000469 name: ganglion mother cell namespace: cell xref: FBbt:00005149 is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000470 name: digestive enzyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000472 name: obsolete chlorenchyma cell namespace: cell def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208] comment: replaced_by: PO:0000076 is_obsolete: true [Term] id: CL:0000473 name: defensive cell namespace: cell def: "A cell whose primary function is to protect the organism." [JB:jb] is_a: CL:0000003 ! native cell [Term] id: CL:0000474 name: pericardial nephrocyte namespace: cell def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [FBbt:00003184, GO:0061320, GOC:tfm, PMID:19783135] synonym: "pericardial cell" NARROW [FBbt:00005058, GO:0061320] xref: FBbt:00005058 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000475 name: obsolete degenerate megaspore namespace: cell def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr] comment: replaced_by: PO:0000245 is_obsolete: true [Term] id: CL:0000476 name: thyrotroph namespace: cell def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis relationship: RO:0002215 GO:0070460 ! capable_of thyroid-stimulating hormone secretion [Term] id: CL:0000477 name: follicle cell namespace: cell comment: Editors note: check this. Currently used in goxp synonym: "ovarian follicle cell" EXACT [GO:0007297] xref: FBbt:00004904 is_a: CL:0000075 ! columnar/cuboidal epithelial cell relationship: develops_from CL:0000441 ! follicle stem cell [Term] id: CL:0000478 name: oxytocin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000479 name: vasopressin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000480 name: secretin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000481 name: cholecystokin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000482 name: juvenile hormone secreting cell namespace: cell def: "An endocrine cell that secretes juvenile hormone." [GO:tfm] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045443 ! capable_of juvenile hormone secretion relationship: RO:0002215 GO:0045443 ! capable_of juvenile hormone secretion [Term] id: CL:0000483 name: bombesin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000484 name: connective tissue type mast cell namespace: cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000097 ! mast cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue [Term] id: CL:0000485 name: mucosal type mast cell namespace: cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell intersection_of: CL:0000097 ! mast cell intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response [Term] id: CL:0000486 name: garland cell namespace: cell def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [fbbt:00005059, GOC:tfm, PMID:19783135] synonym: "garland nephrocyte" BROAD [GO:0061321] xref: BTO:0004596 xref: FBbt:00005059 is_a: CL:0000227 ! binucleate cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000487 name: oenocyte namespace: cell def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397] xref: FBbt:00004995 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000488 name: visible light photoreceptor cell namespace: cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009584 ! capable_of detection of visible light relationship: RO:0002215 GO:0009584 ! capable_of detection of visible light [Term] id: CL:0000489 name: scotopic photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000490 name: photopic photoreceptor cell namespace: cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000491 name: obsolete cytotoxic T cell namespace: cell def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." [] comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. is_obsolete: true [Term] id: CL:0000492 name: CD4-positive helper T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A11.118.637.555.567.569.200.400] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0000493 name: obsolete regulatory T cell namespace: cell def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." [] comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. is_obsolete: true [Term] id: CL:0000494 name: UV sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that detects ultraviolet light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009589 ! capable_of detection of UV relationship: RO:0002215 GO:0009589 ! capable_of detection of UV [Term] id: CL:0000495 name: blue sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to blue light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000496 name: green sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to green light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000497 name: red sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to red light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000498 name: inhibitory interneuron namespace: cell def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron] xref: FMA:84776 is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell namespace: cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A11.329.830] xref: BTO:0002064 xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000500 name: follicular epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000501 name: granulosa cell namespace: cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A05.360.319.114.630.535.200] synonym: "granulosa cell of ovary" EXACT [] xref: BTO:0000542 xref: CALOHA:TS-0729 xref: FMA:18718 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary [Term] id: CL:0000502 name: type D enteroendocrine cell namespace: cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A03.492.766.440.175] synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell relationship: RO:0002215 GO:0070253 ! capable_of somatostatin secretion [Term] id: CL:0000503 name: theca cell namespace: cell def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A05.360.319.114.630.535.400] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000499 ! stromal cell is_a: CL:0000593 ! androgen secreting cell [Term] id: CL:0000504 name: enterochromaffin-like cell namespace: cell def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:A06.224.365] comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. synonym: "ECL" EXACT [] xref: BTO:0002692 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell [Term] id: CL:0000505 name: substance P secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes substance P." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell namespace: cell def: "An endorphine cell that secretes enkephalin." [GO:tfm] is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell namespace: cell def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A03.492.766.440.300] synonym: "G cell " EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell is_a: CL:0002180 ! mucous cell of stomach relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum [Term] id: CL:0000509 name: gastrin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000510 name: paneth cell namespace: cell def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A03.492.411.369.700] xref: BTO:0000993 xref: FMA:62897 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0000323 ! lysozyme secreting cell is_a: CL:0002563 ! intestinal epithelial cell relationship: part_of UBERON:0001277 ! intestinal epithelium [Term] id: CL:0000511 name: androgen binding protein secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm] is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000512 name: paracrine cell namespace: cell def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [GOC:tfm, ISBN:0198529171] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000513 name: cardiac muscle myoblast namespace: cell alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A11.635.470] xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell relationship: part_of UBERON:0001133 ! cardiac muscle tissue relationship: RO:0002203 CL:0000746 ! develops into cardiac muscle cell [Term] id: CL:0000514 name: smooth muscle myoblast namespace: cell def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A11.635.510, MESH:D032390] synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 {is_inferred="true"} ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000192 ! develops into smooth muscle cell relationship: RO:0002203 CL:0000192 ! develops into smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast namespace: cell def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 {is_inferred="true"} ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber relationship: develops_from CL:0000355 ! skeletal muscle stem cell relationship: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber [Term] id: CL:0000516 name: perineuronal satellite cell namespace: cell def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:A08.340.685] synonym: "perineural satellite cell" EXACT [] synonym: "perineuronal satellite oligodendroglial cell" EXACT [] synonym: "satellite oligodendrocyte" EXACT [] xref: FMA:54550 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000517 name: macrophage derived foam cell namespace: cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) namespace: cell def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) namespace: cell def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [GOC:tfm] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000520 name: prokaryotic cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000521 name: fungal cell namespace: cell is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000548 ! animal cell [Term] id: CL:0000522 name: obsolete spore namespace: cell def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000523 name: mononuclear cytotrophoblast cell namespace: cell def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908] synonym: "Langhans' cell" EXACT [] xref: FMA:83042 is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000524 name: spheroplast namespace: cell def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A11.868] synonym: "sphaeroplast" EXACT [] is_a: CL:0000371 ! protoplast [Term] id: CL:0000525 name: syncytiotrophoblast cell namespace: cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] synonym: "plasmidotrophoblast" EXACT [] synonym: "syncytial trophoblast" EXACT [] synonym: "syntrophoblast" EXACT [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000526 name: afferent neuron namespace: cell def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A08.663.650] synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000540 ! neuron [Term] id: CL:0000527 name: efferent neuron namespace: cell def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A08.663.655] synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000528 name: nitrergic neuron namespace: cell def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:A08.663.748] xref: FMA:84792 is_a: CL:0000540 ! neuron [Term] id: CL:0000529 name: pigmented epithelial cell namespace: cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000531 name: primary sensory neuron namespace: cell is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000532 name: CAP motoneuron namespace: cell is_a: CL:0000533 ! primary motor neuron [Term] id: CL:0000533 name: primary motor neuron namespace: cell xref: FMA:83619 is_a: CL:0000100 ! motor neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000534 name: primary interneuron namespace: cell is_a: CL:0000099 ! interneuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000535 name: secondary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000536 name: secondary motor neuron namespace: cell xref: FMA:83620 is_a: CL:0000100 ! motor neuron is_a: CL:0000535 ! secondary neuron [Term] id: CL:0000537 name: obsolete antipodal cell namespace: cell def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208] comment: replaced_by: PO:0020093 is_obsolete: true [Term] id: CL:0000538 name: obsolete epidermal initial namespace: cell def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr] comment: replaced_by: PO:0000349 is_obsolete: true [Term] id: CL:0000539 name: obsolete idioblast namespace: cell def: "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000540 name: neuron namespace: cell def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:A08.663, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FBbt:00005106 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000031 ! neuroblast relationship: RO:0002215 GO:0019226 ! capable_of transmission of nerve impulse [Term] id: CL:0000541 name: melanoblast namespace: cell def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl] comment: Derived from UBERON:0002342 neural crest. xref: BTO:0003217 xref: FMA:83377 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000542 name: lymphocyte namespace: cell def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: VHOG:0001535 is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000738 ! leukocyte intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: lacks_part GO:0030141 ! secretory granule disjoint_from: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0000792 ! heterochromatin relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000543 name: obsolete sieve tube member namespace: cell def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208] comment: replaced_by: PO:0000289 synonym: "sieve tube element" EXACT [] is_obsolete: true [Term] id: CL:0000544 name: slowly adapting mechanoreceptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000545 name: T-helper 1 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [PMID:9419219] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 CD4+ T cell" EXACT [PMID:22343568] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: BTO:0001678 xref: FMA:84382 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21 intersection_of: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001835 ! T-box transcription factor TBX21 relationship: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000546 name: T-helper 2 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [PMID:9419219] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000547 name: proerythroblast namespace: cell def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A11.118.290.350.200, PMID:1638021] synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0005634 ! nucleus intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: develops_from CL:0000038 ! erythroid progenitor cell relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0005634 ! nucleus relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G [Term] id: CL:0000548 name: animal cell namespace: cell subset: ubprop:upper_level is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000549 name: basophilic erythroblast namespace: cell def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000550 name: polychromatophilic erythroblast namespace: cell def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000035 ! polychromatophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000549 ! basophilic erythroblast relationship: has_part CP:0000035 ! polychromatophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000551 name: unimodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000552 name: orthochromatic erythroblast namespace: cell def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation relationship: develops_from CL:0000550 ! polychromatophilic erythroblast relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: participates_in GO:0030263 ! apoptotic chromosome condensation [Term] id: CL:0000553 name: megakaryocyte progenitor cell namespace: cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0007113 ! capable_of endomitotic cell cycle intersection_of: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0007113 ! capable_of endomitotic cell cycle relationship: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation [Term] id: CL:0000554 name: gastrin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000555 name: neuronal brush cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000556 name: megakaryocyte namespace: cell def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 {is_inferred="true"} ! myeloid cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001393 ! euploid intersection_of: part_of UBERON:0002371 ! bone marrow disjoint_from: CL:0000764 ! erythroid lineage cell relationship: bearer_of PATO:0001393 ! euploid relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell relationship: part_of UBERON:0002371 ! bone marrow [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] synonym: "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_part PR:000007857 ! erythroid transcription factor intersection_of: lacks_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: part_of UBERON:0002371 ! bone marrow intersection_of: RO:0002215 GO:0030225 ! capable_of macrophage differentiation intersection_of: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation relationship: develops_from CL:0000049 ! common myeloid progenitor relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_part PR:000007857 ! erythroid transcription factor relationship: lacks_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: part_of UBERON:0002371 ! bone marrow relationship: RO:0002215 GO:0030225 ! capable_of macrophage differentiation relationship: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation [Term] id: CL:0000558 name: reticulocyte namespace: cell def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] xref: BTO:0001173 xref: CALOHA:TS-0864 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002215 GO:0071971 ! capable_of extracellular vesicular exosome assembly relationship: develops_from CL:0000552 ! orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: RO:0002215 GO:0071971 ! capable_of extracellular vesicular exosome assembly [Term] id: CL:0000559 name: promonocyte namespace: cell def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. xref: BTO:0004657 xref: FMA:83551 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: develops_from CL:0000040 ! monoblast relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation [Term] id: CL:0000560 name: band form neutrophil namespace: cell def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: Found in the Band 1 fraction. synonym: "band" BROAD [] synonym: "band cell" BROAD [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" BROAD [] is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000039 ! banded nucleus intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001337 ! complement receptor type 1 intersection_of: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein intersection_of: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4 intersection_of: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007597 ! proto-oncogene c-Fos relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001337 ! complement receptor type 1 relationship: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010799 ! myb proto-oncogene protein relationship: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4 relationship: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase [Term] id: CL:0000561 name: amacrine cell namespace: cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:A08.663.358.050] comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748). synonym: "amacrine neuron" EXACT [] xref: BTO:0004044 xref: FBbt:00005127 xref: FMA:67766 is_a: CL:0000099 ! interneuron [Term] id: CL:0000562 name: nucleate erythrocyte namespace: cell def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 {is_inferred="true"} ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: has_part GO:0005634 ! nucleus relationship: develops_from CL:0002421 ! nucleated reticulocyte relationship: has_part GO:0005634 ! nucleus [Term] id: CL:0000563 name: endospore namespace: cell def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [GOC:tfm, ISBN:0618947256] synonym: "bacterial spore" EXACT [] xref: BTO:0002779 is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte namespace: cell def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] xref: FMA:84196 is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_part PR:000014362 ! runt-related transcription factor 1 intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation relationship: develops_from CL:0000042 ! neutrophilic myeloblast relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_part PR:000014362 ! runt-related transcription factor 1 relationship: lacks_part PR:000009978 ! lactotransferrin relationship: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation [Term] id: CL:0000565 name: fat body cell namespace: cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000181 ! metabolising cell [Term] id: CL:0000566 name: angioblastic mesenchymal cell namespace: cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: has_plasma_membrane_part PR:000001444 ! cadherin-5 intersection_of: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 relationship: develops_from CL:0000134 ! mesenchymal cell relationship: has_plasma_membrane_part PR:000001444 ! cadherin-5 relationship: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 relationship: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 [Term] id: CL:0000567 name: polymodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: APUD cell namespace: cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544, MESH:A11.070] synonym: "amine precursor uptake and decarboxylation cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell namespace: cell def: "A mesenchymal cell found in the developing heart." [PMID:18816864] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000948 ! heart relationship: develops_from CL:0000011 ! migratory trunk neural crest cell relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0000570 name: parafollicular cell namespace: cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." [GOC:tfm, ISBN:0517223651] synonym: "C cell" EXACT [] synonym: "C cell of thyroid gland" EXACT [FMA:68653] synonym: "clear cell of thyroid gland" EXACT [FMA:68653] synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653] synonym: "thyroid parafollicular cell" EXACT [FMA:68653] xref: FMA:68653 xref: SCTID:176770005 is_a: CL:0000443 {is_inferred="true"} ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002215 GO:0001820 ! capable_of serotonin secretion intersection_of: RO:0002215 GO:0014046 ! capable_of dopamine secretion intersection_of: RO:0002215 GO:0036161 ! capable_of calcitonin secretion relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland relationship: RO:0002215 GO:0001820 ! capable_of serotonin secretion relationship: RO:0002215 GO:0014046 ! capable_of dopamine secretion relationship: RO:0002215 GO:0036161 ! capable_of calcitonin secretion [Term] id: CL:0000571 name: leucophore namespace: cell def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005003 ! leucoblast [Term] id: CL:0000573 name: retinal cone cell namespace: cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A08.663.650.650.670.100] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000574 name: erythrophore namespace: cell def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005004 ! pigment erythroblast [Term] id: CL:0000575 name: corneal epithelial cell namespace: cell alt_id: CL:1000431 def: "An epithelial cell of the cornea." [GOC:tfm] synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: CL:0000576 name: monocyte namespace: cell def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:A11.118.637.555.652] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: lacks_part GO:0030141 ! secretory granule intersection_of: RO:0002215 GO:0030225 ! capable_of macrophage differentiation intersection_of: RO:0002215 GO:0030316 ! capable_of osteoclast differentiation intersection_of: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation relationship: develops_from CL:0000559 ! promonocyte relationship: lacks_part GO:0030141 ! secretory granule relationship: RO:0002215 GO:0030225 ! capable_of macrophage differentiation relationship: RO:0002215 GO:0030316 ! capable_of osteoclast differentiation relationship: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation [Term] id: CL:0000577 name: type EC enteroendocrine cell namespace: cell alt_id: CL:0002065 def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [MESH:A03.492.766.440.250, PMID:9505449] synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 xref: FMA:83132 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0002251 ! epithelial cell of alimentary canal relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa [Term] id: CL:0000578 name: experimentally modified cell in vitro namespace: cell def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." [FB:ma, ReO:mhb] comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12 is_a: CL:0001034 ! cell in vitro [Term] id: CL:0000579 name: border follicle cell namespace: cell xref: FBbt:00004905 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000580 name: neutrophilic myelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. xref: BTO:0003455 xref: FMA:83540 is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: has_part PR:000009978 ! lactotransferrin intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part GO:0042582 ! azurophil granule relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000581 name: peritoneal macrophage namespace: cell def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:A11.329.372.630, PMID:15771589, PMID:19201820] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: BTO:0001034 xref: FMA:83025 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: located_in UBERON:0001179 ! peritoneal cavity intersection_of: RO:0002215 GO:0042742 ! capable_of defense response to bacterium relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: located_in UBERON:0001179 ! peritoneal cavity relationship: RO:0002215 GO:0042742 ! capable_of defense response to bacterium [Term] id: CL:0000582 name: neutrophilic metamyelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: has_part PR:000009978 ! lactotransferrin intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor relationship: develops_from CL:0000580 ! neutrophilic myelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor [Term] id: CL:0000583 name: alveolar macrophage namespace: cell def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:A11.329.372.600] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] xref: BTO:0000802 xref: CALOHA:TS-0030 xref: FMA:83023 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:1001603 ! lung macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: part_of UBERON:0002299 ! alveolus of lung intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: part_of UBERON:0002299 ! alveolus of lung relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation [Term] id: CL:0000584 name: enterocyte namespace: cell def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl] xref: BTO:0000398 xref: FMA:62122 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell [Term] id: CL:0000585 name: obsolete null cell namespace: cell def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." [] comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. is_obsolete: true [Term] id: CL:0000586 name: germ cell namespace: cell def: "The reproductive cell in multicellular organisms." [MESH:A05.360.490] xref: BTO:0000535 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell relationship: RO:0002215 GO:0048609 ! capable_of multicellular organismal reproductive process [Term] id: CL:0000587 name: cold sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast namespace: cell def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A11.329.679] xref: BTO:0002516 xref: FMA:83027 is_a: CL:0000092 {is_inferred="true"} ! osteoclast intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0002215 GO:0042483 ! capable_of negative regulation of odontogenesis relationship: RO:0002215 GO:0042483 ! capable_of negative regulation of odontogenesis [Term] id: CL:0000589 name: cochlear inner hair cell namespace: cell def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A08.663.650.250.250] synonym: "inner hair cell" BROAD [] xref: BTO:0003667 xref: FMA:62365 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000590 name: small luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400] synonym: "small lutein cell" EXACT [] synonym: "theca lutein cell" EXACT [] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000175 ! luteal cell relationship: develops_from CL:0000503 ! theca cell [Term] id: CL:0000591 name: warmth sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000592 name: large luteal cell namespace: cell def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400] synonym: "granulosa lutein cell" EXACT [] synonym: "granulosoluteocytus" RELATED [] xref: FMA:18689 is_a: CL:0000175 ! luteal cell is_a: CL:0000177 ! testosterone secreting cell relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000593 name: androgen secreting cell namespace: cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 ! capable_of androgen secretion relationship: RO:0002215 GO:0035935 ! capable_of androgen secretion [Term] id: CL:0000594 name: skeletal muscle satellite cell namespace: cell def: "An elongated, spindle-shaped, quiescent myoblast that are located between the basal lamina and the plasmalemma of the muscle fibres. They are thought to play a role in muscle repair and regeneration." [GOC:tfm, MESH:A11.635.500.700] is_a: CL:0000035 ! single fate stem cell is_a: CL:0000188 ! skeletal muscle cell is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000595 name: enucleate erythrocyte namespace: cell def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 {is_inferred="true"} ! erythrocyte intersection_of: CL:0000232 ! erythrocyte intersection_of: bearer_of PATO:0001405 ! anucleate relationship: bearer_of PATO:0001405 ! anucleate relationship: develops_from CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000596 name: sexual spore namespace: cell def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000597 name: microconidium namespace: cell def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [GOC:tfm, ISBN:0471940526, PMID:8357339, SGD:clt] xref: FAO:0000028 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0000598 name: pyramidal cell namespace: cell def: "A projection neuron in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region." [GOC:tfm, MESH:A08.186.211.577.405.700] synonym: "projection neuron" EXACT [] synonym: "pyramidal neuron" EXACT [] xref: BTO:0003102 xref: FMA:67310 xref: FMA:86775 xref: NIF_Cell:sao862606388 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000599 name: conidium namespace: cell def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [ISBN:08199377X, PMID:2524423, PMID:9529886, SGD:clt] xref: BTO:0000283 xref: FAO:0000024 is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000600 name: heterokaryon namespace: cell def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000521 ! fungal cell [Term] id: CL:0000601 name: outer hair cell namespace: cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A08.663.650.250.315] synonym: "cochlear outer hair cell" EXACT [] xref: BTO:0003666 xref: FMA:62366 is_a: CL:0000202 ! auditory hair cell relationship: part_of UBERON:0002227 ! spiral organ of cochlea [Term] id: CL:0000602 name: pressoreceptor cell namespace: cell def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A08.800.050.800.900.700] is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000603 name: dikaryon namespace: cell def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X] is_a: CL:0000227 ! binucleate cell is_a: CL:0000600 ! heterokaryon [Term] id: CL:0000604 name: retinal rod cell namespace: cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A08.663.650.650.670.650] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000605 name: fungal asexual spore namespace: cell def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium namespace: cell def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [GOC:tfm, ISBN:0471940526, SGD:clt] xref: FAO:0000038 is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore namespace: cell def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [GOC:tfm, ISBN:08199377X, SGD:clt] xref: BTO:0000097 xref: FAO:0000020 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore namespace: cell def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [ISBN:0471940526, ISBN:08199377X, SGD:clt] xref: FAO:0000040 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell namespace: cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:A08.663.650.250.380] synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! ear hair cell [Term] id: CL:0000610 name: obsolete plant cell namespace: cell comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO) is_obsolete: true consider: PO:0009002 [Term] id: CL:0000611 name: eosinophil progenitor cell namespace: cell comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). synonym: "CFU-Eo" RELATED [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" EXACT [PMCID:PMC2212039, PMCID:PMC2626675] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation [Term] id: CL:0000612 name: eosinophilic myelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [GOC:add, GOC:dsd, http://www.cap.org, ISBN:0721601464, PMID:19622087] xref: BTO:0003454 xref: FMA:83542 is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000613 name: basophil progenitor cell namespace: cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1312421] comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation [Term] id: CL:0000614 name: basophilic myelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030] xref: BTO:0003456 xref: FMA:83543 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000768 ! immature basophil intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0005730 ! nucleolus intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0005730 ! nucleolus relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000615 name: basidiospore namespace: cell def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [GOC:clt, ISBN:0471940526, ISBN:08199377X] xref: BTO:0002166 xref: FAO:0000021 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000616 name: obsolete sporangiospore namespace: cell def: "OBSOLETE: A walled spore produced in a sporangium." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000617 name: GABAergic neuron namespace: cell def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 xref: WBbt:0005190 is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable_of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0002215 GO:0061534 ! capable_of gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0000618 name: sheath cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000619 name: support cell (sensu Nematoda) namespace: cell is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia) is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000620 name: obsolete zoospore namespace: cell def: "OBSOLETE: A sporangiospore that is motile, having flagella." [ISBN:08199377X] xref: FAO:0000039 is_obsolete: true [Term] id: CL:0000621 name: fusion competent myoblast namespace: cell def: "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." [PMID:22274696] is_a: CL:0000056 ! myoblast relationship: RO:0002203 CL:0008003 ! develops into somatic muscle myotube [Term] id: CL:0000622 name: acinar cell namespace: cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell relationship: part_of UBERON:0009842 ! acinus [Term] id: CL:0000623 name: natural killer cell namespace: cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: BTO:0000914 xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 xref: VHOG:0001697 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: RO:0002215 GO:0002228 ! capable_of natural killer cell mediated immunity intersection_of: RO:0002215 GO:0050776 ! capable_of regulation of immune response relationship: develops_from CL:0000825 ! pro-NK cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: RO:0002215 GO:0002228 ! capable_of natural killer cell mediated immunity relationship: RO:0002215 GO:0050776 ! capable_of regulation of immune response [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell namespace: cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell namespace: cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000626 name: olfactory granule cell namespace: cell def: "Granule cell that is part of the olfactory bulb." [GOC:mah] is_a: CL:0000120 ! granule cell is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0002264 ! olfactory bulb [Term] id: CL:0000627 name: transporting cell namespace: cell def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr] is_a: CL:0000003 ! native cell [Term] id: CL:0000628 name: photosynthetic cell namespace: cell def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr] comment: see PMID:21177950, The making of a photosynthetic animal. is_a: CL:0000003 ! native cell [Term] id: CL:0000629 name: storage cell namespace: cell def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000630 name: supportive cell namespace: cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] xref: BTO:0002315 xref: FMA:86947 xref: ZFA:0000688 is_a: CL:0000003 ! native cell [Term] id: CL:0000631 name: labyrinth supporting cell namespace: cell def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:A09.246.631.246.577.543] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000632 name: hepatic stellate cell namespace: cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. synonym: "fat-storing cell" RELATED [] synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "Ito cell" EXACT [] synonym: "lipocyte" RELATED [] synonym: "perisinusoidal cell" EXACT [] synonym: "vitamin A-storing cells" RELATED [PMID:12808230] xref: BTO:0002741 xref: CALOHA:TS-0452 xref: FMA:67763 is_a: CL:0000057 ! fibroblast is_a: CL:0000327 ! extracellular matrix secreting cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein intersection_of: part_of UBERON:0002107 ! liver relationship: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000633 name: Hensen cell namespace: cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Hensen" EXACT [] synonym: "external limiting cell of organ of Corti" EXACT [] synonym: "Hensen's cell" EXACT [] xref: FMA:79799 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:0000634 name: Claudius cell namespace: cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Claudius" EXACT [] synonym: "external supporting cell of Claudius" EXACT [] synonym: "external supporting cell of vestibular epithelium" EXACT [] xref: FMA:79802 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell namespace: cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544] synonym: "Deiters cell" EXACT [] synonym: "outer phalangeal cell" EXACT [] xref: FMA:75725 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0000636 name: Mueller cell namespace: cell xref: BTO:0003064 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland namespace: cell def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256] xref: FMA:83089 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002196 ! adenohypophysis relationship: part_of UBERON:0002196 ! adenohypophysis relationship: RO:0002215 GO:0030072 ! capable_of peptide hormone secretion [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis namespace: cell def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis namespace: cell def: "A basophillic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] synonym: "pituitary beta cell" RELATED [] xref: FMA:83094 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000641 name: chromophobe cell namespace: cell def: "A cell that is resistant to stains." [GOC:tfm] synonym: "chromophobic cell" EXACT [] xref: FMA:83626 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000642 name: folliculostellate cell namespace: cell def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb] is_a: CL:0000163 ! endocrine cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000644 name: Bergmann glial cell namespace: cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000645 name: pituicyte namespace: cell def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651] xref: BTO:0003793 xref: FMA:83503 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000646 name: basal cell namespace: cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, ISBN:0517223651] xref: BTO:0000939 xref: FMA:62516 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000647 name: multinucleated giant cell namespace: cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:0702024783] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] xref: BTO:0003107 xref: FMA:83035 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: participates_in GO:0002432 ! granuloma formation intersection_of: participates_in GO:0002544 ! chronic inflammatory response relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000235 ! macrophage relationship: participates_in GO:0002432 ! granuloma formation relationship: participates_in GO:0002544 ! chronic inflammatory response [Term] id: CL:0000648 name: kidney granular cell namespace: cell alt_id: CL:0000461 def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727] synonym: "JG cell" EXACT [] synonym: "juxtaglomerular cell" BROAD [] synonym: "renin secreting cell" EXACT [] xref: FMA:84138 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000618 ! juxtaglomerular complex cell [Term] id: CL:0000649 name: prickle cell namespace: cell alt_id: CL:0002186 def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." [GOC:tfm, ISBN:0721662544, ISBN:0815332181] synonym: "prickle cell of epidermis" EXACT [] xref: FMA:69059 is_a: CL:0000312 ! keratinocyte [Term] id: CL:0000650 name: mesangial cell namespace: cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells] xref: BTO:0000853 xref: CALOHA:TS-0617 xref: FMA:70972 is_a: CL:0000669 ! pericyte cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000651 name: mucous neck cell namespace: cell def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm] synonym: "neck cell" BROAD [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion [Term] id: CL:0000652 name: pinealocyte namespace: cell def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276] xref: BTO:0001068 xref: FMA:83417 is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000653 name: glomerular visceral epithelial cell namespace: cell def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:tfm] comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967] synonym: "glomerular podocyte" EXACT [FMA:70967] synonym: "podocyte" EXACT [] xref: BTO:0002295 is_a: CL:0002522 ! renal filtration cell is_a: CL:1000451 ! epithelial cell of visceral layer of glomerular capsule relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule [Term] id: CL:0000654 name: primary oocyte namespace: cell def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544] synonym: "primary oogonium" RELATED [] xref: BTO:0000512 xref: FMA:18645 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007126 ! meiosis relationship: develops_from CL:0000024 ! oogonial cell relationship: has_not_completed GO:0007126 ! meiosis [Term] id: CL:0000655 name: secondary oocyte namespace: cell def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544] synonym: "primary oogonium" RELATED [] xref: BTO:0003094 xref: FMA:18646 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007147 ! female meiosis II relationship: develops_from CL:0000654 ! primary oocyte relationship: has_not_completed GO:0007147 ! female meiosis II [Term] id: CL:0000656 name: primary spermatocyte namespace: cell def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544] xref: BTO:0001115 xref: CALOHA:TS-2194 xref: FMA:72292 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte intersection_of: CL:0000017 ! spermatocyte intersection_of: bearer_of PATO:0001394 ! diploid intersection_of: RO:0002215 GO:0007140 ! capable_of male meiosis relationship: bearer_of PATO:0001394 ! diploid relationship: RO:0002215 GO:0007140 ! capable_of male meiosis [Term] id: CL:0000657 name: secondary spermatocyte namespace: cell def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544] xref: BTO:0000709 xref: CALOHA:TS-2195 xref: FBbt:00004941 xref: FMA:72293 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte is_a: CL:0000413 ! haploid cell intersection_of: CL:0000017 ! spermatocyte intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0007142 ! capable_of male meiosis II relationship: bearer_of PATO:0001375 ! haploid relationship: develops_from CL:0000656 ! primary spermatocyte relationship: RO:0002215 GO:0007142 ! capable_of male meiosis II [Term] id: CL:0000658 name: cuticle secreting cell namespace: cell def: "An epithelial cell that secretes cuticle." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000659 name: eggshell secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes eggshell." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000500 ! follicular epithelial cell [Term] id: CL:0000660 name: glycocalyx secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes glycocalyx." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000662 name: neuroglioblast (sensu Nematoda) namespace: cell is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000663 name: valve cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000664 name: closable valve cell namespace: cell is_a: CL:0000185 ! myoepithelial cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000665 name: permanently open valve cell namespace: cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000666 name: fenestrated cell namespace: cell synonym: "window cell" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000667 name: collagen secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000668 name: obsolete parenchymal cell namespace: cell def: "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [ISBN:0471245208] comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. xref: BTO:0002174 xref: FMA:84638 is_obsolete: true [Term] id: CL:0000669 name: pericyte cell namespace: cell alt_id: CL:0000184 def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907] comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. synonym: "adventitial cell" RELATED [] synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [PMID:17986482] synonym: "cell of Rouget" EXACT [] synonym: "pericyte" EXACT [] synonym: "pericyte of Rouget" EXACT [] xref: BTO:0002441 xref: FMA:63174 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000670 name: primordial germ cell namespace: cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 {is_inferred="true"} ! germ line cell is_a: CL:0000219 {is_inferred="true"} ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: part_of UBERON:0000922 ! embryo intersection_of: RO:0002215 GO:0048870 ! capable_of cell motility relationship: part_of UBERON:0000922 ! embryo relationship: RO:0002215 GO:0048870 ! capable_of cell motility [Term] id: CL:0000671 name: centripetally migrating follicle cell namespace: cell xref: FBbt:00004906 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000672 name: obsolete tracheary element namespace: cell def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." [ISBN:0471245208] comment: replaced_by: PO:0000290 is_obsolete: true [Term] id: CL:0000673 name: Kenyon cell namespace: cell is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia) [Term] id: CL:0000674 name: interfollicle cell namespace: cell synonym: "fly stalk cell" EXACT [] xref: FBbt:00004910 is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000675 name: female gamete namespace: cell def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000676 name: cap cell namespace: cell xref: BTO:0001033 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000677 name: gut absorptive cell namespace: cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb] is_a: CL:0000212 ! absorptive cell [Term] id: CL:0000678 name: commissural neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000679 name: glutamatergic neuron namespace: cell xref: WBbt:0006829 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061535 ! capable_of glutamate secretion, neurotransmission relationship: RO:0002215 GO:0061535 ! capable_of glutamate secretion, neurotransmission [Term] id: CL:0000680 name: muscle precursor cell namespace: cell is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell intersection_of: GO:0005623 ! cell intersection_of: RO:0002203 CL:0000187 ! develops into muscle cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: RO:0002203 CL:0000187 ! develops into muscle cell [Term] id: CL:0000681 name: radial glial cell namespace: cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life. synonym: "forebrain radial glial cell" NARROW [] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000682 name: M cell of gut namespace: cell def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [GOC:jb, GOC:tfm] comment: Should double check and see if M cells are particular to a specific region. synonym: "M cell" BROAD [] synonym: "M-cell" EXACT [] synonym: "microfold cell" EXACT [] xref: BTO:0003600 xref: FMA:62929 is_a: CL:0000473 ! defensive cell is_a: CL:0000627 ! transporting cell is_a: CL:0002251 ! epithelial cell of alimentary canal relationship: part_of UBERON:0003929 ! gut epithelium [Term] id: CL:0000683 name: ependymoglial cell namespace: cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [http://neurolex.org/wiki/Category\:Ependymoglial_Cell, JB:jb] synonym: "ependymal astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000684 name: littoral cell of liver namespace: cell is_a: CL:0000077 ! mesothelial cell is_a: CL:0000182 ! hepatocyte relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000685 name: obsolete meristematic cell namespace: cell def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010] comment: replaced_by: PO:0004010 is_obsolete: true [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell namespace: cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0033326 ! capable_of cerebrospinal fluid secretion relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: RO:0002215 GO:0033326 ! capable_of cerebrospinal fluid secretion [Term] id: CL:0000687 name: R1 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000688 name: perijunctional fibroblast namespace: cell def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb] is_a: CL:0000057 ! fibroblast is_a: CL:0000630 ! supportive cell [Term] id: CL:0000689 name: myoendocrine cell namespace: cell def: "A cell with both myofibrils and secretory granules." [JB:jb] is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000690 name: R2 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000691 name: stellate interneuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000692 name: terminal Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb, PMID:16136171] synonym: "Schwann cell" BROAD [] is_a: CL:0000630 ! supportive cell is_a: CL:0002376 ! non-myelinating Schwann cell [Term] id: CL:0000693 name: neuroglioform cell namespace: cell def: "A stellate interneuron having 7-10 dendrites that may branch." [JB:jb] synonym: "spiderweb cell" EXACT [] is_a: CL:0000691 ! stellate interneuron [Term] id: CL:0000694 name: R3 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000695 name: Cajal-Retzius cell namespace: cell def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000696 name: PP cell namespace: cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000697 name: R4 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000698 name: obsolete paraganglial cell namespace: cell is_obsolete: true [Term] id: CL:0000699 name: paraganglial type 1 cell namespace: cell def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." [GOC:tfm] is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000700 name: dopaminergic neuron namespace: cell def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill] synonym: "dopaminergic cell" EXACT [] xref: BTO:0004032 xref: FMA:84787 xref: WBbt:0006746 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061527 ! capable_of dopamine secretion, neurotransmission relationship: RO:0002215 GO:0061527 ! capable_of dopamine secretion, neurotransmission [Term] id: CL:0000701 name: paraganglia type 2 cell namespace: cell def: "Supports paraganglial type 1 cell." [JB:jb] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000702 name: R5 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000703 name: sustentacular cell namespace: cell def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb] xref: BTO:0002315 is_a: CL:0000630 ! supportive cell [Term] id: CL:0000704 name: endothelial tip cell namespace: cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0000705 name: R6 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000706 name: choroid plexus epithelial cell namespace: cell alt_id: CL:1000430 def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000627 ! transporting cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000065 ! ependymal cell intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus [Term] id: CL:0000707 name: R7 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000494 ! UV sensitive photoreceptor cell [Term] id: CL:0000708 name: leptomeningeal cell namespace: cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb] synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier [Term] id: CL:0000709 name: R8 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000710 name: neurecto-epithelial cell namespace: cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000711 name: cumulus cell namespace: cell def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [GOC:tfm, http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells] xref: BTO:0002236 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002174 ! follicular cell of ovary relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000712 name: stratum granulosum cell namespace: cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000362 ! epidermal cell intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis relationship: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis [Term] id: CL:0000713 name: corona radiata cell namespace: cell is_a: CL:0000711 ! cumulus cell [Term] id: CL:0000715 name: embryonic crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000717 name: fusimotor neuron namespace: cell def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000718 name: cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000306 ! crystallin accumulating cell [Term] id: CL:0000719 name: posterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000720 name: anterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000721 name: equatorial cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000722 name: cystoblast namespace: cell is_a: CL:0000586 ! germ cell [Term] id: CL:0000723 name: somatic stem cell namespace: cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 ! capable_of somatic stem cell division relationship: RO:0002215 GO:0048103 ! capable_of somatic stem cell division [Term] id: CL:0000724 name: heterocyst namespace: cell def: " A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma] xref: BTO:0000600 is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000726 name: chlamydospore namespace: cell def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [GOC:tfm, ISBN:085199377X] comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000727 name: primary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000728 name: secondary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000729 name: tertiary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000730 name: leading edge cell namespace: cell def: "A cell at the front of a migrating epithelial sheet." [MA:ma] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000731 name: urothelial cell namespace: cell def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [GOC:tfm, MA:ma] synonym: "bladder transitional cell" NARROW [] synonym: "transitional epithelial cell of urinary bladder" NARROW [] synonym: "urinary tract transitional epithelial cell" NARROW [] xref: FMA:84127 is_a: CL:0000244 {is_inferred="true"} ! transitional epithelial cell intersection_of: CL:0000244 ! transitional epithelial cell intersection_of: part_of UBERON:0000365 ! urothelium relationship: part_of UBERON:0000365 ! urothelium [Term] id: CL:0000732 name: amoeboid cell namespace: cell is_a: CL:0000219 ! motile cell [Term] id: CL:0000733 name: lymph gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000734 name: embryonic gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000735 name: lymph gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000736 name: embryonic gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000737 name: striated muscle cell namespace: cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001410 ! striated intersection_of: has_part GO:0030017 ! sarcomere disjoint_from: CL:0008000 ! non-striated muscle cell relationship: bearer_of PATO:0001410 ! striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000738 name: leukocyte namespace: cell def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] synonym: "immune cell" EXACT [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 is_a: CL:0000219 ! motile cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0001667 ! capable_of ameboidal cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: part_of UBERON:0002405 ! immune system relationship: RO:0002215 GO:0001667 ! capable_of ameboidal cell migration [Term] id: CL:0000740 name: retinal ganglion cell namespace: cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" EXACT [] xref: BTO:0001800 xref: FMA:67765 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000741 name: spinal accessory motor neuron namespace: cell def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219] synonym: "SACMN" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000742 name: periarticular chondrocyte namespace: cell def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842] is_a: CL:1001607 ! articular chondrocyte relationship: part_of UBERON:0010996 ! articular cartilage of joint [Term] id: CL:0000743 name: hypertrophic chondrocyte namespace: cell def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [GO_REF:0000034, PMID:15951842] comment: is hypertrophic pathological or normal? and can it be described using a pato term? is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000744 name: columnar chondrocyte namespace: cell def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000745 name: horizontal cell namespace: cell def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433] xref: BTO:0004120 is_a: CL:0000099 ! interneuron [Term] id: CL:0000746 name: cardiac muscle cell namespace: cell alt_id: FMA:83808 def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0007100 ! circulatory organ intersection_of: participates_in GO:0060047 ! heart contraction relationship: bearer_of PATO:0002478 ! transversely striated relationship: develops_from CL:0000513 ! cardiac muscle myoblast relationship: has_part GO:0030017 ! sarcomere relationship: part_of UBERON:0007100 ! circulatory organ relationship: participates_in GO:0060047 ! heart contraction [Term] id: CL:0000747 name: cyanophore namespace: cell def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl] synonym: "blue chromatophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005005 ! cyanoblast [Term] id: CL:0000748 name: retinal bipolar neuron namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000103 ! bipolar neuron is_a: CL:0009004 ! retinal cell relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0000749 name: ON-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000750 name: OFF-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000751 name: rod bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [GOC:tfm, PMID:14689473] xref: FMA:67750 is_a: CL:0000749 ! ON-bipolar cell [Term] id: CL:0000752 name: cone retinal bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000753 name: type 1 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473] synonym: "DB1 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000754 name: type 2 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1." [PMID:14689473] synonym: "FMB cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000755 name: type 3 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB2 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000756 name: type 4 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB3 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000757 name: type 5 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473] synonym: "DB4 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000758 name: type 6 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473] synonym: "DB5 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000759 name: type 7 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473] synonym: "IMB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000760 name: type 8 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473] synonym: "DB6 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000761 name: type 9 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473] synonym: "BB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000762 name: nucleated thrombocyte namespace: cell def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205] comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: RO:0002215 GO:0007596 ! capable_of blood coagulation relationship: bearer_of PATO:0001407 ! mononucleate relationship: develops_from CL:0000828 ! thromboblast relationship: RO:0002215 GO:0007596 ! capable_of blood coagulation [Term] id: CL:0000763 name: myeloid cell namespace: cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] xref: BTO:0001441 xref: CALOHA:TS-0647 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell namespace: cell alt_id: CL:0002156 def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell [Term] id: CL:0000765 name: erythroblast namespace: cell def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_part GO:0005634 ! nucleus intersection_of: lacks_part GO:0005730 ! nucleolus intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part GO:0005634 ! nucleus relationship: lacks_part GO:0005730 ! nucleolus relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation [Term] id: CL:0000766 name: myeloid leukocyte namespace: cell def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] is_a: CL:0000738 {is_inferred="true"} ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000129 xref: CALOHA:TS-0073 xref: FMA:62862 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_high_plasma_membrane_amount PR:000001255 ! chemokine receptor CCR3 intersection_of: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 intersection_of: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5 relationship: has_high_plasma_membrane_amount PR:000001255 ! chemokine receptor CCR3 relationship: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 relationship: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5 [Term] id: CL:0000768 name: immature basophil namespace: cell def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000767 ! basophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus [Term] id: CL:0000769 name: basophilic metamyelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [GOC:tfm, ISBN:0721601464, PMID:18466030] xref: FMA:84198 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: develops_from CL:0000614 ! basophilic myelocyte relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N [Term] id: CL:0000770 name: band form basophil namespace: cell def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, http://www.cap.org, ISBN:0721601464, PMID:18466030] is_a: CL:0000768 {is_inferred="true"} ! immature basophil intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000039 ! banded nucleus relationship: develops_from CL:0000769 ! basophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus [Term] id: CL:0000771 name: eosinophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_plasma_membrane_part PR:000001254 ! chemokine receptor CCR1 intersection_of: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000001254 ! chemokine receptor CCR1 relationship: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule [Term] id: CL:0000772 name: immature eosinophil namespace: cell def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000771 ! eosinophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus relationship: develops_from CL:0000833 ! eosinophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus [Term] id: CL:0000773 name: eosinophilic metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: develops_from CL:0000612 ! eosinophilic myelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N [Term] id: CL:0000774 name: band form eosinophil namespace: cell def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000039 ! banded nucleus relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus [Term] id: CL:0000775 name: neutrophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000776 name: immature neutrophil namespace: cell def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 {is_inferred="true"} ! neutrophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000775 ! neutrophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus [Term] id: CL:0000777 name: mesangial phagocyte namespace: cell def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:0002681 ! kidney cortical cell is_a: CL:1000500 ! kidney interstitial cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0002320 ! glomerular mesangium intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation intersection_of: RO:0002215 GO:0048771 ! capable_of tissue remodeling relationship: part_of UBERON:0002320 ! glomerular mesangium relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: RO:0002215 GO:0048771 ! capable_of tissue remodeling [Term] id: CL:0000778 name: mononuclear osteoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000226 ! single nucleate cell intersection_of: CL:0000092 ! osteoclast intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000779 name: multinuclear osteoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000092 ! osteoclast intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000781 ! mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000778 {is_inferred="true"} ! mononuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000782 name: myeloid dendritic cell namespace: cell def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: develops_from CL:0000763 ! myeloid cell intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0000576 ! monocyte relationship: develops_from CL:0000763 ! myeloid cell relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain [Term] id: CL:0000783 name: multinucleated phagocyte namespace: cell def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000784 name: plasmacytoid dendritic cell namespace: cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, GOC:dsd, PMCID:PMC2118448, PMCID:PMC538703, PMID:15549123, PMID:17332250, PMID:17850486, PMID:20304825] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] xref: BTO:0004625 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0002215 GO:0032606 ! capable_of type I interferon production relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: RO:0002215 GO:0032606 ! capable_of type I interferon production [Term] id: CL:0000785 name: mature B cell namespace: cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, GOC:dsd, ISBN:0781735149] comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_completed GO:0002335 ! mature B cell differentiation intersection_of: RO:0002215 GO:0042113 ! capable_of B cell activation disjoint_from: CL:0000816 ! immature B cell disjoint_from: CL:0000817 ! precursor B cell disjoint_from: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_completed GO:0002335 ! mature B cell differentiation relationship: RO:0002215 GO:0002504 ! capable_of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002215 GO:0042113 ! capable_of B cell activation [Term] id: CL:0000786 name: plasma cell namespace: cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Plasma_cell, ISBN:0721601464, ISBN:0781735149, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20951740] comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell intersection_of: CL:0000946 ! antibody secreting cell intersection_of: has_part CP:0000043 ! cartwheel heterochromatin intersection_of: has_part GO:0005794 ! Golgi apparatus intersection_of: has_plasma_membrane_part PR:000001935 ! syndecan-1 intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: develops_from CL:0000980 ! plasmablast relationship: has_part CP:0000043 ! cartwheel heterochromatin relationship: has_part GO:0005794 ! Golgi apparatus relationship: has_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000787 name: memory B cell namespace: cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, http://en.wikipedia.org/wiki/Memory_B_cell, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_completed GO:0002344 ! B cell affinity maturation intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: has_completed GO:0002344 ! B cell affinity maturation relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 [Term] id: CL:0000788 name: naive B cell namespace: cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20933013, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_not_completed GO:0002344 ! B cell affinity maturation intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_not_completed GO:0002344 ! B cell affinity maturation relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule [Term] id: CL:0000789 name: alpha-beta T cell namespace: cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex disjoint_from: CL:0000798 ! gamma-delta T cell relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex [Term] id: CL:0000790 name: immature alpha-beta T cell namespace: cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000791 name: mature alpha-beta T cell namespace: cell def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000790 ! immature alpha-beta T cell relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" BROAD [PMID:22343568] xref: FMA:84070 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_low_plasma_membrane_amount PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: has_low_plasma_membrane_amount PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_part PR:000003466 ! perforin-1 intersection_of: has_part PR:000003499 ! granzyme B intersection_of: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity intersection_of: RO:0002215 GO:0033380 ! capable_of granzyme B localization to T cell secretory granule relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_part PR:000003466 ! perforin-1 relationship: has_part PR:000003499 ! granzyme B relationship: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity relationship: RO:0002215 GO:0033380 ! capable_of granzyme B localization to T cell secretory granule [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: FMA:84070 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell namespace: cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell namespace: cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response [Term] id: CL:0000798 name: gamma-delta T cell namespace: cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex [Term] id: CL:0000799 name: immature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_not_completed GO:0042492 ! gamma-delta T cell differentiation intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_not_completed GO:0042492 ! gamma-delta T cell differentiation relationship: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000800 name: mature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000799 ! immature gamma-delta T cell relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell namespace: cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000805 name: immature single positive thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000808 ! DN4 thymocyte relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000806 name: DN2 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000807 name: DN3 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000806 ! DN2 thymocyte relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000808 name: DN4 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte namespace: cell def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Thymocytes of this stage are undergoing positive and negative selection. synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000805 ! immature single positive thymocyte relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000813 name: memory T cell namespace: cell def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] xref: BTO:0003435 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha disjoint_from: CL:0000898 ! naive T cell relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000814 name: mature NK T cell namespace: cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: develops_from CL:0002042 ! immature NK T cell stage IV relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity relationship: RO:0002215 GO:0045087 ! capable_of innate immune response [Term] id: CL:0000815 name: regulatory T cell namespace: cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: BTO:0004520 xref: FMA:84070 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000816 name: immature B cell namespace: cell def: "An immature B cell is a precursor B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, GOC:tfm, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [ISBN:781735149] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000236 ! B cell intersection_of: has_not_completed GO:0045190 ! isotype switching intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: develops_from CL:0000954 ! small pre-B-II cell relationship: has_not_completed GO:0045190 ! isotype switching relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000817 name: precursor B cell namespace: cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm] synonym: "pre-B cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin disjoint_from: CL:0000826 ! pro-B cell relationship: has_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0000818 name: transitional stage B cell namespace: cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional B cell" EXACT [PMID:22343568] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_not_completed GO:0002335 ! mature B cell differentiation intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: develops_from CL:0000816 ! immature B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_not_completed GO:0002335 ! mature B cell differentiation relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000819 name: B-1 B cell namespace: cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/B-1_cell, PMID:11861604, PMID:20933013, PMID:21220451] comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: RO:0002215 GO:0045087 ! capable_of innate immune response [Term] id: CL:0000820 name: B-1a B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000821 name: B-1b B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000822 name: B-2 B cell namespace: cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:11861604, PMID:20933013] comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000823 name: immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000623 {is_inferred="true"} ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: bearer_of PATO:0001501 ! immature disjoint_from: CL:0000824 ! mature natural killer cell disjoint_from: CL:0000937 ! pre-natural killer cell relationship: bearer_of PATO:0001501 ! immature relationship: develops_from CL:0000937 ! pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell namespace: cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782] synonym: "LAK cell" BROAD [PMID:14685782] synonym: "lymphokine activated killer cell" BROAD [PMID:14685782] synonym: "mature NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: develops_from CL:0000823 ! immature natural killer cell [Term] id: CL:0000825 name: pro-NK cell namespace: cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674] comment: Most markers only described for human pro NK cells. synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674] synonym: "null cell" RELATED [PMID:11532393] synonym: "preNK cell" RELATED [PMID:11532393] synonym: "pro-natural killer cell" EXACT [] is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor [Term] id: CL:0000826 name: pro-B cell namespace: cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, GOC:dsd, ISBN:0781735149, PMID:12633665, PMID:16551251, PMID:18432934] comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] synonym: "pre-pro B cell" BROAD [PMID:17582343] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] synonym: "progenitor B lymphocyte" EXACT [] synonym: "progenitor B-cell" EXACT [] synonym: "progenitor B-lymphocyte" EXACT [] xref: BTO:0003104 is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: has_part PR:000001903 ! paired box protein PAX-5 intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: participates_in GO:0033152 ! immunoglobulin V(D)J recombination relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part PR:000001903 ! paired box protein PAX-5 relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase relationship: participates_in GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: CL:0000827 name: pro-T cell namespace: cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 ! capable_of T cell differentiation relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: RO:0002215 GO:0030217 ! capable_of T cell differentiation [Term] id: CL:0000828 name: thromboblast namespace: cell def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949] comment: Note that this is a non-mammalian cell type. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: RO:0002215 GO:0002574 ! capable_of thrombocyte differentiation relationship: bearer_of PATO:0001407 ! mononucleate relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0002574 ! capable_of thrombocyte differentiation [Term] id: CL:0000829 name: basophilic myeloblast namespace: cell def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: develops_from CL:0000613 ! basophil progenitor cell relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation [Term] id: CL:0000830 name: basophilic promyelocyte namespace: cell def: "A promyelocyte committed to the basophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84208 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: develops_from CL:0000829 ! basophilic myeloblast relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation [Term] id: CL:0000831 name: mast cell progenitor namespace: cell def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1183570, PMCID:PMC1312421, PMID:8629001, PMID:9354811] comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. synonym: "CFU-Mast " RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0060374 ! capable_of mast cell differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0060374 ! capable_of mast cell differentiation [Term] id: CL:0000832 name: eosinophilic myeloblast namespace: cell def: "A myeloblast committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation relationship: develops_from CL:0000611 ! eosinophil progenitor cell relationship: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation [Term] id: CL:0000833 name: eosinophilic promyelocyte namespace: cell def: "A promyelocyte committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84199 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation relationship: develops_from CL:0000832 ! eosinophilic myeloblast relationship: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation [Term] id: CL:0000834 name: neutrophil progenitor cell namespace: cell def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation [Term] id: CL:0000835 name: myeloblast namespace: cell def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] xref: BTO:0000187 xref: FMA:83524 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0000791 ! euchromatin intersection_of: lacks_part GO:0042582 ! azurophil granule relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0000791 ! euchromatin relationship: lacks_part GO:0042582 ! azurophil granule [Term] id: CL:0000836 name: promyelocyte namespace: cell def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [GOC:add, GOC:amm, GOC:tfm, http://www.cap.org, ISBN:0721601464] xref: CALOHA:TS-0825 xref: FMA:83530 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0000835 ! myeloblast relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0005730 ! nucleolus relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001402 ! multipotent intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: bearer_of PATO:0001402 ! multipotent relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "lymphoid progenitor cell" BROAD [] xref: BTO:0004731 xref: CALOHA:TS-2025 xref: FMA:70338 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 ! capable_of myeloid cell differentiation relationship: RO:0002215 GO:0030099 ! capable_of myeloid cell differentiation [Term] id: CL:0000840 name: immature conventional dendritic cell namespace: cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [GOC:add, GOC:tfm, PMID:9521319] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000841 name: mature conventional dendritic cell namespace: cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, GOC:tfm, PMID:9521319] synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000840 ! immature conventional dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000842 name: mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: lacks_part GO:0030141 ! secretory granule relationship: bearer_of PATO:0001407 ! mononucleate relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000843 name: follicular B cell namespace: cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Follicular_B_Cells, ISBN:0781735149, PMCID:PMC2193793, PMID:20933013] comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor [Term] id: CL:0000844 name: germinal center B cell namespace: cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: part_of UBERON:0001745 ! secondary nodular lymphoid tissue relationship: develops_from CL:0000843 ! follicular B cell relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue [Term] id: CL:0000845 name: marginal zone B cell namespace: cell def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Marginal-zone_B_cell, ISBN:0781735149, PMID:10933592, PMID:20933013] comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. synonym: "marginal zone B lymphocyte" EXACT [] synonym: "marginal zone B-cell" EXACT [] synonym: "marginal zone B-lymphocyte" EXACT [] synonym: "MZ B cell" EXACT [] synonym: "MZ B lymphocyte" EXACT [] synonym: "MZ B-cell" EXACT [] synonym: "MZ B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: part_of UBERON:0001251 ! marginal zone of spleen intersection_of: RO:0002215 GO:0042742 ! capable_of defense response to bacterium relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: part_of UBERON:0001251 ! marginal zone of spleen relationship: RO:0002215 GO:0042742 ! capable_of defense response to bacterium [Term] id: CL:0000846 name: vestibular dark cell namespace: cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000847 name: ciliated olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163] synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] is_a: CL:0000064 ! ciliated cell is_a: CL:0000207 ! olfactory receptor cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000848 name: microvillous olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163] synonym: "microvillous olfactory sensory neuron" EXACT [] synonym: "microvillous sensory neuron" RELATED [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000849 name: crypt olfactory receptor neuron namespace: cell def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163] synonym: "crypt cell" EXACT [] synonym: "crypt olfactory sensory neuron" EXACT [] synonym: "crypt sensory neuron" EXACT [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000850 name: serotonergic neuron namespace: cell alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: FBbt:00005133 xref: WBbt:0006837 is_a: CL:0000540 ! neuron [Term] id: CL:0000851 name: neuromast mantle cell namespace: cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509] is_a: CL:0000151 ! secretory cell is_a: CL:0002319 ! neural cell disjoint_from: CL:0000855 ! sensory hair cell relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000852 name: neuromast support cell namespace: cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509] is_a: CL:0000630 ! supportive cell is_a: CL:0002319 ! neural cell disjoint_from: CL:0000855 ! sensory hair cell relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000853 name: olfactory epithelial support cell namespace: cell def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl] synonym: "olfactory sustentacular cell" EXACT [] synonym: "supporting cell of olfactory epithelium" EXACT [] synonym: "sustentaculocyte of olfactory epithelium" EXACT [] xref: FMA:62302 is_a: CL:0000630 ! supportive cell is_a: CL:0002167 ! olfactory epithelial cell [Term] id: CL:0000854 name: interneuromast cell namespace: cell def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl] is_a: CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000032 ! neuroplacodal cell [Term] id: CL:0000855 name: sensory hair cell namespace: cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl] synonym: "hair cell" BROAD [] xref: BTO:0004744 is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell namespace: cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl] is_a: CL:0000855 ! sensory hair cell intersection_of: CL:0000855 ! sensory hair cell intersection_of: part_of UBERON:0008904 ! neuromast relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000857 name: slow muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000189 ! develops into slow muscle cell relationship: RO:0002203 CL:0000189 ! develops into slow muscle cell [Term] id: CL:0000858 name: fast muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000190 ! develops into fast muscle cell relationship: RO:0002203 CL:0000190 ! develops into fast muscle cell [Term] id: CL:0000860 name: classical monocyte namespace: cell def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000234 ! phagocyte is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0002548 ! capable_of monocyte chemotaxis intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0006954 ! capable_of inflammatory response relationship: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0002548 ! capable_of monocyte chemotaxis relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0006954 ! capable_of inflammatory response [Term] id: CL:0000861 name: elicited macrophage namespace: cell def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: participates_in GO:0006954 ! inflammatory response relationship: develops_from CL:0000860 ! classical monocyte relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: participates_in GO:0006954 ! inflammatory response [Term] id: CL:0000862 name: suppressor macrophage namespace: cell def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000863 name: inflammatory macrophage namespace: cell def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana, PMID:19132917] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0032611 ! capable_of interleukin-1 beta production intersection_of: RO:0002215 GO:0032635 ! capable_of interleukin-6 production intersection_of: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production intersection_of: RO:0002215 GO:0042554 ! capable_of superoxide anion generation intersection_of: RO:0002215 GO:0042742 ! capable_of defense response to bacterium intersection_of: RO:0002215 GO:0051767 ! capable_of nitric-oxide synthase biosynthetic process relationship: RO:0002215 GO:0032611 ! capable_of interleukin-1 beta production relationship: RO:0002215 GO:0032635 ! capable_of interleukin-6 production relationship: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production relationship: RO:0002215 GO:0042554 ! capable_of superoxide anion generation relationship: RO:0002215 GO:0042742 ! capable_of defense response to bacterium relationship: RO:0002215 GO:0051767 ! capable_of nitric-oxide synthase biosynthetic process [Term] id: CL:0000864 name: tissue-resident macrophage namespace: cell def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0000479 ! tissue relationship: part_of UBERON:0000479 ! tissue [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine relationship: part_of UBERON:0001238 ! lamina propria of small intestine [Term] id: CL:0000866 name: thymic macrophage namespace: cell def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0002370 ! thymus intersection_of: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance relationship: part_of UBERON:0002370 ! thymus relationship: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance [Term] id: CL:0000867 name: secondary lymphoid organ macrophage namespace: cell def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865] comment: Marker was observed on rat cells. synonym: "MF.LN" EXACT [] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0000029 ! lymph node relationship: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0000029 ! lymph node [Term] id: CL:0000869 name: tonsillar macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0002372 ! tonsil intersection_of: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue relationship: part_of UBERON:0002372 ! tonsil relationship: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue [Term] id: CL:0000870 name: Peyer's patch macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: CL:0000871 name: splenic macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: part_of UBERON:0002106 ! spleen intersection_of: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance relationship: part_of UBERON:0002106 ! spleen relationship: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance [Term] id: CL:0000872 name: splenic marginal zone macrophage namespace: cell def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO intersection_of: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: part_of UBERON:0001251 ! marginal zone of spleen relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO relationship: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000873 name: splenic metallophillic macrophage namespace: cell def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001251 ! marginal zone of spleen intersection_of: RO:0002220 UBERON:0001959 ! adjacent_to white pulp of spleen relationship: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001251 ! marginal zone of spleen relationship: RO:0002220 UBERON:0001959 ! adjacent_to white pulp of spleen [Term] id: CL:0000874 name: splenic red pulp macrophage namespace: cell def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: part_of UBERON:0001250 ! red pulp of spleen intersection_of: RO:0002215 GO:0006955 ! capable_of immune response intersection_of: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: part_of UBERON:0001250 ! red pulp of spleen relationship: RO:0002215 GO:0006955 ! capable_of immune response relationship: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance [Term] id: CL:0000875 name: non-classical monocyte namespace: cell def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: bearer_of PATO:0000587 ! decreased size intersection_of: has_completed GO:0030224 ! monocyte differentiation intersection_of: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0031294 ! capable_of lymphocyte costimulation relationship: bearer_of PATO:0000587 ! decreased size relationship: develops_from CL:0002393 ! intermediate monocyte relationship: has_completed GO:0030224 ! monocyte differentiation relationship: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0031294 ! capable_of lymphocyte costimulation [Term] id: CL:0000876 name: splenic white pulp macrophage namespace: cell def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597] comment: Markers: Mouse: F4/80-, CD68+, macrosialin+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001959 ! white pulp of spleen relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001959 ! white pulp of spleen [Term] id: CL:0000877 name: splenic tingible body macrophage namespace: cell def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000876 {is_inferred="true"} ! splenic white pulp macrophage intersection_of: CL:0000876 ! splenic white pulp macrophage intersection_of: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer intersection_of: part_of UBERON:0001249 ! spleen lymphoid follicle intersection_of: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance relationship: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer relationship: part_of UBERON:0001249 ! spleen lymphoid follicle relationship: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance [Term] id: CL:0000878 name: central nervous system macrophage namespace: cell def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:0002319 ! neural cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000879 name: meningeal macrophage namespace: cell def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:11591794] is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: part_of UBERON:0002360 ! meninx intersection_of: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity relationship: part_of UBERON:0002360 ! meninx relationship: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity [Term] id: CL:0000880 name: choroid-plexus macrophage namespace: cell def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:9550136] is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: located_in UBERON:0001886 ! choroid plexus intersection_of: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity relationship: located_in UBERON:0001886 ! choroid plexus relationship: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity [Term] id: CL:0000881 name: perivascular macrophage namespace: cell def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: part_of UBERON:0001981 ! blood vessel relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: part_of UBERON:0001981 ! blood vessel [Term] id: CL:0000882 name: thymic medullary macrophage namespace: cell def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana, PMID:9048205] is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus [Term] id: CL:0000883 name: thymic cortical macrophage namespace: cell def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage namespace: cell def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19906191] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana, PMID:19906191] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001962 ! gut-associated lymphoid tissue intersection_of: RO:0002215 GO:0002387 ! capable_of immune response in gut-associated lymphoid tissue relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue relationship: RO:0002215 GO:0002387 ! capable_of immune response in gut-associated lymphoid tissue [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue intersection_of: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue relationship: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage namespace: cell def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [GO_REF:0000031, GOC:tfm, PMID:14668803, PMID:17934446, PMID:20228797] is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: RO:0002215 GO:0032816 ! capable_of positive regulation of natural killer cell activation intersection_of: RO:0002220 UBERON:0002194 ! adjacent_to capsule of lymph node relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: RO:0002215 GO:0032816 ! capable_of positive regulation of natural killer cell activation relationship: RO:0002220 UBERON:0002194 ! adjacent_to capsule of lymph node [Term] id: CL:0000888 name: lymph node tingible body macrophage namespace: cell def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: part_of UBERON:0002006 ! cortex of lymph node intersection_of: RO:0002215 GO:0002905 ! capable_of regulation of mature B cell apoptotic process intersection_of: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance relationship: part_of UBERON:0002006 ! cortex of lymph node relationship: RO:0002215 GO:0002905 ! capable_of regulation of mature B cell apoptotic process relationship: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance [Term] id: CL:0000889 name: myeloid suppressor cell namespace: cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: bearer_of PATO:0001501 ! immature intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: bearer_of PATO:0001501 ! immature relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000890 name: alternatively activated macrophage namespace: cell def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:20510870] comment: Role or process: tissue remodeling. synonym: "M2 macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: has_part PR:000001844 ! arginase-1 intersection_of: RO:0002215 GO:0048771 ! capable_of tissue remodeling relationship: has_part PR:000001844 ! arginase-1 relationship: RO:0002215 GO:0048771 ! capable_of tissue remodeling [Term] id: CL:0000891 name: foam cell namespace: cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] xref: BTO:0003872 xref: FMA:83586 is_a: CL:0000003 ! native cell [Term] id: CL:0000892 name: smooth muscle cell derived foam cell namespace: cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000192 ! smooth muscle cell [Term] id: CL:0000893 name: thymocyte namespace: cell def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 xref: XAO:0003159 is_a: CL:0002420 {is_inferred="true"} ! immature T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 ! T cell selection intersection_of: part_of UBERON:0002370 ! thymus relationship: has_not_completed GO:0045058 ! T cell selection relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000894 name: DN1 thymic pro-T cell namespace: cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0002425 ! early T lineage precursor relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell namespace: cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699, PMID:22343568] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. synonym: "naive CD4+ T cell" BROAD [PMID:22343568] synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [GOC:tfm] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell namespace: cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000898 name: naive T cell namespace: cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_completed GO:0045058 ! T cell selection intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_completed GO:0045058 ! T cell selection relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000899 name: T-helper 17 cell namespace: cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875, PMID:20969597, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 CD4+ T cell" EXACT [PMID:22343568] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032620 ! capable_of interleukin-17 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032620 ! capable_of interleukin-17 production [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149, PMID:22343568] comment: This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. synonym: "naive CD8+ T cell" BROAD [PMID:22343568] synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000901 name: Tr1 cell namespace: cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam, PMID:16903904] comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000902 name: induced T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 [Term] id: CL:0000903 name: natural T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4+ T cell" BROAD [PMID:22343568] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4+ T cell" BROAD [PMID:22343568] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000907 name: central memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8+ T cell" BROAD [PMID:22343568] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000910 name: cytotoxic T cell namespace: cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: BTO:0000289 xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity relationship: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity [Term] id: CL:0000911 name: effector T cell namespace: cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_completed GO:0045058 ! T cell selection relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000912 name: helper T cell namespace: cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8+ T cell" BROAD [PMID:22343568] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000914 name: immature NK T cell namespace: cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_part PR:000003469 ! early growth response protein 2 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000003469 ! early growth response protein 2 [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell namespace: cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000916 name: dendritic epidermal T cell namespace: cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: part_of UBERON:0001003 ! epidermis intersection_of: RO:0002215 GO:0060054 ! capable_of positive regulation of epithelial cell proliferation involved in wound healing relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor relationship: part_of UBERON:0001003 ! epidermis relationship: RO:0002215 GO:0060054 ! capable_of positive regulation of epithelial cell proliferation involved in wound healing [Term] id: CL:0000917 name: Tc1 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568, PMID:9914231] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells. synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 CD8+ T cell" EXACT [PMID:22343568] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] xref: BTO:0004793 xref: BTO:0004888 xref: FMA:84793 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21 intersection_of: has_part PR:000003463 ! eomesodermin intersection_of: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: has_part PR:000001835 ! T-box transcription factor TBX21 relationship: has_part PR:000003463 ! eomesodermin relationship: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000918 name: Tc2 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:9914231] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell. synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] xref: BTO:0004794 xref: FMA:84794 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] synonym: "CD8+CD25+ T(reg)" EXACT [] synonym: "CD8+CD25+ T-cell" EXACT [] synonym: "CD8+CD25+ T-lymphocyte " EXACT [] synonym: "CD8+CD25+ Treg" EXACT [] synonym: "CD8-positive, CD25-positive Treg" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell namespace: cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD28- T cell" EXACT [] synonym: "CD8+CD28- T lymphocyte" EXACT [] synonym: "CD8+CD28- T(reg)" EXACT [] synonym: "CD8+CD28- T-cell" EXACT [] synonym: "CD8+CD28- T-lymphocyte " EXACT [] synonym: "CD8+CD28- Treg" EXACT [] synonym: "CD8-positive, CD28-negative T(reg)" EXACT [] synonym: "CD8-positive, CD28-negative Treg" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28 relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28 [Term] id: CL:0000921 name: type I NK T cell namespace: cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0043208 ! capable_of glycosphingolipid binding relationship: RO:0002215 GO:0043208 ! capable_of glycosphingolipid binding [Term] id: CL:0000922 name: type II NK T cell namespace: cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0002288 ! capable_of NK T cell activation involved in immune response relationship: RO:0002215 GO:0002288 ! capable_of NK T cell activation involved in immune response [Term] id: CL:0000923 name: CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18997862] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032616 ! capable_of interleukin-13 production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable_of interleukin-13 production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002369 ! capable_of T cell cytokine production relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002369 ! capable_of T cell cytokine production [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000931 name: activated type II NK T cell namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0002369 ! capable_of T cell cytokine production relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0002369 ! capable_of T cell cytokine production [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, PMID:17964217] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 namespace: cell def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18440213] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 [Term] id: CL:0000936 name: early lymphoid progenitor namespace: cell def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. synonym: "ELP" EXACT [] synonym: "GMLP" RELATED [PMID:18371378] synonym: "LMPP" EXACT [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation [Term] id: CL:0000937 name: pre-natural killer cell namespace: cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874] comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 {is_inferred="true"} ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor [Term] id: CL:0000938 name: CD16-negative, CD56-bright natural killer cell namespace: cell def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19796267, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. synonym: "CD16-CD56bright NK cell" EXACT [PMID:22343568] synonym: "CD16-negative, CD56-bright NK cell" EXACT [] synonym: "CD56-bright cytokine secreting natural killer cell" EXACT [] synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001319 ! SLAM family member 5 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production disjoint_from: CL:0000939 ! CD16-positive, CD56-dim natural killer cell relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001319 ! SLAM family member 5 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000939 name: CD16-positive, CD56-dim natural killer cell namespace: cell def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19796267, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types. synonym: "CD16+CD56+ NK cell" EXACT [PMID:22343568] synonym: "CD16-positive, CD56-dim NK cell" EXACT [] synonym: "CD16-positive, CD56-low natural killer cell" EXACT [] synonym: "CD16-positive, CD56-low NK cell" EXACT [] synonym: "CD16-positive, CD56-positive natural killer cell" EXACT [] synonym: "CD16-positive, CD56-positive NK cell" EXACT [] synonym: "cytotoxic CD56-dim natural killer cell" EXACT [] synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0042267 ! capable_of natural killer cell mediated cytotoxicity relationship: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0042267 ! capable_of natural killer cell mediated cytotoxicity [Term] id: CL:0000940 name: mucosal invariant T cell namespace: cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19416870] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: RO:0002215 GO:0002227 ! capable_of innate immune response in mucosa intersection_of: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity relationship: has_completed GO:0030217 ! T cell differentiation relationship: RO:0002215 GO:0002227 ! capable_of innate immune response in mucosa relationship: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity [Term] id: CL:0000941 name: thymic conventional dendritic cell namespace: cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629] comment: In the mouse this cell expresses CD8-alpha-alpha. is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell namespace: cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000943 name: Be1 Cell namespace: cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 1 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production intersection_of: RO:0002215 GO:0032623 ! capable_of interleukin-2 production intersection_of: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production intersection_of: RO:0002215 GO:0045627 ! capable_of positive regulation of T-helper 1 cell differentiation relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: RO:0002215 GO:0032623 ! capable_of interleukin-2 production relationship: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production relationship: RO:0002215 GO:0045627 ! capable_of positive regulation of T-helper 1 cell differentiation [Term] id: CL:0000944 name: Be2 cell namespace: cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 2 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0032623 ! capable_of interleukin-2 production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production intersection_of: RO:0002215 GO:0032635 ! capable_of interleukin-6 production intersection_of: RO:0002215 GO:0045630 ! capable_of positive regulation of T-helper 2 cell differentiation relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0032623 ! capable_of interleukin-2 production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: RO:0002215 GO:0032635 ! capable_of interleukin-6 production relationship: RO:0002215 GO:0045630 ! capable_of positive regulation of T-helper 2 cell differentiation [Term] id: CL:0000945 name: lymphocyte of B lineage namespace: cell def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: develops_from CL:0000826 ! pro-B cell relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon [Term] id: CL:0000946 name: antibody secreting cell namespace: cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149] is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: secretes GO:0042571 ! immunoglobulin complex, circulating relationship: secretes GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000947 name: IgE plasma cell namespace: cell def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071743 ! IgE immunoglobulin complex, circulating relationship: secretes GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000948 name: IgE memory B cell namespace: cell def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex relationship: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex [Term] id: CL:0000949 name: IgD plasmablast namespace: cell def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071739 ! IgD immunoglobulin complex, circulating relationship: secretes GO:0071739 ! IgD immunoglobulin complex, circulating [Term] id: CL:0000950 name: IgE plasmablast namespace: cell def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071743 ! IgE immunoglobulin complex, circulating relationship: secretes GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000951 name: IgE short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071743 ! IgE immunoglobulin complex, circulating relationship: secretes GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell namespace: cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell namespace: cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000954 name: small pre-B-II cell namespace: cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:9785673] comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination [Term] id: CL:0000955 name: pre-B-II cell namespace: cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:9785673] comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination intersection_of: lacks_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule disjoint_from: CL:0000956 ! pre-B-I cell relationship: develops_from CL:0000826 ! pro-B cell relationship: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: lacks_part PR:000006611 ! DNA nucleotidylexotransferase relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule [Term] id: CL:0000956 name: pre-B-I cell namespace: cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:20839338, PMID:9785673] comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: develops_from CL:0000826 ! pro-B cell relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination [Term] id: CL:0000957 name: large pre-B-II cell namespace: cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, PMID:16551251, PMID:18432934, PMID:9785673] comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "large pre-B cell" BROAD [PMID:11244048] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: participates_in GO:0046651 ! lymphocyte proliferation relationship: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: participates_in GO:0046651 ! lymphocyte proliferation [Term] id: CL:0000958 name: T1 B cell namespace: cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000959 name: T2 B cell namespace: cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: develops_from CL:0000958 ! T1 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin [Term] id: CL:0000960 name: T3 B cell namespace: cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121] synonym: "An1 B cell" EXACT [PMID:17174121] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: participates_in GO:0002515 ! B cell anergy relationship: develops_from CL:0000959 ! T2 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: participates_in GO:0002515 ! B cell anergy [Term] id: CL:0000961 name: Bm1 B cell namespace: cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591] comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell is_a: CL:0002056 ! Fraction F mature B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000962 name: Bm2 B cell namespace: cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591] comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: develops_from CL:0000961 ! Bm1 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000963 name: Bm3-delta B cell namespace: cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752] synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000965 ! Bm3 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000964 name: Bm2' B cell namespace: cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:17992590, PMID:18432934, PMID:8006591] comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2' B-lymphocyte" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B lymphocyte " EXACT [] synonym: "Bm2-prime B-cell " EXACT [] synonym: "Bm2-prime B-lymphocyte " EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002215 GO:0002634 ! capable_of regulation of germinal center formation relationship: develops_from CL:0000962 ! Bm2 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002215 GO:0002634 ! capable_of regulation of germinal center formation [Term] id: CL:0000965 name: Bm3 B cell namespace: cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591] comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [PMID:8006591] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: RO:0002215 GO:0016446 ! capable_of somatic hypermutation of immunoglobulin genes relationship: develops_from CL:0000964 ! Bm2' B cell relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: RO:0002215 GO:0016446 ! capable_of somatic hypermutation of immunoglobulin genes [Term] id: CL:0000966 name: Bm4 B cell namespace: cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591] comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [PMID:17992590] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase relationship: develops_from CL:0000963 ! Bm3-delta B cell relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase [Term] id: CL:0000967 name: Bm5 B cell namespace: cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:18432934, PMID:8006591] comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_completed GO:0002314 ! germinal center B cell differentiation intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: develops_from CL:0000966 ! Bm4 B cell relationship: has_completed GO:0002314 ! germinal center B cell differentiation relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000968 name: Be cell namespace: cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0043370 ! capable_of regulation of CD4-positive, alpha-beta T cell differentiation relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0043370 ! capable_of regulation of CD4-positive, alpha-beta T cell differentiation [Term] id: CL:0000969 name: regulatory B cell namespace: cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, MESH:D060151, PMID:11869683, PMID:18482568, PMID:20224569, PMID:20809522] comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. synonym: "B(reg)" EXACT [] synonym: "B10 cell" EXACT [] synonym: "Breg" EXACT [] synonym: "regulatory B lymphocyte" EXACT [] synonym: "regulatory B-cell" EXACT [] synonym: "regulatory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000002028 ! T-cell surface glycoprotein CD1d intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000002028 ! T-cell surface glycoprotein CD1d relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000970 name: unswitched memory B cell namespace: cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "IgD+ memory B cell" BROAD [PMID:22343568] synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: develops_from CL:0000980 ! plasmablast relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 [Term] id: CL:0000971 name: IgM memory B cell namespace: cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676] comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000972 name: class switched memory B cell namespace: cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:9295047] comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_completed GO:0045190 ! isotype switching intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000970 ! unswitched memory B cell relationship: has_completed GO:0045190 ! isotype switching relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000973 name: IgA memory B cell namespace: cell def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:dsd, GOC:msz, ISBN:0781765196] comment: IgA memory B cell are also reportedly RORalpha-positive. synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex relationship: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex [Term] id: CL:0000974 name: long lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4 intersection_of: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1 intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0000975 ! short lived plasma cell relationship: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4 relationship: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1 relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0000975 name: short lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: bearer_of PATO:0001604 ! decreased life span relationship: bearer_of PATO:0001604 ! decreased life span relationship: develops_from CL:0000980 ! plasmablast [Term] id: CL:0000976 name: IgA short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071746 ! IgA immunoglobulin complex, circulating relationship: secretes GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000977 name: IgG short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071736 ! IgG immunoglobulin complex, circulating relationship: secretes GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000978 name: IgM short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071754 ! IgM immunoglobulin complex, circulating relationship: secretes GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000979 name: IgG memory B cell namespace: cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0000980 name: plasmablast namespace: cell def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2673126] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. xref: FMA:84371 is_a: CL:0000785 {is_inferred="true"} ! mature B cell is_a: CL:0000946 ! antibody secreting cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 intersection_of: secretes GO:0042571 ! immunoglobulin complex, circulating relationship: develops_from CL:0000785 ! mature B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: secretes GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000981 name: double negative memory B cell namespace: cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm] synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule [Term] id: CL:0000982 name: IgG plasmablast namespace: cell def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071736 ! IgG immunoglobulin complex, circulating relationship: secretes GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000983 name: IgM plasmablast namespace: cell def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071754 ! IgM immunoglobulin complex, circulating relationship: secretes GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000984 name: IgA plasmablast namespace: cell def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071746 ! IgA immunoglobulin complex, circulating relationship: secretes GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000985 name: IgG plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071736 ! IgG immunoglobulin complex, circulating relationship: secretes GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000986 name: IgM plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071754 ! IgM immunoglobulin complex, circulating relationship: secretes GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000987 name: IgA plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071746 ! IgA immunoglobulin complex, circulating relationship: secretes GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000988 name: hematopoietic cell namespace: cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell namespace: cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [GO_REF:0000031, GOC:amm, GOC:dsd, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000990 name: conventional dendritic cell namespace: cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell namespace: cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C intersection_of: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0032606 ! capable_of type I interferon production relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C relationship: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0032606 ! capable_of type I interferon production [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000997 name: immature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000998 name: CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [GO_REF:0000031, GOC:amm, http:www.immgen.org/index_content.html, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). synonym: "DC.8-4-11b-" EXACT [] synonym: "triple negative dendritic cell" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002474 ! capable_of antigen processing and presentation of peptide antigen via MHC class I relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002474 ! capable_of antigen processing and presentation of peptide antigen via MHC class I [Term] id: CL:0000999 name: CD4-positive CD11b-positive dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). synonym: "DC.4+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0050728 ! capable_of negative regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0050728 ! capable_of negative regulation of inflammatory response [Term] id: CL:0001000 name: CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). synonym: "DC.8+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I intersection_of: RO:0002215 GO:0050729 ! capable_of positive regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: RO:0002215 GO:0050729 ! capable_of positive regulation of inflammatory response [Term] id: CL:0001001 name: immature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001002 name: mature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0001003 name: mature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001004 name: immature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001005 name: mature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001006 name: dermal dendritic cell namespace: cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). xref: BTO:0004812 is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: part_of UBERON:0002067 ! dermis relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: part_of UBERON:0002067 ! dermis [Term] id: CL:0001007 name: interstitial dendritic cell namespace: cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001300 ! CD209 molecule intersection_of: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4 intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001300 ! CD209 molecule relationship: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4 relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 intersection_of: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0001009 name: immature dermal dendritic cell namespace: cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001010 name: mature dermal dendritic cell namespace: cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001009 ! immature dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001011 name: immature interstitial dendritic cell namespace: cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001013 name: mature interstitial dendritic cell namespace: cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001011 ! immature interstitial dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001014 name: CD1a-positive Langerhans cell namespace: cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. synonym: "CD1a-LC" EXACT [] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_plasma_membrane_part PR:000001447 ! epithelial cadherin intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000001447 ! epithelial cadherin relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0001015 name: CD8_alpha-low Langerhans cell namespace: cell def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75 intersection_of: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75 relationship: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell namespace: cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell namespace: cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001018 name: immature CD8_alpha-low Langerhans cell namespace: cell def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001020 name: mature CD8_alpha-low Langerhans cell namespace: cell def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0001022 name: CD115-positive monocyte namespace: cell def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 {is_inferred="true"} ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 {is_inferred="true"} ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell namespace: cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871] xref: CALOHA:TS-0448 xref: FMA:86475 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001786 ! prominin-1 intersection_of: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001786 ! prominin-1 relationship: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] comment: Markers are associated with mouse cells. synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: develops_from CL:0000936 ! early lymphoid progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001898 ! neprilysin relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell namespace: cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell namespace: cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA [Term] id: CL:0001029 name: common dendritic progenitor namespace: cell def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). synonym: "CDP" EXACT [PMID:21219184] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [PMID:21219184] is_a: CL:0000763 ! myeloid cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell namespace: cell def: "Granule cell that is part of the cerebellum." [GOC:mah] xref: BTO:0004278 is_a: CL:0000120 {is_inferred="true"} ! granule cell is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0001032 name: cortical granule cell namespace: cell def: "Granule cell that is part of the cerebral cortex." [GOC:mah] is_a: CL:0000120 ! granule cell is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0001033 name: hippocampal granule cell namespace: cell def: "Granule cell that is part of the hippocampus." [GOC:mah] is_a: CL:0001032 ! cortical granule cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:0001034 name: cell in vitro namespace: cell def: "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." [ReO:mhb] comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells. is_a: CL:0000000 ! cell is_a: GO:0005623 ! cell created_by: haendel creation_date: 2012-01-12T09:58:38Z [Term] id: CL:0001035 name: bone cell namespace: cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element created_by: adiehl creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001039 name: terminally differentiated osteoblast namespace: cl def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VSAO:curator] xref: VSAO:0000116 is_a: CL:0000062 ! osteoblast [Term] id: CL:0001040 name: non-terminally differentiated osteoblast namespace: cl def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 xref: VSAO:0000117 is_a: CL:0000062 ! osteoblast is_a: CL:0001035 ! bone cell relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [GOC:dsd, PMID:19609979] comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ T-lymphocyte " EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0032689 ! capable_of negative regulation of interferon-gamma production intersection_of: RO:0002215 GO:0042130 ! capable_of negative regulation of T cell proliferation relationship: has_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0032689 ! capable_of negative regulation of interferon-gamma production relationship: RO:0002215 GO:0042130 ! capable_of negative regulation of T cell proliferation [Term] id: CL:0001042 name: T-helper 22 cell namespace: cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [GOC:dsd, PMID:19578368, PMID:19578369] comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: RO:0002215 GO:0032626 ! capable_of interleukin-22 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: RO:0002215 GO:0032626 ! capable_of interleukin-22 production [Term] id: CL:0001043 name: activated CD4-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD4+ T cell" BROAD [PMID:22343568] synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001044 name: effector CD4-positive, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568] synonym: "effector CD4+ T cell" BROAD [PMID:22343568] synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy." EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0001045 name: naive CCR4-positive regulatory T cell namespace: cell def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "naive CCR4+ Treg" EXACT [PMID:22343568] synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "naive CCR4-positive regulatory T-cell" EXACT [] synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002677 ! naive regulatory T cell intersection_of: CL:0002677 ! naive regulatory T cell intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 intersection_of: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 relationship: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO [Term] id: CL:0001046 name: memory CCR4-positive regulatory T cell namespace: cell def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "memory CCR4+ Treg" EXACT [PMID:22343568] synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "memory CCR4-positive regulatory T-cell" EXACT [] synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002678 ! memory regulatory T cell intersection_of: CL:0002678 ! memory regulatory T cell intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 [Term] id: CL:0001047 name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "CCR+ Treg" EXACT [PMID:22343568] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 [Term] id: CL:0001048 name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human namespace: cell def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CCR4+ Treg" EXACT [PMID:22343568] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell intersection_of: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001049 name: activated CD8-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD8+ T cell" BROAD [PMID:22343568] synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell intersection_of: CL:0000906 ! activated CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001050 name: effector CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. synonym: "effector CD8+ T cell" BROAD [PMID:22343568] synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Th1/Th17 CD4+ T cell" BROAD [PMID:22343568] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0001052 name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells. synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [PMID:22343568] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0001053 name: IgD-negative memory B cell namespace: cell def: "A memory B cell that lacks expression of surface IgD." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. synonym: "IgD- memory B cell" EXACT [PMID:22343568] is_a: CL:0000787 ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0001054 name: CD14-positive monocyte namespace: cell def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. synonym: "monocyte" NARROW [PMID:22343568] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0001055 name: CD14-positive, CD16-low monocyte namespace: cell def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [GOC:add, PMID:20628149] comment: Definition is valid for human intermediate monocytes. synonym: "intermediate monocyte, human" EXACT [] is_a: CL:0002393 ! intermediate monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte intersection_of: CL:0002393 ! intermediate monocyte intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule [Term] id: CL:0001056 name: dendritic cell, human namespace: cell def: "A dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells. synonym: "dendritic cell" BROAD [PMID:22343568] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001057 name: myeloid dendritic cell, human namespace: cell def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells. synonym: "myeloid dendritic cell" BROAD [PMID:22343568] is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0001056 ! dendritic cell, human intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001058 name: plasmacytoid dendritic cell, human namespace: cell def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells. synonym: "plasmacytoid dendritic cell" BROAD [PMID:22343568] is_a: CL:0000784 ! plasmacytoid dendritic cell is_a: CL:0001056 ! dendritic cell, human intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-GEMM" RELATED [ISBN:0878932437] synonym: "CFU-S" RELATED [ISBN:0878932437] synonym: "CMP" BROAD [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] is_a: CL:0000049 ! common myeloid progenitor intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: RO:0002215 GO:0002573 ! capable_of myeloid leukocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: RO:0002215 GO:0002573 ! capable_of myeloid leukocyte differentiation relationship: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: bearer_of PATO:0001401 ! oligopotent intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: bearer_of PATO:0001401 ! oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001062 name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated namespace: cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [GOC:add, GOC:dos, PMID:15032595, PMID:16237082] comment: This cell type is seen human but not found in the mouse. synonym: "TEMRA" EXACT [PMID:16237082] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: develops_from CL:0000913 ! effector memory CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004230 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] comment: Markers found on mouse cells. is_a: CL:0000038 {is_inferred="true"} ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001345 ! endoglin relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] comment: Markers are found on mouse cells. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor relationship: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell markers associated with human cells. xref: FMA:83517 is_a: CL:0000038 {is_inferred="true"} ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:14:30Z [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast namespace: cell def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell surface markers are associated with human cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:31:50Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-13T03:43:12Z [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [GOC:tfm, PMID:17582345] comment: Markers are found on mouse cells. is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-14T03:25:15Z [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [GOC:tfm, PMCID:PMC2626675] comment: Markers are associated with human cells. is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-14T03:25:17Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] synonym: "MDP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation created_by: tmeehan creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell namespace: cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] comment: Markers are associated with mouse cells. synonym: "murine MDP" EXACT [] is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor created_by: tmeehan creation_date: 2010-01-26T02:43:40Z [Term] id: CL:0002012 name: Kit-low proerythroblast namespace: cell def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] comment: Markers are associated with mouse cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell relationship: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002013 name: GlyA-positive basophillic erythroblast namespace: cell def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers are associated with human cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-04-26T10:41:15Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast namespace: cell def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002012 ! Kit-low proerythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast namespace: cell def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast namespace: cell def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] comment: Cell surface markers are associated with human cells. is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:53:16Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts namespace: cell def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast namespace: cell def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers associated with human cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 created_by: tmeehan creation_date: 2010-04-26T11:04:21Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte namespace: cell def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294] comment: Marker associated with mouse cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002020 name: GlyA-positive reticulocytes namespace: cell def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers is associated with human cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T11:48:25Z [Term] id: CL:0002021 name: GlyA-positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094] comment: Marker is associated with human cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T11:51:22Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084] comment: Marker is associated with mouse cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-04-26T11:51:27Z [Term] id: CL:0002023 name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell namespace: cell def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are associated with human cell type. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-26T02:39:09Z [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553] comment: Markers are associated with mouse cells. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T02:39:15Z [Term] id: CL:0002025 name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb intersection_of: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain created_by: tmeehan creation_date: 2010-04-26T03:52:47Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell namespace: cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm] comment: Markers are commonly associated with mouse cells. is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002028 name: basophil mast progenitor cell namespace: cell def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421] comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. synonym: "BMCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation intersection_of: RO:0002215 GO:0060374 ! capable_of mast cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: RO:0002215 GO:0060374 ! capable_of mast cell differentiation created_by: tmeehan creation_date: 2010-04-27T12:46:33Z [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor namespace: cell def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [GOC:tfm, PMCID:PMC1312421] is_a: CL:0000831 {is_inferred="true"} ! mast cell progenitor intersection_of: CL:0000831 ! mast cell progenitor intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000009143 ! integrin beta-7 intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000009143 ! integrin beta-7 relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:19Z [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell namespace: cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [GOC:tfm, PMCID:PMC1312421] comment: Markers are associated with mouse cells. is_a: CL:0000613 {is_inferred="true"} ! basophil progenitor cell intersection_of: CL:0000613 ! basophil progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:32Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001400 ! unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: bearer_of PATO:0001400 ! unipotent relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001401 ! oligopotent relationship: bearer_of PATO:0001401 ! oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. synonym: "ST stem cell" EXACT [] synonym: "ST-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: develops_from CL:0002034 ! long term hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 created_by: tmeehan creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] comment: Markers are associated with mouse cells. synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 created_by: tmeehan creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 created_by: tmeehan creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "KSL cell" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: develops_from CL:0002033 ! short term hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell namespace: cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:tfm, PMID:16048545] synonym: "memory alpha beta IEL" EXACT [PMID:16048545] is_a: CL:0000793 {is_inferred="true"} ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 created_by: tmeehan creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell namespace: cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402, PMID:20107805, PMID:22043829] synonym: "follicular B helper T cell" RELATED [PMID:22043829] synonym: "follicular helper T cell" RELATED [PMID:22649468] synonym: "follicular helper T-cell" RELATED [PMID:22508770] synonym: "follicular T cell" RELATED [PMID:20107805, PMID:21914188] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [PMID:22552227] synonym: "T(FH)" EXACT [PMID:20207847] synonym: "Tfh" EXACT [PMID:20107805, PMID:20383172] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000003450 ! B-cell lymphoma 6 protein intersection_of: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5 intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: RO:0002215 GO:0045830 ! capable_of positive regulation of isotype switching intersection_of: RO:0002215 GO:0051024 ! capable_of positive regulation of immunoglobulin secretion relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000003450 ! B-cell lymphoma 6 protein relationship: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5 relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: RO:0002215 GO:0045830 ! capable_of positive regulation of isotype switching relationship: RO:0002215 GO:0051024 ! capable_of positive regulation of immunoglobulin secretion created_by: tmeehan creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I namespace: cell def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:17589542] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II namespace: cell def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002039 ! immature NK T cell stage I relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III namespace: cell def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2 intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002040 ! immature NK T cell stage II relationship: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV namespace: cell def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2 intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002041 ! immature NK T cell stage III relationship: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein created_by: tmeehan creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell namespace: cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [GOC:ak, GOC:tfm] comment: Markers are associated with mouse cells. is_a: CL:0002028 {is_inferred="true"} ! basophil mast progenitor cell intersection_of: CL:0002028 ! basophil mast progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:38Z [Term] id: CL:0002045 name: Fraction A pre-pro B cell namespace: cell def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343] comment: Markers associated with mouse cells. synonym: "fraction A" EXACT [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 created_by: tmeehan creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: early pro-B cell namespace: cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination created_by: tmeehan creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002047 name: Fraction B precursor B cell namespace: cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. synonym: "Fr. B" EXACT [] synonym: "Fraction B" EXACT [] is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell intersection_of: CL:0002400 ! Fraction B/C precursor B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase created_by: tmeehan creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell namespace: cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0002046 ! early pro-B cell relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 created_by: tmeehan creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: Fraction C precursor B cell namespace: cell def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343] synonym: "Fraction C" RELATED [] is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell intersection_of: CL:0002400 ! Fraction B/C precursor B cell intersection_of: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination intersection_of: has_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: develops_from CL:0002047 ! Fraction B precursor B cell relationship: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: has_part PR:000001858 ! immunoglobulin iota chain relationship: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2 created_by: tmeehan creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: Fraction C' precursor B cell namespace: cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343] synonym: "Fr. C'" EXACT [] synonym: "Fraction C-prime" EXACT [] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: develops_from CL:0002049 ! Fraction C precursor B cell relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase created_by: tmeehan creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell namespace: cell def: "A pre-BCR positive T cell that is CD38-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cells. synonym: "large pre-B cell type I" RELATED [] is_a: CL:0000952 {is_inferred="true"} ! preBCR-positive large pre-B-II cell intersection_of: CL:0000952 ! preBCR-positive large pre-B-II cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: develops_from CL:0002048 ! late pro-B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 created_by: tmeehan creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: Fraction D precursor B cell namespace: cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343, PMID:18432934] comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. synonym: "Fr. D" EXACT [] synonym: "Fraction D pre-B cell" EXACT [GOC:tfm] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: develops_from CL:0002050 ! Fraction C' precursor B cell relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex created_by: tmeehan creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell namespace: cell def: "A small pre-B cell that is CD22-positive and CD38-low." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell. RAG expression maybe diminishing. synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 {is_inferred="true"} ! small pre-B-II cell intersection_of: CL:0000954 ! small pre-B-II cell intersection_of: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell relationship: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 created_by: tmeehan creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: Fraction E immature B cell namespace: cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, PMID:17582343, PMID:18432934] comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative. is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0002052 ! Fraction D precursor B cell relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha created_by: tmeehan creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell namespace: cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell type. is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22 intersection_of: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell relationship: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22 relationship: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2 relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 created_by: tmeehan creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: Fraction F mature B cell namespace: cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, PMID:17582343] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: develops_from CL:0002054 ! Fraction E immature B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor created_by: tmeehan creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative classical monocyte namespace: cell def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." [GOC:add, GOC:tfm, PMID:15615263, PMID:1706877, PMID:19689341, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. synonym: "CD16- monocyte" EXACT [PMID:22343568] synonym: "CD16-negative monocyte" EXACT [] is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low non-classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [GOC:tfm, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte relationship: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R created_by: tmeehan creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8alpha-positive thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage namespace: cell def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_part CHEBI:25179 ! melanin intersection_of: part_of UBERON:0002097 ! skin of body relationship: has_part CHEBI:25179 ! melanin relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell namespace: cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [GOC:tfm, PMID:18931678, PMID:19604299, PMID:20154671] synonym: "T helper cells type 9" EXACT [] synonym: "T(H)-9 cell" EXACT [] synonym: "Th9" EXACT [PMID:18931678] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B intersection_of: RO:0002215 GO:0002215 ! capable_of defense response to nematode intersection_of: RO:0002215 GO:0032638 ! capable_of interleukin-9 production relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B relationship: RO:0002215 GO:0002215 ! capable_of defense response to nematode relationship: RO:0002215 GO:0032638 ! capable_of interleukin-9 production created_by: tmeehan creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002062 name: type I pneumocyte namespace: cell def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144] synonym: "AT1" EXACT [] synonym: "ATI" EXACT [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "type 1 pneumocyte" EXACT [] synonym: "type I alveolar cells" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] xref: BTO:0000780 xref: FMA:62500 is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: RO:0002215 GO:0007585 ! capable_of respiratory gaseous exchange relationship: RO:0002215 GO:0007585 ! capable_of respiratory gaseous exchange created_by: tmeehan creation_date: 2010-06-23T04:37:54Z [Term] id: CL:0002063 name: type II pneumocyte namespace: cell def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:8540632] synonym: "AT2" EXACT [] synonym: "ATII" EXACT [] synonym: "cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "great alveolar cell" EXACT [] synonym: "lung type 2 cell" EXACT [] synonym: "lung type II cell" RELATED [] synonym: "TII" EXACT [] synonym: "type 2 alveolar epithelial cell" EXACT [] synonym: "type 2 alveolocyte" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar cell" EXACT [] synonym: "type II alveolar epithelial cell" EXACT [] synonym: "type II alveolocyte" EXACT [] xref: BTO:0000538 xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000322 ! pneumocyte intersection_of: RO:0002215 GO:0032940 ! capable_of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell relationship: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis created_by: tmeehan creation_date: 2010-06-24T12:04:13Z [Term] id: CL:0002064 name: pancreatic acinar cell namespace: cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: has_part GO:0042589 ! zymogen granule membrane relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell namespace: cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] synonym: "P cell" BROAD [] synonym: "respiratory enterochromaffin cell " EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell created_by: tmeehan creation_date: 2010-06-28T08:24:30Z [Term] id: CL:0002067 name: type A enterocrine cell namespace: cell def: "An enterocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: RO:0002215 GO:0070091 ! capable_of glucagon secretion relationship: RO:0002215 GO:0070091 ! capable_of glucagon secretion created_by: tmeehan creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte namespace: cell def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002069 name: type II vestibular sensory cell namespace: cell def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651] synonym: "type 2 vestibular hair cell" EXACT [] synonym: "type 2 vestibular sensory cell" EXACT [] synonym: "type II hair cell" EXACT [] xref: FMA:67909 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:13Z [Term] id: CL:0002070 name: type I vestibular sensory cell namespace: cell def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651] synonym: "type 1 vestibular hair cell" EXACT [] synonym: "type 1 vestibular sensory cell" EXACT [] synonym: "type I hair cell" EXACT [] xref: FMA:62352 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:19Z [Term] id: CL:0002071 name: enterocyte of epithelium of large intestine namespace: cell def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [GOC:tfm, ISBN:0517223651] synonym: "columnar cell" BROAD [] synonym: "columnar cell of the colon" EXACT [] synonym: "vacuolar absorptive cell" EXACT [] xref: BTO:0002484 xref: FMA:63638 xref: FMA:66771 is_a: CL:0000584 ! enterocyte is_a: CL:0002253 {is_inferred="true"} ! epithelial cell of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001278 ! epithelium of large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine created_by: tmeehan creation_date: 2010-06-29T11:07:25Z [Term] id: CL:0002072 name: nodal myocyte namespace: cell def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte namespace: cell def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell namespace: cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002075 name: brush cell of trachebronchial tree namespace: cell def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "pulmonary brush cell" RELATED [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002204 ! brush cell intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-06-29T03:22:46Z [Term] id: CL:0002076 name: endo-epithelial cell namespace: cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] xref: FMA:69075 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000223 ! endodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell namespace: cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000221 ! ectodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell namespace: cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000222 ! mesodermal cell created_by: tmeehan creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell namespace: cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] xref: FMA:63099 is_a: CL:1000488 ! cholangiocyte is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct intersection_of: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001064 ! ventral pancreatic duct relationship: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity created_by: tmeehan creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell namespace: cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: part_of UBERON:0001263 ! pancreatic acinus intersection_of: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001263 ! pancreatic acinus relationship: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity created_by: tmeehan creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002081 name: type II cell of carotid body namespace: cell def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227] synonym: "sheath cell of carotid body" EXACT [] xref: FMA:84187 is_a: CL:0000703 ! sustentacular cell is_a: CL:0002256 ! supporting cell of carotid body created_by: tmeehan creation_date: 2010-06-30T04:23:42Z [Term] id: CL:0002082 name: type II cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm] synonym: "adremergic chromaffin cell" EXACT [] synonym: "adrenal secreting cell of the adrenal medulla" EXACT [] synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrine secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla intersection_of: RO:0002215 GO:0048242 ! capable_of epinephrine secretion relationship: part_of UBERON:0001236 ! adrenal medulla relationship: RO:0002215 GO:0048242 ! capable_of epinephrine secretion created_by: tmeehan creation_date: 2010-07-14T09:41:42Z [Term] id: CL:0002083 name: type I cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X] synonym: "noradrenergic chromaffin cell" EXACT [] xref: FMA:69321 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000459 ! norepinephrin secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla intersection_of: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion relationship: part_of UBERON:0001236 ! adrenal medulla relationship: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion created_by: tmeehan creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell namespace: cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell] synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] synonym: "Bottcher's cell" EXACT [] is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-07-14T03:22:02Z [Term] id: CL:0002085 name: tanycyte namespace: cell alt_id: CL:0000643 def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte] synonym: "stretch cell" EXACT [] xref: BTO:0001953 xref: FMA:54560 is_a: CL:0000683 ! ependymoglial cell created_by: tmeehan creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte namespace: cell def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte namespace: cell def: "A leukocyte that lacks granules." [GOC:tfm] synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: lacks_part GO:0030141 ! secretory granule relationship: lacks_part GO:0030141 ! secretory granule created_by: tmeehan creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal namespace: cell def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: RO:0002215 GO:0043134 ! capable_of regulation of hindgut contraction relationship: RO:0002215 GO:0043134 ! capable_of regulation of hindgut contraction created_by: tmeehan creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002089 name: nuocyte namespace: cell def: "A leukocyte cell capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:tfm, PMID:20200518] is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B intersection_of: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2 intersection_of: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5 intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032616 ! capable_of interleukin-13 production relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B relationship: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2 relationship: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1 relationship: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5 relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable_of interleukin-13 production created_by: tmeehan creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002090 name: polar body namespace: cell def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X] xref: EHDAA2:0004716 xref: FMA:85543 xref: WBbt:0008429 xref: XAO:0000262 is_a: CL:0000021 ! female germ cell created_by: tmeehan creation_date: 2010-08-23T09:49:53Z [Term] id: CL:0002091 name: primary polar body namespace: cell def: "A small cell formed by the first meiotic division of oocytes." [GOC:tfm, ISBN:068340007X] synonym: "first polar body" EXACT [EHDAA2:0000541] synonym: "polocytus primarius" EXACT [FMA:18650] xref: EHDAA2:0000541 xref: EMAPA:16032 xref: FMA:18650 xref: VHOG:0000464 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:49:58Z [Term] id: CL:0002092 name: bone marrow cell namespace: cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. xref: BTO:0004850 xref: FMA:83621 is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002093 name: secondary polar body namespace: cell def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [GOC:tfm, ISBN:068340007X] synonym: "polocytus secundarius" EXACT [FMA:18651] synonym: "second polar body" EXACT [EHDAA2:0001820] xref: EHDAA2:0001820 xref: EMAPA:16034 xref: EMAPA:16045 xref: FMA:18651 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:50:01Z [Term] id: CL:0002094 name: interstitial cell of ovary namespace: cell def: "A cell that makes up the loose connective tissue of the ovary." [GOC:tfm] xref: FMA:18709 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:11:34Z [Term] id: CL:0002095 name: hilus cell of ovary namespace: cell def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002096 name: internodal tract myocyte namespace: cell def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300] xref: FMA:223275 is_a: CL:0002086 ! specialized cardiac myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract created_by: tmeehan creation_date: 2010-08-23T11:24:11Z [Term] id: CL:0002097 name: cortical cell of adrenal gland namespace: cell def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm] synonym: "adrenal cortex cell" EXACT [] synonym: "adrenocortical cell" EXACT [] xref: FMA:69545 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex created_by: tmeehan creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002098 name: regular cardiac myocyte namespace: cell def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." [GOC:tfm] synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] xref: FMA:67967 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-08-23T11:33:10Z [Term] id: CL:0002099 name: type I cell of adrenal cortex namespace: cell alt_id: CL:1000423 def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651] synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT [] xref: FMA:69273 is_a: CL:0000456 ! mineralocorticoid secreting cell is_a: CL:0002097 {is_inferred="true"} ! cortical cell of adrenal gland intersection_of: CL:0002097 ! cortical cell of adrenal gland intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:42:02Z [Term] id: CL:0002100 name: regular interventricular cardiac myocyte namespace: cell def: "A regular cardiac myocyte of the interventricular region of the heart." [GOC:tfm] xref: FMA:228792 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:40:52Z [Term] id: CL:0002101 name: CD38-positive naive B cell namespace: cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002102 name: CD38-negative naive B cell namespace: cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002103 name: IgG-positive double negative memory B cell namespace: cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002104 name: IgG-negative double negative memory B cell namespace: cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002105 name: CD38-positive IgG memory B cell namespace: cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell namespace: cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell namespace: cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0001053 ! IgD-negative memory B cell is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0002108 name: CD38-negative IgG memory B cell namespace: cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell namespace: cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell namespace: cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002109 ! B220-positive CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell namespace: cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell namespace: cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell namespace: cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell namespace: cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell namespace: cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell namespace: cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002117 name: IgG-negative class switched memory B cell namespace: cell def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell namespace: cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production created_by: tmeehan creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta-17 cells" EXACT [PMID:21976777] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: RO:0002215 GO:0032620 ! capable_of interleukin-17 production relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: RO:0002215 GO:0032620 ! capable_of interleukin-17 production created_by: tmeehan creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell namespace: cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [GOC:tfm, PMID:19270712] is_a: CL:0000799 {is_inferred="true"} ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000799 ! immature gamma-delta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule intersection_of: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 intersection_of: part_of UBERON:0002370 ! thymus relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule relationship: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell namespace: cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [GOC:tfm, PMID:20581831] is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: RO:0002215 GO:0045087 ! capable_of innate immune response created_by: tmeehan creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [GOC:add, GOC:dsd, GOC:tfm, PMID:19201830, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). synonym: "Tc17 CD8+ T cell" EXACT [PMID:22343568] synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5 intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002215 GO:0032620 ! capable_of interleukin-17 production relationship: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5 relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002215 GO:0032620 ! capable_of interleukin-17 production [Term] id: CL:0002129 name: regular atrial cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac atrium." [GOC:tfm] synonym: "atrial cardiac muscle cell" EXACT [GOC:pr] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] xref: FMA:83108 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:03Z [Term] id: CL:0002130 name: regular interatrial cardiac myocyte namespace: cell def: "A cardiac myocyte of the interatrial region of the heart." [GOC:tfm] xref: FMA:228790 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:09Z [Term] id: CL:0002131 name: regular ventricular cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac ventricle." [GOC:tfm] synonym: "regular cardiac muscle cell of ventricle" EXACT [] synonym: "regular ventricular cardiac muscle fiber" EXACT [] synonym: "ventricular cardiac muscle cell" BROAD [GOC:pr] synonym: "ventricular myocyte" EXACT [] xref: FMA:83109 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:13Z [Term] id: CL:0002132 name: stromal cell of ovary namespace: cell def: "A stomal cell of the ovary" [GOC:tfm] synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad created_by: tmeehan creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002133 name: stromal cell of ovarian cortex namespace: cell def: "A stromal cell of the ovarian cortex." [GOC:tfm] xref: FMA:256169 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T12:12:15Z [Term] id: CL:0002134 name: stromal cell of ovarian medulla namespace: cell def: "A stromal cell of the ovarian medulla." [GOC:tfm] xref: FMA:256171 is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0013192 ! ovarian medulla relationship: part_of UBERON:0013192 ! ovarian medulla created_by: tmeehan creation_date: 2010-08-23T12:12:17Z [Term] id: CL:0002135 name: nonkeratinized cell of epidermis namespace: cell def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [GO:tfm, PMID:1987287] xref: FMA:62880 is_a: CL:0000362 ! epidermal cell relationship: part_of UBERON:0001003 ! epidermis created_by: tmeehan creation_date: 2010-08-24T08:43:27Z [Term] id: CL:0002136 name: type II cell of adrenal cortex namespace: cell def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651] synonym: "type II cortical cell of adrenal gland" EXACT [] xref: FMA:69547 is_a: CL:0000460 ! glucocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:42Z [Term] id: CL:0002137 name: type III cell of adrenal cortex namespace: cell def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651] xref: FMA:69564 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:44Z [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel namespace: cell alt_id: CL:1000421 def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148] synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] xref: BTO:0004167 xref: FMA:68458 is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: develops_from CL:0005022 ! vascular lymphangioblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: develops_from CL:0005022 ! vascular lymphangioblast relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002139 name: endothelial cell of vascular tree namespace: cell def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002140 name: acinar cell of sebaceous gland namespace: cell alt_id: CL:0002587 def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." [GOC:tfm] synonym: "sebocyte" EXACT [] xref: BTO:0004613 xref: FMA:70953 is_a: CL:0000317 {is_inferred="true"} ! sebum secreting cell is_a: CL:0000622 ! acinar cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000317 ! sebum secreting cell intersection_of: part_of UBERON:0003487 ! skin sebaceous gland relationship: part_of UBERON:0003487 ! skin sebaceous gland created_by: tmeehan creation_date: 2010-08-24T09:27:52Z [Term] id: CL:0002141 name: active chief cell of parathyroid gland namespace: cell def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [FMA:0517223651, GOC:tfm] xref: FMA:69082 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T09:30:15Z [Term] id: CL:0002142 name: dark cell of eccrine sweat gland namespace: cell def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [ISBN:0517223651] xref: FMA:70659 is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell created_by: tmeehan creation_date: 2010-08-24T02:15:16Z [Term] id: CL:0002143 name: dark chief cell of parathyroid cell namespace: cell def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69080 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T02:18:36Z [Term] id: CL:0002144 name: capillary endothelial cell namespace: cell def: "An endothelial cell found in capillaries." [GOC:tfm] xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary created_by: tmeehan creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree namespace: cell def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell relationship: develops_from CL:0002209 ! intermediate epitheliocyte created_by: tmeehan creation_date: 2010-08-24T03:38:29Z [Term] id: CL:0002146 name: clear cell of eccrine sweat gland namespace: cell def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [GOC:tfm, ISBN:0517223651] xref: FMA:70658 is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell created_by: tmeehan creation_date: 2010-08-24T10:33:02Z [Term] id: CL:0002147 name: clear chief cell of parathyroid cell namespace: cell def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [GOC:tfm, ISBN:0618947256] xref: FMA:69081 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T10:39:42Z [Term] id: CL:0002148 name: dental pulp cell namespace: cell def: "A cell found within the dental pulp." [GOC:tfm, PMID:11087820] xref: BTO:0000339 xref: CALOHA:TS-0195 xref: FMA:87170 is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002320 ! connective tissue cell relationship: part_of UBERON:0001754 ! dental pulp created_by: tmeehan creation_date: 2010-08-24T02:52:09Z [Term] id: CL:0002149 name: epithelial cell of uterus namespace: cell alt_id: CL:1000294 def: "An epithelial cell of the uterus." [GOC:tfm] xref: FMA:256161 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2010-08-24T10:45:54Z [Term] id: CL:0002150 name: epithelioid macrophage namespace: cell def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [MESH:A11.329.372.300, PMID:12673090] synonym: "epithelioid cell" BROAD [] synonym: "epithelioid histocyte" EXACT [MESH:A11.329.372.300, PMID:12673090] synonym: "epitheloid macrophage" EXACT [] xref: FMA:83514 is_a: CL:0000235 ! macrophage relationship: develops_from CL:0000861 ! elicited macrophage created_by: tmeehan creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002151 name: late promyelocyte namespace: cell def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [ISBN:0412046911] xref: FMA:83534 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:50Z [Term] id: CL:0002152 name: columnar cell of endocervix namespace: cell def: "A columnar cell of the cervix uteri." [GOC:tfm, ISBN:0721662544] xref: FMA:86486 is_a: CL:0002149 ! epithelial cell of uterus relationship: part_of UBERON:0000458 ! endocervix created_by: tmeehan creation_date: 2010-08-24T10:47:47Z [Term] id: CL:0002153 name: corneocyte namespace: cell def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X] xref: BTO:0001943 xref: FMA:68650 is_a: CL:0000225 ! anucleate cell is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000312 ! keratinocyte relationship: part_of UBERON:0002027 ! stratum corneum of epidermis created_by: tmeehan creation_date: 2010-08-24T10:53:03Z [Term] id: CL:0002154 name: early promyelocyte namespace: cell def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [FMA:0412046911, GOC:tfm] xref: FMA:83533 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:53Z [Term] id: CL:0002155 name: echinocyte namespace: cell def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [GOC:tfm] synonym: "burr cell" EXACT [] xref: FMA:81099 is_a: CL:0000595 ! enucleate erythrocyte created_by: tmeehan creation_date: 2010-08-24T03:15:21Z [Term] id: CL:0002157 name: endosteal cell namespace: cell def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [FMA:0618947256, GOC:tfm] xref: FMA:86495 is_a: CL:0001035 ! bone cell is_a: CL:0002078 ! meso-epithelial cell relationship: part_of UBERON:0009859 ! endosteum created_by: tmeehan creation_date: 2010-08-24T03:33:58Z [Term] id: CL:0002158 name: external epithelial cell of tympanic membrane namespace: cell def: "Epithelial cell found on the external side of the tympanic membrane" [GOC:tfm, PMID:5686391] xref: FMA:70558 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-25T10:25:31Z [Term] id: CL:0002159 name: general ecto-epithelial cell namespace: cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002160 name: basal external epithelial cell of tympanic membrane namespace: cell def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:44Z [Term] id: CL:0002161 name: superficial external epithelial cell of tympanic membrane namespace: cell def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:48Z [Term] id: CL:0002162 name: internal epithelial cell of tympanic membrane namespace: cell def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [FMA:5686391, GOC:tfm] xref: FMA:70626 is_a: CL:0002076 ! endo-epithelial cell relationship: part_of UBERON:0002364 ! tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:49:46Z [Term] id: CL:0002163 name: internal pillar cell of cochlea namespace: cell def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75722 xref: FMA:75726 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:21Z [Term] id: CL:0002164 name: external pillar cell of cochlea namespace: cell def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75727 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:23Z [Term] id: CL:0002165 name: phalangeal cell namespace: cell def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256] xref: FMA:79800 is_a: CL:0002490 ! organ of Corti supporting cell created_by: tmeehan creation_date: 2010-08-25T01:29:07Z [Term] id: CL:0002166 name: epithelial cell of Malassez namespace: cell def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521] synonym: "epithelial cell rests of Malassez " EXACT [] synonym: "epithelial debris of Malassez" EXACT [] xref: FMA:62987 is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal relationship: part_of UBERON:0011595 ! jaw region created_by: tmeehan creation_date: 2010-08-26T08:51:27Z [Term] id: CL:0002167 name: olfactory epithelial cell namespace: cell def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026] xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T01:47:13Z [Term] id: CL:0002168 name: border cell of cochlea namespace: cell def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [FMA:0412046911, GOC:tfm] xref: FMA:79798 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T01:47:12Z [Term] id: CL:0002169 name: basal cell of olfactory epithelium namespace: cell alt_id: CL:1000395 def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026] synonym: "horizontal basal call" BROAD [] xref: FMA:62303 is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0002167 ! olfactory epithelial cell intersection_of: part_of UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0001997 ! olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:58:54Z [Term] id: CL:0002170 name: keratinized cell of the oral mucosa namespace: cell def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID:12014572] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal is_a: CL:0002336 ! buccal mucosa cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0003729 ! mouth mucosa created_by: tmeehan creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium namespace: cell def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753] synonym: "blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea namespace: cell def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [GOC:tfm, MP:0004482, PMID:2111803] synonym: "interdental cell" EXACT [] xref: FMA:79797 is_a: CL:0002315 ! supporting cell of cochlea relationship: part_of UBERON:0002276 ! lamina of spiral limbus created_by: tmeehan creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell namespace: cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911] synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] synonym: "polar cushion cells" EXACT [] xref: FMA:84143 xref: KUPO:0001033 is_a: CL:0000650 ! mesangial cell is_a: CL:1000500 ! kidney interstitial cell is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell is_a: CL:1001318 ! renal interstitial pericyte intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002321 ! extraglomerular mesangium relationship: part_of UBERON:0002321 ! extraglomerular mesangium created_by: tmeehan creation_date: 2010-08-25T02:20:55Z [Term] id: CL:0002174 name: follicular cell of ovary namespace: cell def: "A cell within the follicle of an ovary." [GOC:tfm] xref: EMAPA:31247 xref: FMA:70589 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-25T03:01:27Z [Term] id: CL:0002175 name: primary follicular cell of ovary namespace: cell def: "A cell within the primary follicle of the ovary." [GOC:tfm] xref: FMA:70590 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:42Z [Term] id: CL:0002176 name: secondary follicular cell of ovary namespace: cell def: "A cell of a secondary follicile within the ovary." [GOC:tfm] xref: FMA:70591 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:48Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis namespace: cell def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000642 ! folliculostellate cell intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002178 name: epithelial cell of stomach namespace: cell alt_id: CL:1000399 def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] xref: FMA:62948 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002179 name: foveolar cell of stomach namespace: cell def: "An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop ." [GOC:tfm, http://www.merriam-webster.com/medical/foveolar] xref: FMA:86552 is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:23:22Z [Term] id: CL:0002180 name: mucous cell of stomach namespace: cell alt_id: CL:1000404 def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: part_of UBERON:0001199 ! mucosa of stomach relationship: part_of UBERON:0001199 ! mucosa of stomach created_by: tmeehan creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002181 name: mucus neck cell of gastric gland namespace: cell alt_id: CL:1000401 def: "A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach." [GOC:tfm, ISBN:0517223651] xref: FMA:62954 is_a: CL:0000651 {is_inferred="true"} ! mucous neck cell is_a: CL:0002180 {is_inferred="true"} ! mucous cell of stomach intersection_of: CL:0000651 ! mucous neck cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:41:30Z [Term] id: CL:0002182 name: surface mucosal cell of stomach namespace: cell def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651] xref: FMA:62949 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002180 ! mucous cell of stomach relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion created_by: tmeehan creation_date: 2010-08-25T03:45:10Z [Term] id: CL:0002183 name: stem cell of gastric gland namespace: cell alt_id: CL:1000400 def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] xref: FMA:62953 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium namespace: cell def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623] synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:22Z [Term] id: CL:0002187 name: basal cell of epidermis namespace: cell alt_id: CL:1000439 def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [GOC:tfm, ISBN:0517223651] xref: FMA:70571 is_a: CL:0000312 ! keratinocyte is_a: CL:0000646 {is_inferred="true"} ! basal cell is_a: CL:1000428 ! stem cell of epidermis intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis created_by: tmeehan creation_date: 2010-08-26T03:12:49Z [Term] id: CL:0002188 name: glomerular endothelial cell namespace: cell def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009] xref: BTO:0004632 xref: FMA:70970 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell is_a: CL:0000666 ! fenestrated cell is_a: CL:1000746 ! glomerular cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus created_by: tmeehan creation_date: 2010-08-26T10:59:44Z [Term] id: CL:0002189 name: granular cell of epidermis namespace: cell def: "A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules." [ISBN:1416031855] xref: FMA:70543 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:19:00Z [Term] id: CL:0002190 name: squamous cell of epidermis namespace: cell def: "A flat keratinocyte immediately below the cornified layer." [GOC:tfm, ISBN:0517223651] xref: FMA:86925 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:37:02Z [Term] id: CL:0002191 name: granulocytopoietic cell namespace: cell def: "A cell involved in the formation of a granulocyte." [GOC:tfm] xref: FMA:83519 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation relationship: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation created_by: tmeehan creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002192 name: metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [GOC:tfm, http://en.wikipedia.org/wiki/Metamyelocyte, ISBN:0721601464] xref: FMA:83541 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0002193 ! myelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:15Z [Term] id: CL:0002193 name: myelocyte namespace: cell def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [GOC:tfm, http://en.wikipedia.org/wiki/Myelocyte, ISBN:0323052908] xref: BTO:0000734 xref: FMA:83525 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:19Z [Term] id: CL:0002194 name: monopoietic cell namespace: cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] xref: FMA:83552 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation created_by: tmeehan creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002195 name: hepatic stem cell namespace: cell def: "A stem cell that can give rise to the cells of the liver." [GOC:tfm] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell namespace: cell alt_id: CL:1000036 def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [PMID:17901986] synonym: "hepatic oval cell" EXACT [] xref: BTO:0004270 xref: FMA:86576 is_a: CL:0002195 ! hepatic stem cell created_by: tmeehan creation_date: 2010-08-30T02:01:49Z [Term] id: CL:0002197 name: inactive chief cell of parathyoid gland namespace: cell def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [GOC:tfm, ISBN:0517223651] is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:14:01Z [Term] id: CL:0002198 name: oncocyte namespace: cell def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317] synonym: "oxyphil" EXACT [] xref: FMA:67606 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T11:26:49Z [Term] id: CL:0002199 name: oxyphil cell of parathyroid gland namespace: cell def: "An oncocyte located in the parathyroid gland." [PMID:20013317] xref: FMA:69084 is_a: CL:0002198 ! oncocyte is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:23Z [Term] id: CL:0002200 name: oxyphil cell of thyroid namespace: cell def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317] synonym: "Askanazy cells" EXACT [] synonym: "Hurthle cells" EXACT [] xref: FMA:87169 is_a: CL:0002198 ! oncocyte is_a: CL:0002257 ! epithelial cell of thyroid gland intersection_of: CL:0002198 ! oncocyte intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:26Z [Term] id: CL:0002201 name: renal beta-intercalated cell namespace: cell def: "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." [GOC:tfm, PMID:11781354] is_a: CL:0005010 ! renal intercalated cell created_by: tmeehan creation_date: 2010-09-02T01:43:55Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree namespace: cell alt_id: CL:1000407 def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002203 name: Brush cell of epithelium proper of large intestine namespace: cell alt_id: CL:1000387 def: "Brush cell found in the epithelial layer of the colon." [GOC:tfm] comment: Brush cells are a distinct cell type from brush border cell-types. xref: FMA:263222 is_a: CL:0002204 ! brush cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-02T02:20:50Z [Term] id: CL:0002204 name: brush cell namespace: cell def: "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "caveolated cell" EXACT [] synonym: "fibrillovesicular cell" EXACT [] synonym: "multivesicular cell" EXACT [] synonym: "tuft cell" EXACT [] xref: FMA:67978 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:28:53Z [Term] id: CL:0002205 name: brush cell of lobular bronchiole namespace: cell alt_id: CL:1000386 def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm] xref: FMA:263220 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002208 ! brush cell of bronchus intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole created_by: tmeehan creation_date: 2010-09-02T02:38:34Z [Term] id: CL:0002206 name: brush cell of terminal bronchiole namespace: cell alt_id: CL:1000390 def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm] xref: FMA:263228 is_a: CL:0002205 ! brush cell of lobular bronchiole intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0001958 ! epithelium of terminal bronchiole relationship: part_of UBERON:0001958 ! epithelium of terminal bronchiole created_by: tmeehan creation_date: 2010-09-02T02:38:36Z [Term] id: CL:0002207 name: brush cell of trachea namespace: cell alt_id: CL:1000388 def: "Brush cell of the epithelium in the trachea." [GOC:tfm] xref: FMA:263224 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea created_by: tmeehan creation_date: 2010-09-02T02:38:37Z [Term] id: CL:0002208 name: brush cell of bronchus namespace: cell alt_id: CL:1000389 def: "A brush cell found in the epithelium of bronchus." [GOC:tfm] xref: FMA:263226 is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus created_by: tmeehan creation_date: 2010-09-02T02:38:42Z [Term] id: CL:0002209 name: intermediate epitheliocyte namespace: cell def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002210 name: red muscle cell namespace: cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651] synonym: "oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] xref: FMA:84448 is_a: CL:0008002 ! skeletal muscle fiber created_by: tmeehan creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell namespace: cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651] synonym: "intermediate muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "slow twitch fiber" EXACT [] synonym: "slow twitch muscle cell" EXACT [] synonym: "slow twitch muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "slow-twitch muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: BTO:0001812 xref: CALOHA:TS-0940 xref: FMA:84413 xref: MESH:A02.633.565.700 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell created_by: tmeehan creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell namespace: cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm] synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] synonym: "type II muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84414 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell namespace: cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651] xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell namespace: cell def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm] synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] synonym: "type 2a muscle cell" EXACT [] synonym: "type 2a muscle fiber" EXACT [] synonym: "type IIa muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84415 is_a: CL:0002210 ! red muscle cell is_a: CL:0002212 ! type II muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell namespace: cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651] synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] synonym: "type IIb muscle fiber" EXACT [] xref: FMA:84416 is_a: CL:0002212 ! type II muscle cell is_a: CL:0002213 ! white muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002216 name: intermediate muscle cell namespace: cell def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [GOC:tfm] xref: FMA:84450 is_a: CL:0008002 ! skeletal muscle fiber created_by: tmeehan creation_date: 2010-09-02T03:51:17Z [Term] id: CL:0002217 name: intermediate trophoblast cell namespace: cell def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] xref: BTO:0002366 xref: FMA:86564 is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:04:36Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002219 name: anchoring trophoblasts namespace: cell def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:14:28Z [Term] id: CL:0002220 name: interstitial cell of pineal gland namespace: cell def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002221 name: keratinized squamous cell of esophagus namespace: cell def: "A squamous cell that has keratin in the esophagus." [GOC:tfm, PMID:11694559] xref: FMA:86549 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2010-09-07T10:11:06Z [Term] id: CL:0002222 name: vertebrate lens cell namespace: cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0000965 ! lens of camera-type eye created_by: tmeehan creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell namespace: cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [GOC:tfm, ISBN:0517223651] xref: FMA:63181 is_a: CL:0002224 ! lens epithelial cell created_by: tmeehan creation_date: 2010-09-07T10:45:45Z [Term] id: CL:0002224 name: lens epithelial cell namespace: cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] xref: FMA:67559 is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: part_of UBERON:0001803 ! epithelium of lens relationship: part_of UBERON:0001803 ! epithelium of lens created_by: tmeehan creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber namespace: cell def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651] synonym: "secondary lens fibre" EXACT [] is_a: CL:0011004 ! lens fiber cell relationship: develops_from CL:0002228 ! primary lens fiber created_by: tmeehan creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002226 name: non-nucleated secondary lens fiber namespace: cell def: "A secondary lens fiber cell that lacks a nucleus." [GOC:tfm] synonym: "non-nucleated secondary lens fibre" EXACT [] xref: FMA:67561 is_a: CL:0002225 ! secondary lens fiber relationship: develops_from CL:0002227 ! nucleated secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:23Z [Term] id: CL:0002227 name: nucleated secondary lens fiber namespace: cell def: "A secondary fiber cell that contains a nucleus." [GOC:tfm] synonym: "nucleated secondary lens fibre" EXACT [] xref: FMA:70949 is_a: CL:0002225 ! secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:26Z [Term] id: CL:0002228 name: primary lens fiber namespace: cell def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704] synonym: "primary lens fibre" EXACT [] xref: FMA:70613 is_a: CL:0011004 ! lens fiber cell relationship: develops_from CL:0002223 ! anterior lens cell created_by: tmeehan creation_date: 2010-09-07T11:19:01Z [Term] id: CL:0002229 name: light chief cell of parathyroid gland namespace: cell def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69079 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-07T11:46:54Z [Term] id: CL:0002231 name: epithelial cell of prostate namespace: cell alt_id: CL:1000295 alt_id: CL:1000408 def: "An epithelial cell of the prostate." [GOC:tfm] synonym: "prostate epithelial cell" EXACT [] xref: FMA:256163 xref: FMA:66817 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-07T01:49:29Z [Term] id: CL:0002232 name: epithelial cell of prostatic duct namespace: cell alt_id: CL:1000462 def: "An epithelial cell of prostatic duct." [GOC:tfm] synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224] xref: FMA:74224 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:55:51Z [Term] id: CL:0002233 name: epithelial cell of prostatic acinus namespace: cell alt_id: CL:1000461 def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349] synonym: "acinar epithelial cell of prostate" EXACT [FMA:74223] xref: FMA:74223 is_a: CL:0002231 {is_inferred="true"} ! epithelial cell of prostate intersection_of: CL:0002231 ! epithelial cell of prostate intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:55:53Z [Term] id: CL:0002234 name: basal cell of prostatic acinus namespace: cell alt_id: CL:1000464 def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm] synonym: "basal epithelial cell of prostatic acinus" EXACT [FMA:74265] xref: FMA:74265 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:59:08Z [Term] id: CL:0002235 name: luminal cell of prostatic acinus namespace: cell def: "A cell of the luminal layer of the epithelium in the prostatic acinus." [GOC:tfm] xref: FMA:74266 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:59:10Z [Term] id: CL:0002236 name: basal epithelial cell of prostatic duct namespace: cell alt_id: CL:1000463 def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377] xref: FMA:74226 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:12Z [Term] id: CL:0002237 name: luminal epithelial cell of prostatic duct namespace: cell def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [GOC:tfm] xref: FMA:74225 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:16Z [Term] id: CL:0002238 name: male gonocyte namespace: cell def: "A primordial germ cell that is destined to become a male germ cell." [GOC:tfm] synonym: "male primordial germ cell" EXACT [] synonym: "testis primordial germ cell" EXACT [VHOG:0000662] xref: EHDAA2:0001053 xref: EMAPA:18686 xref: FMA:84771 xref: VHOG:0000662 is_a: CL:0000670 ! primordial germ cell relationship: part_of UBERON:0000473 ! testis created_by: tmeehan creation_date: 2010-09-07T02:11:13Z [Term] id: CL:0002239 name: ooblast namespace: cell def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [GOC:tfm] synonym: "ovary primordial germ cell" EXACT [VHOG:0000661] synonym: "ovigerm" EXACT [FMA:84772] xref: EHDAA2:0000505 xref: EMAPA:17965 xref: FMA:84772 xref: ISBN:0721662544 xref: VHOG:0000661 is_a: CL:0000670 ! primordial germ cell relationship: part_of UBERON:0000992 ! female gonad created_by: tmeehan creation_date: 2010-09-07T02:11:16Z [Term] id: CL:0002240 name: marrow fibroblast namespace: cell def: "A fibroblast in the bone marrow." [GOC:tfm] xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002241 name: pulmonary interstitial fibroblast namespace: cell def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] synonym: "pulmonary myofibroblast" EXACT [] synonym: "pulmonary septal cell" EXACT [] xref: FMA:84467 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001004 ! respiratory system intersection_of: part_of UBERON:0005169 ! interstitial tissue relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0005169 ! interstitial tissue created_by: tmeehan creation_date: 2010-09-07T02:29:38Z [Term] id: CL:0002242 name: nucleate cell namespace: cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil namespace: cell def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001607 ! sphincter pupillae relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001607 ! sphincter pupillae created_by: tmeehan creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002244 name: squamous cell of ectocervix namespace: cell def: "A nonstratified squamous cell located in the ectocervix." [GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm] synonym: "ectocervical squamous cell" EXACT [] xref: FMA:86483 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-09-08T09:12:23Z [Term] id: CL:0002245 name: obsolete null lymphocyte namespace: cell def: "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." [GOC:tfm, ISBN:068340007X] xref: FMA:83601 is_obsolete: true created_by: tmeehan creation_date: 2010-09-07T03:43:42Z [Term] id: CL:0002246 name: peripheral blood stem cell namespace: cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood created_by: tmeehan creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002247 name: pleural macrophage namespace: cell def: "A tissue macrophage that is in the pleural space." [GOC:tfm] xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002248 name: pluripotent stem cell namespace: cell def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID:19343304] xref: FMA:70570 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-07T04:26:06Z [Term] id: CL:0002249 name: primitive cardiac myocyte namespace: cell def: "A stem cell that can differentiate into a cardiac myocyte." [GOC:tfm, PMID:16938308] xref: FMA:75620 is_a: CL:0000035 ! single fate stem cell is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-07T04:40:32Z [Term] id: CL:0002250 name: intestinal crypt stem cell namespace: cell def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells." [GOC:tfm, ISBN:0517223651] synonym: "stem cell of intestinal crypt of lieberkuhn" EXACT [] xref: FMA:63379 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn created_by: tmeehan creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal namespace: cell def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract created_by: tmeehan creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus namespace: cell alt_id: CL:1000402 def: "An epithelial cell of the esophagus." [GOC:tfm] xref: FMA:63071 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine namespace: cell alt_id: CL:1000292 def: "An epithelial cell of the large intestine." [GOC:tfm] synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine namespace: cell alt_id: CL:1000293 def: "An epithelial cell of the small intestine." [GOC:tfm] xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002255 name: stromal cell of endometrium namespace: cell def: "An epithelial cell that regulates growth and differentiation of the overlying epithelium." [GOC:tfm, PMID:11331626] xref: CALOHA:TS-1266 xref: FMA:86490 is_a: CL:0000499 {is_inferred="true"} ! stromal cell is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2010-09-08T09:50:04Z [Term] id: CL:0002256 name: supporting cell of carotid body namespace: cell def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136] synonym: "carotid body sustentacular cell" EXACT [] xref: FMA:84188 is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-08T10:34:45Z [Term] id: CL:0002257 name: epithelial cell of thyroid gland namespace: cell alt_id: CL:1000297 def: "An epithelial cell of thyroid gland." [GOC:tfm] xref: FMA:256167 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:46:51Z [Term] id: CL:0002258 name: thyroid follicular cell namespace: cell def: "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." [GOC:tfm, ISBN:0517223651] synonym: "follicular cell of thyroid gland" EXACT [] synonym: "principal cell of thyroid gland" EXACT [] synonym: "thyroid gland follicular cell" EXACT [] xref: BTO:0003736 xref: CALOHA:TS-1285 xref: FMA:68782 is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:50:08Z [Term] id: CL:0002259 name: neuroepithelial stem cell namespace: cell def: "The stem cell from which glial precursor cell arises from." [GOC:tfm, PMID:11687496] synonym: "totipotent neuroepithelial stem cell" NARROW [] xref: FMA:87171 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-08T02:14:14Z [Term] id: CL:0002260 name: epithelial cell of parathyroid gland namespace: cell alt_id: CL:1000429 def: "An epithelial cell of the parathyroid gland." [GOC:tfm] xref: FMA:70547 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell is_a: CL:1001593 ! parathyroid glandular cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0001132 ! parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:29:38Z [Term] id: CL:0002261 name: endothelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000446 def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256] xref: FMA:70627 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-14T10:40:12Z [Term] id: CL:0002262 name: endothelial cell of sinusoid namespace: cell alt_id: CL:1000403 def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] xref: FMA:63134 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid created_by: tmeehan creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002263 name: transitional cell of parathyroid gland namespace: cell def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [GOC:tfm, ISBN:0412046911] xref: FMA:69324 is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:33:50Z [Term] id: CL:0002264 name: type A cell of stomach namespace: cell def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] xref: FMA:83411 is_a: CL:0002067 ! type A enterocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enterocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon namespace: cell def: "A D cell located in the colon." [GOC:tfm] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon created_by: tmeehan creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine namespace: cell def: "A type D cell of the small intestine." [GOC:tfm] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach namespace: cell def: "A type D cell found in the stomach." [GOC:tfm] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002268 name: P/D1 enteroendocrine cell namespace: cell def: "An enteroendocrine cell that stores and secretes Ghrelin." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63207 xref: FMA:63418 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell created_by: tmeehan creation_date: 2010-09-10T01:47:45Z [Term] id: CL:0002269 name: vasoactive intestinal peptide secreting cell namespace: cell def: "An endocrine cell that secretes vasoactive intestinal peptide." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T01:52:20Z [Term] id: CL:0002270 name: type EC2 enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:62941 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell created_by: tmeehan creation_date: 2010-09-10T02:13:47Z [Term] id: CL:0002271 name: type EC1 enteroendocrine cell namespace: cell def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651] xref: FMA:62940 is_a: CL:0000505 ! substance P secreting cell is_a: CL:0000577 ! type EC enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T02:13:49Z [Term] id: CL:0002272 name: motilin secreting cell namespace: cell def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [GOC:tfm, MESH:D06.472.317.525] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T02:31:13Z [Term] id: CL:0002273 name: type ECL enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63208 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell created_by: tmeehan creation_date: 2010-09-10T02:35:17Z [Term] id: CL:0002274 name: histamine secreting cell namespace: cell def: "A cell type that secretes histamine." [GOC:tfm] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001821 ! capable_of histamine secretion relationship: RO:0002215 GO:0001821 ! capable_of histamine secretion created_by: tmeehan creation_date: 2010-09-10T03:04:42Z [Term] id: CL:0002275 name: pancreatic PP cell namespace: cell def: "A PP cell located in the islets of the pancreas." [GOC:tfm] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000696 ! PP cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002276 name: obsolete PP cell of pancreatic acinus namespace: cell def: "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." [GOC:tfm] synonym: "type F cell of pancreatic acinus" EXACT [] xref: FMA:85400 is_obsolete: true created_by: tmeehan creation_date: 2010-09-10T03:30:33Z [Term] id: CL:0002277 name: type I enteroendocrine cell namespace: cell def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [GOC:tfm] synonym: "CCK cell" EXACT [] xref: FMA:62937 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:44:36Z [Term] id: CL:0002278 name: GIP cell namespace: cell def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [GOC:tfm] synonym: "type K enteroendocrine cell" EXACT [] xref: FMA:62942 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:51:47Z [Term] id: CL:0002279 name: type L enteroendocrine cell namespace: cell def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [ISBN:0517223651, PMID:15153415] xref: FMA:62944 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:59:09Z [Term] id: CL:0002280 name: type N enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." [GOC:tfm] synonym: "N cell" EXACT [] xref: FMA:62943 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T04:08:29Z [Term] id: CL:0002281 name: type S enteroendocrine cell namespace: cell def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [GOC:tfm, PMID:15153415] xref: FMA:62936 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000458 ! serotonin secreting cell created_by: tmeehan creation_date: 2010-09-10T04:44:46Z [Term] id: CL:0002282 name: type TG enteroendocrine cell namespace: cell def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [DOI:10.1007/978-3-211-99390-3, GOC:tfm, PMID:7013499] xref: FMA:63421 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000509 ! gastrin secreting cell created_by: tmeehan creation_date: 2010-09-13T09:48:34Z [Term] id: CL:0002283 name: ecto-epithelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000440 def: "An epithelial cell of the mucosa associated with facial skeleton." [GOC:tfm, ISBN:0323052908] xref: FMA:70581 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:04:02Z [Term] id: CL:0002284 name: type X enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." [GOC:tfm, PMID:20616512] synonym: "A-like" EXACT [] synonym: "X/A-like" EXACT [] xref: FMA:63209 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0005018 ! ghrelin secreting cell created_by: tmeehan creation_date: 2010-09-13T10:12:12Z [Term] id: CL:0002285 name: type III taste bud cell namespace: cell def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [GOC:tfm, ISBN:0517223651, PMID:15738192] synonym: "taste bud basal cell" BROAD [] synonym: "type 3 taste cell" EXACT [] xref: FMA:67940 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000209 ! taste receptor cell is_a: CL:1000428 ! stem cell of epidermis created_by: tmeehan creation_date: 2010-09-13T10:57:21Z [Term] id: CL:0002286 name: type II taste cell namespace: cell def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [GOC:tfm, PMID:15738192] synonym: "type 2 taste cell" EXACT [] xref: FMA:62381 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:26Z [Term] id: CL:0002287 name: type IV taste receptor cell namespace: cell def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [GOC:tfm, ISBN:0517223651, PMID:15738192] comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192. synonym: "taste bud basal cell" BROAD [] synonym: "type 4 taste cell" EXACT [] xref: FMA:62380 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:29Z [Term] id: CL:0002288 name: type V taste receptor cell namespace: cell def: "A cell type that forms the boundary with the surrounding epithelium." [GOC:tfm, ISBN:0517223651] xref: FMA:67941 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:31Z [Term] id: CL:0002289 name: type I taste bud cell namespace: cell def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:15738192] synonym: "dark tongue cell" EXACT [] synonym: "type I taste cell" EXACT [] synonym: "type taste 1 cell" EXACT [] xref: FMA:62356 is_a: CL:0000209 ! taste receptor cell is_a: CL:0000703 ! sustentacular cell created_by: tmeehan creation_date: 2010-09-13T10:57:35Z [Term] id: CL:0002290 name: Y chromosome-bearing sperm cell namespace: cell def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "Y bearing sperm" EXACT [] synonym: "Y-bearing sperm" EXACT [] xref: FMA:84058 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:24Z [Term] id: CL:0002291 name: X chromosome-bearing sperm cell namespace: cell def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "X bearing sperm" EXACT [] synonym: "X-bearing sperm" EXACT [] xref: FMA:84057 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:26Z [Term] id: CL:0002292 name: type I cell of carotid body namespace: cell def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651] synonym: "glomus cell" EXACT [] xref: FMA:84186 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-13T01:40:21Z [Term] id: CL:0002293 name: epithelial cell of thymus namespace: cell alt_id: CL:1000459 def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: CALOHA:TS-1040 xref: FMA:72208 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus namespace: cell def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335] synonym: "subcapsular thymic epithelial cell" EXACT [] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [GOC:tfm, PMID:19721455, PMID:9264335] synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus namespace: cell def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [FMA:0412046911, GOC:tfm, PMID:9264335] synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [PMID:9264335] synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [GOC:tfm, ISBN:0412046911, PMID:19721455, PMID:9264335] synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus namespace: cell def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [GOC:tfm, ISBN:0412046911, PMID:9264335] synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus namespace: cell def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [GOC:tfm, PMID:19721455] synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002301 name: type B synovial cell namespace: cell def: "A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." [GOC:tfm, ISBN:0517223651] xref: FMA:66788 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:14Z [Term] id: CL:0002302 name: type A synovial cell namespace: cell def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [GOC:tfm, ISBN:0517223651] synonym: "type A synoviocyte" EXACT [] xref: FMA:66787 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:17Z [Term] id: CL:0002303 name: pigmented ciliary epithelial cell namespace: cell def: "A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells." [PMID:15106942] synonym: "PE" EXACT [] xref: FMA:70606 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:27Z [Term] id: CL:0002304 name: non-pigmented ciliary epithelial cell namespace: cell def: "A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells." [GOC:tfm, PMID:15106942] synonym: "NPE" EXACT [] xref: FMA:70607 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: part_of UBERON:0001778 ! ciliary epithelium relationship: part_of UBERON:0001778 ! ciliary epithelium created_by: tmeehan creation_date: 2010-09-13T04:09:31Z [Term] id: CL:0002305 name: epithelial cell of distal tubule namespace: cell def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651] synonym: "kidney distal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70981 xref: KUPO:0001055 is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004135 ! distal tubule relationship: part_of UBERON:0004135 ! distal tubule [Term] id: CL:0002306 name: epithelial cell of proximal tubule namespace: cell def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3] synonym: "kidney proximal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70973 xref: KUPO:0001044 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004134 ! proximal tubule relationship: part_of UBERON:0004134 ! proximal tubule [Term] id: CL:0002307 name: brush border cell of the proximal tubule namespace: cell def: "A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow." [GOC:tfm, ISBN:1-4160-2328-3] is_a: CL:0002306 ! epithelial cell of proximal tubule created_by: tmeehan creation_date: 2010-09-14T11:29:20Z [Term] id: CL:0002308 name: epithelial cell of skin gland namespace: cell def: "An epithelial cell of a skin gland." [GOC:tfm] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002419 ! skin gland relationship: part_of UBERON:0002419 ! skin gland created_by: tmeehan creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002309 name: corticotroph namespace: cell def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [GOC:tfm, ISBN:0517223651] xref: BTO:0002509 xref: FMA:83098 is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:08:23Z [Term] id: CL:0002310 name: mammosomatotroph namespace: cell def: "An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone." [GOC:tfm] xref: FMA:83097 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:25:34Z [Term] id: CL:0002311 name: mammotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl] synonym: "epsilon-acidophil" EXACT [] synonym: "lactotrope" EXACT [] synonym: "lactotroph" EXACT [] synonym: "lactotropic cell" EXACT [] synonym: "mammotrope" EXACT [] synonym: "mammotrophic cell" EXACT [] synonym: "mammotropic cell" EXACT [] xref: FMA:83096 is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:30:57Z [Term] id: CL:0002312 name: somatotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] synonym: "somatotrope" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland namespace: cell def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm] synonym: "glandular cell of prostate" EXACT [] synonym: "neuro-epithelial cell of prostate gland" EXACT [] xref: CALOHA:TS-1280 xref: FMA:74390 xref: FMA:86774 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T03:01:58Z [Term] id: CL:0002314 name: external supporting cell of vestibular epithelium namespace: cell def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [GOC:tfm, PMID:20837532] xref: FMA:75809 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:20:01Z [Term] id: CL:0002315 name: supporting cell of cochlea namespace: cell def: "An epithelial supporting cell located in the cochlea." [GOC:tfm] xref: FMA:79796 is_a: CL:0001035 ! bone cell is_a: CL:0005014 ! auditory epithelial support cell intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0001844 ! cochlea relationship: part_of UBERON:0001844 ! cochlea created_by: tmeehan creation_date: 2010-09-14T03:31:38Z [Term] id: CL:0002316 name: supporting cell of vestibular epithelium namespace: cell def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532] xref: FMA:75607 is_a: CL:0005014 ! auditory epithelial support cell intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0001862 ! vestibular labyrinth relationship: part_of UBERON:0001862 ! vestibular labyrinth created_by: tmeehan creation_date: 2010-09-14T03:31:44Z [Term] id: CL:0002317 name: external limiting cell of vestibular epithelium namespace: cell def: "An external limiting cell found in the vestibular epithelium." [GOC:tfm] xref: FMA:75808 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:33:50Z [Term] id: CL:0002318 name: periperhal blood mesothelial cell namespace: cell def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528] xref: FMA:86712 is_a: CL:0000081 ! blood cell relationship: develops_from CL:0000077 ! mesothelial cell created_by: tmeehan creation_date: 2010-09-15T10:47:11Z [Term] id: CL:0002319 name: neural cell namespace: cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system created_by: tmeehan creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell namespace: cell alt_id: CL:1000406 def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2096 xref: FMA:63875 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue created_by: tmeehan creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell namespace: cell def: "A cell of the embryo." [FMA:0618947256] xref: CALOHA:TS-0263 xref: FMA:82840 xref: FMA:82841 xref: WBbt:0007028 is_a: CL:0000548 ! animal cell created_by: tmeehan creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002322 name: embryonic stem cell namespace: cell def: "A stem cell of embryonic origin." [GOC:dsd, GOC:tfm, ISBN:068340007X, PMID:18179856] comment: This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive. synonym: "ESC" EXACT [] xref: BTO:0001086 xref: CALOHA:TS-0263 xref: FMA:82841 is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell created_by: tmeehan creation_date: 2010-09-15T03:44:35Z [Term] id: CL:0002323 name: amniocyte namespace: cell def: "A cell of afetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847] xref: BTO:0000066 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: located_in UBERON:0000173 ! amniotic fluid relationship: located_in UBERON:0000173 ! amniotic fluid created_by: tmeehan creation_date: 2010-09-20T10:13:37Z [Term] id: CL:0002324 name: myoepithelial cell of mammary gland namespace: cell def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [GOC:tfm, PMID:11250738, PMID:19022771] is_a: CL:1000416 ! myoepithelial cell of lactiferous gland created_by: tmeehan creation_date: 2010-09-20T11:42:14Z [Term] id: CL:0002325 name: mammary alveolar cell namespace: cell alt_id: CL:0002230 alt_id: CL:1000476 def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771] synonym: "epithelial cell of lactiferous gland" EXACT [] synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] xref: FMA:74506 xref: FMA:79866 is_a: CL:0000314 ! milk secreting cell is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell is_a: CL:1001586 ! mammary gland glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0003214 ! mammary gland alveolus relationship: part_of UBERON:0003214 ! mammary gland alveolus created_by: tmeehan creation_date: 2010-09-20T01:30:57Z [Term] id: CL:0002326 name: luminal epithelial cell of mammary gland namespace: cell def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771] xref: FMA:73280 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:37:53Z [Term] id: CL:0002327 name: mammary gland epithelial cell namespace: cell def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771] synonym: "breast epithelial cell" EXACT [] synonym: "mammary epithelial cell" EXACT [] xref: BTO:0004300 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2010-09-20T01:49:37Z [Term] id: CL:0002328 name: bronchial epithelial cell namespace: cell def: "An epithelial cell of the bronchus." [GOC:tfm] xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree namespace: cell def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:10:36Z [Term] id: CL:0002330 name: undifferentiated cell of bronchus epithelium namespace: cell def: "An undifferentiated columnar cell of the bronchus epithelium" [GOC:tfm, PMID:18757316] is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-20T02:17:58Z [Term] id: CL:0002332 name: ciliated cell of the bronchus namespace: cell def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:21:12Z [Term] id: CL:0002333 name: neural crest derived fat cell namespace: cell def: "A fat cell derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000005 ! fibroblast neural crest derived relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte namespace: cell def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119] xref: BTO:0001107 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte namespace: cell def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2010-09-20T02:38:38Z [Term] id: CL:0002336 name: buccal mucosa cell namespace: cell def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:A10.615.550.599] is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2010-09-20T02:52:54Z [Term] id: CL:0002337 name: keratinocyte stem cell namespace: cell def: "A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair." [PMID:15339667] synonym: "bulge keratinocyte" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000312 ! keratinocyte is_a: CL:1000428 ! stem cell of epidermis created_by: tmeehan creation_date: 2010-09-20T03:07:03Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002339 name: prostate stem cell namespace: cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377] synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-20T03:21:06Z [Term] id: CL:0002340 name: luminal cell of prostate epithelium namespace: cell def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [GOC:tfm] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:05Z [Term] id: CL:0002341 name: basal cell of prostate epithelium namespace: cell def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:10Z [Term] id: CL:0002342 name: circulating endothelial cell namespace: cell def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [GOC:tfm, PMID:19652886] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-20T03:49:58Z [Term] id: CL:0002343 name: decidual natural killer cell namespace: cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000009766 ! galectin-1 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000009766 ! galectin-1 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 created_by: tmeehan creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422] comment: Markers are associated with mouse cells. synonym: "preNK.BM" BROAD [] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: has_plasma_membrane_part PR:000001008 ! integrin alpha-2 intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48 relationship: develops_from CL:0002346 ! Dx5-negative, NK1.1-positive immature natural killer cell relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48 created_by: tmeehan creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 created_by: tmeehan creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell namespace: cell def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0002349 ! CD27-high, CD11b-low natural killer cell relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production created_by: tmeehan creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell namespace: cell def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: develops_from CL:0002347 ! CD27-high, CD11b-high natural killer cell relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell namespace: cell def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: develops_from CL:0002345 ! CD27-low, CD11b-low immature natural killer cell relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002350 name: endocardial cell namespace: cell alt_id: CL:1000475 def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium created_by: tmeehan creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas namespace: cell def: "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494] synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell namespace: cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764] is_a: CL:0002195 ! hepatic stem cell is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: has_plasma_membrane_part GO:0042611 ! MHC protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: has_plasma_membrane_part GO:0042611 ! MHC protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell namespace: cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: part_of UBERON:0001040 ! yolk sac created_by: tmeehan creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell namespace: cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: has_part PR:000008467 ! hemoglobin subunit zeta intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1 intersection_of: part_of UBERON:0000922 ! embryo relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002361 ! primitive erythroid progenitor relationship: has_part PR:000008467 ! hemoglobin subunit zeta relationship: has_part PR:000008857 ! hemoglobin subunit beta-1 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002356 name: primitive reticulocyte namespace: cell def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "megalocyte" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: develops_from CL:0002355 ! primitive red blood cell relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T09:35:16Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte namespace: cell def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698] synonym: "macrocyte" EXACT [] is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1 intersection_of: part_of UBERON:0000922 ! embryo relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor cell relationship: has_part PR:000008857 ! hemoglobin subunit beta-1 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:38:32Z [Term] id: CL:0002358 name: pyrenocyte namespace: cell def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [GOC:tfm] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000587 ! decreased size intersection_of: develops_from CL:0002355 ! primitive red blood cell relationship: bearer_of PATO:0000587 ! decreased size relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T10:02:37Z [Term] id: CL:0002359 name: placental hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2010-09-22T10:30:02Z [Term] id: CL:0002360 name: AGM hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:31:49Z [Term] id: CL:0002361 name: primitive erythroid progenitor namespace: cell def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002418 ! hemangioblast relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-09-22T10:47:28Z [Term] id: CL:0002362 name: granule cell precursor namespace: cell def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [GOC:tfm, PMID:14745007] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) created_by: tmeehan creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte namespace: cell def: "A keratocyte is a specialized fibroblastresiding in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. Thiscorneallayer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5] synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! fibroblast neural crest derived intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001777 ! substantia propria of cornea created_by: tmeehan creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002364 name: cortical thymic epithelial cell namespace: cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190] synonym: "cTEC" EXACT [] xref: BTO:0004562 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell namespace: cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458] synonym: "mTEC" EXACT [] xref: BTO:0004563 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002366 name: myometrial cell namespace: cell def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640] synonym: "myometrium smooth muscle cell" EXACT [] xref: BTO:0004519 is_a: CL:0002601 ! uterine smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001296 ! myometrium relationship: part_of UBERON:0001296 ! myometrium created_by: tmeehan creation_date: 2010-09-23T03:46:34Z [Term] id: CL:0002367 name: trabecular meshwork cell namespace: cell def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [GOC:tfm, PMID:14500801] synonym: "trabeculocyte" EXACT [] is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0005969 ! reticulum trabeculare relationship: part_of UBERON:0005969 ! reticulum trabeculare created_by: tmeehan creation_date: 2010-09-23T04:18:50Z [Term] id: CL:0002368 name: respiratory epithelial cell namespace: cell def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] synonym: "airway epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract created_by: tmeehan creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore namespace: cell def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002370 name: respiratory goblet cell namespace: cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544] synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863] is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0004802 ! respiratory tract epithelium created_by: tmeehan creation_date: 2010-09-23T04:42:27Z [Term] id: CL:0002371 name: somatic cell namespace: cell def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544] subset: ubprop:upper_level xref: BTO:0001268 xref: FMA:72300 xref: WBbt:0008378 is_a: CL:0000003 ! native cell created_by: tmeehan creation_date: 2010-09-24T09:44:42Z [Term] id: CL:0002372 name: myotube namespace: cell alt_id: CL:0000369 def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] synonym: "myotubule" EXACT [] synonym: "single cell sarcomere" EXACT [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: has_part GO:0030017 ! sarcomere created_by: tmeehan creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002373 name: growth hormone releasing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [GOC:dph, GOC:tfm] synonym: "GHRH secreting cell" EXACT [] synonym: "somatocrinin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-24T01:36:44Z [Term] id: CL:0002374 name: ear hair cell namespace: cell def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023] synonym: "ear receptor cell" EXACT [] is_a: CL:0000855 ! sensory hair cell created_by: tmeehan creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor namespace: cell def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm] synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0000030 ! glioblast relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002376 name: non-myelinating Schwann cell namespace: cell def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell created_by: tmeehan creation_date: 2010-09-24T02:10:26Z [Term] id: CL:0002377 name: immature Schwann cell namespace: cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] xref: ZFA:0001725 is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002375 ! Schwann cell precursor created_by: tmeehan creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002379 name: meningothelial cell namespace: cell def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [GOC:tfm, http://www.aippg.net/forum/viewtopic.php?t=62590] synonym: "arachnoid cap cell" EXACT [] xref: FMA:86588 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-28T02:23:46Z [Term] id: CL:0002380 name: oospore namespace: cell def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [GOC:tfm, ISBN:0851988857, SGD:clt] xref: FAO:0000039 is_a: CL:0000605 ! fungal asexual spore created_by: tmeehan creation_date: 2010-10-01T09:22:45Z [Term] id: CL:0002381 name: uninucleate conidium namespace: cell def: "A conidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000025 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:26:39Z [Term] id: CL:0002382 name: multinucleate conidium namespace: cell def: "A conidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000033 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:31:28Z [Term] id: CL:0002383 name: conidium of conidiophore head namespace: cell def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [GOC:tfm, PMID:9529886, SGD:clt] xref: FAO:0000033 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002384 name: uninucleate macroconidium namespace: cell def: "A macroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000029 is_a: CL:0000606 ! macroconidium is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002385 name: blastoconidium namespace: cell def: "An oblong or round asexual spore formed from conidial chains." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "blastospore" RELATED [] xref: BTO:0000127 xref: FAO:0000042 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002386 name: multinucleate macroconidium namespace: cell def: "A macroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000035 is_a: CL:0000606 ! macroconidium is_a: CL:0002382 ! multinucleate conidium [Term] id: CL:0002387 name: arthroconidium namespace: cell def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "arthrospore" RELATED [] xref: FAO:0000041 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002388 name: multinucleate arthroconidium namespace: cell def: "An arthroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000037 is_a: CL:0002386 ! multinucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002389 name: uninucleate arthroconidium namespace: cell def: "An arthroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000031 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002390 name: uninucleate blastconidium namespace: cell def: "A blastoconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000030 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002385 ! blastoconidium [Term] id: CL:0002391 name: multinucleate blastoconidium namespace: cell def: "A blastoconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000036 is_a: CL:0002385 ! blastoconidium is_a: CL:0002386 ! multinucleate macroconidium [Term] id: CL:0002392 name: obsolete plant spore namespace: cell def: "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." [GOC:tfm, PO:0025017] comment: replaced_by: PO:0025017 is_obsolete: true [Term] id: CL:0002393 name: intermediate monocyte namespace: cell def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_not_completed GO:0030224 ! monocyte differentiation intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: develops_from CL:0000860 ! classical monocyte relationship: has_not_completed GO:0030224 ! monocyte differentiation relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 created_by: tmeehan creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [GOC:dsd, GOC:tfm, PMCID:PMC2882828, PMCID:PMC2882837, PMID:17332250, PMID:20628149] comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs. is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000002105 ! thrombomodulin intersection_of: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032606 ! capable_of type I interferon production intersection_of: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: has_plasma_membrane_part PR:000002105 ! thrombomodulin relationship: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032606 ! capable_of type I interferon production relationship: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I created_by: tmeehan creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:20628149, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin created_by: tmeehan creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte namespace: cell def: "A patrolling monocyte that is CD14-low and CD16-positive." [GOC:tfm, PMID:20870168] comment: Markers are associated with human monocytes. synonym: "non-classical monocyte, human" EXACT [] is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0002397 ! CD14-positive, CD16-positive monocyte relationship: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte namespace: cell def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). synonym: "CD16+ monocyte" EXACT [PMID:22343568] is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 created_by: tmeehan creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte namespace: cell def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: develops_from CL:0002395 ! Gr1-high classical monocyte relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 created_by: tmeehan creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD1c-positive." [GOC:dsd, GOC:tfm, PMID:20204387, PMID:20628149] comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c intersection_of: RO:0002215 GO:0032637 ! capable_of interleukin-8 production relationship: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c relationship: RO:0002215 GO:0032637 ! capable_of interleukin-8 production created_by: tmeehan creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: Fraction B/C precursor B cell namespace: cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex created_by: tmeehan creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002218 ! immature dendritic epithelial T cell precursor created_by: tmeehan creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell namespace: cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: part_of UBERON:0001211 ! Peyer's patch created_by: tmeehan creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002378 ! immature Vgamma2-positive fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte namespace: cell def: "A thymocyte found in the fetal thymus." [GOC:tfm] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte namespace: cell def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [GOC:tfm, PMID:20725107] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 created_by: tmeehan creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002406 ! immature Vgamma2-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002408 ! immature Vgamma2-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002410 name: pancreatic stellate cell namespace: cell def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [GOC:mah, GOC:tfm, PMID:17200706] synonym: "PaSC" EXACT [] is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2010-11-10T09:40:33Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org] synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002417 name: primitive erythroid lineage cell namespace: cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm] is_a: CL:0000764 ! erythroid lineage cell created_by: tmeehan creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast namespace: cell def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698] is_a: CL:0000222 ! mesodermal cell relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell created_by: tmeehan creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell namespace: cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_completed GO:0045058 ! T cell selection intersection_of: has_plasma_membrane_part GO:0042101 ! T cell receptor complex relationship: has_completed GO:0045058 ! T cell selection relationship: has_plasma_membrane_part GO:0042101 ! T cell receptor complex created_by: tmeehan creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell namespace: cell def: "A T cell that has not completed T cell selection." [GOC:tfm] synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: has_not_completed GO:0045058 ! T cell selection created_by: tmeehan creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002421 name: nucleated reticulocyte namespace: cell def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 {is_inferred="true"} ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte namespace: cell def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464] xref: CALOHA:TS-0864 xref: FMA:66785 is_a: CL:0000225 ! anucleate cell is_a: CL:0000558 {is_inferred="true"} ! reticulocyte intersection_of: CL:0000558 ! reticulocyte intersection_of: bearer_of PATO:0001405 ! anucleate intersection_of: has_part GO:0005840 ! ribosome relationship: bearer_of PATO:0001405 ! anucleate relationship: has_part GO:0005840 ! ribosome created_by: tmeehan creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002423 name: DN2a thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-hi." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-low." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: develops_from CL:0002423 ! DN2a thymocyte relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002425 name: early T lineage precursor namespace: cell def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:16551251] comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha created_by: tmeehan creation_date: 2010-10-21T01:16:24Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell namespace: cell def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [GOC:tfm, http://www.immgen.org/index_content.html] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte namespace: cell def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: bearer_of PATO:0000587 ! decreased size relationship: bearer_of PATO:0000587 ! decreased size created_by: tmeehan creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast namespace: cell def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: participates_in GO:0008283 ! cell proliferation relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002427 ! resting double-positive thymocyte relationship: participates_in GO:0008283 ! cell proliferation created_by: tmeehan creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002428 ! double-positive blast relationship: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule created_by: tmeehan creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte namespace: cell def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule created_by: tmeehan creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte namespace: cell def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte namespace: cell def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http:www.immgen.org/index_content.html] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell namespace: cell def: "A mature NK cell that is NK1.1-positive." [GOC:tfm] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C created_by: tmeehan creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is NKGA2-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein relationship: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein created_by: tmeehan creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 relationship: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 created_by: tmeehan creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 created_by: tmeehan creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0002446 ! Ly49CI-negative natural killer cell is_a: CL:0002447 ! CD94-negative natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 relationship: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 created_by: tmeehan creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 relationship: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 created_by: tmeehan creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 created_by: tmeehan creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 relationship: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 created_by: tmeehan creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002441 ! CD94-positive natural killer cell is_a: CL:0002443 ! Ly49CI-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0002450 name: tether cell namespace: cell def: "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." [GOC:cvs, GOC:tfm, PMID:9398434] is_a: CL:0002374 ! ear hair cell created_by: tmeehan creation_date: 2010-11-10T01:41:00Z [Term] id: CL:0002451 name: mammary stem cell namespace: cell def: "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." [GOC:hjd, GOC:tfm, PMID:15987436, PMID:16397499, PMID:17851544] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-11-10T01:46:51Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell namespace: cell def: "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:20142420] is_a: CL:0000123 {is_inferred="true"} ! neuron associated cell (sensu Vertebrata) intersection_of: CL:0000123 ! neuron associated cell (sensu Vertebrata) intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell namespace: cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002455 name: CD8_alpha-negative plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:27:37Z [Term] id: CL:0002456 name: CD8_alpha-positive plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:23:07Z [Term] id: CL:0002457 name: epidermal Langerhans cell namespace: cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: part_of UBERON:0001003 ! epidermis relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: part_of UBERON:0001003 ! epidermis created_by: tmeehan creation_date: 2010-11-22T03:57:57Z [Term] id: CL:0002458 name: langerin-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-11-22T04:06:22Z [Term] id: CL:0002459 name: langerin-negative dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell relationship: lacks_plasma_membrane_part CL:0002507 ! langerin-positive lymph node dendritic cell relationship: lacks_plasma_membrane_part CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-22T04:09:44Z [Term] id: CL:0002460 name: CD8alpha-negative thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-23T10:58:53Z [Term] id: CL:0002461 name: CD103-positive dendritic cell namespace: cell def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-23T01:32:43Z [Term] id: CL:0002462 name: adipose dendritic cell namespace: cell def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell namespace: cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002466 name: small intestine serosal dendritic cell namespace: cell def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.11cloSer.SI" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-23T02:00:21Z [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T02:15:12Z [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T02:19:43Z [Term] id: CL:0002469 name: MHC-II-negative classical monocyte namespace: cell def: "Gr1-high monocyte that lacks MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:27:12Z [Term] id: CL:0002470 name: MHC-II-positive classical monocyte namespace: cell def: "Gr1-high monocyte that has a MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:30:21Z [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:38:15Z [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:47:53Z [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:47:55Z [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002469 {is_inferred="true"} ! MHC-II-negative classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T04:00:52Z [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002469 ! MHC-II-negative classical monocyte is_a: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 created_by: tmeehan creation_date: 2010-11-23T04:09:09Z [Term] id: CL:0002476 name: bone marrow macrophage namespace: cell def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.BM" RELATED [] xref: BTO:0004732 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-11-23T04:19:25Z [Term] id: CL:0002477 name: adipose macrophage namespace: cell def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage namespace: cell def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 created_by: tmeehan creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage namespace: cell def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002480 name: nasal mucosa goblet cell namespace: cell def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm] xref: MP:0002262 is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa relationship: part_of UBERON:0001826 ! nasal cavity mucosa relationship: part_of UBERON:0005384 ! nasal cavity epithelium created_by: tmeehan creation_date: 2010-12-03T03:03:02Z [Term] id: CL:0002481 name: peritubular myoid cell namespace: cell def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420] is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis created_by: tmeehan creation_date: 2010-12-03T03:11:48Z [Term] id: CL:0002482 name: dermal melanocyte namespace: cell def: "A melanocyte that produces pigment in the dermis." [GOC:cjm, GOC:tfm, MP:0009386] is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2010-12-03T03:17:05Z [Term] id: CL:0002483 name: hair follicle melanocyte namespace: cell def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381] is_a: CL:0002559 ! hair follicle cell is_a: CL:2000000 ! epidermal melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2010-12-03T03:17:09Z [Term] id: CL:0002484 name: epithelial melanocyte namespace: cell def: "A melanocyte that produces pigment in the epithelium." [GOC:tfm, MP:0009388] is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000483 ! epithelium relationship: part_of UBERON:0000483 ! epithelium created_by: tmeehan creation_date: 2010-12-03T03:17:14Z [Term] id: CL:0002485 name: retinal melanocyte namespace: cell def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [GOC:tfm, MP:0010190] is_a: CL:0000148 {is_inferred="true"} ! melanocyte is_a: CL:0009004 ! retinal cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2010-12-03T03:25:32Z [Term] id: CL:0002486 name: strial intermediate cell namespace: cell def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048] is_a: CL:0000148 {is_inferred="true"} ! melanocyte is_a: CL:0002491 ! auditory epithelial cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-03T03:29:15Z [Term] id: CL:0002487 name: cutaneous/subcutaneous mechanoreceptor cell namespace: cell def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [GOC:tfm, MP:0000973] is_a: CL:0000199 ! mechanoreceptor cell created_by: tmeehan creation_date: 2010-12-06T02:53:30Z [Term] id: CL:0002488 name: trophoblast giant cell namespace: cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [GOC:tfm, MP:0001714, MP:19876834] synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 {is_inferred="true"} ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: RO:0002215 GO:0001974 ! capable_of blood vessel remodeling relationship: bearer_of PATO:0000586 ! increased size relationship: RO:0002215 GO:0001974 ! capable_of blood vessel remodeling created_by: tmeehan creation_date: 2010-12-06T02:55:24Z [Term] id: CL:0002489 name: double negative thymocyte namespace: cell def: "A thymocyte that lacks expression of CD4 and CD8." [GOC:tfm, MP:0002407] synonym: "double negative T cell" BROAD [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 created_by: tmeehan creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002490 name: organ of Corti supporting cell namespace: cell def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300] is_a: CL:0002315 ! supporting cell of cochlea intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea relationship: part_of UBERON:0002227 ! spiral organ of cochlea created_by: tmeehan creation_date: 2010-12-06T03:09:01Z [Term] id: CL:0002491 name: auditory epithelial cell namespace: cell def: "A specialized cell involved in auditory sensory perception." [GOC:tfm] is_a: CL:0000098 ! sensory epithelial cell created_by: tmeehan creation_date: 2010-12-06T03:18:43Z [Term] id: CL:0002492 name: strial marginal cell namespace: cell def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [GOC:tfm, MP:0004366] is_a: CL:0002491 ! auditory epithelial cell created_by: tmeehan creation_date: 2010-12-06T03:20:41Z [Term] id: CL:0002493 name: strial basal cell namespace: cell def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [GOC:tfm, MP:0004365] comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] is_a: CL:0002491 ! auditory epithelial cell relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-06T03:26:53Z [Term] id: CL:0002494 name: cardiocyte namespace: cell def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0007100 ! circulatory organ relationship: part_of UBERON:0007100 ! circulatory organ created_by: tmeehan creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002495 name: fetal cardiomyocyte namespace: cell def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [GOC:tfm, MP:0008788] synonym: "embryonic cardiomyocyte" EXACT [] synonym: "neonatal cardiomyocyte" EXACT [] is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-12-07T09:50:41Z [Term] id: CL:0002496 name: intraepithelial lymphocyte namespace: cell def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [GOC:tfm, MP:0008894] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response created_by: tmeehan creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002497 name: primary trophoblast giant cell namespace: cell def: "A trophoblast giant cell derived from the mural trophectoderm." [GOC:tfm, PMCID:PMC85124] xref: EMAPA:16066 is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:47Z [Term] id: CL:0002498 name: secondary trophoblast giant cell namespace: cell def: "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." [GOC:tfm, PMCID:PMC85124] is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:52Z [Term] id: CL:0002499 name: spongiotrophoblast cell namespace: cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-12-07T12:56:56Z [Term] id: CL:0002500 name: P enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." [FMA:63418, GOC:tfm] is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:06Z [Term] id: CL:0002501 name: type D1 enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." [FMA:63207, GOC:tfm] xref: FMA:63207 is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:09Z [Term] id: CL:0002502 name: type M enteroendocrine cell namespace: cell def: "An enteroendocrine cell of the small intestine that secretes motilin." [GOC:tfm, PMID:15153415] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:63420 is_a: CL:0002272 ! motilin secreting cell is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine glandular cell relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-12-07T03:55:49Z [Term] id: CL:0002503 name: adventitial cell namespace: cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0005742 ! adventitia relationship: part_of UBERON:0005742 ! adventitia created_by: tmeehan creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell namespace: cell def: "A smooth muscle cell of the intestine." [GOC:tfm] synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002505 name: liver CD103-negative dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [GOC:tfm, http:http\://www.immgen.org/index_content.html] synonym: "DC.103-11b+.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: part_of UBERON:0001281 ! hepatic sinusoid created_by: tmeehan creation_date: 2011-01-21T01:27:41Z [Term] id: CL:0002506 name: liver CD103-positive dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [GOC:tfm, http:http\://www.immgen.org/index_content.html] synonym: "DC.103+11b-.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: part_of UBERON:0001281 ! hepatic sinusoid created_by: tmeehan creation_date: 2011-01-21T01:27:45Z [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2011-01-21T01:57:00Z [Term] id: CL:0002508 name: langerin-negative, CD103-negative lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K created_by: tmeehan creation_date: 2011-01-21T02:13:58Z [Term] id: CL:0002509 name: CD103-positive, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2011-01-21T02:07:54Z [Term] id: CL:0002510 name: CD103-negative, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2011-01-21T02:11:14Z [Term] id: CL:0002511 name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2011-01-21T02:22:15Z [Term] id: CL:0002512 name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2011-01-21T02:16:21Z [Term] id: CL:0002513 name: Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "tgd.vg5+.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:22:18Z [Term] id: CL:0002514 name: Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "tgd.vg5-.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:25:44Z [Term] id: CL:0002515 name: interrenal norepinephrine type cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." [GOC:MH, GOC:tfm, PMID:12668625] synonym: "interrenal noradrenaline type cell" EXACT [] synonym: "type n interrenal cell" EXACT [] is_a: CL:0000459 ! norepinephrin secreting cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:11:55Z [Term] id: CL:0002516 name: interrenal chromaffin cell namespace: cell def: "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." [GOC:MH, GOC:tfm, PMID:12668625] is_a: CL:0000166 ! chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:21:35Z [Term] id: CL:0002517 name: interrenal epinephrin secreting cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." [GOC:MH, GOC:tfm, PMID:12668625] synonym: "interrenal adrenaline secreting cell" RELATED [] synonym: "type a interrenal cell" EXACT [] is_a: CL:0000454 ! epinephrine secreting cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:27:05Z [Term] id: CL:0002518 name: kidney epithelial cell namespace: cell def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ] xref: KUPO:0001019 is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney created_by: tmeehan creation_date: 2011-02-08T10:46:34Z [Term] id: CL:0002519 name: interrenal epithelial cell namespace: cell def: "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." [GOC:mh, GOC:tfm, PMID:12668625] is_a: CL:0002518 ! kidney epithelial cell created_by: tmeehan creation_date: 2011-02-08T11:03:32Z [Term] id: CL:0002520 name: nephrocyte namespace: cell def: "An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis." [GOC:tfm, PMID:19783135] xref: BTO:0004597 xref: FMA:83807 is_a: CL:0002522 ! renal filtration cell created_by: tmeehan creation_date: 2011-02-08T01:34:56Z [Term] id: CL:0002521 name: subcutaneous fat cell namespace: cell def: "A fat cell that is part of subcutaneous adipose tissue." [GOC:tfm] synonym: "subcutaneous adipocyte" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue created_by: tmeehan creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002522 name: renal filtration cell namespace: cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm] is_a: CL:0000424 ! excretory cell relationship: part_of UBERON:0001008 ! renal system created_by: tmeehan creation_date: 2011-02-08T01:37:59Z [Term] id: CL:0002523 name: mesonephric glomerular visceral epithelial cell namespace: cell def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros" [GOC:tfm] is_a: CL:0000653 ! glomerular visceral epithelial cell created_by: tmeehan creation_date: 2011-02-08T01:58:30Z [Term] id: CL:0002524 name: disseminated nephrocyte namespace: cell def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [GOC:tfm, PMID:19783135] is_a: CL:0002520 ! nephrocyte created_by: tmeehan creation_date: 2011-02-08T02:07:33Z [Term] id: CL:0002525 name: metanephric glomerular visceral epithelial cell namespace: cell def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:tfm] is_a: CL:0000653 ! glomerular visceral epithelial cell created_by: tmeehan creation_date: 2011-02-08T02:02:13Z [Term] id: CL:0002526 name: CD14-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [GOC:dsd, PMID:19236899, PMID:20309010] comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. synonym: "CD14+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a intersection_of: RO:0002215 GO:0045191 ! capable_of regulation of isotype switching relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: RO:0002215 GO:0045191 ! capable_of regulation of isotype switching [Term] id: CL:0002527 name: immature CD14-positive dermal dendritic cell namespace: cell def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002528 name: mature CD14-positive dermal dendritic cell namespace: cell def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GOC:dsd] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002527 ! immature CD14-positive dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002529 name: CD1a-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [GOC:dsd, PMID:20309010] comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. synonym: "CD1a+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0002530 name: immature CD1a-positive dermal dendritic cell namespace: cell def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002531 name: mature CD1a-positive dermal dendritic cell namespace: cell def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002530 ! immature CD1a-positive dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [GOC:dsd, PMID:17332250] comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell namespace: cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell namespace: cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002533 ! immature CD16-positive myeloid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002535 name: epithelial cell of cervix namespace: cell def: "An epithelial cell of the cervix." [GOC:tfm] synonym: "cervical canal epithelial cell" EXACT [GOC:tfm] synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm] synonym: "cervix epithelial cell" EXACT [GOC:tfm] synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm] synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm] synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium created_by: tmeehan creation_date: 2011-02-24T08:20:08Z [Term] id: CL:0002536 name: amniotic epithelial cell namespace: cell def: "An epithelial cell that is part of the amnion." [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:38:01Z [Term] id: CL:0002537 name: amnion mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039] synonym: "amniotic membrane stem cell" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:44:24Z [Term] id: CL:0002538 name: intrahepatic bile duct epithelial cell namespace: cell def: "An epithelial cell of the intrahepatic portion of the bile duct." [GOC:tfm] is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell is_a: CL:0000182 ! hepatocyte intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium created_by: tmeehan creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell namespace: cell def: "A smooth muscle cell of the aorta." [GOC:tfm] xref: BTO:0004577 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue created_by: tmeehan creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow namespace: cell def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002541 name: chorionic membrane mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0003124 ! chorion relationship: part_of UBERON:0003124 ! chorion created_by: tmeehan creation_date: 2011-02-28T03:04:35Z [Term] id: CL:0002543 name: vein endothelial cell namespace: cell alt_id: CL:1000393 def: "An endothelial cell that is part of the vein." [GOC:tfm] synonym: "endothelial cell of vein" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein created_by: tmeehan creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002544 name: aortic endothelial cell namespace: cell def: "An arterial endothelial cell that is part of the aorta endothelium." [GOC:tfm] xref: BTO:0003245 xref: CALOHA:TS-0047 is_a: CL:1000413 ! endothelial cell of artery created_by: tmeehan creation_date: 2011-02-28T03:54:42Z [Term] id: CL:0002545 name: thoracic aorta endothelial cell namespace: cell def: "An endothelial cell that is part of the thoracic endothelium." [GOC:tfm] is_a: CL:0002544 {is_inferred="true"} ! aortic endothelial cell intersection_of: CL:0002544 ! aortic endothelial cell intersection_of: part_of UBERON:0001515 ! thoracic aorta relationship: part_of UBERON:0001515 ! thoracic aorta created_by: tmeehan creation_date: 2011-02-28T03:59:09Z [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell namespace: cell def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] comment: See CL:0002619. is_a: CL:0000222 ! mesodermal cell is_a: CL:0002371 ! somatic cell created_by: tmeehan creation_date: 2011-02-28T04:20:39Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia namespace: cell def: "A fibroblast of the aortic adventitia." [GOC:tfm] is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia relationship: part_of UBERON:0004664 ! aorta tunica adventitia created_by: tmeehan creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: cardiac fibroblast namespace: cell def: "A fibroblast that is part of the heart." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002494 {is_inferred="true"} ! cardiocyte intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart created_by: tmeehan creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002549 name: fibroblast of choroid plexus namespace: cell def: "A fibroblast that is part of the choroid plexus." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002319 ! neural cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus created_by: tmeehan creation_date: 2011-02-28T05:01:39Z [Term] id: CL:0002550 name: fibroblast of the conjuctiva namespace: cell def: "A fibroblast that is part of the conjuctiva of the eye." [GOC:tfm] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva created_by: tmeehan creation_date: 2011-02-28T05:03:44Z [Term] id: CL:0002551 name: fibroblast of dermis namespace: cell is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002552 name: fibroblast of gingiva namespace: cell is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001828 ! gingiva relationship: part_of UBERON:0001828 ! gingiva created_by: tmeehan creation_date: 2011-02-28T05:09:12Z [Term] id: CL:0002553 name: fibroblast of lung namespace: cell def: "A fibroblast that is part of lung." [GOC:tfm] xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung created_by: tmeehan creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002554 name: fibroblast of lymphatic vessel namespace: cell def: "A fibroblast of the lymphatic system." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2011-02-28T05:16:18Z [Term] id: CL:0002555 name: fibroblast of mammary gland namespace: cell def: "A fibroblast that is part of the mammary gland." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2011-02-28T05:18:38Z [Term] id: CL:0002556 name: fibroblast of periodontium namespace: cell def: "A fibroblast of the periodontium." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001758 ! periodontium relationship: part_of UBERON:0001758 ! periodontium created_by: tmeehan creation_date: 2011-02-28T05:19:48Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery namespace: cell def: "A fibroblast of pulmonary artery." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002558 name: fibroblast of villous mesenchyme namespace: cell def: "A fibroblast that is part of villous mesenchyme." [GOC:tfm] is_a: CL:0000057 ! fibroblast is_a: CL:0000349 ! extraembryonic cell relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2011-02-28T05:24:28Z [Term] id: CL:0002559 name: hair follicle cell namespace: cell def: "An animal cell that is part of a hair follicle." [GOC:tfm] is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2011-03-01T04:11:01Z [Term] id: CL:0002560 name: inner root sheath cell namespace: cell def: "An epithelial cell that resides in the inner root sheath of the hair follicle." [GOC:tfm] is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell intersection_of: CL:0002559 ! hair follicle cell intersection_of: part_of UBERON:0005941 ! hair inner root sheath relationship: part_of UBERON:0005941 ! hair inner root sheath created_by: tmeehan creation_date: 2011-03-01T04:27:51Z [Term] id: CL:0002561 name: outer root sheath cell namespace: cell def: "An epithelial cell that is part of the outer root sheath." [GOC:tfm] is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005942 ! hair outer root sheath relationship: part_of UBERON:0005942 ! hair outer root sheath created_by: tmeehan creation_date: 2011-03-01T04:29:47Z [Term] id: CL:0002562 name: hair germinal matrix cell namespace: cell def: "An epidermal cell that is part of the germinal matrix." [GOC:tfm] synonym: "trichocyte" EXACT [] is_a: CL:0000362 {is_inferred="true"} ! epidermal cell is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000362 ! epidermal cell intersection_of: part_of UBERON:0006004 ! hair follicle matrix region relationship: part_of UBERON:0006004 ! hair follicle matrix region created_by: tmeehan creation_date: 2011-03-01T04:31:06Z [Term] id: CL:0002563 name: intestinal epithelial cell namespace: cell def: "An epithelial cell of the intestine." [GOC:tfm] is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001277 ! intestinal epithelium created_by: tmeehan creation_date: 2011-03-01T05:18:31Z [Term] id: CL:0002564 name: nucleus pulposus cell of intervertebral disc namespace: cell def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [GOC:tfm] is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002242 ! nucleus pulposus relationship: part_of UBERON:0002242 ! nucleus pulposus created_by: tmeehan creation_date: 2011-03-02T02:12:23Z [Term] id: CL:0002565 name: iris pigment epithelial cell namespace: cell def: "A pigment cell located in the epithelium of the iris." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: part_of UBERON:0002506 ! iris epithelium relationship: part_of UBERON:0002506 ! iris epithelium created_by: tmeehan creation_date: 2011-03-01T05:28:52Z [Term] id: CL:0002566 name: dark melanocyte namespace: cell def: "A melanocyte that appears darker due to content or amount of melanin granules." [GOC:tfm] is_a: CL:0000148 ! melanocyte created_by: tmeehan creation_date: 2011-03-01T05:57:11Z [Term] id: CL:0002567 name: light melanocyte namespace: cell def: "A melanocyte that appears lighter in color." [GOC:tfm] is_a: CL:0000148 ! melanocyte created_by: tmeehan creation_date: 2011-03-01T05:58:23Z [Term] id: CL:0002568 name: mesenchymal stem cell of Wharton's jelly namespace: cell def: "A mesenchymal stem cell that is part of Wharton's jelly." [GOC:tfm] is_a: CL:0002569 ! mesenchymal stem cell of umbilical cord created_by: tmeehan creation_date: 2011-03-01T09:51:18Z [Term] id: CL:0002569 name: mesenchymal stem cell of umbilical cord namespace: cell def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord created_by: tmeehan creation_date: 2011-03-01T09:55:12Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose namespace: cell def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002571 name: hepatic mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of liver." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2011-03-01T09:58:51Z [Term] id: CL:0002572 name: vertebral mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0001035 ! bone cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002412 ! vertebra relationship: part_of UBERON:0002412 ! vertebra created_by: tmeehan creation_date: 2011-03-01T10:40:27Z [Term] id: CL:0002573 name: Schwann cell namespace: cell def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm] xref: BTO:0001220 xref: CALOHA:TS-0898 is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata) intersection_of: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000010 ! peripheral nervous system created_by: tmeehan creation_date: 2011-03-02T01:19:27Z [Term] id: CL:0002574 name: stromal cell of pancreas namespace: cell def: "A stromal cell of the pancreas." [GOC:tfm] is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2011-03-02T02:40:41Z [Term] id: CL:0002575 name: central nervous system pericyte namespace: cell def: "A pericyte of the central nervous system." [GOC:tfm] is_a: CL:0000669 {is_inferred="true"} ! pericyte cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2011-03-02T02:54:18Z [Term] id: CL:0002576 name: perineural cell namespace: cell def: "A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement." [GO:tfm, http://en.wikipedia.org/wiki/Perineurium] is_a: CL:0000186 {is_inferred="true"} ! myofibroblast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000186 ! myofibroblast cell intersection_of: part_of UBERON:0000121 ! perineurium relationship: part_of UBERON:0000121 ! perineurium created_by: tmeehan creation_date: 2011-03-02T03:03:58Z [Term] id: CL:0002577 name: placental epithelial cell namespace: cell def: "An epithelial cell of the placenta." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2011-03-02T03:21:30Z [Term] id: CL:0002578 name: mesenteric preadipocyte namespace: cell def: "A preadipocyte found in mesenteric tissue." [GOC:tfm] is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0002095 ! mesentery relationship: part_of UBERON:0002095 ! mesentery created_by: tmeehan creation_date: 2011-03-03T04:19:40Z [Term] id: CL:0002579 name: omentum preadipocyte namespace: cell is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum created_by: tmeehan creation_date: 2011-03-03T04:19:42Z [Term] id: CL:0002580 name: preadipocyte of the breast namespace: cell def: "A preadipocyte that is part of the breast." [GOC:tfm] is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: tmeehan creation_date: 2011-03-03T04:19:46Z [Term] id: CL:0002581 name: perirenal preadipocyte namespace: cell is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0005406 ! perirenal fat relationship: part_of UBERON:0005406 ! perirenal fat created_by: tmeehan creation_date: 2011-03-03T04:20:04Z [Term] id: CL:0002582 name: visceral preadipocyte namespace: cell def: "A preadipocyte that is part of visceral tissue." [GOC:tfm] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2011-03-03T04:32:56Z [Term] id: CL:0002583 name: subcutaneous preadipocyte namespace: cell def: "A preadipocyte that is part of subcutaneous tissue." [GOC:tfm] is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis created_by: tmeehan creation_date: 2011-03-03T04:33:01Z [Term] id: CL:0002584 name: renal cortical epithelial cell namespace: cell def: "An epithelial cell of the kidney cortex." [GOC:tfm] xref: KUPO:0001016 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: CL:0002585 name: retinal blood vessel endothelial cell namespace: cell def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002586 name: retinal pigment epithelial cell namespace: cell def: "An epithelial cell of the retinal pigmented epithelium." [GOC:tfm] xref: BTO:0004910 xref: FMA:75802 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000149 ! visual pigment cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001782 ! pigmented layer of retina relationship: part_of UBERON:0001782 ! pigmented layer of retina created_by: tmeehan creation_date: 2011-03-06T03:37:09Z [Term] id: CL:0002588 name: smooth muscle cell of the umbilical vein namespace: cell def: "A smooth muscle cell of the umbilical vein." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein created_by: tmeehan creation_date: 2011-03-06T05:00:51Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature namespace: cell def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001529 ! brachiocephalic artery relationship: part_of UBERON:0001529 ! brachiocephalic artery created_by: tmeehan creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature namespace: cell def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0005284 ! brain vasculature relationship: part_of UBERON:0005284 ! brain vasculature created_by: tmeehan creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery namespace: cell def: "A smooth muscle of the pulmonary artery." [GOC:tfm] xref: BTO:0003336 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002592 name: smooth muscle cell of the coronary artery namespace: cell def: "A smooth muscle cell of the coronary artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001621 ! coronary artery relationship: part_of UBERON:0001621 ! coronary artery created_by: tmeehan creation_date: 2011-03-06T05:01:34Z [Term] id: CL:0002593 name: smooth muscle cell of the internal thoracic artery namespace: cell def: "A smooth muscle of the internal thoracic artery." [GOC:tfm] is_a: CL:0002595 ! smooth muscle cell of the subclavian artery intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002456 ! internal thoracic artery relationship: part_of UBERON:0002456 ! internal thoracic artery created_by: tmeehan creation_date: 2011-03-06T05:01:41Z [Term] id: CL:0002594 name: smooth muscle cell of the umbilical artery namespace: cell def: "A smooth muscle cell of the umbilical artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001310 ! umbilical artery relationship: part_of UBERON:0001310 ! umbilical artery created_by: tmeehan creation_date: 2011-03-06T05:01:48Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery namespace: cell def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001533 ! subclavian artery relationship: part_of UBERON:0001533 ! subclavian artery created_by: tmeehan creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery namespace: cell def: "Smooth muscle cell of the carotid artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0005396 ! carotid artery segment relationship: part_of UBERON:0005396 ! carotid artery segment created_by: tmeehan creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002597 name: smooth muscle cell of bladder namespace: cell def: "A smooth muscle cell of the bladder." [GC:tfm] xref: KUPO:0001122 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder created_by: tmeehan creation_date: 2011-03-06T05:43:24Z [Term] id: CL:0002598 name: bronchial smooth muscle cell namespace: cell xref: BTO:0004402 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2011-03-06T05:46:39Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus namespace: cell def: "A smooth muscle cell of the esophagus." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002600 name: smooth muscle cell of trachea namespace: cell def: "A smooth muscle cell of the trachea." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea created_by: tmeehan creation_date: 2011-03-06T05:50:28Z [Term] id: CL:0002601 name: uterine smooth muscle cell namespace: cell def: "A smooth muscle cell of the uterus." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2011-03-06T05:53:28Z [Term] id: CL:0002602 name: annulus pulposus cell namespace: cell synonym: "anulus pulposus cell" EXACT [] is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis relationship: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis created_by: tmeehan creation_date: 2011-03-06T06:50:53Z [Term] id: CL:0002603 name: astrocyte of the cerebellum namespace: cell def: "An astrocyte of the cerebellum." [GOC:tfm] is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum created_by: tmeehan creation_date: 2011-03-06T06:57:27Z [Term] id: CL:0002604 name: astrocyte of the hippocampus namespace: cell is_a: CL:0002605 ! astrocyte of the cerebral cortex is_a: CL:1001580 ! hippocampus glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T06:57:33Z [Term] id: CL:0002605 name: astrocyte of the cerebral cortex namespace: cell def: "An astrocyte of the cerebral cortex." [GOC:tfm] is_a: CL:0012000 ! astrocyte of the forebrain is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex created_by: tmeehan creation_date: 2011-03-06T06:57:36Z [Term] id: CL:0002606 name: astrocyte of the spinal cord namespace: cell def: "An astrocyte of the spinal cord." [GOC:tfm] is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord created_by: tmeehan creation_date: 2011-03-06T07:11:26Z [Term] id: CL:0002607 name: migratory enteric neural crest cell namespace: cell def: "A neural crest cell that gives rise to cells of the enteric nervous system." [GOC:tfm] is_a: CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-03-06T07:24:35Z [Term] id: CL:0002608 name: hippocampal neuron namespace: cell def: "A neuron of the hippocampus." [GOC:tfm] is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T07:31:49Z [Term] id: CL:0002609 name: neuron of cerebral cortex namespace: cell def: "A CNS neuron of the cerebral cortex." [GOC:tfm] synonym: "cortical neuron" EXACT [] xref: BTO:0004102 xref: FMA:84104 is_a: CL:0010012 ! cerebral cortex neuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex created_by: tmeehan creation_date: 2011-03-06T07:37:08Z [Term] id: CL:0002610 name: raphe nuclei neuron namespace: cell def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0004684 ! raphe nuclei relationship: part_of UBERON:0004684 ! raphe nuclei created_by: tmeehan creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002611 name: neuron of the dorsal spinal cord namespace: cell def: "A CNS neuron of the dorsal spinal cord." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord created_by: tmeehan creation_date: 2011-03-06T07:43:34Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord namespace: cell def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002257 ! ventral horn of spinal cord relationship: part_of UBERON:0002257 ! ventral horn of spinal cord created_by: tmeehan creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002613 name: striatum neuron namespace: cell def: "A neuron of the striatum." [GOC:tfm] is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002435 ! striatum relationship: part_of UBERON:0002435 ! striatum created_by: tmeehan creation_date: 2011-03-06T07:47:12Z [Term] id: CL:0002614 name: neuron of the substantia nigra namespace: cell def: "A neuron of the substantia nigra." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002038 ! substantia nigra relationship: part_of UBERON:0002038 ! substantia nigra created_by: tmeehan creation_date: 2011-03-06T07:48:42Z [Term] id: CL:0002615 name: adipocyte of omentum tissue namespace: cell def: "A fat cell that is part of omentum tissue." [GOC:tfm] synonym: "omental adipocyte" EXACT [] synonym: "omental fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum created_by: tmeehan creation_date: 2011-03-14T10:17:00Z [Term] id: CL:0002616 name: perirenal adipocyte cell namespace: cell def: "A fat cell of perirenal fat tissue." [GOC:tfm] synonym: "perirenal fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0005406 ! perirenal fat relationship: part_of UBERON:0005406 ! perirenal fat created_by: tmeehan creation_date: 2011-03-14T10:17:05Z [Term] id: CL:0002617 name: adipocyte of breast namespace: cell def: "A fat cell that is part of the breast." [GOC:tfm] comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA] synonym: "breast adipocyte" EXACT [] synonym: "fat cell of breast" EXACT [] xref: CALOHA:TS-2377 is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: tmeehan creation_date: 2011-03-14T10:17:07Z [Term] id: CL:0002618 name: endothelial cell of umbilical vein namespace: cell def: "An endothelial cell of the umbilical vein." [GOC:tfm] xref: BTO:0004296 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein created_by: tmeehan creation_date: 2011-03-14T11:36:51Z [Term] id: CL:0002619 name: adult endothelial progenitor cell namespace: cell def: "An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial." [GOC:tfm, PMID:20807818, PMID:9020076] synonym: "EPC" EXACT [] is_a: CL:0000566 ! angioblastic mesenchymal cell created_by: tmeehan creation_date: 2011-03-14T12:11:18Z [Term] id: CL:0002620 name: skin fibroblast namespace: cell def: "A fibroblast of skin." [GOC:tfm] xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002621 name: gingival epithelial cell namespace: cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001949 ! gingival epithelium relationship: part_of UBERON:0001949 ! gingival epithelium created_by: tmeehan creation_date: 2011-03-14T12:46:28Z [Term] id: CL:0002622 name: prostate stromal cell namespace: cell def: "A stromal cell of the prostate." [GOC:tfm] xref: BTO:0003972 is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2011-03-14T02:11:10Z [Term] id: CL:0002623 name: acinar cell of salivary gland namespace: cell def: "An acinar cell of salivary gland." [GOC:tfm] is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001596 ! salivary gland glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001044 ! salivary gland relationship: part_of UBERON:0001044 ! salivary gland created_by: tmeehan creation_date: 2011-03-14T02:22:22Z [Term] id: CL:0002624 name: paneth cell of the appendix namespace: cell def: "A paneth cell of the appendix." [GOC:tfm] is_a: CL:0000510 {is_inferred="true"} ! paneth cell is_a: CL:1001585 ! appendix glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix created_by: tmeehan creation_date: 2011-03-15T09:38:18Z [Term] id: CL:0002625 name: seminiferous tubule epithelial cell namespace: cell def: "A cell of the seminiferous tubule epithelium." [GOC:tfm] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium created_by: tmeehan creation_date: 2011-03-15T11:59:23Z [Term] id: CL:0002626 name: immature astrocyte namespace: cell def: "An immature astrocyte." [GOC:dsd] synonym: "immature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002627 name: mature astrocyte namespace: cell def: "A mature astrocyte that is capable of producing cytokines." [GOC:dsd, PMID:12898703, PMID:8734446] comment: Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta. synonym: "activated astrocyte" EXACT [] synonym: "mature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002628 name: immature microglial cell namespace: cell def: "An immature microglial cell with a ramified morphology." [GOC:dsd, PMID:18396103, PMID:19461673] comment: Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative. synonym: "immature microglia" EXACT [] synonym: "quiescent microglia" EXACT [PMID:18396103] synonym: "resting microglia" EXACT [PMID:18396103] is_a: CL:0000129 ! microglial cell [Term] id: CL:0002629 name: mature microglial cell namespace: cell def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [GOC:dsd, PMID:11517395, PMID:14612429, PMID:15246020, PMID:16177057, PMID:18396103, PMID:20021364] comment: Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha. synonym: "activated microglia" EXACT [PMID:18396103] synonym: "mature microglia" EXACT [] synonym: "reactive microglia" EXACT [PMID:18396103] is_a: CL:0000129 {is_inferred="true"} ! microglial cell intersection_of: CL:0000129 ! microglial cell intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0002536 ! capable_of respiratory burst involved in inflammatory response intersection_of: RO:0002215 GO:0002537 ! capable_of nitric oxide production involved in inflammatory response intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0002536 ! capable_of respiratory burst involved in inflammatory response relationship: RO:0002215 GO:0002537 ! capable_of nitric oxide production involved in inflammatory response relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation [Term] id: CL:0002630 name: actinomycete-type spore namespace: cell def: "A spore formed from bacteria in the order Actinomycetales." [GO:0034304, GOC:tfm] is_a: CL:0000520 ! prokaryotic cell created_by: tmeehan creation_date: 2011-06-16T01:01:41Z [Term] id: CL:0002631 name: epithelial cell of upper respiratory tract namespace: cell is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: part_of UBERON:0001557 ! upper respiratory tract relationship: part_of UBERON:0001557 ! upper respiratory tract created_by: tmeehan creation_date: 2011-06-21T12:28:55Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract namespace: cell is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract created_by: tmeehan creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002633 name: respiratory basal cell namespace: cell def: "A basal cell in the respiratory tract." [GOC:tfm, PMID:20699479] synonym: "airway basal cell" EXACT [] synonym: "airway basal stem cell" EXACT [] is_a: CL:0000646 ! basal cell is_a: CL:0002368 ! respiratory epithelial cell created_by: tmeehan creation_date: 2011-06-21T03:11:10Z [Term] id: CL:0002634 name: epithelial cell of anal column namespace: cell def: "An epithelial cell of the anal column." [GOC:tfm] is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0009882 ! anal column relationship: part_of UBERON:0009882 ! anal column created_by: tmeehan creation_date: 2011-07-08T12:11:38Z [Term] id: CL:0002635 name: nonkeratinized epithelial cell of anal column namespace: cell def: "A nonkeratinized epithelial cell of the anal canal." [GOC:tfm] xref: FMA:263146 is_a: CL:0002634 ! epithelial cell of anal column created_by: tmeehan creation_date: 2011-07-08T02:05:33Z [Term] id: CL:0002636 name: nonkeratinized epithelial cell of inferior part of anal canal namespace: cell def: "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." [GOC:tfm] xref: FMA:263144 is_a: CL:0002635 ! nonkeratinized epithelial cell of anal column is_a: CL:1000438 ! epithelial cell of wall of inferior part of anal canal created_by: tmeehan creation_date: 2011-07-08T02:06:53Z [Term] id: CL:0002637 name: keratinized epithelial cell of the anal canal namespace: cell def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [GOC:tfm] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002634 ! epithelial cell of anal column intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal created_by: tmeehan creation_date: 2011-07-08T02:08:40Z [Term] id: CL:0002638 name: bronchioalveolar stem cell namespace: cell def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and Clara cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." [GOC:tfm, PMID:15960971] synonym: "basal epithelial cell of bronchioalveolar duct junction" EXACT [] synonym: "BASC" EXACT [] is_a: CL:1000350 ! basal cell of epithelium of terminal bronchiole is_a: CL:1000351 ! basal cell of epithelium of respiratory bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole intersection_of: part_of UBERON:0001958 ! epithelium of terminal bronchiole relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole relationship: part_of UBERON:0001958 ! epithelium of terminal bronchiole created_by: tmeehan creation_date: 2011-06-21T03:26:08Z [Term] id: CL:0002639 name: amniotic stem cell namespace: cell def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" [GOC:tfm, PMID:20942606] comment: Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now. is_a: CL:0000134 ! mesenchymal cell is_a: CL:0002323 ! amniocyte created_by: tmeehan creation_date: 2011-06-21T03:55:39Z [Term] id: CL:0002640 name: amniotic epithelial stem cell namespace: cell def: "An epithelial fate stem cell derived form the amnion membrane." [GOC:tfm, PMID:20446274] is_a: CL:0000036 ! epithelial fate stem cell created_by: tmeehan creation_date: 2011-06-21T04:06:17Z [Term] id: CL:0002641 name: epithelial cell of esophageal gland proper namespace: cell def: "An epithelial cell of the esophageal gland proper." [GOC:tfm] xref: FMA:256141 is_a: CL:0002657 ! glandular cell of esophagus created_by: tmeehan creation_date: 2011-07-08T02:16:51Z [Term] id: CL:0002642 name: epithelial cell of esophageal cardiac gland namespace: cell def: "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." [GOC:tfm, http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html] xref: FMA:256143 is_a: CL:0002657 ! glandular cell of esophagus created_by: tmeehan creation_date: 2011-07-08T02:16:54Z [Term] id: CL:0002643 name: nonkeratinized cell of stratum corneum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." [GOC:tfm] xref: FMA:263148 is_a: CL:0002654 ! epithelial cell of stratum corneum of esophageal epithelium created_by: tmeehan creation_date: 2011-07-08T02:22:09Z [Term] id: CL:0002644 name: endo-epithelial cell of tympanic part of viscerocranial mucosa namespace: cell def: "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70628 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:25:44Z [Term] id: CL:0002645 name: endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa namespace: cell def: "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." [GOC:tfm] xref: FMA:70629 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:25:46Z [Term] id: CL:0002646 name: epithelial cell of buccal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70577 is_a: CL:0002283 ! ecto-epithelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:34:12Z [Term] id: CL:0002647 name: epithelial cell of anterior palatal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70580 is_a: CL:0002283 ! ecto-epithelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:34:14Z [Term] id: CL:0002648 name: epithelial cell of nasal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70554 is_a: CL:0002283 ! ecto-epithelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:36:06Z [Term] id: CL:0002649 name: epithelial cell of gingival part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70579 is_a: CL:0002283 ! ecto-epithelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:36:11Z [Term] id: CL:0002650 name: epithelial cell of paranasal sinus part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70578 is_a: CL:0002283 ! ecto-epithelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:38:18Z [Term] id: CL:0002651 name: endothelial cell of venous sinus of spleen namespace: cell def: "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." [GOC:tfm] synonym: "stave cell" EXACT [FMA:62817] xref: FMA:72140 is_a: CL:0002262 ! endothelial cell of sinusoid created_by: tmeehan creation_date: 2011-07-08T03:06:49Z [Term] id: CL:0002652 name: endothelial cell of high endothelial venule namespace: cell def: "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [GOC:tfm, PMID:20726857] comment: Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG. synonym: "endothelial cell of postcapillary venule of lymph node" EXACT [] synonym: "HEV cell" EXACT [] xref: FMA:67759 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:1000414 ! endothelial cell of venule created_by: tmeehan creation_date: 2011-07-08T03:14:10Z [Term] id: CL:0002653 name: squamous endothelial cell namespace: cell def: "A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." [GOC:tfm] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:1000414 ! endothelial cell of venule created_by: tmeehan creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002654 name: epithelial cell of stratum corneum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum corneum of esophageal epithelium." [GOC:tfm] xref: FMA:70733 is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2011-07-08T03:46:35Z [Term] id: CL:0002655 name: epithelial cell of stratum spinosum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum spinosum of esophageal epithelium." [GOC:tfm] xref: FMA:70732 is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2011-07-08T03:48:26Z [Term] id: CL:0002656 name: glandular cell of endometrium namespace: cell def: "A glandular epithelial cell of the endometrium." [GOC:tfm] xref: FMA:86489 is_a: CL:1001591 ! oviduct glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2011-07-08T03:54:08Z [Term] id: CL:0002657 name: glandular cell of esophagus namespace: cell def: "A glandular epithelial cell of the esophagus." [GOC:tfm] xref: FMA:86548 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002658 name: glandular cell of the large intestine namespace: cell def: "A glandular epithelial cell of the large intestine." [GOC:tfm] xref: FMA:87194 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2011-07-08T04:03:01Z [Term] id: CL:0002659 name: glandular cell of stomach namespace: cell def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] xref: CALOHA:TS-1284 xref: FMA:86554 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002660 name: luminal cell of acinus of lactiferous gland namespace: cell def: "A luminal epithelial cell of mammary gland located in acinus of structure." [GOC:tfm] comment: Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type. xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland created_by: tmeehan creation_date: 2011-07-11T01:44:31Z [Term] id: CL:0002661 name: luminal cell of lactiferous terminal ductal lobular unit namespace: cell def: "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." [GOC:tfm] xref: FMA:87168 is_a: CL:0002662 ! luminal cell of lactiferous duct created_by: tmeehan creation_date: 2011-07-11T01:44:33Z [Term] id: CL:0002662 name: luminal cell of lactiferous duct namespace: cell def: "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." [GOC:tfm, PMID:19022771] xref: FMA:74504 xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland created_by: tmeehan creation_date: 2011-07-11T01:44:48Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium namespace: cell def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] xref: FMA:83389 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium created_by: tmeehan creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast namespace: cell def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002665 name: otic fibrocyte namespace: cell def: "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." [GOC:tfm, PMID:18353863] is_a: CL:0000135 ! fibrocyte relationship: part_of UBERON:0006725 ! spiral ligament created_by: tmeehan creation_date: 2011-07-11T03:35:01Z [Term] id: CL:0002666 name: type 2 otic fibrocyte namespace: cell def: "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type II otic fibrocyte" EXACT [] synonym: "type II spiral ligament fibrocyte" EXACT [MP:0004488] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:40Z [Term] id: CL:0002667 name: type 5 otic fibrocyte namespace: cell def: "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type V otic fibrocyte" EXACT [] synonym: "type V spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:42Z [Term] id: CL:0002668 name: type 4 otic fibrocyte namespace: cell def: "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." [GOC:tfm, PMID:18353863] synonym: "type IV otic fibrocyte" EXACT [] synonym: "type IV spiral ligament fibrocyte" EXACT [MP:0004490] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:46Z [Term] id: CL:0002669 name: type 3 otic fibrocyte namespace: cell def: "An otic fibrocyte that lines the otic capsule." [GOC:tfm, PMID:18353863] synonym: "type III otic fibrocyte" EXACT [] synonym: "type III spiral ligament fibrocyte" EXACT [MP:0004489] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:50Z [Term] id: CL:0002670 name: type 1 otic fibrocyte namespace: cell def: "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type I otic fibrocyte" EXACT [] synonym: "type I spiral ligament fibrocyte" EXACT [MP:0004487] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:39:27Z [Term] id: CL:0002671 name: endothelial stalk cell namespace: cell def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." [GOC:tfm, PMID:21521739] is_a: CL:0000071 ! blood vessel endothelial cell created_by: tmeehan creation_date: 2011-08-16T01:49:32Z [Term] id: CL:0002672 name: retinal progenitor cell namespace: cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000133 ! neurectodermal cell created_by: tmeehan creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002673 name: tongue muscle cell namespace: cell def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: part_of UBERON:0003273 ! skeletal muscle tissue of tongue relationship: part_of UBERON:0003273 ! skeletal muscle tissue of tongue created_by: tmeehan creation_date: 2011-08-16T03:10:02Z [Term] id: CL:0002674 name: H minus namespace: cell def: "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." [GOC:tfm] synonym: "H- cell" EXACT [] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2011-08-16T03:20:53Z [Term] id: CL:0002675 name: H plus namespace: cell def: "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." [GOC:tfm] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2011-08-16T03:20:58Z [Term] id: CL:0002676 name: neural crest derived neuroblast namespace: cell def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0002677 name: naive regulatory T cell namespace: cell def: "A regulatory T cell that has not encountered antigen." [GOC:tfm] comment: This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell. synonym: "naive regulatory T lymphocyte" EXACT [] synonym: "naive regulatory T-cell" EXACT [] synonym: "naive regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000898 ! naive T cell created_by: tmeehan creation_date: 2011-08-25T03:17:21Z [Term] id: CL:0002678 name: memory regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [GOC:tfm, PMID:21739668] comment: Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell. is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000813 ! memory T cell created_by: tmeehan creation_date: 2011-08-25T03:17:34Z [Term] id: CL:0002679 name: natural helper lymphocyte namespace: cell def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [GOC:tfm, PMID:20023630] is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2011-08-29T10:08:02Z [Term] id: CL:0002680 name: PP cell of intestine namespace: cell def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] is_a: CL:0000696 {is_inferred="true"} ! PP cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-09-27T11:59:01Z [Term] id: CL:0002681 name: kidney cortical cell namespace: cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney created_by: terryh creation_date: 2011-10-25T03:49:41Z [Term] id: CL:0005000 name: spinal cord interneuron namespace: cell def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 {is_inferred="true"} ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:0005001 name: iridoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS] comment: Derived from UBERON:0002342 neural crest. is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005002 name: xanthoblast namespace: cell def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005003 name: leucoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005004 name: pigment erythroblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005005 name: cyanoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005006 name: ionocyte namespace: cell def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0005007 name: Kolmer-Agduhr neuron namespace: cell def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739] synonym: "KA cell" EXACT [] synonym: "KA interneuron" EXACT [PMID:15539490] synonym: "KA neuron" EXACT [PMID:9634146] synonym: "Kolmer-Agduhr cell" EXACT [] is_a: CL:0005000 ! spinal cord interneuron is_a: CL:0011005 ! GABAergic interneuron [Term] id: CL:0005008 name: macular hair cell namespace: cell def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [GO:cvs] is_a: CL:0000202 ! auditory hair cell intersection_of: CL:0000202 ! auditory hair cell intersection_of: part_of UBERON:0000054 ! macula relationship: part_of UBERON:0000054 ! macula [Term] id: CL:0005009 name: renal principal cell namespace: cell def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts." [CL:CVS] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002518 ! kidney epithelial cell [Term] id: CL:0005010 name: renal intercalated cell namespace: cell def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS] synonym: "intercalated cell" EXACT [] xref: FMA:86560 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:0002518 ! kidney epithelial cell [Term] id: CL:0005011 name: renal alpha-intercalated cell namespace: cell def: "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." [CL:CVS] is_a: CL:0005010 ! renal intercalated cell [Term] id: CL:0005012 name: multi-ciliated epithelial cell namespace: cell def: "A ciliated epithelial cell with many cilium." [CL:CVS] is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0005013 name: single ciliated epithelial cell namespace: cell def: "A ciliated epithelial cell with a single cilium." [CL:CVS] is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0005014 name: auditory epithelial support cell namespace: cell def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm] is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002491 ! auditory epithelial cell [Term] id: CL:0005015 name: inner phalangeal cell namespace: cell def: "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." [CL:CVS] xref: FMA:79801 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0005016 name: obsolete apical cell namespace: cell def: "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." [TAIR:TB] comment: replaced_by: PO:0030007 is_obsolete: true [Term] id: CL:0005017 name: obsolete plant basal cell namespace: cell def: "Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote." [TAIR:TB] comment: replaced_by: PO:0002002 is_obsolete: true [Term] id: CL:0005018 name: ghrelin secreting cell namespace: cell def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036321 ! capable_of ghrelin secretion relationship: RO:0002215 GO:0036321 ! capable_of ghrelin secretion [Term] id: CL:0005019 name: pancreatic epsilon cell namespace: cell def: "Ghrelin secreting cells found in the found in the exocrine pancreas." [PMID:14970313] comment: In mammals the endocrine pancreas is called the Islets of Langerhans. synonym: "pancreatic e cell" EXACT [] is_a: CL:0005018 ! ghrelin secreting cell [Term] id: CL:0005020 name: lymphangioblast namespace: cell def: "Lymphatic progenitor cells. " [CL:CVS] comment: Usually express Prox1, or prox1b. is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: RO:0002220 UBERON:0004536 ! adjacent_to lymph vasculature relationship: RO:0002220 UBERON:0004536 ! adjacent_to lymph vasculature created_by: Ceri creation_date: 2012-01-12T04:44:34Z [Term] id: CL:0005021 name: mesenchymal lymphangioblast namespace: cell def: "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." [PMID:15624319, PMID:18430230] is_a: CL:0000134 ! mesenchymal cell is_a: CL:0005020 ! lymphangioblast created_by: Ceri creation_date: 2012-01-12T05:01:22Z [Term] id: CL:0005022 name: vascular lymphangioblast namespace: cell def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [CL:CVS] synonym: "parachordal lymphangioblast" NARROW [] is_a: CL:0005020 {is_inferred="true"} ! lymphangioblast intersection_of: CL:0005020 ! lymphangioblast intersection_of: RO:0002220 UBERON:0001638 ! adjacent_to vein relationship: RO:0002220 UBERON:0001638 ! adjacent_to vein created_by: Ceri creation_date: 2012-01-12T05:21:09Z [Term] id: CL:0005023 name: branchiomotor neuron def: "Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches." [] {editor="ZFIN:CVS"} synonym: "branchi motor neuron " EXACT [] synonym: "special visceral motor neuron" EXACT [] xref: PMID:14699587 is_a: CL:0015000 ! cranial motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002130 UBERON:0004164 ! has synaptic terminal in branchiomeric muscle relationship: RO:0002130 UBERON:0004164 ! has synaptic terminal in branchiomeric muscle [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [] {editor="ZFIN:CVS"} synonym: "somatic motor neuron" EXACT [] is_a: CL:0000108 ! cholinergic neuron is_a: CL:0008014 ! excitatory motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002130 UBERON:0014892 ! has synaptic terminal in skeletal muscle organ relationship: RO:0002130 UBERON:0014892 ! has synaptic terminal in skeletal muscle organ relationship: RO:0002215 GO:0014055 ! capable_of acetylcholine secretion, neurotransmission [Term] id: CL:0005025 name: visceromotor neuron def: "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." [] {editor="ZFIN:CVS"} comment: Note that these neurons do not synapse directly onto muscles synonym: "general visceral motor neuron" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to to both hepatocytes and cholangiocytes as descendants." [PMID:18356246, PMID:20483998 ] {editor="GOC:CVS"} is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0007000 name: preameloblast namespace: cell def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325] comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008 is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0002077 ! ecto-epithelial cell relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: RO:0002220 UBERON:0001763 ! adjacent_to odontogenic papilla created_by: haendel creation_date: 2012-06-15T01:27:01Z [Term] id: CL:0007001 name: skeletogenic cell namespace: cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) synonym: "scleroblast" EXACT [GO_REF:0000034] is_a: CL:0000003 ! native cell created_by: haendel creation_date: 2012-06-15T02:51:27Z [Term] id: CL:0007002 name: precementoblast namespace: cell def: "Skeletogenic cell that has the potential to develop into a cementoblast." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell relationship: part_of UBERON:0005176 ! tooth enamel organ created_by: haendel creation_date: 2012-06-15T04:37:13Z [Term] id: CL:0007003 name: preodontoblast namespace: cell def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0005176 ! tooth enamel organ created_by: haendel creation_date: 2012-06-15T05:15:11Z [Term] id: CL:0007004 name: premigratory neural crest cell namespace: cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] is_a: CL:0000003 ! native cell relationship: part_of UBERON:0002342 ! neural crest created_by: haendel creation_date: 2012-06-27T08:27:35Z [Term] id: CL:0007005 name: notochordal cell namespace: cell def: "Cell that is part of the notochord." [GO_REF:0000034] comment: NOTE: TO DO, notochord development still needs work. is_a: CL:0000003 ! native cell relationship: develops_from CL:0007006 ! chordamesodermal cell relationship: part_of UBERON:0002328 ! notochord created_by: haendel creation_date: 2012-06-27T08:47:31Z [Term] id: CL:0007006 name: chordamesodermal cell namespace: cell def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." [GO_REF:0000034] is_a: CL:0000222 ! mesodermal cell relationship: part_of UBERON:0004880 ! chordamesoderm created_by: haendel creation_date: 2012-06-27T08:52:41Z [Term] id: CL:0007007 name: notochordal sheath cell namespace: cell def: "Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells." [CL:MAH] is_a: CL:0007005 ! notochordal cell created_by: haendel creation_date: 2012-06-27T09:26:37Z [Term] id: CL:0007008 name: notochordal vacuole cell namespace: cell def: "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." [CL:MAH] synonym: "chordablast" EXACT [GO_REF:0000034] synonym: "chordoblast" EXACT [PMID:14574572] is_a: CL:0007005 ! notochordal cell created_by: haendel creation_date: 2012-06-27T09:29:30Z [Term] id: CL:0007009 name: prechondroblast namespace: cell def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell created_by: haendel creation_date: 2012-06-27T10:44:01Z [Term] id: CL:0007010 name: preosteoblast namespace: cell def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [GO_REF:0000034] synonym: "osteoprogenitor cell" EXACT [] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: part_of UBERON:0008883 ! osteoid created_by: haendel creation_date: 2012-06-27T10:57:21Z [Term] id: CL:0007011 name: enteric neuron namespace: cell def: "Neuron that is part of the enteric nervous system." [CL:MAH] is_a: CL:0000029 ! neuron neural crest derived is_a: CL:0000107 ! autonomic neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002005 ! enteric nervous system relationship: develops_from CL:0002607 ! migratory enteric neural crest cell relationship: part_of UBERON:0002005 ! enteric nervous system created_by: haendel creation_date: 2012-06-28T08:20:31Z [Term] id: CL:0007012 name: non-terminally differentiated odontoblast namespace: cl def: "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." [GO_REF:0000034, PSPUB:0000170] is_a: CL:0000060 ! odontoblast [Term] id: CL:0007013 name: terminally differentiated odontoblast namespace: cl def: "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." [GO_REF:0000034] is_a: CL:0000060 ! odontoblast [Term] id: CL:0007014 name: obsolete cell line cell namespace: cell def: "OBSOLETE: A cultured cell that has been passaged at least one time in culture." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "passaged cultured cell" EXACT [] is_obsolete: true replaced_by: CLO:0000001 created_by: haendel creation_date: 2012-11-28T11:54:59Z [Term] id: CL:0007015 name: obsolete mortal cell line cell namespace: cell def: "OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can)." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'mortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "finite cell line cell" EXACT [] synonym: "primary cell line cell" RELATED [] is_obsolete: true replaced_by: CLO:0000018 created_by: haendel creation_date: 2012-11-28T11:56:20Z [Term] id: CL:0007016 name: adaxial cell namespace: cell def: "Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm." [PMID:8951054] comment: In teleosts, adaxial cells give rise to slow muscle myoblasts. is_a: CL:0000680 ! muscle precursor cell relationship: part_of UBERON:0003059 ! presomitic mesoderm created_by: haendel creation_date: 2012-12-30T12:43:15Z [Term] id: CL:0007017 name: Stiftchenzellen def: "An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis. " [PMID:1087183] comment: Taxon specificity not yet fully known, but are known in anuran larvae but not in adults. is_a: CL:0000206 ! chemoreceptor cell relationship: has_part GO:0005902 ! microvillus relationship: part_of UBERON:0001003 ! epidermis created_by: haendel [Term] id: CL:0007018 name: epidermal ciliary cell def: "Ciliated cell of the embryonic epidermis and functions in embryonic movements." [PMCID:PMC3046089] comment: Taxon specificity not clear -present in embryonic anurans. is_a: CL:0000064 ! ciliated cell is_a: CL:0002321 ! embryonic cell relationship: has_plasma_membrane_part GO:0005929 ! cilium relationship: part_of UBERON:0001003 ! epidermis created_by: haendel [Term] id: CL:0007019 name: epidermal mucus secreting cell comment: taxon specificity not clear. Appears in early larval stages of anurans and persists after metamorphosis. is_a: CL:0000319 ! mucus secreting cell created_by: haendel [Term] id: CL:0007020 name: bottle cell def: "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." [PMID:3197630] is_a: CL:0000007 ! early embryonic cell created_by: haendel [Term] id: CL:0007021 name: alarm substance cell def: "Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]" [ISBN-10:0412429403] synonym: "club cell" EXACT [ISBN-10:0412429403] is_a: CL:0000151 ! secretory cell is_a: CL:0000473 ! defensive cell relationship: part_of UBERON:0001003 ! epidermis relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell created_by: haendel [Term] id: CL:0007022 name: micropylar cell def: "A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg." [PMID:18582455 , ZFA:0005239] synonym: "plug cell" EXACT [] is_a: CL:0000548 ! animal cell relationship: part_of UBERON:0001305 ! ovarian follicle created_by: haendel [Term] id: CL:0007023 name: flask cell def: "Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis. " [DOI:10.1007/BF00717048] is_a: CL:0000003 ! native cell relationship: part_of UBERON:0001003 ! epidermis created_by: haendel [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] is_a: CL:0000188 ! skeletal muscle cell is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: develops_from CL:0000515 ! skeletal muscle myoblast relationship: has_part GO:0030017 ! sarcomere relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0008003 name: somatic muscle myotube def: "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." [PMID:22274696, PMID:8720463] is_a: CL:0002372 ! myotube is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0008004 name: somatic muscle cell def: "A muscle cell that is part of some somatic muscle." [GOC:dos] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008005 name: obliquely striated somatic muscle cell def: "A somatic muscle cell that is oblquely striated. Examples include the somatic muscles of nematodes." [PMID:8720463] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000444 ! obliquely striated muscle cell is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002479 ! obliquely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002479 ! obliquely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0008006 name: muscle founder cell def: "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." [PMID:22274696] is_a: CL:0000056 ! myoblast relationship: RO:0002203 CL:0008003 ! develops into somatic muscle myotube [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle" [GOC:dos] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: bearer_of PATO:0001410 {all_some="true"} ! striated [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: bearer_of PATO:0002478 {all_some="true"} ! transversely striated [Term] id: CL:0008010 name: cranial somatomotor neuron def: "A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue." [PMID:14699587] is_a: CL:0005024 ! somatomotor neuron is_a: CL:0015000 ! cranial motor neuron intersection_of: CL:0015000 ! cranial motor neuron intersection_of: RO:0002130 UBERON:0014892 ! has synaptic terminal in skeletal muscle organ relationship: RO:0002130 UBERON:0014892 ! has synaptic terminal in skeletal muscle organ [Term] id: CL:0008013 name: cranial visceromotor neuron def: " A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head." [PMID:14699587] is_a: CL:0005025 ! visceromotor neuron is_a: CL:0015000 ! cranial motor neuron [Term] id: CL:0008014 name: excitatory motor neuron def: "A motor neuron that is capable of directly inducing muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. is_a: CL:0000100 ! motor neuron [Term] id: CL:0008015 name: inhibitory motor neuron def: "A motor neuron that is capable of directly inhibiting muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. is_a: CL:0000100 ! motor neuron [Term] id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] synonym: "spinal sensory neuron" EXACT [] is_a: CL:0000101 {is_inferred="true"} ! sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: part_of UBERON:0001780 ! spinal nerve relationship: part_of UBERON:0001780 ! spinal nerve [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 is_a: CL:0002371 ! somatic cell [Term] id: CL:0009002 name: inflammatory cell def: "Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Inflammatory_response is_a: CL:0002371 ! somatic cell [Term] id: CL:0009003 name: larval midgut cell def: "Any cell in the midgut (middle subdivision of a digestive tract) of a larva." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Insect#Midgut is_a: CL:0002371 ! somatic cell [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [] xref: GOC:pr xref: PMID:10702418 is_a: CL:0002371 ! somatic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0009005 name: salivary gland cell def: "Any cell in a salivary gland." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Salivary_gland is_a: CL:0002371 ! somatic cell [Term] id: CL:0010001 name: stromal cell of bone marrow def: "a stromal cell that is part_of a bone marrow" [] synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: GOC:cjm [Term] id: CL:0010002 name: epithelial cell of umbilical artery def: "a epithelial cell that is part_of a umbilical artery" [] synonym: "umbilical artery epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001310 ! umbilical artery relationship: part_of UBERON:0001310 ! umbilical artery created_by: GOC:cjm [Term] id: CL:0010003 name: epithelial cell of alveolus of lung def: "a epithelial cell that is part_of a alveolus of lung" [] comment: May be merged with pneumocyte in future synonym: "alveolus of lung epithelial cell" EXACT [] is_a: CL:0000082 ! epithelial cell of lung intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung created_by: GOC:cjm [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "a mononuclear cell that is part_of a bone marrow" [] synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: GOC:cjm [Term] id: CL:0010005 name: atrioventricular bundle cell def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell" EXACT [] is_a: CL:0010007 ! His-Purkinje system cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0002353 ! atrioventricular bundle relationship: part_of UBERON:0002353 ! atrioventricular bundle [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010007 name: His-Purkinje system cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0004146 ! His-Purkinje system relationship: part_of UBERON:0004146 ! His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010009 name: camera-type eye photoreceptor cell synonym: "camera type eye photoreceptor cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000966 {editor="GOC:cjm"} ! retina [Term] id: CL:0010010 name: cerebellar stellate cell is_a: CL:0000122 ! stellate cell is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000122 ! stellate cell intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0010011 name: cerebral cortex GABAergic interneuron def: "a GABAergic neuron that is part_of a cerebral cortex" [] is_a: CL:0000617 ! GABAergic neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000617 ! GABAergic neuron intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0010012 name: cerebral cortex neuron def: "a neuron that is part_of a cerebral cortex" [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0010020 name: cardiac glial cell is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010021 name: cardiac myoblast is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell relationship: RO:0002203 CL:0000746 ! develops into cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron is_a: CL:0000540 ! neuron is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0011000 name: dorsal horn interneuron def: "A CNS interneuron located in the dorsal horn of the spinal cord." [GOC:nv] synonym: "dorsal spinal cord interneuron" RELATED [] is_a: CL:0002611 ! neuron of the dorsal spinal cord is_a: CL:0005000 {is_inferred="true"} ! spinal cord interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] is_a: CL:0000100 {is_inferred="true"} ! motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:0011002 name: lateral motor column neuron def: "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [GOC:nv] comment: Need to MIREOT in 'spinal cord lateral column' from Uberon is_a: CL:0011001 ! spinal cord motor neuron [Term] id: CL:0011003 name: magnocellular neurosecretory cell def: "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that secretes the hormones oxytocin and vasopressin." [GOC:nv, MP:0009467] synonym: "magnocellular neuron" EXACT [] is_a: CL:0000381 ! neurosecretory neuron relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus relationship: part_of UBERON:0006568 ! hypothalamic nucleus [Term] id: CL:0011004 name: lens fiber cell def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GO:0070307, GOC:nv] synonym: "lens fibre cell" EXACT [] is_a: CL:0002222 ! vertebrate lens cell [Term] id: CL:0011005 name: GABAergic interneuron def: "An interneuron that uses GABA as a vesicular neurotransmitter." [GOC:nv] is_a: CL:0000099 ! interneuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000099 ! interneuron intersection_of: CL:0000617 ! GABAergic neuron [Term] id: CL:0011006 name: lugaro cell def: "An inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:nv] is_a: CL:0000402 ! CNS interneuron is_a: CL:0011005 ! GABAergic interneuron is_a: CL:1001611 ! cerebellar neuron relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: CL:0011100 name: galanergic neuron def: "Neuron that secretes the neurotransmitter galanin." [PMID:23159249] {editor="ZFIN:CVS", editor="ZFIN:YB", editor="GOC:NV"} is_a: CL:0000540 ! neuron [Term] id: CL:0011101 name: chorionic trophoblast cell def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV] is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: part_of UBERON:0003124 ! chorion relationship: part_of UBERON:0003124 ! chorion [Term] id: CL:0011102 name: parasympathetic neuron def: "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." [isbn 0080923437] {editor="GOC:NV"} is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0011103 name: sympathetic neuron def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [ isbn 0080923437] {editor="GOC:NV"} is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0011104 name: interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer." [PMID:12771169] {editor="GOC:NV"} comment: Need to MIREOT retinal inner nuclear layer is_a: CL:0000099 ! interneuron [Term] id: CL:0011105 name: dopamanergic interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer, using dopamine. " [PMID:12771169] {editor="GOC:NV"} comment: Need to MIREOT retinal inner nuclear layer (part_of) is_a: CL:0011104 ! interplexiform cell [Term] id: CL:0011106 name: GABAnergic interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer using GABA. " [PMID:12771169] {editor="GOC:NV"} comment: Need to MIREOT retinal inner nuclear layer (part of) is_a: CL:0011104 ! interplexiform cell [Term] id: CL:0011107 name: Muller cell def: "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.\n" [PMID:21911394] {editor="GOC:NV"} synonym: "Muller glia " EXACT [] synonym: "Mller cell" EXACT [] is_a: CL:0000681 ! radial glial cell is_a: CL:0009004 ! retinal cell relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0011108 name: colon epithelial cell def: "Epithelial cell that is part of the colon epithelium. " [] {editor="GOC:NV"} synonym: "colonic epithelial cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0001155 ! colon [Term] id: CL:0011109 name: hypocretin-secreting neuron def: "A neuron that releases hypocretin as a neurotransmitter." [PMID:23848055] {editor="GOC:NV"} synonym: "orexin" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0011110 name: histaminergic neuron def: "Neuron that secretes histamine." [PMID:22677810] {editor="GOC:NV"} is_a: CL:0002274 ! histamine secreting cell is_a: CL:0011112 ! magnocellular neurosecretory cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061538 ! capable_of histamine secretion, neurotransmission relationship: RO:0002215 GO:0061538 ! capable_of histamine secretion, neurotransmission [Term] id: CL:0011111 name: gonadotropin releasing neuron def: "Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction." [PMID:21828096] {editor="GOC:NV"} synonym: "GnRH neuron" EXACT [] synonym: "GnRH-secreting neuron" EXACT [] is_a: CL:0011112 ! magnocellular neurosecretory cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0032274 ! capable_of gonadotropin secretion relationship: RO:0002215 GO:0032274 ! capable_of gonadotropin secretion [Term] id: CL:0011112 name: magnocellular neurosecretory cell def: "Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland." [PMID:10711808] {editor="GOC:NV"} is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0030103 ! capable_of vasopressin secretion intersection_of: RO:0002215 GO:0046879 ! capable_of hormone secretion relationship: RO:0002215 GO:0030103 ! capable_of vasopressin secretion relationship: RO:0002215 GO:0046879 ! capable_of hormone secretion [Term] id: CL:0011113 name: spiral ganglion neuron def: "Neuron found in the spriral ganglion." [] {editor="GOC:NV"} is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000395 ! cochlear ganglion relationship: part_of UBERON:0000395 ! cochlear ganglion [Term] id: CL:0012000 name: astrocyte of the forebrain namespace: cell def: "An astrocyte of the forebrain." [] synonym: "forebrain astrocyte" EXACT [] is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain created_by: tberardini [Term] id: CL:0012001 name: neuron of the forebrain namespace: cell def: "A CNS neuron of the forebrain." [] synonym: "forebrain neuron" EXACT [] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain created_by: tberardini [Term] id: CL:0013000 name: forebrain radial glial cell is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: CL:0015000 name: cranial motor neuron def: "Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. " [] {editor="ZFIN:CVS\n"} synonym: "cranial motoneuron" EXACT [] xref: PMID:14699587 \n is_a: CL:0000100 ! motor neuron [Term] id: CL:1000001 name: retrotrapezoid nucleus neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0009918 ! retrotrapezoid nucleus relationship: part_of UBERON:0009918 ! retrotrapezoid nucleus [Term] id: CL:1000022 name: mesonephric nephron tubule epithelial cell is_a: CL:1000494 ! epithelial cell of renal tubule intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005329 ! mesonephric nephron tubule relationship: part_of UBERON:0005329 ! mesonephric nephron tubule [Term] id: CL:1000042 name: forebrain neuroblast is_a: CL:0000031 ! neuroblast intersection_of: CL:0000031 ! neuroblast intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: CL:1000050 name: lateral line nerve glial cell is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0008906 ! lateral line nerve relationship: part_of UBERON:0008906 ! lateral line nerve [Term] id: CL:1000073 name: spinal cord radial glial cell is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:1000082 name: stretch receptor cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:1000083 name: stratified keratinized epithelial stem cell namespace: cell is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000085 name: stratified non keratinized epithelial stem cell namespace: cell is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000090 name: pronephric nephron tubule epithelial cell is_a: CL:1000494 ! epithelial cell of renal tubule intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005310 ! pronephric nephron tubule relationship: part_of UBERON:0005310 ! pronephric nephron tubule [Term] id: CL:1000123 name: metanephric nephron tubule epithelial cell is_a: CL:1000494 ! epithelial cell of renal tubule intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005146 ! metanephric nephron tubule relationship: part_of UBERON:0005146 ! metanephric nephron tubule [Term] id: CL:1000143 name: lung goblet cell is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002370 ! respiratory goblet cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000147 name: heart valve cell is_a: CL:0000663 ! valve cell intersection_of: CL:0000663 ! valve cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:1000155 name: malpighian tubule stellate cell is_a: CL:0000122 ! stellate cell intersection_of: CL:0000122 ! stellate cell intersection_of: part_of UBERON:0001054 ! Malpighian tubule relationship: part_of UBERON:0001054 ! Malpighian tubule [Term] id: CL:1000182 name: malpighian tubule tip cell is_a: CL:0000423 ! tip cell intersection_of: CL:0000423 ! tip cell intersection_of: part_of UBERON:0001054 ! Malpighian tubule relationship: part_of UBERON:0001054 ! Malpighian tubule [Term] id: CL:1000191 name: pillar cell namespace: cell def: "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." [GOC:tfm, PMID:12417662] synonym: "cochlear pillar cell" RELATED [] synonym: "pillar cell of cochlea" EXACT [] synonym: "pillar cell of corti" EXACT [] synonym: "rod cell of Corti" EXACT [] xref: FMA:75722 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:1000217 name: growth plate cartilage chondrocyte is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: part_of UBERON:0004129 ! growth plate cartilage relationship: part_of UBERON:0004129 ! growth plate cartilage [Term] id: CL:1000222 name: stomach neuroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: CL:1000223 name: lung neuroendocrine cell is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0000165 ! neuroendocrine cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000236 name: posterior lateral line nerve glial cell is_a: CL:1000050 ! lateral line nerve glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:2000175 ! posterior lateral line nerve relationship: part_of UBERON:2000175 ! posterior lateral line nerve [Term] id: CL:1000239 name: anterior lateral line nerve glial cell is_a: CL:1000050 ! lateral line nerve glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:2000425 ! anterior lateral line nerve relationship: part_of UBERON:2000425 ! anterior lateral line nerve [Term] id: CL:1000245 name: posterior lateral line ganglion neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:2001314 ! posterior lateral line ganglion relationship: part_of UBERON:2001314 ! posterior lateral line ganglion [Term] id: CL:1000271 name: lung ciliated cell is_a: CL:0000064 ! ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000272 name: lung secretory cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000274 name: trophectodermal cell namespace: cell synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:1000275 name: smooth muscle cell of small intestine namespace: cell def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050] xref: FMA:15050 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000276 name: smooth muscle fiber of duodenum namespace: cell def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058] xref: FMA:15058 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000277 name: smooth muscle fiber of jejunum namespace: cell def: "A smooth muscle cell that is part of the jejunum." [GOC:tfm] synonym: "non-striated muscle fiber of jejunum" EXACT [FMA:15062] xref: FMA:15062 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000278 name: smooth muscle fiber of ileum namespace: cell def: "A smooth muscle cell that is part of the ileum." [GOC:tfm] synonym: "non-striated muscle fiber of ileum" EXACT [FMA:15066] xref: FMA:15066 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: CL:1000279 name: smooth muscle cell of large intestine namespace: cell def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653] xref: FMA:15653 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine [Term] id: CL:1000280 name: smooth muscle cell of colon namespace: cell def: "A smooth muscle cell that is part of the colon." [GOC:tfm] synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663] xref: FMA:15663 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: CL:1000281 name: smooth muscle cell of cecum namespace: cell def: "A smooth muscle cell that is part of the cecum." [GOC:tfm] synonym: "non-striated muscle fiber of cecum" EXACT [FMA:15681] synonym: "smooth muscle fiber of cecum" EXACT [] xref: FMA:15681 is_a: CL:1000280 ! smooth muscle cell of colon intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: CL:1000282 name: smooth muscle fiber of ascending colon namespace: cell def: "A smooth muscle cell that is part of the ascending colon." [GOC:tfm] synonym: "non-striated muscle fiber of ascending colon" EXACT [FMA:17518] xref: FMA:17518 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001156 ! ascending colon relationship: part_of UBERON:0001156 ! ascending colon [Term] id: CL:1000283 name: smooth muscle fiber of transverse colon namespace: cell def: "A smooth muscle cell that is part of the transverse colon." [GOC:tfm] synonym: "non-striated muscle fiber of transverse colon" EXACT [FMA:17519] xref: FMA:17519 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001157 ! transverse colon relationship: part_of UBERON:0001157 ! transverse colon [Term] id: CL:1000284 name: smooth muscle fiber of descending colon namespace: cell def: "A smooth muscle cell that is part of the descending colon." [GOC:tfm] synonym: "non-striated muscle fiber of descending colon" EXACT [FMA:17520] xref: FMA:17520 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001158 ! descending colon relationship: part_of UBERON:0001158 ! descending colon [Term] id: CL:1000285 name: smooth muscle cell of sigmoid colon namespace: cell def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521] xref: FMA:17521 is_a: CL:0000540 ! neuron is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:0000540 ! neuron intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001159 ! sigmoid colon intersection_of: part_of UBERON:2001391 ! anterior lateral line ganglion relationship: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:2001391 ! anterior lateral line ganglion [Term] id: CL:1000286 name: smooth muscle cell of rectum namespace: cell def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522] synonym: "smooth muscle fiber of rectum" EXACT [] xref: FMA:17522 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: CL:1000287 name: myocyte of anterior internodal tract namespace: cell def: "A muscle cell that is part of the anterior internodal tract." [GOC:tfm] xref: FMA:223276 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000288 name: myocyte of atrial branch of anterior internodal tract namespace: cell def: "A muscle cell that is part of the atrial branch of anterior internodal tract." [GOC:tfm] xref: FMA:223277 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000289 name: myocyte of atrial septal branch of anterior internodal tract namespace: cell def: "A muscle cell that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm] xref: FMA:223278 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000290 name: myocyte of middle internodal tract namespace: cell def: "A muscle cell that is part of the middle internodal tract." [GOC:tfm] xref: FMA:223279 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000291 name: myocyte of posterior internodal tract namespace: cell def: "A muscle cell that is part of the posterior internodal tract." [GOC:tfm] xref: FMA:223280 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000296 name: epithelial cell of urethra namespace: cell def: "An epithelial cell that is part of the urethra." [GOC:tfm] xref: FMA:256165 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: CL:1001320 ! urethra cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: CL:1000298 name: mesothelial cell of dura mater namespace: cell def: "A mesothelial cell that is part of the dura mater." [GOC:tfm] synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516] xref: FMA:256516 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002363 ! dura mater relationship: part_of UBERON:0002363 ! dura mater [Term] id: CL:1000299 name: fibroblast of connective tissue of prostate namespace: cell def: "A fibroblast that is part of the connective tissue of prostate." [GOC:tfm] xref: FMA:261271 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000300 name: fibroblast of outer membrane of prostatic capsule namespace: cell def: "A fibroblast that is part of the outer membrane of prostatic capsule." [GOC:tfm] xref: FMA:261273 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000301 name: fibroblast of subepithelial connective tissue of prostatic gland namespace: cell def: "A fibroblast that is part of the subepithelial connective tissue of prostatic gland." [GOC:tfm] xref: FMA:261275 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000302 name: fibroblast of papillary layer of dermis namespace: cell def: "A fibroblast that is part of the papillary layer of dermis." [GOC:tfm] xref: FMA:261277 is_a: CL:0002551 {is_inferred="true"} ! fibroblast of dermis intersection_of: CL:0002551 ! fibroblast of dermis intersection_of: part_of UBERON:0001992 ! papillary layer of dermis relationship: part_of UBERON:0001992 ! papillary layer of dermis [Term] id: CL:1000303 name: fibroblast of areolar connective tissue namespace: cell def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] xref: FMA:261279 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0006815 ! areolar connective tissue relationship: part_of UBERON:0006815 ! areolar connective tissue [Term] id: CL:1000304 name: fibroblast of connective tissue of nonglandular part of prostate namespace: cell def: "A fibroblast that is part of the connective tissue of nonglandular part of prostate." [GOC:tfm] xref: FMA:261281 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000305 name: fibroblast of connective tissue of glandular part of prostate namespace: cell def: "A fibroblast that is part of the connective tissue of glandular part of prostate." [GOC:tfm] xref: FMA:261283 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery namespace: cell def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] xref: FMA:261285 is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue namespace: cell def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0007846 ! dense regular connective tissue relationship: part_of UBERON:0002521 ! elastic tissue relationship: part_of UBERON:0007846 ! dense regular connective tissue [Term] id: CL:1000308 name: fibrocyte of adventitia of ureter namespace: cell def: "A fibrocyte that is part of the adventitia of ureter." [GOC:tfm] xref: FMA:261289 is_a: CL:0000135 {is_inferred="true"} ! fibrocyte is_a: CL:1000708 ! ureter adventitial cell intersection_of: CL:0000135 ! fibrocyte intersection_of: part_of UBERON:0001252 ! adventitia of ureter relationship: part_of UBERON:0001252 ! adventitia of ureter [Term] id: CL:1000309 name: epicardial adipocyte namespace: cell def: "A fat cell that is part of the epicardial fat." [GOC:tfm] synonym: "adipocyte of epicardial fat" EXACT [FMA:261293] synonym: "epicardial fat cell" EXACT [FMA:261293] xref: FMA:261293 is_a: CL:0000136 ! fat cell is_a: CL:0002494 ! cardiocyte relationship: part_of UBERON:0002348 ! epicardium [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle namespace: cell def: "A fat cell that is part of the epicardial fat of right ventricle." [GOC:tfm] synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297] synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297] xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle namespace: cell def: "A fat cell that is part of the epicardial fat of left ventricle." [GOC:tfm] synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300] synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300] xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: CL:1000312 name: bronchial goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of bronchus." [GOC:tfm] synonym: "goblet cell of epithelium of bronchus" EXACT [FMA:263032] xref: FMA:263032 is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:0002370 ! respiratory goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: CL:1000313 name: gastric goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of stomach." [GOC:tfm] synonym: "goblet cell of epithelium of stomach" EXACT [FMA:263035] xref: FMA:263035 is_a: CL:0000160 ! goblet cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001276 ! epithelium of stomach [Term] id: CL:1000314 name: gastric cardiac gland goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of gastric cardiac gland." [GOC:tfm] synonym: "goblet cell of epithelium of gastric cardiac gland" EXACT [] xref: FMA:263038 is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0008859 ! cardiac gastric gland relationship: part_of UBERON:0008859 ! cardiac gastric gland [Term] id: CL:1000315 name: endocardial cushion cell namespace: cell def: "A goblet cell that is part of the epithelium of principal gastric gland." [GOC:tfm] synonym: "goblet cell of epithelium of principal gastric gland" EXACT [] xref: FMA:263040 is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0009971 ! principal gastric gland relationship: part_of UBERON:0009971 ! principal gastric gland [Term] id: CL:1000316 name: obsolete goblet cell of epithelium of small intestine namespace: cell def: "OBSOLETE: A goblet cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263042 is_obsolete: true replaced_by: CL:1000495 [Term] id: CL:1000317 name: intestinal villus goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of intestinal villus." [GOC:tfm] synonym: "goblet cell of epithelium of intestinal villus" EXACT [] xref: FMA:263046 is_a: CL:1000495 ! small intestine goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000318 name: obsolete small intestine crypt goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263050 is_obsolete: true [Term] id: CL:1000319 name: ureter epithelial cell namespace: cell def: "OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263052 is_a: CL:0000066 ! epithelial cell is_a: CL:1000601 ! ureteral cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter is_obsolete: true [Term] id: CL:1000320 name: axial mesoderm cell namespace: cell def: "A goblet cell that is part of the epithelium of large intestine." [GOC:tfm] synonym: "goblet cell of epithelium of large intestine" EXACT [] xref: FMA:263054 is_a: CL:0000160 ! goblet cell is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine [Term] id: CL:1000321 name: large intestine crypt goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of large intestine." [GOC:tfm] xref: FMA:263056 is_a: CL:1000320 ! axial mesoderm cell [Term] id: CL:1000322 name: pancreatic goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of pancreatic duct." [GOC:tfm] synonym: "goblet cell of epithelium of pancreatic duct" EXACT [FMA:263058] xref: FMA:263058 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0000160 ! goblet cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0009970 ! epithelium of pancreatic duct [Term] id: CL:1000323 name: pylroric gastric gland goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of pyloric gland." [GOC:tfm] synonym: "goblet cell of epithelium of pyloric gland" EXACT [] xref: FMA:263061 is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0008861 ! pyloric gastric gland relationship: part_of UBERON:0008861 ! pyloric gastric gland [Term] id: CL:1000324 name: duodenal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of duodenum." [GOC:tfm] synonym: "goblet cell of epithelium proper of duodenum" EXACT [] xref: FMA:263063 is_a: CL:1000317 ! intestinal villus goblet cell is_a: CL:1001589 ! duodenum glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1000325 name: jejunal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of jejunum." [GOC:tfm] synonym: "goblet cell of epithelium proper of jejunum" EXACT [] xref: FMA:263065 is_a: CL:1000317 ! intestinal villus goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000326 name: ileal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of ileum." [GOC:tfm] synonym: "goblet cell of epithelium proper of ileum" EXACT [] xref: FMA:263067 is_a: CL:1000317 ! intestinal villus goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: CL:1000327 name: appendix goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of appendix." [GOC:tfm] synonym: "goblet cell of epithelium proper of appendix" EXACT [] xref: FMA:263069 is_a: CL:1000320 ! axial mesoderm cell is_a: CL:1001585 ! appendix glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: CL:1000328 name: obsolete goblet cell of epithelium proper of large intestine namespace: cell def: "OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine." [GOC:tfm] xref: FMA:263071 is_obsolete: true [Term] id: CL:1000329 name: tracheal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of trachea." [GOC:tfm] synonym: "goblet cell of epithelium of trachea" EXACT [FMA:263075] xref: FMA:263075 is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:0002370 ! respiratory goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:1000330 name: serous cell of epithelium of trachea namespace: cell def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] xref: FMA:263078 is_a: CL:0000313 {is_inferred="true"} ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea [Term] id: CL:1000331 name: serous cell of epithelium of bronchus namespace: cell def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] xref: FMA:263080 is_a: CL:0000313 ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus [Term] id: CL:1000332 name: serous cell of epithelium of terminal bronchiole namespace: cell def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] xref: FMA:263082 is_a: CL:1000333 ! serous cell of epithelium of lobular bronchiole intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0001958 ! epithelium of terminal bronchiole relationship: part_of UBERON:0001958 ! epithelium of terminal bronchiole [Term] id: CL:1000333 name: serous cell of epithelium of lobular bronchiole namespace: cell def: "A serous secreting cell that is part of the epithelium of bronchiole." [GOC:tfm] xref: FMA:263084 is_a: CL:1000272 ! lung secretory cell is_a: CL:1000331 ! serous cell of epithelium of bronchus intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole [Term] id: CL:1000334 name: enterocyte of epithelium of small intestine namespace: cell def: "An enterocyte that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263086 is_a: CL:0000584 {is_inferred="true"} ! enterocyte is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1000335 name: enterocyte of epithelium of intestinal villus namespace: cell def: "An enterocyte that is part of the epithelium of intestinal villus." [GOC:tfm] xref: FMA:263088 is_a: CL:1000334 ! enterocyte of epithelium of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0013636 ! epithelium of intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000337 name: enterocyte of epithelium of duodenal gland namespace: cell def: "An enterocyte that is part of the epithelium of duodenal gland." [GOC:tfm] xref: FMA:263092 is_a: CL:0000584 ! enterocyte is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001212 ! duodenal gland relationship: part_of UBERON:0001212 ! duodenal gland [Term] id: CL:1000338 name: enterocyte of epithelium of crypt of lieberkuhn of small intestine namespace: cell def: "An enterocyte that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263094 is_a: CL:1000334 ! enterocyte of epithelium of small intestine relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn [Term] id: CL:1000339 name: enterocyte of epithelium proper of small intestine namespace: cell def: "An enterocyte that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263096 is_a: CL:1000334 ! enterocyte of epithelium of small intestine [Term] id: CL:1000340 name: enterocyte of epithelium proper of duodenum namespace: cell def: "An enterocyte that is part of the epithelium proper of duodenum." [GOC:tfm] xref: FMA:263098 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine relationship: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000341 name: enterocyte of epithelium proper of jejunum namespace: cell def: "An enterocyte that is part of the epithelium proper of jejunum." [GOC:tfm] xref: FMA:263100 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine [Term] id: CL:1000342 name: enterocyte of epithelium proper of ileum namespace: cell def: "An enterocyte that is part of the epithelium proper of ileum." [GOC:tfm] xref: FMA:263102 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine [Term] id: CL:1000343 name: paneth cell of epithelium of small intestine namespace: cell def: "A paneth cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263104 is_a: CL:0000510 {is_inferred="true"} ! paneth cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1000344 name: paneth cell of epithelium proper of small intestine namespace: cell def: "A Paneth cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263106 is_a: CL:1000343 ! paneth cell of epithelium of small intestine [Term] id: CL:1000345 name: paneth cell of epithelium of crypt of lieberkuhn of small intestine namespace: cell def: "A Paneth cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263108 is_a: CL:1000343 ! paneth cell of epithelium of small intestine relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn [Term] id: CL:1000346 name: vacuolar absorptive cell of epithelium proper of large intestine namespace: cell alt_id: CL:1000336 def: "MERGED DEFINITION: TARGET DEFINITION: A columnar cell of the colon that is part of the epithelium proper of large intestine. SOURCE DEFINITION: An enterocyte that is part of the epithelium proper of large intestine." [GOC:tfm] synonym: "enterocyte of epithelium proper of large intestine" EXACT [] xref: FMA:263090 xref: FMA:263112 is_a: CL:0002071 ! enterocyte of epithelium of large intestine [Term] id: CL:1000347 name: vacuolar absorptive cell of epithelium of colon namespace: cell def: "A columnar cell of the colon that is part of the colonic epithelium." [GOC:tfm] xref: FMA:263114 is_a: CL:0002071 {is_inferred="true"} ! enterocyte of epithelium of large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine intersection_of: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0000397 ! colonic epithelium [Term] id: CL:1000348 name: basal cell of epithelium of trachea namespace: cell def: "A basal cell that is part of the epithelium of trachea." [GOC:tfm] xref: FMA:263118 is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea [Term] id: CL:1000349 name: basal cell of epithelium of bronchus namespace: cell alt_id: CL:0002331 def: "A basal cell found in the bronchus epithelium." [GOC:tfm] synonym: "basal cell of bronchus" EXACT [] xref: FMA:263120 is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree is_a: CL:0002633 ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus [Term] id: CL:1000350 name: basal cell of epithelium of terminal bronchiole namespace: cell def: "A basal cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] xref: FMA:263122 is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001958 ! epithelium of terminal bronchiole relationship: part_of UBERON:0001958 ! epithelium of terminal bronchiole [Term] id: CL:1000351 name: basal cell of epithelium of respiratory bronchiole namespace: cell def: "A basal cell that is part of the epithelium of respiratory bronchiole." [GOC:tfm] xref: FMA:263124 is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole [Term] id: CL:1000352 name: basal cell of epithelium of lobular bronchiole namespace: cell def: "A basal cell that is part of the epithelium of bronchiole." [GOC:tfm] xref: FMA:263126 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:1000349 ! basal cell of epithelium of bronchus intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole [Term] id: CL:1000353 name: microfold cell of epithelium of small intestine namespace: cell def: "A M cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263128 is_a: CL:0000682 {is_inferred="true"} ! M cell of gut is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000354 name: microfold cell of epithelium of intestinal villus namespace: cell def: "A M cell that is part of the epithelium of intestinal villus." [GOC:tfm] xref: FMA:263130 is_a: CL:1000353 ! microfold cell of epithelium of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000355 name: microfold cell of epithelium proper of small intestine namespace: cell def: "A M cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263132 is_a: CL:1000353 ! microfold cell of epithelium of small intestine [Term] id: CL:1000356 name: microfold cell of epithelium proper of duodenum namespace: cell def: "A M cell that is part of the epithelium proper of duodenum." [GOC:tfm] xref: FMA:263134 is_a: CL:1000354 ! microfold cell of epithelium of intestinal villus intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1000357 name: microfold cell of epithelium proper of jejunum namespace: cell def: "A M cell that is part of the epithelium proper of jejunum." [GOC:tfm] xref: FMA:263136 is_a: CL:1000353 ! microfold cell of epithelium of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000358 name: microfold cell of epithelium proper of ileum namespace: cell def: "A M cell that is part of the epithelium proper of ileum." [GOC:tfm] xref: FMA:263138 is_a: CL:1000353 ! microfold cell of epithelium of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: CL:1000359 name: microfold cell of epithelium proper of appendix namespace: cell def: "A M cell that is part of the epithelium proper of appendix." [GOC:tfm] xref: FMA:263140 is_a: CL:1000360 ! microfold cell of epithelium proper of large intestine is_a: CL:1000405 ! epithelial cell of appendix is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0009697 ! epithelium of appendix intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: CL:1000360 name: microfold cell of epithelium proper of large intestine namespace: cell def: "A M cell that is part of the epithelium proper of large intestine." [GOC:tfm] xref: FMA:263142 is_a: CL:0000682 ! M cell of gut is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine [Term] id: CL:1000361 name: transitional myocyte of interatrial septum namespace: cell def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] xref: FMA:263152 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002085 ! interatrial septum relationship: part_of UBERON:0002085 ! interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum namespace: cell def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263154 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000363 name: transitional myocyte of atrial branch of anterior internodal tract namespace: cell def: "A transitional myocyte that is part of the atrial branch of anterior internodal tract." [GOC:tfm] xref: FMA:263156 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000364 name: transitional myocyte of anterior internodal tract namespace: cell def: "A transitional myocyte that is part of the anterior internodal tract." [GOC:tfm] xref: FMA:263158 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000365 name: transitional myocyte of atrial septal branch of anterior internodal tract namespace: cell def: "A transitional myocyte that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm] xref: FMA:263160 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000366 name: transitional myocyte of middle internodal tract namespace: cell def: "A transitional myocyte that is part of the middle internodal tract." [GOC:tfm] xref: FMA:263162 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000367 name: transitional myocyte of posterior internodal tract namespace: cell def: "A transitional myocyte that is part of the posterior internodal tract." [GOC:tfm] xref: FMA:263164 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000368 name: transitional myocyte of anterior division of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263166 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000369 name: transitional myocyte of septal division of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263168 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000370 name: transitional myocyte of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263170 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0005986 ! left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000371 name: transitional myocyte of right branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the right branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263172 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0005987 ! right branch of atrioventricular bundle relationship: part_of UBERON:0005987 ! right branch of atrioventricular bundle [Term] id: CL:1000372 name: transitional myocyte of atrial part of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the atrial part of atrioventricular bundle." [GOC:tfm] xref: FMA:263174 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle [Term] id: CL:1000373 name: transitional myocyte of ventricular part of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the ventricular part of atrioventricular bundle." [GOC:tfm] xref: FMA:263176 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle [Term] id: CL:1000374 name: transitional myocyte of posterior division of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263178 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000375 name: myocardial endocrine cell of septal division of left branch of atrioventricular bundle namespace: cell def: "A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263180 is_a: CL:0002074 ! myocardial endocrine cell relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000376 name: purkinje myocyte of interventricular septum namespace: cell def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263182 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000377 name: dense-core granulated cell of epithelium of trachea namespace: cell def: "A Feyrter cell that is part of the epithelium of trachea." [GOC:tfm] xref: FMA:263184 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002066 {is_inferred="true"} ! Feyrter cell intersection_of: CL:0002066 ! Feyrter cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea [Term] id: CL:1000378 name: type 1 vestibular sensory cell of stato-acoustic epithelium namespace: cell def: "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm] xref: FMA:263186 is_a: CL:0002070 {is_inferred="true"} ! type I vestibular sensory cell intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: part_of UBERON:0009969 ! stato-acoustic epithelium relationship: part_of UBERON:0009969 ! stato-acoustic epithelium [Term] id: CL:1000379 name: type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth namespace: cell def: "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm] xref: FMA:263188 is_a: CL:0002070 ! type I vestibular sensory cell relationship: part_of UBERON:0003241 ! epithelium of utricle [Term] id: CL:1000380 name: type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth namespace: cell def: "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm] xref: FMA:263190 is_a: CL:0002070 ! type I vestibular sensory cell relationship: part_of UBERON:0003242 ! epithelium of saccule [Term] id: CL:1000381 name: type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth namespace: cell def: "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm] xref: FMA:263192 is_a: CL:0002070 {is_inferred="true"} ! type I vestibular sensory cell intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium [Term] id: CL:1000382 name: type 2 vestibular sensory cell of stato-acoustic epithelium namespace: cell def: "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm] xref: FMA:263194 is_a: CL:0002069 {is_inferred="true"} ! type II vestibular sensory cell intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: part_of UBERON:0009969 ! stato-acoustic epithelium relationship: part_of UBERON:0009969 ! stato-acoustic epithelium [Term] id: CL:1000383 name: type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth namespace: cell def: "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm] xref: FMA:263196 is_a: CL:0002069 ! type II vestibular sensory cell relationship: part_of UBERON:0003241 ! epithelium of utricle [Term] id: CL:1000384 name: type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth namespace: cell def: "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm] xref: FMA:263198 is_a: CL:0002069 ! type II vestibular sensory cell relationship: part_of UBERON:0003242 ! epithelium of saccule [Term] id: CL:1000385 name: type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth namespace: cell def: "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm] xref: FMA:263200 is_a: CL:0002069 {is_inferred="true"} ! type II vestibular sensory cell intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium [Term] id: CL:1000391 name: melanocyte of eyelid namespace: cell def: "A melanocyte that is part of the eyelid." [GOC:tfm] synonym: "eyelid melanocyte" EXACT [FMA:59175] synonym: "sebaceous gland of wolff" EXACT [FMA:59175] xref: FMA:59175 is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: CL:1000394 name: myoepithelial cell of intralobular lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct." [GOC:tfm] xref: FMA:62158 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000397 name: endothelial cell of venous sinus of red pulp of spleen namespace: cell def: "An endothelial cell that is part of the venous sinus of red pulp of spleen." [GOC:tfm] comment: todo - add logical definition to UBERON:0009967 xref: FMA:62817 is_a: CL:0002651 ! endothelial cell of venous sinus of spleen intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0009967 ! spleen venous sinus relationship: part_of UBERON:0009967 ! spleen venous sinus [Term] id: CL:1000398 name: endothelial cell of hepatic sinusoid namespace: cell def: "An endothelial cell that is part of the hepatic sinusoid." [GOC:tfm] synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911] xref: FMA:62911 is_a: CL:0000182 ! hepatocyte is_a: CL:0002262 {is_inferred="true"} ! endothelial cell of sinusoid intersection_of: CL:0002262 ! endothelial cell of sinusoid intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: part_of UBERON:0001281 ! hepatic sinusoid [Term] id: CL:1000405 name: epithelial cell of appendix namespace: cell def: "An epithelial cell that is part of the appendix." [GOC:tfm] synonym: "columnar epitheliocyte of appendix" EXACT [FMA:63602] synonym: "epithelial cell of vermiform appendix" EXACT [FMA:63602] xref: FMA:63602 is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: CL:1000409 name: myocyte of sinoatrial node namespace: cell def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] synonym: "myocyte of sinoatrial node" EXACT [FMA:67102] synonym: "SA nodal myocyte" EXACT [FMA:67102] synonym: "SA node cardiac muscle cell" EXACT [GOC:pr] synonym: "sinoatrial node cell" EXACT [GOC:pr] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [FMA:67102] xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002351 ! sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node namespace: cell def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] synonym: "atrioventricular node cell" EXACT [GOC:pr] synonym: "atrioventricular node myocyte" EXACT [FMA:67106] synonym: "AV nodal myocyte" EXACT [FMA:67106] synonym: "AV node cardiac muscle cell" EXACT [GOC:pr] synonym: "AV node cell" EXACT [GOC:pr] xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002352 ! atrioventricular node relationship: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000411 name: endothelial cell of peyer's patch namespace: cell def: "An endothelial cell that is part of the small intestine Peyer's patch." [GOC:tfm] xref: FMA:67757 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003454 ! small intestine Peyer's patch relationship: part_of UBERON:0003454 ! small intestine Peyer's patch [Term] id: CL:1000412 name: endothelial cell of arteriole namespace: cell def: "An endothelial cell that is part of the arteriole." [GOC:tfm] xref: FMA:67760 xref: KUPO:0001097 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole [Term] id: CL:1000413 name: endothelial cell of artery namespace: cell alt_id: CL:0002542 def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001917 ! endothelium of artery [Term] id: CL:1000414 name: endothelial cell of venule namespace: cell def: "An endothelial cell that is part of the venule." [GOC:tfm] xref: FMA:67762 is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule [Term] id: CL:1000415 name: epithelial cell of gall bladder namespace: cell def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] xref: FMA:67780 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: CL:1000416 name: myoepithelial cell of lactiferous gland namespace: cell def: "A myoepithelial cell that is part of the mammary gland." [GOC:tfm] synonym: "basal cell of lactiferous duct" EXACT [FMA:67800] xref: CALOHA:TS-2378 xref: FMA:67800 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: CL:1000417 name: myoepithelial cell of sweat gland namespace: cell def: "A myoepithelial cell that is part of the sweat gland." [GOC:tfm] xref: FMA:67801 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001820 ! sweat gland relationship: part_of UBERON:0001820 ! sweat gland [Term] id: CL:1000418 name: myoepithelial cell of lactiferous alveolus namespace: cell def: "A myoepithelial cell that is part of the mammary gland alveolus." [GOC:tfm] synonym: "basal cell of alveolus of lactiferous gland" EXACT [FMA:67802] synonym: "myoepithelial cell of mammary alveolus" EXACT [FMA:67802] xref: FMA:67802 is_a: CL:1000416 ! myoepithelial cell of lactiferous gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0003214 ! mammary gland alveolus relationship: part_of UBERON:0003214 ! mammary gland alveolus [Term] id: CL:1000419 name: myoepithelial cell of lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the lactiferous duct." [GOC:tfm] xref: FMA:67803 is_a: CL:0000068 ! duct epithelial cell is_a: CL:1000416 ! myoepithelial cell of lactiferous gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001765 ! mammary duct relationship: part_of UBERON:0001765 ! mammary duct [Term] id: CL:1000420 name: myoepithelial cell of terminal lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the terminal lactiferous duct." [GOC:tfm] xref: FMA:67804 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000424 name: chromaffin cell of paraaortic body namespace: cell def: "A chromaffin cell that is part of the paraaortic body." [GOC:tfm] synonym: "chromaffin cell of para-aortic body" EXACT [FMA:69328] xref: FMA:69328 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001237 ! paraaortic body relationship: part_of UBERON:0001237 ! paraaortic body [Term] id: CL:1000425 name: chromaffin cell of paraganglion namespace: cell def: "A chromaffin cell that is part of the paraganglion." [GOC:tfm] xref: FMA:69335 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0012279 ! paraganglion relationship: part_of UBERON:0012279 ! paraganglion [Term] id: CL:1000426 name: chromaffin cell of adrenal gland namespace: cell def: "A chromaffin cell that is part of the adrenal gland." [GOC:tfm] xref: FMA:69794 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002369 ! adrenal gland relationship: part_of UBERON:0002369 ! adrenal gland [Term] id: CL:1000427 name: adrenal cortex chromaffin cell namespace: cell def: "A chromaffin cell that is part of the adrenal cortex." [GOC:tfm] comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin. synonym: "chromaffin cell of adrenal cortex" EXACT [] xref: FMA:69795 is_a: CL:1000426 ! chromaffin cell of adrenal gland is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: CL:1000428 name: stem cell of epidermis namespace: cell def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis [Term] id: CL:1000432 name: conjunctival epithelial cell namespace: cell def: "An epithelial cell that is part of the conjunctiva." [GOC:tfm] synonym: "epithelial cell of conjunctiva" EXACT [FMA:70552] xref: FMA:70552 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva [Term] id: CL:1000433 name: epithelial cell of lacrimal canaliculus namespace: cell def: "An epithelial cell that is part of the lacrimal canaliculus." [GOC:tfm] xref: FMA:70553 is_a: CL:0000068 ! duct epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001770 ! lacrimal canaliculus relationship: part_of UBERON:0001770 ! lacrimal canaliculus [Term] id: CL:1000434 name: epithelial cell of external acoustic meatus namespace: cell def: "An epithelial cell that is part of the external acoustic meatus." [GOC:tfm] xref: FMA:70555 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001352 ! external acoustic meatus relationship: part_of UBERON:0001352 ! external acoustic meatus [Term] id: CL:1000435 name: epithelial cell of lacrimal duct namespace: cell def: "An epithelial cell that is part of the lacrimal duct." [GOC:tfm] xref: FMA:70559 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0001850 ! lacrimal duct relationship: part_of UBERON:0001850 ! lacrimal duct [Term] id: CL:1000436 name: epithelial cell of lacrimal sac namespace: cell def: "An epithelial cell that is part of the lacrimal sac." [GOC:tfm] xref: FMA:70560 is_a: CL:0000068 ! duct epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001351 ! lacrimal sac relationship: part_of UBERON:0001351 ! lacrimal sac [Term] id: CL:1000437 name: epithelial cell of nasolacrimal duct namespace: cell def: "An epithelial cell that is part of the nasolacrimal duct." [GOC:tfm] xref: FMA:70561 is_a: CL:1000435 ! epithelial cell of lacrimal duct intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0002392 ! nasolacrimal duct relationship: part_of UBERON:0002392 ! nasolacrimal duct [Term] id: CL:1000438 name: epithelial cell of wall of inferior part of anal canal namespace: cell def: "An epithelial cell that is part of the wall of inferior part of anal canal." [GOC:tfm] xref: FMA:70562 is_a: CL:0002634 ! epithelial cell of anal column [Term] id: CL:1000441 name: epithelial cell of viscerocranial mucosa namespace: cell def: "An epithelial cell that is part of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70583 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:1000442 name: urothelial cell of trigone of urinary bladder namespace: cell def: "An urothelial cell that is part of the trigone of urinary bladder." [GOC:tfm] synonym: "epithelial cell of vesical trigone" EXACT [FMA:70598] xref: FMA:70598 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder relationship: part_of UBERON:0001257 ! trigone of urinary bladder [Term] id: CL:1000443 name: ciliary muscle cell namespace: cell def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610] xref: FMA:70610 is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001775 ! ciliary body relationship: part_of UBERON:0001775 ! ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye namespace: cell def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] xref: FMA:70615 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 ! anterior chamber of eyeball [Term] id: CL:1000445 name: myoepithelial cell of dilator pupillae namespace: cell def: "A myoepithelial cell that is part of the dilatator pupillae." [GOC:tfm] xref: FMA:70619 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001608 ! dilatator pupillae relationship: part_of UBERON:0001608 ! dilatator pupillae [Term] id: CL:1000447 name: epithelial cell of stratum germinativum of esophagus namespace: cell def: "A basal cell that is part of the epithelium of esophagus." [GOC:tfm] synonym: "basal cell of esophageal epithelium" EXACT [FMA:70731] xref: FMA:70731 is_a: CL:0000646 {is_inferred="true"} ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001976 ! epithelium of esophagus relationship: part_of UBERON:0001976 ! epithelium of esophagus [Term] id: CL:1000448 name: epithelial cell of sweat gland namespace: cell def: "An epithelial cell that is part of the sweat gland." [GOC:tfm] xref: FMA:70952 is_a: CL:0000362 ! epidermal cell is_a: CL:0002308 ! epithelial cell of skin gland intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001820 ! sweat gland relationship: part_of UBERON:0001820 ! sweat gland [Term] id: CL:1000449 name: epithelial cell of nephron namespace: cell def: "An epithelial cell that is part of the nephron." [GOC:tfm] xref: FMA:70965 is_a: CL:0002518 ! kidney epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001285 ! nephron relationship: part_of UBERON:0001285 ! nephron [Term] id: CL:1000450 name: epithelial cell of glomerular capsule namespace: cell def: "An epithelial cell that is part of the glomerular capsule." [GOC:tfm] synonym: "Bowmans capsule epithelial cell" EXACT [] synonym: "epithelial cell of Bowman's capsule" EXACT [FMA:70966] xref: FMA:70966 xref: KUPO:0001034 is_a: CL:1000510 ! kidney glomerular epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001230 ! glomerular capsule relationship: part_of UBERON:0001230 ! glomerular capsule [Term] id: CL:1000451 name: epithelial cell of visceral layer of glomerular capsule namespace: cell def: "An epithelial cell that is part of the visceral layer of glomerular capsule." [GOC:tfm] comment: consider merging into CL:0000653 synonym: "glomerular podocyte" NARROW [FMA:70967] xref: FMA:70967 is_a: CL:1000450 ! epithelial cell of glomerular capsule intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005751 ! visceral layer of glomerular capsule relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule [Term] id: CL:1000452 name: parietal epithelial cell namespace: cell alt_id: CL:1000897 def: "An epithelial cell that is part of the glomerular parietal epithelium." [GOC:tfm] synonym: "epithelial cell of parietal layer of glomerular capsule" EXACT [FMA:70968] xref: FMA:70968 xref: KUPO:0001035 is_a: CL:1000450 ! epithelial cell of glomerular capsule intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005750 ! glomerular parietal epithelium relationship: part_of UBERON:0005750 ! glomerular parietal epithelium [Term] id: CL:1000453 name: epithelial cell of intermediate tubule namespace: cell def: "An epithelial cell that is part of the intermediate tubule." [GOC:tfm] xref: FMA:70980 is_a: CL:1000909 ! kidney loop of henle epithelial cell intersection_of: CL:1000494 ! epithelial cell of renal tubule intersection_of: part_of UBERON:0004136 ! intermediate tubule relationship: part_of UBERON:0004136 ! intermediate tubule [Term] id: CL:1000454 name: kidney collecting duct epithelial cell namespace: cell def: "An epithelial cell that is part of the collecting duct of renal tubule." [GOC:tfm] synonym: "epithelial cell of renal collecting tubule" EXACT [FMA:70982] xref: FMA:70982 xref: KUPO:0001059 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum namespace: cell def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001366 ! parietal peritoneum relationship: part_of UBERON:0001366 ! parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum namespace: cell def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001178 ! visceral peritoneum relationship: part_of UBERON:0001178 ! visceral peritoneum [Term] id: CL:1000458 name: melanocyte of skin namespace: cell def: "A melanocyte that is part of the skin of body." [GOC:tfm] synonym: "skin melanocyte" EXACT [FMA:72144] xref: CALOHA:TS-2374 xref: FMA:72144 is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body [Term] id: CL:1000465 name: chromaffin cell of ovary namespace: cell def: "A chromaffin cell that is part of the ovary." [GOC:tfm] xref: FMA:74319 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: CL:1000466 name: chromaffin cell of right ovary namespace: cell def: "A chromaffin cell that is part of the right ovary." [GOC:tfm] xref: FMA:74320 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002118 ! right ovary relationship: part_of UBERON:0002118 ! right ovary [Term] id: CL:1000467 name: chromaffin cell of left ovary namespace: cell def: "A chromaffin cell that is part of the left ovary." [GOC:tfm] xref: FMA:74321 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002119 ! left ovary relationship: part_of UBERON:0002119 ! left ovary [Term] id: CL:1000468 name: myoepithelial cell of acinus of lactiferous gland namespace: cell def: "A myoepithelial cell that is part of the acinus of lactiferous gland." [GOC:tfm] synonym: "basal cell of acinus of lactiferous gland" EXACT [FMA:74469] xref: FMA:74469 is_a: CL:1000416 ! myoepithelial cell of lactiferous gland relationship: part_of UBERON:0001912 ! lobule of lactiferous gland [Term] id: CL:1000469 name: myoepithelial cell of main lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the main lactiferous duct." [GOC:tfm] xref: FMA:74499 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000470 name: myoepithelial cell of primary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the primary lactiferous duct." [GOC:tfm] xref: FMA:74500 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000471 name: myoepithelial cell of secondary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the secondary lactiferous duct." [GOC:tfm] xref: FMA:74501 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000472 name: myoepithelial cell of tertiary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the tertiary lactiferous duct." [GOC:tfm] xref: FMA:74502 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000473 name: myoepithelial cell of quarternary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the quarternary lactiferous duct." [GOC:tfm] xref: FMA:74503 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000477 name: cardiac pacemaker cell of sinoatrial node namespace: cell def: "A nodal myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "cardiac pacemaker cell of sinuatrial node" EXACT [] synonym: "pacemaker cell of sinoatrial node" EXACT [] synonym: "pacemaker cell of sinuatrial node" EXACT [] xref: FMA:83383 is_a: CL:1000409 ! myocyte of sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node namespace: cell def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002351 ! sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000479 name: purkinje myocyte of atrioventricular node namespace: cell def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] xref: FMA:83386 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002352 ! atrioventricular node relationship: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000480 name: transitional myocyte of internodal tract namespace: cell def: "A transitional myocyte that is part of the internodal tract." [GOC:tfm] xref: FMA:83387 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:0002096 ! internodal tract myocyte intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract [Term] id: CL:1000481 name: transitional myocyte of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the atrioventricular bundle." [GOC:tfm] xref: FMA:83388 xref: FMA:83885 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:0010005 ! atrioventricular bundle cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002353 ! atrioventricular bundle relationship: part_of UBERON:0002353 ! atrioventricular bundle [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum namespace: cell def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] xref: FMA:83390 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000483 name: purkinje myocyte of internodal tract namespace: cell def: "A Purkinje myocyte that is part of the internodal tract." [GOC:tfm] xref: FMA:83392 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:0002096 ! internodal tract myocyte intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract [Term] id: CL:1000484 name: purkinje myocyte of atrioventricular bundle namespace: cell def: "A Purkinje myocyte that is part of the atrioventricular bundle." [GOC:tfm] xref: FMA:83393 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:0010005 ! atrioventricular bundle cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002353 ! atrioventricular bundle relationship: part_of UBERON:0002353 ! atrioventricular bundle [Term] id: CL:1000486 name: basal cell of urothelium namespace: cell def: "A basal cell that is part of the urothelium." [GOC:tfm] xref: FMA:84150 is_a: CL:0000646 {is_inferred="true"} ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0000365 ! urothelium relationship: part_of UBERON:0000365 ! urothelium [Term] id: CL:1000487 name: smooth muscle cell of prostate namespace: cell def: "A smooth muscle cell that is part of the prostate gland." [GOC:tfm] synonym: "smooth muscle fiber of prostate" EXACT [FMA:84583] xref: FMA:84583 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000488 name: cholangiocyte namespace: cell def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] synonym: "epithelial cell of bile duct" EXACT [] xref: FMA:86481 is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: part_of UBERON:0002394 ! bile duct intersection_of: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002394 ! bile duct relationship: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity [Term] id: CL:1000489 name: reticular cell of splenic cord namespace: cell def: "A reticular cell that is part of the splenic cord." [GOC:tfm] xref: FMA:86497 is_a: CL:0000432 {is_inferred="true"} ! reticular cell intersection_of: CL:0000432 ! reticular cell intersection_of: part_of UBERON:0001266 ! splenic cord relationship: part_of UBERON:0001266 ! splenic cord [Term] id: CL:1000490 name: mesothelial cell of peritoneum namespace: cell def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] synonym: "peritoneal mesothelial cell" EXACT [FMA:86736] xref: FMA:86736 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002358 ! peritoneum relationship: part_of UBERON:0002358 ! peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura namespace: cell def: "A mesothelial cell that is part of the pleura." [GOC:tfm] synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura namespace: cell def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002400 ! parietal pleura relationship: part_of UBERON:0002400 ! parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura namespace: cell def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] xref: FMA:86739 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002401 ! visceral pleura relationship: part_of UBERON:0002401 ! visceral pleura [Term] id: CL:1000494 name: epithelial cell of renal tubule namespace: cell def: "An epithelial cell that is part of the renal tubule." [GOC:tfm] synonym: "kidney tubule epithelial cell" EXACT [] xref: FMA:86785 xref: KUPO:0001022 is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1000507 {is_inferred="true"} ! kidney tubule cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0004810 ! nephron tubule epithelium [Term] id: CL:1000495 name: small intestine goblet cell namespace: cell def: "A goblet cell that is part of the small intestine." [GOC:tfm] synonym: "goblet cell of epithelium of small intestine" EXACT [] synonym: "goblet cell of small intestine" EXACT [] synonym: "small intestinal goblet cell" EXACT [FMA:86929] xref: FMA:86929 is_a: CL:0000160 ! goblet cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000497 name: kidney cell namespace: cell xref: KUPO:0001010 is_a: CL:0000548 {is_inferred="true"} ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1000500 name: kidney interstitial cell namespace: cell xref: KUPO:0001013 is_a: CL:0002320 ! connective tissue cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005215 ! kidney interstitium relationship: part_of UBERON:0005215 ! kidney interstitium [Term] id: CL:1000504 name: kidney medulla cell namespace: cell xref: KUPO:0001017 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla [Term] id: CL:1000505 name: kidney pelvis cell namespace: cell xref: KUPO:0001018 is_a: CL:1000497 {is_inferred="true"} ! kidney cell is_a: CL:1000601 ! ureteral cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis [Term] id: CL:1000507 name: kidney tubule cell namespace: cell xref: KUPO:0001020 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0001231 ! nephron tubule [Term] id: CL:1000510 name: kidney glomerular epithelial cell namespace: cell xref: KUPO:0001023 is_a: CL:1000746 ! glomerular cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0004188 ! glomerular epithelium relationship: part_of UBERON:0004188 ! glomerular epithelium [Term] id: CL:1000546 name: kidney medulla collecting duct epithelial cell namespace: cell xref: KUPO:0001060 is_a: CL:1000504 ! kidney medulla cell is_a: CL:1001225 ! kidney collecting duct cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005185 ! renal medulla collecting duct relationship: part_of UBERON:0005185 ! renal medulla collecting duct [Term] id: CL:1000547 name: kidney inner medulla collecting duct epithelial cell namespace: cell xref: KUPO:0001061 is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell is_a: CL:1000617 ! kidney inner medulla cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005187 ! inner renal medulla collecting duct relationship: part_of UBERON:0005187 ! inner renal medulla collecting duct [Term] id: CL:1000548 name: kidney outer medulla collecting duct epithelial cell namespace: cell xref: KUPO:0001062 is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell is_a: CL:1000616 ! kidney outer medulla cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005186 ! outer renal medulla collecting duct relationship: part_of UBERON:0005186 ! outer renal medulla collecting duct [Term] id: CL:1000549 name: kidney cortex collecting duct epithelial cell namespace: cell xref: KUPO:0001063 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1001225 ! kidney collecting duct cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005267 ! renal cortex collecting duct relationship: part_of UBERON:0005267 ! renal cortex collecting duct [Term] id: CL:1000550 name: kidney papillary duct principal epithelial cell namespace: cell xref: KUPO:0001064 is_a: CL:1001225 ! kidney collecting duct cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005167 ! papillary duct relationship: part_of UBERON:0005167 ! papillary duct [Term] id: CL:1000596 name: inner renal cortex cell namespace: cell xref: KUPO:0001111 is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005271 ! juxtamedullary cortex relationship: part_of UBERON:0005271 ! juxtamedullary cortex [Term] id: CL:1000597 name: papillary tips cell namespace: cell xref: KUPO:0001112 is_a: CL:1000505 ! kidney pelvis cell is_a: CL:1000617 ! kidney inner medulla cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0009095 ! tip of renal papilla relationship: part_of UBERON:0009095 ! tip of renal papilla [Term] id: CL:1000600 name: lower urinary tract cell namespace: cell xref: KUPO:0001115 is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001556 ! lower urinary tract relationship: part_of UBERON:0001556 ! lower urinary tract [Term] id: CL:1000601 name: ureteral cell namespace: cell xref: KUPO:0001116 is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter [Term] id: CL:1000606 name: kidney nerve cell namespace: cell xref: KUPO:0001015 is_a: CL:0000540 ! neuron is_a: CL:1000500 ! kidney interstitial cell intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1000612 name: kidney corpuscule cell namespace: cell xref: KUPO:0001021 is_a: CL:0002584 {is_inferred="true"} ! renal cortical epithelial cell is_a: CL:1000449 ! epithelial cell of nephron intersection_of: CL:0002584 ! renal cortical epithelial cell intersection_of: part_of UBERON:0001229 ! renal corpuscle relationship: part_of UBERON:0001229 ! renal corpuscle [Term] id: CL:1000615 name: kidney cortex tubule cell namespace: cell xref: KUPO:0001024 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000494 ! epithelial cell of renal tubule intersection_of: CL:1000507 ! kidney tubule cell intersection_of: part_of UBERON:0006853 ! renal cortex tubule relationship: part_of UBERON:0006853 ! renal cortex tubule [Term] id: CL:1000616 name: kidney outer medulla cell namespace: cell xref: KUPO:0001025 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: CL:1000617 name: kidney inner medulla cell namespace: cell xref: KUPO:0001026 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: CL:1000618 name: juxtaglomerular complex cell namespace: cell xref: KUPO:0001028 is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell intersection_of: CL:0002681 ! kidney cortical cell intersection_of: part_of UBERON:0002303 ! juxtaglomerular apparatus relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus [Term] id: CL:1000681 name: kidney cortex interstitial cell namespace: cell xref: KUPO:0001091 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell intersection_of: CL:1000500 ! kidney interstitial cell intersection_of: part_of UBERON:0005270 ! renal cortex interstitium relationship: part_of UBERON:0005270 ! renal cortex interstitium [Term] id: CL:1000682 name: kidney medulla interstitial cell namespace: cell xref: KUPO:0001092 is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000500 ! kidney interstitial cell intersection_of: part_of UBERON:0005211 ! renal medulla interstitium relationship: part_of UBERON:0005211 ! renal medulla interstitium [Term] id: CL:1000691 name: kidney interstitial myofibroblast namespace: cell xref: KUPO:0001101 is_a: CL:0000186 ! myofibroblast cell is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000692 name: kidney interstitial fibroblast namespace: cell xref: KUPO:0001102 is_a: CL:0000057 ! fibroblast is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000693 name: kidney interstitial fibrocyte namespace: cell xref: KUPO:0001103 is_a: CL:0000135 ! fibrocyte is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000695 name: kidney interstitial alternatively activated macrophage namespace: cell xref: KUPO:0001106 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0000890 ! alternatively activated macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000696 name: kidney interstitial inflammatory macrophage namespace: cell xref: KUPO:0001107 is_a: CL:0000863 ! inflammatory macrophage is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000697 name: kidney interstitial suppressor macrophage namespace: cell xref: KUPO:0001108 is_a: CL:0000862 ! suppressor macrophage is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000698 name: kidney resident macrophage namespace: cell xref: KUPO:0001109 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000699 name: kidney resident dendritic cell namespace: cell xref: KUPO:0001110 is_a: CL:0001007 ! interstitial dendritic cell is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000702 name: kidney pelvis smooth muscle cell namespace: cell xref: KUPO:0001113 is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell is_a: CL:1000979 ! ureter smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004227 ! kidney pelvis smooth muscle relationship: part_of UBERON:0004227 ! kidney pelvis smooth muscle [Term] id: CL:1000703 name: kidney pelvis urothelial cell namespace: cell xref: KUPO:0001114 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell is_a: CL:1000706 ! ureter urothelial cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0004788 ! kidney pelvis urothelium relationship: part_of UBERON:0004788 ! kidney pelvis urothelium [Term] id: CL:1000706 name: ureter urothelial cell namespace: cell xref: KUPO:0001117 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1000319 ! ureter epithelial cell intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0001254 ! urothelium of ureter relationship: part_of UBERON:0001254 ! urothelium of ureter [Term] id: CL:1000708 name: ureter adventitial cell namespace: cell xref: KUPO:0001119 is_a: CL:0000115 ! endothelial cell is_a: CL:0000134 ! mesenchymal cell is_a: CL:0002503 ! adventitial cell is_a: CL:1000319 ! ureter epithelial cell intersection_of: CL:1000601 ! ureteral cell intersection_of: part_of UBERON:0001252 ! adventitia of ureter relationship: part_of UBERON:0001252 ! adventitia of ureter [Term] id: CL:1000714 name: kidney cortex collecting duct principal cell namespace: cell xref: KUPO:0001130 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005267 ! renal cortex collecting duct relationship: part_of UBERON:0005267 ! renal cortex collecting duct [Term] id: CL:1000715 name: kidney cortex collecting duct intercalated cell namespace: cell xref: KUPO:0001131 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005267 ! renal cortex collecting duct relationship: part_of UBERON:0005267 ! renal cortex collecting duct [Term] id: CL:1000716 name: kidney outer medulla collecting duct principal cell namespace: cell xref: KUPO:0001132 is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005186 ! outer renal medulla collecting duct relationship: part_of UBERON:0005186 ! outer renal medulla collecting duct [Term] id: CL:1000717 name: kidney outer medulla collecting duct intercalated cell namespace: cell xref: KUPO:0001133 is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005186 ! outer renal medulla collecting duct relationship: part_of UBERON:0005186 ! outer renal medulla collecting duct [Term] id: CL:1000718 name: kidney inner medulla collecting duct principal cell namespace: cell xref: KUPO:0001134 is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005187 ! inner renal medulla collecting duct relationship: part_of UBERON:0005187 ! inner renal medulla collecting duct [Term] id: CL:1000719 name: kidney inner medulla collecting duct intercalated cell namespace: cell xref: KUPO:0001135 is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005187 ! inner renal medulla collecting duct relationship: part_of UBERON:0005187 ! inner renal medulla collecting duct [Term] id: CL:1000720 name: kidney papillary duct intercalated cell namespace: cell xref: KUPO:0001136 is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005167 ! papillary duct relationship: part_of UBERON:0005167 ! papillary duct [Term] id: CL:1000721 name: kidney papillary duct principal cell namespace: cell xref: KUPO:0001137 is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005167 ! papillary duct relationship: part_of UBERON:0005167 ! papillary duct [Term] id: CL:1000742 name: glomerular mesangial cell namespace: cell def: "Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney." [Wikipedia:Intraglomerular_mesangial_cell] synonym: "intraglomerular mesangial cell" EXACT [CL:cjm] xref: KUPO:0001032 is_a: CL:0000650 ! mesangial cell is_a: CL:1000500 ! kidney interstitial cell is_a: CL:1000746 ! glomerular cell is_a: CL:1001318 ! renal interstitial pericyte intersection_of: CL:1000612 ! kidney corpuscule cell intersection_of: part_of UBERON:0002320 ! glomerular mesangium relationship: part_of UBERON:0002320 ! glomerular mesangium [Term] id: CL:1000746 name: glomerular cell namespace: cell xref: KUPO:0001036 is_a: CL:1000612 {is_inferred="true"} ! kidney corpuscule cell intersection_of: CL:1000612 ! kidney corpuscule cell intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus [Term] id: CL:1000768 name: kidney connecting tubule epithelial cell namespace: cell xref: KUPO:0001058 is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:1000494 ! epithelial cell of renal tubule intersection_of: part_of UBERON:0005097 ! renal connecting tubule relationship: part_of UBERON:0005097 ! renal connecting tubule [Term] id: CL:1000803 name: kidney inner medulla interstitial cell namespace: cell xref: KUPO:0001093 is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell intersection_of: CL:1000682 ! kidney medulla interstitial cell intersection_of: part_of UBERON:0005214 ! inner renal medulla interstitium relationship: part_of UBERON:0005214 ! inner renal medulla interstitium [Term] id: CL:1000804 name: kidney outer medulla interstitial cell namespace: cell xref: KUPO:0001094 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell intersection_of: CL:1000682 ! kidney medulla interstitial cell intersection_of: part_of UBERON:0005213 ! outer renal medulla interstitium relationship: part_of UBERON:0005213 ! outer renal medulla interstitium [Term] id: CL:1000838 name: kidney proximal convoluted tubule epithelial cell namespace: cell xref: KUPO:0001045 is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: part_of UBERON:0001287 ! proximal convoluted tubule relationship: part_of UBERON:0001287 ! proximal convoluted tubule [Term] id: CL:1000839 name: kidney proximal straight tubule epithelial cell namespace: cell xref: KUPO:0001046 is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001021 ! kidney loop of henle descending limb epithelial cell intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: part_of UBERON:0001290 ! proximal straight tubule relationship: part_of UBERON:0001290 ! proximal straight tubule [Term] id: CL:1000849 name: kidney distal convoluted tubule epithelial cell namespace: cell xref: KUPO:0001056 is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: part_of UBERON:0001292 ! distal convoluted tubule relationship: part_of UBERON:0001292 ! distal convoluted tubule [Term] id: CL:1000850 name: macula densa epithelial cell namespace: cell xref: KUPO:0001057 is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: part_of UBERON:0002335 ! macula densa relationship: part_of UBERON:0002335 ! macula densa [Term] id: CL:1000854 name: kidney blood vessel cell namespace: cell xref: KUPO:0001014 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: part_of UBERON:0003517 ! kidney blood vessel relationship: part_of UBERON:0003517 ! kidney blood vessel relationship: participates_in GO:0008015 ! blood circulation [Term] id: CL:1000891 name: kidney arterial blood vessel cell namespace: cell xref: KUPO:0001029 is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: part_of UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0003644 ! kidney arterial blood vessel [Term] id: CL:1000892 name: kidney capillary endothelial cell namespace: cell xref: KUPO:0001030 is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:1000854 ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: part_of UBERON:0003527 ! kidney capillary relationship: part_of UBERON:0003527 ! kidney capillary [Term] id: CL:1000893 name: kidney venous blood vessel cell namespace: cell xref: KUPO:0001031 is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: part_of UBERON:0001140 ! renal vein relationship: part_of UBERON:0001140 ! renal vein [Term] id: CL:1000909 name: kidney loop of henle epithelial cell namespace: cell xref: KUPO:0001047 is_a: CL:1000494 {is_inferred="true"} ! epithelial cell of renal tubule intersection_of: CL:1000494 ! epithelial cell of renal tubule intersection_of: part_of UBERON:0001288 ! loop of Henle relationship: part_of UBERON:0001288 ! loop of Henle [Term] id: CL:1000979 name: ureter smooth muscle cell namespace: cell xref: KUPO:0001118 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1000601 {is_inferred="true"} ! ureteral cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0006855 ! ureter muscle layer relationship: part_of UBERON:0006855 ! ureter muscle layer [Term] id: CL:1001005 name: glomerular capillary endothelial cell namespace: cell xref: KUPO:0001037 is_a: CL:0002144 ! capillary endothelial cell is_a: CL:0002188 ! glomerular endothelial cell is_a: CL:1000510 ! kidney glomerular epithelial cell is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: part_of UBERON:0004294 ! glomerular capillary endothelium relationship: part_of UBERON:0004294 ! glomerular capillary endothelium [Term] id: CL:1001006 name: kidney afferent arteriole cell namespace: cell xref: KUPO:0001038 is_a: CL:1000612 ! kidney corpuscule cell is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: part_of UBERON:0004639 ! afferent arteriole relationship: part_of UBERON:0004639 ! afferent arteriole [Term] id: CL:1001009 name: kidney efferent arteriole cell namespace: cell xref: KUPO:0001041 is_a: CL:1000612 ! kidney corpuscule cell is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: part_of UBERON:0004640 ! efferent arteriole relationship: part_of UBERON:0004640 ! efferent arteriole [Term] id: CL:1001016 name: kidney loop of henle ascending limb epithelial cell namespace: cell xref: KUPO:0001048 is_a: CL:0002305 ! epithelial cell of distal tubule is_a: CL:1000909 {is_inferred="true"} ! kidney loop of henle epithelial cell intersection_of: CL:1000909 ! kidney loop of henle epithelial cell intersection_of: part_of UBERON:0005164 ! ascending limb of loop of Henle relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle [Term] id: CL:1001021 name: kidney loop of henle descending limb epithelial cell namespace: cell xref: KUPO:0001053 is_a: CL:1000909 {is_inferred="true"} ! kidney loop of henle epithelial cell intersection_of: CL:1000909 ! kidney loop of henle epithelial cell intersection_of: part_of UBERON:0001289 ! descending limb of loop of Henle relationship: part_of UBERON:0001289 ! descending limb of loop of Henle [Term] id: CL:1001033 name: peritubular capillary endothelial cell namespace: cell xref: KUPO:0001065 is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: part_of UBERON:0005272 ! peritubular capillary relationship: part_of UBERON:0005272 ! peritubular capillary [Term] id: CL:1001036 name: vasa recta cell namespace: cell xref: KUPO:0001068 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell is_a: CL:1000893 ! kidney venous blood vessel cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: part_of UBERON:0004726 ! vasa recta relationship: part_of UBERON:0004726 ! vasa recta [Term] id: CL:1001045 name: kidney cortex artery cell namespace: cell xref: KUPO:0001077 is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: part_of UBERON:0005268 ! renal cortex artery relationship: part_of UBERON:0005268 ! renal cortex artery [Term] id: CL:1001052 name: kidney cortex vein cell namespace: cell xref: KUPO:0001084 is_a: CL:1000893 {is_inferred="true"} ! kidney venous blood vessel cell intersection_of: CL:1000893 ! kidney venous blood vessel cell intersection_of: part_of UBERON:0005269 ! renal cortex vein relationship: part_of UBERON:0005269 ! renal cortex vein [Term] id: CL:1001064 name: kidney artery smooth muscle cell namespace: cell comment: Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure. xref: KUPO:0001096 is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:1000891 ! kidney arterial blood vessel cell [Term] id: CL:1001066 name: kidney arteriole smooth muscle cell namespace: cell comment: Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure. xref: KUPO:0001098 is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:1000891 ! kidney arterial blood vessel cell [Term] id: CL:1001068 name: kidney venous system smooth muscle cell namespace: cell comment: Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure. xref: KUPO:0001100 is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:1000893 ! kidney venous blood vessel cell [Term] id: CL:1001096 name: kidney afferent arteriole endothelial cell namespace: cell xref: KUPO:0001039 is_a: CL:1000412 {is_inferred="true"} ! endothelial cell of arteriole is_a: CL:1001006 ! kidney afferent arteriole cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004639 ! afferent arteriole relationship: part_of UBERON:0004639 ! afferent arteriole [Term] id: CL:1001097 name: kidney afferent arteriole smooth muscle cell namespace: cell xref: KUPO:0001040 is_a: CL:1001006 ! kidney afferent arteriole cell is_a: CL:1001066 ! kidney arteriole smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004639 ! afferent arteriole relationship: part_of UBERON:0004639 ! afferent arteriole [Term] id: CL:1001099 name: kidney efferent arteriole endothelial cell namespace: cell xref: KUPO:0001042 is_a: CL:1000412 {is_inferred="true"} ! endothelial cell of arteriole is_a: CL:1001009 ! kidney efferent arteriole cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004640 ! efferent arteriole relationship: part_of UBERON:0004640 ! efferent arteriole [Term] id: CL:1001100 name: kidney efferent arteriole smooth muscle cell namespace: cell xref: KUPO:0001043 is_a: CL:1001009 ! kidney efferent arteriole cell is_a: CL:1001066 ! kidney arteriole smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004640 ! efferent arteriole relationship: part_of UBERON:0004640 ! efferent arteriole [Term] id: CL:1001106 name: kidney loop of henle thick ascending limb epithelial cell namespace: cell xref: KUPO:0001049 is_a: CL:1000504 ! kidney medulla cell is_a: CL:1001016 {is_inferred="true"} ! kidney loop of henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0001291 ! thick ascending limb of loop of Henle relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle [Term] id: CL:1001107 name: kidney loop of henle thin ascending limb epithelial cell namespace: cell xref: KUPO:0001050 is_a: CL:1000617 ! kidney inner medulla cell is_a: CL:1001016 {is_inferred="true"} ! kidney loop of henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment relationship: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment [Term] id: CL:1001108 name: kidney loop of henle medullary thick ascending limb epithelial cell namespace: cell xref: KUPO:0001051 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001106 ! kidney loop of henle thick ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0006376 ! premacula segment of distal straight tubule relationship: part_of UBERON:0006376 ! premacula segment of distal straight tubule [Term] id: CL:1001109 name: kidney loop of henle cortical thick ascending limb epithelial cell namespace: cell xref: KUPO:0001052 is_a: CL:1001106 ! kidney loop of henle thick ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0006854 ! distal straight tubule postmacula segment relationship: part_of UBERON:0006854 ! distal straight tubule postmacula segment [Term] id: CL:1001111 name: kidney loop of henle thin descending limb epithelial cell namespace: cell xref: KUPO:0001054 is_a: CL:1000453 ! epithelial cell of intermediate tubule is_a: CL:1000616 ! kidney outer medulla cell is_a: CL:1001021 {is_inferred="true"} ! kidney loop of henle descending limb epithelial cell intersection_of: CL:1001021 ! kidney loop of henle descending limb epithelial cell intersection_of: part_of UBERON:0005096 ! descending thin limb relationship: part_of UBERON:0005096 ! descending thin limb [Term] id: CL:1001123 name: kidney outer medulla peritubular capillary cell namespace: cell xref: KUPO:0001066 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001033 {is_inferred="true"} ! peritubular capillary endothelial cell intersection_of: CL:1001033 ! peritubular capillary endothelial cell intersection_of: part_of UBERON:0006341 ! outer renal medulla peritubular capillary relationship: part_of UBERON:0006341 ! outer renal medulla peritubular capillary [Term] id: CL:1001124 name: kidney cortex peritubular capillary cell namespace: cell xref: KUPO:0001067 is_a: CL:1001033 {is_inferred="true"} ! peritubular capillary endothelial cell intersection_of: CL:1001033 ! peritubular capillary endothelial cell intersection_of: part_of UBERON:0006851 ! renal cortex peritubular capillary relationship: part_of UBERON:0006851 ! renal cortex peritubular capillary [Term] id: CL:1001126 name: inner renal medulla vasa recta cell namespace: cell xref: KUPO:0001069 is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0004776 ! inner renal medulla vasa recta relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta [Term] id: CL:1001127 name: outer renal medulla vasa recta cell namespace: cell xref: KUPO:0001070 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0004775 ! outer renal medulla vasa recta relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta [Term] id: CL:1001131 name: vasa recta ascending limb cell namespace: cell xref: KUPO:0001074 is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0009091 ! vasa recta ascending limb relationship: part_of UBERON:0009091 ! vasa recta ascending limb [Term] id: CL:1001135 name: arcuate artery cell namespace: cell xref: KUPO:0001078 is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell intersection_of: CL:1001045 ! kidney cortex artery cell intersection_of: part_of UBERON:0001552 ! arcuate artery relationship: part_of UBERON:0001552 ! arcuate artery [Term] id: CL:1001138 name: interlobular artery cell namespace: cell xref: KUPO:0001081 is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell intersection_of: CL:1001045 ! kidney cortex artery cell intersection_of: part_of UBERON:0004723 ! interlobular artery relationship: part_of UBERON:0004723 ! interlobular artery [Term] id: CL:1001142 name: arcuate vein cell namespace: cell xref: KUPO:0001085 is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell intersection_of: CL:1001052 ! kidney cortex vein cell intersection_of: part_of UBERON:0004719 ! arcuate vein relationship: part_of UBERON:0004719 ! arcuate vein [Term] id: CL:1001145 name: interlobular vein cell namespace: cell xref: KUPO:0001088 is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell intersection_of: CL:1001052 ! kidney cortex vein cell intersection_of: part_of UBERON:0005168 ! interlobular vein relationship: part_of UBERON:0005168 ! interlobular vein [Term] id: CL:1001209 name: inner medulla vasa recta ascending limb cell namespace: cell xref: KUPO:0001075 is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell intersection_of: CL:1001131 ! vasa recta ascending limb cell intersection_of: part_of UBERON:0009092 ! inner medulla vasa recta ascending limb relationship: part_of UBERON:0009092 ! inner medulla vasa recta ascending limb [Term] id: CL:1001210 name: outer medulla vasa recta ascending limb cell namespace: cell xref: KUPO:0001076 is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell intersection_of: CL:1001131 ! vasa recta ascending limb cell intersection_of: part_of UBERON:0009093 ! outer medulla vasa recta ascending limb relationship: part_of UBERON:0009093 ! outer medulla vasa recta ascending limb [Term] id: CL:1001213 name: arcuate artery endothelial cell namespace: cell xref: KUPO:0001079 is_a: CL:1000413 {is_inferred="true"} ! endothelial cell of artery is_a: CL:1001135 ! arcuate artery cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001552 ! arcuate artery relationship: part_of UBERON:0001552 ! arcuate artery [Term] id: CL:1001214 name: arcuate artery smooth muscle cell namespace: cell xref: KUPO:0001080 is_a: CL:1001064 ! kidney artery smooth muscle cell is_a: CL:1001135 ! arcuate artery cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001552 ! arcuate artery relationship: part_of UBERON:0001552 ! arcuate artery [Term] id: CL:1001216 name: interlobulary artery endothelial cell namespace: cell xref: KUPO:0001082 is_a: CL:1000413 ! endothelial cell of artery is_a: CL:1001138 ! interlobular artery cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004723 ! interlobular artery relationship: part_of UBERON:0004723 ! interlobular artery [Term] id: CL:1001217 name: interlobulary artery smooth muscle cell namespace: cell xref: KUPO:0001083 is_a: CL:1001064 ! kidney artery smooth muscle cell is_a: CL:1001138 ! interlobular artery cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004723 ! interlobular artery relationship: part_of UBERON:0004723 ! interlobular artery [Term] id: CL:1001220 name: arcuate vein endothelial cell namespace: cell xref: KUPO:0001086 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1001142 ! arcuate vein cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004719 ! arcuate vein relationship: part_of UBERON:0004719 ! arcuate vein [Term] id: CL:1001221 name: arcuate vein smooth muscle cell namespace: cell xref: KUPO:0001087 is_a: CL:1001068 ! kidney venous system smooth muscle cell is_a: CL:1001142 ! arcuate vein cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004719 ! arcuate vein relationship: part_of UBERON:0004719 ! arcuate vein [Term] id: CL:1001223 name: interlobulary vein endothelial cell namespace: cell xref: KUPO:0001089 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1001145 ! interlobular vein cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0005168 ! interlobular vein relationship: part_of UBERON:0005168 ! interlobular vein [Term] id: CL:1001224 name: interlobulary vein smooth muscle cell namespace: cell xref: KUPO:0001090 is_a: CL:1001068 ! kidney venous system smooth muscle cell is_a: CL:1001145 ! interlobular vein cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0005168 ! interlobular vein relationship: part_of UBERON:0005168 ! interlobular vein [Term] id: CL:1001225 name: kidney collecting duct cell namespace: cell xref: KUPO:0001012 xref: Wikipedia:Kidney_collecting_duct_cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001285 name: vasa recta descending limb cell namespace: cell xref: KUPO:0001071 is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0009202 ! vasa recta descending limb relationship: part_of UBERON:0009202 ! vasa recta descending limb [Term] id: CL:1001286 name: inner medulla vasa recta descending limb cell namespace: cell xref: KUPO:0001072 is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell intersection_of: CL:1001285 ! vasa recta descending limb cell intersection_of: part_of UBERON:0009089 ! inner medulla vasa recta descending limb relationship: part_of UBERON:0009089 ! inner medulla vasa recta descending limb [Term] id: CL:1001287 name: outer medulla vasa recta descending limb cell namespace: cell xref: KUPO:0001073 is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell intersection_of: CL:1001285 ! vasa recta descending limb cell intersection_of: part_of UBERON:0009090 ! outer medulla vasa recta descending limb relationship: part_of UBERON:0009090 ! outer medulla vasa recta descending limb [Term] id: CL:1001318 name: renal interstitial pericyte namespace: cell xref: KUPO:0001104 is_a: CL:0000669 {is_inferred="true"} ! pericyte cell is_a: CL:1000497 ! kidney cell intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1001319 name: bladder cell namespace: cell xref: KUPO:0001120 is_a: CL:1000600 ! lower urinary tract cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder [Term] id: CL:1001320 name: urethra cell namespace: cell xref: KUPO:0001123 is_a: CL:1000600 ! lower urinary tract cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: CL:1001428 name: bladder urothelial cell namespace: cell xref: KUPO:0001121 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1001319 {is_inferred="true"} ! bladder cell intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0004645 ! urinary bladder urothelium relationship: part_of UBERON:0004645 ! urinary bladder urothelium [Term] id: CL:1001430 name: urethra urothelial cell namespace: cell xref: KUPO:0001124 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1000296 ! epithelial cell of urethra intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0004787 ! urethra urothelium relationship: part_of UBERON:0004787 ! urethra urothelium [Term] id: CL:1001431 name: kidney collecting duct principal cell namespace: cell xref: KUPO:0001128 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001432 name: kidney collecting duct intercalated cell namespace: cell xref: http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells xref: KUPO:0001129 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001433 name: epithelial cell of exocrine pancreas namespace: cell def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000083 ! epithelial cell of pancreas intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: CL:1001434 name: olfactory bulb interneuron namespace: cl def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310] is_a: CL:0000101 ! sensory neuron is_a: CL:0000402 ! CNS interneuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0002264 ! olfactory bulb [Term] id: CL:1001435 name: periglomerular cell namespace: cl def: "the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [MP:0009943] synonym: "glomerular layer cell" EXACT [NIF_Cell:nifext_122] synonym: "olfactory bulb (accessory) glomerular layer cell" EXACT [NIF_Cell:nifext_122] synonym: "olfactory bulb glomerular layer cell" EXACT [NIF_Cell:nifext_122] synonym: "olfactory bulb glomerularal cell" EXACT [MP:0009943] synonym: "periglomerular cell" EXACT [NIF_Cell:nifext_122] xref: BTO:0003796 xref: NIF_Cell:nifext_122 is_a: CL:1001434 ! olfactory bulb interneuron relationship: part_of UBERON:0005377 ! olfactory bulb glomerular layer [Term] id: CL:1001436 name: hair-tylotrich neuron namespace: cl def: "the subcutaneous mechanoreceptors that innervate tylotrich hair follicles" [MP:0000977] is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001437 name: hair-down neuron namespace: cl def: "the subcutaneous mechanoreceptors that innervate vellus hairs" [MP:0000979] is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001451 name: sensory neuron of dorsal root ganglion namespace: cl def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297] synonym: "proprioceptive neuron" EXACT [MP:0004297] is_a: CL:0009000 ! sensory neuron of spinal nerve intersection_of: CL:0000101 ! sensory neuron intersection_of: part_of UBERON:0000044 ! dorsal root ganglion relationship: part_of UBERON:0000044 ! dorsal root ganglion [Term] id: CL:1001474 name: medium spiny neuron namespace: cl def: "the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [MP:0008462] synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778] xref: BTO:0004778 is_a: CL:0000540 ! neuron relationship: part_of UBERON:0000369 ! corpus striatum [Term] id: CL:1001502 name: mitral cell namespace: cl def: "the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [MP:0009954] is_a: CL:1001434 ! olfactory bulb interneuron relationship: part_of UBERON:0004186 ! olfactory bulb mitral cell layer [Term] id: CL:1001503 name: olfactory bulb tufted cell namespace: cl def: "the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala" [MP:0009955] is_a: CL:0000540 ! neuron relationship: part_of UBERON:0005376 ! olfactory bulb external plexiform layer [Term] id: CL:1001505 name: parvocellular neurosecretory cell namespace: cl def: "the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system" [MP:0010125] is_a: CL:0011112 ! magnocellular neurosecretory cell relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus relationship: RO:0002215 GO:0030103 ! capable_of vasopressin secretion [Term] id: CL:1001509 name: glycinergic neuron namespace: cl def: "the neurons that utilize glycine as a neurotransmitter" [MP:0010385] is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061537 ! capable_of glycine secretion, neurotransmission relationship: RO:0002215 GO:0061537 ! capable_of glycine secretion, neurotransmission [Term] id: CL:1001516 name: intestinal enteroendocrine cell namespace: cl def: "the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MP:0010802] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001242 ! intestinal mucosa relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: CL:1001517 name: stomach enteroendocrine cell namespace: cl def: "the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MP:0010803] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach [Term] id: CL:1001561 name: vomeronasal sensory neuron namespace: cl def: "chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MP:0011679] is_a: CL:0000101 ! sensory neuron relationship: part_of UBERON:0002255 ! vomeronasal organ [Term] id: CL:1001566 name: bronchioalveolar stem cells namespace: cl def: "a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury." [MP:0011691] is_a: CL:0000034 ! stem cell relationship: part_of UBERON:0000115 ! lung epithelium [Term] id: CL:1001567 name: lung endothelial cell namespace: cl synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000102 ! lung vasculature relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1001568 name: pulmonary artery endothelial cell namespace: cl synonym: "PAEC cell" RELATED [BTO:0001141] xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0005317 ! pulmonary artery endothelium [Term] id: CL:1001569 name: hippocampal interneuron namespace: cl def: "An interneuron of the hippocampus." [GOC:pr] xref: FMA:84777 is_a: CL:0000402 ! CNS interneuron is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:1001571 name: hippocampal pyramidal neuron namespace: cl def: "A pyramidal cell of the hippocampus." [GOC:pr, PMID:19342486] synonym: "hippocampus (CA) pyramidal cell" EXACT [NIF_Cell:sao131261273] synonym: "hippocampus (CA) pyramidal neuron" EXACT [NIF_Cell:sao131261273] xref: NIF_Cell:sao131261273 xref: SAO:sao131261273 is_a: CL:0000598 ! pyramidal cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000598 ! pyramidal cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0002313 ! hippocampus pyramidal layer [Term] id: CL:1001572 name: colon endothelial cell def: "Vascular endothelium found in colon blood vessels." [NPX:PDR] synonym: "colon endothelial cells" RELATED PLURAL [CALOHA:TS-2397] synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397] xref: CALOHA:TS-2397 is_a: CL:0000115 ! endothelial cell is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0013695 ! colon endothelium [Term] id: CL:1001573 name: nasopharyngeal epithelial cell def: "Cell of the nasopharyngeal epithelium." [NPX:PDR] synonym: "nasopharynx respiratory epithelial cells" RELATED [CALOHA:TS-2398] xref: CALOHA:TS-2398 is_a: CL:0002251 ! epithelial cell of alimentary canal is_a: CL:0002631 ! epithelial cell of upper respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001951 ! epithelium of nasopharynx [Term] id: CL:1001575 name: uterine cervix squamous cell def: "Squamous cell of uterine cervix epithelium." [NPX:PDR] synonym: "cervix squamous cell" RELATED [CALOHA:TS-1251] synonym: "cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] synonym: "cervix, uterine squamous epithelial cells" RELATED [CALOHA:TS-1251] synonym: "uterine cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] synonym: "uterine cervix squamous epithelial cells" RELATED [CALOHA:TS-1251] xref: CALOHA:TS-1251 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium [Term] id: CL:1001576 name: oral mucosa squamous cell def: "Squamous cell of oral epithelium." [NPX:PDR] synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252] synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252] xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: part_of UBERON:0002424 ! oral epithelium [Term] id: CL:1001577 name: tonsil squamous cell def: "Squamous cell of tonsil epithelium." [NPX:PDR] synonym: "tonsil squamous epithelial cell" RELATED [CALOHA:TS-1253] synonym: "tonsil squamous epithelial cells" RELATED [CALOHA:TS-1253] synonym: "tonsillar squamous cell" RELATED [CALOHA:TS-1253] synonym: "tonsillar squamous epithelial cell" RELATED [CALOHA:TS-1253] xref: CALOHA:TS-1253 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0013696 ! tonsil epithelium [Term] id: CL:1001578 name: vagina squamous cell def: "Squamous cell of vaginal epithelium." [NPX:PDR] synonym: "vagina squamous epithelial cell" RELATED [CALOHA:TS-1254] synonym: "vagina squamous epithelial cells" RELATED [CALOHA:TS-1254] synonym: "vaginal squamous cell" RELATED [CALOHA:TS-1254] synonym: "vaginal squamous epithelial cell" RELATED [CALOHA:TS-1254] xref: CALOHA:TS-1254 is_a: CL:0000076 ! squamous epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0001344 ! epithelium of vagina [Term] id: CL:1001579 name: cerebral cortex glial cell def: "Glial cell of cerebral cortex." [NPX:PDR] synonym: "brain cortex glial cell" RELATED [CALOHA:TS-1256] synonym: "cerebral cortex glial cells" RELATED [CALOHA:TS-1256] synonym: "cerebrum cortex glial cell" RELATED [CALOHA:TS-1256] xref: CALOHA:TS-1256 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:1001580 name: hippocampus glial cell def: "Glial cell of hippocampus." [NPX:PDR] synonym: "hippocampal glial cell" RELATED [CALOHA:TS-1257] synonym: "hippocampus glial cells" RELATED [CALOHA:TS-1257] synonym: "hippocampus neuroglial cell" RELATED [CALOHA:TS-1257] xref: CALOHA:TS-1257 is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:1001581 name: lateral ventricle glial cell def: "Glial cell of lateral ventricle." [NPX:PDR] synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258] xref: CALOHA:TS-1258 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: CL:1001582 name: lateral ventricle neuron def: "Neuron of lateral ventricle." [NPX:PDR] synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261] xref: CALOHA:TS-1261 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: CL:1001583 name: obsolete breast adipocyte def: "OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma." [HPA:Breast] synonym: "breast adipocytes" RELATED [CALOHA:TS-2377] is_obsolete: true replaced_by: CL:0002617 [Term] id: CL:1001585 name: appendix glandular cell def: "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "appendix glandular cells" RELATED [CALOHA:TS-1271] synonym: "caecal appendix glandular cell" RELATED [CALOHA:TS-1271] synonym: "cecal appendix glandular cell" RELATED [CALOHA:TS-1271] synonym: "vermiform appendix glandular cell" RELATED [CALOHA:TS-1271] xref: CALOHA:TS-1271 is_a: CL:1000405 ! epithelial cell of appendix is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0009697 ! epithelium of appendix [Term] id: CL:1001586 name: mammary gland glandular cell def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [NPX:PDR;HPA\:HPA] synonym: "breast glandular cell" RELATED [CALOHA:TS-1272] synonym: "breast glandular cells" RELATED [CALOHA:TS-1272] synonym: "mammary glandular cell" RELATED [CALOHA:TS-1272] xref: CALOHA:TS-1272 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0003244 ! epithelium of mammary gland [Term] id: CL:1001587 name: uterine cervix glandular cell def: "Glandular cell of uterine cervix epithelium." [NPX:PDR] synonym: "cervix glandular cell" RELATED [CALOHA:TS-1273] synonym: "cervix, uterine glandular cell" RELATED [CALOHA:TS-1273] synonym: "cervix, uterine glandular cells" RELATED [CALOHA:TS-1273] xref: CALOHA:TS-1273 is_a: CL:0002535 ! epithelial cell of cervix is_a: CL:1001591 ! oviduct glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium [Term] id: CL:1001588 name: colon glandular cell def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "colon glandular cells" RELATED [CALOHA:TS-1274] xref: CALOHA:TS-1274 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0001155 ! colon [Term] id: CL:1001589 name: duodenum glandular cell def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] synonym: "duodenum glandular cells" RELATED [CALOHA:TS-1275] xref: CALOHA:TS-1275 is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1001590 name: epididymis glandular cell def: "Glandular cell of epididymal epithelium." [NPX:PDR] synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276] synonym: "epididymis glandular cells" RELATED [CALOHA:TS-1276] xref: CALOHA:TS-1276 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0004544 ! epididymis epithelium [Term] id: CL:1001591 name: oviduct glandular cell def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [NPX:PDR;HPA\:HPA] synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277] synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277] synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277] xref: CALOHA:TS-1277 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0004804 ! oviduct epithelium [Term] id: CL:1001592 name: gall bladder glandular cell def: "Glandular cell of gall bladder epithelium." [NPX:PDR] synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cell" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278] xref: CALOHA:TS-1278 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1000415 ! epithelial cell of gall bladder intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002029 ! epithelium of gall bladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: CL:1001593 name: parathyroid glandular cell def: "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." [NPX:PDR;HPA\:HPA] synonym: "parathyroid gland glandular cell" RELATED [CALOHA:TS-1279] synonym: "parathyroid gland glandular cells" RELATED [CALOHA:TS-1279] xref: CALOHA:TS-1279 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0011197 ! parathyroid epithelium [Term] id: CL:1001595 name: rectum glandular cell def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281] synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281] xref: CALOHA:TS-1281 is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0003354 ! epithelium of rectum [Term] id: CL:1001596 name: salivary gland glandular cell def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [NPX:PDR;HPA\:HPA] synonym: "salivary gland glandular cells" RELATED [CALOHA:TS-1282] xref: CALOHA:TS-1282 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001044 ! salivary gland relationship: part_of UBERON:0001044 ! salivary gland relationship: part_of UBERON:0004809 ! salivary gland epithelium [Term] id: CL:1001597 name: seminal vesicle glandular cell def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR] synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283] xref: CALOHA:TS-1283 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0004805 ! seminal vesicle epithelium [Term] id: CL:1001598 name: small intestine glandular cell def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell;NPX\:PDR] synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestinal glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286] xref: CALOHA:TS-1286 xref: FMA:86928 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1001599 name: pancreas exocrine glandular cell def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [NPX:PDR;HPA\:HPA] synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242] synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242] xref: BTO:0000028 xref: CALOHA:TS-1242 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium [Term] id: CL:1001601 name: adrenal gland glandular cell def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." [NPX:PDR] synonym: "adrenal gland glandular cells" RELATED [CALOHA:TS-2177] synonym: "adrenal glandular cell" RELATED [CALOHA:TS-2177] synonym: "suprarenal gland glandular cell" RELATED [CALOHA:TS-2177] xref: CALOHA:TS-2177 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: CL:1001602 name: cerebral cortex endothelial cell def: "Endothelial cells forming the walls of the capillaries within the cerebral cortex." [NPX:PDR] synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372] synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372] xref: CALOHA:TS-2372 is_a: CL:0000115 ! endothelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0013694 ! brain endothelium [Term] id: CL:1001603 name: lung macrophage def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [NPX:PDR;HPA\:HPA] synonym: "lung macrophages" RELATED [CALOHA:TS-0576] xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1001606 name: foreskin keratinocyte def: "Keratinocyte from foreskin." [NPX:PDR] xref: CALOHA:TS-0385 is_a: CL:0000312 ! keratinocyte intersection_of: CL:0000312 ! keratinocyte intersection_of: part_of UBERON:0001332 ! prepuce of penis relationship: part_of UBERON:0001332 ! prepuce of penis [Term] id: CL:1001607 name: articular chondrocyte def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR] xref: CALOHA:TS-0056 is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: part_of UBERON:0010996 ! articular cartilage of joint relationship: part_of UBERON:0010996 ! articular cartilage of joint [Term] id: CL:1001608 name: foreskin fibroblast def: "Fibroblast from foreskin." [NPX:PDR] xref: CALOHA:TS-0384 is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0001332 ! prepuce of penis relationship: part_of UBERON:0001332 ! prepuce of penis [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [NPX:PDR] xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001630 ! muscle organ relationship: part_of UBERON:0001630 ! muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109] synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109] xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0012429 ! hemopoietic tissue [Term] id: CL:1001611 name: cerebellar neuron def: "Neuron of the cerebellum." [NPX:PDR] synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359] xref: CALOHA:TS-2359 xref: FMA:84665 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:2000000 name: epidermal melanocyte namespace: cell def: "Any melanocyte that is part of a epidermis." [GOC:TermGenie] comment: These cells are found primarily, but not exclusively, in primates including humans is_a: CL:0000362 ! epidermal cell is_a: CL:0002484 ! epithelial melanocyte is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis created_by: TermGenie creation_date: 2014-02-03T23:03:09Z [Term] id: CL:2000001 name: peripheral blood mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood created_by: TermGenie creation_date: 2014-02-11T17:29:04Z [Term] id: CL:2000002 name: decidua cell namespace: cell def: "Any native cell that is part of a decidua." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0002450 ! decidua relationship: part_of UBERON:0002450 ! decidua created_by: TermGenie creation_date: 2014-02-20T23:06:41Z [Term] id: CLO:0000001 name: cell line cell is_a: CL:0000010 ! cultured cell [Term] id: CLO:0000018 name: mortal cell line cell is_a: CLO:0000001 ! cell line cell [Term] id: CLO:0000019 name: immortal cell line cell is_a: CLO:0000001 ! cell line cell [Term] id: CP:0000000 name: neutrophillic cytoplasm namespace: cell def: "Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm created_by: tmeehan creation_date: 2010-05-25T01:36:34Z [Term] id: CP:0000025 name: lobed nucleus namespace: cell def: "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0001979 ! lobed relationship: bearer_of PATO:0001979 ! lobed created_by: tmeehan creation_date: 2009-12-22T03:54:43Z [Term] id: CP:0000027 name: acidophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions." [GOC:tfm] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 ! cytoplasm created_by: tmeehan creation_date: 2009-12-22T04:23:25Z [Term] id: CP:0000028 name: basophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: bearer_of PATO:0002094 ! basophilic relationship: bearer_of PATO:0002094 ! basophilic created_by: tmeehan creation_date: 2009-12-22T04:24:54Z [Term] id: CP:0000035 name: polychromatophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm created_by: tmeehan creation_date: 2009-12-28T04:25:23Z [Term] id: CP:0000037 name: increased nucleus size namespace: cell def: "A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0000586 ! increased size relationship: bearer_of PATO:0000586 ! increased size created_by: tmeehan creation_date: 2009-12-23T10:53:24Z [Term] id: CP:0000039 name: banded nucleus namespace: cell def: "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." [GOC:tfm] is_a: GO:0005634 ! nucleus created_by: tmeehan creation_date: 2009-12-23T02:18:43Z [Term] id: CP:0000040 name: reniform nucleus namespace: cell def: "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0001871 ! reniform relationship: bearer_of PATO:0001871 ! reniform created_by: tmeehan creation_date: 2009-12-23T02:31:25Z [Term] id: CP:0000043 name: cartwheel heterochromatin namespace: cell def: "Heterochromatin that is arranged in a carthwheel pattern." [GOC:tfm] is_a: GO:0000792 ! heterochromatin created_by: tmeehan creation_date: 2009-12-28T04:28:35Z [Term] id: GO:0000003 name: reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000018 name: regulation of DNA recombination is_a: GO:0051052 ! regulation of DNA metabolic process [Term] id: GO:0000070 name: mitotic sister chromatid segregation is_a: GO:0000819 ! sister chromatid segregation intersection_of: GO:0007059 ! chromosome segregation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000226 name: microtubule cytoskeleton organization is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0000228 name: nuclear chromosome is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000229 name: cytoplasmic chromosome is_a: GO:0005694 ! chromosome is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000278 name: mitotic cell cycle is_a: GO:0007049 ! cell cycle [Term] id: GO:0000280 name: nuclear division is_a: GO:0048285 ! organelle fission relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000313 name: organellar ribosome is_a: GO:0005840 ! ribosome is_a: GO:0044422 ! organelle part intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0043226 ! organelle [Term] id: GO:0000323 name: lytic vacuole is_a: GO:0005773 ! vacuole [Term] id: GO:0000785 name: chromatin is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000789 name: cytoplasmic chromatin is_a: GO:0000785 ! chromatin is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000790 name: nuclear chromatin is_a: GO:0000785 ! chromatin is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000791 name: euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000819 name: sister chromatid segregation is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0000902 name: cell morphogenesis is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0001501 name: skeletal system development is_a: GO:0048731 ! system development [Term] id: GO:0001503 name: ossification is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0001505 name: regulation of neurotransmitter levels is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0001553 name: luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001578 name: microtubule bundle formation is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001649 name: osteoblast differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001503 ! ossification [Term] id: GO:0001667 name: ameboidal cell migration is_a: GO:0016477 ! cell migration [Term] id: GO:0001675 name: acrosome assembly is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0044702 ! single organism reproductive process is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001773 name: myeloid dendritic cell activation is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001775 name: cell activation is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0001816 name: cytokine production is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0001817 name: regulation of cytokine production is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0001818 name: negative regulation of cytokine production is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process [Term] id: GO:0001820 name: serotonin secretion is_a: GO:0006837 ! serotonin transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001894 name: tissue homeostasis is_a: GO:0060249 ! anatomical structure homeostasis relationship: part_of GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001906 name: cell killing is_a: GO:0008150 ! biological_process [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity is_a: GO:0001906 ! cell killing is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0001913 name: T cell mediated cytotoxicity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0044699 ! single-organism process [Term] id: GO:0001974 name: blood vessel remodeling is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0002200 name: somatic diversification of immune receptors is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002215 name: defense response to nematode is_a: GO:0009624 ! response to nematode is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002227 name: innate immune response in mucosa is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002246 name: wound healing involved in inflammatory response is_a: GO:0042060 ! wound healing intersection_of: GO:0042060 ! wound healing intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002249 name: lymphocyte anergy is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process is_a: GO:0002376 ! immune system process [Term] id: GO:0002262 name: myeloid cell homeostasis is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0002263 name: cell activation involved in immune response is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002274 name: myeloid leukocyte activation is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response intersection_of: GO:0001773 ! myeloid dendritic cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002286 name: T cell activation involved in immune response is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation intersection_of: GO:0042110 ! T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0046631 ! alpha-beta T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002288 name: NK T cell activation involved in immune response is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation intersection_of: GO:0051132 ! NK T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation intersection_of: GO:0046629 ! gamma-delta T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030217 ! T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation intersection_of: GO:0042492 ! gamma-delta T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002312 name: B cell activation involved in immune response is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation intersection_of: GO:0042113 ! B cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation intersection_of: GO:0002335 ! mature B cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002314 name: germinal center B cell differentiation is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002335 name: mature B cell differentiation is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002339 name: B cell selection is_a: GO:0002376 ! immune system process relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002343 name: peripheral B cell selection is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation is_a: GO:0002343 ! peripheral B cell selection relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002349 name: histamine production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002351 name: serotonin production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002366 name: leukocyte activation involved in immune response is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002367 name: cytokine production involved in immune response is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002369 name: T cell cytokine production is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002376 name: immune system process is_a: GO:0008150 ! biological_process [Term] id: GO:0002377 name: immunoglobulin production is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin mediated immune response is_a: GO:0002377 ! immunoglobulin production intersection_of: GO:0002377 ! immunoglobulin production intersection_of: part_of GO:0016064 ! immunoglobulin mediated immune response relationship: part_of GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002385 name: mucosal immune response is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002432 name: granuloma formation is_a: GO:0002252 ! immune effector process relationship: part_of GO:0002544 ! chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response is_a: GO:0002376 ! immune system process [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0001821 ! histamine secretion intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0002349 ! histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response is_a: GO:0001820 ! serotonin secretion intersection_of: GO:0001820 ! serotonin secretion intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity is_a: GO:0002252 ! immune effector process [Term] id: GO:0002449 name: lymphocyte mediated immunity is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002456 name: T cell mediated immunity is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002507 name: tolerance induction is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002514 name: B cell tolerance induction is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002520 name: immune system development is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002521 name: leukocyte differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002522 name: leukocyte migration involved in immune response is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response is_a: GO:0044707 ! single-multicellular organism process relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response intersection_of: GO:0001816 ! cytokine production intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonic acid metabolite production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002548 name: monocyte chemotaxis is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002573 name: myeloid leukocyte differentiation is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002634 name: regulation of germinal center formation is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002637 name: regulation of immunoglobulin production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response [Term] id: GO:0002643 name: regulation of tolerance induction is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:0002645 name: positive regulation of tolerance induction is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002658 name: regulation of peripheral tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction [Term] id: GO:0002679 name: respiratory burst involved in defense response is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0006952 ! defense response relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002682 name: regulation of immune system process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0002683 name: negative regulation of immune system process is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process [Term] id: GO:0002684 name: positive regulation of immune system process is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0002685 name: regulation of leukocyte migration is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis [Term] id: GO:0002694 name: regulation of leukocyte activation is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation [Term] id: GO:0002697 name: regulation of immune effector process is_a: GO:0002682 ! regulation of immune system process [Term] id: GO:0002699 name: positive regulation of immune effector process is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response is_a: GO:0002697 ! regulation of immune effector process [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity is_a: GO:0002697 ! regulation of immune effector process [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity is_a: GO:0002703 ! regulation of leukocyte mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002775 name: antimicrobial peptide production is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002776 name: antimicrobial peptide secretion is_a: GO:0002790 ! peptide secretion relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002790 name: peptide secretion is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002819 name: regulation of adaptive immune response is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002819 ! regulation of adaptive immune response [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002830 name: positive regulation of type 2 immune response is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response is_a: GO:0002712 ! regulation of B cell mediated immunity [Term] id: GO:0002902 name: regulation of B cell apoptotic process is_a: GO:0070228 ! regulation of lymphocyte apoptotic process [Term] id: GO:0002905 name: regulation of mature B cell apoptotic process is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0032844 ! regulation of homeostatic process [Term] id: GO:0003006 name: developmental process involved in reproduction is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0000003 ! reproduction [Term] id: GO:0003008 name: system process is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0003013 name: circulatory system process is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003674 name: molecular_function disjoint_from: GO:0005575 ! cellular_component disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0003676 name: nucleic acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0003677 name: DNA binding is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0004871 name: signal transducer activity is_a: GO:0060089 ! molecular transducer activity relationship: part_of GO:0007165 ! signal transduction [Term] id: GO:0004872 name: receptor activity is_a: GO:0003674 ! molecular_function [Term] id: GO:0004888 name: transmembrane signaling receptor activity is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0005044 name: scavenger receptor activity is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0005102 name: receptor binding is_a: GO:0005515 ! protein binding [Term] id: GO:0005215 name: transporter activity is_a: GO:0003674 ! molecular_function relationship: part_of GO:0006810 ! transport [Term] id: GO:0005488 name: binding is_a: GO:0003674 ! molecular_function [Term] id: GO:0005515 name: protein binding is_a: GO:0005488 ! binding [Term] id: GO:0005575 name: cellular_component disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0005576 name: extracellular region is_a: GO:0005575 ! cellular_component [Term] id: GO:0005615 name: extracellular space is_a: GO:0044421 ! extracellular region part [Term] id: GO:0005622 name: intracellular is_a: GO:0044464 ! cell part [Term] id: GO:0005623 name: cell is_a: GO:0005575 ! cellular_component [Term] id: GO:0005634 name: nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005694 name: chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005719 name: nuclear euchromatin is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000791 ! euchromatin intersection_of: GO:0000791 ! euchromatin intersection_of: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005720 name: nuclear heterochromatin is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005730 name: nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005737 name: cytoplasm is_a: GO:0044424 ! intracellular part [Term] id: GO:0005764 name: lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005766 name: primary lysosome is_a: GO:0005764 ! lysosome [Term] id: GO:0005773 name: vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005775 name: vacuolar lumen is_a: GO:0044437 ! vacuolar part is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005773 ! vacuole [Term] id: GO:0005794 name: Golgi apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005840 name: ribosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005886 name: plasma membrane is_a: GO:0016020 ! membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005887 name: integral component of plasma membrane is_a: GO:0016021 ! integral component of membrane is_a: GO:0044459 ! plasma membrane part intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0031226 ! intrinsic component of plasma membrane [Term] id: GO:0005902 name: microvillus is_a: GO:0042995 ! cell projection [Term] id: GO:0005911 name: cell-cell junction is_a: GO:0030054 ! cell junction [Term] id: GO:0005929 name: cilium is_a: GO:0042995 ! cell projection is_a: GO:0043227 ! membrane-bounded organelle relationship: has_part GO:0030990 ! intraciliary transport particle [Term] id: GO:0006022 name: aminoglycan metabolic process is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006023 name: aminoglycan biosynthetic process is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006082 name: organic acid metabolic process is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006259 name: DNA metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006310 name: DNA recombination is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006323 name: DNA packaging is_a: GO:0016043 ! cellular component organization is_a: GO:0071103 ! DNA conformation change relationship: has_part GO:0008301 ! DNA binding, bending [Term] id: GO:0006725 name: cellular aromatic compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006801 name: superoxide metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0006807 name: nitrogen compound metabolic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0006810 name: transport is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: ion transport is_a: GO:0044765 ! single-organism transport [Term] id: GO:0006812 name: cation transport is_a: GO:0006811 ! ion transport [Term] id: GO:0006820 name: anion transport is_a: GO:0006811 ! ion transport [Term] id: GO:0006835 name: dicarboxylic acid transport is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006836 name: neurotransmitter transport is_a: GO:0044765 ! single-organism transport [Term] id: GO:0006837 name: serotonin transport is_a: GO:0006812 ! cation transport is_a: GO:0015844 ! monoamine transport [Term] id: GO:0006865 name: amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0006869 name: lipid transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0006897 name: endocytosis is_a: GO:0016192 ! vesicle-mediated transport relationship: has_part GO:0010324 ! membrane invagination [Term] id: GO:0006898 name: receptor-mediated endocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006909 name: phagocytosis is_a: GO:0006897 ! endocytosis is_a: GO:0044765 ! single-organism transport [Term] id: GO:0006911 name: phagocytosis, engulfment is_a: GO:0010324 ! membrane invagination intersection_of: GO:0010324 ! membrane invagination intersection_of: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006915 name: apoptotic process is_a: GO:0012501 ! programmed cell death [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: part_of GO:0097194 ! execution phase of apoptosis relationship: part_of GO:0097194 ! execution phase of apoptosis [Term] id: GO:0006928 name: cellular component movement is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0006935 name: chemotaxis is_a: GO:0042221 ! response to chemical is_a: GO:0042330 ! taxis [Term] id: GO:0006937 name: regulation of muscle contraction is_a: GO:0090257 ! regulation of muscle system process [Term] id: GO:0006940 name: regulation of smooth muscle contraction is_a: GO:0006937 ! regulation of muscle contraction [Term] id: GO:0006950 name: response to stress is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response is_a: GO:0006952 ! defense response is_a: GO:0009611 ! response to wounding [Term] id: GO:0006955 name: immune response is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006959 name: humoral immune response is_a: GO:0006955 ! immune response [Term] id: GO:0006996 name: organelle organization is_a: GO:0009987 ! cellular process is_a: GO:0016043 ! cellular component organization [Term] id: GO:0006997 name: nucleus organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0007010 name: cytoskeleton organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0007017 name: microtubule-based process is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007049 name: cell cycle is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007059 name: chromosome segregation is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007067 name: mitosis is_a: GO:0000280 ! nuclear division is_a: GO:0022402 ! cell cycle process is_a: GO:1902589 ! single-organism organelle organization relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007076 name: mitotic chromosome condensation is_a: GO:0022402 ! cell cycle process is_a: GO:0030261 ! chromosome condensation intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007113 name: endomitotic cell cycle is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007126 name: meiosis is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007135 name: meiosis II is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0007140 name: male meiosis is_a: GO:0007126 ! meiosis [Term] id: GO:0007142 name: male meiosis II is_a: GO:0007135 ! meiosis II relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007143 name: female meiosis is_a: GO:0007126 ! meiosis [Term] id: GO:0007147 name: female meiosis II is_a: GO:0007135 ! meiosis II relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007154 name: cell communication is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007165 name: signal transduction is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051716 ! cellular response to stimulus relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0044700 ! single organism signaling [Term] id: GO:0007267 name: cell-cell signaling is_a: GO:0007154 ! cell communication is_a: GO:0044700 ! single organism signaling [Term] id: GO:0007268 name: synaptic transmission is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0007269 name: neurotransmitter secretion is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0023061 ! signal release [Term] id: GO:0007275 name: multicellular organismal development is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0007276 name: gamete generation is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007281 name: germ cell development is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048468 ! cell development relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007283 name: spermatogenesis is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007286 name: spermatid development is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation [Term] id: GO:0007288 name: sperm axoneme assembly is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0035082 ! axoneme assembly is_a: GO:0044702 ! single organism reproductive process relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007289 name: spermatid nucleus differentiation is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:1902589 ! single-organism organelle organization relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007292 name: female gamete generation is_a: GO:0007276 ! gamete generation [Term] id: GO:0007338 name: single fertilization is_a: GO:0009566 ! fertilization [Term] id: GO:0007399 name: nervous system development is_a: GO:0048731 ! system development [Term] id: GO:0007507 name: heart development is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048513 ! organ development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0007548 name: sex differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007585 name: respiratory gaseous exchange is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0007589 name: body fluid secretion is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007596 name: blood coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0007599 name: hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception is_a: GO:0050877 ! neurological system process [Term] id: GO:0007601 name: visual perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007605 name: sensory perception of sound is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus is_a: GO:0007600 ! sensory perception [Term] id: GO:0007608 name: sensory perception of smell is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0008015 name: blood circulation is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008104 name: protein localization is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008150 name: biological_process [Term] id: GO:0008152 name: metabolic process is_a: GO:0008150 ! biological_process [Term] id: GO:0008219 name: cell death is_a: GO:0016265 ! death is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0008283 name: cell proliferation is_a: GO:0044699 ! single-organism process [Term] id: GO:0008284 name: positive regulation of cell proliferation is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048522 ! positive regulation of cellular process [Term] id: GO:0008285 name: negative regulation of cell proliferation is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048523 ! negative regulation of cellular process [Term] id: GO:0008289 name: lipid binding is_a: GO:0005488 ! binding [Term] id: GO:0008301 name: DNA binding, bending is_a: GO:0003677 ! DNA binding [Term] id: GO:0008406 name: gonad development is_a: GO:0044702 ! single organism reproductive process is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048513 ! organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0045137 ! development of primary sexual characteristics [Term] id: GO:0008509 name: anion transmembrane transporter activity is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0006820 ! anion transport [Term] id: GO:0008514 name: organic anion transmembrane transporter activity is_a: GO:0008509 ! anion transmembrane transporter activity relationship: part_of GO:0015711 ! organic anion transport [Term] id: GO:0008585 name: female gonad development is_a: GO:0008406 ! gonad development relationship: part_of GO:0046545 ! development of primary female sexual characteristics [Term] id: GO:0009058 name: biosynthetic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0009059 name: macromolecule biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009266 name: response to temperature stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009306 name: protein secretion is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0009314 name: response to radiation is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009411 name: response to UV is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009416 name: response to light stimulus is_a: GO:0009314 ! response to radiation [Term] id: GO:0009566 name: fertilization is_a: GO:0044702 ! single organism reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0009581 name: detection of external stimulus is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009589 name: detection of UV is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009593 name: detection of chemical stimulus is_a: GO:0042221 ! response to chemical is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009605 name: response to external stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009611 name: response to wounding is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009617 name: response to bacterium is_a: GO:0051707 ! response to other organism [Term] id: GO:0009624 name: response to nematode is_a: GO:0051707 ! response to other organism [Term] id: GO:0009628 name: response to abiotic stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009629 name: response to gravity is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009887 name: organ morphogenesis is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0048513 ! organ development [Term] id: GO:0009888 name: tissue development is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0009893 name: positive regulation of metabolic process is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0009914 name: hormone transport is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0044765 ! single-organism transport [Term] id: GO:0009987 name: cellular process is_a: GO:0008150 ! biological_process [Term] id: GO:0010032 name: meiotic chromosome condensation is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiosis intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0010324 name: membrane invagination is_a: GO:0061024 ! membrane organization [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process [Term] id: GO:0010623 name: developmental programmed cell death is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010817 name: regulation of hormone levels is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010876 name: lipid localization is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular component morphogenesis [Term] id: GO:0010941 name: regulation of cell death is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0012501 name: programmed cell death is_a: GO:0008219 ! cell death [Term] id: GO:0012505 name: endomembrane system is_a: GO:0044464 ! cell part relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane [Term] id: GO:0012506 name: vesicle membrane is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0031988 ! membrane-bounded vesicle [Term] id: GO:0014046 name: dopamine secretion is_a: GO:0015872 ! dopamine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0014047 name: glutamate secretion is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006865 ! amino acid transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion [Term] id: GO:0014704 name: intercalated disc is_a: GO:0044291 ! cell-cell contact zone [Term] id: GO:0014706 name: striated muscle tissue development is_a: GO:0060537 ! muscle tissue development [Term] id: GO:0015031 name: protein transport is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015075 name: ion transmembrane transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0034220 ! ion transmembrane transport [Term] id: GO:0015103 name: inorganic anion transmembrane transporter activity is_a: GO:0008509 ! anion transmembrane transporter activity relationship: part_of GO:0015698 ! inorganic anion transport [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015701 ! bicarbonate transport [Term] id: GO:0015669 name: gas transport is_a: GO:0044765 ! single-organism transport [Term] id: GO:0015671 name: oxygen transport is_a: GO:0015669 ! gas transport [Term] id: GO:0015695 name: organic cation transport is_a: GO:0006812 ! cation transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015698 name: inorganic anion transport is_a: GO:0006820 ! anion transport [Term] id: GO:0015701 name: bicarbonate transport is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015711 name: organic anion transport is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015718 name: monocarboxylic acid transport is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0015740 name: C4-dicarboxylate transport is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015800 name: acidic amino acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015807 name: L-amino acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015810 name: aspartate transport is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015800 ! acidic amino acid transport [Term] id: GO:0015812 name: gamma-aminobutyric acid transport is_a: GO:0006865 ! amino acid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015816 name: glycine transport is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport [Term] id: GO:0015833 name: peptide transport is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015844 name: monoamine transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015849 name: organic acid transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015850 name: organic hydroxy compound transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015870 name: acetylcholine transport is_a: GO:0006812 ! cation transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport [Term] id: GO:0015872 name: dopamine transport is_a: GO:0006812 ! cation transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015874 name: norepinephrine transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015893 name: drug transport is_a: GO:0044765 ! single-organism transport relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0016020 name: membrane is_a: GO:0005575 ! cellular_component [Term] id: GO:0016021 name: integral component of membrane is_a: GO:0044425 ! membrane part relationship: part_of GO:0031224 ! intrinsic component of membrane [Term] id: GO:0016023 name: cytoplasmic membrane-bounded vesicle is_a: GO:0031410 ! cytoplasmic vesicle is_a: GO:0031988 ! membrane-bounded vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle intersection_of: GO:0031988 ! membrane-bounded vesicle intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0016043 name: cellular component organization is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016048 name: detection of temperature stimulus is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0016050 name: vesicle organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0016064 name: immunoglobulin mediated immune response is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0016192 name: vesicle-mediated transport is_a: GO:0006810 ! transport [Term] id: GO:0016265 name: death is_a: GO:0044699 ! single-organism process [Term] id: GO:0016321 name: female meiosis chromosome segregation is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0007059 ! chromosome segregation intersection_of: part_of GO:0007143 ! female meiosis relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0016444 name: somatic cell DNA recombination is_a: GO:0006310 ! DNA recombination [Term] id: GO:0016445 name: somatic diversification of immunoglobulins is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0016446 name: somatic hypermutation of immunoglobulin genes is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016447 name: somatic recombination of immunoglobulin gene segments is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016477 name: cell migration is_a: GO:0048870 ! cell motility [Term] id: GO:0017145 name: stem cell division is_a: GO:0051301 ! cell division [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process [Term] id: GO:0019222 name: regulation of metabolic process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0019226 name: transmission of nerve impulse is_a: GO:0035637 ! multicellular organismal signaling is_a: GO:0050877 ! neurological system process relationship: part_of GO:0007154 ! cell communication [Term] id: GO:0019724 name: B cell mediated immunity is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0019730 name: antimicrobial humoral response is_a: GO:0006959 ! humoral immune response is_a: GO:0051707 ! response to other organism [Term] id: GO:0019814 name: immunoglobulin complex is_a: GO:0043234 ! protein complex [Term] id: GO:0019815 name: B cell receptor complex is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0019882 name: antigen processing and presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019884 name: antigen processing and presentation of exogenous antigen is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019953 name: sexual reproduction is_a: GO:0000003 ! reproduction is_a: GO:0044703 ! multi-organism reproductive process [Term] id: GO:0021700 name: developmental maturation is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0022008 name: neurogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022402 name: cell cycle process is_a: GO:0044763 ! single-organism cellular process intersection_of: GO:0044763 ! single-organism cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022411 name: cellular component disassembly is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism is_a: GO:0048610 ! cellular process involved in reproduction intersection_of: GO:0044763 ! single-organism cellular process intersection_of: part_of GO:0032504 ! multicellular organism reproduction relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0022414 name: reproductive process is_a: GO:0008150 ! biological_process relationship: part_of GO:0000003 ! reproduction [Term] id: GO:0022602 name: ovulation cycle process is_a: GO:0044699 ! single-organism process is_a: GO:0048511 ! rhythmic process relationship: part_of GO:0042698 ! ovulation cycle [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0022607 name: cellular component assembly is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0022857 name: transmembrane transporter activity is_a: GO:0005215 ! transporter activity relationship: part_of GO:0055085 ! transmembrane transport [Term] id: GO:0022891 name: substrate-specific transmembrane transporter activity is_a: GO:0022857 ! transmembrane transporter activity is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0022892 name: substrate-specific transporter activity is_a: GO:0005215 ! transporter activity [Term] id: GO:0023029 name: MHC class Ib protein binding is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0023052 name: signaling is_a: GO:0008150 ! biological_process [Term] id: GO:0023061 name: signal release is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0007267 ! cell-cell signaling [Term] id: GO:0030016 name: myofibril is_a: GO:0043292 ! contractile fiber [Term] id: GO:0030017 name: sarcomere is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0030030 name: cell projection organization is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0030031 name: cell projection assembly is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization [Term] id: GO:0030054 name: cell junction is_a: GO:0005575 ! cellular_component [Term] id: GO:0030072 name: peptide hormone secretion is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion [Term] id: GO:0030073 name: insulin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030097 name: hemopoiesis is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0030098 name: lymphocyte differentiation is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030099 name: myeloid cell differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0030103 name: vasopressin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030141 name: secretory granule is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030154 name: cell differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030182 name: neuron differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0030183 name: B cell differentiation is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation [Term] id: GO:0030198 name: extracellular matrix organization is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0030202 name: heparin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0030203 name: glycosaminoglycan metabolic process is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0030210 name: heparin biosynthetic process is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0030217 name: T cell differentiation is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation [Term] id: GO:0030218 name: erythrocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0030219 name: megakaryocyte differentiation is_a: GO:0002244 ! hematopoietic progenitor cell differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0030221 name: basophil differentiation is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030222 name: eosinophil differentiation is_a: GO:0030851 ! granulocyte differentiation is_a: GO:0048468 ! cell development [Term] id: GO:0030223 name: neutrophil differentiation is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030224 name: monocyte differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030225 name: macrophage differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030252 name: growth hormone secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030261 name: chromosome condensation is_a: GO:0006323 ! DNA packaging is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0030262 name: apoptotic nuclear changes is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis [Term] id: GO:0030263 name: apoptotic chromosome condensation is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0030316 name: osteoclast differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030317 name: sperm motility is_a: GO:0048870 ! cell motility [Term] id: GO:0030334 name: regulation of cell migration is_a: GO:2000145 ! regulation of cell motility [Term] id: GO:0030335 name: positive regulation of cell migration is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility [Term] id: GO:0030529 name: ribonucleoprotein complex is_a: GO:0032991 ! macromolecular complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030595 name: leukocyte chemotaxis is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0030659 name: cytoplasmic vesicle membrane is_a: GO:0012506 ! vesicle membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030667 name: secretory granule membrane is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0030141 ! secretory granule [Term] id: GO:0030851 name: granulocyte differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0030990 name: intraciliary transport particle is_a: GO:0043234 ! protein complex [Term] id: GO:0031090 name: organelle membrane is_a: GO:0016020 ! membrane is_a: GO:0044422 ! organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031224 name: intrinsic component of membrane is_a: GO:0044425 ! membrane part [Term] id: GO:0031226 name: intrinsic component of plasma membrane is_a: GO:0031224 ! intrinsic component of membrane is_a: GO:0044459 ! plasma membrane part intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0031253 name: cell projection membrane is_a: GO:0044459 ! plasma membrane part is_a: GO:0044463 ! cell projection part [Term] id: GO:0031268 name: pseudopodium organization is_a: GO:0030030 ! cell projection organization [Term] id: GO:0031294 name: lymphocyte costimulation is_a: GO:0002376 ! immune system process is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0031323 name: regulation of cellular metabolic process is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process [Term] id: GO:0031347 name: regulation of defense response is_a: GO:0080134 ! regulation of response to stress [Term] id: GO:0031348 name: negative regulation of defense response is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus [Term] id: GO:0031349 name: positive regulation of defense response is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus [Term] id: GO:0031410 name: cytoplasmic vesicle is_a: GO:0031982 ! vesicle is_a: GO:0043229 ! intracellular organelle is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031974 name: membrane-enclosed lumen is_a: GO:0005575 ! cellular_component [Term] id: GO:0031981 name: nuclear lumen is_a: GO:0044428 ! nuclear part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031982 name: vesicle is_a: GO:0043226 ! organelle [Term] id: GO:0031988 name: membrane-bounded vesicle is_a: GO:0031982 ! vesicle [Term] id: GO:0032101 name: regulation of response to external stimulus is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus [Term] id: GO:0032274 name: gonadotropin secretion is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032275 name: luteinizing hormone secretion is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0032394 name: MHC class Ib receptor activity is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0023029 ! MHC class Ib protein binding [Term] id: GO:0032501 name: multicellular organismal process is_a: GO:0008150 ! biological_process [Term] id: GO:0032502 name: developmental process is_a: GO:0008150 ! biological_process [Term] id: GO:0032504 name: multicellular organism reproduction is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032606 name: type I interferon production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032609 name: interferon-gamma production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032611 name: interleukin-1 beta production is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032612 name: interleukin-1 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032613 name: interleukin-10 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032616 name: interleukin-13 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032620 name: interleukin-17 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032623 name: interleukin-2 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032626 name: interleukin-22 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032633 name: interleukin-4 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032635 name: interleukin-6 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032637 name: interleukin-8 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032638 name: interleukin-9 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032640 name: tumor necrosis factor production is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032649 name: regulation of interferon-gamma production is_a: GO:0001817 ! regulation of cytokine production [Term] id: GO:0032689 name: negative regulation of interferon-gamma production is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production [Term] id: GO:0032814 name: regulation of natural killer cell activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0032838 name: cell projection cytoplasm is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044463 ! cell projection part [Term] id: GO:0032844 name: regulation of homeostatic process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0032879 name: regulation of localization is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0032880 name: regulation of protein localization is_a: GO:0032879 ! regulation of localization [Term] id: GO:0032940 name: secretion by cell is_a: GO:0044763 ! single-organism cellular process is_a: GO:0046903 ! secretion is_a: GO:0051649 ! establishment of localization in cell [Term] id: GO:0032941 name: secretion by tissue is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0046903 ! secretion [Term] id: GO:0032943 name: mononuclear cell proliferation is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation [Term] id: GO:0032989 name: cellular component morphogenesis is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0032990 name: cell part morphogenesis is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0032991 name: macromolecular complex is_a: GO:0005575 ! cellular_component [Term] id: GO:0032997 name: Fc receptor complex is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0033001 name: Fc-gamma receptor III complex is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033036 name: macromolecule localization is_a: GO:0051179 ! localization [Term] id: GO:0033151 name: V(D)J recombination is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus [Term] id: GO:0033152 name: immunoglobulin V(D)J recombination is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments is_a: GO:0033151 ! V(D)J recombination [Term] id: GO:0033326 name: cerebrospinal fluid secretion is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0033363 name: secretory granule organization is_a: GO:0016050 ! vesicle organization [Term] id: GO:0033365 name: protein localization to organelle is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0033366 name: protein localization to secretory granule is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0033371 name: T cell secretory granule organization is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0033374 name: protein localization to T cell secretory granule is_a: GO:0033366 ! protein localization to secretory granule relationship: part_of GO:0033371 ! T cell secretory granule organization [Term] id: GO:0033375 name: protease localization to T cell secretory granule is_a: GO:0033374 ! protein localization to T cell secretory granule [Term] id: GO:0033380 name: granzyme B localization to T cell secretory granule is_a: GO:0033375 ! protease localization to T cell secretory granule [Term] id: GO:0034101 name: erythrocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0034102 name: erythrocyte clearance is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0034220 name: ion transmembrane transport is_a: GO:0006811 ! ion transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034613 name: cellular protein localization is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0035010 name: encapsulation of foreign target is_a: GO:0002252 ! immune effector process [Term] id: GO:0035051 name: cardiocyte differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007507 ! heart development [Term] id: GO:0035082 name: axoneme assembly is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0042384 ! cilium assembly [Term] id: GO:0035369 name: pre-B cell receptor complex is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0035637 name: multicellular organismal signaling is_a: GO:0044700 ! single organism signaling is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0035929 name: steroid hormone secretion is_a: GO:0006869 ! lipid transport is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0035930 name: corticosteroid hormone secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0035931 name: mineralocorticoid secretion is_a: GO:0035930 ! corticosteroid hormone secretion [Term] id: GO:0035933 name: glucocorticoid secretion is_a: GO:0035930 ! corticosteroid hormone secretion [Term] id: GO:0035935 name: androgen secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0035936 name: testosterone secretion is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035935 ! androgen secretion [Term] id: GO:0035937 name: estrogen secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0035938 name: estradiol secretion is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035937 ! estrogen secretion [Term] id: GO:0036160 name: melanocyte-stimulating hormone secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0036161 name: calcitonin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0036321 name: ghrelin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0038023 name: signaling receptor activity is_a: GO:0004871 ! signal transducer activity is_a: GO:0004872 ! receptor activity intersection_of: GO:0004872 ! receptor activity intersection_of: part_of GO:0007165 ! signal transduction [Term] id: GO:0038024 name: cargo receptor activity is_a: GO:0004872 ! receptor activity intersection_of: GO:0004872 ! receptor activity intersection_of: part_of GO:0006898 ! receptor-mediated endocytosis relationship: part_of GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0040011 name: locomotion is_a: GO:0008150 ! biological_process [Term] id: GO:0040012 name: regulation of locomotion is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0040017 name: positive regulation of locomotion is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0042060 name: wound healing is_a: GO:0009611 ! response to wounding [Term] id: GO:0042101 name: T cell receptor complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: has_part PR:000001020 {comment="To be added to GO"} ! CD3 epsilon [Term] id: GO:0042105 name: alpha-beta T cell receptor complex is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042106 name: gamma-delta T cell receptor complex is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042110 name: T cell activation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042113 name: B cell activation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042127 name: regulation of cell proliferation is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0042129 name: regulation of T cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050863 ! regulation of T cell activation [Term] id: GO:0042130 name: negative regulation of T cell proliferation is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050868 ! negative regulation of T cell activation [Term] id: GO:0042221 name: response to chemical is_a: GO:0050896 ! response to stimulus [Term] id: GO:0042267 name: natural killer cell mediated cytotoxicity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0044699 ! single-organism process [Term] id: GO:0042287 name: MHC protein binding is_a: GO:0005102 ! receptor binding [Term] id: GO:0042330 name: taxis is_a: GO:0009605 ! response to external stimulus is_a: GO:0040011 ! locomotion [Term] id: GO:0042384 name: cilium assembly is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0060271 ! cilium morphogenesis [Term] id: GO:0042470 name: melanosome is_a: GO:0048770 ! pigment granule [Term] id: GO:0042475 name: odontogenesis of dentin-containing tooth is_a: GO:0042476 ! odontogenesis [Term] id: GO:0042476 name: odontogenesis is_a: GO:0009887 ! organ morphogenesis [Term] id: GO:0042481 name: regulation of odontogenesis is_a: GO:2000027 ! regulation of organ morphogenesis [Term] id: GO:0042483 name: negative regulation of odontogenesis is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0051093 ! negative regulation of developmental process [Term] id: GO:0042492 name: gamma-delta T cell differentiation is_a: GO:0030217 ! T cell differentiation is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0042493 name: response to drug is_a: GO:0042221 ! response to chemical [Term] id: GO:0042554 name: superoxide anion generation is_a: GO:0006801 ! superoxide metabolic process [Term] id: GO:0042571 name: immunoglobulin complex, circulating is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0042582 name: azurophil granule is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! secretory granule [Term] id: GO:0042588 name: zymogen granule is_a: GO:0030141 ! secretory granule [Term] id: GO:0042589 name: zymogen granule membrane is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042588 ! zymogen granule [Term] id: GO:0042590 name: antigen processing and presentation of exogenous peptide antigen via MHC class I is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0042592 name: homeostatic process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0042611 name: MHC protein complex is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0042613 name: MHC class II protein complex is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042692 name: muscle cell differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0061061 ! muscle structure development [Term] id: GO:0042698 name: ovulation cycle is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048511 ! rhythmic process is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0042701 name: progesterone secretion is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0035929 ! steroid hormone secretion relationship: part_of GO:0001553 ! luteinization [Term] id: GO:0042742 name: defense response to bacterium is_a: GO:0009617 ! response to bacterium is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0042886 name: amide transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042981 name: regulation of apoptotic process is_a: GO:0043067 ! regulation of programmed cell death [Term] id: GO:0042995 name: cell projection is_a: GO:0044464 ! cell part [Term] id: GO:0043011 name: myeloid dendritic cell differentiation is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation [Term] id: GO:0043062 name: extracellular structure organization is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0043067 name: regulation of programmed cell death is_a: GO:0010941 ! regulation of cell death [Term] id: GO:0043129 name: surfactant homeostasis is_a: GO:0048875 ! chemical homeostasis within a tissue [Term] id: GO:0043134 name: regulation of hindgut contraction is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044058 ! regulation of digestive system process [Term] id: GO:0043170 name: macromolecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043207 name: response to external biotic stimulus is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043208 name: glycosphingolipid binding is_a: GO:0046625 ! sphingolipid binding is_a: GO:0051861 ! glycolipid binding [Term] id: GO:0043226 name: organelle is_a: GO:0005575 ! cellular_component [Term] id: GO:0043227 name: membrane-bounded organelle is_a: GO:0043226 ! organelle [Term] id: GO:0043228 name: non-membrane-bounded organelle is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle is_a: GO:0043226 ! organelle is_a: GO:0044424 ! intracellular part [Term] id: GO:0043230 name: extracellular organelle is_a: GO:0043226 ! organelle is_a: GO:0044421 ! extracellular region part intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005576 ! extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043233 name: organelle lumen is_a: GO:0031974 ! membrane-enclosed lumen is_a: GO:0044422 ! organelle part [Term] id: GO:0043234 name: protein complex is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0043235 name: receptor complex is_a: GO:0043234 ! protein complex [Term] id: GO:0043277 name: apoptotic cell clearance is_a: GO:0006909 ! phagocytosis [Term] id: GO:0043292 name: contractile fiber is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0043368 name: positive T cell selection is_a: GO:0045058 ! T cell selection [Term] id: GO:0043370 name: regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation [Term] id: GO:0043372 name: positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation [Term] id: GO:0043384 name: pre-T cell receptor complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0043436 name: oxoacid metabolic process is_a: GO:0006082 ! organic acid metabolic process [Term] id: GO:0043932 name: ossification involved in bone remodeling is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: part_of GO:0046849 ! bone remodeling relationship: part_of GO:0046849 ! bone remodeling [Term] id: GO:0044057 name: regulation of system process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0044058 name: regulation of digestive system process is_a: GO:0044057 ! regulation of system process [Term] id: GO:0044085 name: cellular component biogenesis is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044237 name: cellular metabolic process is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044260 name: cellular macromolecule metabolic process is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044272 name: sulfur compound biosynthetic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044281 name: small molecule metabolic process is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0044291 name: cell-cell contact zone is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0044421 name: extracellular region part is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005576 ! extracellular region relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0044422 name: organelle part is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0044424 name: intracellular part is_a: GO:0044464 ! cell part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005622 ! intracellular relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0044425 name: membrane part is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane [Term] id: GO:0044427 name: chromosomal part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005694 ! chromosome relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0044428 name: nuclear part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0044431 name: Golgi apparatus part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0044433 name: cytoplasmic vesicle part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0044437 name: vacuolar part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0044441 name: ciliary part is_a: GO:0044422 ! organelle part is_a: GO:0044463 ! cell projection part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005929 ! cilium relationship: part_of GO:0005929 ! cilium [Term] id: GO:0044444 name: cytoplasmic part is_a: GO:0044424 ! intracellular part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0044446 name: intracellular organelle part is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0044449 name: contractile fiber part is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0043292 ! contractile fiber relationship: part_of GO:0043292 ! contractile fiber [Term] id: GO:0044452 name: nucleolar part is_a: GO:0044428 ! nuclear part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005730 ! nucleolus relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0044454 name: nuclear chromosome part is_a: GO:0044427 ! chromosomal part is_a: GO:0044428 ! nuclear part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0000228 ! nuclear chromosome relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0044459 name: plasma membrane part is_a: GO:0044425 ! membrane part is_a: GO:0044464 ! cell part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0044463 name: cell projection part is_a: GO:0044464 ! cell part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0042995 ! cell projection relationship: part_of GO:0042995 ! cell projection [Term] id: GO:0044464 name: cell part is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005623 ! cell relationship: part_of GO:0005623 ! cell [Term] id: GO:0044699 name: single-organism process is_a: GO:0008150 ! biological_process [Term] id: GO:0044700 name: single organism signaling is_a: GO:0023052 ! signaling is_a: GO:0044699 ! single-organism process [Term] id: GO:0044702 name: single organism reproductive process is_a: GO:0022414 ! reproductive process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044703 name: multi-organism reproductive process is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044707 name: single-multicellular organism process is_a: GO:0032501 ! multicellular organismal process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044710 name: single-organism metabolic process is_a: GO:0008152 ! metabolic process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044711 name: single-organism biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0044763 name: single-organism cellular process is_a: GO:0009987 ! cellular process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044765 name: single-organism transport is_a: GO:0006810 ! transport is_a: GO:0044699 ! single-organism process [Term] id: GO:0044767 name: single-organism developmental process is_a: GO:0032502 ! developmental process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044782 name: cilium organization is_a: GO:0030030 ! cell projection organization [Term] id: GO:0045058 name: T cell selection is_a: GO:0002376 ! immune system process relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0045087 name: innate immune response is_a: GO:0006952 ! defense response is_a: GO:0006955 ! immune response [Term] id: GO:0045117 name: azole transport is_a: GO:0015893 ! drug transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0045132 name: meiotic chromosome segregation is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction intersection_of: GO:0007059 ! chromosome segregation intersection_of: part_of GO:0007126 ! meiosis relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0045137 name: development of primary sexual characteristics is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007275 ! multicellular organismal development relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0045144 name: meiotic sister chromatid segregation is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiosis intersection_of: GO:0007059 ! chromosome segregation intersection_of: part_of GO:0007135 ! meiosis II relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0045184 name: establishment of protein localization is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0008104 ! protein localization [Term] id: GO:0045190 name: isotype switching is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0045191 name: regulation of isotype switching is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0050864 ! regulation of B cell activation is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:0045321 name: leukocyte activation is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process [Term] id: GO:0045443 name: juvenile hormone secretion is_a: GO:0046865 ! terpenoid transport is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0045444 name: fat cell differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0045453 name: bone resorption is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0046849 ! bone remodeling [Term] id: GO:0045457 name: ecdysteroid secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0045580 name: regulation of T cell differentiation is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050863 ! regulation of T cell activation [Term] id: GO:0045582 name: positive regulation of T cell differentiation is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0045595 name: regulation of cell differentiation is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0045597 name: positive regulation of cell differentiation is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process [Term] id: GO:0045619 name: regulation of lymphocyte differentiation is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:1902105 ! regulation of leukocyte differentiation [Term] id: GO:0045621 name: positive regulation of lymphocyte differentiation is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1902107 ! positive regulation of leukocyte differentiation [Term] id: GO:0045622 name: regulation of T-helper cell differentiation is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0045624 name: positive regulation of T-helper cell differentiation is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation [Term] id: GO:0045625 name: regulation of T-helper 1 cell differentiation is_a: GO:0002825 ! regulation of T-helper 1 type immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation [Term] id: GO:0045627 name: positive regulation of T-helper 1 cell differentiation is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation [Term] id: GO:0045628 name: regulation of T-helper 2 cell differentiation is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation [Term] id: GO:0045630 name: positive regulation of T-helper 2 cell differentiation is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation [Term] id: GO:0045729 name: respiratory burst at fertilization is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0009566 ! fertilization relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0045730 name: respiratory burst is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development [Term] id: GO:0045766 name: positive regulation of angiogenesis is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0051094 ! positive regulation of developmental process [Term] id: GO:0045830 name: positive regulation of isotype switching is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0050871 ! positive regulation of B cell activation [Term] id: GO:0045911 name: positive regulation of DNA recombination is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051054 ! positive regulation of DNA metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process [Term] id: GO:0046483 name: heterocycle metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0046545 name: development of primary female sexual characteristics is_a: GO:0045137 ! development of primary sexual characteristics relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0046625 name: sphingolipid binding is_a: GO:0008289 ! lipid binding [Term] id: GO:0046629 name: gamma-delta T cell activation is_a: GO:0042110 ! T cell activation [Term] id: GO:0046631 name: alpha-beta T cell activation is_a: GO:0042110 ! T cell activation [Term] id: GO:0046634 name: regulation of alpha-beta T cell activation is_a: GO:0050863 ! regulation of T cell activation [Term] id: GO:0046635 name: positive regulation of alpha-beta T cell activation is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0046637 name: regulation of alpha-beta T cell differentiation is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046634 ! regulation of alpha-beta T cell activation [Term] id: GO:0046638 name: positive regulation of alpha-beta T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation [Term] id: GO:0046649 name: lymphocyte activation is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0046651 name: lymphocyte proliferation is_a: GO:0032943 ! mononuclear cell proliferation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0046660 name: female sex differentiation is_a: GO:0007548 ! sex differentiation relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0046717 name: acid secretion is_a: GO:0046903 ! secretion [Term] id: GO:0046849 name: bone remodeling is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0046864 name: isoprenoid transport is_a: GO:0006869 ! lipid transport [Term] id: GO:0046865 name: terpenoid transport is_a: GO:0046864 ! isoprenoid transport [Term] id: GO:0046879 name: hormone secretion is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release [Term] id: GO:0046903 name: secretion is_a: GO:0044765 ! single-organism transport [Term] id: GO:0046942 name: carboxylic acid transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport [Term] id: GO:0048002 name: antigen processing and presentation of peptide antigen is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0048103 name: somatic stem cell division is_a: GO:0017145 ! stem cell division [Term] id: GO:0048137 name: spermatocyte division is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051301 ! cell division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048232 name: male gamete generation is_a: GO:0007276 ! gamete generation [Term] id: GO:0048240 name: sperm capacitation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048469 ! cell maturation relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0048241 name: epinephrine transport is_a: GO:0009914 ! hormone transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0048242 name: epinephrine secretion is_a: GO:0046879 ! hormone secretion is_a: GO:0048241 ! epinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048243 name: norepinephrine secretion is_a: GO:0015874 ! norepinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048285 name: organelle fission is_a: GO:0006996 ! organelle organization [Term] id: GO:0048293 name: regulation of isotype switching to IgE isotypes is_a: GO:0045191 ! regulation of isotype switching [Term] id: GO:0048295 name: positive regulation of isotype switching to IgE isotypes is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes [Term] id: GO:0048468 name: cell development is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0048469 name: cell maturation is_a: GO:0021700 ! developmental maturation is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048477 name: oogenesis is_a: GO:0007292 ! female gamete generation [Term] id: GO:0048511 name: rhythmic process is_a: GO:0008150 ! biological_process [Term] id: GO:0048513 name: organ development is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development [Term] id: GO:0048515 name: spermatid differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation is_a: GO:0044702 ! single organism reproductive process relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048518 name: positive regulation of biological process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0048519 name: negative regulation of biological process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0048520 name: positive regulation of behavior is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior [Term] id: GO:0048522 name: positive regulation of cellular process is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0048523 name: negative regulation of cellular process is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0048534 name: hematopoietic or lymphoid organ development is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048513 ! organ development relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0048583 name: regulation of response to stimulus is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0048584 name: positive regulation of response to stimulus is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0048608 name: reproductive structure development is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061458 ! reproductive system development [Term] id: GO:0048609 name: multicellular organismal reproductive process is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0048610 name: cellular process involved in reproduction is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0000003 ! reproduction relationship: part_of GO:0000003 ! reproduction [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048666 name: neuron development is_a: GO:0048468 ! cell development relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation is_a: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0048699 name: generation of neurons is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048731 name: system development is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0048738 name: cardiac muscle tissue development is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0048770 name: pigment granule is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0048771 name: tissue remodeling is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0048856 name: anatomical structure development is_a: GO:0032502 ! developmental process [Term] id: GO:0048858 name: cell projection morphogenesis is_a: GO:0030030 ! cell projection organization is_a: GO:0032990 ! cell part morphogenesis relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0048869 name: cellular developmental process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0048870 name: cell motility is_a: GO:0006928 ! cellular component movement is_a: GO:0040011 ! locomotion relationship: part_of GO:0051674 ! localization of cell [Term] id: GO:0048871 name: multicellular organismal homeostasis is_a: GO:0042592 ! homeostatic process is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0048872 name: homeostasis of number of cells is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048873 name: homeostasis of number of cells within a tissue is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0048875 name: chemical homeostasis within a tissue is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0048878 name: chemical homeostasis is_a: GO:0042592 ! homeostatic process [Term] id: GO:0050432 name: catecholamine secretion is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0050670 name: regulation of lymphocyte proliferation is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0050672 name: negative regulation of lymphocyte proliferation is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051250 ! negative regulation of lymphocyte activation [Term] id: GO:0050678 name: regulation of epithelial cell proliferation is_a: GO:0042127 ! regulation of cell proliferation [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation [Term] id: GO:0050708 name: regulation of protein secretion is_a: GO:0051046 ! regulation of secretion is_a: GO:0051223 ! regulation of protein transport is_a: GO:0060341 ! regulation of cellular localization [Term] id: GO:0050714 name: positive regulation of protein secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051222 ! positive regulation of protein transport [Term] id: GO:0050727 name: regulation of inflammatory response is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus [Term] id: GO:0050728 name: negative regulation of inflammatory response is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response [Term] id: GO:0050729 name: positive regulation of inflammatory response is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response [Term] id: GO:0050776 name: regulation of immune response is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0050777 name: negative regulation of immune response is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0050778 name: positive regulation of immune response is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0050789 name: regulation of biological process is_a: GO:0065007 ! biological regulation [Term] id: GO:0050793 name: regulation of developmental process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0050794 name: regulation of cellular process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0050795 name: regulation of behavior is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0050817 name: coagulation is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0050863 name: regulation of T cell activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0050864 name: regulation of B cell activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0050865 name: regulation of cell activation is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0050866 name: negative regulation of cell activation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation [Term] id: GO:0050867 name: positive regulation of cell activation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation [Term] id: GO:0050868 name: negative regulation of T cell activation is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation [Term] id: GO:0050870 name: positive regulation of T cell activation is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0050871 name: positive regulation of B cell activation is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0050877 name: neurological system process is_a: GO:0003008 ! system process [Term] id: GO:0050878 name: regulation of body fluid levels is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050886 name: endocrine process is_a: GO:0003008 ! system process [Term] id: GO:0050896 name: response to stimulus is_a: GO:0008150 ! biological_process [Term] id: GO:0050900 name: leukocyte migration is_a: GO:0002376 ! immune system process is_a: GO:0016477 ! cell migration [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception is_a: GO:0009584 ! detection of visible light is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007601 ! visual perception relationship: part_of GO:0007601 ! visual perception [Term] id: GO:0050909 name: sensory perception of taste is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050910 name: detection of mechanical stimulus involved in sensory perception of sound is_a: GO:0050877 ! neurological system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0007605 ! sensory perception of sound relationship: part_of GO:0007605 ! sensory perception of sound [Term] id: GO:0050911 name: detection of chemical stimulus involved in sensory perception of smell is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0007608 ! sensory perception of smell relationship: part_of GO:0007608 ! sensory perception of smell [Term] id: GO:0050912 name: detection of chemical stimulus involved in sensory perception of taste is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050909 ! sensory perception of taste relationship: part_of GO:0050909 ! sensory perception of taste [Term] id: GO:0050920 name: regulation of chemotaxis is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior [Term] id: GO:0050921 name: positive regulation of chemotaxis is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0050920 ! regulation of chemotaxis [Term] id: GO:0050951 name: sensory perception of temperature stimulus is_a: GO:0007600 ! sensory perception [Term] id: GO:0050953 name: sensory perception of light stimulus is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus is_a: GO:0007600 ! sensory perception [Term] id: GO:0050955 name: thermoception is_a: GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050960 name: detection of temperature stimulus involved in thermoception is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: part_of GO:0050955 ! thermoception relationship: part_of GO:0050955 ! thermoception [Term] id: GO:0050961 name: detection of temperature stimulus involved in sensory perception is_a: GO:0016048 ! detection of temperature stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0050974 name: detection of mechanical stimulus involved in sensory perception is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050982 ! detection of mechanical stimulus intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050975 name: sensory perception of touch is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050976 name: detection of mechanical stimulus involved in sensory perception of touch is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0050975 ! sensory perception of touch relationship: part_of GO:0050975 ! sensory perception of touch [Term] id: GO:0050982 name: detection of mechanical stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0051023 name: regulation of immunoglobulin secretion is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0050708 ! regulation of protein secretion [Term] id: GO:0051024 name: positive regulation of immunoglobulin secretion is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0051023 ! regulation of immunoglobulin secretion [Term] id: GO:0051046 name: regulation of secretion is_a: GO:0051049 ! regulation of transport [Term] id: GO:0051047 name: positive regulation of secretion is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport [Term] id: GO:0051049 name: regulation of transport is_a: GO:0032879 ! regulation of localization [Term] id: GO:0051050 name: positive regulation of transport is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport [Term] id: GO:0051052 name: regulation of DNA metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process [Term] id: GO:0051093 name: negative regulation of developmental process is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0051094 name: positive regulation of developmental process is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0051132 name: NK T cell activation is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0051146 name: striated muscle cell differentiation is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process is_a: GO:0019222 ! regulation of metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process [Term] id: GO:0051179 name: localization is_a: GO:0008150 ! biological_process [Term] id: GO:0051216 name: cartilage development is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0001501 ! skeletal system development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0051222 name: positive regulation of protein transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport [Term] id: GO:0051223 name: regulation of protein transport is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization [Term] id: GO:0051234 name: establishment of localization is_a: GO:0008150 ! biological_process relationship: part_of GO:0051179 ! localization [Term] id: GO:0051239 name: regulation of multicellular organismal process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0051249 name: regulation of lymphocyte activation is_a: GO:0002694 ! regulation of leukocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0051270 name: regulation of cellular component movement is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0051272 name: positive regulation of cellular component movement is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement [Term] id: GO:0051276 name: chromosome organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0051301 name: cell division is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0051321 name: meiotic cell cycle is_a: GO:0007049 ! cell cycle relationship: part_of GO:0000003 ! reproduction [Term] id: GO:0051458 name: corticotropin secretion is_a: GO:0030072 ! peptide hormone secretion is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0051606 name: detection of stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051608 name: histamine transport is_a: GO:0006812 ! cation transport is_a: GO:0045117 ! azole transport [Term] id: GO:0051641 name: cellular localization is_a: GO:0051179 ! localization [Term] id: GO:0051649 name: establishment of localization in cell is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051674 name: localization of cell is_a: GO:0051179 ! localization [Term] id: GO:0051704 name: multi-organism process is_a: GO:0008150 ! biological_process [Term] id: GO:0051707 name: response to other organism is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051716 name: cellular response to stimulus is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051767 name: nitric-oxide synthase biosynthetic process is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051861 name: glycolipid binding is_a: GO:0008289 ! lipid binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0051937 name: catecholamine transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0055007 name: cardiac muscle cell differentiation is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0051146 ! striated muscle cell differentiation relationship: part_of GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055085 name: transmembrane transport is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044765 ! single-organism transport [Term] id: GO:0060047 name: heart contraction is_a: GO:0003015 ! heart process relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0060054 name: positive regulation of epithelial cell proliferation involved in wound healing is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: part_of GO:0042060 ! wound healing relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060089 name: molecular transducer activity is_a: GO:0003674 ! molecular_function [Term] id: GO:0060096 name: serotonin secretion, neurotransmission is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0060097 name: cytoskeletal rearrangement involved in phagocytosis, engulfment is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0007010 ! cytoskeleton organization intersection_of: part_of GO:0006911 ! phagocytosis, engulfment relationship: part_of GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060170 name: ciliary membrane is_a: GO:0031090 ! organelle membrane is_a: GO:0031253 ! cell projection membrane is_a: GO:0044441 ! ciliary part intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005929 ! cilium [Term] id: GO:0060249 name: anatomical structure homeostasis is_a: GO:0042592 ! homeostatic process [Term] id: GO:0060255 name: regulation of macromolecule metabolic process is_a: GO:0019222 ! regulation of metabolic process [Term] id: GO:0060271 name: cilium morphogenesis is_a: GO:0048858 ! cell projection morphogenesis [Term] id: GO:0060326 name: cell chemotaxis is_a: GO:0006935 ! chemotaxis is_a: GO:0016477 ! cell migration is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0060341 name: regulation of cellular localization is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0060374 name: mast cell differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0060429 name: epithelium development is_a: GO:0009888 ! tissue development [Term] id: GO:0060537 name: muscle tissue development is_a: GO:0009888 ! tissue development [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis is_a: GO:0006915 ! apoptotic process is_a: GO:0010623 ! developmental programmed cell death intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0060591 name: chondroblast differentiation is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0060784 name: regulation of cell proliferation involved in tissue homeostasis is_a: GO:0042127 ! regulation of cell proliferation intersection_of: GO:0042127 ! regulation of cell proliferation intersection_of: part_of GO:0001894 ! tissue homeostasis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0060785 name: regulation of apoptosis involved in tissue homeostasis is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0042981 ! regulation of apoptotic process intersection_of: part_of GO:0001894 ! tissue homeostasis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0060786 name: regulation of cell differentiation involved in tissue homeostasis is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0045595 ! regulation of cell differentiation intersection_of: part_of GO:0001894 ! tissue homeostasis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0060973 name: cell migration involved in heart development is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060986 name: endocrine hormone secretion is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0050886 ! endocrine process [Term] id: GO:0061024 name: membrane organization is_a: GO:0016043 ! cellular component organization [Term] id: GO:0061061 name: muscle structure development is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0061448 name: connective tissue development is_a: GO:0009888 ! tissue development [Term] id: GO:0061458 name: reproductive system development is_a: GO:0048731 ! system development [Term] id: GO:0061526 name: acetylcholine secretion is_a: GO:0015870 ! acetylcholine transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0061527 name: dopamine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014046 ! dopamine secretion [Term] id: GO:0061528 name: aspartate secretion is_a: GO:0015810 ! aspartate transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0061529 name: epinephrine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0048242 ! epinephrine secretion [Term] id: GO:0061530 name: aspartate secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061528 ! aspartate secretion [Term] id: GO:0061533 name: norepinephrine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0048243 ! norepinephrine secretion [Term] id: GO:0061534 name: gamma-aminobutyric acid secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0061535 name: glutamate secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014047 ! glutamate secretion [Term] id: GO:0061536 name: glycine secretion is_a: GO:0015816 ! glycine transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0061537 name: glycine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061536 ! glycine secretion [Term] id: GO:0061538 name: histamine secretion, neurotransmission is_a: GO:0001821 ! histamine secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0061539 name: octopamine secretion is_a: GO:0015695 ! organic cation transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0032940 ! secretion by cell is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0061540 name: octopamine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061539 ! octopamine secretion [Term] id: GO:0061544 name: peptide secretion, neurotransmission is_a: GO:0002790 ! peptide secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0065007 name: biological regulation is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality is_a: GO:0065007 ! biological regulation [Term] id: GO:0070013 name: intracellular organelle lumen is_a: GO:0043233 ! organelle lumen is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0070091 name: glucagon secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070192 name: chromosome organization involved in meiosis is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization intersection_of: GO:0051276 ! chromosome organization intersection_of: part_of GO:0007126 ! meiosis relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0070201 name: regulation of establishment of protein localization is_a: GO:0032880 ! regulation of protein localization [Term] id: GO:0070228 name: regulation of lymphocyte apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process [Term] id: GO:0070253 name: somatostatin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070254 name: mucus secretion is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0070278 name: extracellular matrix constituent secretion is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0030198 ! extracellular matrix organization [Term] id: GO:0070459 name: prolactin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070460 name: thyroid-stimulating hormone secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070661 name: leukocyte proliferation is_a: GO:0008283 ! cell proliferation [Term] id: GO:0070663 name: regulation of leukocyte proliferation is_a: GO:0042127 ! regulation of cell proliferation [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation [Term] id: GO:0070727 name: cellular macromolecule localization is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization [Term] id: GO:0070820 name: tertiary granule is_a: GO:0030141 ! secretory granule [Term] id: GO:0070887 name: cellular response to chemical stimulus is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0070925 name: organelle assembly is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0006996 ! organelle organization [Term] id: GO:0070998 name: sensory perception of gravity is_a: GO:0007600 ! sensory perception [Term] id: GO:0070999 name: detection of mechanical stimulus involved in sensory perception of gravity is_a: GO:0009590 ! detection of gravity is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0070998 ! sensory perception of gravity relationship: part_of GO:0070998 ! sensory perception of gravity [Term] id: GO:0071103 name: DNA conformation change is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0071622 name: regulation of granulocyte chemotaxis is_a: GO:0002688 ! regulation of leukocyte chemotaxis [Term] id: GO:0071624 name: positive regulation of granulocyte chemotaxis is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis [Term] id: GO:0071702 name: organic substance transport is_a: GO:0006810 ! transport [Term] id: GO:0071704 name: organic substance metabolic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0071705 name: nitrogen compound transport is_a: GO:0006810 ! transport [Term] id: GO:0071706 name: tumor necrosis factor superfamily cytokine production is_a: GO:0001816 ! cytokine production [Term] id: GO:0071707 name: immunoglobulin heavy chain V-D-J recombination is_a: GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: GO:0071708 name: immunoglobulin light chain V-J recombination is_a: GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: GO:0071735 name: IgG immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071736 name: IgG immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071735 ! IgG immunoglobulin complex [Term] id: GO:0071738 name: IgD immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071739 name: IgD immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071738 ! IgD immunoglobulin complex [Term] id: GO:0071742 name: IgE immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071743 name: IgE immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071742 ! IgE immunoglobulin complex [Term] id: GO:0071745 name: IgA immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071746 name: IgA immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071745 ! IgA immunoglobulin complex [Term] id: GO:0071753 name: IgM immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071754 name: IgM immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071753 ! IgM immunoglobulin complex [Term] id: GO:0071840 name: cellular component organization or biogenesis is_a: GO:0008150 ! biological_process [Term] id: GO:0071912 name: asynchronous neurotransmitter secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0071944 name: cell periphery is_a: GO:0044464 ! cell part [Term] id: GO:0071971 name: extracellular vesicular exosome assembly is_a: GO:0070925 ! organelle assembly [Term] id: GO:0072358 name: cardiovascular system development is_a: GO:0048731 ! system development relationship: part_of GO:0072359 ! circulatory system development [Term] id: GO:0072359 name: circulatory system development is_a: GO:0048731 ! system development [Term] id: GO:0072593 name: reactive oxygen species metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0080090 name: regulation of primary metabolic process is_a: GO:0019222 ! regulation of metabolic process [Term] id: GO:0080134 name: regulation of response to stress is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0090022 name: regulation of neutrophil chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:1902622 ! regulation of neutrophil migration [Term] id: GO:0090023 name: positive regulation of neutrophil chemotaxis is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis is_a: GO:1902624 ! positive regulation of neutrophil migration [Term] id: GO:0090257 name: regulation of muscle system process is_a: GO:0044057 ! regulation of system process [Term] id: GO:0090304 name: nucleic acid metabolic process is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0097014 name: ciliary cytoplasm is_a: GO:0032838 ! cell projection cytoplasm is_a: GO:0044441 ! ciliary part intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005929 ! cilium [Term] id: GO:0097028 name: dendritic cell differentiation is_a: GO:0002521 ! leukocyte differentiation [Term] id: GO:0097159 name: organic cyclic compound binding is_a: GO:0005488 ! binding [Term] id: GO:0097186 name: amelogenesis is_a: GO:0042475 ! odontogenesis of dentin-containing tooth [Term] id: GO:0097194 name: execution phase of apoptosis is_a: GO:0044763 ! single-organism cellular process relationship: part_of GO:0006915 ! apoptotic process [Term] id: GO:0097367 name: carbohydrate derivative binding is_a: GO:0005488 ! binding [Term] id: GO:0097529 name: myeloid leukocyte migration is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0098542 name: defense response to other organism is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism [Term] id: GO:1901135 name: carbohydrate derivative metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:1901342 name: regulation of vasculature development is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:1901360 name: organic cyclic compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901363 name: heterocyclic compound binding is_a: GO:0005488 ! binding [Term] id: GO:1901374 name: acetate ester transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:1901564 name: organonitrogen compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:1901576 name: organic substance biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1902105 name: regulation of leukocyte differentiation is_a: GO:0002682 ! regulation of immune system process is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:1902107 name: positive regulation of leukocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation [Term] id: GO:1902589 name: single-organism organelle organization is_a: GO:0006996 ! organelle organization is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:1902622 name: regulation of neutrophil migration is_a: GO:0002685 ! regulation of leukocyte migration [Term] id: GO:1902624 name: positive regulation of neutrophil migration is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:1902622 ! regulation of neutrophil migration [Term] id: GO:2000026 name: regulation of multicellular organismal development is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:2000027 name: regulation of organ morphogenesis is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process is_a: GO:0042981 ! regulation of apoptotic process [Term] id: GO:2000145 name: regulation of cell motility is_a: GO:0040012 ! regulation of locomotion is_a: GO:0051270 ! regulation of cellular component movement [Term] id: GO:2000147 name: positive regulation of cell motility is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility [Term] id: GO:2000514 name: regulation of CD4-positive, alpha-beta T cell activation is_a: GO:0046634 ! regulation of alpha-beta T cell activation [Term] id: GO:2000516 name: positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation [Term] id: PATO:0000001 name: quality [Term] id: PATO:0000050 name: life span is_a: PATO:0000165 ! time [Term] id: PATO:0000051 name: morphology is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape is_a: PATO:0000051 ! morphology [Term] id: PATO:0000068 name: qualitative is_a: PATO:0000001 ! quality [Term] id: PATO:0000069 name: deviation(from_normal) is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000117 name: size is_a: PATO:0000051 ! morphology [Term] id: PATO:0000165 name: time is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000261 name: maturity is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000406 name: curved is_a: PATO:0001591 ! curvature [Term] id: PATO:0000586 name: increased size is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality [Term] id: PATO:0000587 name: decreased size is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality [Term] id: PATO:0001018 name: physical quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001241 name: physical object quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001367 name: lobate is_a: PATO:0001925 ! surface feature shape [Term] id: PATO:0001374 name: ploidy is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001375 name: haploid is_a: PATO:0001393 ! euploid [Term] id: PATO:0001393 name: euploid is_a: PATO:0001374 ! ploidy [Term] id: PATO:0001394 name: diploid is_a: PATO:0001393 ! euploid [Term] id: PATO:0001396 name: cellular quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001397 name: cellular potency is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001400 name: unipotent is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001401 name: oligopotent is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001402 name: multipotent is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001404 name: nucleate quality is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001405 name: anucleate is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0001406 name: binucleate is_a: PATO:0001908 ! multinucleate [Term] id: PATO:0001407 name: mononucleate is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001410 name: striated is_a: PATO:0000052 ! shape [Term] id: PATO:0001501 name: immature is_a: PATO:0000261 ! maturity [Term] id: PATO:0001591 name: curvature is_a: PATO:0000052 ! shape [Term] id: PATO:0001604 name: decreased life span is_a: PATO:0000050 ! life span is_a: PATO:0002303 ! decreased object quality [Term] id: PATO:0001789 name: domed is_a: PATO:0000406 ! curved [Term] id: PATO:0001857 name: concave is_a: PATO:0002005 ! concavity [Term] id: PATO:0001871 name: reniform is_a: PATO:0002008 ! concave 3-D shape [Term] id: PATO:0001873 name: cylindrical is_a: PATO:0002007 ! convex 3-D shape [Term] id: PATO:0001874 name: discoid is_a: PATO:0001873 ! cylindrical [Term] id: PATO:0001908 name: multinucleate is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001925 name: surface feature shape is_a: PATO:0000052 ! shape [Term] id: PATO:0001979 name: lobed is_a: PATO:0000052 ! shape [Term] id: PATO:0001995 name: organismal quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0002005 name: concavity is_a: PATO:0000052 ! shape [Term] id: PATO:0002007 name: convex 3-D shape is_a: PATO:0002266 ! 3-D shape [Term] id: PATO:0002008 name: concave 3-D shape is_a: PATO:0002266 ! 3-D shape relationship: has_part PATO:0001857 ! concave [Term] id: PATO:0002039 name: biconcave is_a: PATO:0001857 ! concave [Term] id: PATO:0002070 name: affinity is_a: PATO:0002182 ! molecular quality [Term] id: PATO:0002094 name: basophilic is_a: PATO:0002070 ! affinity [Term] id: PATO:0002182 name: molecular quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0002266 name: 3-D shape is_a: PATO:0000052 ! shape [Term] id: PATO:0002300 name: increased quality is_a: PATO:0000069 ! deviation(from_normal) [Term] id: PATO:0002301 name: decreased quality is_a: PATO:0000069 ! deviation(from_normal) [Term] id: PATO:0002303 name: decreased object quality is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality [Term] id: PATO:0002305 name: increased object quality is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality [Term] id: PATO:0002478 name: transversely striated is_a: PATO:0001410 ! striated [Term] id: PATO:0002479 name: obliquely striated is_a: PATO:0001410 ! striated [Term] id: PATO:0002505 name: nucleated is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0002506 name: alobate is_a: PATO:0001925 ! surface feature shape [Term] id: PR:000000001 name: protein namespace: protein def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA." [] comment: Proteins descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]. is_a: PR:000018263 ! amino acid chain [Term] id: PR:000001002 name: CD19 molecule namespace: protein def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte surface antigen B4" EXACT [] synonym: "CD19" EXACT [] synonym: "differentiation antigen CD19" EXACT [] synonym: "T-cell surface antigen Leu-12" EXACT [] xref: PIRSF:PIRSF016630 is_a: PR:000000001 ! protein [Term] id: PR:000001003 name: CD34 molecule namespace: protein def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [] comment: Category=gene. Requested by=CL. synonym: "CD34" EXACT [] synonym: "hematopoietic progenitor cell antigen CD34" EXACT [] xref: PIRSF:PIRSF028749 is_a: PR:000000001 ! protein [Term] id: PR:000001004 name: CD4 molecule namespace: protein def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [] comment: Category=gene. Requested by=CL. synonym: "CD4" EXACT [] synonym: "T-cell differentiation antigen L3T4" EXACT [] synonym: "T-cell surface antigen T4/Leu-3" EXACT [] synonym: "T-cell surface glycoprotein CD4" EXACT [] xref: PIRSF:PIRSF001977 is_a: PR:000000001 ! protein [Term] id: PR:000001005 name: integrin alpha with A domain namespace: protein def: "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (PF00092) (I-domain) of approximately 200 amino acid residues at the N-terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." [] comment: Category=family. synonym: "integrin alpha with I domain" EXACT [] xref: PIRSF:PIRSF002497 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000001006 name: receptor-type tyrosine-protein phosphatase C namespace: protein def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (PF00041) followed by two copies of the Protein-tyrosine phosphatase (PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [] comment: Category=gene. Requested by=CL. synonym: "CD45" EXACT [] synonym: "L-CA" EXACT [] synonym: "leukocyte common antigen" EXACT [] synonym: "ly-5" EXACT [] synonym: "lymphocyte antigen 5" EXACT [] synonym: "PTPRC" EXACT [] synonym: "T200" BROAD [] xref: PIRSF:PIRSF002004 is_a: PR:000000001 ! protein [Term] id: PR:000001008 name: integrin alpha-2 namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGA2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD49 antigen-like family member B" EXACT [] synonym: "CD49b" EXACT [] synonym: "collagen receptor" EXACT [] synonym: "GPIa" EXACT [] synonym: "ITGA2" EXACT [] synonym: "platelet membrane glycoprotein Ia" EXACT [] synonym: "VLA-2 subunit alpha" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001010 name: integrin alpha-E namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAE gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD103" EXACT [] synonym: "HML-1 antigen" EXACT [] synonym: "integrin alpha M290" EXACT [] synonym: "integrin alpha-IEL" EXACT [] synonym: "ITGAE" EXACT [] synonym: "mucosal lymphocyte 1 antigen" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001012 name: integrin alpha-M namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member B" EXACT [] synonym: "CD11b" EXACT [] synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT [] synonym: "CR-3 alpha chain" EXACT [] synonym: "CR3A" RELATED [] synonym: "ITGAM" EXACT [] synonym: "leukocyte adhesion receptor MO1" EXACT [] synonym: "neutrophil adherence receptor" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001013 name: integrin alpha-X namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." [] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member C" EXACT [] synonym: "CD11c" EXACT [] synonym: "ITGAX" EXACT [] synonym: "Leu M5" EXACT [] synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain" EXACT [] synonym: "leukocyte adhesion receptor p150,95" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001014 name: receptor-type tyrosine-protein phosphatase C isoform CD45R namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-1." [] comment: Category=sequence. Requested by=CL. synonym: "B220" RELATED [] synonym: "CD45R" EXACT [] synonym: "CD45RABC" EXACT [] synonym: "PTPRC/iso:CD45R" EXACT [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001015 name: receptor-type tyrosine-protein phosphatase C isoform CD45RA namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C)." [] comment: Category=sequence. Requested by=CL. synonym: "CD45RA" EXACT [] synonym: "PTPRC/iso:CD45RA" EXACT [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001017 name: receptor-type tyrosine-protein phosphatase C isoform CD45RO namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-2." [] comment: Category=sequence. Requested by=CL. synonym: "180 kDa form" EXACT [] synonym: "PTPRC/iso:CD45RO" EXACT [] synonym: "T200" RELATED [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001018 name: CD3 subunit with immunoglobulin domain namespace: protein def: "A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [] comment: Category=family. synonym: "CD3 subunit with Ig-like domain" EXACT [] xref: PIRSF:PIRSF001993 is_a: PR:000000001 ! protein [Term] id: PR:000001020 name: CD3 epsilon namespace: protein def: "A CD3 subunit that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD3E" EXACT [] synonym: "CD3e" EXACT [] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain" EXACT [] synonym: "T3E" RELATED [] is_a: PR:000001018 ! CD3 subunit with immunoglobulin domain [Term] id: PR:000001022 name: neural cell adhesion molecule namespace: protein def: "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." [] comment: Category=family. xref: PIRSF:PIRSF002507 is_a: PR:000000001 ! protein [Term] id: PR:000001023 name: neural cell adhesion molecule NCAM namespace: protein def: "A neural cell adhesion molecule which is involved in neuronal development, synaptic plasticity, and regeneration." [] comment: Category=family. xref: PIRSF:PIRSF501037 is_a: PR:000001022 ! neural cell adhesion molecule [Term] id: PR:000001024 name: neural cell adhesion molecule 1 namespace: protein def: "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD56" EXACT [] synonym: "N-CAM-1" EXACT [] synonym: "NCAM" RELATED [] synonym: "NCAM-1" EXACT [] synonym: "NCAM1" EXACT [] is_a: PR:000001023 ! neural cell adhesion molecule NCAM [Term] id: PR:000001025 name: C-type lectin with multiple lectin domains namespace: protein def: "A protein that is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single Fibronectin type II (FNII) domain (PF00040) and eight to ten copies of the Lectin C-type domain (PF00059) (CTLDs). The presence of multiple copies of the CTLD domain is a hallmark of this class." [] comment: Category=family. xref: PIRSF:PIRSF002427 is_a: PR:000000001 ! protein [Term] id: PR:000001026 name: lymphocyte antigen 75 namespace: protein def: "A C-type lectin with multiple lectin domains that is a translation product of the human LY75 gene or a 1:1 ortholog thereof. It consists of 12 extracellular domains (an N-terminal cysteine-rich domain, a fibronectin type II domain and 10 C-type carbohydrate recognition domains), a transmembrane region and a small cytoplasmic C terminus containing a single Tyr residue, but no obvious kinase domain. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment." [] comment: Category=gene. Requested by=CL. synonym: "C-type lectin domain family 13 member B" EXACT [] synonym: "CD205" EXACT [] synonym: "CLEC13B" RELATED [] synonym: "DEC-205" EXACT [] synonym: "gp200-MR6" EXACT [] synonym: "ly-75" EXACT [] synonym: "LY75" EXACT [] is_a: PR:000001025 ! C-type lectin with multiple lectin domains [Term] id: PR:000001083 name: CD2 molecule namespace: protein def: "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD2" EXACT [] synonym: "erythrocyte receptor" EXACT [] synonym: "LFA-2" EXACT [] synonym: "LFA-3 receptor" EXACT [] synonym: "ly-37" EXACT [] synonym: "lymphocyte antigen 37" EXACT [] synonym: "rosette receptor" EXACT [] synonym: "SRBC" RELATED [] synonym: "T-cell surface antigen CD2" EXACT [] synonym: "T-cell surface antigen T11/Leu-5" EXACT [] synonym: "T-cell surface glycoprotein CD2" EXACT [] xref: PIRSF:PIRSF001984 is_a: PR:000000001 ! protein [Term] id: PR:000001084 name: T-cell surface glycoprotein CD8 alpha chain namespace: protein def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [] comment: Category=gene. Requested by=CL. synonym: "CD8A" EXACT [] synonym: "CD8a" EXACT [] synonym: "Lyt-2" RELATED [] synonym: "Lyt2" RELATED [] synonym: "MAL" RELATED [] synonym: "T-cell surface glycoprotein Lyt-2" EXACT [] synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT [] xref: PANTHER:PTHR10441\:SF1 is_a: PR:000000001 ! protein [Term] id: PR:000001085 name: T-cell surface glycoprotein CD8 beta chain namespace: protein def: "A protein that is a translation product of the human CD8B1 gene or a 1:1 ortholog thereof. CCD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [] comment: Category=gene. synonym: "CD8b" EXACT [] synonym: "CD8B1" EXACT [] synonym: "Ly-3" RELATED [] synonym: "lymphocyte antigen 3" EXACT [] synonym: "Lyt-3" RELATED [] synonym: "Lyt3" RELATED [] synonym: "T-cell membrane glycoprotein Ly-3" EXACT [] synonym: "T-cell surface glycoprotein Lyt-3" EXACT [] xref: PIRSF:PIRSF002020 is_a: PR:000000001 ! protein [Term] id: PR:000001094 name: rhodopsin-like G-protein coupled receptor namespace: protein def: "A protein that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." [] comment: Category=family. synonym: "class 1 G-protein coupled receptor" EXACT [] synonym: "class A G-protein coupled receptor" EXACT [] xref: PIRSF:PIRSF800006 is_a: PR:000000001 ! protein [Term] id: PR:000001128 name: chemokine receptor namespace: protein def: "A rhodopsin-like G protein coupled receptor whose active form binds one or more chemokines. Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list." [] comment: Category=family. xref: PIRSF:PIRSF038545 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001197 name: chemokine receptor CCR1/3/1L namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the CCR1, CCR3, or CCR1L1 genes (the last found so far only in mouse)." [] comment: Category=family. xref: PIRSF:PIRSF501024 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001199 name: C-C chemokine receptor type 2 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-2" EXACT [] synonym: "CC-CKR-2" EXACT [] synonym: "CCR-2" EXACT [] synonym: "CCR2" EXACT [] synonym: "CD192" EXACT [] synonym: "chemokine receptor CCR2" EXACT [] synonym: "CMKBR2" RELATED [] synonym: "JE/FIC receptor" EXACT [] synonym: "MCP-1 receptor" EXACT [] synonym: "MCP-1-R" EXACT [] synonym: "monocyte chemoattractant protein 1 receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001200 name: C-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR4 gene or a 1:1 ortholog thereof. The preferred ligands include CCL17 and CCL22." [] comment: Category=gene. synonym: "C-C CKR-4" EXACT [] synonym: "CC-CKR-4" EXACT [] synonym: "CCR-4" EXACT [] synonym: "CCR4" EXACT [] synonym: "CD194" EXACT [] synonym: "chemokine receptor CCR4" EXACT [] synonym: "CMKBR4" RELATED [] synonym: "K5-5" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001201 name: C-C chemokine receptor type 5 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR5 gene or a 1:1 ortholog thereof. The preferred ligands include CCL3, CCL4, CCL5, CCL8, CCL14." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-5" EXACT [] synonym: "CC-CKR-5" EXACT [] synonym: "CCR-5" EXACT [] synonym: "CCR5" EXACT [] synonym: "CD195" EXACT [] synonym: "chemokine receptor CCR5" EXACT [] synonym: "CHEMR13" EXACT [] synonym: "CMKBR5" RELATED [] synonym: "HIV-1 fusion coreceptor" EXACT [] synonym: "MIP-1 alpha receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001202 name: C-C chemokine receptor type 6 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-6" EXACT [] synonym: "CC-CKR-6" EXACT [] synonym: "CCR-6" EXACT [] synonym: "CCR6" EXACT [] synonym: "CD196" EXACT [] synonym: "chemokine receptor CCR6" EXACT [] synonym: "chemokine receptor-like 3" EXACT [] synonym: "CKR-L3" EXACT [] synonym: "CKRL3" RELATED [] synonym: "CMKBR6" RELATED [] synonym: "DRY6" EXACT [] synonym: "G-protein coupled receptor 29" EXACT [] synonym: "GPR-CY4" EXACT [] synonym: "GPR29" RELATED [] synonym: "GPRCY4" EXACT [] synonym: "KY411" EXACT [] synonym: "LARC receptor" EXACT [] synonym: "STRL22" RELATED [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001203 name: C-C chemokine receptor type 7 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." [] comment: Category=gene. Requested by=CL. synonym: "BLR2" EXACT [] synonym: "C-C CKR-7" EXACT [] synonym: "CC-CKR-7" EXACT [] synonym: "CCR-7" EXACT [] synonym: "CCR7" EXACT [] synonym: "CD197" EXACT [] synonym: "CDw197" EXACT [] synonym: "chemokine receptor CCR7" EXACT [] synonym: "CMKBR7" RELATED [] synonym: "EBI1" EXACT [] synonym: "Ebi1h" RELATED [] synonym: "EBV-induced G-protein coupled receptor 1" EXACT [] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1" EXACT [] synonym: "EVI1" RELATED [] synonym: "MIP-3 beta receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001206 name: CX3C chemokine receptor 1 namespace: protein def: "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." [] comment: Category=gene. Requested by=CL. synonym: "beta chemokine receptor-like 1" EXACT [] synonym: "C-X3-C CKR-1" EXACT [] synonym: "chemokine receptor CX3CR1" EXACT [] synonym: "CMK-BRL-1" EXACT [] synonym: "CMK-BRL1" EXACT [] synonym: "CMKBRL1" RELATED [] synonym: "CX3CR1" EXACT [] synonym: "fractalkine receptor" EXACT [] synonym: "G-protein coupled receptor 13" EXACT [] synonym: "GPR13" RELATED [] synonym: "V28" EXACT [] xref: PIRSF:PIRSF501025 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001207 name: C-X-C chemokine receptor type 3 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR3 gene or a 1:1 ortholog thereof. The preferred ligands include CXCL9, CXCL10, CXCL11." [] comment: Category=gene. synonym: "CD183" EXACT [] synonym: "chemokine receptor CXCR3" EXACT [] synonym: "CKR-L2" EXACT [] synonym: "Cmkar3" RELATED [] synonym: "CXC-R3" EXACT [] synonym: "CXCR-3" EXACT [] synonym: "CXCR3" EXACT [] synonym: "G-protein coupled receptor 9" EXACT [] synonym: "GPR9" RELATED [] synonym: "interferon-inducible protein 10 receptor" EXACT [] synonym: "IP-10 receptor" EXACT [] xref: PIRSF:PIRSF501023 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001208 name: C-X-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12." [] comment: Category=gene. Requested by=CL. synonym: "CD184" EXACT [] synonym: "chemokine receptor CXCR4" EXACT [] synonym: "Cmkar4" RELATED [] synonym: "CXC-R4" EXACT [] synonym: "CXCR-4" EXACT [] synonym: "CXCR4" EXACT [] synonym: "FB22" EXACT [] synonym: "fusin" EXACT [] synonym: "HM89" EXACT [] synonym: "LCR1" EXACT [] synonym: "LESTR" EXACT [] synonym: "leukocyte-derived seven transmembrane domain receptor" EXACT [] synonym: "NPYRL" EXACT [] synonym: "PB-CKR" EXACT [] synonym: "pre-B-cell-derived chemokine receptor" EXACT [] synonym: "SDF-1 receptor" EXACT [] synonym: "Sdf1r" RELATED [] synonym: "stromal cell-derived factor 1 receptor" EXACT [] xref: PIRSF:PIRSF501021 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001209 name: C-X-C chemokine receptor type 5 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR5 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL13." [] comment: Category=gene. Requested by=CL. synonym: "BLR1" RELATED [] synonym: "burkitt lymphoma receptor 1" EXACT [] synonym: "burkitt lymphoma receptor 1 homolog" EXACT [] synonym: "CD185" EXACT [] synonym: "chemokine receptor CXCR5" EXACT [] synonym: "CXC-R5" EXACT [] synonym: "CXCR-5" EXACT [] synonym: "CXCR5" EXACT [] synonym: "Gpcr6" RELATED [] synonym: "MDR-15" EXACT [] synonym: "MDR15" RELATED [] synonym: "monocyte-derived receptor 15" EXACT [] xref: PANTHER:PTHR24227\:SF213 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001226 name: high affinity interleukin-8 receptor namespace: protein def: "A chemokine receptor whose active form binds interleukin-8 with high affinity." [] comment: Category=family. xref: PIRSF:PIRSF501022 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001254 name: chemokine receptor CCR1 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-1" EXACT [] synonym: "CC-CKR-1" EXACT [] synonym: "CCR-1" EXACT [] synonym: "CCR1" EXACT [] synonym: "CD191" EXACT [] synonym: "CMKBR1" RELATED [] synonym: "CMKR1" RELATED [] synonym: "HM145" EXACT [] synonym: "LD78 receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor" EXACT [] synonym: "MIP-1alpha-R" EXACT [] synonym: "RANTES-R" EXACT [] synonym: "SCYAR1" RELATED [] is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001255 name: chemokine receptor CCR3 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-3" EXACT [] synonym: "CC-CKR-3" EXACT [] synonym: "CCR-3" EXACT [] synonym: "CCR3" EXACT [] synonym: "CD193" EXACT [] synonym: "CKR3" EXACT [] synonym: "Cmkbr1l2" RELATED [] synonym: "CMKBR3" RELATED [] synonym: "eosinophil eotaxin receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT [] synonym: "MIP-1 alpha RL2" EXACT [] is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001256 name: high affinity interleukin-8 receptor A namespace: protein def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD181" EXACT [] synonym: "CDw128a" EXACT [] synonym: "CMKAR1" RELATED [] synonym: "CXC-R1" EXACT [] synonym: "CXCR-1" EXACT [] synonym: "CXCR1" EXACT [] synonym: "IL-8 receptor type 1" EXACT [] synonym: "IL-8R A" EXACT [] synonym: "IL8RA" RELATED [] is_a: PR:000001226 ! high affinity interleukin-8 receptor [Term] id: PR:000001257 name: high affinity interleukin-8 receptor B namespace: protein def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD182" EXACT [] synonym: "CDw128b" EXACT [] synonym: "Cmkar2" RELATED [] synonym: "CXC-R2" EXACT [] synonym: "CXCR-2" EXACT [] synonym: "CXCR2" EXACT [] synonym: "Gpcr16" RELATED [] synonym: "GRO/MGSA receptor" EXACT [] synonym: "IL-8 receptor type 2" EXACT [] synonym: "IL-8R B" EXACT [] synonym: "IL8RB" RELATED [] is_a: PR:000001226 ! high affinity interleukin-8 receptor [Term] id: PR:000001281 name: ADP-ribosyl cyclase namespace: protein def: "A protein that contains the ADP-ribosyl cyclase domain (PF02267)." [] comment: Category=family. xref: PIRSF:PIRSF005736 is_a: PR:000000001 ! protein [Term] id: PR:000001288 name: B-cell receptor CD22 namespace: protein def: "A protein that is a translation product of the human CD22 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte cell adhesion molecule" EXACT [] synonym: "BL-CAM" EXACT [] synonym: "CD22" EXACT [] synonym: "Lyb-8" RELATED [] synonym: "sialic acid-binding Ig-like lectin 2" EXACT [] synonym: "siglec-2" EXACT [] synonym: "SIGLEC2" RELATED [] synonym: "T-cell surface antigen Leu-14" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001289 name: membrane-spanning 4-domains subfamily A member 1 namespace: protein def: "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen Ly-44" EXACT [] synonym: "B-cell surface antigen CD20" EXACT [] synonym: "B-lymphocyte antigen CD20" EXACT [] synonym: "B-lymphocyte surface antigen B1" EXACT [] synonym: "Bp35" EXACT [] synonym: "CD20" EXACT [] synonym: "leukocyte surface antigen Leu-16" EXACT [] synonym: "Ly-44" RELATED [] synonym: "lymphocyte antigen 44" EXACT [] synonym: "MS4A1" EXACT [] synonym: "Ms4a2" RELATED [] xref: PIRSF:PIRSF001995 is_a: PR:000000001 ! protein [Term] id: PR:000001290 name: B7-related protein namespace: protein def: "A protein that is a member of a family that includes translation products of genes CD86, CD276, ICOSLG, and others. These are membrane-anchored proteins with a small intracellular domain and an extracellular domain with signal sequence, an Immunoglobulin V-set domain (PF07686), and a CD80-like C2-set immunoglobulin domain (PF08205)." [] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000001292 name: C-type lectin domain family 4 member C namespace: protein def: "A protein that is a translation product of the human CLEC4C gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "BDCA-2" EXACT [] synonym: "BDCA2" RELATED [] synonym: "blood dendritic cell antigen 2" EXACT [] synonym: "C-type lectin superfamily member 7" EXACT [] synonym: "CD303" EXACT [] synonym: "CLEC4C" EXACT [] synonym: "CLECSF11" RELATED [] synonym: "CLECSF7" RELATED [] synonym: "dendritic lectin" EXACT [] synonym: "DLEC" RELATED [] synonym: "HECL" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001293 name: C-type lectin domain family 4 member K namespace: protein def: "A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD207" EXACT [] synonym: "CLEC4K" RELATED [] synonym: "langerin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001300 name: CD209 molecule namespace: protein def: "A protein that is a translation product of the human CD209 gene or a 1:1 ortholog thereof." [] comment: Category=gene. This gene and CLEC4M are products of a recent gene duplication in the primate lineage. Independent duplications of an ancestral gene have given rise to several orthologs in rodents, including CD209A. Requested by=CL. synonym: "C-type lectin domain family 4 member L" EXACT [] synonym: "CD209" EXACT [] synonym: "CD209 antigen" EXACT [] synonym: "CLEC4L" RELATED [] synonym: "DC-SIGN" RELATED [] synonym: "DC-SIGN1" EXACT [] synonym: "dendritic cell-specific ICAM-3-grabbing non-integrin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001307 name: CD44 molecule namespace: protein def: "A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD44" EXACT [] synonym: "CD44 antigen" EXACT [] synonym: "CDw44" EXACT [] synonym: "ECMR-III" EXACT [] synonym: "epican" EXACT [] synonym: "extracellular matrix receptor III" EXACT [] synonym: "GP90 lymphocyte homing/adhesion receptor" EXACT [] synonym: "heparan sulfate proteoglycan" EXACT [] synonym: "hermes antigen" EXACT [] synonym: "HUTCH-I" EXACT [] synonym: "hyaluronate receptor" EXACT [] synonym: "LHR" RELATED [] synonym: "ly-24" EXACT [] synonym: "lymphocyte antigen 24" EXACT [] synonym: "MDU2" RELATED [] synonym: "MDU3" RELATED [] synonym: "MIC4" RELATED [] synonym: "PGP-1" EXACT [] synonym: "PGP-I" RELATED [] synonym: "phagocytic glycoprotein 1" EXACT [] synonym: "phagocytic glycoprotein I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001308 name: CD48 molecule namespace: protein def: "A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte activation marker BLAST-1" EXACT [] synonym: "Bcm-1" RELATED [] synonym: "BCM1" RELATED [] synonym: "BCM1 surface antigen" EXACT [] synonym: "BLAST-1" EXACT [] synonym: "BLAST1" RELATED [] synonym: "CD48" EXACT [] synonym: "CD48 antigen" EXACT [] synonym: "HM48-1" EXACT [] synonym: "leukocyte antigen MEM-102" EXACT [] synonym: "MRC OX-45 surface antigen" EXACT [] synonym: "sgp-60" EXACT [] synonym: "TCT.1" EXACT [] xref: PANTHER:PTHR12080\:SF3 xref: PIRSF:PIRSF001973 is_a: PR:000000001 ! protein [Term] id: PR:000001310 name: CD83 molecule namespace: protein def: "A protein that is a translation product of the human CD83 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell activation protein" EXACT [] synonym: "CD83" EXACT [] synonym: "CD83 antigen" EXACT [] synonym: "cell surface protein HB15" EXACT [] synonym: "hCD83" BROAD [] is_a: PR:000000001 ! protein [Term] id: PR:000001318 name: L-selectin namespace: protein def: "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." [] comment: Category=gene. Requested by=CL. synonym: "CD62 antigen-like family member L" EXACT [] synonym: "CD62L" EXACT [] synonym: "gp90-MEL" EXACT [] synonym: "LAM-1" EXACT [] synonym: "LECAM1" EXACT [] synonym: "leukocyte adhesion molecule 1" EXACT [] synonym: "leukocyte surface antigen Leu-8" EXACT [] synonym: "leukocyte-endothelial cell adhesion molecule 1" EXACT [] synonym: "LNHR" RELATED [] synonym: "ly-22" EXACT [] synonym: "Ly22" RELATED [] synonym: "LYAM1" RELATED [] synonym: "lymph node homing receptor" EXACT [] synonym: "lymphocyte antigen 22" EXACT [] synonym: "lymphocyte surface MEL-14 antigen" EXACT [] synonym: "SELL" EXACT [] synonym: "TQ1" EXACT [] xref: PIRSF:PIRSF002421 is_a: PR:000000001 ! protein [Term] id: PR:000001319 name: SLAM family member 5 namespace: protein def: "A protein that is a translation product of the human CD84 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD84" EXACT [] synonym: "cell surface antigen MAX.3" EXACT [] synonym: "hly9-beta" EXACT [] synonym: "leukocyte differentiation antigen CD84" EXACT [] synonym: "signaling lymphocytic activation molecule 5" EXACT [] synonym: "SLAMF5" RELATED [] xref: PANTHER:PTHR12080\:SF6 is_a: PR:000000001 ! protein [Term] id: PR:000001320 name: alpha-(1,3)-fucosyltransferase namespace: protein def: "A protein that is a stand alone version of the Glycosyltransferase family 10 (fucosyltransferase) (PF00852) domain. Proteins in this class may catalyze alpha-1,3 glycosidic linkages." [] comment: Category=family. xref: PIRSF:PIRSF005726 is_a: PR:000000001 ! protein [Term] id: PR:000001326 name: bone marrow stromal antigen 2 namespace: protein def: "A protein that is a translation product of the human BST2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "BST-2" EXACT [] synonym: "BST2" EXACT [] synonym: "CD317" EXACT [] synonym: "HM1.24 antigen" EXACT [] synonym: "tetherin" EXACT [] xref: PIRSF:PIRSF023920 is_a: PR:000000001 ! protein [Term] id: PR:000001327 name: cadherin namespace: protein def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (PF00028), a transmembrane region, and a Cadherin cytoplasmic region (PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [] comment: Category=family. xref: PIRSF:PIRSF002504 is_a: PR:000000001 ! protein [Term] id: PR:000001332 name: carcinoembryonic antigen-related cell adhesion molecule 8 namespace: protein def: "A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "carcinoembryonic antigen CGM6" EXACT [] synonym: "CD66b" EXACT [] synonym: "CD67 antigen" EXACT [] synonym: "CEACAM8" EXACT [] synonym: "CGM6" RELATED [] synonym: "non-specific cross-reacting antigen NCA-95" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001337 name: complement receptor type 1 namespace: protein def: "A protein that is a translation product of the human CR1 gene or a 1:1 ortholog thereof. There is no counterpart in mouse." [] comment: Category=gene. Requested by=CL. synonym: "C3b/C4b receptor" EXACT [] synonym: "C3BR" RELATED [] synonym: "CD35" EXACT [] synonym: "CR1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001338 name: complement receptor type 2 namespace: protein def: "A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C3DR" RELATED [] synonym: "CD21" EXACT [] synonym: "complement C3d receptor" EXACT [] synonym: "CR2" EXACT [] synonym: "Cr2" EXACT [] synonym: "EBV receptor" EXACT [] synonym: "epstein-Barr virus receptor" EXACT [] xref: PIRSF:PIRSF002484 is_a: PR:000000001 ! protein [Term] id: PR:000001343 name: CD69 molecule namespace: protein def: "A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets." [] comment: Category=gene. Requested by=CL. synonym: "activation inducer molecule" EXACT [] synonym: "AIM" EXACT [] synonym: "BL-AC/P26" EXACT [] synonym: "C-type lectin domain family 2 member C" EXACT [] synonym: "CD69" EXACT [] synonym: "CLEC2C" RELATED [] synonym: "EA1" EXACT [] synonym: "early activation antigen CD69" EXACT [] synonym: "early T-cell activation antigen p60" EXACT [] synonym: "GP32/28" EXACT [] synonym: "leukocyte surface antigen Leu-23" EXACT [] synonym: "MLR-3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001344 name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 namespace: protein def: "A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD203c" EXACT [] synonym: "E-NPP 3" EXACT [] synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 3" EXACT [] synonym: "ENPP3" EXACT [] synonym: "PD-Ibeta" EXACT [] synonym: "PDNP3" RELATED [] synonym: "phosphodiesterase I beta" EXACT [] synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001345 name: endoglin namespace: protein def: "A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD105" EXACT [] synonym: "cell surface MJ7/18 antigen" EXACT [] synonym: "Edg" RELATED [] synonym: "END" RELATED [] synonym: "ENG" EXACT [] xref: PIRSF:PIRSF038746 is_a: PR:000000001 ! protein [Term] id: PR:000001350 name: forkhead box protein P3 namespace: protein def: "A protein that is a translation product of the human FOXP3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "FOXP3" EXACT [] synonym: "IPEX" RELATED [] synonym: "scurfin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001352 name: glycophorin namespace: protein def: "A protein that contains an extracellular Glycophorin A domain (PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane." [] comment: Category=family. xref: PIRSF:PIRSF002466 is_a: PR:000000001 ! protein [Term] id: PR:000001355 name: immunoglobulin gamma Fc receptor II/III/IV namespace: protein def: "A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III." [] comment: Category=family. xref: PIRSF:PIRSF001980 is_a: PR:000000001 ! protein [Term] id: PR:000001356 name: immunoglobulin gamma Fc receptor I namespace: protein def: "A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in humans." [] comment: Category=family. synonym: "Fc-gamma receptor" RELATED [] xref: PIRSF:PIRSF001981 is_a: PR:000000001 ! protein [Term] id: PR:000001380 name: interleukin-2 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD25" EXACT [] synonym: "IL-2 receptor subunit alpha" EXACT [] synonym: "IL-2-RA" EXACT [] synonym: "IL-2R subunit alpha" EXACT [] synonym: "IL2-RA" EXACT [] synonym: "Il2r" RELATED [] synonym: "IL2RA" EXACT [] synonym: "p55" RELATED [] synonym: "TAC antigen" EXACT [] xref: PIRSF:PIRSF001954 is_a: PR:000000001 ! protein [Term] id: PR:000001381 name: interleukin-2 receptor subunit beta namespace: protein def: "A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD122" EXACT [] synonym: "high affinity IL-2 receptor subunit beta" EXACT [] synonym: "IL-2 receptor subunit beta" EXACT [] synonym: "IL-2R subunit beta" EXACT [] synonym: "IL-2RB" EXACT [] synonym: "IL2RB" EXACT [] synonym: "p70-75" EXACT [] synonym: "p75" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001398 name: leukocyte immunoglobulin-like receptor subfamily A member 4 namespace: protein def: "A protein that is a translation product of the human LILRA4 gene or a 1:1 ortholog thereof. This gene is a member of a lineage-specific gene expansion in primates." [] comment: Category=gene. Requested by=CL. synonym: "CD85 antigen-like family member G" EXACT [] synonym: "CD85g" EXACT [] synonym: "ILT-7" EXACT [] synonym: "ILT7" RELATED [] synonym: "immunoglobulin-like transcript 7" EXACT [] synonym: "LILRA4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001402 name: killer cell lectin-like receptor subfamily D member 1 namespace: protein def: "A protein that is a translation product of the human KLRD1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD94" EXACT [] synonym: "KLRD1" EXACT [] synonym: "KP43" EXACT [] synonym: "natural killer cells antigen CD94" EXACT [] synonym: "NK cell receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001403 name: tetraspanin namespace: protein def: "A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least 4 cysteine residues, including a highly conserved 'CCG' motif." [] comment: Category=family. xref: PIRSF:PIRSF002419 is_a: PR:000000001 ! protein [Term] id: PR:000001408 name: ADP-ribosyl cyclase 1 namespace: protein def: "An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cADPr hydrolase 1" EXACT [] synonym: "CD38" EXACT [] synonym: "cyclic ADP-ribose hydrolase 1" EXACT [] synonym: "I-19" EXACT [] synonym: "NIM-R5 antigen" EXACT [] synonym: "T10" EXACT [] is_a: PR:000001281 ! ADP-ribosyl cyclase [Term] id: PR:000001412 name: CD86 molecule namespace: protein def: "A B7-related protein that is a translation product of the human CD86 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activation B7-2 antigen" EXACT [] synonym: "B70" EXACT [] synonym: "BU63" EXACT [] synonym: "CD28LG2" RELATED [] synonym: "CD86" EXACT [] synonym: "CD86 antigen" EXACT [] synonym: "CTLA-4 counter-receptor B7.2" EXACT [] synonym: "early T-cell costimulatory molecule 1" EXACT [] synonym: "ETC-1" EXACT [] synonym: "FUN-1" EXACT [] synonym: "T-lymphocyte activation antigen CD86" EXACT [] xref: PANTHER:PTHR25462\:SF45 is_a: PR:000001290 ! B7-related protein [Term] id: PR:000001431 name: N-formyl peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the FPR1, FPR2, or FPR3 gene and whose active form binds N-formyl methionyl peptides." [] comment: Category=family. xref: PIRSF:PIRSF038561 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001438 name: CD80 molecule namespace: protein def: "A B7-related protein that is a translation product of the human CD80 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activation B7-1 antigen" EXACT [] synonym: "B7" EXACT [] synonym: "BB1" EXACT [] synonym: "CD28LG" RELATED [] synonym: "CD28LG1" RELATED [] synonym: "CD80" EXACT [] synonym: "CTLA-4 counter-receptor B7.1" EXACT [] synonym: "LAB7" RELATED [] synonym: "T-lymphocyte activation antigen CD80" EXACT [] is_a: PR:000001290 ! B7-related protein [Term] id: PR:000001444 name: cadherin-5 namespace: protein def: "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "7B4 antigen" EXACT [] synonym: "CD144" EXACT [] synonym: "CDH5" EXACT [] synonym: "vascular endothelial cadherin" EXACT [] synonym: "VE-cadherin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001447 name: epithelial cadherin namespace: protein def: "A cadherin that is a translation product of the human CDH1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ARC-1" EXACT [] synonym: "CAM 120/80" EXACT [] synonym: "CD324" EXACT [] synonym: "CDH1" EXACT [] synonym: "CDHE" RELATED [] synonym: "E-cadherin" EXACT [] synonym: "UVO" RELATED [] synonym: "uvomorulin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001456 name: alpha-(1,3)-fucosyltransferase FUT4 namespace: protein def: "A fucosyltransferase that is a translation product of the human FUT4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD15" EXACT [] synonym: "ELAM-1 ligand fucosyltransferase" EXACT [] synonym: "ELFT" RELATED [] synonym: "FCT3A" RELATED [] synonym: "Fuc-TIV" EXACT [] synonym: "fucosyltransferase 4" EXACT [] synonym: "fucosyltransferase FUT4" EXACT [] synonym: "fucosyltransferase IV" EXACT [] synonym: "FucT-IV" EXACT [] synonym: "FUT4" EXACT [] synonym: "galactoside 3-L-fucosyltransferase" BROAD [] is_a: PR:000001320 ! alpha-(1,3)-fucosyltransferase [Term] id: PR:000001460 name: glycophorin-A namespace: protein def: "A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain." [] comment: Category=gene. Requested by=CL. synonym: "CD235a" EXACT [] synonym: "GPA" RELATED [] synonym: "GYPA" EXACT [] synonym: "MN sialoglycoprotein" EXACT [] synonym: "PAS-2" EXACT [] synonym: "sialoglycoprotein alpha" EXACT [] is_a: PR:000001352 ! glycophorin [Term] id: PR:000001465 name: high affinity immunoglobulin gamma Fc receptor I namespace: protein def: "An immunoglobulin gamma Fc receptor I that is a translation product of the human FCGR1A gene or a 1:1 ortholog thereof." [] comment: Category=gene. The Fcgr1 gene in mouse is a 1:1 ortholog of FCGR1A, not FCGR1B. Requested by=CL. synonym: "CD64" EXACT [] synonym: "Fc-gamma RI" EXACT [] synonym: "FCG1" RELATED [] synonym: "FCGR1" RELATED [] synonym: "FCGR1A" EXACT [] synonym: "FcRI" EXACT [] synonym: "IGFR1" RELATED [] synonym: "IgG Fc receptor I" EXACT [] is_a: PR:000001356 ! immunoglobulin gamma Fc receptor I [Term] id: PR:000001479 name: low affinity immunoglobulin gamma Fc region receptor II namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD32" BROAD [] synonym: "Fc gamma receptor IIB" EXACT [] synonym: "Fc-gamma RII" EXACT [] synonym: "Fc-gamma-RIIB" EXACT [] synonym: "Fcgr2" EXACT [] synonym: "Fcgr2b" RELATED [] synonym: "FcRII" EXACT [] synonym: "IgG Fc receptor II beta" EXACT [] synonym: "ly-17" EXACT [] synonym: "lymphocyte antigen 17" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001481 name: low affinity immunoglobulin gamma Fc region receptor II-b namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD32" BROAD [] synonym: "CDw32" BROAD [] synonym: "Fc-gamma RII-b" EXACT [] synonym: "Fc-gamma-RIIb" EXACT [] synonym: "FCG2" RELATED [] synonym: "FCGR2B" EXACT [] synonym: "FcRII-b" EXACT [] synonym: "IGFR2" RELATED [] synonym: "IgG Fc receptor II-b" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001483 name: low affinity immunoglobulin gamma Fc region receptor III namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD16" EXACT [] synonym: "Fc-gamma RIII" EXACT [] synonym: "Fcgr3" EXACT [] synonym: "FcRIII" EXACT [] synonym: "IgG Fc receptor III" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001580 name: fMet-Leu-Phe receptor namespace: protein def: "An N-formyl peptide receptor that is a translation product of the human FPR1 gene or a 1:1 ortholog thereof. The preferred ligand is the peptide fMet-Leu-Phe, a bacterial peptide that acts as a chemoattractant in various pathophysiological conditions." [] comment: Category=gene. Requested by=CL. synonym: "fMLP receptor" EXACT [] synonym: "FPR" EXACT [] synonym: "FPR1" EXACT [] synonym: "N-formyl peptide receptor" BROAD [] synonym: "N-formylpeptide chemoattractant receptor" EXACT [] is_a: PR:000001431 ! N-formyl peptide receptor [Term] id: PR:000001753 name: transcription factor NF-kappa-B subunit namespace: protein def: "A protein with a core domain composition consisting of a Rel homology domain (RHD) (PF00554), an IPT/TIG domain (PF01833), six copies of the Ankyrin repeat (PF00023), a Death domain (PF00531) and a C-terminal PEST region." [] comment: Category=family. synonym: "transcription factor NF-kappa-B" RELATED [] xref: PIRSF:PIRSF036310 is_a: PR:000000001 ! protein [Term] id: PR:000001785 name: prominin namespace: protein def: "A protein with core architecture consisting of one Prominin (PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and Homo sapiens prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain." [] comment: Category=family. xref: PANTHER:PTHR22730 xref: PIRSF:PIRSF017831 is_a: PR:000000001 ! protein [Term] id: PR:000001786 name: prominin-1 namespace: protein def: "A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "antigen AC133" EXACT [] synonym: "antigen AC133 homolog" EXACT [] synonym: "CD133" EXACT [] synonym: "Prom" RELATED [] synonym: "PROM1" EXACT [] synonym: "prominin-like protein 1" EXACT [] synonym: "PROML1" RELATED [] is_a: PR:000001785 ! prominin [Term] id: PR:000001800 name: 5'-nucleotidase namespace: protein def: "A protein that is a translation product of the human NT5E gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "5'-NT" EXACT [] synonym: "CD73" EXACT [] synonym: "ecto-5'-nucleotidase" EXACT [] synonym: "NT5" RELATED [] synonym: "NT5E" EXACT [] synonym: "NTE" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001806 name: C-type lectin domain family 6 member A namespace: protein def: "A protein that is a translation product of the human CLEC6A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-type lectin superfamily member 10" EXACT [] synonym: "Clec4n" RELATED [] synonym: "CLEC6A" EXACT [] synonym: "CLECSF10" RELATED [] synonym: "DC-associated C-type lectin 2" EXACT [] synonym: "dectin-2" EXACT [] synonym: "DECTIN2" RELATED [] synonym: "dendritic cell-associated C-type lectin 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001807 name: C-type lectin domain family 7 member A namespace: protein def: "A protein that is a translation product of the human CLEC7A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "beta-glucan receptor" EXACT [] synonym: "BGR" RELATED [] synonym: "C-type lectin superfamily member 12" EXACT [] synonym: "CLEC7A" EXACT [] synonym: "CLECSF12" RELATED [] synonym: "DC-associated C-type lectin 1" EXACT [] synonym: "dectin-1" EXACT [] synonym: "DECTIN1" RELATED [] synonym: "dendritic cell-associated C-type lectin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001809 name: CD59-like glycoprotein namespace: protein def: "A protein that is a translation product of the CD59 or closely related gene. This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues." [] comment: Category=family. Requested by=CL. xref: PIRSF:PIRSF038782 is_a: PR:000000001 ! protein [Term] id: PR:000001810 name: CSF-1/PDGF receptor-type tyrosine-protein kinase namespace: protein def: "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. PF00047 is most common, but other members of the Ig domain clan, PF07679 and PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." [] comment: Category=family. xref: PIRSF:PIRSF000615 is_a: PR:000000001 ! protein [Term] id: PR:000001813 name: EGF-like module-containing mucin-like hormone receptor-like 1 namespace: protein def: "A protein that is a translation product of the human EMR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cell surface glycoprotein F4/80" EXACT [] synonym: "EGF-like module receptor 1" EXACT [] synonym: "EMR1" EXACT [] synonym: "EMR1 hormone receptor" EXACT [] synonym: "Gpf480" RELATED [] synonym: "TM7LN3" RELATED [] xref: PIRSF:PIRSF038685 is_a: PR:000000001 ! protein [Term] id: PR:000001820 name: MHC class II histocompatibility antigen alpha chain namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, an alpha domain (PF00993) and an Immunoglobulin C1-set domain (PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region. There are three major and two minor class II MHC (major histocompatability complex) alpha chain genes in humans. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants. In contrast to MHC Class I alpha chain genes, orthologies can be seem between some human and mouse genes. MHC class II alpha chains form heterodimers with MHLC class II beta chains." [] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000001832 name: SIRP/SHPS-1 family protein namespace: protein def: "A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (PF07686), two Immunoglobulin C1-set domains (PF07654), a single-pass transmembrane region and a very small cytoplasmic region." [] comment: Category=family. xref: PIRSF:PIRSF038063 is_a: PR:000000001 ! protein [Term] id: PR:000001833 name: SLAM family member 1 namespace: protein def: "A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD150" EXACT [] synonym: "CDw150" EXACT [] synonym: "IPO-3" EXACT [] synonym: "SLAM" RELATED [] synonym: "SLAMF1" EXACT [] xref: PANTHER:PTHR12080\:SF1 is_a: PR:000000001 ! protein [Term] id: PR:000001835 name: T-box transcription factor TBX21 namespace: protein def: "A protein that is a translation product of the human TBX21 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "T-box protein 21" EXACT [] synonym: "T-cell-specific T-box transcription factor T-bet" EXACT [] synonym: "TBET" RELATED [] synonym: "TBLYM" RELATED [] synonym: "TBX21" EXACT [] synonym: "transcription factor TBLYM" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001836 name: CD7 molecule namespace: protein def: "A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD7" EXACT [] synonym: "GP40" EXACT [] synonym: "T-cell antigen CD7" EXACT [] synonym: "T-cell leukemia antigen" EXACT [] synonym: "T-cell surface antigen Leu-9" EXACT [] synonym: "TP41" EXACT [] xref: PIRSF:PIRSF038791 is_a: PR:000000001 ! protein [Term] id: PR:000001838 name: T-cell surface glycoprotein CD1 namespace: protein def: "A protein with core architecture consisting of a signal sequence, an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (PF00129) and an Immunoglobulin C1-set domain (PF07654), a single-pass transmembrane region, and a very short cytoplasmic region. Forms a heterodimer with beta-2 microglobulin." [] comment: Category=family. xref: PIRSF:PIRSF038798 is_a: PR:000000001 ! protein [Term] id: PR:000001839 name: T-cell surface glycoprotein CD5 namespace: protein def: "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD5" EXACT [] synonym: "LEU1" RELATED [] synonym: "ly-1" EXACT [] synonym: "lymphocyte antigen 1" EXACT [] synonym: "lymphocyte antigen T1/Leu-1" EXACT [] synonym: "Lyt-1" EXACT [] xref: PANTHER:PTHR19331\:SF6 is_a: PR:000000001 ! protein [Term] id: PR:000001841 name: T-cell-specific surface glycoprotein CD28 namespace: protein def: "A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD28" EXACT [] synonym: "TP44" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001843 name: Thy-1 membrane glycoprotein namespace: protein def: "A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD90" EXACT [] synonym: "CDw90" EXACT [] synonym: "Thy-1" RELATED [] synonym: "Thy-1 antigen" EXACT [] synonym: "THY1" EXACT [] xref: PIRSF:PIRSF038777 is_a: PR:000000001 ! protein [Term] id: PR:000001844 name: arginase-1 namespace: protein def: "A protein that is a translation product of the human ARG1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ARG1" EXACT [] synonym: "liver-type arginase" EXACT [] synonym: "type I arginase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001850 name: cathepsin K namespace: protein def: "A protein that is a translation product of the human CTSK gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cathepsin O" RELATED [] synonym: "cathepsin O2" EXACT [] synonym: "cathepsin X" RELATED [] synonym: "CTSK" EXACT [] synonym: "CTSO" RELATED [] synonym: "CTSO2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001852 name: cytotoxic T-lymphocyte protein 4 namespace: protein def: "A protein that is a translation product of the human CTLA4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD152" EXACT [] synonym: "CTLA-4" EXACT [] synonym: "CTLA4" EXACT [] synonym: "cytotoxic T-lymphocyte-associated antigen 4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001858 name: immunoglobulin iota chain namespace: protein def: "A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells." [] comment: Category=gene. Requested by=CL. synonym: "CD179 antigen-like family member A" EXACT [] synonym: "CD179a" EXACT [] synonym: "protein VPreB1" EXACT [] synonym: "V(pre)B protein" EXACT [] synonym: "VPREB" RELATED [] synonym: "VpreB protein" EXACT [] synonym: "VPREB1" EXACT [] xref: PIRSF:PIRSF038787 is_a: PR:000000001 ! protein [Term] id: PR:000001859 name: immunoglobulin lambda-like polypeptide 1 namespace: protein def: "A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD179 antigen-like family member B" EXACT [] synonym: "CD179b" EXACT [] synonym: "Ig lambda-5" EXACT [] synonym: "Igl-5" RELATED [] synonym: "IGL1" RELATED [] synonym: "IGLL1" EXACT [] synonym: "immunoglobulin omega polypeptide" EXACT [] synonym: "immunoglobulin-related protein 14.1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001860 name: inducible T-cell costimulator namespace: protein def: "A protein that is a translation product of the human ICOS gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activation-inducible lymphocyte immunomediatory molecule" EXACT [] synonym: "AILIM" RELATED [] synonym: "CCLP" EXACT [] synonym: "CD278" EXACT [] synonym: "CD28 and CTLA-4-like protein" EXACT [] synonym: "CD28-related protein 1" EXACT [] synonym: "CRP-1" RELATED [] synonym: "ICOS" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001861 name: integrin beta namespace: protein def: "A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (PF00362), up to four EGF-like domains (PF07974), and an Integrin beta tail domain (PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (PF08725)." [] comment: Category=family. xref: PIRSF:PIRSF002512 is_a: PR:000000001 ! protein [Term] id: PR:000001865 name: interleukin-3 receptor class 2 alpha chain namespace: protein def: "A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD123" EXACT [] synonym: "IL-3 receptor subunit alpha" EXACT [] synonym: "IL-3R subunit alpha" EXACT [] synonym: "IL-3R-alpha" EXACT [] synonym: "IL-3RA" EXACT [] synonym: "IL3R" RELATED [] synonym: "IL3RA" EXACT [] synonym: "interleukin-3 receptor class II alpha chain" EXACT [] synonym: "Sut-1" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001867 name: interleukin-5 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD125" EXACT [] synonym: "CDw125" EXACT [] synonym: "IL-5 receptor subunit alpha" EXACT [] synonym: "IL-5R subunit alpha" EXACT [] synonym: "IL-5R-alpha" EXACT [] synonym: "IL-5RA" EXACT [] synonym: "IL5R" RELATED [] synonym: "IL5RA" EXACT [] xref: PIRSF:PIRSF018419 is_a: PR:000000001 ! protein [Term] id: PR:000001869 name: interleukin-7 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD127" EXACT [] synonym: "CDw127" EXACT [] synonym: "IL-7 receptor subunit alpha" EXACT [] synonym: "IL-7R subunit alpha" EXACT [] synonym: "IL-7R-alpha" EXACT [] synonym: "IL-7RA" EXACT [] synonym: "IL7R" EXACT [] xref: PIRSF:PIRSF001960 is_a: PR:000000001 ! protein [Term] id: PR:000001874 name: KLRB1-like protein namespace: protein def: "A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat." [] comment: Category=family. Requested by=CL. xref: PIRSF:PIRSF038804 is_a: PR:000000001 ! protein [Term] id: PR:000001879 name: leukosialin namespace: protein def: "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen LP-3" EXACT [] synonym: "CD43" EXACT [] synonym: "galactoglycoprotein" EXACT [] synonym: "GALGP" EXACT [] synonym: "leukocyte sialoglycoprotein" EXACT [] synonym: "ly-48" EXACT [] synonym: "lymphocyte antigen 48" EXACT [] synonym: "sialophorin" EXACT [] synonym: "SPN" EXACT [] xref: PIRSF:PIRSF001994 is_a: PR:000000001 ! protein [Term] id: PR:000001880 name: low affinity immunoglobulin epsilon Fc receptor namespace: protein def: "A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "BLAST-2" EXACT [] synonym: "C-type lectin domain family 4 member J" EXACT [] synonym: "CD23" EXACT [] synonym: "CD23A" RELATED [] synonym: "CLEC4J" RELATED [] synonym: "Fc-epsilon-RII" EXACT [] synonym: "FCE2" RELATED [] synonym: "FCER2" EXACT [] synonym: "Fcer2a" RELATED [] synonym: "IGEBF" RELATED [] synonym: "immunoglobulin E-binding factor" EXACT [] synonym: "lymphocyte IgE receptor" EXACT [] xref: PIRSF:PIRSF002426 is_a: PR:000000001 ! protein [Term] id: PR:000001883 name: lysosome-associated membrane protein namespace: protein def: "A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane." [] comment: Category=family. xref: PIRSF:PIRSF002462 is_a: PR:000000001 ! protein [Term] id: PR:000001884 name: macrophage receptor MARCO namespace: protein def: "A protein that is a translation product of the human MARCO gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "macrophage receptor with collagenous structure" EXACT [] synonym: "MARCO" EXACT [] synonym: "SCARA2" RELATED [] synonym: "scavenger receptor class A member 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001885 name: macrophage scavenger receptor types I and II namespace: protein def: "A protein that is a translation product of the human MSR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD204" EXACT [] synonym: "macrophage acetylated LDL receptor I and II" EXACT [] synonym: "MSR1" EXACT [] synonym: "SCARA1" RELATED [] synonym: "scavenger receptor class A member 1" EXACT [] synonym: "scavenger receptor type A" EXACT [] synonym: "Scvr" RELATED [] synonym: "SR-A" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001888 name: membrane alanyl aminopeptidase-like metallopeptidase namespace: protein def: "A protein with core architecture consisting of a Peptidase family M1 domain (PF01433)." [] comment: Category=family. xref: PIRSF:PIRSF005502 is_a: PR:000000001 ! protein [Term] id: PR:000001889 name: CD14 molecule namespace: protein def: "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD14" EXACT [] synonym: "monocyte differentiation antigen CD14" EXACT [] synonym: "myeloid cell-specific leucine-rich glycoprotein" EXACT [] xref: PIRSF:PIRSF002017 is_a: PR:000000001 ! protein [Term] id: PR:000001892 name: CD33 molecule namespace: protein def: "A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD33" EXACT [] synonym: "gp67" EXACT [] synonym: "myeloid cell surface antigen CD33" EXACT [] synonym: "sialic acid-binding Ig-like lectin 3" EXACT [] synonym: "siglec-3" EXACT [] synonym: "SIGLEC3" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001893 name: natural cytotoxicity triggering receptor 1 namespace: protein def: "A protein that is a translation product of the human NCR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activating receptor 1" EXACT [] synonym: "CD335" EXACT [] synonym: "hNKp46" EXACT [] synonym: "LY94" RELATED [] synonym: "lymphocyte antigen 94" EXACT [] synonym: "lymphocyte antigen 94 homolog" EXACT [] synonym: "mAR-1" EXACT [] synonym: "mNKp46" EXACT [] synonym: "natural killer cell p46-related protein" EXACT [] synonym: "NCR1" EXACT [] synonym: "NK cell-activating receptor" BROAD [] synonym: "NK-p46" EXACT [] synonym: "NKp46" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001896 name: natural killer cell receptor 2B4 namespace: protein def: "A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "2B4" RELATED [] synonym: "CD244" EXACT [] synonym: "h2B4" EXACT [] synonym: "NAIL" EXACT [] synonym: "NK cell activation-inducing ligand" EXACT [] synonym: "NK cell type I receptor protein 2B4" EXACT [] synonym: "NKR2B4" EXACT [] synonym: "Nmrk" RELATED [] synonym: "non-MHC restricted killing associated" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001897 name: natural killer cell receptor NKG2 namespace: protein def: "A protein with core architecture consisting of an as yet unnamed domain in the amino-terminal half and a carboxyl-terminal Lectin C-type domain (PF00059)." [] comment: Category=family. xref: PIRSF:PIRSF005558 is_a: PR:000000001 ! protein [Term] id: PR:000001898 name: neprilysin namespace: protein def: "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "atriopeptidase" EXACT [] synonym: "CALLA" EXACT [] synonym: "CD10" EXACT [] synonym: "common acute lymphocytic leukemia antigen" EXACT [] synonym: "enkephalinase" EXACT [] synonym: "EPN" RELATED [] synonym: "MME" EXACT [] synonym: "NEP" EXACT [] synonym: "neutral endopeptidase" EXACT [] synonym: "neutral endopeptidase 24.11" EXACT [] xref: PIRSF:PIRSF501074 is_a: PR:000000001 ! protein [Term] id: PR:000001902 name: nuclear receptor ROR-gamma namespace: protein def: "A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof." [] comment: Category=gene. synonym: "NR1F3" RELATED [] synonym: "nuclear receptor RZR-gamma" EXACT [] synonym: "nuclear receptor subfamily 1 group F member 3" EXACT [] synonym: "retinoid-related orphan receptor-gamma" EXACT [] synonym: "RORC" EXACT [] synonym: "RORG" RELATED [] synonym: "RZRG" RELATED [] synonym: "Thor" RELATED [] synonym: "thymus orphan receptor" EXACT [] synonym: "TOR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001903 name: paired box protein PAX-5 namespace: protein def: "A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell-specific transcription factor" EXACT [] synonym: "BSAP" EXACT [] synonym: "Pax-5" RELATED [] synonym: "PAX5" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001905 name: platelet glycoprotein 4 namespace: protein def: "A protein that is a translation product of the human CD36 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD36" EXACT [] synonym: "FAT" EXACT [] synonym: "fatty acid translocase" EXACT [] synonym: "glycoprotein IIIb" EXACT [] synonym: "GP3B" RELATED [] synonym: "GP4" RELATED [] synonym: "GPIIIB" EXACT [] synonym: "GPIV" EXACT [] synonym: "leukocyte differentiation antigen CD36" EXACT [] synonym: "PAS IV" EXACT [] synonym: "PAS-4" EXACT [] synonym: "platelet collagen receptor" EXACT [] synonym: "platelet glycoprotein IV" EXACT [] synonym: "thrombospondin receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001907 name: platelet glycoprotein Ib alpha chain namespace: protein def: "A protein that is a translation product of the human GP1BA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "antigen CD42b-alpha" EXACT [] synonym: "CD42b" EXACT [] synonym: "glycoprotein Ibalpha" EXACT [] synonym: "GP-Ib alpha" EXACT [] synonym: "GP1BA" EXACT [] synonym: "GPIb-alpha" EXACT [] synonym: "GPIbA" EXACT [] xref: PIRSF:PIRSF002493 is_a: PR:000000001 ! protein [Term] id: PR:000001919 name: programmed cell death protein 1 namespace: protein def: "A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD279" EXACT [] synonym: "hPD-1" EXACT [] synonym: "mPD-1" EXACT [] synonym: "PD1" RELATED [] synonym: "PDCD1" EXACT [] synonym: "protein PD-1" EXACT [] xref: PIRSF:PIRSF018380 is_a: PR:000000001 ! protein [Term] id: PR:000001925 name: scavenger receptor cysteine-rich type 1 protein M130 namespace: protein def: "A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD163" EXACT [] synonym: "hemoglobin scavenger receptor" EXACT [] synonym: "M130" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001927 name: sialic acid-binding Ig-like lectin 5 namespace: protein def: "A protein that is a translation product of the human SIGLEC5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD170" EXACT [] synonym: "CD33 antigen-like 2" EXACT [] synonym: "CD33L2" RELATED [] synonym: "mSiglec-F" EXACT [] synonym: "OB-binding protein 2" EXACT [] synonym: "OB-BP2" EXACT [] synonym: "OBBP2" RELATED [] synonym: "obesity-binding protein 2" EXACT [] synonym: "sialic acid-binding Ig-like lectin F" EXACT [] synonym: "siglec-5" EXACT [] synonym: "siglec-F" EXACT [] synonym: "SIGLEC5" EXACT [] synonym: "Siglecf" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001931 name: sialoadhesin namespace: protein def: "A protein that is a translation product of the human SIGLEC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD169" EXACT [] synonym: "Sa" RELATED [] synonym: "SER" EXACT [] synonym: "sheep erythrocyte receptor" EXACT [] synonym: "sialic acid-binding Ig-like lectin 1" EXACT [] synonym: "siglec-1" EXACT [] synonym: "SIGLEC1" EXACT [] synonym: "SN" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001932 name: signal transducer CD24 namespace: protein def: "A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof." [] comment: Category=gene. The mouse ortholog is Cd24a. Mouse protein Cd24b likely also orthologous. Currently it is not in UniProt. Requested by=CL. synonym: "CD24" EXACT [] synonym: "CD24A" RELATED [] synonym: "HSA" EXACT [] synonym: "ly-52" EXACT [] synonym: "lymphocyte antigen 52" EXACT [] synonym: "M1/69-J11D heat stable antigen" EXACT [] synonym: "nectadrin" EXACT [] synonym: "R13-Ag" EXACT [] synonym: "small cell lung carcinoma cluster 4 antigen" EXACT [] synonym: "X62 heat stable antigen" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001935 name: syndecan-1 namespace: protein def: "A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD138" EXACT [] synonym: "SDC" RELATED [] synonym: "SDC1" EXACT [] synonym: "Synd-1" RELATED [] synonym: "SYND1" EXACT [] xref: PIRSF:PIRSF015854 is_a: PR:000000001 ! protein [Term] id: PR:000001937 name: tartrate-resistant acid phosphatase type 5 namespace: protein def: "A protein that is a translation product of the human ACP5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ACP5" EXACT [] synonym: "T5ap" RELATED [] synonym: "tartrate-resistant acid ATPase" EXACT [] synonym: "TR-AP" EXACT [] synonym: "Trap" RELATED [] synonym: "TrATPase" EXACT [] synonym: "type 5 acid phosphatase" EXACT [] xref: PIRSF:PIRSF000898 is_a: PR:000000001 ! protein [Term] id: PR:000001938 name: thrombomodulin-like receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (PF00059), 5 or 6 EGF-like domains (PF00008, PF09064, or PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids)." [] comment: Category=family. xref: PIRSF:PIRSF001775 is_a: PR:000000001 ! protein [Term] id: PR:000001941 name: trans-acting T-cell-specific transcription factor GATA-3 namespace: protein def: "A protein that is a translation product of the human GATA3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Gata-3" RELATED [] synonym: "GATA-binding factor 3" EXACT [] synonym: "GATA3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001944 name: transcription factor PU.1 namespace: protein def: "A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "31 kDa-transforming protein" EXACT [] synonym: "SFFV proviral integration 1 protein" EXACT [] synonym: "Sfpi-1" RELATED [] synonym: "Sfpi1" RELATED [] synonym: "SPI1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001945 name: transferrin receptor protein 1 namespace: protein def: "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD71" EXACT [] synonym: "p90" RELATED [] synonym: "T9" EXACT [] synonym: "TfR" EXACT [] synonym: "TfR1" EXACT [] synonym: "TFRC" EXACT [] synonym: "TR" RELATED [] synonym: "Trfr" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001950 name: tumor necrosis factor ligand superfamily member 5 namespace: protein def: "A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD154" EXACT [] synonym: "CD40-L" EXACT [] synonym: "CD40L" RELATED [] synonym: "CD40LG" EXACT [] synonym: "T-cell antigen Gp39" EXACT [] synonym: "TNF-related activation protein" EXACT [] synonym: "TNFSF5" RELATED [] synonym: "TRAP" BROAD [] xref: PIRSF:PIRSF016527 is_a: PR:000000001 ! protein [Term] id: PR:000001954 name: tumor necrosis factor receptor superfamily member 11A namespace: protein def: "A protein that is a translation product of the human TNFRSF11A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD265" EXACT [] synonym: "ODFR" EXACT [] synonym: "osteoclast differentiation factor receptor" EXACT [] synonym: "RANK" RELATED [] synonym: "receptor activator of NF-KB" EXACT [] synonym: "TNFRSF11A" EXACT [] xref: PIRSF:PIRSF038806 is_a: PR:000000001 ! protein [Term] id: PR:000001963 name: CD27 molecule namespace: protein def: "A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD27" EXACT [] synonym: "CD27L receptor" EXACT [] synonym: "T-cell activation antigen CD27" EXACT [] synonym: "T14" EXACT [] synonym: "TNFRSF7" RELATED [] xref: PIRSF:PIRSF001966 is_a: PR:000000001 ! protein [Term] id: PR:000001968 name: tyrosine-protein phosphatase non-receptor type substrate 1 namespace: protein def: "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Bit" EXACT [] synonym: "brain Ig-like molecule with tyrosine-based activation motifs" EXACT [] synonym: "CD172 antigen-like family member A" EXACT [] synonym: "CD172a" EXACT [] synonym: "inhibitory receptor SHPS-1" EXACT [] synonym: "macrophage fusion receptor" EXACT [] synonym: "MFR" RELATED [] synonym: "mSIRP-alpha1" EXACT [] synonym: "MyD-1 antigen" EXACT [] synonym: "MYD1" RELATED [] synonym: "p84" EXACT [] synonym: "PTPNS1" RELATED [] synonym: "SHP substrate 1" EXACT [] synonym: "SHPS-1" EXACT [] synonym: "SHPS1" RELATED [] synonym: "signal-regulatory protein alpha-1" EXACT [] synonym: "signal-regulatory protein alpha-2" EXACT [] synonym: "signal-regulatory protein alpha-3" EXACT [] synonym: "SIRP" RELATED [] synonym: "Sirp-alpha-1" EXACT [] synonym: "Sirp-alpha-2" EXACT [] synonym: "Sirp-alpha-3" EXACT [] synonym: "SIRPA" EXACT [] is_a: PR:000001832 ! SIRP/SHPS-1 family protein [Term] id: PR:000001969 name: urokinase plasminogen activator surface receptor namespace: protein def: "A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD87" EXACT [] synonym: "MO3" RELATED [] synonym: "monocyte activation antigen Mo3" EXACT [] synonym: "PLAUR" EXACT [] synonym: "U-PAR" EXACT [] synonym: "uPAR" EXACT [] xref: PIRSF:PIRSF002022 is_a: PR:000000001 ! protein [Term] id: PR:000001971 name: vascular endothelial growth factor receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (PF00047, PF07679, or PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [] comment: Category=family. xref: PIRSF:PIRSF038502 is_a: PR:000000001 ! protein [Term] id: PR:000002001 name: receptor-type tyrosine-protein kinase FLT3 namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD135" EXACT [] synonym: "fetal liver kinase 2" EXACT [] synonym: "FLK-2" EXACT [] synonym: "FLT-3" EXACT [] synonym: "FLT3" EXACT [] synonym: "Fms-like tyrosine kinase 3" EXACT [] synonym: "stem cell tyrosine kinase 1" EXACT [] synonym: "STK-1" RELATED [] synonym: "STK1" RELATED [] synonym: "tyrosine-protein kinase FLT3" EXACT [] synonym: "tyrosine-protein kinase receptor flk-2" EXACT [] synonym: "tyrosine-protein kinase receptor FLT3" EXACT [] xref: PIRSF:PIRSF500949 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002015 name: MHC class II histocompatibility antigen alpha chain HLA-DRA namespace: protein def: "An MHC class II histocompatibility antigen alpha chain that is a translation product of the human HLA-DRA gene or a 1:1 ortholog thereof." [] comment: Category=gene. The mouse ortholog is called H2-EA. synonym: "H2-Ea" RELATED [] synonym: "H2-IE-alpha" EXACT [] synonym: "HLA-DRA" EXACT [] synonym: "HLA-DRA1" RELATED [] synonym: "MHC class II antigen DRA" EXACT [] is_a: PR:000001820 ! MHC class II histocompatibility antigen alpha chain [Term] id: PR:000002023 name: NKG2-A/NKG2-B type II integral membrane protein namespace: protein def: "A natural killer cell receptor NKG2 that is a translation product of the human KLRC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD159 antigen-like family member A" EXACT [] synonym: "CD159a" EXACT [] synonym: "KLRC1" EXACT [] synonym: "NK cell receptor A" EXACT [] synonym: "NKG2-A/B-activating NK receptor" EXACT [] synonym: "NKG2A" RELATED [] is_a: PR:000001897 ! natural killer cell receptor NKG2 [Term] id: PR:000002025 name: T-cell surface glycoprotein CD1a namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD1A" EXACT [] synonym: "CD1a" EXACT [] synonym: "hTa1 thymocyte antigen" EXACT [] synonym: "T-cell surface antigen T6/Leu-6" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002027 name: T-cell surface glycoprotein CD1c namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1C gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD1C" EXACT [] synonym: "CD1c" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002028 name: T-cell surface glycoprotein CD1d namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1D gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Cd1.1" RELATED [] synonym: "CD1D" EXACT [] synonym: "CD1d" EXACT [] synonym: "CD1d.1" EXACT [] synonym: "Cd1d1" RELATED [] synonym: "R3G1" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002031 name: aminopeptidase N namespace: protein def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ANPEP gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "alanyl aminopeptidase" EXACT [] synonym: "aminopeptidase M" EXACT [] synonym: "ANPEP" EXACT [] synonym: "AP-M" EXACT [] synonym: "AP-N" EXACT [] synonym: "APN" RELATED [] synonym: "CD13" EXACT [] synonym: "gp150" EXACT [] synonym: "hAPN" EXACT [] synonym: "Lap-1" RELATED [] synonym: "Lap1" RELATED [] synonym: "mAPN" EXACT [] synonym: "membrane protein p161" EXACT [] synonym: "microsomal aminopeptidase" EXACT [] synonym: "myeloid plasma membrane glycoprotein CD13" EXACT [] synonym: "PEPN" RELATED [] is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase [Term] id: PR:000002037 name: complement component C1q receptor namespace: protein def: "A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Aa4" RELATED [] synonym: "C1q/MBL/SPA receptor" EXACT [] synonym: "C1qR" EXACT [] synonym: "C1qR(p)" EXACT [] synonym: "C1QR1" RELATED [] synonym: "C1qRp" EXACT [] synonym: "CD93" EXACT [] synonym: "CDw93" EXACT [] synonym: "cell surface antigen AA4" EXACT [] synonym: "complement component 1 q subcomponent receptor 1" EXACT [] synonym: "ly-68" EXACT [] synonym: "Ly68" RELATED [] synonym: "lymphocyte antigen 68" EXACT [] synonym: "matrix-remodeling-associated protein 4" EXACT [] synonym: "MXRA4" RELATED [] is_a: PR:000001938 ! thrombomodulin-like receptor [Term] id: PR:000002039 name: glutamyl aminopeptidase namespace: protein def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "aminopeptidase A" EXACT [] synonym: "AP-A" EXACT [] synonym: "BP-1/6C3 antigen" EXACT [] synonym: "CD249" EXACT [] synonym: "differentiation antigen gp160" EXACT [] synonym: "EAP" RELATED [] synonym: "ENPEP" EXACT [] is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase [Term] id: PR:000002062 name: macrophage colony-stimulating factor 1 receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD115" EXACT [] synonym: "CSF-1-R" EXACT [] synonym: "CSF1R" EXACT [] synonym: "Csfmr" RELATED [] synonym: "FMS" RELATED [] synonym: "proto-oncogene c-Fms" EXACT [] xref: PIRSF:PIRSF500947 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002064 name: macrosialin namespace: protein def: "A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD68" EXACT [] synonym: "gp110" RELATED [] is_a: PR:000001883 ! lysosome-associated membrane protein [Term] id: PR:000002065 name: mast/stem cell growth factor receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD117" EXACT [] synonym: "KIT" EXACT [] synonym: "proto-oncogene c-Kit" EXACT [] synonym: "SCFR" EXACT [] synonym: "Sl" RELATED [] synonym: "tyrosine-protein kinase Kit" EXACT [] xref: PIRSF:PIRSF500951 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002105 name: thrombomodulin namespace: protein def: "A thrombomodulin-like receptor that is a translation product of the human THBD gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD141" EXACT [] synonym: "fetomodulin" EXACT [] synonym: "THBD" EXACT [] synonym: "THRM" RELATED [] synonym: "TM" EXACT [] is_a: PR:000001938 ! thrombomodulin-like receptor [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD309" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "FLK-1" EXACT [] synonym: "FLK1" RELATED [] synonym: "KDR" EXACT [] synonym: "kinase insert domain receptor" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] synonym: "VEGFR-2" EXACT [] is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000002972 name: macrophage mannose receptor 1 namespace: protein def: "A C-type lectin with multiple lectin domains that is a translation product of the human MRC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-type lectin domain family 13 member D" EXACT [] synonym: "C-type lectin domain family 13 member D-like" RELATED [] synonym: "CD206" EXACT [] synonym: "CLEC13D" RELATED [] synonym: "CLEC13DL" RELATED [] synonym: "macrophage mannose receptor 1-like protein 1" RELATED [] synonym: "MMR" EXACT [] synonym: "MRC1" EXACT [] synonym: "MRC1L1" RELATED [] is_a: PR:000001025 ! C-type lectin with multiple lectin domains [Term] id: PR:000002976 name: ly-6-like protein namespace: protein def: "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." [] comment: Category=family. xref: PIRSF:PIRSF002021 is_a: PR:000000001 ! protein [Term] id: PR:000002977 name: killer cell lectin-like receptor subfamily B member 1C namespace: protein alt_id: PR:000009625 def: "A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD161 antigen-like family member C" EXACT [] synonym: "CD161c" EXACT [] synonym: "Klrb1c" EXACT [] synonym: "ly-55c" EXACT [] synonym: "Ly55c" RELATED [] synonym: "lymphocyte antigen 55c" EXACT [] synonym: "natural killer cell surface protein P1-40" EXACT [] synonym: "NK1.1" EXACT [] synonym: "NKR-P1 40" EXACT [] synonym: "NKR-P1.9" EXACT [] synonym: "NKR-P1C" EXACT [] synonym: "Nkrp1c" RELATED [] is_a: PR:000001874 ! KLRB1-like protein [Term] id: PR:000002978 name: lymphocyte antigen 6G namespace: protein def: "A ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ly-6G" EXACT [] synonym: "ly-6G.1" EXACT [] synonym: "Ly6g" EXACT [] is_a: PR:000002976 ! ly-6-like protein [Term] id: PR:000002979 name: lymphocyte antigen 6A-2/6E-1 namespace: protein def: "A ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ly-6A.2/Ly-6E.1" EXACT [] synonym: "Ly6" RELATED [] synonym: "Ly6a" EXACT [] synonym: "SCA-1" RELATED [] synonym: "stem cell antigen 1" EXACT [] synonym: "T-cell-activating protein" EXACT [] synonym: "TAP" RELATED [] is_a: PR:000002976 ! ly-6-like protein [Term] id: PR:000002980 name: lymphocyte antigen 6C2 namespace: protein def: "An ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ly-6C2" EXACT [] synonym: "Ly6c" RELATED [] synonym: "Ly6c2" EXACT [] is_a: PR:000002976 ! ly-6-like protein [Term] id: PR:000002981 name: lymphocyte antigen 76 namespace: protein def: "A protein that is a translation product of the mouse Ly76 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Ly76" EXACT [] synonym: "ter-119" EXACT [] synonym: "ter119" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003450 name: B-cell lymphoma 6 protein namespace: protein alt_id: PR:000004700 def: "A protein that is a translation product of the human BCL6 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell lymphoma 5 protein" EXACT [] synonym: "BCL-5" EXACT [] synonym: "BCL-6" EXACT [] synonym: "BCL5" RELATED [] synonym: "BCL6" EXACT [] synonym: "LAZ3" RELATED [] synonym: "protein LAZ-3" EXACT [] synonym: "ZBTB27" RELATED [] synonym: "zinc finger and BTB domain-containing protein 27" EXACT [] synonym: "zinc finger protein 51" EXACT [] synonym: "ZNF51" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003455 name: nuclear receptor ROR-gamma isoform 2 namespace: protein def: "A nuclear receptor ROR-gamma that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P51450-2 or a 1:1 ortholog thereof." [] comment: Category=sequence. Requested by=CL. synonym: "RORC/iso:2" EXACT [] is_a: PR:000001902 ! nuclear receptor ROR-gamma [Term] id: PR:000003457 name: V(D)J recombination-activating protein 1 namespace: protein alt_id: PR:000013688 def: "A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "RAG-1" EXACT [] synonym: "RAG1" EXACT [] synonym: "RING finger protein 74" EXACT [] synonym: "RNF74" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003460 name: V(D)J recombination-activating protein 2 namespace: protein alt_id: PR:000013690 def: "A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "RAG-2" EXACT [] synonym: "RAG2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003463 name: eomesodermin namespace: protein alt_id: PR:000007101 def: "A T-brain transcription factor that is a translation product of the human EOMES gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "EOMES" EXACT [] synonym: "T-box brain protein 2" EXACT [] synonym: "T-brain-2" EXACT [] synonym: "TBR-2" EXACT [] synonym: "TBR2" RELATED [] is_a: PR:000003506 ! T-brain transcription factor [Term] id: PR:000003466 name: perforin-1 namespace: protein alt_id: PR:000013205 def: "A protein that is a translation product of the human PRF1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cytolysin" EXACT [] synonym: "lymphocyte pore-forming protein" EXACT [] synonym: "P1" RELATED [] synonym: "PFP" EXACT [] synonym: "PRF1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003469 name: early growth response protein 2 namespace: protein alt_id: PR:000006938 def: "A protein that is a translation product of the human EGR2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "AT591" EXACT [] synonym: "EGR-2" EXACT [] synonym: "EGR2" EXACT [] synonym: "Krox-20" RELATED [] synonym: "KROX20" RELATED [] synonym: "Zfp-25" RELATED [] synonym: "zinc finger protein Krox-20" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003499 name: granzyme B namespace: protein alt_id: PR:000003496 def: "A leukocyte granule-associated proteinase that is a translation product of the human GZMB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C11" EXACT [] synonym: "cathepsin G-like 1" EXACT [] synonym: "CGL1" RELATED [] synonym: "CSPB" RELATED [] synonym: "CTLA-1" BROAD [] synonym: "CTLA1" RELATED [] synonym: "CTSGL1" EXACT [] synonym: "cytotoxic T-lymphocyte proteinase 2" EXACT [] synonym: "fragmentin-2" BROAD [] synonym: "granzyme-2" EXACT [] synonym: "GRB" RELATED [] synonym: "GZMB" EXACT [] synonym: "HLP" RELATED [] synonym: "human lymphocyte protein" EXACT [] synonym: "lymphocyte protease" EXACT [] synonym: "SECT" EXACT [] synonym: "T-cell serine protease 1-3E" EXACT [] is_a: PR:000003505 ! leukocyte granule-associated proteinase [Term] id: PR:000003505 name: leukocyte granule-associated proteinase namespace: protein def: "A protein that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." [] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000003506 name: T-brain transcription factor namespace: protein def: "A protein that contains one copy of the T-box domain (PF00907) and it is involved in the anterior neural specification." [] comment: Category=family. synonym: "Eomes/Tbr1/Tbx21 family protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003516 name: lactosylceramide 4-alpha-galactosyltransferase namespace: protein def: "A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "A14GALT" RELATED [] synonym: "A4GALT" EXACT [] synonym: "A4GALT1" RELATED [] synonym: "alpha-1,4-galactosyltransferase" EXACT [] synonym: "alpha-1,4-N-acetylglucosaminyltransferase" BROAD [] synonym: "alpha4Gal-T1" EXACT [] synonym: "CD77 synthase" EXACT [] synonym: "Gb3 synthase" EXACT [] synonym: "globotriaosylceramide synthase" EXACT [] synonym: "P1/Pk synthase" EXACT [] synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005178 name: CD9 molecule namespace: protein def: "A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "5H9 antigen" EXACT [] synonym: "CD9" EXACT [] synonym: "CD9 antigen" EXACT [] synonym: "cell growth-inhibiting gene 2 protein" EXACT [] synonym: "leukocyte antigen MIC3" EXACT [] synonym: "MIC3" RELATED [] synonym: "motility-related protein" EXACT [] synonym: "MRP-1" EXACT [] synonym: "p24" RELATED [] synonym: "tetraspanin-29" EXACT [] synonym: "tspan-29" EXACT [] synonym: "TSPAN29" RELATED [] is_a: PR:000001403 ! tetraspanin [Term] id: PR:000005307 name: CCAAT/enhancer-binding protein alpha namespace: protein def: "A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C/EBP alpha" EXACT [] synonym: "CEBPA" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005310 name: CCAAT/enhancer-binding protein epsilon namespace: protein def: "A protein that is a translation product of the human CEBPE gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C/EBP epsilon" EXACT [] synonym: "CEBPE" EXACT [] synonym: "Gm294" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000006169 name: cell surface glycoprotein CD200 receptor 3 namespace: protein def: "A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD200 cell surface glycoprotein receptor-like 3" EXACT [] synonym: "CD200 cell surface glycoprotein receptor-like b" EXACT [] synonym: "CD200 receptor-like 3" EXACT [] synonym: "Cd200r3" EXACT [] synonym: "CD200RLb" EXACT [] synonym: "cell surface glycoprotein OX2 receptor 3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006172 name: CD209 molecule-like protein B namespace: protein def: "A protein that is a translation product of the mouse Cd209b gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Cd209b" EXACT [] synonym: "DC-SIGN-related protein 1" EXACT [] synonym: "DC-SIGNR1" EXACT [] synonym: "OtB7" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006611 name: DNA nucleotidylexotransferase namespace: protein def: "A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "DNTT" EXACT [] synonym: "TDT" EXACT [] synonym: "terminal addition enzyme" EXACT [] synonym: "terminal deoxynucleotidyltransferase" EXACT [] synonym: "terminal transferase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007152 name: eosinophil peroxidase namespace: protein def: "A protein that is a translation product of the human EPX gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "EPER" RELATED [] synonym: "EPO" BROAD [] synonym: "EPP" RELATED [] synonym: "EPX" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007431 name: high affinity immunoglobulin epsilon receptor subunit alpha namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Fc-epsilon RI-alpha" EXACT [] synonym: "FCE1A" RELATED [] synonym: "FCER1A" EXACT [] synonym: "FcERI" RELATED [] synonym: "IgE Fc receptor subunit alpha" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000007597 name: proto-oncogene c-Fos namespace: protein def: "A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cellular oncogene fos" EXACT [] synonym: "FOS" EXACT [] synonym: "G0/G1 switch regulatory protein 7" EXACT [] synonym: "G0S7" RELATED [] synonym: "proto-oncogene protein c-fos" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007857 name: erythroid transcription factor namespace: protein def: "A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Eryf1" EXACT [] synonym: "GATA-1" EXACT [] synonym: "GATA-binding factor 1" EXACT [] synonym: "GATA1" EXACT [] synonym: "GF-1" RELATED [] synonym: "GF1" RELATED [] synonym: "NF-E1 DNA-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007858 name: endothelial transcription factor GATA-2 namespace: protein def: "A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "GATA-binding protein 2" EXACT [] synonym: "GATA2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007939 name: glial fibrillary acidic protein namespace: protein def: "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "GFAP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008467 name: hemoglobin subunit zeta namespace: protein def: "A protein that is a translation product of the human HBZ gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "alpha-like embryonic globin chain x" EXACT [] synonym: "Hba-x" RELATED [] synonym: "HBAZ" EXACT [] synonym: "HBZ" EXACT [] synonym: "Hbz1" RELATED [] synonym: "HBZ2" RELATED [] synonym: "hemoglobin zeta chain" EXACT [] synonym: "zeta-globin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008857 name: hemoglobin subunit beta-1 namespace: protein def: "A protein that is a translation product of the mouse Hbb-b1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "beta-1-globin" EXACT [] synonym: "Hbb-b1" EXACT [] synonym: "hemoglobin beta-1 chain" EXACT [] synonym: "hemoglobin beta-major chain" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008982 name: interleukin-17 receptor B namespace: protein def: "A protein that is a translation product of the human IL17RB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CRL4" RELATED [] synonym: "cytokine receptor-like 4" EXACT [] synonym: "EVI27" RELATED [] synonym: "IL-17 receptor B" EXACT [] synonym: "IL-17 receptor homolog 1" EXACT [] synonym: "IL-17B receptor" EXACT [] synonym: "IL-17ER" EXACT [] synonym: "IL-17RB" EXACT [] synonym: "IL-17Rh1" EXACT [] synonym: "IL17BR" RELATED [] synonym: "IL17RB" EXACT [] synonym: "IL17Rh1" EXACT [] synonym: "interleukin-17B receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008994 name: interleukin-1 receptor-like 1 namespace: protein def: "A protein that is a translation product of the human IL1RL1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "DER4" RELATED [] synonym: "IL1RL1" EXACT [] synonym: "Ly84" RELATED [] synonym: "lymphocyte antigen 84" EXACT [] synonym: "protein ST2" EXACT [] synonym: "protein T1" EXACT [] synonym: "ST2" RELATED [] synonym: "Ste2" RELATED [] synonym: "T1" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000009127 name: integrin alpha-IIb namespace: protein def: "An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD41" EXACT [] synonym: "GP2B" RELATED [] synonym: "GPalpha IIb" EXACT [] synonym: "GPIIb" EXACT [] synonym: "ITGA2B" EXACT [] synonym: "ITGAB" RELATED [] synonym: "platelet membrane glycoprotein IIb" EXACT [] is_a: PR:000025797 ! integrin alpha lacking A domain [Term] id: PR:000009129 name: integrin alpha-4 namespace: protein def: "An integrin alpha lacking A domain that is a translation product of the human ITGA4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD49 antigen-like family member D" EXACT [] synonym: "CD49d" EXACT [] synonym: "integrin alpha-IV" EXACT [] synonym: "ITGA4" EXACT [] synonym: "LPAM subunit alpha" EXACT [] synonym: "lymphocyte Peyer patch adhesion molecules subunit alpha" EXACT [] synonym: "VLA-4 subunit alpha" EXACT [] is_a: PR:000025797 ! integrin alpha lacking A domain [Term] id: PR:000009143 name: integrin beta-7 namespace: protein def: "An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Gut homing receptor beta subunit" EXACT [] synonym: "integrin beta-P" EXACT [] synonym: "ITGB7" EXACT [] synonym: "M290 IEL antigen" EXACT [] is_a: PR:000001861 ! integrin beta [Term] id: PR:000009616 name: T-cell surface glycoprotein YE1/48 namespace: protein def: "A protein that is a translation product of the mouse Klra1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Klra1" EXACT [] synonym: "Ly-49" RELATED [] synonym: "ly-49a" EXACT [] synonym: "Ly49" RELATED [] synonym: "Ly49A" RELATED [] synonym: "lymphocyte antigen 49a" EXACT [] synonym: "T lymphocyte antigen A1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009618 name: killer cell lectin-like receptor 3 namespace: protein def: "A protein that is a translation product of the mouse Klra3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "5E6" EXACT [] synonym: "Klra3" EXACT [] synonym: "ly-49c" EXACT [] synonym: "Ly49C" RELATED [] synonym: "lymphocyte antigen 49c" EXACT [] synonym: "T-cell surface glycoprotein Ly-49C" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009619 name: killer cell lectin-like receptor 4 namespace: protein def: "A protein that is a translation product of the mouse Klra4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Klra4" EXACT [] synonym: "ly-49d" EXACT [] synonym: "Ly49-d" RELATED [] synonym: "Ly49d" RELATED [] synonym: "lymphocyte antigen 49d" EXACT [] synonym: "T-cell surface glycoprotein Ly-49D" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009623 name: killer cell lectin-like receptor 8 namespace: protein def: "A protein that is a translation product of the mouse Klra8 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Klra8" EXACT [] synonym: "ly-49h" EXACT [] synonym: "Ly49-h" RELATED [] synonym: "Ly49H" RELATED [] synonym: "lymphocyte antigen 49h" EXACT [] synonym: "T-cell surface glycoprotein Ly-49H" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009725 name: neutrophil gelatinase-associated lipocalin namespace: protein def: "A protein that is a translation product of the human LCN2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "25 kDa alpha-2-microglobulin-related subunit of MMP-9" EXACT [] synonym: "HNL" RELATED [] synonym: "LCN2" EXACT [] synonym: "lipocalin-2" EXACT [] synonym: "NGAL" EXACT [] synonym: "oncogene 24p3" EXACT [] synonym: "p25" RELATED [] synonym: "SV-40-induced 24P3 protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009766 name: galectin-1 namespace: protein def: "A protein that is a translation product of the human LGALS1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "14 kDa laminin-binding protein" EXACT [] synonym: "14 kDa lectin" EXACT [] synonym: "beta-galactoside-binding lectin L-14-I" EXACT [] synonym: "gal-1" EXACT [] synonym: "galaptin" EXACT [] synonym: "Gbp" RELATED [] synonym: "HBL" EXACT [] synonym: "HLBP14" EXACT [] synonym: "HPL" EXACT [] synonym: "lactose-binding lectin 1" EXACT [] synonym: "lectin galactoside-binding soluble 1" EXACT [] synonym: "LGALS1" EXACT [] synonym: "putative MAPK-activating protein PM12" EXACT [] synonym: "S-Lac lectin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009978 name: lactotransferrin namespace: protein def: "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "lactoferrin" EXACT [] synonym: "LF" RELATED [] synonym: "LTF" EXACT [] synonym: "talalactoferrin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010329 name: tyrosine-protein kinase Mer namespace: protein def: "A protein that is a translation product of the human MERTK gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "MER" RELATED [] synonym: "MERTK" EXACT [] synonym: "proto-oncogene c-Mer" EXACT [] synonym: "proto-oncogene tyrosine-protein kinase MER" EXACT [] synonym: "receptor tyrosine kinase MerTK" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010543 name: myeloperoxidase namespace: protein def: "A protein that is a translation product of the human MPO gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "MPO" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010799 name: myb proto-oncogene protein namespace: protein def: "A protein that is a translation product of the human MYB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "MYB" EXACT [] synonym: "proto-oncogene c-Myb" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011178 name: nuclear factor NF-kappa-B p100 subunit namespace: protein def: "A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "DNA-binding factor KBF2" EXACT [] synonym: "H2TF1" EXACT [] synonym: "lymphocyte translocation chromosome 10 protein" EXACT [] synonym: "lyt10" EXACT [] synonym: "NFKB2" EXACT [] synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2" EXACT [] synonym: "oncogene Lyt-10" EXACT [] is_a: PR:000001753 ! transcription factor NF-kappa-B subunit [Term] id: PR:000013206 name: bone marrow proteoglycan namespace: protein def: "A protein that is a translation product of the human PRG2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. synonym: "BMPG" EXACT [] synonym: "MBP" RELATED [] synonym: "Mbp-1" RELATED [] synonym: "PRG2" EXACT [] synonym: "proteoglycan 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000014046 name: non-secretory ribonuclease namespace: protein def: "A protein that is a translation product of the human RNASE2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Ear4" RELATED [] synonym: "EDN" RELATED [] synonym: "eosinophil cationic-type ribonuclease 4" EXACT [] synonym: "eosinophil-derived neurotoxin" EXACT [] synonym: "MR-4" EXACT [] synonym: "ribonuclease 2" EXACT [] synonym: "ribonuclease US" EXACT [] synonym: "RNase 2" EXACT [] synonym: "RNase UpI-2" EXACT [] synonym: "RNASE2" EXACT [] synonym: "RNS2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000014047 name: eosinophil cationic protein namespace: protein def: "A protein that is a translation product of the human RNASE3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ECP" EXACT [] synonym: "ribonuclease 3" RELATED [] synonym: "RNase 3" EXACT [] synonym: "RNASE3" EXACT [] synonym: "RNS3" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000014362 name: runt-related transcription factor 1 namespace: protein def: "A protein that is a translation product of the human RUNX1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "acute myeloid leukemia 1 protein" EXACT [] synonym: "AML1" RELATED [] synonym: "CBF-alpha-2" EXACT [] synonym: "CBFA2" RELATED [] synonym: "core-binding factor subunit alpha-2" EXACT [] synonym: "oncogene AML-1" EXACT [] synonym: "PEA2-alpha B" EXACT [] synonym: "PEBP2-alpha B" EXACT [] synonym: "Pebp2ab" RELATED [] synonym: "polyomavirus enhancer-binding protein 2 alpha B subunit" EXACT [] synonym: "RUNX1" EXACT [] synonym: "SL3-3 enhancer factor 1 alpha B subunit" EXACT [] synonym: "SL3/AKV core-binding factor alpha B subunit" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016043 name: T-cell acute lymphocytic leukemia protein 1 namespace: protein def: "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "bHLHa17" EXACT [] synonym: "class A basic helix-loop-helix protein 17" EXACT [] synonym: "SCL" RELATED [] synonym: "stem cell protein" EXACT [] synonym: "T-cell leukemia/lymphoma protein 5" EXACT [] synonym: "TAL-1" EXACT [] synonym: "TAL1" EXACT [] synonym: "TCL5" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000016401 name: transmembrane emp24 domain-containing protein 1 namespace: protein def: "A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "IL1RL1L" RELATED [] synonym: "IL1RL1LG" RELATED [] synonym: "interleukin-1 receptor-like 1 ligand" EXACT [] synonym: "putative T1/ST2 receptor-binding protein" EXACT [] synonym: "TMED1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000018263 name: amino acid chain namespace: protein def: "A molecular entity that is a polymer of amino acids linked by peptide bonds." [] synonym: "peptide" NARROW [] synonym: "polypeptide" NARROW [] [Term] id: PR:000018264 name: proteolytic cleavage product namespace: protein def: "An amino acid chain produced as the result of peptide bond cleavage of a longer amino acid chain." [] synonym: "peptide" NARROW [] synonym: "polypeptide" NARROW [] is_a: PR:000018263 ! amino acid chain [Term] id: PR:000018311 name: integrin alpha-E proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from integrin alpha-E." [] comment: Category=modification. synonym: "ITGAE/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018335 name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." [] comment: Category=modification. synonym: "CD8A/SigPep-" EXACT [] is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: PR:000018337 name: T-cell surface glycoprotein CD8 beta chain, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed." [] comment: Category=modification. synonym: "CD8B1/SigPep-" EXACT [] is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain [Term] id: PR:000018381 name: CD48 molecule proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from CD48 molecule." [] comment: Category=modification. synonym: "CD48/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018390 name: L-selectin proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from L-selectin." [] comment: Category=modification. synonym: "SELL/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018406 name: carcinoembryonic antigen-related cell adhesion molecule 8 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from carcinoembryonic antigen-related cell adhesion molecule 8." [] comment: Category=modification. synonym: "CEACAM8/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018481 name: epithelial cadherin proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from epithelial cadherin." [] comment: Category=modification. synonym: "CDH1/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018524 name: 5'-nucleotidase proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from 5'-nucleotidase." [] comment: Category=modification. synonym: "NT5E/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018546 name: Thy-1 membrane glycoprotein proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from Thy-1 membrane glycoprotein." [] comment: Category=modification. synonym: "THY1/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018547 name: cathepsin K proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from cathepsin K." [] comment: Category=modification. synonym: "CTSK/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018568 name: low affinity immunoglobulin epsilon Fc receptor proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from low affinity immunoglobulin epsilon Fc receptor." [] comment: Category=modification. synonym: "FCER2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018575 name: CD14 molecule proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from CD14 molecule." [] comment: Category=modification. synonym: "CD14/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018591 name: platelet glycoprotein Ib alpha chain proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from platelet glycoprotein Ib alpha chain." [] comment: Category=modification. synonym: "GP1BA/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018594 name: scavenger receptor cysteine-rich type 1 protein M130 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from scavenger receptor cysteine-rich type 1 protein M130." [] comment: Category=modification. synonym: "CD163/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018603 name: transferrin receptor protein 1 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from transferrin receptor protein 1." [] comment: Category=modification. synonym: "TFRC/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018606 name: tumor necrosis factor ligand superfamily member 5 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from tumor necrosis factor ligand superfamily member 5." [] comment: Category=modification. synonym: "CD40LG/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000019802 name: eosinophil peroxidase proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from eosinophil peroxidase." [] comment: Category=modification. synonym: "EPX/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020329 name: integrin alpha-IIb proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from integrin alpha-IIb." [] comment: Category=modification. synonym: "ITGA2B/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020497 name: lactotransferrin proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from lactotransferrin." [] comment: Category=modification. synonym: "LTF/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020631 name: myeloperoxidase proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from myeloperoxidase." [] comment: Category=modification. synonym: "MPO/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020735 name: nuclear factor NF-kappa-B p100 subunit proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from nuclear factor NF-kappa-B p100 subunit." [] comment: Category=modification. synonym: "NFKB2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000021081 name: bone marrow proteoglycan, signal peptide removed form namespace: protein def: "A bone marrow proteoglycan that has had the signal peptide removed." [] comment: Category=modification. synonym: "PRG2/SigPep-" EXACT [] is_a: PR:000013206 ! bone marrow proteoglycan [Term] id: PR:000021082 name: bone marrow proteoglycan proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from bone marrow proteoglycan." [] comment: Category=modification. synonym: "PRG2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000022003 name: bone marrow proteoglycan isoform 1 namespace: protein def: "A bone marrow proteoglycan that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P13727-1 or a 1:1 ortholog thereof." [] comment: Category=sequence. synonym: "PRG2/iso:1" EXACT [] is_a: PR:000013206 ! bone marrow proteoglycan [Term] id: PR:000022006 name: eosinophil granule major basic protein namespace: protein def: "A bone marrow proteoglycan proteolytic cleavage product that derives from bone marrow proteoglycan isoform 1, signal peptide removed form that has had the acidic propeptide removed." [] comment: Category=modification. Requested by=CL. is_a: PR:000021082 ! bone marrow proteoglycan proteolytic cleavage product [Term] id: PR:000025402 name: T cell receptor co-receptor CD8 namespace: protein def: "A protein complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." [] comment: Category=complex. Requested by=CL. synonym: "CD8alphabeta" EXACT [] synonym: "TCR co-receptor CD8" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: PR:000025403 name: T-cell surface glycoprotein CD8 alpha chain isoform 1 namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." [] comment: Category=sequence. Requested by=CL. synonym: "CD8A/iso:1" EXACT [] synonym: "mCD8alpha" EXACT [] is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: PR:000025405 name: T-cell surface glycoprotein CD8 beta chain isoform 1 namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof." [] comment: Category=sequence. synonym: "CD8B1/iso:1" EXACT [] synonym: "CD8beta isoform M-1" EXACT [] is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain [Term] id: PR:000025406 name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." [] comment: Category=modification. synonym: "CD8A/iso:1/SigPep-" EXACT [] is_a: PR:000018335 ! T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form is_a: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 [Term] id: PR:000025407 name: T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form." [] comment: Category=modification. synonym: "CD8B1/iso:1/SigPep-" EXACT [] is_a: PR:000018337 ! T-cell surface glycoprotein CD8 beta chain, signal peptide removed form is_a: PR:000025405 ! T-cell surface glycoprotein CD8 beta chain isoform 1 [Term] id: PR:000025408 name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that has been post-translationally modified to include at least one glycosylated residue." [] comment: Category=modification. synonym: "CD8A/iso:1/SigPep-/GlycoRes+" EXACT [] is_a: PR:000025406 ! T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form is_a: PR:000037069 ! glycoprotein [Term] id: PR:000025409 name: T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed glycosylated form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that has been post-translationally modified to include at least one glycosylated residue." [] comment: Category=modification. synonym: "CD8B1/iso:1/SigPep-/GlycoRes+" EXACT [] is_a: PR:000025407 ! T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form is_a: PR:000037069 ! glycoprotein [Term] id: PR:000025455 name: CD2 molecule proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from CD2 molecule." [] comment: Category=modification. synonym: "CD2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000025466 name: bone marrow proteoglycan isoform 1, signal peptide removed form namespace: protein def: "A bone marrow proteoglycan isoform 1 that has had the signal peptide removed." [] comment: Category=modification. synonym: "PRG2/iso:1/SigPep-" EXACT [] is_a: PR:000021081 ! bone marrow proteoglycan, signal peptide removed form is_a: PR:000022003 ! bone marrow proteoglycan isoform 1 [Term] id: PR:000025796 name: integrin alpha namespace: protein def: "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." [] comment: Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. is_a: PR:000000001 ! protein [Term] id: PR:000025797 name: integrin alpha lacking A domain namespace: protein def: "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." [] comment: Category=family. xref: PIRSF:PIRSF005666 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000037069 name: glycoprotein namespace: protein def: "A protein that contains at least one glycosylated residue." [] comment: Category=modification. synonym: "glycated protein" EXACT [] synonym: "glycosylated protein" EXACT [] synonym: "Prot/GlycoRes+" EXACT [] is_a: PR:000000001 ! protein [Term] id: UBERON:0000002 name: uterine cervix def: "Lower, narrow portion of the uterus where it joins with the top end of the vagina." [] synonym: "canalis cervicis uteri" EXACT [] synonym: "caudal segment of uterus" EXACT [] synonym: "cervical canal" RELATED [] synonym: "cervical canal of uterus" EXACT [] synonym: "cervix" BROAD [] synonym: "cervix of uterus" RELATED [] synonym: "cervix uteri" EXACT [] synonym: "neck of uterus" EXACT [] synonym: "uterine cervix" EXACT [] is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0000995 ! uterus [Term] id: UBERON:0000004 name: olfactory apparatus synonym: "nasal sac" EXACT [] synonym: "nasus" RELATED [] synonym: "nose" EXACT [] synonym: "peripheral olfactory organ" EXACT [] synonym: "proboscis" RELATED [] is_a: UBERON:0002268 ! olfactory organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0003050 ! olfactory placode relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0004089 ! midface [Term] id: UBERON:0000006 name: islet of Langerhans def: "Regions of the pancreas that contain its endocrine (i.e., hormone-producing) cells." [] synonym: "island of Langerhans" RELATED [] synonym: "island of pancreas" RELATED [] synonym: "islets of langerhans" RELATED [] synonym: "pancreatic insula" EXACT [] synonym: "pancreatic islet" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0000016 ! endocrine pancreas [Term] id: UBERON:0000007 name: pituitary gland def: "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." [] synonym: "glandula pituitaria" RELATED [] synonym: "Hp" BROAD [] synonym: "hypophysis" RELATED [] synonym: "hypophysis cerebri" RELATED [] synonym: "pituitary" EXACT [] synonym: "pituitary body" EXACT [] synonym: "posterior inferotemporal cortex" RELATED [] is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010133 ! neuroendocrine gland is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0000924 ! ectoderm relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0000009 name: submucosa def: "A layer of dense irregular connective tissue in the gastrointestinal tract that supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle (fibers running circularly within layer of longitudinal muscle). [WP,unvetted]." [] synonym: "organ submucosa" EXACT [] synonym: "region of submucosa" EXACT [] synonym: "submucosa of organ" EXACT [] synonym: "submucosa of region of organ" EXACT [] synonym: "submucous layer" RELATED [] synonym: "tela submucosa" RELATED [] synonym: "tunica submucosa" RELATED [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0000010 name: peripheral nervous system def: "Nervous structures including ganglia outside of the central nervous system. Divided into somatic nervous system and autonomic nervous system" [] synonym: "lateral part of the basal amygdalar nucleus" RELATED [] synonym: "lateral part of the basolateral nucleus" RELATED [] synonym: "nucleus amygdalae basalis, pars lateralis" RELATED [] synonym: "nucleus amygdaloideus basalis, pars lateralis magnocellularis" RELATED [] synonym: "nucleus basalis lateralis amygdalae" RELATED [] synonym: "pars peripherica; systema nervosum periphericum" RELATED [] synonym: "PNS" RELATED [] is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0000012 name: somatic nervous system def: "Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors." [] synonym: "PNS - somatic" EXACT [] synonym: "somatic nervous system, somatic division" EXACT [] synonym: "somatic peripheral nervous system" EXACT [] is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0000013 name: sympathetic nervous system def: "The Sympathetic Nervous System (SNS) is a branch of the autonomic nervous system along with the enteric nervous system and parasympathetic nervous system. It is always active at a basal level (called sympathetic tone) and becomes more active during times of stress. Its actions during the stress response comprise the fight-or-flight response [Wikipedia]. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." [] synonym: "pars sympathica divisionis autonomici systematis nervosi" EXACT [] synonym: "pars sympathica divisionis autonomici systematis nervosi" RELATED [] synonym: "sympathetic nervous system" EXACT [] synonym: "sympathetic part of autonomic division of nervous system" EXACT [] is_a: UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0000016 name: endocrine pancreas def: "The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin[GO]." [] synonym: "endocrine pancreas" EXACT [] synonym: "endocrine part of pancreas" RELATED [] synonym: "islets of Langerhans part of pancreas" RELATED [] synonym: "pars endocrina pancreatis" EXACT [] is_a: UBERON:0002075 ! viscus is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0003923 ! dorsal pancreatic bud relationship: part_of UBERON:0001264 ! pancreas [Term] id: UBERON:0000017 name: exocrine pancreas def: "The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion." [] synonym: "exocrine pancreas" EXACT [] synonym: "exocrine part of pancreas" RELATED [] synonym: "pars exocrina pancreatis" EXACT [] is_a: UBERON:0002075 ! viscus is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0003924 ! ventral pancreatic bud relationship: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0000018 name: compound eye def: "A light sensing organ composed of ommatidia" [] synonym: "adult compound eye" RELATED [] synonym: "Facettenauge" RELATED [] synonym: "insect eye" RELATED [] synonym: "Komplexauge" RELATED [] synonym: "zusammengesetztes Auge" RELATED [] is_a: UBERON:0000970 ! eye [Term] id: UBERON:0000019 name: camera-type eye def: "The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field[GO]. The eye contains the following parts (when they are present in the organism): the eyeball (eye proper), the lacrimal apparatus, the conjuctival, the eyelid." [] synonym: "camera-type eye plus associated structures" RELATED [] synonym: "eye" BROAD [] synonym: "eyes" RELATED [] synonym: "orbital part of face" EXACT [] synonym: "orbital region" RELATED [] synonym: "regio orbitalis" EXACT [] synonym: "vertebrate eye" NARROW [] is_a: UBERON:0000047 ! simple eye is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003072 ! optic cup relationship: part_of UBERON:0004088 ! ocular region [Term] id: UBERON:0000020 name: sense organ def: "An organ that is capable of detection of chemical stimulus involved in sensory perception of smell." [] synonym: "organ of sense organ system" EXACT [] synonym: "organ of sensory organ system" EXACT [] synonym: "organ of sensory system" EXACT [] synonym: "sense organ system organ" EXACT [] synonym: "sensillum" NARROW [] synonym: "sensor" RELATED [] synonym: "sensory organ" EXACT [] synonym: "sensory organ system organ" EXACT [] synonym: "sensory system organ" EXACT [] synonym: "Sinnesorgan" RELATED [] is_a: UBERON:0000062 ! organ relationship: part_of UBERON:0001032 ! sensory system [Term] id: UBERON:0000025 name: tube def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." [] synonym: "anatomical tube" EXACT [] synonym: "duct" NARROW [] is_a: UBERON:0004111 ! anatomical conduit [Term] id: UBERON:0000029 name: lymph node def: "Oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph nodes are garrisons of B, T, and other immune cells. Lymph nodes are found all through the body, and act as filters or traps for foreign particles. They contain white blood cells that use oxygen to process. Thus they are important in the proper functioning of the immune system. The lymph node is surrounded by a fibrous capsule, and inside the lymph node the fibrous capsule extends to form trabeculae. The substance of the lymph node is divided into the outer cortex and the inner medulla surrounded by the former all around except for at the hilum, where the medulla comes in direct contact with the surface. Thin reticular fibers, elastin and reticular fibers form a supporting meshwork called reticular network (RN) inside the node, within which the white blood cells (WBCs), most prominently, lymphocytes are tightly packed as follicles in the cortex. Elsewhere, there are only occasional WBCs. The RN provides not just the structural support, but also provide surface for adhesion of the dendritic cells, macrophages and lymphocytes. It allows for exchange of material with blood through the high endothelial venules and provides the growth and regulatory factors necessary for activation and maturation of immune cells[WP]." [] synonym: "lymph gland" RELATED [] synonym: "nodus lymphaticus" RELATED [] is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0002465 ! lymphoid system [Term] id: UBERON:0000030 name: lamina propria def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." [] synonym: "lamina propria mucosa" EXACT [] synonym: "lamina propria mucosae" EXACT [] synonym: "tunica propria" RELATED [] is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0000344 ! mucosa [Term] id: UBERON:0000031 name: lamina propria of trachea def: "A lamina propria that is part of a respiratory airway." [] synonym: "lamina propria mucosa of trachea" EXACT [] synonym: "lamina propria mucosa of windpipe" EXACT [] synonym: "lamina propria mucosae of trachea" EXACT [] synonym: "lamina propria mucosae of windpipe" EXACT [] synonym: "lamina propria of windpipe" EXACT [] synonym: "trachea lamina propria" EXACT [] synonym: "trachea lamina propria mucosa" EXACT [] synonym: "trachea lamina propria mucosae" EXACT [] synonym: "tracheal lamina propria" EXACT [] synonym: "windpipe lamina propria" EXACT [] synonym: "windpipe lamina propria mucosa" EXACT [] synonym: "windpipe lamina propria mucosae" EXACT [] is_a: UBERON:0004779 ! respiratory system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0001005 ! respiratory airway relationship: part_of UBERON:0000379 ! tracheal mucosa relationship: part_of UBERON:0001005 ! respiratory airway [Term] id: UBERON:0000033 name: head def: "The head is the anterior-most division of the body [GO]." [] synonym: "adult head" NARROW [] synonym: "cephalic area" RELATED [] synonym: "head (volume)" EXACT [] is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: part_of UBERON:0000153 ! anterior region of body relationship: part_of UBERON:0007811 ! craniocervical region [Term] id: UBERON:0000042 name: serous membrane def: "multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." [] synonym: "serosa" RELATED [] synonym: "tunica serosa" EXACT [] synonym: "wall of serous sac" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004457 ! cavity lining relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000060 ! anatomical wall [Term] id: UBERON:0000043 name: tendon def: "Dense regular connective tissue that connects muscle to bone[VSAO]." [] synonym: "sinew" RELATED [] synonym: "tendo" RELATED [] is_a: UBERON:0007846 ! dense regular connective tissue relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] id: UBERON:0000044 name: dorsal root ganglion def: "ganglion on the dorsal root of each spinal nerve that is one of a series of ganglia lodging cell bodies of sensory neurons[BTO]. Trunk ganglion which is located adjacent to the spine on a dorsal root and contains the cell bodies of afferent sensory nerves[..]. one on the posterior root of each spinal nerve, composed of unipolar nerve cell bodies of the sensory neurons of the nerve[TFD]." [] synonym: "dorsal root ganglia" RELATED [] synonym: "dorsal root ganglion" EXACT [] synonym: "DRG" RELATED [] synonym: "ganglion of dorsal root" EXACT [] synonym: "ganglion sensorium nervi spinalis" RELATED [] synonym: "ganglion spinale" RELATED [] synonym: "ganglion spinalis" EXACT [] synonym: "spinal ganglion" EXACT [] is_a: UBERON:0001800 ! sensory ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0002261 ! dorsal root of spinal cord relationship: develops_from UBERON:0003083 ! trunk neural crest relationship: part_of UBERON:0002261 ! dorsal root of spinal cord [Term] id: UBERON:0000045 name: ganglion def: "A biological tissue mass, most commonly a mass of nerve cell bodies." [] synonym: "ganglia" RELATED [] synonym: "neural ganglion" RELATED [] is_a: UBERON:0003714 ! neural tissue relationship: develops_from UBERON:0003869 ! presumptive ganglion relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0000047 name: simple eye def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." [] is_a: UBERON:0000970 ! eye [Term] id: UBERON:0000054 name: macula def: "Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified]." [] synonym: "acoustic macula" RELATED [] synonym: "acoustic maculae" RELATED [] synonym: "macula" EXACT [] synonym: "maculae" EXACT [] synonym: "sensory macula" EXACT [] synonym: "sensory patch" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001846 ! internal ear [Term] id: UBERON:0000055 name: vessel def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [] is_a: UBERON:0004111 ! anatomical conduit [Term] id: UBERON:0000056 name: ureter def: "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. In humans, organ with organ cavity which connects the renal sinus to the urinary bladder. Examples: the right and the left ureters." [] synonym: "metanephric duct" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region organ is_a: UBERON:0006555 ! excretory tube relationship: develops_from UBERON:0005081 ! ureter ureteric bud relationship: part_of UBERON:0002355 ! pelvis relationship: part_of UBERON:0011143 ! upper urinary tract [Term] id: UBERON:0000057 name: urethra def: "A tube which connects the urinary bladder to the outside of the body. In males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter and emerges above the vaginal opening. The external urethral sphincter is a striated muscle that allows voluntary control over urination." [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0000164 ! primitive urogenital sinus relationship: part_of UBERON:0001556 ! lower urinary tract [Term] id: UBERON:0000058 name: duct def: "A tubular structure that transports or secretes substances." [] synonym: "anatomical duct" EXACT [] synonym: "exocrine duct" NARROW [] synonym: "exocrine gland duct" NARROW [] is_a: UBERON:0000025 ! tube [Term] id: UBERON:0000059 name: large intestine def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [] synonym: "intestinum crassum" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system organ relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0004907 ! lower digestive tract [Term] id: UBERON:0000060 name: anatomical wall def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." [] synonym: "organ wall" RELATED [] synonym: "wall" BROAD [] synonym: "wall of organ" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000061 name: anatomical structure def: "Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome." [] synonym: "biological structure" EXACT [] is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0000062 name: organ def: "Anatomical structure that performs a specific function or group of functions [WP]. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions[GO]." [] synonym: "anatomical unit" RELATED [] synonym: "body organ" RELATED [] synonym: "element" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0000467 ! anatomical system [Term] id: UBERON:0000063 name: organ segment def: "Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball[FMA]." [] synonym: "organ region with fixed fiat boundary" EXACT [] synonym: "segment of organ" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000064 name: organ part def: "anatomical structure which has as its direct parts two or more types of tissue and is continuous with one or more anatomical structures likewise constituted by two or more portions of tissues distinct from those of their complement. Examples: osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior right side of heart, interventricular branch of left coronary artery, right atrium, mitral valve, head of pancreas[FMA]." [] synonym: "cardinal organ part" EXACT [] synonym: "regional part of organ" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0000062 ! organ [Term] id: UBERON:0000065 name: respiratory tract def: "anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts" [] is_a: UBERON:0001005 ! respiratory airway is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0007026 ! primitive gut relationship: develops_from UBERON:0008947 ! respiratory primordium relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0000072 name: segment of respiratory tract def: "An organ segment that is part of a respiratory tract [Automatically generated definition]." [] synonym: "respiratory tract" RELATED [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000063 ! organ segment intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract [Term] id: UBERON:0000073 name: regional part of nervous system def: "An anatomical structure that is part of a nervous system [Automatically generated definition]." [] synonym: "part of nervous system" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0000074 name: renal glomerulus def: "A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO]." [] synonym: "glomerular capillary tuft" RELATED [] synonym: "glomerular tuft" RELATED [] synonym: "glomerulus" BROAD [] synonym: "glomerulus renis" RELATED [] synonym: "malphigian glomerulus" RELATED [] synonym: "renal corpuscle" RELATED [] synonym: "renal glomeruli" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0005749 ! glomerular tuft relationship: part_of UBERON:0001229 ! renal corpuscle [Term] id: UBERON:0000075 name: subdivision of skeletal system def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." [] synonym: "skeletal system part" RELATED [] synonym: "skeletal system subdivision" EXACT [] is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0000076 name: external ectoderm def: "the surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." [] synonym: "surface (external) ectoderm" EXACT [] synonym: "surface ectoderm" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0000924 ! ectoderm [Term] id: UBERON:0000077 name: mixed endoderm/mesoderm-derived structure def: "An anatomical structure that develops from the endoderm and the mesoderm." [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0000078 name: mixed ectoderm/mesoderm/endoderm-derived structure def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0000079 name: male reproductive system def: "the organs associated with producing offspring in the gender that produces spermatozoa." [] synonym: "genitalia of male organism" EXACT [] synonym: "male genital organ" RELATED [] synonym: "male genital system" EXACT [] synonym: "male genitalia" EXACT [] synonym: "male genitals" EXACT [] synonym: "male organism genitalia" EXACT [] synonym: "male organism reproductive system" EXACT [] synonym: "male reproductive tract" RELATED [] synonym: "reproductive system of male organism" EXACT [] synonym: "systema genitale masculinum" RELATED [] is_a: UBERON:0000990 ! reproductive system is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000990 ! reproductive system intersection_of: part_of UBERON:0003101 ! male organism relationship: part_of UBERON:0003101 ! male organism [Term] id: UBERON:0000080 name: mesonephros def: "In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney[GO]. One of three excretory organs that develop in vertebrates. It serves as the main excretory organ of aquatic vertebrates and as a temporary kidney in higher vertebrates. composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo." [] synonym: "corpus Wolffi" RELATED [] synonym: "mesonephric kidney" EXACT [] synonym: "mesonephroi" EXACT [] synonym: "middle kidney" RELATED [] synonym: "opisthonephros" RELATED [] synonym: "opisto nephros" RELATED [] synonym: "opistonephros" RELATED [] synonym: "Wolffian body" EXACT [] is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0002120 ! pronephros [Term] id: UBERON:0000081 name: metanephros def: "In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO]. During the fifth week of gestation, the mesonephric duct develops an outpouching, the ureteric bud, near its attachment to the cloaca. This bud, also called the metanephrogenic diverticulum, grows posteriorly and towards the head of the embryo. The elongated stalk of the ureteric bud, the metanephric duct, later forms the ureter. As the cranial end of the bud extends into the intermediate mesoderm, it undergoes a series of branchings to form the collecting duct system of the kidney. It also forms the major and minor calyces and the renal pelvis." [] synonym: "definite kidney" RELATED [] synonym: "definitive kidney" RELATED [] synonym: "hind kidney" RELATED [] synonym: "metanephric kidney" RELATED [] synonym: "metanephron" EXACT [] is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: develops_from UBERON:0005080 ! metanephric ureteric bud relationship: develops_from UBERON:0005753 ! caudal part of nephrogenic cord [Term] id: UBERON:0000083 name: mesonephric tubule def: "A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]." [] synonym: "renal tubules" RELATED [] synonym: "tubuli mesonephrici" RELATED [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005103 ! mesonephric epithelium is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0003914 ! epithelial tube intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0000084 name: ureteric bud def: "An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP]" [] synonym: "diverticulum" RELATED [] synonym: "diverticulum metanephricum" RELATED [] synonym: "gemma ureterica" RELATED [] synonym: "metanephric bud" RELATED [] synonym: "metanephric diverticulum" RELATED [] synonym: "ureteric ampulla" RELATED [] synonym: "ureteric diverticulum" RELATED [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0007499 ! epithelial sac relationship: develops_from UBERON:0003074 ! mesonephric duct relationship: part_of UBERON:0003074 ! mesonephric duct [Term] id: UBERON:0000085 name: morula def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [] synonym: "morula (2-16 cells)" RELATED [] is_a: UBERON:0000922 ! embryo relationship: part_of UBERON:0004716 ! conceptus [Term] id: UBERON:0000087 name: inner cell mass def: "Mass of cells inside the primordial embryo that will eventually give rise to the definitive structures of the fetus. This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred. The ICM lies within the blastocoele (more correctly termed 'blastocyst cavity', as it is not strictly homologous to the blastocoele of anamniote vertebrates) and is entirely surrounded by the single layer of cells called trophoblast." [] synonym: "embryoblast" RELATED [] synonym: "embryoblastus; massa cellularis interna; pluriblastus senior" RELATED [] synonym: "ICM" RELATED [] synonym: "pluriblast" RELATED [] is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000085 ! morula relationship: develops_from UBERON:0000358 ! blastocyst relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0000091 name: bilaminar disc def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." [] synonym: "bilaminar disk" RELATED [] synonym: "bilaminary embryonic disc" EXACT [] synonym: "bilaminary germ disc" EXACT [] synonym: "embryonic disc" BROAD [] synonym: "embryonic shield" BROAD [] synonym: "germinal disc" BROAD [] synonym: "germinal disk" BROAD [] is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000087 ! inner cell mass [Term] id: UBERON:0000094 name: membrane organ def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]" [] synonym: "membrane of organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0000095 name: cardiac neural crest def: "portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]" [] synonym: "cardiac neural crest complex" RELATED [] synonym: "complexus cristae neuralis cardiacus" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0002342 ! neural crest [Term] id: UBERON:0000102 name: lung vasculature def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." [] synonym: "lung vascular network" EXACT [] synonym: "pulmonary vasculature" EXACT [] synonym: "vascular network of lung" EXACT [] synonym: "vasculature of lung" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0000114 name: lung connective tissue def: "A portion of connective tissue that is part of a lung [Automatically generated definition]." [] synonym: "connective tissue of lung" EXACT [] synonym: "lung interstitial tissue" RELATED [] synonym: "lung interstitium" RELATED [] synonym: "lung portion of connective tissue" EXACT [] synonym: "lung textus connectivus" EXACT [] synonym: "portion of connective tissue of lung" EXACT [] synonym: "textus connectivus of lung" EXACT [] is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0000115 name: lung epithelium def: "the epithelial layer of the lung." [] synonym: "epithelial tissue of lung" EXACT [] synonym: "epithelium of lung" EXACT [] synonym: "lung epithelial tissue" EXACT [] synonym: "pulmonary epithelium" RELATED [] is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002048 ! lung relationship: develops_from UBERON:0001041 ! foregut relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0000117 name: respiratory tube def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." [] synonym: "respiratory conducting tube" NARROW [] synonym: "segment of tracheobronchial tree" EXACT [] synonym: "segment of tracheobronchial tree" NARROW [] synonym: "tracheobronchial tree segment" NARROW [] is_a: UBERON:0000025 ! tube is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000025 ! tube intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract [Term] id: UBERON:0000118 name: lung bud def: "Structure derived from foregut that becomes a lung[GO]." [] synonym: "gemma pulmonalis" RELATED [] synonym: "gemma respiratoria" RELATED [] synonym: "lung bud" RELATED [] synonym: "primary lung bud" RELATED [] synonym: "respiratory diverticulum" RELATED [] is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0005911 ! endo-epithelium relationship: develops_from UBERON:0005597 ! lung primordium relationship: develops_from UBERON:0008947 ! respiratory primordium [Term] id: UBERON:0000119 name: cell layer def: "Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium." [] synonym: "cell sheath" RELATED [] synonym: "layer of cells" EXACT [] synonym: "sheath of cells" RELATED [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0000121 name: perineurium def: "A layer of thin, concentrically arranged cells with interspersed collagen that lies within the epineurium. (Nolte, J., The Human Brain 3rd edition)" [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0000122 name: neuron projection bundle def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [] synonym: "funiculus" EXACT [] synonym: "nerve fiber bundle" EXACT [] synonym: "neural fiber bundle" EXACT [] is_a: UBERON:0005162 ! multi cell component structure relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0000125 name: neural nucleus def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)" [] synonym: "nervous system nucleus" EXACT [] synonym: "neuraxis nucleus" EXACT [] synonym: "neuronal nucleus" EXACT [] synonym: "nucleus" BROAD [] synonym: "nucleus of CNS" EXACT [] synonym: "nucleus of neuraxis" RELATED [] is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0000153 name: anterior region of body is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0000158 name: membranous layer synonym: "membranous organ component" EXACT [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0000159 name: anal canal def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [] synonym: "anal canal" EXACT [] synonym: "anal canal viewed anatomically" EXACT [] synonym: "anal pad" RELATED [] synonym: "anatomical anal canal" EXACT [] synonym: "anus" RELATED [] synonym: "canalis analis" RELATED [] synonym: "cloaca" RELATED [] synonym: "cloacal chamber" RELATED [] synonym: "mesenteron" RELATED [] synonym: "pars analis recti" RELATED [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0011272 ! embryonic skin basal layer relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0000160 name: intestine def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." [] synonym: "bowel" EXACT [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0000162 name: cloaca def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures" [] synonym: "cloacal chamber" RELATED [] synonym: "vent" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0004122 ! genitourinary system [Term] id: UBERON:0000163 name: embryonic cloaca def: "endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." [] synonym: "cloaca" RELATED [] is_a: UBERON:0000162 ! cloaca is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0012361 ! internal anal region [Term] id: UBERON:0000164 name: primitive urogenital sinus def: "Ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females[MP]." [] synonym: "fetal UGS" EXACT [] synonym: "sinus urogenitalis" EXACT [] synonym: "UGS" EXACT [] synonym: "urogenital sinus" BROAD [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: part_of UBERON:0000163 ! embryonic cloaca relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0000165 name: mouth def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes teeth, gums, lips, tongue and parts of the palate." [] synonym: "adult mouth" NARROW [] synonym: "cavital oralis" RELATED [] synonym: "cavitas oris" RELATED [] synonym: "cavum oris" RELATED [] synonym: "mouth cavity" RELATED [] synonym: "oral region" RELATED [] synonym: "oral vestibule" RELATED [] synonym: "regio oralis" EXACT [] synonym: "rima oris" RELATED [] synonym: "stoma" RELATED [] synonym: "stomatodaeum" RELATED [] synonym: "vestibule of mouth" RELATED [] synonym: "vestibulum oris" RELATED [] is_a: UBERON:0004906 ! ectodermal part of digestive tract relationship: develops_from UBERON:0000930 ! stomodeum relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0000168 name: segment of colon def: "An organ segment that is part of a colon [Automatically generated definition]." [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0000063 ! organ segment intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0000170 name: pair of lungs synonym: "lungs" EXACT [] synonym: "lungs pair" EXACT [] synonym: "pulmones" EXACT [] synonym: "set of lungs" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0000171 name: respiration organ def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [] synonym: "apparatus respiratorius organ" EXACT [] synonym: "breathing organ" EXACT [] synonym: "gas exchange organ" RELATED [] synonym: "organ of apparatus respiratorius" EXACT [] synonym: "organ of respiratory system" EXACT [] synonym: "respiratory organ" EXACT [] synonym: "respiratory system organ" EXACT [] is_a: UBERON:0000062 ! organ relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0000173 name: amniotic fluid def: "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." [] synonym: "acqua amnii" RELATED [] synonym: "liquor amnii" RELATED [] is_a: UBERON:0000463 ! portion of organism substance [Term] id: UBERON:0000178 name: blood def: "Circulating body substance which consists of blood plasma and hemoglobin-carrying red blood cells. Excludes blood analogues (see UBERON:0000179 haemolymphatic fluid)." [] synonym: "portion of blood" EXACT [] synonym: "vertebrate blood" EXACT [] synonym: "whole blood" RELATED [] is_a: UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0000179 name: haemolymphatic fluid def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." [] synonym: "blood or blood analog" RELATED [] is_a: UBERON:0000463 ! portion of organism substance intersection_of: UBERON:0000463 ! portion of organism substance intersection_of: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0002390 ! hematopoietic system [Term] id: UBERON:0000203 name: pallium def: "Dorsal part (roof region) of the telencephalon[GO]." [] synonym: "area dorsalis telencephali" EXACT [] synonym: "dorsal part of telencephalon" EXACT [] synonym: "dorsal telencephalic area" EXACT [] synonym: "dorsal telencephalon" EXACT [] is_a: UBERON:0011300 ! gray matter of telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0000204 name: ventral part of telencephalon def: "Dorsal part (base region) of the telencephalon." [] synonym: "area ventralis telencephali" EXACT [] synonym: "subpallium" EXACT [] synonym: "subpallium" NARROW [] synonym: "ventral telencephalon" EXACT [] is_a: UBERON:0002791 ! regional part of telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0000211 name: ligament def: "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." [] synonym: "ligament organ" EXACT [] is_a: UBERON:0007846 ! dense regular connective tissue [Term] id: UBERON:0000305 name: amnion def: "A membrane building the amniotic sac that surrounds and protects an embryo. It is developed in reptiles, birds, and mammals, which are hence called 'Amniota'; but not in amphibians and fish (Ichthyopsida), which are consequently termed 'Anamniota'. The primary function of this is the protection of the embryo for its development. It stems from parts of the mesoderm on the outer side and the ectoderm on the inner side[WP]." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0005971 ! amniotic fold [Term] id: UBERON:0000307 name: blastula def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [] synonym: "blastosphere" RELATED [] synonym: "blastula embryo" EXACT [] is_a: UBERON:0000922 ! embryo relationship: develops_from UBERON:0007010 ! cleaving embryo [Term] id: UBERON:0000310 name: breast def: "The breast is the upper ventral region of an animal's torso, particularly that of mammals, including human beings. The breasts of a female primates body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's. [WP,unvetted]." [] synonym: "mamma" RELATED [] synonym: "mammary part of chest" EXACT [] synonym: "mammary region" EXACT [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0000314 name: cecum mucosa def: "A mucosa that is part of a cecum [Automatically generated definition]." [] synonym: "caecum mucosa" EXACT [] synonym: "caecum mucosa of organ" EXACT [] synonym: "caecum mucous membrane" EXACT [] synonym: "caecum organ mucosa" EXACT [] synonym: "Cecal mucosa" EXACT [] synonym: "cecum mucosa of organ" EXACT [] synonym: "cecum mucous membrane" EXACT [] synonym: "cecum organ mucosa" EXACT [] synonym: "intestinum crassum caecum mucosa" EXACT [] synonym: "intestinum crassum caecum mucosa of organ" EXACT [] synonym: "intestinum crassum caecum mucous membrane" EXACT [] synonym: "intestinum crassum caecum organ mucosa" EXACT [] synonym: "mucosa of caecum" EXACT [] synonym: "mucosa of cecum" EXACT [] synonym: "mucosa of intestinum crassum caecum" EXACT [] synonym: "mucosa of organ of caecum" EXACT [] synonym: "mucosa of organ of cecum" EXACT [] synonym: "mucosa of organ of intestinum crassum caecum" EXACT [] synonym: "mucous membrane of caecum" EXACT [] synonym: "mucous membrane of cecum" EXACT [] synonym: "mucous membrane of intestinum crassum caecum" EXACT [] synonym: "organ mucosa of caecum" EXACT [] synonym: "organ mucosa of cecum" EXACT [] synonym: "organ mucosa of intestinum crassum caecum" EXACT [] is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: UBERON:0000317 name: colonic mucosa def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [] synonym: "colon mucosa" EXACT [] synonym: "colon mucosa of organ" EXACT [] synonym: "colon mucous membrane" EXACT [] synonym: "colon organ mucosa" EXACT [] synonym: "colonic mucosa" EXACT [] synonym: "colonic mucous membrane" EXACT [] synonym: "large bowel mucosa" EXACT [] synonym: "large bowel mucosa of organ" EXACT [] synonym: "large bowel mucous membrane" EXACT [] synonym: "large bowel organ mucosa" EXACT [] synonym: "mucosa of colon" EXACT [] synonym: "mucosa of large bowel" EXACT [] synonym: "mucosa of organ of colon" EXACT [] synonym: "mucosa of organ of large bowel" EXACT [] synonym: "mucosa of segment of colon" EXACT [] synonym: "mucous membrane of colon" EXACT [] synonym: "mucous membrane of large bowel" EXACT [] synonym: "organ mucosa of colon" EXACT [] synonym: "organ mucosa of large bowel" EXACT [] is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0000320 name: duodenal mucosa def: "A mucosa that is part of a duodenum [Automatically generated definition]." [] synonym: "Doudenal mucosa" EXACT [] synonym: "Duodenal mucous membrane" EXACT [] synonym: "duodenum mucosa" RELATED [] synonym: "mucosa of duodenum" EXACT [] synonym: "mucous membrane of duodenum" EXACT [] is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: UBERON:0000325 name: gastric gland def: "any of the branched tubules in the inner lining of the stomach that secrete gastric juice and protective mucus." [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003294 ! gland of foregut relationship: part_of UBERON:0006924 ! stomach glandular epithelium [Term] id: UBERON:0000331 name: ileal mucosa def: "A mucosa that is part of a ileum [Automatically generated definition]." [] synonym: "ileal mucous membrane" EXACT [] synonym: "ileum mucosa" EXACT [] synonym: "ileum mucosa of organ" EXACT [] synonym: "ileum mucous membrane" EXACT [] synonym: "ileum organ mucosa" EXACT [] synonym: "mucosa of ileum" EXACT [] synonym: "mucosa of organ of ileum" EXACT [] synonym: "mucous membrane of ileum" EXACT [] synonym: "organ mucosa of ileum" EXACT [] is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: UBERON:0000333 name: intestinal gland def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." [] synonym: "bowel mucosa gland" EXACT [] synonym: "bowel mucosa of organ gland" EXACT [] synonym: "bowel mucous membrane gland" EXACT [] synonym: "bowel organ mucosa gland" EXACT [] synonym: "crypt of Lieberkuehn" RELATED [] synonym: "gland of bowel mucosa" EXACT [] synonym: "gland of bowel mucosa of organ" EXACT [] synonym: "gland of bowel mucous membrane" EXACT [] synonym: "gland of bowel organ mucosa" EXACT [] synonym: "gland of intestinal mucosa" EXACT [] synonym: "gland of intestine mucosa" EXACT [] synonym: "gland of intestine mucosa of organ" EXACT [] synonym: "gland of intestine mucous membrane" EXACT [] synonym: "gland of intestine organ mucosa" EXACT [] synonym: "gland of Lieberkuehn" RELATED [] synonym: "gland of mucosa of bowel" EXACT [] synonym: "gland of mucosa of intestine" EXACT [] synonym: "gland of mucosa of organ of bowel" EXACT [] synonym: "gland of mucosa of organ of intestine" EXACT [] synonym: "gland of mucous membrane of bowel" EXACT [] synonym: "gland of mucous membrane of intestine" EXACT [] synonym: "gland of organ mucosa of bowel" EXACT [] synonym: "gland of organ mucosa of intestine" EXACT [] synonym: "glandula intestinalis" EXACT [] synonym: "glandulae intestinales" RELATED [] synonym: "intestinal mucosa gland" EXACT [] synonym: "intestine mucosa gland" EXACT [] synonym: "intestine mucosa of organ gland" EXACT [] synonym: "intestine mucous membrane gland" EXACT [] synonym: "intestine organ mucosa gland" EXACT [] synonym: "Lieberkuehn`s gland" RELATED [] synonym: "mucosa of bowel gland" EXACT [] synonym: "mucosa of intestine gland" EXACT [] synonym: "mucosa of organ of bowel gland" EXACT [] synonym: "mucosa of organ of intestine gland" EXACT [] synonym: "mucous membrane of bowel gland" EXACT [] synonym: "mucous membrane of intestine gland" EXACT [] synonym: "organ mucosa of bowel gland" EXACT [] synonym: "organ mucosa of intestine gland" EXACT [] is_a: UBERON:0003408 ! gland of gut intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001242 ! intestinal mucosa relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0000344 name: mucosa def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]" [] synonym: "mucosa of organ" EXACT [] synonym: "mucosa of organ part" EXACT [] synonym: "mucosal region" EXACT [] synonym: "mucous membrane" EXACT [] synonym: "organ mucosa" EXACT [] synonym: "region of mucosa" RELATED [] synonym: "tunica mucosa" RELATED [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0000349 name: limbic system def: "A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex]. including the hippocampus, amygdala, anterior thalamic nuclei, and limbic cortex, which support a variety of functions including emotion, behavior, long term memory, and olfaction [Wikipedia]." [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0000353 name: parenchyma def: "functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin[WP]." [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000355 name: pharyngeal mucosa def: "A mucosa that is part of a pharynx [Automatically generated definition]." [] synonym: "mucosa of organ of pharynx" EXACT [] synonym: "mucosa of pharynx" EXACT [] synonym: "Mucous membrane of pharynx" EXACT [] synonym: "mucous membrane of pharynx" EXACT [] synonym: "mucous membrane of the pharynx" RELATED [] synonym: "organ mucosa of pharynx" EXACT [] synonym: "pharynx mucosa" EXACT [] synonym: "pharynx mucosa of organ" EXACT [] synonym: "pharynx mucous membrane" EXACT [] synonym: "pharynx organ mucosa" EXACT [] synonym: "tunica mucosa pharyngea" EXACT [] synonym: "tunica mucosa pharyngis" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0000358 name: blastocyst def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." [] synonym: "blastocystis" RELATED [] synonym: "blastula" RELATED [] is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000085 ! morula relationship: part_of UBERON:0000307 ! blastula [Term] id: UBERON:0000362 name: renal medulla def: "The renal medulla is the innermost part of the kidney. The renal medulla is split up into a number of sections, known as the renal pyramids. Blood enters into the kidney via the renal artery, which then splits up to form the arcuate arterioles. The arcuate arterioles each in turn branch into interlobular arterioles, which finally reach the glomeruli. At the glomerulus the blood reaches a highly disfavourable pressure gradient and a large exchange surface area, which forces the serum portion of the blood out of the vessel into the renal tubules. Flow continues through the renal tubules, including the proximal tubule, the Loop of Henle, and finally leaves the kidney by means of the collecting duct, leading to the renal ureter. The renal medulla (latin renes medulla = kidney middle) contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. The renal medulla is hypertonic to the filtrate in the nephron and aids in the reabsorption of water. [WP,unvetted]." [] synonym: "kidney medulla" EXACT [] synonym: "medulla of kidney" EXACT [] synonym: "medulla renalis" EXACT [] synonym: "medullary pyramids" EXACT [] synonym: "pyramides renales" EXACT [] synonym: "renal marrow" RELATED [] synonym: "renal medullae" EXACT [] synonym: "renal medullae set" EXACT [] synonym: "renal pyramids" EXACT [] synonym: "renal pyramids set" EXACT [] is_a: UBERON:0000958 ! medulla is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000958 ! medulla intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0000365 name: urothelium def: "The urothelium is the epithelial tissue layer that lines much of the urinary tract, including the renal pelvis, the ureters, the bladder, and parts of the urethra." [] synonym: "transitional epithelium" BROAD [] synonym: "uroepithelium" EXACT [] is_a: UBERON:0005910 ! transitional epithelium is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0005910 ! transitional epithelium intersection_of: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0000369 name: corpus striatum def: "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." [] synonym: "striate body" RELATED [] synonym: "striated body" RELATED [] is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0002420 ! basal ganglion [Term] id: UBERON:0000378 name: tongue muscle def: "the muscular portion of the tongue." [] synonym: "muscle of tongue" EXACT [] synonym: "muscle organ of tongue" EXACT [] synonym: "musculi linguae" RELATED [] is_a: UBERON:0002376 ! muscle of head is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0013765 ! digestive system organ union_of: UBERON:0001575 ! extrinsic muscle of tongue union_of: UBERON:0001576 ! intrinsic muscle of tongue relationship: develops_from UBERON:0005594 ! head somite relationship: part_of UBERON:0004477 ! tongue musculature [Term] id: UBERON:0000379 name: tracheal mucosa def: "A mucosa that is part of a respiratory airway." [] synonym: "mucosa of organ of trachea" EXACT [] synonym: "mucosa of organ of windpipe" EXACT [] synonym: "mucosa of trachea" EXACT [] synonym: "mucosa of windpipe" EXACT [] synonym: "Mucous membrane of trachea" EXACT [] synonym: "mucous membrane of trachea" EXACT [] synonym: "mucous membrane of windpipe" EXACT [] synonym: "organ mucosa of trachea" EXACT [] synonym: "organ mucosa of windpipe" EXACT [] synonym: "trachea mucosa" EXACT [] synonym: "trachea mucosa of organ" EXACT [] synonym: "trachea mucous membrane" EXACT [] synonym: "trachea organ mucosa" EXACT [] synonym: "Tracheal mucous membrane" EXACT [] synonym: "Tunica mucosa (tracheae)" EXACT [] synonym: "tunica mucosa tracheae" EXACT [] synonym: "windpipe mucosa" EXACT [] synonym: "windpipe mucosa of organ" EXACT [] synonym: "windpipe mucous membrane" EXACT [] synonym: "windpipe organ mucosa" EXACT [] is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001005 ! respiratory airway relationship: part_of UBERON:0001005 ! respiratory airway [Term] id: UBERON:0000383 name: musculature of body def: "Anatomical system that consists of all the muscles of the body[VSAO, modified]." [] synonym: "muscle system" EXACT [] synonym: "muscle system of body" EXACT [] synonym: "muscular system" EXACT [] synonym: "musculature system" EXACT [] synonym: "muskelsystem" RELATED [] synonym: "set of all muscles" EXACT [] synonym: "set of muscles of body" EXACT [] synonym: "vertebrate muscular system" EXACT [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] id: UBERON:0000395 name: cochlear ganglion def: "group of nerve cells that serve the sense of hearing by sending a representation of sound from the cochlea to the brain. The cell bodies of the spiral ganglion neurons are found in the spiral structure of the cochlea[WP]. the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]." [] synonym: "Corti's ganglion" EXACT [] synonym: "ganglion cochlearis" RELATED [] synonym: "ganglion of Corti" EXACT [] synonym: "ganglion spirale" RELATED [] synonym: "ganglion spirale cochleae" RELATED [] synonym: "spiral ganglion" EXACT [] synonym: "spiral ganglion of cochlea" RELATED [] synonym: "vestibulocochlear VIII ganglion cochlear component" EXACT [] is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0002827 ! auditory ganglion [Term] id: UBERON:0000397 name: colonic epithelium def: "An epithelium that is part of a colon [Automatically generated definition]." [] synonym: "colon epithelial tissue" EXACT [] synonym: "Colon epithelium" EXACT [] synonym: "colon epithelium" EXACT [] synonym: "epithelial tissue of colon" EXACT [] synonym: "epithelial tissue of large bowel" EXACT [] synonym: "epithelium of colon" EXACT [] synonym: "epithelium of large bowel" EXACT [] synonym: "large bowel epithelial tissue" EXACT [] synonym: "large bowel epithelium" EXACT [] synonym: "posterior intestine epithelium" EXACT [] is_a: UBERON:0001278 ! epithelium of large intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0000399 name: jejunal mucosa def: "A mucosa that is part of a jejunum [Automatically generated definition]." [] synonym: "jejunal mucous membrane" EXACT [] synonym: "jejunum mucosa" EXACT [] synonym: "jejunum mucosa of organ" EXACT [] synonym: "jejunum mucous membrane" EXACT [] synonym: "jejunum organ mucosa" EXACT [] synonym: "mucosa of jejunum" EXACT [] synonym: "mucosa of organ of jejunum" EXACT [] synonym: "mucous membrane of jejunum" EXACT [] synonym: "organ mucosa of jejunum" EXACT [] is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0000400 name: jejunal epithelium def: "An epithelium that is part of a jejunum." [] synonym: "epithelium of jejunum" EXACT [] is_a: UBERON:0013636 ! epithelium of intestinal villus intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0008343 ! intestinal villus of jejunum [Term] id: UBERON:0000410 name: bronchial mucosa def: "A mucosa that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi mucosa" EXACT [] synonym: "bronchi mucosa of organ" EXACT [] synonym: "bronchi mucous membrane" EXACT [] synonym: "bronchi organ mucosa" EXACT [] synonym: "bronchial trunk mucosa" EXACT [] synonym: "bronchial trunk mucosa of organ" EXACT [] synonym: "bronchial trunk mucous membrane" EXACT [] synonym: "bronchial trunk organ mucosa" EXACT [] synonym: "bronchus mucosa" EXACT [] synonym: "bronchus mucosa of organ" EXACT [] synonym: "bronchus mucous membrane" EXACT [] synonym: "bronchus organ mucosa" EXACT [] synonym: "mucosa of bronchi" EXACT [] synonym: "mucosa of bronchial trunk" EXACT [] synonym: "mucosa of bronchus" EXACT [] synonym: "mucosa of organ of bronchi" EXACT [] synonym: "mucosa of organ of bronchial trunk" EXACT [] synonym: "mucosa of organ of bronchus" EXACT [] synonym: "mucous membrane of bronchi" EXACT [] synonym: "mucous membrane of bronchial trunk" EXACT [] synonym: "Mucous membrane of bronchus" EXACT [] synonym: "mucous membrane of bronchus" EXACT [] synonym: "organ mucosa of bronchi" EXACT [] synonym: "organ mucosa of bronchial trunk" EXACT [] synonym: "organ mucosa of bronchus" EXACT [] synonym: "tunica mucosa bronchi" EXACT [] is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0000412 name: dermal papilla def: "small, nipple-like extensions (or interdigitations) of the dermis into the epidermis. They can be observed at the surface of the skin in hands and feet as epidermal or papillary ridges (colloquially known as fingerprints). The dermal papillae nourishes all hair follicles and bring food and oxygen to the lower layers of epidermal cells. The pattern of ridges they produce in hands and feet are inherited features that are developed before birth. They remain unaltered (except size) throughout life, and are therefore used for fingerprints. The dermal papillae are part of the uppermost layer of the dermis, the papillary dermis, and the ridges they form greatly increase the surface area between the dermis and epidermis. Because the dermis' main function is to support the epidermis, this greatly increases the exchange of oxygen, nutrients, and waste products between these two layers. Additionally, the increase in surface area prevent the dermal and epidermal layers from separating from each others by strengthening the junction between them. With age, the papillae tend to flatten and sometimes increase in numbers. Dermal papillae also play a pivotal role in hair formation, growth and, cycling" [] synonym: "dermal papilla cell" RELATED [] synonym: "dermal papillae" EXACT [] synonym: "DPC" RELATED [] synonym: "follicular papilla" EXACT [] synonym: "hair follicle dermal papilla" RELATED [] synonym: "papilla corii" RELATED [] synonym: "papilla dermatis" RELATED [] synonym: "papilla dermis" RELATED [] synonym: "papilla of corium" RELATED [] synonym: "papillae dermis" RELATED [] synonym: "skin papilla" RELATED [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001992 ! papillary layer of dermis [Term] id: UBERON:0000414 name: mucous gland def: "A gland in which the principal secretory cells are mucus secreting cells." [] synonym: "glandula mucosa" RELATED [] synonym: "muciparous gland" RELATED [] synonym: "mucous secreting gland" RELATED [] synonym: "mucus gland" RELATED [] is_a: UBERON:0002365 ! exocrine gland [Term] id: UBERON:0000415 name: artery wall def: "An anatomical wall that is part of an artery [Automatically generated definition]." [] synonym: "Arterial wall" EXACT [] synonym: "wall of artery" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0000428 name: prostate epithelium def: "the prostate epithelium." [] synonym: "epithelial tissue of prostate" EXACT [] synonym: "epithelial tissue of prostate gland" EXACT [] synonym: "epithelium of prostate" EXACT [] synonym: "epithelium of prostate gland" EXACT [] synonym: "epithelium of prostatic gland" EXACT [] synonym: "prostate epithelial tissue" EXACT [] synonym: "prostate gland epithelial tissue" EXACT [] synonym: "prostate gland epithelium" EXACT [] synonym: "prostatic epithelium" EXACT [] synonym: "prostatic gland epithelium" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0000444 name: lymphoid follicle def: "." [] synonym: "folliculus lymphaticus" RELATED [] synonym: "lymphatic follicle" RELATED [] synonym: "lymphatic nodule" RELATED [] synonym: "lymphoid nodule" EXACT [] synonym: "nodular lymphoid tissue" EXACT [] synonym: "nodulus lymphaticus" RELATED [] synonym: "nodulus lymphoideus" RELATED [] is_a: UBERON:0001744 ! lymphoid tissue [Term] id: UBERON:0000458 name: endocervix def: "1. The mucous membrane lining the canal of the cervix uteri. 2. The region of the opening of the uterine cervix into the uterine cavity." [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure [Term] id: UBERON:0000459 name: uterine wall def: "An anatomical wall that is part of a uterus [Automatically generated definition]." [] synonym: "anatomical wall of uterus" EXACT [] synonym: "uterus anatomical wall" EXACT [] synonym: "uterus wall" EXACT [] synonym: "wall of uterus" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus [Term] id: UBERON:0000463 name: portion of organism substance def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [] synonym: "body fluid or substance" EXACT [] synonym: "body substance" EXACT [] synonym: "organism substance" EXACT [] synonym: "portion of body substance" EXACT [] is_a: UBERON:0000465 ! material anatomical entity relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0000464 name: anatomical space def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [] synonym: "lumen" BROAD [] synonym: "lumen space" EXACT [] synonym: "space" BROAD [] is_a: UBERON:0000466 ! immaterial anatomical entity [Term] id: UBERON:0000465 name: material anatomical entity def: "Anatomical entity that has mass." [] is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000466 name: immaterial anatomical entity def: "Anatomical entity that has no mass." [] synonym: "immaterial physical anatomical entity" EXACT [] is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000467 name: anatomical system def: "Anatomical group that is has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity[CARO]. A group of organs that work together to perform a certain task [Wikipedia]." [] synonym: "body system" EXACT [] synonym: "organ system" EXACT [] synonym: "system" BROAD [] is_a: UBERON:0000480 ! anatomical group relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0000468 name: multi-cellular organism def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [] synonym: "animal" NARROW [] synonym: "body" RELATED [] synonym: "Koerper" RELATED [] synonym: "organism" EXACT [] synonym: "whole body" RELATED [] synonym: "whole organism" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0000471 name: compound organ component def: "Multi-tissue structure that is part of a compound organ." [] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: UBERON:0000473 name: testis def: "gonad of a male animal, produces and releases sperm." [] synonym: "genitalia of male organism gonad" EXACT [] synonym: "genitalia of male organism gonada" EXACT [] synonym: "gonad of genitalia of male organism" EXACT [] synonym: "gonad of male genitalia" EXACT [] synonym: "gonad of male genitals" EXACT [] synonym: "gonad of male organism genitalia" EXACT [] synonym: "gonad of male organism reproductive system" EXACT [] synonym: "gonad of male reproductive system" EXACT [] synonym: "gonad of reproductive system of male organism" EXACT [] synonym: "gonada of genitalia of male organism" EXACT [] synonym: "gonada of male genitalia" EXACT [] synonym: "gonada of male genitals" EXACT [] synonym: "gonada of male organism genitalia" EXACT [] synonym: "gonada of male organism reproductive system" EXACT [] synonym: "gonada of male reproductive system" EXACT [] synonym: "gonada of reproductive system of male organism" EXACT [] synonym: "male genitalia gonad" EXACT [] synonym: "male genitalia gonada" EXACT [] synonym: "male genitals gonad" EXACT [] synonym: "male gonad" EXACT [] synonym: "male organism genitalia gonad" EXACT [] synonym: "male organism genitalia gonada" EXACT [] synonym: "male organism reproductive system gonad" EXACT [] synonym: "male organism reproductive system gonada" EXACT [] synonym: "male reproductive system gonad" EXACT [] synonym: "male reproductive system gonada" EXACT [] synonym: "orchis" RELATED [] synonym: "reproductive system of male organism gonad" EXACT [] synonym: "reproductive system of male organism gonada" EXACT [] synonym: "testes" RELATED [] synonym: "testicle" EXACT [] synonym: "testiculus" RELATED [] is_a: UBERON:0000991 ! gonad is_a: UBERON:0003135 ! male reproductive organ intersection_of: UBERON:0000991 ! gonad intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: develops_from UBERON:0009117 ! indifferent gonad relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0000474 name: female reproductive system def: "The organs of the female reproductive system." [] synonym: "female genital system" RELATED [] synonym: "female genitalia" RELATED [] synonym: "female organism genitalia" EXACT [] synonym: "female organism reproductive system" EXACT [] synonym: "female reproductive tract" RELATED [] synonym: "genitalia of female organism" EXACT [] synonym: "gynaecological tissue" RELATED [] synonym: "reproductive system of female organism" EXACT [] synonym: "systema genitale femininum" RELATED [] is_a: UBERON:0000990 ! reproductive system is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000990 ! reproductive system intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0003100 ! female organism [Term] id: UBERON:0000475 name: organism subdivision def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [] synonym: "anatomic region" EXACT [] synonym: "body part" RELATED [] synonym: "body region" RELATED [] synonym: "cardinal body part" RELATED [] is_a: UBERON:0010000 ! multicellular anatomical structure relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0000477 name: anatomical cluster def: "Anatomical group that has its parts adjacent to one another." [] is_a: UBERON:0000480 ! anatomical group [Term] id: UBERON:0000478 name: extraembryonic structure def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [] synonym: "extra-embryonic structure" EXACT [] synonym: "extraembryonic component" RELATED [] synonym: "extraembryonic tissue" RELATED [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0000479 name: tissue def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [] synonym: "portion of tissue" EXACT [] synonym: "simple tissue" NARROW [] synonym: "tissue portion" EXACT [] is_a: UBERON:0010000 ! multicellular anatomical structure relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0000480 name: anatomical group def: "Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue." [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0000481 name: multi-tissue structure def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000483 name: epithelium def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." [] synonym: "epithelial tissue" EXACT [] synonym: "portion of epithelium" EXACT [] is_a: UBERON:0000119 ! cell layer union_of: UBERON:0000486 ! multilaminar epithelium union_of: UBERON:0000490 ! unilaminar epithelium [Term] id: UBERON:0000484 name: simple cuboidal epithelium def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [] synonym: "epithelium simplex cuboideum" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010077 ! cuboidal epithelium [Term] id: UBERON:0000485 name: simple columnar epithelium def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]" [] synonym: "columnar epithelium" BROAD [] synonym: "columnar epithlium" BROAD [] synonym: "epithelium simplex columnare" EXACT [] synonym: "simple columnar epithelium" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium [Term] id: UBERON:0000486 name: multilaminar epithelium def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]" [] synonym: "laminated epithelium" RELATED [] synonym: "stratified epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000487 name: simple squamous epithelium def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]" [] synonym: "epithelium simplex squamosum" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium [Term] id: UBERON:0000488 name: atypical epithelium def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [] synonym: "heterogenous epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000489 name: cavitated compound organ def: "Compound organ that contains one or more macroscopic anatomical spaces." [] synonym: "cavitated organ" EXACT [] is_a: UBERON:0003103 ! compound organ [Term] id: UBERON:0000490 name: unilaminar epithelium def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]" [] synonym: "simple epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000915 name: thoracic segment of trunk def: "Organismal subdivision of body that lies between the head and the abdomen [Wikipedia]." [] synonym: "thorax" RELATED [] synonym: "upper body" RELATED [] is_a: UBERON:0009569 ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis [Term] id: UBERON:0000916 name: abdomen def: "In vertebrates such as mammals the abdomen (belly) constitutes the part of the body between the thorax (chest) and pelvis. The region enclosed by the abdomen is termed the abdominal cavity." [] synonym: "abdominopelvic region" EXACT [] synonym: "abdominopelvis" EXACT [] synonym: "adult abdomen" RELATED [] synonym: "belly" RELATED [] synonym: "celiac region" RELATED [] is_a: UBERON:0009569 ! subdivision of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0000922 name: embryo def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [] synonym: "developing organism" RELATED [] synonym: "developmental tissue" RELATED [] synonym: "embryonic organism" EXACT [] is_a: UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0000923 name: germ layer def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." [] synonym: "embryonic germ layer" RELATED [] synonym: "embryonic germ layers" RELATED [] synonym: "embryonic tissue" BROAD [] synonym: "germinal layer" EXACT [] synonym: "primary germ layer" NARROW [] is_a: UBERON:0010316 ! germ layer / neural crest relationship: develops_from UBERON:0002532 ! epiblast (generic) relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0000924 name: ectoderm def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [] synonym: "embryonic ectoderm" EXACT [] is_a: UBERON:0000923 ! germ layer relationship: develops_from UBERON:0006601 ! presumptive ectoderm [Term] id: UBERON:0000925 name: endoderm def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." [] synonym: "entoderm" RELATED [] is_a: UBERON:0000923 ! germ layer relationship: develops_from UBERON:0006595 ! presumptive endoderm [Term] id: UBERON:0000926 name: mesoderm def: "The middle germ layer of the embryo, between the endoderm and ectoderm." [] synonym: "embryonic mesoderm" RELATED [] synonym: "entire mesoderm" RELATED [] synonym: "mesodermal mantle" RELATED [] is_a: UBERON:0000923 ! germ layer relationship: develops_from UBERON:0006603 ! presumptive mesoderm [Term] id: UBERON:0000930 name: stomodeum def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." [] synonym: "mouth pit" RELATED [] synonym: "mouth primordium" EXACT [] synonym: "oral pit" RELATED [] synonym: "primitive oral cavity" EXACT [] synonym: "stomatodeum" EXACT [] synonym: "stomodaeum" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000924 ! ectoderm relationship: part_of UBERON:0007026 ! primitive gut [Term] id: UBERON:0000945 name: stomach def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." [] synonym: "anterior intestine" RELATED [] synonym: "gaster" RELATED [] synonym: "mesenteron" RELATED [] synonym: "stomach chamber" NARROW [] synonym: "Ventricular" RELATED [] synonym: "ventriculus" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0010039 ! food storage organ relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0000947 name: aorta def: "Artery carrying blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation" [] synonym: "arteria maxima" RELATED [] synonym: "dorsal aorta" NARROW [] synonym: "trunk of aortic tree" EXACT [] synonym: "trunk of systemic arterial tree" EXACT [] is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:0013768 ! great vessel of heart relationship: part_of UBERON:0004571 ! systemic arterial system relationship: part_of UBERON:0010191 ! aortic system [Term] id: UBERON:0000948 name: heart def: "a myogenic muscular organ found in the cardiovascular system. It is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. The vertebrate heart is composed of cardiac muscle, which is an involuntary striated muscle tissue found only in this organ, and connective tissue. Primitive fish have a four-chambered heart; however, the chambers are arranged sequentially so that this primitive heart is quite unlike the four-chambered hearts of mammals and birds. The first chamber is the sinus venosus, which collects de-oxygenated blood, from the body, through the hepatic and cardinal veins. From here, blood flows into the atrium and then to the powerful muscular ventricle where the main pumping action takes place. The fourth and final chamber is the conus arteriosus which contains several valves and sends blood to the ventral aorta. The ventral aorta delivers blood to the gills where it is oxygenated and flows, through the dorsal aorta, into the rest of the body. (In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary artery. In the adult fish, the four chambers are not arranged in a straight row but, instead, form an S-shape with the latter two chambers lying above the former two. This relatively simpler pattern is found in cartilaginous fish and in the more primitive ray-finned fish. In teleosts, the conus arteriosus is very small and can more accurately be described as part of the aorta rather than of the heart proper. The conus arteriosus is not present in any amniotes which presumably having been absorbed into the ventricles over the course of evolution. Similarly, while the sinus venosus is present as a vestigial structure in some reptiles and birds, it is otherwise absorbed into the right atrium and is no longer distinguishable[WP]." [] synonym: "branchial heart" NARROW [] synonym: "chambered heart" EXACT [] synonym: "Herz" RELATED [] synonym: "vertebrate heart" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007100 ! circulatory organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0004141 ! heart tube relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0000949 name: endocrine system def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [] synonym: "endocrine glandular system" EXACT [] synonym: "endocrine system" EXACT [] synonym: "systema endocrinum" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0000955 name: brain def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [] synonym: "encephalon" RELATED [] synonym: "suprasegmental levels of nervous system" RELATED [] synonym: "suprasegmental structures" RELATED [] synonym: "synganglion" RELATED [] synonym: "the brain" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0000956 name: cerebral cortex def: "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." [] synonym: "brain cortex" RELATED [] synonym: "central canal, spinal cord/medulla" RELATED [] synonym: "cortex cerebralis" RELATED [] synonym: "cortex cerebri" RELATED [] synonym: "cortex of cerebral hemisphere" EXACT [] synonym: "cortical plate (areas)" RELATED [] synonym: "cortical plate (CTXpl)" RELATED [] synonym: "pallium of the brain" RELATED [] is_a: UBERON:0002791 ! regional part of telencephalon relationship: part_of UBERON:0000203 ! pallium relationship: part_of UBERON:0005401 ! cerebral hemisphere grey matter [Term] id: UBERON:0000958 name: medulla def: "Middle part of an organ (as opposed to the cortex)[WP]." [] is_a: UBERON:0000471 ! compound organ component [Term] id: UBERON:0000961 name: thoracic ganglion def: "The thoracic ganglia are paravertebral ganglia. The thoracic portion of the sympathetic trunk typically has 12 thoracic ganglia. Emerging from the ganglia are thoracic splancic nerves (the cardiopulmonary, the greater, lesser, and least splanchic nerves) that help provide sympathetic innervation to abdominal structures. Also, the ganglia of the thoracic sympathetic trunk have both white and gray rami communicantes. The white rami carry sympathetic fibers arising in the spinal cord into the sympathetic trunk. [WP,unvetted]." [] synonym: "ganglion of thorax" EXACT [] synonym: "ganglion thoracicum splanchnicum" EXACT [] synonym: "thoracic paravertebral ganglion" EXACT [] synonym: "thoracic splanchnic ganglion" EXACT [] synonym: "thoracic sympathetic ganglion" EXACT [] synonym: "thorax ganglion" EXACT [] is_a: UBERON:0001807 ! paravertebral ganglion [Term] id: UBERON:0000964 name: cornea def: "transparent front part of the eye that covers the iris, pupil, and anterior chamber. Together with the lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power." [] synonym: "cornea of camera-type eye" EXACT [] synonym: "tunica cornea" RELATED [] is_a: UBERON:0003102 ! surface structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0004348 ! optic eminence relationship: develops_from UBERON:0005427 ! corneal primordium relationship: part_of UBERON:0001801 ! anterior segment of eyeball relationship: part_of UBERON:0010409 ! eye surface relationship: part_of UBERON:0012430 ! tunica fibrosa of eyeball [Term] id: UBERON:0000965 name: lens of camera-type eye def: "Transparent part of camera-type eye that helps to refract light to be focused on the retina." [] synonym: "camera-type eye lens" EXACT [] synonym: "crystalline lens" RELATED [] synonym: "eye lens" EXACT [] synonym: "lens" EXACT [] synonym: "lens crystallina" EXACT [] synonym: "ocular lens" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005389 ! transparent eye structure relationship: develops_from UBERON:0003073 ! lens placode relationship: develops_from UBERON:0005426 ! lens vesicle relationship: part_of UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0000966 name: retina def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [] synonym: "inner layer of eyeball" EXACT [] synonym: "Netzhaut" RELATED [] synonym: "retina of camera-type eye" EXACT [] synonym: "tunica interna of eyeball" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005388 ! photoreceptor array relationship: develops_from UBERON:0003072 ! optic cup relationship: part_of UBERON:0001802 ! posterior segment of eyeball [Term] id: UBERON:0000970 name: eye def: "An organ that detects light." [] synonym: "light-detecting organ" RELATED [] synonym: "photoreceptor" BROAD [] synonym: "visual apparatus" RELATED [] is_a: UBERON:0000020 ! sense organ relationship: part_of UBERON:0002104 ! visual system [Term] id: UBERON:0000974 name: neck def: "Subdivision of body proper, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the cervical vertebral coumn, it is partially surrounded by skin of neck. Examples: There is only one neck[FMA]." [] synonym: "collum" RELATED [] synonym: "neck (volume)" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0000153 ! anterior region of body relationship: part_of UBERON:0007811 ! craniocervical region [Term] id: UBERON:0000977 name: pleura def: "The delicate serous membrane that lines each half of the thorax of mammals and is folded back over the surface of the lung of the same side[BTO]." [] synonym: "pleura" RELATED [] synonym: "pleural tissue" RELATED [] synonym: "wall of pleural sac" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0009778 ! pleural sac relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0009778 ! pleural sac [Term] id: UBERON:0000982 name: skeletal joint def: "Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." [] synonym: "articular joint" RELATED [] synonym: "articulation" BROAD [] synonym: "joint" BROAD [] is_a: UBERON:0004905 ! articulation union_of: UBERON:0002217 ! synovial joint union_of: UBERON:0011134 ! nonsynovial joint relationship: part_of UBERON:0004770 ! articular system [Term] id: UBERON:0000989 name: penis def: "The penis (plural penises, penes) is an external sexual organ of certain biologically male organisms, in both vertebrates and invertebrates. The penis is a reproductive organ, technically an intromittent organ, and for placental mammals, additionally serves as the external organ of urination. The penis is generally found on mammals and reptiles. [WP,unvetted]." [] synonym: "phallus" RELATED [] is_a: UBERON:0008811 ! intromittent organ relationship: develops_from UBERON:0004876 ! urogenital ridge relationship: develops_from UBERON:0005876 ! undifferentiated genital tubercle [Term] id: UBERON:0000990 name: reproductive system def: "Anatomical system that has as its parts the organs concerned with reproduction." [] synonym: "animal reproductive system" RELATED [] synonym: "genital system" RELATED [] synonym: "genitalia" RELATED [] synonym: "Geschlechtsorgan" RELATED [] synonym: "organa genitalia" RELATED [] synonym: "reproductive tissue" RELATED [] synonym: "systemata genitalia" RELATED [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0000991 name: gonad def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [] synonym: "gonada" EXACT [] is_a: UBERON:0003133 ! reproductive organ relationship: develops_from UBERON:0005564 ! gonad primordium relationship: part_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0000992 name: female gonad def: "Ovum-producing female reproductive organ." [] synonym: "female organism genitalia gonad" EXACT [] synonym: "female organism genitalia gonada" EXACT [] synonym: "female organism reproductive system gonad" EXACT [] synonym: "female organism reproductive system gonada" EXACT [] synonym: "female reproductive system gonad" EXACT [] synonym: "female reproductive system gonada" EXACT [] synonym: "genitalia of female organism gonad" EXACT [] synonym: "genitalia of female organism gonada" EXACT [] synonym: "gonad of female organism genitalia" EXACT [] synonym: "gonad of female organism reproductive system" EXACT [] synonym: "gonad of female reproductive system" EXACT [] synonym: "gonad of genitalia of female organism" EXACT [] synonym: "gonad of reproductive system of female organism" EXACT [] synonym: "gonada of female organism genitalia" EXACT [] synonym: "gonada of female organism reproductive system" EXACT [] synonym: "gonada of female reproductive system" EXACT [] synonym: "gonada of genitalia of female organism" EXACT [] synonym: "gonada of reproductive system of female organism" EXACT [] synonym: "ovaries" RELATED [] synonym: "ovarium" RELATED [] synonym: "ovary" EXACT [] synonym: "ovum-producing ovary" EXACT [] synonym: "reproductive system of female organism gonad" EXACT [] synonym: "reproductive system of female organism gonada" EXACT [] is_a: UBERON:0000991 ! gonad is_a: UBERON:0003134 ! female reproductive organ intersection_of: UBERON:0000991 ! gonad intersection_of: part_of UBERON:0000474 ! female reproductive system relationship: develops_from UBERON:0009117 ! indifferent gonad relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: UBERON:0000993 name: oviduct def: "passage from the ovaries to the outside of the body[Wikipedia:Oviduct]." [] synonym: "tuba uterina" RELATED [] synonym: "tuba uterinae" RELATED [] synonym: "uterine tube" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: UBERON:0000995 name: uterus def: "a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species. It is within the uterus that the fetus develops during gestation, usually developing completely in placental mammals such as humans and partially in marsupials such as kangaroos and opossums. Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused[WP]." [] is_a: UBERON:0013515 ! subdivision of uterine tube relationship: part_of UBERON:0004175 ! internal genitalia [Term] id: UBERON:0000996 name: vagina def: "a fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." [] synonym: "distal oviductal region" RELATED [] synonym: "distal portion of oviduct" RELATED [] synonym: "vaginae" RELATED [] is_a: UBERON:0013515 ! subdivision of uterine tube relationship: develops_from UBERON:0000164 ! primitive urogenital sinus relationship: part_of UBERON:0003975 ! internal female genitalia [Term] id: UBERON:0000998 name: seminal vesicle def: "Either of a pair of glandular pouches that lie one on either side of the male reproductive tract and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct." [] synonym: "glandula seminalis" RELATED [] synonym: "glandula vesiculosa" RELATED [] synonym: "gon_male_sves" RELATED [] synonym: "seminal gland" BROAD [] synonym: "vas efferens" RELATED [] synonym: "vesicula seminalis" RELATED [] synonym: "vesiculae seminales" RELATED [] synonym: "vesicular gland" RELATED [] synonym: "vesicular glands" RELATED [] synonym: "vesicular seminalis" RELATED [] synonym: "vesicul? seminales" RELATED [] synonym: "vesicul seminales" RELATED [] is_a: UBERON:0006868 ! seminal fluid secreting gland relationship: develops_from UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000473 ! testis [Term] id: UBERON:0001003 name: epidermis def: "The outer layer of the skin[WP]. cellular, multilayered epithelium derived from the ectoderm[ZFA]." [] synonym: "adult epidermis" EXACT [] synonym: "skin" BROAD [] synonym: "vertebrate epidermis" EXACT [] is_a: UBERON:0007376 ! outer epithelial layer is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0007383 ! enveloping layer of ectoderm relationship: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002199 ! integument [Term] id: UBERON:0001004 name: respiratory system def: "Functional system which consists of structures involved in respiration." [] synonym: "apparatus respiratorius" EXACT [] synonym: "apparatus respiratorius " RELATED [] synonym: "Atmungssystem" RELATED [] synonym: "respiratory system" EXACT [] synonym: "systema respiratorium" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001005 name: respiratory airway def: "An airway through which respiratory air passes in organisms." [] is_a: UBERON:0003103 ! compound organ relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0001007 name: digestive system def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [] synonym: "alimentary system" RELATED [] synonym: "alimentary tract" RELATED [] synonym: "gastrointestinal system" RELATED [] synonym: "gut" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001008 name: renal system def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels[GO]." [] synonym: "excretory system" EXACT [] synonym: "renal or urinary system" RELATED [] synonym: "renal system" EXACT [] synonym: "renal/urinary system" RELATED [] synonym: "systema urinaria" EXACT [] synonym: "systema urinarium" EXACT [] synonym: "urinary system" EXACT [] synonym: "urinary tract" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001009 name: circulatory system def: "organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." [] synonym: "systema cardiovasculare" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001013 name: adipose tissue def: "Connective tissue composed of adipocytes." [] synonym: "adipose" RELATED [] synonym: "bodyfat" RELATED [] synonym: "fat" EXACT [] synonym: "fat tissue" EXACT [] synonym: "fatty depot" RELATED [] synonym: "fatty tissue" EXACT [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0001015 name: musculature def: "A subdivision of the muscular system." [] synonym: "muscle group" EXACT [] synonym: "muscle system" RELATED [] synonym: "muscles" RELATED [] synonym: "muscles set" EXACT [] synonym: "musculature" EXACT [] synonym: "musculature system" RELATED [] synonym: "musculi" EXACT [] synonym: "set of muscles" EXACT [] synonym: "set of skeletal muscles" EXACT [] is_a: UBERON:0000480 ! anatomical group relationship: part_of UBERON:0000383 ! musculature of body [Term] id: UBERON:0001016 name: nervous system def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [] synonym: "nerve net" NARROW [] synonym: "Nervensystem" RELATED [] synonym: "systema nervosum" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001017 name: central nervous system def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord[GO]." [] synonym: "basal nucleus of the amygdala" RELATED [] synonym: "basolateral nucleus of amygdala" RELATED [] synonym: "basolateral nucleus of the amygdala" RELATED [] synonym: "cerebrospinal axis" EXACT [] synonym: "CNS" EXACT [] synonym: "neuraxis" EXACT [] synonym: "nucleus amygdalae basalis" RELATED [] synonym: "nucleus amygdaloideus basalis" RELATED [] synonym: "nucleus amygdaloideus basolateralis" RELATED [] synonym: "nucleus basalis amygdalae" RELATED [] synonym: "systema nervosum centrale" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: develops_from UBERON:0000924 ! ectoderm relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0001021 name: nerve def: "an enclosed, cable-like bundle of peripheral axons [wikipedia]. A portion of tissue which is a fasiculated group of axons[ZFA]. Segment of neural tree organ which has as its parts a nerve trunk and its branches; together with other nerves of the same tree it constitutes a neural tree. Examples: chorda tympani, digastric branch of facial nerve, greater petrosal nerve, posterior cutaneous branch of posterior ramus of cervical nerve, superior lateral cutaneous nerve of arm[FMA]." [] synonym: "nerves" EXACT [] synonym: "neural subtree" RELATED [] is_a: UBERON:0000122 ! neuron projection bundle relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0001032 name: sensory system def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [] synonym: "organa sensuum" EXACT [] synonym: "organa sensuum" RELATED [] synonym: "sense organ subsystem" EXACT [] synonym: "sense organs" EXACT [] synonym: "sense organs set" EXACT [] synonym: "sensory organ system" RELATED [] synonym: "sensory subsystem" EXACT [] synonym: "sensory systems" EXACT [] synonym: "set of sense organs" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0004456 ! entire sense organ system [Term] id: UBERON:0001033 name: gustatory system def: "A subset of the sensory system for the sensing of taste." [] synonym: "gustatory organ system" EXACT [] synonym: "taste system" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001040 name: yolk sac def: "Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes." [] synonym: "saccus vitellinus" RELATED [] synonym: "vesicula umbilicalis" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm [Term] id: UBERON:0001041 name: foregut def: "Anterior subdivision of a digestive tract." [] synonym: "praeenteron" RELATED [] synonym: "proenteron" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0001042 name: chordate pharynx def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." [] synonym: "pharynx" BROAD [] is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0006562 ! pharynx relationship: develops_from UBERON:0009145 ! pharyngeal region relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0001043 name: esophagus def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." [] synonym: "gullet" EXACT [] synonym: "oesophagus" EXACT [] synonym: "?sophagus" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0005178 ! thoracic cavity organ is_a: UBERON:0013765 ! digestive system organ relationship: develops_from UBERON:0009143 ! developing esophageal region [Term] id: UBERON:0001044 name: salivary gland def: "saliva-secreting exocrine glands of the oral cavity[GO]. The salivary glands in mammals are exocrine glands, glands with ducts, that produce saliva. They also secrete amylase, an enzyme that breaks down starch into maltose. In other organisms such as insects, salivary glands are often used to produce biologically important proteins like silk or glues, and fly salivary glands contain polytene chromosomes that have been useful in genetic research[WP]." [] synonym: "glandulae salivariae" RELATED [] is_a: UBERON:0003294 ! gland of foregut is_a: UBERON:0010047 ! oral gland relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0001045 name: midgut def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon. That part of the alimentary canal which lies between the gizzard and the hind intestine." [] synonym: "mesenteron" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0001046 name: hindgut def: "Posterior subdivision of a digestive tract[CJM]." [] synonym: "metenteron" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: develops_from UBERON:0003104 ! mesenchyme [Term] id: UBERON:0001048 name: primordium def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt]. An embryonic structure that is the rudiment or commencement of a part or organ." [] synonym: "bud" RELATED [] synonym: "placode" RELATED [] synonym: "rudiment" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0001049 name: neural tube def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." [] synonym: "neural primordium" RELATED [] synonym: "presumptive central nervous system" RELATED [] synonym: "tubus neuralis" RELATED [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007497 ! developing epithelial placode is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0002346 ! neurectoderm relationship: develops_from UBERON:0005068 ! neural rod relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0001052 name: rectum def: "The terminal portion of the intestine." [] synonym: "intestinum rectum" RELATED [] synonym: "rectal sac" RELATED [] synonym: "terminal portion of intestine" EXACT [] synonym: "terminal portion of large intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0006866 ! terminal part of digestive tract relationship: part_of UBERON:0012361 ! internal anal region [Term] id: UBERON:0001054 name: Malpighian tubule def: "The most important structure of the insect's excretory organ, which may comprise cystiform or labyrinthine highly versatile tubules having their outlet into the inital section of the rectum[FBbt]. Any of a group of long blind vessels opening into the posterior part of the alimentary canal in most insects and some other arthropods and functioning primarily as excretory organs[BTO]." [] synonym: "Malphigian tube" RELATED [] synonym: "tuba Malpighii" RELATED [] is_a: UBERON:0009773 ! renal tubule [Term] id: UBERON:0001062 name: anatomical entity def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [] [Term] id: UBERON:0001064 name: ventral pancreatic duct def: "a duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [] synonym: "canal of Wirsung" RELATED [] synonym: "chief pancreatic duct" EXACT [] synonym: "duct of Wirsung" EXACT [] synonym: "ductus pancreatis ventralis" RELATED [] synonym: "hepaticopancreatic duct" RELATED [] synonym: "main pancreatic duct" EXACT [] synonym: "pancreatic duct" BROAD [] is_a: UBERON:0002394 ! bile duct is_a: UBERON:0007329 ! pancreatic duct relationship: develops_from UBERON:0003924 ! ventral pancreatic bud relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: UBERON:0001066 name: intervertebral disk def: "A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core." [] synonym: "discus intervertebralis" EXACT [] synonym: "intervertebral disc" EXACT [] synonym: "intervertebral fibrocartilage" RELATED [] synonym: "spinal disc" EXACT [] synonym: "spinal disk" RELATED [] is_a: UBERON:0011135 ! intervertebral cartilage [Term] id: UBERON:0001081 name: endocardium of ventricle def: "Endocardium that is part of the cardiac ventricle." [] synonym: "cardiac ventricle endocardium" EXACT [] synonym: "endocardium of cardiac ventricle" EXACT [] synonym: "endocardium of heart ventricle" EXACT [] synonym: "endocardium of lower chamber of heart" EXACT [] synonym: "endocardium of ventricle of heart" EXACT [] synonym: "heart ventricle endocardium" EXACT [] synonym: "lower chamber of heart endocardium" EXACT [] synonym: "ventricle endocardial tissue" RELATED [] synonym: "ventricle endocardium" EXACT [] synonym: "ventricle of heart endocardium" EXACT [] synonym: "ventricular endocardium" EXACT [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0002165 ! endocardium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0002165 ! endocardium intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0004784 ! heart ventricle wall [Term] id: UBERON:0001082 name: epicardium of ventricle def: "The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space.[Hu et al. 2001]" [] synonym: "cardiac ventricle epicardium" EXACT [] synonym: "cardiac ventricle heart epicardium" EXACT [] synonym: "cardiac ventricle visceral serous pericardium of heart" EXACT [] synonym: "epicardium of cardiac ventricle" EXACT [] synonym: "epicardium of heart ventricle" EXACT [] synonym: "epicardium of lower chamber of heart" EXACT [] synonym: "epicardium of ventricle of heart" EXACT [] synonym: "heart epicardium of cardiac ventricle" EXACT [] synonym: "heart epicardium of heart ventricle" EXACT [] synonym: "heart epicardium of lower chamber of heart" EXACT [] synonym: "heart epicardium of ventricle of heart" EXACT [] synonym: "heart ventricle epicardium" EXACT [] synonym: "heart ventricle heart epicardium" EXACT [] synonym: "heart ventricle visceral serous pericardium of heart" EXACT [] synonym: "lower chamber of heart epicardium" EXACT [] synonym: "lower chamber of heart heart epicardium" EXACT [] synonym: "lower chamber of heart visceral serous pericardium of heart" EXACT [] synonym: "ventricle of heart epicardium" EXACT [] synonym: "ventricle of heart heart epicardium" EXACT [] synonym: "ventricle of heart visceral serous pericardium of heart" EXACT [] synonym: "ventricular epicardium" EXACT [] synonym: "visceral serous pericardium of heart of cardiac ventricle" EXACT [] synonym: "visceral serous pericardium of heart of heart ventricle" EXACT [] synonym: "visceral serous pericardium of heart of lower chamber of heart" EXACT [] synonym: "visceral serous pericardium of heart of ventricle of heart" EXACT [] is_a: UBERON:0002348 ! epicardium intersection_of: UBERON:0002348 ! epicardium intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0001083 name: myocardium of ventricle def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." [] synonym: "cardiac muscle of cardiac ventricle" EXACT [] synonym: "cardiac muscle of heart ventricle" EXACT [] synonym: "cardiac muscle of lower chamber of heart" EXACT [] synonym: "cardiac muscle of ventricle of heart" EXACT [] synonym: "cardiac ventricle cardiac muscle" EXACT [] synonym: "cardiac ventricle heart muscle" EXACT [] synonym: "cardiac ventricle heart myocardium" EXACT [] synonym: "cardiac ventricle muscle of heart" EXACT [] synonym: "cardiac ventricle myocardium" EXACT [] synonym: "heart muscle of cardiac ventricle" EXACT [] synonym: "heart muscle of heart ventricle" EXACT [] synonym: "heart muscle of lower chamber of heart" EXACT [] synonym: "heart muscle of ventricle of heart" EXACT [] synonym: "heart myocardium of cardiac ventricle" EXACT [] synonym: "heart myocardium of heart ventricle" EXACT [] synonym: "heart myocardium of lower chamber of heart" EXACT [] synonym: "heart myocardium of ventricle of heart" EXACT [] synonym: "heart ventricle cardiac muscle" EXACT [] synonym: "heart ventricle heart muscle" EXACT [] synonym: "heart ventricle heart myocardium" EXACT [] synonym: "heart ventricle muscle of heart" EXACT [] synonym: "heart ventricle myocardium" EXACT [] synonym: "lower chamber of heart cardiac muscle" EXACT [] synonym: "lower chamber of heart heart muscle" EXACT [] synonym: "lower chamber of heart heart myocardium" EXACT [] synonym: "lower chamber of heart muscle of heart" EXACT [] synonym: "lower chamber of heart myocardium" EXACT [] synonym: "muscle of heart of cardiac ventricle" EXACT [] synonym: "muscle of heart of heart ventricle" EXACT [] synonym: "muscle of heart of lower chamber of heart" EXACT [] synonym: "muscle of heart of ventricle of heart" EXACT [] synonym: "myocardium of cardiac ventricle" EXACT [] synonym: "myocardium of heart ventricle" EXACT [] synonym: "myocardium of lower chamber of heart" EXACT [] synonym: "myocardium of ventricle of heart" EXACT [] synonym: "ventricle cardiac muscle" RELATED [] synonym: "ventricle myocardium" EXACT [] synonym: "ventricle of heart cardiac muscle" EXACT [] synonym: "ventricle of heart heart muscle" EXACT [] synonym: "ventricle of heart heart myocardium" EXACT [] synonym: "ventricle of heart muscle of heart" EXACT [] synonym: "ventricle of heart myocardium" EXACT [] synonym: "ventricular myocardium" EXACT [] is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0004784 ! heart ventricle wall [Term] id: UBERON:0001091 name: calcareous tooth def: "Organ with a cavity which consist of dentine surrounded by enamel. Examples: incisor, molar." [] synonym: "dentine containing tooth" EXACT [] synonym: "tooth" EXACT [] synonym: "vertebrate tooth" EXACT [] is_a: UBERON:0003913 ! tooth-like structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0005087 ! tooth placode [Term] id: UBERON:0001096 name: wall of esophagus def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." [] synonym: "anatomical wall of esophagus" EXACT [] synonym: "anatomical wall of gullet" EXACT [] synonym: "anatomical wall of oesophagus" EXACT [] synonym: "esophageal wall" EXACT [] synonym: "esophagus anatomical wall" EXACT [] synonym: "esophagus wall" EXACT [] synonym: "gullet anatomical wall" EXACT [] synonym: "gullet wall" EXACT [] synonym: "oesophagus anatomical wall" EXACT [] synonym: "oesophagus wall" EXACT [] synonym: "wall of gullet" EXACT [] synonym: "wall of oesophagus" EXACT [] is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus [Term] id: UBERON:0001130 name: vertebral column def: "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." [] synonym: "backbone" NARROW [] synonym: "columna vertebralis" RELATED [] synonym: "dorsal spine" RELATED [] synonym: "spinal column" RELATED [] synonym: "spine" BROAD [] synonym: "vertebral column skeleton" NARROW [] synonym: "vertebral region" RELATED [] is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0011138 ! post-cranial axial skeletal system [Term] id: UBERON:0001132 name: parathyroid gland def: "The parathyroid gland is an organ specialised for secretion of parathyroid hormone[GO]. Parathyroid glands control the amount of calcium in the blood and within the bones[WP]." [] synonym: "parathyroid" EXACT [] synonym: "parathyroid secreting cell" RELATED [] is_a: UBERON:0002368 ! endocrine gland relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0001133 name: cardiac muscle tissue def: "Muscle composed of cardiac muscle cells that is part of the heart[ZFA]. involuntary striated muscle found in the walls of the heart, specifically the myocardium[Wikipedia]. Tissue which consists of cardiac myocytes surrounded by cardiac endomysium. Examples: Cardiac muscle tissue proper, conducting tissue of heart[FMA]." [] synonym: "cardiac muscle" EXACT [] synonym: "cardiac muscle muscle tissue" EXACT [] synonym: "cardiac muscle textus muscularis" EXACT [] synonym: "cardiac musculature" RELATED [] synonym: "heart muscle muscle tissue" EXACT [] synonym: "heart muscle textus muscularis" EXACT [] synonym: "heart myocardium muscle tissue" EXACT [] synonym: "heart myocardium textus muscularis" EXACT [] synonym: "muscle of heart muscle tissue" EXACT [] synonym: "muscle of heart textus muscularis" EXACT [] synonym: "muscle tissue of cardiac muscle" EXACT [] synonym: "muscle tissue of heart muscle" EXACT [] synonym: "muscle tissue of heart myocardium" EXACT [] synonym: "muscle tissue of muscle of heart" EXACT [] synonym: "muscle tissue of myocardium" EXACT [] synonym: "myocardium muscle tissue" EXACT [] synonym: "myocardium textus muscularis" EXACT [] synonym: "textus muscularis of cardiac muscle" EXACT [] synonym: "textus muscularis of heart muscle" EXACT [] synonym: "textus muscularis of heart myocardium" EXACT [] synonym: "textus muscularis of muscle of heart" EXACT [] synonym: "textus muscularis of myocardium" EXACT [] is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0001134 name: skeletal muscle tissue def: "Muscle tissue that consists primarily of skeletal muscle fibers." [] synonym: "skeletal muscle" BROAD [] synonym: "skeletal muscle system" RELATED [] synonym: "somatic muscle" RELATED [] is_a: UBERON:0002385 ! muscle tissue relationship: develops_from UBERON:0003082 ! myotome relationship: part_of UBERON:0014892 ! skeletal muscle organ [Term] id: UBERON:0001135 name: smooth muscle tissue def: "Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. Tissue which consists of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Examples: Arrector muscle of hair, Muscularis mucosae." [] synonym: "involuntary muscle" EXACT [] synonym: "non-striated muscle" EXACT [] synonym: "smooth muscle" EXACT [] synonym: "textus muscularis levis; textus muscularis nonstriatus" RELATED [] synonym: "textus muscularis nonstriatus" EXACT [] synonym: "visceral muscle" NARROW [] synonym: "visceral muscle tissue" NARROW [] is_a: UBERON:0002385 ! muscle tissue [Term] id: UBERON:0001136 name: mesothelium def: "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000487 ! simple squamous epithelium intersection_of: develops_from UBERON:0000926 ! mesoderm intersection_of: part_of UBERON:0000042 ! serous membrane relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000042 ! serous membrane [Term] id: UBERON:0001137 name: dorsum def: "The dorsal part of an animal, which in vertebrares includes the vertebral column. [cjm]." [] synonym: "back" EXACT [] synonym: "back of body proper" EXACT [] synonym: "dorsal part of organism" EXACT [] is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0001140 name: renal vein def: "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava." [] synonym: "kidney vein" EXACT [] synonym: "renal venous tree" EXACT [] synonym: "vein of kidney" EXACT [] synonym: "venae renales" RELATED [] is_a: UBERON:0001638 ! vein [Term] id: UBERON:0001153 name: caecum def: "Pouch, connecting the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction." [] synonym: "blind intestine" RELATED [] synonym: "blindgut" RELATED [] synonym: "caeca" NARROW [] synonym: "caecum" EXACT [] synonym: "ceca" NARROW [] synonym: "cecum" EXACT [] synonym: "intestinum caecum" RELATED [] synonym: "intestinum crassum caecum" EXACT [] synonym: "intestinum crassum cecum" RELATED [] is_a: UBERON:0009854 ! digestive tract diverticulum relationship: develops_from UBERON:0001045 ! midgut relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0001154 name: vermiform appendix def: "a blind-ended tube connected to the cecum, from which it develops embryologically[WP]." [] synonym: "apex of cecum" RELATED [] synonym: "appendix" EXACT [] synonym: "appendix vermiformis" EXACT [] synonym: "appendix vermiformis" RELATED [] synonym: "caecal appendix" EXACT [] synonym: "cecal appendix" EXACT [] synonym: "vermix" BROAD [] is_a: UBERON:0013765 ! digestive system organ relationship: develops_from UBERON:0001045 ! midgut relationship: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0004907 ! lower digestive tract [Term] id: UBERON:0001155 name: colon def: "Last portion of the digestive system in most vertebrates; it extracts water and salt from solid wastes before they are eliminated from the body[WP] In mammals, the colon consists of four sections: the ascending colon, the transverse colon, the descending colon, and the sigmoid colon[WP]. In zebrafish, the posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates[ZFIN]." [] synonym: "hindgut" RELATED [] synonym: "large bowel" EXACT [] synonym: "posterior intestine" NARROW [] synonym: "posterior intestine - zebrafish" BROAD [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: part_of UBERON:0000059 ! large intestine [Term] id: UBERON:0001156 name: ascending colon def: "Organ part which is continuous with the cecum proximally and the transverse colon distally.[FMA]" [] synonym: "colon ascendens" EXACT [] synonym: "spiral colon" RELATED [] is_a: UBERON:0000168 ! segment of colon relationship: develops_from UBERON:0001045 ! midgut [Term] id: UBERON:0001157 name: transverse colon def: "The transverse colon the longest and most movable part of the colon, passes with a downward convexity from the right hypochondrium region across the abdomen, opposite the confines of the epigastric and umbilical zones, into the left hypochondrium region, where it curves sharply on itself beneath the lower end of the spleen, forming the splenic or left colic flexure. The right colic flexure is adjacent to the liver. In its course, it describes an arch, the concavity of which is directed backward and a little upward; toward its splenic end there is often an abrupt U-shaped curve which may descend lower than the main curve. It is almost completely invested by peritoneum, and is connected to the inferior border of the pancreas by a large and wide duplicature of that membrane, the transverse mesocolon. It is in relation, by its upper surface, with the liver and gall-bladder, the greater curvature of the stomach, and the lower end of the spleen; by its under surface, with the small intestine; by its anterior surface, with the anterior layers of the greater omentum and the abdominal parietes; its posterior surface is in relation from right to left with the descending portion of the duodenum, the head of the pancreas, and some of the convolutions of the jejunum and ileum. [WP,unvetted]." [] synonym: "colon transversum" EXACT [] is_a: UBERON:0000168 ! segment of colon relationship: develops_from UBERON:0001045 ! midgut [Term] id: UBERON:0001158 name: descending colon def: "The descending colon of humans passes downward through the left hypochondrium and lumbar regions, along the lateral border of the left kidney. At the lower end of the kidney it turns medialward toward the lateral border of the psoas muscle, and then descends, in the angle between psoas and quadratus lumborum, to the crest of the ilium, where it ends in the sigmoid colon. The peritoneum covers its anterior surface and sides, and therefore the descending colon is described as retroperitoneal. (The transverse colon and sigmoid colon, which are immediately proximal and distal, are intraperitoneal). Its posterior surface is connected by areolar tissue with the lower and lateral part of the left kidney, the aponeurotic origin of the transversus abdominis, and the quadratus lumborum. It is smaller in caliber and more deeply placed than the ascending colon. It has a mesentery in 33% of people, and is therefore more frequently covered with peritoneum on its posterior surface than the ascending colon (which has a mesentery in 25% of people). However, it is less likely to undergo volvulus than the ascending colon. In front of it are some coils of small intestine. [WP,unvetted]." [] synonym: "colon descendens" EXACT [] is_a: UBERON:0000168 ! segment of colon relationship: develops_from UBERON:0001046 ! hindgut [Term] id: UBERON:0001159 name: sigmoid colon def: "the part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [] synonym: "colon sigmoideum" RELATED [] synonym: "pelvic colon" RELATED [] synonym: "sigmoid colon" RELATED [] synonym: "sigmoid flexure" RELATED [] is_a: UBERON:0000168 ! segment of colon relationship: develops_from UBERON:0001046 ! hindgut [Term] id: UBERON:0001160 name: fundus of stomach def: "The fundus is the portion of the stomach that lies above the cardiac notch, and contains the fundic glands[GO, Kardong]." [] synonym: "fundus gastricus" RELATED [] synonym: "fundus gastricus (ventricularis)" EXACT [] synonym: "fundus gastricus ventricularis" RELATED [] synonym: "fundus ventricularis" RELATED [] synonym: "fundus ventriculi" RELATED [] synonym: "gastric fundus" EXACT [] synonym: "stomach fundus" EXACT [] is_a: UBERON:0009870 ! zone of stomach [Term] id: UBERON:0001162 name: cardia of stomach def: "The part of the stomach attached to the esophagus. The cardia begins immediately distal to the z-line of the gastroeosphageal junction, where the squamous epithelium of the esophagus gives way to the columnar epithelium of the gastrointestinal tract[WP]" [] synonym: "antrum cardiacum" RELATED [] synonym: "cardiac antrum" RELATED [] synonym: "cardiac orifice" RELATED [] synonym: "cardiac region" RELATED [] synonym: "cardial orifice" RELATED [] synonym: "cardial part of stomach" EXACT [] synonym: "gastric cardia" EXACT [] synonym: "pars cardiaca (gaster)" EXACT [] synonym: "pars cardiaca gastricae" EXACT [] synonym: "stomach cardiac region" EXACT [] is_a: UBERON:0009870 ! zone of stomach [Term] id: UBERON:0001165 name: pyloric antrum def: "Pyloric antrum (antrum, lesser cul-de-sac) is the initial portion of the pyloric part of the stomach. It is near the bottom of the stomach on the left side of the pyloric sphincter, which separates the stomach and the duodenum. It may temporarily become partially or completely shut off from the remainder of the stomach during digestion by peristaltic contraction of the prepyloric sphincter; it is demarcated, sometimes, from the second part of the pyloric part of the stomach by a slight groove. [WP,unvetted]." [] synonym: "antrum" BROAD [] synonym: "antrum of stomach" EXACT [] synonym: "antrum of Willis" RELATED [] synonym: "antrum pylori" RELATED [] synonym: "antrum pyloricum" RELATED [] synonym: "gastric antrum" RELATED [] synonym: "stomach antrum" RELATED [] synonym: "stomach pyloric antrum" EXACT [] is_a: UBERON:0009870 ! zone of stomach relationship: part_of UBERON:0001166 ! pylorus [Term] id: UBERON:0001166 name: pylorus def: "The region of the stomach that connects to the duodenum. It is divided in two parts: the pyloric antrum, which connects to the body of the stomach. the pyloric canal, which connects to the duodenum. The pyloric sphincter, or valve, is a strong ring of smooth muscle at the end of the pyloric canal and lets food pass from the stomach to the duodenum. It receives sympathetic innervation from celiac ganglion. [WP,unvetted]." [] synonym: "pars pylorica" EXACT [] synonym: "pars pylorica gastricae" EXACT [] synonym: "pyloric part of stomach" EXACT [] synonym: "pyloric region" EXACT [] synonym: "stomach pyloric region" EXACT [] synonym: "valvula pylori" RELATED [] is_a: UBERON:0009870 ! zone of stomach [Term] id: UBERON:0001167 name: wall of stomach def: "An anatomical wall that is part of a stomach [Automatically generated definition]." [] synonym: "anatomical wall of stomach" EXACT [] synonym: "anatomical wall of ventriculus" EXACT [] synonym: "gastric wall" EXACT [] synonym: "stomach anatomical wall" EXACT [] synonym: "stomach wall" EXACT [] synonym: "ventriculus anatomical wall" EXACT [] synonym: "ventriculus wall" EXACT [] synonym: "wall of ventriculus" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0009034 ! stomach region intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: UBERON:0001168 name: wall of small intestine def: "An anatomical wall that is part of a small intestine [Automatically generated definition]." [] synonym: "anatomical wall of small bowel" EXACT [] synonym: "anatomical wall of small intestine" EXACT [] synonym: "small bowel anatomical wall" EXACT [] synonym: "small bowel wall" EXACT [] synonym: "small intestinal wall" EXACT [] synonym: "small intestine anatomical wall" EXACT [] synonym: "small intestine wall" EXACT [] synonym: "wall of small bowel" EXACT [] is_a: UBERON:0001262 ! wall of intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001169 name: wall of large intestine def: "An anatomical wall that is part of a large intestine [Automatically generated definition]." [] synonym: "anatomical wall of large intestine" EXACT [] synonym: "large intestinal wall" EXACT [] synonym: "large intestine anatomical wall" EXACT [] synonym: "large intestine wall" EXACT [] is_a: UBERON:0001262 ! wall of intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0001170 name: mesentery of small intestine def: "the peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." [] synonym: "mesentery (proper)" EXACT [] synonym: "mesentery proper" EXACT [] synonym: "small intestinal mesentery" EXACT [] synonym: "small intestine mesentery" EXACT [] is_a: UBERON:0001206 ! serosa of small intestine is_a: UBERON:0004854 ! gastrointestinal system mesentery is_a: UBERON:0007826 ! peritoneal mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001173 name: biliary tree def: "Hollow tree organ, the organ parts of which consists of the bile ducts[FMA]." [] synonym: "biliary tract" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system organ relationship: develops_from UBERON:0004912 ! biliary bud relationship: part_of UBERON:0002294 ! biliary system [Term] id: UBERON:0001178 name: visceral peritoneum def: "The peritoneum that covers the external surfaces of most abdominal organs." [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002358 ! peritoneum [Term] id: UBERON:0001179 name: peritoneal cavity def: "Cavity of serous sac surrounded by the peritoneum.[FMA]" [] synonym: "cavitas peritonealis" RELATED [] synonym: "saccus serosus peritonei" RELATED [] is_a: UBERON:0002323 ! coelemic cavity lumen relationship: develops_from UBERON:0003887 ! intraembryonic coelom relationship: part_of UBERON:0005906 ! serous sac [Term] id: UBERON:0001199 name: mucosa of stomach def: "The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general epithelial lining of the stomach. [WP,unvetted]." [] synonym: "gastric mucosa" EXACT [] synonym: "gastric mucous membrane" EXACT [] synonym: "Magenschleimhaut" RELATED [] synonym: "mucosa of organ of stomach" EXACT [] synonym: "mucosa of organ of ventriculus" EXACT [] synonym: "mucosa of ventriculus" EXACT [] synonym: "mucous membrane of stomach" EXACT [] synonym: "mucous membrane of ventriculus" EXACT [] synonym: "organ mucosa of stomach" EXACT [] synonym: "organ mucosa of ventriculus" EXACT [] synonym: "stomach mucosa" EXACT [] synonym: "stomach mucosa of organ" EXACT [] synonym: "stomach mucous membrane" EXACT [] synonym: "stomach organ mucosa" EXACT [] synonym: "tunica mucosa (gaster)" EXACT [] synonym: "tunica mucosa gastricae" EXACT [] synonym: "tunica mucosa gastris" RELATED [] synonym: "ventriculus mucosa" EXACT [] synonym: "ventriculus mucosa of organ" EXACT [] synonym: "ventriculus mucous membrane" EXACT [] synonym: "ventriculus organ mucosa" EXACT [] is_a: UBERON:0004786 ! gastrointestinal system mucosa is_a: UBERON:0009034 ! stomach region intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001200 name: submucosa of stomach def: "A submucosa that is part of a stomach [Automatically generated definition]." [] synonym: "gastric submucosa" EXACT [] synonym: "stomach submucosa" EXACT [] synonym: "submucosa of ventriculus" EXACT [] synonym: "submucous layer of stomach" RELATED [] synonym: "tela submucosa (gaster)" EXACT [] synonym: "tela submucosa ventriculi" RELATED [] synonym: "ventriculus submucosa" EXACT [] is_a: UBERON:0000009 ! submucosa is_a: UBERON:0009034 ! stomach region intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001201 name: serosa of stomach def: "A serous membrane that is part of a wall of stomach [Automatically generated definition]." [] synonym: "anatomical wall of stomach serosa" EXACT [] synonym: "anatomical wall of stomach serous membrane" EXACT [] synonym: "anatomical wall of ventriculus serosa" EXACT [] synonym: "anatomical wall of ventriculus serous membrane" EXACT [] synonym: "gastric serosa" RELATED [] synonym: "gastric wall serosa" EXACT [] synonym: "gastric wall serous membrane" EXACT [] synonym: "serosa of anatomical wall of stomach" EXACT [] synonym: "serosa of anatomical wall of ventriculus" EXACT [] synonym: "serosa of gastric wall" EXACT [] synonym: "serosa of stomach anatomical wall" EXACT [] synonym: "serosa of stomach wall" EXACT [] synonym: "serosa of ventriculus anatomical wall" EXACT [] synonym: "serosa of ventriculus wall" EXACT [] synonym: "serosa of wall of stomach" EXACT [] synonym: "serosa of wall of ventriculus" EXACT [] synonym: "serous coat of stomach" EXACT [] synonym: "serous membrane of anatomical wall of stomach" EXACT [] synonym: "serous membrane of anatomical wall of ventriculus" EXACT [] synonym: "serous membrane of gastric wall" EXACT [] synonym: "serous membrane of stomach anatomical wall" EXACT [] synonym: "serous membrane of stomach wall" EXACT [] synonym: "serous membrane of ventriculus anatomical wall" EXACT [] synonym: "serous membrane of ventriculus wall" EXACT [] synonym: "serous membrane of wall of stomach" EXACT [] synonym: "serous membrane of wall of ventriculus" EXACT [] synonym: "stomach anatomical wall serosa" EXACT [] synonym: "stomach anatomical wall serous membrane" EXACT [] synonym: "stomach serosa" EXACT [] synonym: "stomach wall serosa" EXACT [] synonym: "stomach wall serous membrane" EXACT [] synonym: "tunica serosa (gaster)" EXACT [] synonym: "tunica serosa gastricae" EXACT [] synonym: "ventriculus anatomical wall serosa" EXACT [] synonym: "ventriculus anatomical wall serous membrane" EXACT [] synonym: "ventriculus wall serosa" EXACT [] synonym: "ventriculus wall serous membrane" EXACT [] synonym: "visceral peritoneum of stomach" EXACT [] synonym: "wall of stomach serosa" EXACT [] synonym: "wall of stomach serous membrane" EXACT [] synonym: "wall of ventriculus serosa" EXACT [] synonym: "wall of ventriculus serous membrane" EXACT [] is_a: UBERON:0004782 ! gastrointestinal system serosa is_a: UBERON:0009034 ! stomach region intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001202 name: pyloric sphincter def: "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." [] synonym: "pyloric valve" EXACT [] is_a: UBERON:0011185 ! gastrointestinal sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus [Term] id: UBERON:0001204 name: mucosa of small intestine def: "A mucosa that is part of a small intestine [Automatically generated definition]." [] synonym: "mucosa of organ of small bowel" EXACT [] synonym: "mucosa of organ of small intestine" EXACT [] synonym: "mucosa of small bowel" EXACT [] synonym: "mucous membrane of small bowel" EXACT [] synonym: "mucous membrane of small intestine" EXACT [] synonym: "organ mucosa of small bowel" EXACT [] synonym: "organ mucosa of small intestine" EXACT [] synonym: "small bowel mucosa" EXACT [] synonym: "small bowel mucosa of organ" EXACT [] synonym: "small bowel mucous membrane" EXACT [] synonym: "small bowel organ mucosa" EXACT [] synonym: "small intestinal mucosa" EXACT [] synonym: "small intestine mucosa" EXACT [] synonym: "small intestine mucosa of organ" EXACT [] synonym: "small intestine mucous membrane" EXACT [] synonym: "small intestine organ mucosa" EXACT [] synonym: "tunica mucosa (intestinum tenue)" EXACT [] synonym: "tunica mucosa intestini tenuis" EXACT [] is_a: UBERON:0001242 ! intestinal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0001242 ! intestinal mucosa relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001205 name: submucosa of small intestine def: "submucosal tissue in the small intestines." [] synonym: "small bowel submucosa" EXACT [] synonym: "small intestinal submucosa" EXACT [] synonym: "small intestine submucosa" EXACT [] synonym: "submucosa of small bowel" EXACT [] synonym: "tela submucosa (intestinum tenue)" EXACT [] synonym: "tela submucosa intestini tenuis" EXACT [] is_a: UBERON:0009566 ! intestinal submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001206 name: serosa of small intestine def: "A serous membrane that is part of a small intestine [Automatically generated definition]." [] synonym: "serosa of small bowel" EXACT [] synonym: "serous coat of small intestine" EXACT [] synonym: "serous membrane of small bowel" EXACT [] synonym: "serous membrane of small intestine" EXACT [] synonym: "small bowel serosa" EXACT [] synonym: "small bowel serous membrane" EXACT [] synonym: "small intestinal serosa" EXACT [] synonym: "small intestine serosa" EXACT [] synonym: "small intestine serous membrane" EXACT [] synonym: "tunica serosa (intestinum tenue)" EXACT [] synonym: "tunica serosa intestini tenuis" EXACT [] synonym: "visceral peritoneum of small intestine" EXACT [] is_a: UBERON:0001243 ! serosa of intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0001243 ! serosa of intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001207 name: mucosa of large intestine def: "A mucosa that is part of a large intestine [Automatically generated definition]." [] synonym: "large intestinal mucosa" EXACT [] synonym: "large intestine mucosa" EXACT [] synonym: "large intestine mucosa of organ" EXACT [] synonym: "large intestine mucous membrane" EXACT [] synonym: "large intestine organ mucosa" EXACT [] synonym: "mucosa of organ of large intestine" EXACT [] synonym: "mucous membrane of large intestine" EXACT [] synonym: "organ mucosa of large intestine" EXACT [] synonym: "tunica mucosa intestini crassi" EXACT [] is_a: UBERON:0001242 ! intestinal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0001208 name: submucosa of large intestine def: "A submucosa that is part of a large intestine [Automatically generated definition]." [] synonym: "large intestinal submucosa" EXACT [] synonym: "large intestine submucosa" EXACT [] synonym: "submucous layer of large intestine" RELATED [] is_a: UBERON:0009566 ! intestinal submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine [Term] id: UBERON:0001209 name: serosa of large intestine def: "A serous membrane that is part of a large intestine [Automatically generated definition]." [] synonym: "large intestinal serosa" EXACT [] synonym: "large intestine serosa" EXACT [] synonym: "large intestine serous membrane" EXACT [] synonym: "serous coat of large intestine" EXACT [] synonym: "serous membrane of large intestine" EXACT [] synonym: "tunica serosa intestini crassi" EXACT [] synonym: "visceral peritoneum of large intestine" EXACT [] is_a: UBERON:0001243 ! serosa of intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine relationship: part_of UBERON:0001243 ! serosa of intestine [Term] id: UBERON:0001211 name: Peyer's patch def: "aggregations of lymphoid tissue that are usually found in the lowest portion of the small intestine ileum in humans; as such, they differentiate the ileum from the duodenum and jejunum // nodular lymphoid structures on the serosal surface of the small intestine." [] synonym: "aggregated lymphoid follicle of intestine" RELATED [] synonym: "aggregated lymphoid nodule" RELATED [] synonym: "noduli lymphoidei aggregati intestini tenuis" EXACT [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue relationship: part_of UBERON:0000030 ! lamina propria relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0001212 name: duodenal gland def: "compound tubular submucosal glands found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." [] synonym: "Brunner's gland" EXACT [] synonym: "gland of Brunner" EXACT [] synonym: "glandula duodenales" RELATED [] synonym: "glandula duodenales Brunneri" RELATED [] synonym: "submucosal gland of duodenum" EXACT [] is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0011148 ! submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0001213 name: intestinal villus def: "Tiny, finger-like projections that protrude from the epithelial lining of the intestinal wall[WP]" [] synonym: "enteric villi" EXACT [] synonym: "enteric villous" EXACT [] synonym: "enteric villus" EXACT [] synonym: "intestinal villi" EXACT [] synonym: "intestinal villus layer" RELATED [] synonym: "small intestine villus" RELATED [] synonym: "villi intestinales" EXACT [] synonym: "villi intestinales" RELATED [] synonym: "villus" EXACT [] synonym: "villus intestinalis (intestinum tenue)" EXACT [] is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0001277 ! intestinal epithelium [Term] id: UBERON:0001224 name: renal pelvis def: "funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]." [] synonym: "kidney pelvis" EXACT [] synonym: "p. renallis" RELATED [] synonym: "pelvis of ureter" EXACT [] synonym: "pyelum" RELATED [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0001225 name: cortex of kidney def: "Region of parenchyma of kidney representing the outer portion.[FMA]" [] synonym: "cortex renalis" EXACT [] synonym: "kidney cortex" EXACT [] synonym: "renal cortex" EXACT [] is_a: UBERON:0001851 ! cortex is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001851 ! cortex intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0008987 ! renal parenchyma [Term] id: UBERON:0001228 name: renal papilla def: "In the kidney, the renal papilla is the location where the Medullary pyramids empty urine into the renal pelvis. Histologically it is marked by medullary collecting ducts converging to channel the fluid. Transitional epithelium begins to be seen. [WP,unvetted]." [] synonym: "kidney papilla" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: UBERON:0001229 name: renal corpuscle def: "In the kidney, a renal corpuscle is the initial blood-filtering component of a nephron. It consists of two structures: a glomerulus and a Bowman's capsule[WP,unvetted]." [] synonym: "corpusculum renale" EXACT [] synonym: "corpusculum renis" RELATED [] synonym: "cortical renal corpuscle" RELATED [] synonym: "kidney corpuscle" RELATED [] synonym: "malphighian corpuscle" RELATED [] synonym: "malphigian corpuscle" EXACT [] synonym: "Malpighian corpuscle" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001285 ! nephron relationship: part_of UBERON:0007684 ! uriniferous tubule [Term] id: UBERON:0001230 name: glomerular capsule def: "The Bowman's capsule is a cup-like sac at the beginning of the tubular component of a nephron in the mammalian kidney. A glomerulus is enclosed in the sac. Fluids from blood in the glomerulus are collected in the Bowman's capsule and further processed along the nephron to form urine. This process is known as ultrafiltration. [WP,unvetted]." [] synonym: "Bowman's capsule" EXACT [] synonym: "bowman's capsule " RELATED [] synonym: "Bowmans capsule" EXACT [] synonym: "capsula glomerularis" EXACT [] synonym: "capsula glomeruli" RELATED [] synonym: "malphigian capsule" RELATED [] synonym: "Mueller capsule" RELATED [] synonym: "Muellerian capsule" RELATED [] synonym: "pronephric glomerular capsule" RELATED [] synonym: "renal glomerular capsule" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0004199 ! S-shaped body relationship: part_of UBERON:0001229 ! renal corpuscle [Term] id: UBERON:0001231 name: nephron tubule def: "An epithelial tube that is part of the nephron, the functional part of the kidney." [] synonym: "kidney tubule" EXACT [] synonym: "renal tubule" BROAD [] synonym: "tubulus renalis" EXACT [] synonym: "uriniferous tubule" RELATED [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0009773 ! renal tubule intersection_of: UBERON:0003914 ! epithelial tube intersection_of: part_of UBERON:0001285 ! nephron relationship: develops_from UBERON:0003918 ! kidney mesenchyme relationship: part_of UBERON:0001285 ! nephron [Term] id: UBERON:0001232 name: collecting duct of renal tubule def: "The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient" [] synonym: "arcuate renal tubule" RELATED [] synonym: "collecting duct" EXACT [] synonym: "collecting duct system" RELATED [] synonym: "collecting tubule" RELATED [] synonym: "junctional tube" RELATED [] synonym: "kidney collecting duct" EXACT [] synonym: "kidney collecting tubule" RELATED [] synonym: "renal collecting tubule" EXACT [] synonym: "tubulus renalis arcuatus" EXACT [] synonym: "tubulus renalis colligens" EXACT [] is_a: UBERON:0006555 ! excretory tube relationship: part_of UBERON:0001285 ! nephron relationship: part_of UBERON:0007684 ! uriniferous tubule [Term] id: UBERON:0001235 name: adrenal cortex def: "Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, including aldosterone and cortisol respectively. It is also a secondary site of androgen synthesis. [WP,unvetted]." [] synonym: "adrenal gland cortex" EXACT [] synonym: "cortex (glandula suprarenalis)" EXACT [] synonym: "cortex glandulae suprarenalis" RELATED [] synonym: "cortex of adrenal gland" EXACT [] synonym: "cortex of suprarenal gland" EXACT [] synonym: "suprarenal" RELATED [] synonym: "suprarenal cortex" EXACT [] is_a: UBERON:0001851 ! cortex is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001851 ! cortex intersection_of: part_of UBERON:0002369 ! adrenal gland relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0002369 ! adrenal gland [Term] id: UBERON:0001236 name: adrenal medulla def: "The adrenal medulla is part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex. It is the innermost part of the adrenal gland, consisting of cells that secrete epinephrine, norepinephrine, and a small amount of dopamine in response to stimulation by sympathetic preganglionic neurons. Composed mainly of hormone-producing chromaffin cells, the adrenal medulla is the principal site of the conversion of the amino acid tyrosine into the catecholamines adrenaline (epinephrine), noradrenaline (norepinephrine), and dopamine[WP,unvetted]." [] synonym: "adrenal central medulla" RELATED [] synonym: "adrenal gland medulla" EXACT [] synonym: "chromaffin cells" RELATED [] synonym: "medulla (glandula suprarenalis)" EXACT [] synonym: "medulla glandulae suprarenalis" EXACT [] synonym: "medulla of adrenal gland" EXACT [] synonym: "medulla of glandula suprarenalis" RELATED [] synonym: "medulla of suprarenal gland" EXACT [] synonym: "suprarenal medulla" EXACT [] is_a: UBERON:0000958 ! medulla is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000958 ! medulla intersection_of: part_of UBERON:0002369 ! adrenal gland relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0002369 ! adrenal gland [Term] id: UBERON:0001237 name: paraaortic body def: "." [] synonym: "organ of zuckerkandl" EXACT [] synonym: "para-aortic body" RELATED [] synonym: "paraganglia of zuckerkandl" RELATED [] synonym: "paraganglion of Zuckerkandl" EXACT [] is_a: UBERON:0000062 ! organ relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0001238 name: lamina propria of small intestine def: "Lamina propria that is part_of the small intestine." [] synonym: "lamina propria mucosa of small bowel" EXACT [] synonym: "lamina propria mucosa of small intestine" EXACT [] synonym: "lamina propria mucosae of small bowel" EXACT [] synonym: "lamina propria mucosae of small intestine" EXACT [] synonym: "lamina propria of mucosa of small intestine" EXACT [] synonym: "lamina propria of small bowel" EXACT [] synonym: "small bowel lamina propria" EXACT [] synonym: "small bowel lamina propria mucosa" EXACT [] synonym: "small bowel lamina propria mucosae" EXACT [] synonym: "small intestine lamina propria" EXACT [] synonym: "small intestine lamina propria mucosa" EXACT [] synonym: "small intestine lamina propria mucosae" EXACT [] is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0001204 ! mucosa of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001241 name: crypt of Lieberkuhn of small intestine def: "A crypt of lieberkuhn that is part of a small intestine [Automatically generated definition]." [] synonym: "crypt of lieberkuhn of small bowel" EXACT [] synonym: "crypt of lieberkuhn of small intestine" EXACT [] synonym: "intestinal gland of small bowel" EXACT [] synonym: "intestinal gland of small intestine" EXACT [] synonym: "lieberkuhn crypt of small bowel" EXACT [] synonym: "lieberkuhn crypt of small intestine" EXACT [] synonym: "small bowel crypt of lieberkuhn" EXACT [] synonym: "small bowel intestinal gland" EXACT [] synonym: "small bowel lieberkuhn crypt" EXACT [] synonym: "small intestinal crypt of Lieberkuhn" EXACT [] synonym: "small intestine crypt of Lieberkuhn" EXACT [] synonym: "small intestine crypt of lieberkuhn" EXACT [] synonym: "small intestine intestinal gland" EXACT [] synonym: "small intestine lieberkuhn crypt" EXACT [] is_a: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001242 name: intestinal mucosa def: "The innermost membrane of the four coats of the intestinal wall, the other three being the submucosa, muscular layers, and serosa. (Berk et al., Gastroenterology, 4th ed, v.3, p1479)" [] synonym: "bowel mucosa" EXACT [] synonym: "bowel mucosa of organ" EXACT [] synonym: "bowel mucous membrane" EXACT [] synonym: "bowel organ mucosa" EXACT [] synonym: "intestine mucosa" EXACT [] synonym: "intestine mucosa of organ" EXACT [] synonym: "intestine mucous membrane" EXACT [] synonym: "intestine organ mucosa" EXACT [] synonym: "mucosa of bowel" EXACT [] synonym: "mucosa of intestine" EXACT [] synonym: "mucosa of organ of bowel" EXACT [] synonym: "mucosa of organ of intestine" EXACT [] synonym: "mucous membrane of bowel" EXACT [] synonym: "mucous membrane of intestine" EXACT [] synonym: "organ mucosa of bowel" EXACT [] synonym: "organ mucosa of intestine" EXACT [] synonym: "tunica mucosa intestini" EXACT [] is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0001243 name: serosa of intestine def: "A serous membrane that is part of a wall of intestine [Automatically generated definition]." [] synonym: "anatomical wall of bowel serosa" EXACT [] synonym: "anatomical wall of bowel serous membrane" EXACT [] synonym: "anatomical wall of intestine serosa" EXACT [] synonym: "anatomical wall of intestine serous membrane" EXACT [] synonym: "bowel anatomical wall serosa" EXACT [] synonym: "bowel anatomical wall serous membrane" EXACT [] synonym: "bowel wall serosa" EXACT [] synonym: "bowel wall serous membrane" EXACT [] synonym: "intestinal serosa" EXACT [] synonym: "intestinal wall serosa" EXACT [] synonym: "intestinal wall serous membrane" EXACT [] synonym: "intestine anatomical wall serosa" EXACT [] synonym: "intestine anatomical wall serous membrane" EXACT [] synonym: "intestine serosa" EXACT [] synonym: "intestine wall serosa" EXACT [] synonym: "intestine wall serous membrane" EXACT [] synonym: "serosa of anatomical wall of bowel" EXACT [] synonym: "serosa of anatomical wall of intestine" EXACT [] synonym: "serosa of bowel anatomical wall" EXACT [] synonym: "serosa of bowel wall" EXACT [] synonym: "serosa of intestinal wall" EXACT [] synonym: "serosa of intestine anatomical wall" EXACT [] synonym: "serosa of intestine wall" EXACT [] synonym: "serosa of wall of bowel" EXACT [] synonym: "serosa of wall of intestine" EXACT [] synonym: "serous membrane of anatomical wall of bowel" EXACT [] synonym: "serous membrane of anatomical wall of intestine" EXACT [] synonym: "serous membrane of bowel anatomical wall" EXACT [] synonym: "serous membrane of bowel wall" EXACT [] synonym: "serous membrane of intestinal wall" EXACT [] synonym: "serous membrane of intestine anatomical wall" EXACT [] synonym: "serous membrane of intestine wall" EXACT [] synonym: "serous membrane of wall of bowel" EXACT [] synonym: "serous membrane of wall of intestine" EXACT [] synonym: "visceral peritoneum of intestine" EXACT [] synonym: "wall of bowel serosa" EXACT [] synonym: "wall of bowel serous membrane" EXACT [] synonym: "wall of intestine serosa" EXACT [] synonym: "wall of intestine serous membrane" EXACT [] is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0001249 name: spleen lymphoid follicle def: "the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [] synonym: "lymphatic follicle of spleen" EXACT [] synonym: "lymphoid follicle of spleen" EXACT [] synonym: "lymphoid nodule of spleen" EXACT [] synonym: "Malpighian body" EXACT [] synonym: "spleen B cell follicle" EXACT [] synonym: "spleen lymphoid follicle" EXACT [] synonym: "spleen lymphoid nodule" RELATED [] synonym: "splenic B cell follicle" EXACT [] synonym: "splenic lymphatic follicle" EXACT [] synonym: "splenic lymphoid follicle" EXACT [] is_a: UBERON:0000444 ! lymphoid follicle is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0001959 ! white pulp of spleen relationship: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0006561 ! non-lymphatic part of lymphoid system relationship: part_of UBERON:1000024 ! parenchyma of spleen [Term] id: UBERON:0001250 name: red pulp of spleen def: "Red pulp of the spleen is composed of connective tissue known as the cords of Billroth and many splenic sinuses that are engorged with blood, giving it a red color. Its primary function is to filter the blood of antigens, microorganisms, and defective or worn-out red blood cells. The spleen is made of red pulp and white pulp, separated by the marginal zone; 76-79% of a normal spleen is red pulp. Unlike white pulp, which mainly contains lymphocytes such as T cells, red pulp is made up of several different types of blood cells, including platelets, granulocytes, red blood cells, and plasma." [] synonym: "pulpa rubra" EXACT [] synonym: "pulpa splenica" RELATED [] synonym: "red pulp" EXACT [] synonym: "spleen red pulp" EXACT [] synonym: "splenic red pulp" EXACT [] is_a: UBERON:1000023 ! spleen pulp [Term] id: UBERON:0001251 name: marginal zone of spleen def: "region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen." [] synonym: "junctional zone of spleen" EXACT [] synonym: "marginal zone" BROAD [] synonym: "spleen marginal zone" EXACT [] is_a: UBERON:0000466 ! immaterial anatomical entity relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0001252 name: adventitia of ureter def: "An adventitia that is part of a ureter." [] synonym: "external adventitia of ureter" EXACT [] synonym: "ureter adventitia" EXACT [] synonym: "ureteral adventitia" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005742 ! adventitia is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0005742 ! adventitia intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0009916 ! wall of ureter [Term] id: UBERON:0001253 name: lamina propria of ureter def: "A lamina propria that is part of a ureter [Automatically generated definition]." [] synonym: "lamina propria mucosa of ureter" EXACT [] synonym: "lamina propria mucosae of ureter" EXACT [] synonym: "ureter lamina propria" EXACT [] synonym: "ureter lamina propria mucosa" EXACT [] synonym: "ureter lamina propria mucosae" EXACT [] is_a: UBERON:0000030 ! lamina propria is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0004980 ! mucosa of ureter relationship: part_of UBERON:0009916 ! wall of ureter [Term] id: UBERON:0001254 name: urothelium of ureter def: "the luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder[MP,unvetted]" [] synonym: "transitional epithelium of ureter" EXACT [] synonym: "ureter luminal urothelium" RELATED [] synonym: "ureter transitional epithelium" EXACT [] synonym: "ureter urothelium" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000365 ! urothelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000365 ! urothelium intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter [Term] id: UBERON:0001255 name: urinary bladder def: "distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." [] synonym: "bladder" EXACT [] synonym: "urocyst" RELATED [] synonym: "vesica" RELATED [] synonym: "vesica urinaria" EXACT [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0002075 ! viscus is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0000164 ! primitive urogenital sinus relationship: part_of UBERON:0001556 ! lower urinary tract [Term] id: UBERON:0001256 name: wall of urinary bladder def: "An anatomical wall that is part of a urinary bladder [Automatically generated definition]." [] synonym: "anatomical wall of bladder" EXACT [] synonym: "anatomical wall of urinary bladder" EXACT [] synonym: "bladder anatomical wall" EXACT [] synonym: "bladder wall" EXACT [] synonym: "urinary bladder anatomical wall" EXACT [] synonym: "urinary bladder wall" EXACT [] synonym: "wall of bladder" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder [Term] id: UBERON:0001257 name: trigone of urinary bladder def: "The trigone is a smooth triangular region of the internal urinary bladder formed by the two ureteral orifices and the internal urethral orifice. The area is very sensitive to expansion and once stretched to a certain degree, the urinary bladder signals the brain of its need to empty. The signals become stronger as the bladder continues to fill. Embryologically, the trigone of the Bladder is derived from the caudal end of mesonephric ducts. In the Female the mesonephric ducts break down but, thus, the Trigone of the Bladder is less prominent but, still present. [WP,unvetted]." [] synonym: "bladder trigone" EXACT [] synonym: "deep trigone" EXACT [] synonym: "Lieutaud's trigone" EXACT [] synonym: "musculus trigoni vesicae profundus" EXACT [] synonym: "trigone of bladder" EXACT [] synonym: "trigonum vesicae" EXACT [] synonym: "trigonum vesicae urinariae" RELATED [] synonym: "urinary bladder trigone" EXACT [] synonym: "vesical trigone" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0006082 ! fundus of urinary bladder [Term] id: UBERON:0001259 name: mucosa of urinary bladder def: "A mucosa that is part of a urinary bladder [Automatically generated definition]." [] synonym: "bladder mucosa" EXACT [] synonym: "bladder mucosa of organ" EXACT [] synonym: "bladder mucous membrane" EXACT [] synonym: "bladder organ mucosa" EXACT [] synonym: "mucosa of bladder" EXACT [] synonym: "mucosa of organ of bladder" EXACT [] synonym: "mucosa of organ of urinary bladder" EXACT [] synonym: "mucous membrane of bladder" EXACT [] synonym: "mucous membrane of urinary bladder" EXACT [] synonym: "organ mucosa of bladder" EXACT [] synonym: "organ mucosa of urinary bladder" EXACT [] synonym: "tunica mucosa (vesica urinaria)" EXACT [] synonym: "tunica mucosa vesicae" EXACT [] synonym: "tunica mucosa vesicae urinariae" EXACT [] synonym: "urinary bladder mucosa" EXACT [] synonym: "urinary bladder mucosa of organ" EXACT [] synonym: "urinary bladder mucous membrane" EXACT [] synonym: "urinary bladder organ mucosa" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 ! wall of urinary bladder [Term] id: UBERON:0001260 name: serosa of urinary bladder def: "A serous membrane that is part of a urinary bladder [Automatically generated definition]." [] synonym: "bladder serosa" EXACT [] synonym: "bladder serous membrane" EXACT [] synonym: "serosa of bladder" EXACT [] synonym: "serous coat of bladder" EXACT [] synonym: "serous coat of urinary bladder" EXACT [] synonym: "serous membrane of bladder" EXACT [] synonym: "serous membrane of urinary bladder" EXACT [] synonym: "tunica serosa (vesica urinaria)" EXACT [] synonym: "tunica serosa vesicae" EXACT [] synonym: "urinary bladder serosa" EXACT [] synonym: "urinary bladder serous membrane" EXACT [] synonym: "visceral peritoneum of urinary bladder" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 ! wall of urinary bladder [Term] id: UBERON:0001261 name: lamina propria of urinary bladder def: "A lamina propria that is part of a urinary bladder [Automatically generated definition]." [] synonym: "bladder lamina propria" EXACT [] synonym: "bladder lamina propria mucosa" EXACT [] synonym: "bladder lamina propria mucosae" EXACT [] synonym: "lamina propria mucosa of bladder" EXACT [] synonym: "lamina propria mucosa of urinary bladder" EXACT [] synonym: "lamina propria mucosae of bladder" EXACT [] synonym: "lamina propria mucosae of urinary bladder" EXACT [] synonym: "lamina propria of bladder" EXACT [] synonym: "urinary bladder lamina propria" EXACT [] synonym: "urinary bladder lamina propria mucosa" EXACT [] synonym: "urinary bladder lamina propria mucosae" EXACT [] is_a: UBERON:0000030 ! lamina propria is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 ! wall of urinary bladder relationship: part_of UBERON:0001259 ! mucosa of urinary bladder [Term] id: UBERON:0001262 name: wall of intestine def: "An anatomical wall that is part of a intestine [Automatically generated definition]." [] synonym: "anatomical wall of bowel" EXACT [] synonym: "anatomical wall of intestine" EXACT [] synonym: "bowel anatomical wall" EXACT [] synonym: "bowel wall" EXACT [] synonym: "bowel wall" RELATED [] synonym: "intestinal wall" EXACT [] synonym: "intestine anatomical wall" EXACT [] synonym: "intestine wall" EXACT [] synonym: "wall of bowel" EXACT [] is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine [Term] id: UBERON:0001263 name: pancreatic acinus def: "the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." [] synonym: "acinus pancreaticus" EXACT [] synonym: "pancreas acinus" EXACT [] synonym: "pancreatic acinar" RELATED [] synonym: "pancreatic acini" RELATED [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009842 ! acinus intersection_of: UBERON:0009842 ! acinus intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0007324 ! pancreatic lobe [Term] id: UBERON:0001264 name: pancreas def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 12% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID]." [] is_a: UBERON:0002075 ! viscus relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0001266 name: splenic cord def: "A structure found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. These cords contain half of the human body's monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing. Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis." [] synonym: "cord of Billroth" EXACT [] synonym: "cord of Bilroth" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001250 ! red pulp of spleen [Term] id: UBERON:0001276 name: epithelium of stomach def: "the epithelial layer of the stomach ." [] synonym: "epithelial tissue of stomach" EXACT [] synonym: "epithelial tissue of ventriculus" EXACT [] synonym: "epithelium of ventriculus" EXACT [] synonym: "gastric epithelium" RELATED [] synonym: "stomach epithelial tissue" EXACT [] synonym: "stomach epithelium" EXACT [] synonym: "ventriculus epithelial tissue" EXACT [] synonym: "ventriculus epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0004808 ! gastrointestinal system epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001199 ! mucosa of stomach [Term] id: UBERON:0001277 name: intestinal epithelium def: "The innermost membrane of the four coats of the intestinal wall, the other three being the submucosa, muscular layers, and serosa. (Berk et al., Gastroenterology, 4th ed, v.3, p1479)" [] synonym: "bowel epithelial tissue" EXACT [] synonym: "bowel epithelium" EXACT [] synonym: "epithelial tissue of bowel" EXACT [] synonym: "epithelial tissue of intestine" EXACT [] synonym: "epithelium of bowel" EXACT [] synonym: "epithelium of intestine" EXACT [] synonym: "intestine epithelial tissue" EXACT [] synonym: "intestine epithelium" RELATED [] synonym: "villous epithelium" NARROW [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0004808 ! gastrointestinal system epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0001278 name: epithelium of large intestine def: "An epithelium that is part of a large intestine [Automatically generated definition]." [] synonym: "epithelial tissue of large intestine" EXACT [] synonym: "large intestinal epithelium" EXACT [] synonym: "large intestine epithelial tissue" EXACT [] synonym: "large intestine epithelium" EXACT [] is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001207 ! mucosa of large intestine [Term] id: UBERON:0001280 name: liver parenchyma def: "the functional units of the liver including the lobules." [] synonym: "hepatic parenchyma" EXACT [] synonym: "hepatic parenchyme" RELATED [] synonym: "liver parenchyme" EXACT [] synonym: "parenchyma of liver" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002107 ! liver relationship: develops_from UBERON:0005171 ! hepatic duct relationship: develops_from UBERON:0008835 ! hepatic diverticulum relationship: part_of UBERON:0002107 ! liver [Term] id: UBERON:0001281 name: hepatic sinusoid def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." [] synonym: "hepatic sinusoids" RELATED [] synonym: "liver sinusoid" EXACT [] synonym: "liver sinusoidal blood vessel" EXACT [] synonym: "sinusoid of liver" EXACT [] synonym: "sinusoidal blood vessel of liver" EXACT [] synonym: "vas capillare sinusoideum" EXACT [] synonym: "vas sinusoideum" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0003909 ! sinusoid is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0003909 ! sinusoid intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0004647 ! liver lobule relationship: part_of UBERON:0006877 ! vasculature of liver [Term] id: UBERON:0001285 name: nephron def: "The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]" [] synonym: "mature nephron" NARROW [] synonym: "nephroneum" RELATED [] synonym: "tubulus renalis" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0004208 ! nephrogenic mesenchyme relationship: part_of UBERON:0007684 ! uriniferous tubule [Term] id: UBERON:0001287 name: proximal convoluted tubule def: "The proximal tubule is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle[WP]" [] synonym: "1st convoluted tubule" RELATED [] synonym: "first convoluted tubule" RELATED [] synonym: "PCT" RELATED [] synonym: "proximal convoluted renal tubule" EXACT [] synonym: "tubulus contortus proximalis" EXACT [] synonym: "tubulus contortus proximalis" RELATED [] synonym: "tubulus convolutus proximalis" RELATED [] is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0006534 ! renal convoluted tubule is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0001288 name: loop of Henle def: "Portion of the nephron that leads from the proximal convoluted tubule to the distal convoluted tubule. The loop has a hairpin bend in the renal medulla. The main function of this structure is to create a concentration gradient in the medulla of the kidney. By means of a countercurrent multiplier system, which utilizes sodium pumps, it creates an area of high sodium concentration deep in the medulla, near the collecting duct. Water present in the filtrate in the collecting duct flows through aquaporin channels out of the collecting duct, moving passively down its concentration gradient. This process reabsorbs water and creates a concentrated urine for excretion[WP]." [] synonym: "ansa nephroni" EXACT [] synonym: "Henle loop" EXACT [] synonym: "henle's loop" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0001289 name: descending limb of loop of Henle def: "Portion of the renal tubule constituting the first part of the loop of Henle[WP]." [] synonym: "descending limb" BROAD [] synonym: "descending limb of Henle's loop" EXACT [] synonym: "loop of Henle descending limb" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule relationship: part_of UBERON:0001288 ! loop of Henle [Term] id: UBERON:0001290 name: proximal straight tubule def: "part of the descending limb of the renal tubule, extending from the proximal convoluted tubule to the thin tubule[BTO]." [] synonym: "pars recta" RELATED [] synonym: "pars recta tubuli renalis" RELATED [] synonym: "proximal tubule segment 3" RELATED [] synonym: "S3" EXACT [] synonym: "segment 3 of proximal tubule" RELATED [] synonym: "thick descending limb of proximal tubule" EXACT [] synonym: "tubulus rectus proximalis" EXACT [] is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0008404 ! proximale tubular epithelium relationship: part_of UBERON:0001289 ! descending limb of loop of Henle relationship: part_of UBERON:0004134 ! proximal tubule relationship: part_of UBERON:0006542 ! outer medulla outer stripe loop of henle [Term] id: UBERON:0001291 name: thick ascending limb of loop of Henle def: "a segment of the nephron in the kidney. It can be divided into two parts: that in the renal medulla, and that in the renal cortex[Wikipedia:Thick_ascending_limb_of_loop_of_Henle]." [] synonym: "ascending thick limb" EXACT [] synonym: "distal straight tubule" EXACT [] synonym: "loop of Henle ascending limb thick segment" EXACT [] synonym: "straight portion of distal convoluted renal tubule" EXACT [] synonym: "straight portion of distal convoluted tubule" EXACT [] synonym: "thick ascending limb" EXACT [] synonym: "thick ascending limb of distal tubule" EXACT [] synonym: "thick ascending limb of Henle's loop" EXACT [] synonym: "tubulus rectus distalis" EXACT [] synonym: "tubulus rectus distalis" RELATED [] is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0008408 ! distal tubular epithelium relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle [Term] id: UBERON:0001292 name: distal convoluted tubule def: "a portion of kidney nephron between the loop of Henle and the collecting duct system." [] synonym: "distal convoluted renal tubule" EXACT [] synonym: "second convoluted tubule" RELATED [] synonym: "tubulus contortus distalis" EXACT [] synonym: "tubulus contortus distalis" RELATED [] synonym: "tubulus convolutus distalis" RELATED [] is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0006534 ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0001293 name: outer medulla of kidney def: "The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla[GO]." [] synonym: "kidney outer medulla" RELATED [] synonym: "outer renal medulla" EXACT [] synonym: "outer zone of medulla of kidney" EXACT [] synonym: "outer zone of renal medulla" EXACT [] synonym: "renal outer medulla" EXACT [] synonym: "set of outer region of renal pyramids" RELATED [] synonym: "zona externa (medullaris renalis)" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0001294 name: inner medulla of kidney def: "Innermost region of the mammalian kidney." [] synonym: "inner renal medulla" EXACT [] synonym: "inner zone of medulla of kidney" EXACT [] synonym: "inner zone of renal medulla" EXACT [] synonym: "kidney inner medulla" RELATED [] synonym: "renal inner medulla" EXACT [] synonym: "set of inner region of renal pyramids" EXACT [] synonym: "zona interna (medullaris renalis)" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0001295 name: endometrium def: "inner mucous membrane of the mammalian uterus." [] synonym: "tunica mucosa (endometrium)" EXACT [] synonym: "tunica mucosa uteri" EXACT [] synonym: "uterine endometrium" EXACT [] synonym: "uterine mucous membrane" RELATED [] is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0000459 ! uterine wall [Term] id: UBERON:0001296 name: myometrium def: "middle layer of the uterine wall consisting of smooth muscle cells and supporting stromal and vascular tissue." [] synonym: "tunica muscularis" RELATED [] synonym: "tunica muscularis (myometrium)" EXACT [] synonym: "uterine myometrium" RELATED [] synonym: "uterine smooth muscle" RELATED [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0000459 ! uterine wall [Term] id: UBERON:0001297 name: serosa of uterus def: "Outer serosa layer of the uterus." [] synonym: "perimetrium" EXACT [] synonym: "serous coat of uterus" EXACT [] synonym: "serous membrane of uterus" EXACT [] synonym: "tunica serosa (perimetrium)" EXACT [] synonym: "tunica serosa uteri" EXACT [] synonym: "uterine serosa" EXACT [] synonym: "uterus serosa" EXACT [] synonym: "uterus serous membrane" EXACT [] synonym: "visceral peritoneum of uterus" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000459 ! uterine wall relationship: part_of UBERON:0000995 ! uterus [Term] id: UBERON:0001301 name: epididymis def: "A narrow, tightly-coiled tube connecting the efferent ducts from the rear of each testicle to its vas deferens." [] synonym: "epididymus" EXACT [] synonym: "Nebenhoden@ge" RELATED [] is_a: UBERON:0005904 ! duct of male reproductive system relationship: develops_from UBERON:0003074 ! mesonephric duct relationship: part_of UBERON:0006947 ! male genital duct [Term] id: UBERON:0001305 name: ovarian follicle def: "Ovarian follicles are the basic units of female reproductive biology, each of which is composed of roughly spherical aggregations of cells found in the ovary. They contain a single oocyte (aka ovum or egg). These structures are periodically initiated to grow and develop, culminating in ovulation of usually a single competent oocyte in humans. These eggs/ova are only developed once every menstrual cycle (e.g. once a month in humans)[WP]." [] synonym: "egg follicle" RELATED [] synonym: "follicle of ovary" EXACT [] synonym: "follicle of ovary viewed macroscopically" EXACT [] synonym: "folliculi ovarici primarii" RELATED [] synonym: "folliculi ovarici vesiculosi" RELATED [] synonym: "ovary follicle" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: develops_from UBERON:0005296 ! ovary sex cord relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0001310 name: umbilical artery def: "The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]." [] synonym: "a. umbilicalis" RELATED [] is_a: UBERON:0001637 ! artery is_a: UBERON:0010260 ! umbilical blood vessel [Term] id: UBERON:0001319 name: vaginal vein def: "The vaginal plexuses are placed at the sides of the vagina; they communicate with the uterine, vesical, and hemorrhoidal plexuses, and are drained by the vaginal veins, one on either side, into the hypogastric veins. [WP,unvetted]." [] synonym: "vagina vein" EXACT [] synonym: "vein of vagina" EXACT [] is_a: UBERON:0001638 ! vein is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0001325 name: muscle of pelvis def: "Muscle (organ) which is a part of the pelvis. Examples: levator ani," [] synonym: "muscle organ of pelvis" EXACT [] synonym: "pelvic muscle" EXACT [] synonym: "pelvis muscle" EXACT [] synonym: "pelvis muscle organ" EXACT [] is_a: UBERON:0003833 ! abdominal segment muscle is_a: UBERON:0005179 ! pelvic region organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0002355 ! pelvis relationship: part_of UBERON:0002355 ! pelvis [Term] id: UBERON:0001332 name: prepuce of penis def: "In male human anatomy, the foreskin is a retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect. It is also described as the prepuce, a technically broader term that also includes the clitoral hood in women, to which the foreskin is embryonically homologous. [WP,unvetted]." [] synonym: "foreskin" RELATED [] synonym: "penile prepuce" EXACT [] synonym: "praeputium" RELATED [] synonym: "prepuce" BROAD [] synonym: "prepuce of male" EXACT [] synonym: "prepucium" RELATED [] synonym: "preputium" BROAD [] is_a: UBERON:0011374 ! prepuce is_a: UBERON:0014403 ! male anatomical structure relationship: develops_from UBERON:0004876 ! urogenital ridge relationship: part_of UBERON:0000989 ! penis [Term] id: UBERON:0001333 name: male urethra def: "In anatomy, the urethra (from Greek ??????? - ourethra) is a tube which connects the urinary bladder to the outside of the body. The urethra has an excretory function in both sexes to pass urine to the outside, and also a reproductive function in the male, as a passage for semen. The external urethral sphincter is a striated muscle that allows voluntary control over urination. [WP,unvetted]." [] is_a: UBERON:0000057 ! urethra is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000057 ! urethra intersection_of: part_of UBERON:0003101 ! male organism relationship: develops_from UBERON:0013241 ! embryonic urethral groove relationship: part_of UBERON:0003101 ! male organism [Term] id: UBERON:0001334 name: female urethra def: "In anatomy, the urethra (from Greek ??????? - ourethra) is a tube which connects the urinary bladder to the outside of the body. The urethra has an excretory function in both sexes to pass urine to the outside, and also a reproductive function in the male, as a passage for semen. The external urethral sphincter is a striated muscle that allows voluntary control over urination. [WP,unvetted]." [] synonym: "urethra feminina" RELATED [] synonym: "urethra muliebris" RELATED [] is_a: UBERON:0000057 ! urethra is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000057 ! urethra intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0003100 ! female organism [Term] id: UBERON:0001338 name: urethral gland def: "any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine" [] synonym: "gland of urethra" EXACT [] synonym: "urethra gland" EXACT [] synonym: "urethra gland (male or female)" EXACT [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0001343 name: seminiferous tubule of testis def: "Seminiferous tubules are located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. The epithelium of the tubule consists of sustentacular or Sertoli cells, which are tall, columnar type cells that line the tubule. In between the Sertoli cells are spermatogenic cells, which differentiate through meiosis to sperm cells. There are two types: convoluted and straight. convuluted towards the lateral side and straight as the tubule comes medially to form ducts which will exit the testis. [WP,unvetted]." [] synonym: "seminiferous cord" EXACT [] synonym: "seminiferous tubule" EXACT [] synonym: "testis - seminiferous tubule" EXACT [] synonym: "tubuli seminiferi" EXACT [] synonym: "tubuli seminiferi" RELATED [] is_a: UBERON:0005904 ! duct of male reproductive system relationship: develops_from UBERON:0005297 ! testis sex cord relationship: part_of UBERON:0000473 ! testis [Term] id: UBERON:0001344 name: epithelium of vagina def: "the epithelial layer of the vagina." [] synonym: "epithelial tissue of vagina" EXACT [] synonym: "epithelium, vaginal" RELATED [] synonym: "vagina epithelial tissue" EXACT [] synonym: "vagina epithelium" EXACT [] synonym: "vaginal epithelium" EXACT [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0004804 ! oviduct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0001347 name: white adipose tissue def: "Connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels[MP,modified]" [] synonym: "adipocytus unigutturalis" EXACT [] synonym: "textus adiposus albus" EXACT [] synonym: "textus adiposus albus" RELATED [] synonym: "unilocular adipose tissue" EXACT [] synonym: "white fat" EXACT [] is_a: UBERON:0001013 ! adipose tissue [Term] id: UBERON:0001348 name: brown adipose tissue def: "A thermogenic form of adipose tissue that is composed of brown adipocytes[MP,modified]" [] synonym: "adipocytus multigutturalis" EXACT [] synonym: "brown fat" EXACT [] synonym: "multilocular adipose tissue" EXACT [] synonym: "textus adiposus fuscus" EXACT [] synonym: "textus adiposus fuscus" RELATED [] is_a: UBERON:0001013 ! adipose tissue [Term] id: UBERON:0001351 name: lacrimal sac def: "The lacrimal sac is the upper dilated end of the nasolacrimal duct, and is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla. It connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity. This is mainly for high amounts of tears, in which the lacrimal sac pumps inward and outward driven by the orbicularis muscle during blinking. It is oval in form and measures from 12 to 15 mm. in length; its upper end is closed and rounded; its lower is continued into the nasolacrimal duct. Its superficial surface is covered by a fibrous expansion derived from the medial palpebral ligament, and its deep surface is crossed by the lacrimal part of the Orbicularis oculi, which is attached to the crest on the lacrimal bone. Like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, with surrounding connective tissue. [WP,unvetted]." [] synonym: "saccus lacrimalis" RELATED [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001850 ! lacrimal duct [Term] id: UBERON:0001352 name: external acoustic meatus def: "A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter." [] synonym: "auditory canal" EXACT [] synonym: "auditory meatus" RELATED [] synonym: "ear canal" EXACT [] synonym: "external acoustic tube" EXACT [] synonym: "external auditory canal" EXACT [] synonym: "external auditory meatus" RELATED [] synonym: "external auditory tube" EXACT [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0005872 ! 1st arch pharyngeal cleft relationship: part_of UBERON:0001691 ! external ear [Term] id: UBERON:0001353 name: anal region def: "The anus and surrounding regions. Encompasses both internal and external regions, where present" [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0001366 name: parietal peritoneum def: "The peritoneum that lines the walls of the peritoneal cavity." [] synonym: "peritoneal cavity lining" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002358 ! peritoneum [Term] id: UBERON:0001422 name: facial lymphatic vessel def: "A lymphatic vessel that is part of a face [Automatically generated definition]." [] synonym: "buccal lymphatic vessel" EXACT [] synonym: "face lymph vessel" EXACT [] synonym: "face lymphatic vessel" EXACT [] synonym: "FL" RELATED [] synonym: "lymph vessel of face" EXACT [] synonym: "lymphatic vessel of face" EXACT [] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: part_of UBERON:0001456 ! face relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0001434 name: skeletal system def: "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." [] synonym: "set of all bones and joints" NARROW [] synonym: "skeleton system" EXACT [] synonym: "Skelettsystem" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] id: UBERON:0001443 name: chest def: "Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA]." [] synonym: "anterior chest" EXACT [] synonym: "anterior thoracic region" EXACT [] synonym: "anterolateral part of thorax" EXACT [] synonym: "front of chest" EXACT [] synonym: "front of thorax" EXACT [] synonym: "pectus" EXACT [] synonym: "thoracic body wall" RELATED [] synonym: "thorax" RELATED [] synonym: "ventral part of thoracic region" EXACT [] is_a: UBERON:0009569 ! subdivision of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0001444 name: subdivision of head synonym: "head region" EXACT [] synonym: "head subdivision" EXACT [] synonym: "region of head" EXACT [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0001456 name: face def: "Subdivision of head which consists of the facial skeleton and all layers superficial to it[FMA,modified]." [] synonym: "facia/facies" RELATED [] synonym: "visage" RELATED [] is_a: UBERON:0001444 ! subdivision of head [Term] id: UBERON:0001468 name: intervertebral joint def: "The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments." [] synonym: "inter-centrum joint" EXACT [] synonym: "inter-vertebral joint" EXACT [] synonym: "intervertebral symphysis" EXACT [] synonym: "joint of vertebral body" EXACT [] synonym: "vertebral joint" BROAD [] is_a: UBERON:0002216 ! symphysis is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0001473 name: lymphatic vessel def: "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." [] synonym: "lymph vessel" EXACT [] synonym: "vas lymphaticum" RELATED [] is_a: UBERON:0000055 ! vessel relationship: part_of UBERON:0004536 ! lymph vasculature relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system [Term] id: UBERON:0001474 name: bone element def: "Skeletal element that is composed of bone tissue." [] synonym: "bone" RELATED [] synonym: "bone element" EXACT [] synonym: "bone organ" EXACT [] is_a: UBERON:0004765 ! skeletal element relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0001515 name: thoracic aorta def: "The thoracic aorta is contained in the posterior mediastinal cavity. It begins at the lower border of the fourth thoracic vertebra where it is continuous with the aortic arch, and ends in front of the lower border of the twelfth thoracic vertebra, at the aortic hiatus in the diaphragm where it becomes the abdominal aorta. At its commencement, it is situated on the left of the vertebral column; it approaches the median line as it descends; and, at its termination, lies directly in front of the column. The vessel describes a curve which is concave forward; as the branches given off from it are small, its diminution in size is insignificant. It has a radius of approximately 1.16 cm. [WP,unvetted]." [] synonym: "aorta thoracalis" RELATED [] synonym: "pars thoracica aortae" RELATED [] synonym: "thoracic part of aorta" EXACT [] is_a: UBERON:0005800 ! segment of aorta intersection_of: UBERON:0005800 ! segment of aorta intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0001529 name: brachiocephalic artery def: "The brachiocephalic artery (or brachiocephalic trunk or innominate artery) is an artery of the mediastinum that supplies blood to the right arm and the head and neck. It is the first branch of the aortic arch, and soon after it emerges, the brachiocephalic artery divides into the right common carotid artery and the right subclavian artery. There is no brachiocephalic artery for the left side of the body. The left common carotid, and the left subclavian artery, come directly off the aortic arch. However, there are two brachiocephalic veins. [WP,unvetted]." [] synonym: "brachiocephalic trunk" EXACT [] synonym: "innominate" BROAD [] synonym: "innominate artery" EXACT [] synonym: "truncus brachiocephalicus" EXACT [] synonym: "truncus brachiocephalicus" RELATED [] is_a: UBERON:0004573 ! systemic artery relationship: part_of UBERON:0007204 ! brachiocephalic vasculature [Term] id: UBERON:0001533 name: subclavian artery def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta" [] synonym: "arteria subclavia" EXACT [] synonym: "arteria subclavia" RELATED [] synonym: "arterial tree of upper limb" EXACT [] synonym: "PA" RELATED [] synonym: "pectoral artery" EXACT [] synonym: "subclavian arterial tree" EXACT [] is_a: UBERON:0004573 ! systemic artery relationship: develops_from UBERON:0002457 ! intersomitic artery [Term] id: UBERON:0001552 name: arcuate artery def: "One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries." [] synonym: "kidney arcuate artery" EXACT [] is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0001555 name: digestive tract def: "Tube extending from the mouth to the anus." [] synonym: "alimentary canal" NARROW [] synonym: "alimentary tract" NARROW [] synonym: "digestive canal" RELATED [] synonym: "digestive tube" EXACT [] synonym: "enteric tract" EXACT [] synonym: "gut" BROAD [] synonym: "gut tube" RELATED [] is_a: UBERON:0000025 ! tube relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0001556 name: lower urinary tract def: "Subdivision of urinary system which consists of the urinary bladder and the urethra." [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0001557 name: upper respiratory tract def: "Subdivision of respiratory system which consists of the nose, nasopharynx, oropharynx and larynx[FMA]" [] is_a: UBERON:0000072 ! segment of respiratory tract [Term] id: UBERON:0001558 name: lower respiratory tract def: "The segment of respiratory tract from the trachea to the lungs[WP,modified]" [] is_a: UBERON:0000072 ! segment of respiratory tract [Term] id: UBERON:0001560 name: neck of organ synonym: "organ neck" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001575 name: extrinsic muscle of tongue def: "A muscle organ that attaches the tongue to some other structure." [] synonym: "extrinsic lingual muscle" EXACT [] synonym: "extrinsic tongue muscle" EXACT [] is_a: UBERON:0001576 ! intrinsic muscle of tongue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0011332 ! extrinsic tongue pre-muscle mass relationship: part_of UBERON:0003273 ! skeletal muscle tissue of tongue [Term] id: UBERON:0001576 name: intrinsic muscle of tongue def: "The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII." [] synonym: "intrinsic lingual muscle" EXACT [] synonym: "intrinsic tongue muscle" EXACT [] is_a: UBERON:0000378 ! tongue muscle relationship: develops_from UBERON:0010059 ! hypoglossal cord relationship: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0003273 ! skeletal muscle tissue of tongue [Term] id: UBERON:0001577 name: facial nerve muscle def: "The facial muscles are a group of striated muscles innervated by the facial nerve that, among other things, control facial expression. These muscles are also called mimetic muscles. [WP,unvetted]." [] synonym: "cranial/facial muscle" RELATED [] synonym: "face muscle" EXACT [] synonym: "face muscle organ" EXACT [] synonym: "facial muscle" EXACT [] synonym: "facial nerve innervated muscle" EXACT [] synonym: "mimetic muscles" RELATED [] synonym: "muscle of face" EXACT [] synonym: "muscle of facial expression" RELATED [] synonym: "muscle organ of face" EXACT [] synonym: "muscles of facial expression" RELATED [] synonym: "musculi faciei" RELATED [] is_a: UBERON:0002376 ! muscle of head is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003066 ! pharyngeal arch 2 relationship: part_of UBERON:0004473 ! musculature of face [Term] id: UBERON:0001606 name: muscle of iris def: "." [] synonym: "iris muscle" EXACT [] synonym: "iris muscle organ" EXACT [] synonym: "muscle organ of iris" EXACT [] is_a: UBERON:0011222 ! intra-ocular muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0001607 name: sphincter pupillae def: "The iris sphincter muscle (pupillary sphincter, circular muscle of iris, circular fibers) is a muscle in the part of the eye called the iris. It encircles the eye, appropriate to its function as a constrictor. It is found in vertebrates and some cephalopods. In humans, it functions to constrict the pupil in bright light or during accommodation. Its dimensions are about 0.75 mm wide by 0.15 mm thick. It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves. Initially, all the myocytes are of the smooth muscle type, but much later in life, so that ultimately most cells are of the striated muscle type. [WP,unvetted]." [] synonym: "circular fibers" RELATED [] synonym: "constrictor pupillae" RELATED [] synonym: "iris constrictor" RELATED [] synonym: "iris constrictor muscle" RELATED [] synonym: "iris sphincter" RELATED [] synonym: "iris sphincter muscle" EXACT [] synonym: "M. sphincter pupillae" EXACT [] synonym: "m. sphincter pupillae" RELATED [] synonym: "musculus sphincter pupillae" EXACT [] synonym: "pupillary constrictor muscle" RELATED [] synonym: "pupillary sphincter" RELATED [] synonym: "pupillary sphincter muscle" RELATED [] synonym: "sphincter muscle of pupil" EXACT [] synonym: "sphincter pupillae" RELATED [] synonym: "sphincter pupillae muscle" RELATED [] synonym: "spincter pupillae" RELATED [] is_a: UBERON:0001606 ! muscle of iris is_a: UBERON:0004234 ! iris smooth muscle is_a: UBERON:0007521 ! smooth muscle sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0001608 name: dilatator pupillae def: "The iris dilator muscle (pupil dilator muscle, pupillary dilator, radial muscle of iris, radiating fibers), is a smooth muscle of the eye, running radially in the iris and therefore fit as a dilator. It is innervated by the sympathetic system, which acts by releasing noradrenaline, which acts on ?1-receptors. Thus, when presented with a threatening stimuli that activates the fight-or-flight response, this innervation dilates the iris, thus temporarily letting more light reach the retina. [WP,unvetted]." [] synonym: "dilator muscle of pupil" EXACT [] synonym: "dilator of pupil" EXACT [] synonym: "dilator pupillae" EXACT [] synonym: "dilator pupillae muscle" EXACT [] synonym: "dilator pupillae muscle" RELATED [] synonym: "iris dilator" RELATED [] synonym: "iris dilator muscle" EXACT [] synonym: "musculus dilatator pupillae" EXACT [] synonym: "musculus dilatator pupillae" RELATED [] synonym: "musculus dilator pupillae" RELATED [] synonym: "pupil dilator" RELATED [] synonym: "pupil dilator muscle" RELATED [] synonym: "pupillary dilator" RELATED [] synonym: "pupillary dilator muscle" EXACT [] synonym: "pupillary muscle" RELATED [] synonym: "radial muscle" RELATED [] synonym: "radial muscle of iris" EXACT [] synonym: "radiating fibers" RELATED [] is_a: UBERON:0004234 ! iris smooth muscle [Term] id: UBERON:0001621 name: coronary artery def: "An artery that supplies the myocardium." [] synonym: "coronary arterial tree" EXACT [] is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0004573 ! systemic artery relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0001630 name: muscle organ def: "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. Nonparenchymatous organ that primarily consists of skeletal muscle tissue aggregated into macroscopic fasciculi by connective tissue; together with other muscles, it constitutes the muscular system. Examples: biceps, diaphragm, masseter, right third external intercostal muscle, external oblique, levator ani, serratus anterior[FMA]." [] synonym: "muscle" BROAD [] is_a: UBERON:0000062 ! organ is_a: UBERON:0005090 ! muscle structure relationship: part_of UBERON:0001015 ! musculature [Term] id: UBERON:0001637 name: artery def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." [] synonym: "arterial subtree" EXACT [] synonym: "arterial system" RELATED [] synonym: "arterial tree organ part" EXACT [] synonym: "arterial vessel" RELATED [] synonym: "arteries" EXACT [] is_a: UBERON:0003509 ! arterial blood vessel relationship: part_of UBERON:0004572 ! arterial system [Term] id: UBERON:0001638 name: vein def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." [] synonym: "vascular element" RELATED [] synonym: "vena" RELATED [] synonym: "venae" RELATED [] synonym: "venous subtree" BROAD [] synonym: "venous tree organ part" EXACT [] synonym: "venous vessel" BROAD [] is_a: UBERON:0003920 ! venous blood vessel [Term] id: UBERON:0001647 name: facial nerve def: "Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches)." [] synonym: "7n" BROAD [] synonym: "branchiomeric cranial nerve" EXACT [] synonym: "CN-VII" RELATED [] synonym: "cranial nerve VII" RELATED [] synonym: "face nerve" EXACT [] synonym: "Facial nerve [VII]" EXACT [] synonym: "facial nerve or its root" RELATED [] synonym: "facial nerve tree" EXACT [] synonym: "facial nerve/root" RELATED [] synonym: "facial VII" EXACT [] synonym: "facial VII nerve" EXACT [] synonym: "nerve of face" EXACT [] synonym: "nerve VII" RELATED [] synonym: "nervus facialis" EXACT [] synonym: "nervus facialis" RELATED [] synonym: "nervus facialis [vii]" EXACT [] synonym: "seventh cranial nerve" EXACT [] is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001456 ! face relationship: part_of UBERON:0001033 ! gustatory system relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0001678 name: temporal bone def: "The temporal bones are situated at the sides and base of the skull, and lateral to the temporal lobes of the cerebrum." [] synonym: "os temporale" RELATED [] is_a: UBERON:0003462 ! facial bone is_a: UBERON:0008193 ! pneumatized bone [Term] id: UBERON:0001690 name: ear def: "Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [] synonym: "auditory apparatus" RELATED [] synonym: "auris" RELATED [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0002105 ! vestibulo-auditory system [Term] id: UBERON:0001691 name: external ear def: "Part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO]." [] synonym: "auricular region" BROAD [] synonym: "auricular region of head" EXACT [] synonym: "auris externa" RELATED [] synonym: "outer ear" EXACT [] is_a: UBERON:0001444 ! subdivision of head relationship: part_of UBERON:0001690 ! ear [Term] id: UBERON:0001694 name: petrous part of temporal bone def: "The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted]." [] synonym: "pars petrosa (os temporale)" EXACT [] synonym: "pars petrosa ossis temporalis" EXACT [] synonym: "petromastoid part of temporal bone" EXACT [] synonym: "petrosal" BROAD [] synonym: "petrosal bone" EXACT [] synonym: "petrous bone" EXACT [] synonym: "temporal bone petrous part" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0001678 ! temporal bone relationship: part_of UBERON:0002517 ! basicranium [Term] id: UBERON:0001703 name: neurocranium def: "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." [] synonym: "brain box" EXACT [] synonym: "brain case" RELATED [] synonym: "brain pan" RELATED [] synonym: "braincase" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011158 ! primary subdivision of skull relationship: develops_from UBERON:0004761 ! cartilaginous neurocranium relationship: part_of UBERON:0003128 ! cranium [Term] id: UBERON:0001708 name: jaw skeleton def: "Subdivision of skeleton which includes upper and lower jaw skeletons." [] synonym: "anterior splanchnocranium" RELATED [] synonym: "jaw" EXACT [] synonym: "jaw cartilage" EXACT [] synonym: "jaws" RELATED [] synonym: "mandibular arch" RELATED [] synonym: "mandibular arch skeleton" EXACT [] synonym: "oral jaw skeleton" RELATED [] synonym: "pharyngeal arch 1 skeleton" RELATED [] synonym: "visceral arch 1" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010912 ! subdivision of skeleton relationship: part_of UBERON:0011595 ! jaw region [Term] id: UBERON:0001711 name: eyelid def: "An eyelid is a thin fold of skin that covers and protects an eyeball. With the exception of the prepuce and the labia minora, it has the thinnest skin of the whole body. The levator palpebrae superioris muscle retracts the eyelid to 'open' the eye. This can be either voluntarily or involuntarily. The human eyelid features a row of eyelashes which serve to heighten the protection of the eye from dust and foreign debris, as well as from perspiration. 'Palpebral' (and 'blepharo') means relating to the eyelids. Its key function is to regularly spread the tears and other secretion on the eye surface to keep it moist, since the cornea must be continuously moist. They keep the eyes from drying out when asleep. Moreover, the blink reflex protects the eye from foreign bodies. [WP,unvetted]." [] synonym: "blephara" RELATED [] synonym: "blepharon" EXACT [] synonym: "palpebra" EXACT [] synonym: "palpebrae" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001714 name: cranial ganglion def: "Ganglion of a cranial nerve[cjm]." [] synonym: "cranial ganglia" RELATED [] synonym: "cranial ganglion" EXACT [] synonym: "cranial ganglion/nerve" EXACT [] synonym: "cranial nerve ganglion" EXACT [] synonym: "cranial neural ganglion" EXACT [] synonym: "cranial neural tree organ ganglion" EXACT [] synonym: "ganglion of cranial nerve" EXACT [] synonym: "ganglion of cranial neural tree organ" EXACT [] synonym: "head ganglion" RELATED [] synonym: "presumptive cranial ganglia" RELATED [] is_a: UBERON:0000045 ! ganglion relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0001723 name: tongue def: "A muscular organ in the floor of the mouth." [] synonym: "glossus" RELATED [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013765 ! digestive system organ relationship: develops_from UBERON:0008814 ! pharyngeal system relationship: part_of UBERON:0000165 ! mouth relationship: part_of UBERON:0001033 ! gustatory system [Term] id: UBERON:0001728 name: nasopharynx def: "uppermost part of the pharynx. It extends from the base of the skull to the upper surface of the soft palate; it differs from the oral and laryngeal parts of the pharynx in that its cavity always remains patent (open)[WP]." [] synonym: "epipharynx" RELATED [] synonym: "nasal part of pharynx" EXACT [] synonym: "Nasenrachenraum" RELATED [] synonym: "pars nasalis pharyngis" RELATED [] synonym: "rhinopharynx" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001557 ! upper respiratory tract [Term] id: UBERON:0001735 name: tonsillar ring def: "lymphoid tissue ring located in the pharynx and to the back of the oral cavity. The ring consists of (from superior to inferior): Pharyngeal tonsil (also known as 'adenoids' when infected) Tubal tonsil (where Eustachian tube opens in the nasopharynx) Palatine tonsils (commonly called 'the tonsils' in the vernacular, less commonly termed 'faucial tonsils') Lingual tonsils Some animals, but not humans, have one or two additional tonsils: Soft palate tonsil Paraepiglottic tonsil[WP]." [] synonym: "anulus lymphoideus pharyngis" EXACT [] synonym: "oropharyngeal lymphoid tissue" EXACT [] synonym: "pharyngeal lymphatic ring" EXACT [] synonym: "pharyngeal lymphoid ring" EXACT [] synonym: "Waldeyer's ring" EXACT [] synonym: "Waldeyer's tonsillar ring" EXACT [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0001744 name: lymphoid tissue def: "Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP]." [] synonym: "lymphatic tissue" EXACT [] synonym: "lymphocytic tissue" EXACT [] is_a: UBERON:0000479 ! tissue relationship: part_of UBERON:0002193 ! hemolymphoid system relationship: part_of UBERON:0002465 ! lymphoid system [Term] id: UBERON:0001745 name: secondary nodular lymphoid tissue def: "A lymphoid follicle that contains a germinal center." [] synonym: "peripheral lymphoid tissue" EXACT [] synonym: "secondary lymphoid nodule" EXACT [] synonym: "secondary lymphoid tissue" EXACT [] is_a: UBERON:0000444 ! lymphoid follicle relationship: develops_from UBERON:0010422 ! primary nodular lymphoid tissue [Term] id: UBERON:0001747 name: parenchyma of thyroid gland def: "A parenchyma that is part of a thyroid follicle [Automatically generated definition]." [] synonym: "parenchyma glandulae thyroideae" RELATED [] synonym: "parenchyma of thyroid" EXACT [] synonym: "parenchyma of thyroid follicle" EXACT [] synonym: "parenchyma of thyroid gland follicle" EXACT [] synonym: "thyroid follicle parenchyma" EXACT [] synonym: "thyroid gland follicle parenchyma" EXACT [] synonym: "thyroid gland parenchyma" EXACT [] synonym: "thyroid parenchyma" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland [Term] id: UBERON:0001749 name: parenchyma of parathyroid gland def: "A parenchyma that is part of a parathyroid gland [Automatically generated definition]." [] synonym: "parathyroid gland parenchyma" EXACT [] synonym: "parathyroid parenchyma" EXACT [] synonym: "parenchyma of parathyroid" EXACT [] is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0001132 ! parathyroid gland [Term] id: UBERON:0001750 name: lacrimal apparatus def: "The lacrimal apparatus is the physiologic system containing the orbital structures for tear production and drainage. It consists of: (a) the lacrimal gland, which secretes the tears, and its excretory ducts, which convey the fluid to the surface of the eye; (b) the lacrimal canaliculi, the lacrimal sac, and the nasolacrimal duct, by which the fluid is conveyed into the cavity of the nose. [WP,unvetted]." [] synonym: "apparatus lacrimalis" RELATED [] synonym: "nasolacrimal drainage system" RELATED [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0010409 ! eye surface [Term] id: UBERON:0001751 name: dentine def: "Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular." [] synonym: "dentin" EXACT [] synonym: "dentine of tooth" EXACT [] synonym: "predentin" NARROW [] is_a: UBERON:0001973 ! substance of tooth is_a: UBERON:0010365 ! odontoid tissue relationship: develops_from UBERON:0011587 ! pre-dentine [Term] id: UBERON:0001752 name: enamel def: "A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP]." [] synonym: "enamel of tooth" EXACT [] synonym: "enamel tissue" EXACT [] synonym: "enameloid" RELATED [] synonym: "tooth enamel" EXACT [] is_a: UBERON:0001973 ! substance of tooth is_a: UBERON:0010365 ! odontoid tissue relationship: develops_from UBERON:0011588 ! pre-enamel [Term] id: UBERON:0001753 name: cementum def: "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument." [] synonym: "bone of attachment" RELATED [] synonym: "cement" EXACT [] synonym: "cement of tooth" EXACT [] synonym: "cementum" EXACT [] synonym: "cementum of tooth" EXACT [] is_a: UBERON:0001973 ! substance of tooth is_a: UBERON:0010365 ! odontoid tissue [Term] id: UBERON:0001754 name: dental pulp def: "the part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP]." [] synonym: "dental pulp cell" RELATED [] synonym: "pulp of tooth" EXACT [] synonym: "tooth pulp" EXACT [] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011825 ! loose connective tissue relationship: develops_from UBERON:0001763 ! odontogenic papilla relationship: part_of UBERON:0001091 ! calcareous tooth [Term] id: UBERON:0001756 name: middle ear def: "The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO]." [] synonym: "auris media" RELATED [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001690 ! ear [Term] id: UBERON:0001758 name: periodontium def: "The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO]." [] synonym: "paradentium" RELATED [] synonym: "periodontal ligament" RELATED [] synonym: "periodontal membrane" RELATED [] synonym: "tooth supporting structure" RELATED [] is_a: UBERON:0000479 ! tissue relationship: part_of UBERON:0003672 ! dentition [Term] id: UBERON:0001763 name: odontogenic papilla def: "Tissue of the developing tooth. It is composed of pre-odontoblast and undiffentiated mesnchyme cells and connects to the basal lamina[ZFA]. The dental papilla is a condensation of ectomesenchymal cells called odontoblasts, seen in histologic sections of a developing tooth. It lies below a cellular aggregation known as the enamel organ. The dental papilla appears after 8-10 weeks intra uteral life. The dental papilla gives rise to the dentin and pulp of a tooth. The enamel organ, dental papilla, and dental follicle together forms one unit, called the tooth germ. This is of importance because all the tissues of a tooth and its supporting structures form from these distinct cellular aggregations." [] synonym: "dental papilla" RELATED [] synonym: "dentinal papilla" RELATED [] synonym: "dermal papilla" RELATED [] synonym: "odontogenic condensation" EXACT [] synonym: "papilla dentis" RELATED [] synonym: "pharyngeal tooth mesenchyme" NARROW [] synonym: "tooth mesenchyme" RELATED [] is_a: UBERON:0003856 ! odontogenic mesenchyme is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: develops_from UBERON:0003856 ! odontogenic mesenchyme relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: UBERON:0001765 name: mammary duct def: "Epithelial tube that transports milk[GO]." [] synonym: "ductus lactiferi" RELATED [] synonym: "galactophorous duct" RELATED [] synonym: "galactophorous tubule" RELATED [] synonym: "lactiferous duct" EXACT [] synonym: "lactiferous gland duct" EXACT [] synonym: "lactiferous tubule" RELATED [] synonym: "mammary gland duct" EXACT [] synonym: "mammilary duct" RELATED [] is_a: UBERON:0000058 ! duct is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0001766 name: anterior chamber of eyeball def: "the fluid-filled space inside the eye between the iris and the cornea's innermost surface, the endothelium.[1] Aqueous humor is the fluid that fills the anterior chamber. Hyphema and glaucoma are two main pathologies in this area. In hyphema, blood fills the anterior chamber. In glaucoma, blockage of the canal of Schlemm prevents the normal outflow of aqueous humor, resulting in accumulation of fluid, increased intraocular pressure, and eventually blindness." [] synonym: "anterior chamber" EXACT [] synonym: "anterior chamber of eye" EXACT [] synonym: "camera anterior" EXACT [] synonym: "camera anterior bulbi" RELATED [] synonym: "camera anterior bulbi oculi" RELATED [] synonym: "camera oculi anterior" RELATED [] synonym: "eye anterior chamber" EXACT [] is_a: UBERON:0006311 ! chamber of eyeball relationship: part_of UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0001768 name: uvea def: "pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." [] synonym: "pars iridica retinae" RELATED [] synonym: "tunica vasculatis oculi" RELATED [] synonym: "tunica vasculosa bulbi" RELATED [] synonym: "tunica vasculosa of eyeball" EXACT [] synonym: "uvea" EXACT [] synonym: "uveal tract" EXACT [] synonym: "vascular layer of eyeball" RELATED [] is_a: UBERON:0002203 ! vasculature of eye relationship: part_of UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0001769 name: iris def: "a membrane in the eye, responsible for controlling the amount of light reaching the retina. The iris consists of pigmented fibrovascular tissue known as a stroma. It is the most forward portion of the eye and the only one seen on superficial inspection. The stroma connects a sphincter muscle (sphincter pupillae), which contracts the pupil, and a set of dilator muscles (dilator pupillae) which open it. The back surface is covered by a heavily pigmented epithelial layer two cells thick (the iris pigment epithelium), but the front surface has no epithelium. The high pigment content blocks light from passing through the iris and restricts it to the pupil. The outer edge of the iris, known as the root, is attached to the sclera and the anterior ciliary body. The iris and ciliary body together are known as the anterior uvea. Just in front of the root of the iris is the region through which the aqueous humour constantly drains out of the eye, with the result that diseases of the iris often have important effects on intraocular pressure, and indirectly on vision. Depending on the amount of light, the iris makes the pupil larger or smaller." [] synonym: "anterior uvea" RELATED [] synonym: "irises" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0004128 ! optic vesicle relationship: part_of UBERON:0011892 ! anterior uvea [Term] id: UBERON:0001770 name: lacrimal canaliculus def: "The lacrimal canaliculi, also known as the lacrimal canals or lacrimal ducts, are the small channels in each eyelid that commence at minute orifices, termed puncta lacrimalia, on the summits of the papillae lacrimales, seen on the margins of the lids at the lateral extremity of the lacus lacrimalis. The superior duct, the smaller and shorter of the two, at first ascends, and then bends at an acute angle, and passes medialward and downward to the lacrimal sac. The inferior duct at first descends, and then runs almost horizontally to the lacrimal sac. At the angles they are dilated into ampull. Microscopically, they are lined by nonkeratinizing stratified squamous epithelium surrounded by fibrous tissue. Outside the latter is a layer of striped muscle, continuous with the lacrimal part of the Orbicularis oculi; at the base of each lacrimal papilla the muscular fibers are circularly arranged and form a kind of sphincter. [WP,unvetted]." [] synonym: "canaliculus lacrimalis" RELATED [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001850 ! lacrimal duct [Term] id: UBERON:0001772 name: corneal epithelium def: "The corneal epithelium (epithelium corne anterior layer) is made up of epithelial tissue and covers the front of the cornea. It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei. [WP,unvetted]." [] synonym: "anterior corneal epithelium" EXACT [] synonym: "anterior endothelium of cornea" RELATED [] synonym: "cornea epithelial tissue" EXACT [] synonym: "cornea epithelium" EXACT [] synonym: "e. anterius corneae" RELATED [] synonym: "endothelium anterius corneae" RELATED [] synonym: "endothelium camerae anterioris bulbi" RELATED [] synonym: "endothelium corneale" RELATED [] synonym: "epithelial tissue of cornea" EXACT [] synonym: "epithelium anterius (cornea)" EXACT [] synonym: "epithelium anterius corneae" EXACT [] synonym: "epithelium of cornea" EXACT [] synonym: "epithelium posterius corneae" RELATED [] synonym: "external epithelium of cornea" EXACT [] is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: UBERON:0001773 name: sclera def: "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." [] synonym: "scleral capsule" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0012430 ! tunica fibrosa of eyeball [Term] id: UBERON:0001774 name: muscle of trunk def: "Muscle organ which is a part of the trunk. Examples: external intercostal muscle, external oblique, levator ani." [] synonym: "body musculature" EXACT [] synonym: "muscle organ of torso" EXACT [] synonym: "muscle organ of trunk" EXACT [] synonym: "torso muscle organ" EXACT [] synonym: "trunk muscle" EXACT [] synonym: "trunk muscle organ" EXACT [] synonym: "trunk musculature" EXACT [] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0005177 ! trunk organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0004479 ! musculature of trunk [Term] id: UBERON:0001775 name: ciliary body def: "circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [] synonym: "anterior uvea" RELATED [] synonym: "ciliary bodies" RELATED [] synonym: "corpus ciliare" RELATED [] synonym: "ocular ciliary body" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0011892 ! anterior uvea [Term] id: UBERON:0001776 name: optic choroid def: "vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [] synonym: "chorioid" RELATED [] synonym: "choroid" EXACT [] synonym: "choroid coat" EXACT [] synonym: "choroidea" EXACT [] synonym: "choroidea" RELATED [] synonym: "eye choroid" EXACT [] synonym: "optic choroid" RELATED [] synonym: "posterior uvea" EXACT [] is_a: UBERON:0002203 ! vasculature of eye relationship: part_of UBERON:0001768 ! uvea [Term] id: UBERON:0001777 name: substantia propria of cornea def: "The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent. It is composed of about 200 flattened lamell (plates of collagen fibrils), superimposed one on another. They are each about 1.5-2.5 micrometres in thickness. These fibrils run at different angles between the limbi. Fibres of the layers frequently interweave, the anterior lamell interweaving more than posterior lamell. The fibres of each lamella are parallel with one another, but at right angles to those of adjacent lamell. The lamell are produced by keratocytes (corneal corpuscles), which occupy about 10% of the substantia propria. These lamell are made up of bundles of modified connective tissue, the fibres of which are directly continuous with those of the sclera. More collagen fibres run in a temporal-nasal direction than run in the superior-inferior direction. This is often ignored by corneal transplant surgeons, leading to poor corneal mechanical strength in corneal transplant patients. [WP,unvetted]." [] synonym: "cornea stroma" EXACT [] synonym: "corneal stroma" EXACT [] synonym: "stroma of cornea" EXACT [] synonym: "substantia propria" RELATED [] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0003891 ! stroma is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0000964 ! cornea relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0000964 ! cornea [Term] id: UBERON:0001778 name: ciliary epithelium def: "A double layer covering the ciliary body that produces aqueous humor." [] synonym: "ciliary body epithelium" EXACT [] synonym: "epithelium of ciliary body" EXACT [] synonym: "ocular ciliary epithelium" EXACT [] is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001775 ! ciliary body relationship: part_of UBERON:0001775 ! ciliary body [Term] id: UBERON:0001780 name: spinal nerve def: "Neural tree (organ) which is directly continuous with the spinal cord. Examples: Fifth cervical spinal nerve, third lumbar spinal nerve." [] synonym: "backbone nerve" EXACT [] synonym: "nerve of backbone" EXACT [] synonym: "nerve of spinal column" EXACT [] synonym: "nerve of spine" EXACT [] synonym: "nerve of vertebral column" EXACT [] synonym: "nervi spinales" RELATED [] synonym: "spinal column nerve" EXACT [] synonym: "spinal nerve tree" EXACT [] synonym: "Spinal nerves" RELATED [] synonym: "spine nerve" EXACT [] synonym: "vertebral column nerve" EXACT [] is_a: UBERON:0001021 ! nerve relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0001781 name: layer of retina def: "any of the layers that make up the retina[MP]." [] synonym: "retina layer" EXACT [] synonym: "retina neuronal layer" EXACT [] synonym: "retinal layer" EXACT [] synonym: "retinal neuronal layer" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0000966 ! retina [Term] id: UBERON:0001782 name: pigmented layer of retina def: "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]." [] synonym: "epithelium, retinal pigment" RELATED [] synonym: "outer pigmented layer of retina" EXACT [] synonym: "p. pigmentosa retinae" RELATED [] synonym: "pigment epithelium of retina" EXACT [] synonym: "pigmented epithelium" RELATED [] synonym: "pigmented retina" RELATED [] synonym: "pigmented retina epithelium" EXACT [] synonym: "pigmented retinal epithelium" EXACT [] synonym: "PRE" RELATED [] synonym: "retinal pigment epithelium" EXACT [] synonym: "retinal pigment layer" RELATED [] synonym: "retinal pigmented epithelium" EXACT [] synonym: "RPE" RELATED [] synonym: "stratum pigmentosa retinae" RELATED [] synonym: "stratum pigmentosum (retina)" EXACT [] is_a: UBERON:0001781 ! layer of retina is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0001781 ! layer of retina intersection_of: develops_from UBERON:0005424 ! presumptive retinal pigmented epithelium relationship: develops_from UBERON:0005424 ! presumptive retinal pigmented epithelium [Term] id: UBERON:0001785 name: cranial nerve def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. In humans, there are traditionally twelve pairs of cranial nerves. Only the first and the second pair emerge from the cerebrum; the remaining ten pairs emerge from the brainstem[WP]." [] synonym: "cranial nerves" RELATED [] synonym: "cranial neural tree organ" EXACT [] synonym: "nervus cranialis" RELATED [] is_a: UBERON:0001021 ! nerve is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001800 name: sensory ganglion def: "the clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." [] synonym: "ganglion sensorium" EXACT [] is_a: UBERON:0000045 ! ganglion [Term] id: UBERON:0001801 name: anterior segment of eyeball def: "The anterior segment is the front third of the eye that includes the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens. Within the anterior segment are two fluid-filled spaces: the anterior chamber between the posterior surface of the cornea (i.e. the corneal endothelium) and the iris; the posterior chamber between the iris and the front face of the vitreous. Aqueous humor fills these spaces within the anterior segment and provides nutrients to the surrounding structures." [] synonym: "anterior eye segment" EXACT [] synonym: "anterior segment of eye" EXACT [] synonym: "anterior segment of the eye" EXACT [] synonym: "eye anterior segment" EXACT [] synonym: "segmentum anterius (bulbus oculi)" EXACT [] synonym: "segmentum anterius bulbi oculi" RELATED [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0010230 ! eyeball of camera-type eye [Term] id: UBERON:0001802 name: posterior segment of eyeball def: "The posterior segment is the back two-thirds of the eye that includes the anterior hyaloid membrane and all structures behind it: the vitreous humor, retina, choroid, and optic nerve. On the anterior side of the lens is the aqueous humour which is bounded on all sides by the lens, ciliary body, suspensory ligaments, and by the cornea. It lets light through without refraction, helps maintain the shape of the eye and suspends the delicate lens. In some animals, the retina contains a reflective layer (the tapetum lucidum) which increases the amount of light each photosensitive cell perceives, allowing the animal to see better under low light conditions." [] synonym: "eye posterior segment" EXACT [] synonym: "posterior eye segment" EXACT [] synonym: "posterior segment of eye" EXACT [] synonym: "posterior segment of the eye" EXACT [] synonym: "segmentum posterius (bulbus oculi)" EXACT [] synonym: "segmentum posterius bulbi oculi" RELATED [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0010230 ! eyeball of camera-type eye [Term] id: UBERON:0001803 name: epithelium of lens def: "The cells of the lens epithelium regulate most of the homeostatic functions of the lens.[6] As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions." [] synonym: "epithelial tissue of eye lens" EXACT [] synonym: "epithelial tissue of lens" EXACT [] synonym: "epithelium lentis" EXACT [] synonym: "epithelium of eye lens" EXACT [] synonym: "eye lens epithelial tissue" EXACT [] synonym: "eye lens epithelium" EXACT [] synonym: "lens epithelial tissue" EXACT [] synonym: "lens epithelium" EXACT [] is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000965 ! lens of camera-type eye relationship: part_of UBERON:0000965 ! lens of camera-type eye [Term] id: UBERON:0001805 name: autonomic ganglion def: "ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." [] synonym: "autonomic nervous system ganglion" EXACT [] synonym: "ganglion autonomicum" RELATED [] synonym: "ganglion of autonomic nervous system" EXACT [] synonym: "ganglion of visceral nervous system" EXACT [] synonym: "visceral nervous system ganglion" EXACT [] is_a: UBERON:0003338 ! ganglion of peripheral nervous system intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0001806 name: sympathetic ganglion def: "Sympathetic ganglia are the ganglia of the sympathetic nervous system. They deliver information to the body about stress and impending danger, and are responsible for the familiar fight-or-flight response. They are located close to and on either side of the spinal cord in long chains. [WP,unvetted]." [] synonym: "ganglion of sympathetic nervous system" EXACT [] synonym: "ganglion of sympathetic part of autonomic division of nervous system" EXACT [] synonym: "ganglion sympatheticum" EXACT [] synonym: "ganglion sympathicum" RELATED [] synonym: "sympathetic nervous system ganglion" EXACT [] synonym: "sympathetic part of autonomic division of nervous system ganglion" EXACT [] is_a: UBERON:0001805 ! autonomic ganglion is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0000013 ! sympathetic nervous system relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0000013 ! sympathetic nervous system [Term] id: UBERON:0001807 name: paravertebral ganglion def: "Trunk ganglion which is part of a bilaterally paired set of sympathetic ganglia located anterior and lateral to the spinal cord." [] synonym: "ganglion of sympathetic trunk" EXACT [] synonym: "ganglion trunci sympathetici" EXACT [] synonym: "ganglion trunci sympathici" EXACT [] synonym: "sympathetic chain ganglion" EXACT [] is_a: UBERON:0001806 ! sympathetic ganglion is_a: UBERON:0007134 ! trunk ganglion relationship: part_of UBERON:0000013 ! sympathetic nervous system [Term] id: UBERON:0001811 name: conjunctiva def: "The conjunctiva is a clear mucous membrane consisting of cells and underlying basement membrane that covers the sclera (white part of the eye) and lines the inside of the eyelids. It is made of epithelial tissue. [WP,unvetted]." [] synonym: "wall of conjunctival sac" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0005908 ! conjunctival sac relationship: part_of UBERON:0010409 ! eye surface [Term] id: UBERON:0001820 name: sweat gland def: "Sweat glands are exocrine glands, found in the skin of all mammal species, that are used for body temperature regulation. In humans a system of apocrine - and merocrine sweat glands is the main method of cooling. Many other mammals rely on panting or other means as a primary source of cooling, but still use sweat glands to aid in body temperature regulation. Sweat also serves a purpose of increasing friction on the palms of hands or the pads of paws. Both apocrine and merocrine sweat glands contain myoepithelial cells (from Greek myo-, 'muscle'), specialized epithelial cells located between the gland cells and the underlying basal lamina. Myoepithelial cell contractions squeeze the gland and discharge the accumulated secretions. The secretory activities of the gland cells and the contractions of myoepithelial cells are controlled by both the autonomic nervous system and by the circulating hormones. Additionally, ceruminous glands, which produce ear wax, and mammary glands, which produce milk, are frequently considered to be modified sweat glands. [WP,unvetted]." [] synonym: "glandula sudorifera" RELATED [] synonym: "sudoriferous gland" RELATED [] synonym: "sudoriparous gland" RELATED [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0007771 ! epidermis gland relationship: develops_from UBERON:0005089 ! sweat gland placode relationship: part_of UBERON:0001003 ! epidermis [Term] id: UBERON:0001821 name: sebaceous gland def: "A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]." [] synonym: "glandula sebacea" RELATED [] synonym: "glandula sebaceae" RELATED [] synonym: "sebaceous follicle" RELATED [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0012344 ! holocrine gland relationship: develops_from UBERON:0005088 ! sebaceous gland placode relationship: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0001823 name: nasal cartilage def: "One of the cartilage structures in the nose that provide form and support[WP]." [] synonym: "cartilage of nose" EXACT [] is_a: UBERON:0002418 ! cartilage tissue is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0000004 ! olfactory apparatus [Term] id: UBERON:0001826 name: nasal cavity mucosa def: "the mucous membrane that lines the nasal cavity[MP]." [] synonym: "mucosa of nose" EXACT [] synonym: "mucous membrane of nose" EXACT [] synonym: "nasal mucosa" RELATED [] synonym: "tunica mucosa nasalis" EXACT [] synonym: "tunica mucosa nasi" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0000004 ! olfactory apparatus [Term] id: UBERON:0001828 name: gingiva def: "The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001]." [] synonym: "gingival mucosa" RELATED [] synonym: "gum" EXACT [] synonym: "gum tissue" EXACT [] synonym: "gums" EXACT [] is_a: UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0011595 ! jaw region [Term] id: UBERON:0001837 name: duct of salivary gland def: "An intralobular duct found in salivary glands and involved in the production and transport of their secretions[BTO]." [] synonym: "salivary duct" EXACT [] synonym: "salivary gland duct" EXACT [] synonym: "secretory duct" RELATED [] is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0014719 ! intralobular duct intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001044 ! salivary gland relationship: part_of UBERON:0001044 ! salivary gland [Term] id: UBERON:0001839 name: bony labyrinth def: "A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." [] synonym: "labyrinthus osseus" RELATED [] synonym: "osseous labyrinth" EXACT [] synonym: "osseus labyrinth" RELATED [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0001694 ! petrous part of temporal bone relationship: part_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0004681 ! vestibular system [Term] id: UBERON:0001840 name: semicircular canal def: "One of three half-circular, interconnected tubes located inside each ear[WP]. Fluid-filled toroidal spaces, arranged orthogonally to each other in the ear, that detect angular accelerations[ZFIN]." [] synonym: "canalis semicircularis" RELATED [] synonym: "ductus semicirculares" RELATED [] synonym: "scc" RELATED [] synonym: "semicircular canals" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003051 ! ear vesicle relationship: part_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0001849 ! membranous labyrinth [Term] id: UBERON:0001844 name: cochlea def: "The cochlea is the auditory portion of the inner ear. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. The name is from the Latin for snail, which is from the Greek kokhlias 'snail, screw,' from kokhlos 'spiral shell,' in reference to its coiled shape; the cochlea is coiled in most mammals, monotremes being the exceptions. [WP,unvetted]." [] synonym: "cochleae" RELATED [] synonym: "cochlear duct" RELATED [] synonym: "cochlear organ" RELATED [] synonym: "cochlear part of bony labyrinth" EXACT [] synonym: "lagena" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0001839 ! bony labyrinth [Term] id: UBERON:0001846 name: internal ear def: "Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation." [] synonym: "auris interna" RELATED [] synonym: "inner ear" EXACT [] synonym: "labyrinth" RELATED [] synonym: "otocyst" RELATED [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003051 ! ear vesicle relationship: part_of UBERON:0001690 ! ear [Term] id: UBERON:0001849 name: membranous labyrinth def: "Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP]" [] synonym: "labyrinthus membranaceus" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0005641 ! otocyst epithelium relationship: part_of UBERON:0001846 ! internal ear [Term] id: UBERON:0001850 name: lacrimal duct def: "Organ with organ cavity which connects the vestibule of the conjunctival sac to the nasal cavity. Examples: There are only two lacrimal ducts, the right and the left lacrimal ducts.[FMA]" [] synonym: "lacrimal caniculus" RELATED [] synonym: "tear duct" RELATED [] is_a: UBERON:0000058 ! duct is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001750 ! lacrimal apparatus [Term] id: UBERON:0001851 name: cortex def: "Outermost layer of an organ[WP]." [] synonym: "cortex" EXACT [] synonym: "cortex of organ" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001853 name: utricle of membranous labyrinth def: "one of the two otolith organs located in the vertebrate inner ear. These use small stones and a viscous fluid to stimulate hair cells to detect motion and orientation. The utricle is larger than the saccule and is of an oblong form, compressed transversely, and occupies the upper and back part of the vestibule, lying in contact with the recessus ellipticus and the part below it. The utricle contains mechanoreceptors called hair cells that distinguish between degrees of tilting of the head, thanks to their apical cilia set-up. These are covered by otolith which, due to gravity, pull on the cilia and tilt them. Depending on whether the tilt is in the direction of the kinocilium or not, the resulting hair cell polarisation is excitatory (depolarising) or inhibitory (hyperpolarisation), respectively. This signal to the vestibular nerve (which takes it to the brainstem) does not adapt with time. The effect of this is that, for example, an individual lying down to sleep will continue to detect that they are lying down hours later when they awaken[WP]." [] synonym: "membranous labyrinth utricle" EXACT [] synonym: "utricle" EXACT [] synonym: "utriculus" EXACT [] synonym: "utriculus (labyrinthus vestibularis)" EXACT [] is_a: UBERON:0002518 ! otolith organ [Term] id: UBERON:0001854 name: saccule of membranous labyrinth def: "A bed of sensory cells situated in the inner ear. The saccule translates head movements into neural impulses which the brain can interpret. The saccule is sensitive to linear translations of the head, specifically movements up and down (think about moving on an elevator). When the head moves vertically, the sensory cells of the saccule are disturbed and the neurons connected to them begin transmitting impulses to the brain. These impulses travel along the vestibular portion of the eighth cranial nerve to the vestibular nuclei in the brainstem. is the smaller of the two vestibular sacs. It is globular in form and lies in the recessus sphricus near the opening of the scala vestibuli of the cochlea. Its cavity does not directly communicate with that of the utricle. The anterior part of the saccule exhibits an oval thickening, the macula acustica sacculi, or macula, to which are distributed the saccular filaments of the vestibular branch of the vestibulocochlear nerve, also known as the acoustic nerve or cranial nerve VIII[WP]." [] synonym: "membranous labyrinth saccule" EXACT [] synonym: "saccule" EXACT [] synonym: "sacculus" EXACT [] synonym: "sacculus" RELATED [] synonym: "sacculus (labyrinthus vestibularis)" EXACT [] is_a: UBERON:0002518 ! otolith organ [Term] id: UBERON:0001855 name: cochlear duct of membranous labyrinth def: "An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." [] synonym: "cochlea duct" EXACT [] synonym: "cochlear aqueduct" RELATED [] synonym: "cochlear duct" EXACT [] synonym: "ductus cochlearis" RELATED [] synonym: "membranous cochlea" RELATED [] synonym: "Reissner's canal" EXACT [] synonym: "Reissners canal" EXACT [] synonym: "scala media" RELATED [] synonym: "scala medias" EXACT [] synonym: "scala of Loewenberg" RELATED [] is_a: UBERON:0000025 ! tube is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002499 ! cochlear labyrinth [Term] id: UBERON:0001856 name: semicircular duct def: "any of the three loop-shaped membranous inner tubular parts of the semicircular canals that are about one-fourth the diameter of the corresponding outer bony canals, that communicate at each end with the utricle, and that have near one end an expanded ampulla containing an area of sensory epithelium" [] synonym: "ductus semicirculares" RELATED [] synonym: "membranous semicircular canal" RELATED [] is_a: UBERON:0000025 ! tube is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001840 ! semicircular canal relationship: part_of UBERON:0001862 ! vestibular labyrinth [Term] id: UBERON:0001862 name: vestibular labyrinth def: "The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals." [] synonym: "inner ear vestibular component" EXACT [] synonym: "labyrinthus vestibularis" RELATED [] synonym: "vestibular apparatus" RELATED [] synonym: "vestibular component" BROAD [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001849 ! membranous labyrinth [Term] id: UBERON:0001867 name: cartilage of external ear def: "A cartilage that is part of a external ear [Automatically generated definition]." [] synonym: "auricular region cartilage" EXACT [] synonym: "auricular region of head cartilage" EXACT [] synonym: "cartilage of auricular region" EXACT [] synonym: "cartilage of auricular region of head" EXACT [] synonym: "cartilage of outer ear" EXACT [] synonym: "external ear cartilage" EXACT [] synonym: "outer ear cartilage" EXACT [] is_a: UBERON:0001996 ! elastic cartilage tissue is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0001691 ! external ear relationship: part_of UBERON:0001691 ! external ear [Term] id: UBERON:0001869 name: cerebral hemisphere def: "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]" [] synonym: "cerebrum" RELATED [] synonym: "hemisphere" RELATED [] synonym: "Hemispheric regions" RELATED [] synonym: "hemispherium cerebri" RELATED [] synonym: "medial amygdalar nucleus" RELATED [] synonym: "nucleus amygdaloideus medialis" RELATED [] synonym: "nucleus medialis amygdalae" RELATED [] synonym: "telencephalic vesicle" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0001886 name: choroid plexus def: "A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces." [] synonym: "chorioid plexus" EXACT [] synonym: "choroid plexus of cerebral hemisphere" RELATED [] synonym: "CP" BROAD [] synonym: "plexus choroideus" EXACT [] synonym: "plexus choroideus" RELATED [] synonym: "ventricular choroid plexus" RELATED [] is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005284 ! brain vasculature is_a: UBERON:0005629 ! vascular plexus relationship: part_of UBERON:0004086 ! brain ventricle relationship: part_of UBERON:0005283 ! tela choroidea [Term] id: UBERON:0001890 name: forebrain def: "The most anterior region the brain including both the telencephalon and diencephalon." [] synonym: "FB" BROAD [] synonym: "prosencephalon" RELATED [] is_a: UBERON:0002616 ! regional part of brain relationship: develops_from UBERON:0003080 ! anterior neural tube relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0001891 name: midbrain def: "Organ component of neuraxis that has as its parts the tectum, cerebral peduncle, midbrain tegmentum and cerebral aqueduct[FMA]. The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally[ZFA]. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." [] synonym: "MB" BROAD [] synonym: "mesencephalon" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0009616 ! presumptive midbrain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0001892 name: rhombomere def: "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure. In human embryonic development, the rhombomeres are present by day 29[WP]." [] synonym: "future rhombencephalon" RELATED [] synonym: "hindbrain segment" BROAD [] synonym: "rhombomere" EXACT [] synonym: "rhombomeres" RELATED [] synonym: "segment of hindbrain" BROAD [] is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: part_of UBERON:0007277 ! presumptive hindbrain relationship: part_of UBERON:0007277 ! presumptive hindbrain [Term] id: UBERON:0001893 name: telencephalon def: "The telencephalon is the name for a large region within the brain that is attributed many functions. Many people refer to it as the cerebrum; however, it is technically referred to as the telencephalon. As a more technical definition, the telencephalon refers to the cerebral hemispheres and other, smaller structures within the brain, although the telencephalon is one of the larger divisions (in terms of number). It is the anterior-most embryological division of the brain that develops from the prosencephalon. The telencephalon is composed of the following sub-regions; Limbic system; Cerebral cortex or cortices of the cerebral hemispheres, Basal ganglia, Olfactory bulb. The telencephalon comprises what most people think of as the 'brain'. It lies on top of the brainstem and is the largest and most well-developed of the five major divisions of the brain. The telencephalon is the newest structure in the phylogenetic sense, with mammals having the largest and most well-developed among all species. It emerges from the prosencephalon, the first of three vesicles that form from the embryonic neural tube (Christine Fennema-Notestine)." [] synonym: "cell bridges of the ventral striatum" RELATED [] synonym: "cerebrum" EXACT [] synonym: "endbrain" EXACT [] synonym: "supratentorial region" BROAD [] is_a: UBERON:0002780 ! regional part of forebrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0014371 ! future telencephalon relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0001894 name: diencephalon def: "Organ component of neuraxis that has as its parts the epithalamus, thalamus, hypothalamus, subthalamus[FMA]. The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis)." [] synonym: "between brain" EXACT [] synonym: "betweenbrain" RELATED [] synonym: "DiE" BROAD [] synonym: "diencephalon" RELATED [] synonym: "dysgranular insular cortex" RELATED [] synonym: "interbrain" EXACT [] synonym: "mature diencephalon" EXACT [] synonym: "thalamencephalon" EXACT [] is_a: UBERON:0002780 ! regional part of forebrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0001895 name: metencephalon def: "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." [] synonym: "epencephalon" BROAD [] is_a: UBERON:0004733 ! segmental subdivision of hindbrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0001896 name: medulla oblongata def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [] synonym: "bulb" BROAD [] synonym: "bulbus" EXACT [] synonym: "medial orbital cortex" RELATED [] synonym: "medulla" BROAD [] synonym: "medulla oblonzata" RELATED [] synonym: "metepencephalon" RELATED [] synonym: "somatic motor areas" RELATED [] synonym: "somatomotor areas" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002298 ! brainstem relationship: part_of UBERON:0005290 ! myelencephalon [Term] id: UBERON:0001898 name: hypothalamus def: "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]." [] synonym: "Hy" BROAD [] synonym: "hypothalamus" RELATED [] synonym: "preoptico-hypothalamic area" EXACT [] synonym: "preoptico-hypothalamic region" EXACT [] is_a: UBERON:0002784 ! regional part of diencephalon relationship: part_of UBERON:0000349 ! limbic system relationship: part_of UBERON:0010225 ! thalamic complex [Term] id: UBERON:0001901 name: epithelium of trachea def: "An epithelium that is part of a trachea." [] synonym: "epithelial tissue of trachea" EXACT [] synonym: "epithelial tissue of windpipe" EXACT [] synonym: "epithelium of windpipe" EXACT [] synonym: "trachea epithelial tissue" EXACT [] synonym: "trachea epithelium" EXACT [] synonym: "tracheal epithelium" EXACT [] synonym: "windpipe epithelial tissue" EXACT [] synonym: "windpipe epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0003258 ! endoderm of foregut relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0001902 name: epithelium of small intestine def: "An epithelium that is part of a small intestine [Automatically generated definition]." [] synonym: "epithelial tissue of small bowel" EXACT [] synonym: "epithelial tissue of small intestine" EXACT [] synonym: "epithelium of small bowel" EXACT [] synonym: "mid intestine epithelium" EXACT [] synonym: "small bowel epithelial tissue" EXACT [] synonym: "small bowel epithelium" EXACT [] synonym: "small intestinal epithelium" EXACT [] synonym: "small intestine epithelial tissue" EXACT [] synonym: "small intestine epithelium" EXACT [] is_a: UBERON:0001277 ! intestinal epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001204 ! mucosa of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001911 name: mammary gland def: "The specialized accessory gland of the skin of female mammals that secretes milk. In the human female, it is a compound tubuloalveolar gland composed of 15 to 25 lobes arranged radially about the nipple and separated by connective and adipose tissue, each lobe having its own excretory (lactiferous) duct opening on the nipple. The lobes are subdivided into lobules, with the alveolar ducts and alveoli being the secretory portion of the gland[BTO]. The mouse forms five to six pairs of mammary glands that extend from the neck to the groin." [] synonym: "Brustdruese" RELATED [] synonym: "dug" RELATED [] synonym: "glandula mammaria" EXACT [] synonym: "glandula mammaria" RELATED [] synonym: "lactiferous gland" EXACT [] synonym: "lobe of breast" EXACT [] synonym: "lobe of mammary gland" EXACT [] synonym: "mamma" RELATED [] synonym: "mammae" RELATED [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005398 ! female reproductive gland relationship: develops_from UBERON:0005333 ! mammary bud relationship: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0003100 ! female organism [Term] id: UBERON:0001912 name: lobule of lactiferous gland def: "Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA]" [] synonym: "acinus of mammary gland" EXACT [] synonym: "breast lobe" RELATED [] synonym: "lactiferous acinus" EXACT [] synonym: "lactiferous gland lobule" EXACT [] synonym: "lactiferous lobule" EXACT [] synonym: "lobe of breast" RELATED [] synonym: "lobe of mammary gland" RELATED [] synonym: "lobi glandulae mammariae" RELATED [] synonym: "lobule of mammary gland" EXACT [] synonym: "lobus glandulae mammariae" RELATED [] synonym: "mammary acinus" EXACT [] synonym: "mammary gland lobule" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0001915 name: endothelium of capillary def: "An endothelium that is part of a capillary [Automatically generated definition]." [] synonym: "blood capillary endothelium" EXACT [] synonym: "capillary endothelium" EXACT [] synonym: "capillary vessel endothelium" EXACT [] synonym: "endothelium of blood capillary" EXACT [] synonym: "endothelium of capillary vessel" EXACT [] is_a: UBERON:0004638 ! blood vessel endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001982 ! capillary relationship: part_of UBERON:0001982 ! capillary [Term] id: UBERON:0001916 name: endothelium of arteriole def: "An endothelium that is part of an arteriole [Automatically generated definition]." [] synonym: "arteriole endothelium" EXACT [] is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole [Term] id: UBERON:0001917 name: endothelium of artery def: "An endothelium that is part of an artery [Automatically generated definition]." [] synonym: "arterial endothelium" EXACT [] synonym: "artery endothelium" EXACT [] is_a: UBERON:0003915 ! endothelial tube is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0001918 name: endothelium of venule def: "An endothelium that is part of a venule [Automatically generated definition]." [] synonym: "venule endothelium" EXACT [] is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule [Term] id: UBERON:0001919 name: endothelium of vein def: "An endothelium that is part of a vein [Automatically generated definition]." [] synonym: "vein endothelium" EXACT [] synonym: "veinous endothelium" RELATED [] synonym: "venous endothelium" EXACT [] is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein [Term] id: UBERON:0001930 name: paraventricular nucleus of hypothalamus def: "The paraventricular nucleus (PVN) is a neuronal nucleus in the hypothalamus. It contains multiple subpopulations of neurons that are activated by a variety of stressful and/or physiological changes. Many PVH neurons project directly to the posterior pituitary where they release oxytocin or vasopressin into the general circulation. Other PVN neurons control various anterior pituitary functions, while still others directly regulate appetite and autonomic functions in the brainstem and spinal cord. [WP,unvetted]." [] synonym: "filiform nucleus" EXACT [] synonym: "nuclei paraventriculares" RELATED [] synonym: "nuclei paraventricularis hypothalami" RELATED [] synonym: "nucleus filiformis" RELATED [] synonym: "nucleus hypothalami filiformis" RELATED [] synonym: "nucleus hypothalami paraventricularis" RELATED [] synonym: "nucleus paraventricularis hypothalami" RELATED [] synonym: "Pa" BROAD [] synonym: "paraventricular hypothalamic nucleus" EXACT [] synonym: "paraventricular nucleus" EXACT [] synonym: "paraventricular nucleus hypothalamus (Malone)" RELATED [] synonym: "paraventricular nucleus of the hypothalamus" RELATED [] synonym: "parvocellular hypothalamic nucleus" RELATED [] synonym: "subcommissural nucleus (Ziehen)" RELATED [] is_a: UBERON:0006568 ! hypothalamic nucleus relationship: part_of UBERON:0002271 ! periventricular zone of hypothalamus [Term] id: UBERON:0001943 name: midbrain tegmentum def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN10:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." [] synonym: "mesencephalic tegmentum" RELATED [] synonym: "MTg" BROAD [] synonym: "tegmentum" BROAD [] synonym: "tegmentum mesencephali" EXACT [] synonym: "tegmentum mesencephalicum" RELATED [] synonym: "tegmentum of midbrain" EXACT [] is_a: UBERON:0002950 ! regional part of midbrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0010285 ! midbrain basal plate relationship: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0002298 ! brainstem [Term] id: UBERON:0001948 name: regional part of spinal cord def: "A multi-tissue structure that is part of a spinal cord." [] synonym: "spinal cord part" RELATED [] is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0001949 name: gingival epithelium def: "A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO]." [] synonym: "epithelial tissue of gingiva" EXACT [] synonym: "epithelium of gingiva" EXACT [] synonym: "gingiva epithelial tissue" EXACT [] synonym: "gingiva epithelium" EXACT [] is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0006915 ! stratified squamous epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001828 ! gingiva relationship: part_of UBERON:0001828 ! gingiva [Term] id: UBERON:0001951 name: epithelium of nasopharynx def: "An epithelium that is part of a nasopharynx [Automatically generated definition]." [] synonym: "epithelial tissue of nasal part of pharynx" EXACT [] synonym: "epithelial tissue of nasopharynx" EXACT [] synonym: "epithelial tissue of rhinopharynx" EXACT [] synonym: "epithelium of nasal part of pharynx" EXACT [] synonym: "epithelium of rhinopharynx" EXACT [] synonym: "nasal part of pharynx epithelial tissue" EXACT [] synonym: "nasal part of pharynx epithelium" EXACT [] synonym: "nasopharyngeal epithelium" RELATED [] synonym: "nasopharynx epithelial tissue" EXACT [] synonym: "nasopharynx epithelium" EXACT [] synonym: "rhinopharynx epithelial tissue" EXACT [] synonym: "rhinopharynx epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003351 ! pharyngeal epithelium is_a: UBERON:0004814 ! upper respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0003929 ! gut epithelium [Term] id: UBERON:0001954 name: Ammon's horn def: "A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum." [] synonym: "ammon gyrus" EXACT [] synonym: "ammon horn" EXACT [] synonym: "Ammon horn fields" RELATED [] synonym: "Ammon's horn" EXACT [] synonym: "Ammons horn" RELATED [] synonym: "cornu ammonis" RELATED [] synonym: "hippocampus" RELATED [] synonym: "hippocampus major" EXACT [] synonym: "hippocampus proper" EXACT [] synonym: "hippocampus proprius" EXACT [] is_a: UBERON:0002619 ! regional part of cerebral cortex relationship: part_of UBERON:0000349 ! limbic system relationship: part_of UBERON:0002421 ! hippocampal formation relationship: part_of UBERON:0002600 ! limbic lobe [Term] id: UBERON:0001955 name: epithelium of respiratory bronchiole def: "An epithelium that is part of a respiratory bronchiole [Automatically generated definition]." [] synonym: "bronchiolus respiratorius epithelial tissue" EXACT [] synonym: "bronchiolus respiratorius epithelium" EXACT [] synonym: "epithelial tissue of bronchiolus respiratorius" EXACT [] synonym: "epithelial tissue of respiratory bronchiole" EXACT [] synonym: "epithelium of bronchiolus respiratorius" EXACT [] synonym: "respiratory bronchiole epithelial tissue" EXACT [] synonym: "respiratory bronchiole epithelium" EXACT [] is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002188 ! respiratory bronchiole relationship: part_of UBERON:0002188 ! respiratory bronchiole [Term] id: UBERON:0001956 name: cartilage of bronchus def: "the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." [] synonym: "bronchi cartilage" EXACT [] synonym: "bronchial cartilage" EXACT [] synonym: "bronchial cartilage ring" EXACT [] synonym: "bronchial trunk cartilage" EXACT [] synonym: "bronchus cartilage" EXACT [] synonym: "cartilage of bronchi" EXACT [] synonym: "cartilage of bronchial trunk" EXACT [] synonym: "cartilagines bronchiales" EXACT [] is_a: UBERON:0001994 ! hyaline cartilage tissue is_a: UBERON:0003592 ! bronchus connective tissue is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0001957 name: submucosa of bronchus def: "A submucosa that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi submucosa" EXACT [] synonym: "bronchial submucosa" EXACT [] synonym: "bronchial trunk submucosa" EXACT [] synonym: "bronchus submucosa" EXACT [] synonym: "submucosa of bronchi" EXACT [] synonym: "submucosa of bronchial trunk" EXACT [] synonym: "submucous layer of bronchi" RELATED [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0001958 name: epithelium of terminal bronchiole def: "An epithelium that is part of a terminal bronchiole [Automatically generated definition]." [] synonym: "bronchiolus terminalis epithelial tissue" EXACT [] synonym: "bronchiolus terminalis epithelium" EXACT [] synonym: "epithelial tissue of bronchiolus terminalis" EXACT [] synonym: "epithelial tissue of terminal bronchiole" EXACT [] synonym: "epithelium of bronchiolus terminalis" EXACT [] synonym: "terminal bronchiole epithelial tissue" EXACT [] synonym: "terminal bronchiole epithelium" EXACT [] is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002187 ! terminal bronchiole relationship: part_of UBERON:0002187 ! terminal bronchiole [Term] id: UBERON:0001959 name: white pulp of spleen def: "The white pulp contains T cells, B cells and accessory cells. The function of the white pulp is to mount an immunological response to antigens within the blood. The white pulp is present in the form of a periarteriolar lymphoid sheath. This sheath contains B cell follicles and T cells. At the edge of the T zone is a region known as the marginal zone where larger lymphocytes and antigen presenting dendritic cells are located." [] synonym: "noduli lymphoidei splenici" RELATED [] synonym: "pulpa alba" EXACT [] synonym: "spleen white pulp" EXACT [] synonym: "splenic white pulp" EXACT [] synonym: "white pulp" EXACT [] is_a: UBERON:1000023 ! spleen pulp [Term] id: UBERON:0001961 name: mucosa-associated lymphoid tissue def: "diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." [] synonym: "epithelio-lymphoid tissue" EXACT [] synonym: "MALT" EXACT [] synonym: "mucosa associated lymphatic tissue" EXACT [] synonym: "mucosa associated lymphoid tissue" EXACT [] synonym: "mucosa-associated lymphoid tissue" EXACT [] synonym: "mucosal-associated lymphatic tissue" EXACT [] synonym: "mucosal-associated lymphoid tissue" EXACT [] is_a: UBERON:0012069 ! epithelium-associated lymphoid tissue [Term] id: UBERON:0001962 name: gut-associated lymphoid tissue def: "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." [] synonym: "GALT" RELATED [] synonym: "gut associated lymphoid tissue" EXACT [] is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0001963 name: bronchial-associated lymphoid tissue def: "A diffuse collection of lymphpoid cells that participate in airway immune responses" [] synonym: "BALT" RELATED [] synonym: "bronchus associated lymphoid tissue" EXACT [] is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0001972 name: submucosa of esophagus def: "A submucosa that is part of a esophagus [Automatically generated definition]." [] synonym: "esophageal submucosa" EXACT [] synonym: "esophagus submucosa" EXACT [] synonym: "gullet submucosa" EXACT [] synonym: "oesophagus submucosa" EXACT [] synonym: "submucosa of esophagus" EXACT [] synonym: "submucosa of gullet" EXACT [] synonym: "submucosa of oesophagus" EXACT [] synonym: "submucous layer of esophagus" RELATED [] synonym: "tela submucosa esophagi" EXACT [] synonym: "tela submucosa oesophageae" EXACT [] synonym: "tela submucosa oesophagi" RELATED [] synonym: "tela submucosa of esophagus" EXACT [] is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0001973 name: substance of tooth def: "Body substance in solid state produced by odontoblasts, amyloblasts or cementoblasts.[FMA]" [] synonym: "portion of substance of tooth" EXACT [] synonym: "tooth substance" EXACT [] is_a: UBERON:0000463 ! portion of organism substance relationship: part_of UBERON:0001091 ! calcareous tooth [Term] id: UBERON:0001974 name: lamina propria of esophagus def: "A lamina propria that is part of a esophagus [Automatically generated definition]." [] synonym: "esophagus lamina propria" EXACT [] synonym: "esophagus lamina propria mucosa" EXACT [] synonym: "esophagus lamina propria mucosae" EXACT [] synonym: "gullet lamina propria" EXACT [] synonym: "gullet lamina propria mucosa" EXACT [] synonym: "gullet lamina propria mucosae" EXACT [] synonym: "lamina propria mucosa of esophagus" EXACT [] synonym: "lamina propria mucosa of gullet" EXACT [] synonym: "lamina propria mucosa of oesophagus" EXACT [] synonym: "lamina propria mucosae of esophagus" EXACT [] synonym: "lamina propria mucosae of gullet" EXACT [] synonym: "lamina propria mucosae of oesophagus" EXACT [] synonym: "lamina propria of gullet" EXACT [] synonym: "lamina propria of oesophagus" EXACT [] synonym: "oesophagus lamina propria" RELATED [] synonym: "oesophagus lamina propria mucosa" EXACT [] synonym: "oesophagus lamina propria mucosae" EXACT [] is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0002469 ! esophagus mucosa [Term] id: UBERON:0001975 name: serosa of esophagus def: "A serous membrane that is part of a esophagus [Automatically generated definition]." [] synonym: "esophagus serosa" EXACT [] synonym: "esophagus serous membrane" EXACT [] synonym: "gullet serosa" EXACT [] synonym: "gullet serous membrane" EXACT [] synonym: "oesophagus serosa" RELATED [] synonym: "oesophagus serous membrane" EXACT [] synonym: "serosa of abdominal part of esophagus" EXACT [] synonym: "serosa of gullet" EXACT [] synonym: "serosa of oesophagus" EXACT [] synonym: "serous coat of oesophagus" EXACT [] synonym: "serous membrane of esophagus" EXACT [] synonym: "serous membrane of gullet" EXACT [] synonym: "serous membrane of oesophagus" EXACT [] synonym: "tunica serosa oesophageae" EXACT [] is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0001976 name: epithelium of esophagus def: "An epithelium that is part of a esophagus." [] synonym: "epithelial tissue of esophagus" EXACT [] synonym: "epithelial tissue of gullet" EXACT [] synonym: "epithelial tissue of oesophagus" EXACT [] synonym: "epithelium of gullet" EXACT [] synonym: "epithelium of oesophagus" EXACT [] synonym: "esophageal epithelium" EXACT [] synonym: "esophagus epithelial tissue" EXACT [] synonym: "esophagus epithelium" EXACT [] synonym: "gullet epithelial tissue" EXACT [] synonym: "gullet epithelium" EXACT [] synonym: "oesophagus epithelial tissue" EXACT [] synonym: "oesophagus epithelium" RELATED [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! gut epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0002469 ! esophagus mucosa [Term] id: UBERON:0001979 name: venule def: "Subdivision of venous tree (organ) which is directly continuous with the capillary vessel." [] synonym: "venula" RELATED [] is_a: UBERON:0003920 ! venous blood vessel relationship: part_of UBERON:0001009 ! circulatory system [Term] id: UBERON:0001980 name: arteriole def: "the smallest division of the artery located between the muscular arteries and the capillaries[GO]. Subdivision of arterial tree (organ) which is directly continuous with capillary vessel[FMA]." [] synonym: "arteriola" RELATED [] is_a: UBERON:0003509 ! arterial blood vessel relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0001981 name: blood vessel def: "A vessel through which blood circulates in the body." [] synonym: "region of vascular tree organ" EXACT [] synonym: "vas sanguineum" RELATED [] synonym: "vascular tree organ region" EXACT [] is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: develops_from UBERON:0006965 ! vascular cord relationship: part_of UBERON:0004537 ! blood vasculature [Term] id: UBERON:0001982 name: capillary def: "Any of the smallest blood vessels connecting arterioles with venules." [] synonym: "blood capillary" EXACT [] synonym: "capillary vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0010523 ! microcirculatory vessel [Term] id: UBERON:0001983 name: crypt of Lieberkuhn def: "A tubular gland found in the epithelial lining of the intestine and colon." [] synonym: "crypt of lieberkuhn" EXACT [] synonym: "crypt of Lieberkhn" EXACT [] synonym: "crypts of Lieberkhn" EXACT [] synonym: "follicles of lieberkuhn" EXACT [] synonym: "intestinal crypt" EXACT [] synonym: "intestinal crypts" EXACT [] synonym: "intestinal gland" BROAD [] synonym: "Lieberkuhn crypt" EXACT [] synonym: "lieberkuhn crypt" EXACT [] synonym: "Lieberkuhn gland" EXACT [] synonym: "Lieberkuhn's gland" EXACT [] synonym: "Lieberkuhn's glands" EXACT [] is_a: UBERON:0000333 ! intestinal gland relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0001984 name: crypt of lieberkuhn of large intestine def: "A crypt of lieberkuhn that is part of a large intestine [Automatically generated definition]." [] synonym: "intestinal gland of large intestine" EXACT [] synonym: "large intestinal crypt of lieberkuhn" EXACT [] synonym: "large intestine crypt of lieberkuhn" EXACT [] synonym: "large intestine intestinal gland" EXACT [] synonym: "large intestine lieberkuhn crypt" EXACT [] synonym: "lieberkuhn crypt of large intestine" EXACT [] is_a: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001207 ! mucosa of large intestine [Term] id: UBERON:0001985 name: corneal endothelium def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." [] synonym: "cornea endothelium" EXACT [] synonym: "endothelium of cornea" EXACT [] synonym: "epithelium posterius corneae" RELATED [] is_a: UBERON:0001772 ! corneal epithelium is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: UBERON:0001986 name: endothelium def: "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]" [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0001987 name: placenta def: "organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." [] synonym: "allantoic placenta" EXACT [] synonym: "eutherian placenta" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: develops_from UBERON:0000995 ! uterus relationship: develops_from UBERON:0003124 ! chorion relationship: develops_from UBERON:0004340 ! allantois relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: UBERON:0001992 name: papillary layer of dermis def: "Dense irregular connective tissue of the skin that consists of fibroblasts, various connective tissue cell types, and collagen, predominantly type III.[FMA]" [] synonym: "corpus papillary" EXACT [] synonym: "dermis papillary layer" EXACT [] synonym: "papillary dermis" EXACT [] synonym: "papillary layer" EXACT [] synonym: "papillary layer of dermis" EXACT [] synonym: "stratum papillare" EXACT [] synonym: "stratum papillare" RELATED [] synonym: "stratum papillare corii" EXACT [] synonym: "superficial dermis" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0002067 ! dermis [Term] id: UBERON:0001994 name: hyaline cartilage tissue def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." [] synonym: "hyaline cartilage" EXACT [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0001995 name: fibrocartilage def: "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns." [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0001996 name: elastic cartilage tissue def: "Cartilage tissue that is flexible and contains abundant elastic fibers." [] synonym: "elastic cartilage" EXACT [] synonym: "elastic cartilage tissue" EXACT [] synonym: "yellow elastic cartilage" EXACT [] synonym: "yellow elastic cartilage tissue" EXACT [] is_a: UBERON:0011589 ! non-mineralized cartilage tissue relationship: develops_from UBERON:0005863 ! cartilaginous condensation [Term] id: UBERON:0001997 name: olfactory epithelium def: "Epithelium inside the nasal cavity that is responsible for detecting odors[WP]." [] synonym: "nasal cavity olfactory epithelium" EXACT [] synonym: "nasal epithelium" RELATED [] synonym: "nasal sensory epithelium" RELATED [] synonym: "olfactory membrane" EXACT [] synonym: "olfactory mucosa" RELATED [] synonym: "olfactory sensory epithelium" EXACT [] synonym: "sensory olfactory epithelium" EXACT [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium relationship: develops_from UBERON:0003050 ! olfactory placode relationship: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000012 ! somatic nervous system relationship: part_of UBERON:0001826 ! nasal cavity mucosa [Term] id: UBERON:0002005 name: enteric nervous system def: "The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO]." [] synonym: "PNS - enteric" EXACT [] is_a: UBERON:0002410 ! autonomic nervous system is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0005428 ! vagal neural crest relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0002006 name: cortex of lymph node def: "Peripheral portion of the lymph node, underneath the capsule[WP]." [] synonym: "cortex nodi lymphoidei" RELATED [] synonym: "lymph node cortex" EXACT [] is_a: UBERON:0001851 ! cortex intersection_of: UBERON:0001851 ! cortex intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0002007 name: medulla of lymph node def: "." [] synonym: "lymph node medulla" EXACT [] synonym: "medulla nodi lymphoidei" RELATED [] is_a: UBERON:0000958 ! medulla intersection_of: UBERON:0000958 ! medulla intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0002012 name: pulmonary artery def: "The pulmonary arteries carry blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood. In the human heart, the pulmonary trunk (pulmonary artery or main pulmonary artery) begins at the base of the right ventricle. It is short and wide - approximately 5 cm (2 inches) in length and 3 cm (1.2 inches) in diameter. It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung. [WP,unvetted]." [] synonym: "arteria pulmonalis" RELATED [] synonym: "pulmonary arterial tree" EXACT [] synonym: "pulmonary arterial tree organ part" EXACT [] synonym: "truncus pulmonalis" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001637 ! artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0008886 ! pulmonary vascular system relationship: develops_from UBERON:0002061 ! truncus arteriosus relationship: part_of UBERON:0008886 ! pulmonary vascular system [Term] id: UBERON:0002018 name: synovial membrane of synovial joint def: "Soft tissue that lines the non-cartilaginous surfaces within joints with cavities (synovial joints)." [] synonym: "membrana synovialis capsulae articularis" EXACT [] synonym: "stratum synoviale" EXACT [] synonym: "synovial layer" BROAD [] synonym: "synovial layer of articular capsule of synovial joint" RELATED [] synonym: "synovial membrane" BROAD [] synonym: "synovial membrane of articular capsule of synovial joint" RELATED [] synonym: "synovium" BROAD [] synonym: "synovium of articular capsule of synovial joint" RELATED [] is_a: UBERON:0006915 ! stratified squamous epithelium is_a: UBERON:0007616 ! layer of synovial tissue is_a: UBERON:0012275 ! meso-epithelium relationship: part_of UBERON:0002217 ! synovial joint [Term] id: UBERON:0002020 name: gray matter of neuraxis def: "Heterogeneous cluster of neural somas in the brain and the spinal cord." [] synonym: "gray mater" RELATED [] synonym: "gray matter" EXACT [] synonym: "grey matter" EXACT [] synonym: "grey substance" EXACT [] synonym: "grisea" RELATED [] synonym: "neuronal grey matter" EXACT [] synonym: "substantia grisea" EXACT [] is_a: UBERON:0011215 ! cell part cluster of neuraxis relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0002025 name: stratum basale of epidermis def: "Deepest layer of the layers of the epidermis[WP]." [] synonym: "basal cell layer of epidermis" EXACT [] synonym: "basal cell layer of skin" RELATED [] synonym: "epidermal basal stratum" EXACT [] synonym: "epidermis basal layer" RELATED [] synonym: "epidermis stratum basale" EXACT [] synonym: "epidermis stratum germinativum" RELATED [] synonym: "Malpighian layer" RELATED [] synonym: "rete Malphighii" EXACT [] synonym: "stratum basale" BROAD [] synonym: "stratum basalis of epidermis" EXACT [] synonym: "stratum germinativum" EXACT [] synonym: "stratum Malphighi" EXACT [] is_a: UBERON:0013754 ! layer of skin relationship: part_of UBERON:0001003 ! epidermis [Term] id: UBERON:0002027 name: stratum corneum of epidermis def: "outermost cornified layer of the epidermis, composed of large, flat, polyhedral, plate-like envelopes filled with keratin, which is made up of dead cells that have migrated up from the stratum granulosum." [] synonym: "cornified layer" EXACT [] synonym: "epidermis stratum corneum" EXACT [] synonym: "horny layer" BROAD [] synonym: "horny layer of epidermis" EXACT [] synonym: "stratum corneum" BROAD [] synonym: "stratum corneum epidermidis" RELATED [] is_a: UBERON:0003055 ! periderm is_a: UBERON:0013754 ! layer of skin [Term] id: UBERON:0002028 name: hindbrain def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [] synonym: "rhombencephalon" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0007277 ! presumptive hindbrain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0002029 name: epithelium of gall bladder def: "the simple columnar epithelial lining of the gall bladder." [] synonym: "biliary epithelium" RELATED [] synonym: "epithelial tissue of gall bladder" EXACT [] synonym: "epithelial tissue of gallbladder" EXACT [] synonym: "epithelium of gallbladder" EXACT [] synonym: "gall bladder epithelial tissue" EXACT [] synonym: "gall bladder epithelium" EXACT [] synonym: "gallbladder epithelial tissue" EXACT [] synonym: "gallbladder epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: UBERON:0002031 name: epithelium of bronchus def: "An epithelium that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi epithelial tissue" EXACT [] synonym: "bronchi epithelium" EXACT [] synonym: "bronchial epithelium" EXACT [] synonym: "bronchial trunk epithelial tissue" EXACT [] synonym: "bronchial trunk epithelium" EXACT [] synonym: "bronchus epithelial tissue" EXACT [] synonym: "bronchus epithelium" EXACT [] synonym: "epithelial tissue of bronchi" EXACT [] synonym: "epithelial tissue of bronchial trunk" EXACT [] synonym: "epithelial tissue of bronchus" EXACT [] synonym: "epithelium of bronchi" EXACT [] synonym: "epithelium of bronchial trunk" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0002036 name: striated muscle tissue def: "Tissue which consists of striated muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue, Cardiac muscle tissue[FMA]." [] synonym: "striated muscle" EXACT [] is_a: UBERON:0002385 ! muscle tissue [Term] id: UBERON:0002037 name: cerebellum def: "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." [] synonym: "cell bridges of the ventral striatum" RELATED [] synonym: "corpus cerebelli" RELATED [] synonym: "infratentorial region" BROAD [] synonym: "parencephalon" RELATED [] is_a: UBERON:0002680 ! regional part of metencephalon relationship: develops_from UBERON:0006215 ! rhombic lip relationship: part_of UBERON:0001895 ! metencephalon relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0002038 name: substantia nigra def: "Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM)." [] synonym: "nucleus of basis pedunculi" EXACT [] synonym: "nucleus pigmentosus subthalamo-peduncularis" RELATED [] synonym: "SN" BROAD [] synonym: "Soemmering's substance" EXACT [] synonym: "substancia nigra" RELATED [] synonym: "substantia nigra (Soemmerringi)" RELATED [] is_a: UBERON:0009661 ! midbrain nucleus relationship: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0002420 ! basal ganglion [Term] id: UBERON:0002042 name: lymphatic vessel endothelium def: "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." [] synonym: "endothelium of lymph vessel" EXACT [] synonym: "endothelium of lymphatic vessel" EXACT [] synonym: "lymph vessel endothelium" EXACT [] synonym: "lymphatic endothelium" EXACT [] synonym: "lymphatic vessel endothelium" EXACT [] is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0002046 name: thyroid gland def: "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." [] synonym: "glandula thyroidea" RELATED [] synonym: "thyroid" EXACT [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0007689 ! thyroid diverticulum relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0002048 name: lung def: "Respiration organ present in all air-breathing animals whose principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere[WP]. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax[GO]." [] synonym: "pulmo" EXACT [] is_a: UBERON:0000171 ! respiration organ is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005178 ! thoracic cavity organ relationship: develops_from UBERON:0000118 ! lung bud relationship: part_of UBERON:0000170 ! pair of lungs [Term] id: UBERON:0002049 name: vasculature def: "an interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." [] synonym: "vascular network" EXACT [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0007798 ! vascular system [Term] id: UBERON:0002050 name: embryonic structure def: "Anatomical structure that is part of an embryo." [] synonym: "developing embryonic structure" EXACT [] synonym: "developing structure" RELATED [] synonym: "embryonale Struktur" RELATED [] synonym: "embryonic anatomical structure" EXACT [] is_a: UBERON:0000061 ! anatomical structure is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0002051 name: epithelium of bronchiole def: "An epithelium that is part of a bronchiole [Automatically generated definition]." [] synonym: "bronchiolar epithelium" EXACT [] synonym: "bronchiole epithelial tissue" EXACT [] synonym: "bronchiole epithelium" EXACT [] synonym: "epithelial tissue of bronchiole" EXACT [] synonym: "epithelial tissue of lobular bronchiole" EXACT [] synonym: "epithelium of lobular bronchiole" EXACT [] synonym: "lobular bronchiole epithelial tissue" EXACT [] synonym: "lobular bronchiole epithelium" EXACT [] is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus is_a: UBERON:0003350 ! epithelium of mucosa intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002186 ! bronchiole relationship: part_of UBERON:0002186 ! bronchiole relationship: part_of UBERON:0005039 ! mucosa of bronchiole [Term] id: UBERON:0002053 name: zona glomerulosa of adrenal gland def: "The zona glomerulosa of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the adrenal gland's capsule. Its cells are ovoid in shape and are arranged in clusters or arches. In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system. Aldosterone regulates the body's concentration of electrolytes, primarily sodium and potassium, by acting on the distal convoluted tubule of kidney nephrons to: increase sodium reabsorption increase potassium excretion increase water reabsorption through osmosis The enzyme aldosterone synthase acts in this location. [WP,unvetted]." [] synonym: "adrenal gland zona glomerulosa" EXACT [] synonym: "glomerulosa" RELATED [] synonym: "zona glomerulosa" EXACT [] synonym: "zona glomerulosa of suprarenal gland" EXACT [] is_a: UBERON:0009753 ! adrenal gland cortex zone is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: UBERON:0002061 name: truncus arteriosus def: "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001637 ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0005432 ! aortic sac relationship: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0005498 ! primitive heart tube [Term] id: UBERON:0002066 name: umbilical vein def: "The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted]." [] synonym: "vena umbilicalis" RELATED [] is_a: UBERON:0001638 ! vein is_a: UBERON:0010260 ! umbilical blood vessel [Term] id: UBERON:0002067 name: dermis def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [] synonym: "corium" RELATED [] synonym: "cutis" RELATED [] synonym: "vertebrate dermis" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002199 ! integument [Term] id: UBERON:0002069 name: stratum granulosum of epidermis def: "A layer of the epidermis found between the stratum corneum (and possibly stratum lucidum) and stratum spinosum.[1] In this layer, keratinocytes are now called granular cells, and contain keratohyalin and lamellar granules." [] synonym: "epidermis granular layer" RELATED [] synonym: "epidermis stratum granulosum" EXACT [] synonym: "granular layer of epidermis" EXACT [] synonym: "stratum granulosum" EXACT [] is_a: UBERON:0013754 ! layer of skin relationship: part_of UBERON:0001003 ! epidermis [Term] id: UBERON:0002072 name: hypodermis def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [] synonym: "hypoderm" EXACT [] synonym: "sub-tegumental tissue" RELATED [] synonym: "subcutaneous tissue" RELATED [] synonym: "subcutis" RELATED [] synonym: "subtegumental tissue" RELATED [] synonym: "superficial fascia" RELATED [] synonym: "tela subcutanea" RELATED [] synonym: "vertebrate hypodermis" EXACT [] is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0002199 ! integument [Term] id: UBERON:0002073 name: hair follicle def: "a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]." [] synonym: "folliculus pili" RELATED [] is_a: UBERON:0000025 ! tube is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0005086 ! hair follicle placode relationship: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0011932 ! pilosebaceous unit [Term] id: UBERON:0002075 name: viscus def: "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. // An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper." [] synonym: "Organsystem@ge" RELATED [] synonym: "viscera" RELATED [] synonym: "visceral organ" EXACT [] synonym: "visceral organ system" EXACT [] is_a: UBERON:0005177 ! trunk organ relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0002080 name: heart right ventricle def: "Right cardiac chamber which is continuous with the pulmonary arterial trunk.[FMA]" [] synonym: "cardiac right ventricle" EXACT [] synonym: "right ventricle" EXACT [] synonym: "right ventricle of heart" EXACT [] synonym: "ventriculus dexter" RELATED [] is_a: UBERON:0002082 ! cardiac ventricle relationship: develops_from UBERON:0009889 ! secondary heart field [Term] id: UBERON:0002081 name: cardiac atrium def: "Cardiac chamber which consists of a wall that surrounds the cavity of an atrium.[FMA]" [] synonym: "atria" EXACT [] synonym: "atrial tissue" RELATED [] synonym: "atrium" EXACT [] synonym: "atrium of heart" EXACT [] synonym: "Cardiac atria" EXACT [] synonym: "cardiac atria" EXACT [] synonym: "heart atrium" EXACT [] is_a: UBERON:0004151 ! cardiac chamber relationship: develops_from UBERON:0010227 ! future cardiac atrium [Term] id: UBERON:0002082 name: cardiac ventricle def: "Cardiac chamber which consists of a wall that surrounds the cavity of a ventricle." [] synonym: "heart ventricle" EXACT [] synonym: "lower chamber of heart" EXACT [] synonym: "ventricle" BROAD [] synonym: "ventricle of heart" EXACT [] is_a: UBERON:0004151 ! cardiac chamber relationship: develops_from UBERON:0010226 ! future cardiac ventricle [Term] id: UBERON:0002084 name: heart left ventricle def: "Left cardiac chamber which is continuous with the aorta.[FMA]" [] synonym: "cardiac left ventricle" EXACT [] synonym: "left cardiac ventricle" EXACT [] synonym: "left ventricle" EXACT [] synonym: "left ventricle of heart" EXACT [] synonym: "ventriculus sinister cordis" RELATED [] is_a: UBERON:0002082 ! cardiac ventricle relationship: develops_from UBERON:0004140 ! primary heart field [Term] id: UBERON:0002085 name: interatrial septum def: "Cardiac septum which separates the right atrium from the left atrium.[FMA]" [] synonym: "atrial septum" EXACT [] synonym: "atrium septum" EXACT [] synonym: "interatrial septal wall" EXACT [] is_a: UBERON:0002099 ! cardiac septum [Term] id: UBERON:0002091 name: appendicular skeleton def: "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [] synonym: "appendicular skeleton" EXACT [] synonym: "entire appendicular skeleton" EXACT [] synonym: "paired fin skeleton" NARROW [] synonym: "skeleton appendiculare" RELATED [] is_a: UBERON:0010912 ! subdivision of skeleton relationship: part_of UBERON:0011249 ! appendicular skeletal system [Term] id: UBERON:0002092 name: brain dura mater def: "the fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer." [] synonym: "cranial dura mater" EXACT [] synonym: "dura mater encephali" EXACT [] synonym: "dura mater of brain" EXACT [] is_a: UBERON:0002363 ! dura mater is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0002093 name: spinal dura mater def: "A dura mater that is part of a spinal cord [Automatically generated definition]." [] synonym: "dura mater of neuraxis of spinal cord" EXACT [] synonym: "dura mater of spinal cord" EXACT [] synonym: "spinal cord dura mater" EXACT [] synonym: "spinal cord dura mater of neuraxis" EXACT [] is_a: UBERON:0002363 ! dura mater is_a: UBERON:0003292 ! meninx of spinal cord intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0002094 name: interventricular septum def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]" [] synonym: "heart interventricular septum" EXACT [] synonym: "heart ventricular septum" EXACT [] synonym: "interventricular septum of heart" RELATED [] synonym: "interventriculare cordis" RELATED [] synonym: "intraventricular septum" RELATED [] synonym: "s. interventriculare cordis" RELATED [] synonym: "septum inferius" RELATED [] synonym: "septum membranaceum" RELATED [] synonym: "ventricle septum" RELATED [] synonym: "ventricular septum" RELATED [] is_a: UBERON:0002099 ! cardiac septum [Term] id: UBERON:0002095 name: mesentery def: "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." [] synonym: "generic mesentery" EXACT [] synonym: "mesentery (generic)" EXACT [] is_a: UBERON:0000042 ! serous membrane relationship: develops_from UBERON:0002296 ! dorsal mesentery [Term] id: UBERON:0002097 name: skin of body def: "Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin[FMA]. Surface structure that consists of the external membranous integument of the animal." [] synonym: "entire skin" EXACT [] synonym: "integument" RELATED [] synonym: "pelt" RELATED [] synonym: "skin" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0011272 ! embryonic skin basal layer relationship: part_of UBERON:0002199 ! integument [Term] id: UBERON:0002099 name: cardiac septum def: "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." [] synonym: "cardiac septa" EXACT [] synonym: "heart septa" EXACT [] synonym: "heart septum" EXACT [] synonym: "septum of heart" EXACT [] is_a: UBERON:0003037 ! septum is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003037 ! septum intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0002100 name: trunk def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." [] synonym: "Rumpf" RELATED [] synonym: "thoracolumbar region" EXACT [] synonym: "torso" EXACT [] synonym: "trunk region" EXACT [] is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: part_of UBERON:0013702 ! body proper [Term] id: UBERON:0002104 name: visual system def: "The sensory system subserving the sense of vision." [] synonym: "photosensory system" EXACT [] synonym: "visual organ system" EXACT [] is_a: UBERON:0001032 ! sensory system [Term] id: UBERON:0002105 name: vestibulo-auditory system def: "A sensory system for the sense of hearing[WP]." [] synonym: "auditory organ system" EXACT [] synonym: "auditory system" RELATED [] synonym: "auditory/vestibular system" RELATED [] synonym: "vestibuloauditory system" EXACT [] synonym: "vestibuloauditory system" RELATED [] is_a: UBERON:0007037 ! mechanosensory system [Term] id: UBERON:0002106 name: spleen def: "Organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron. It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells." [] synonym: "lien" RELATED [] is_a: UBERON:0002075 ! viscus is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0005172 ! abdomen organ is_a: UBERON:0013765 ! digestive system organ relationship: develops_from UBERON:0006293 ! spleen primordium relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0002405 ! immune system [Term] id: UBERON:0002107 name: liver def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [] synonym: "iecur" RELATED [] synonym: "jecur" RELATED [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005172 ! abdomen organ is_a: UBERON:0006925 ! digestive gland relationship: develops_from UBERON:0003894 ! liver primordium relationship: develops_from UBERON:0004161 ! septum transversum relationship: develops_from UBERON:0008836 ! liver bud relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000949 ! endocrine system relationship: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0002330 ! exocrine system relationship: part_of UBERON:0002423 ! hepatobiliary system [Term] id: UBERON:0002108 name: small intestine def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." [] synonym: "anterior intestine" RELATED [] synonym: "intestinum tenue" RELATED [] synonym: "mid intestine" RELATED [] synonym: "small bowel" EXACT [] synonym: "small intestine" EXACT [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system organ relationship: part_of UBERON:0000160 ! intestine [Term] id: UBERON:0002110 name: gallbladder def: "a small organ that aids digestion and stores bile produced by the liver[WP]. Organ with organ cavity which is continuous proximally with the cystic duct and distally terminates in the fundus of the gallbladder[FMA]." [] synonym: "gall bladder" EXACT [] synonym: "vesica fellea; vesica biliaris" RELATED [] is_a: UBERON:0002075 ! viscus is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005172 ! abdomen organ is_a: UBERON:0013765 ! digestive system organ relationship: develops_from UBERON:0004912 ! biliary bud relationship: develops_from UBERON:0006242 ! gall bladder primordium relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0001173 ! biliary tree [Term] id: UBERON:0002111 name: artery smooth muscle tissue def: "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." [] synonym: "arterial smooth muscle" EXACT [] synonym: "arterial smooth muscle cell" RELATED [] synonym: "artery smooth muscle" EXACT [] synonym: "artery smooth muscle tissue" EXACT [] synonym: "smooth muscle of artery" EXACT [] is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0002112 name: smooth muscle of esophagus def: "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." [] synonym: "esophageal smooth muscle" EXACT [] synonym: "esophagus involuntary muscle" EXACT [] synonym: "esophagus non-striated muscle" EXACT [] synonym: "esophagus smooth muscle" EXACT [] synonym: "esophagus smooth muscle tissue" EXACT [] synonym: "gullet involuntary muscle" EXACT [] synonym: "gullet non-striated muscle" EXACT [] synonym: "gullet smooth muscle" EXACT [] synonym: "gullet smooth muscle tissue" EXACT [] synonym: "involuntary muscle of esophagus" EXACT [] synonym: "involuntary muscle of gullet" EXACT [] synonym: "involuntary muscle of oesophagus" EXACT [] synonym: "non-striated muscle of esophagus" EXACT [] synonym: "non-striated muscle of gullet" EXACT [] synonym: "non-striated muscle of oesophagus" EXACT [] synonym: "oesophagus involuntary muscle" EXACT [] synonym: "oesophagus non-striated muscle" EXACT [] synonym: "oesophagus smooth muscle" RELATED [] synonym: "oesophagus smooth muscle tissue" EXACT [] synonym: "smooth muscle of gullet" EXACT [] synonym: "smooth muscle of oesophagus" EXACT [] synonym: "smooth muscle tissue of esophagus" EXACT [] synonym: "smooth muscle tissue of gullet" EXACT [] synonym: "smooth muscle tissue of oesophagus" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0003832 ! esophagus muscle [Term] id: UBERON:0002113 name: kidney def: "A paired organ which has the production of urine as its primary function." [] synonym: "reniculate kidney" NARROW [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0005172 ! abdomen organ is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0003918 ! kidney mesenchyme relationship: develops_from UBERON:0005095 ! kidney rudiment relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0011143 ! upper urinary tract [Term] id: UBERON:0002114 name: duodenum def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." [] synonym: "proximal intestine" RELATED [] synonym: "upper intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0002115 name: jejunum def: "The jejunum is the middle section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms middle intestine or mid-gut may be used instead of jejunum. [WP,unvetted]." [] synonym: "intestinum jejunum" RELATED [] synonym: "middle intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: develops_from UBERON:0001045 ! midgut relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0002116 name: ileum def: "The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine may be used instead of ileum. [WP,unvetted]." [] synonym: "distal intestine" RELATED [] synonym: "intestinum ileum" RELATED [] synonym: "lower intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0002118 name: right ovary def: "An ovary that is part of a right side of organism [Automatically generated definition]." [] is_a: UBERON:0000992 ! female gonad [Term] id: UBERON:0002119 name: left ovary def: "An ovary that is part of a left side of organism [Automatically generated definition]." [] is_a: UBERON:0000992 ! female gonad [Term] id: UBERON:0002120 name: pronephros def: "In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO]." [] synonym: "archinephron" RELATED [] synonym: "embryonic kidney" RELATED [] synonym: "pronephric kidney" EXACT [] synonym: "pronephron" RELATED [] is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0005095 ! kidney rudiment relationship: develops_from UBERON:0005721 ! pronephric mesoderm relationship: develops_from UBERON:0005754 ! rostral part of nephrogenic cord [Term] id: UBERON:0002123 name: cortex of thymus def: "Cortical portion of thymus, mainly composed of lymphoid cells, supported by a network of finely-branched epithelial reticular cells, which is continuous with a similar network in the medullary portion. This network forms an adventitia to the blood vessels. The cortex is the location of the earliest events in thymocyte development, where T cell receptor gene rearrangement and positive selection takes place." [] synonym: "thymic cortex" EXACT [] synonym: "thymus cortex" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001851 ! cortex intersection_of: UBERON:0001851 ! cortex intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0002124 name: medulla of thymus def: "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." [] synonym: "medulla of thymus gland" EXACT [] synonym: "thymus gland medulla" EXACT [] synonym: "thymus medulla" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000958 ! medulla intersection_of: UBERON:0000958 ! medulla intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0002129 name: cerebellar cortex def: "The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer." [] synonym: "cell bridges of the ventral striatum" RELATED [] synonym: "cortex cerebellaris" RELATED [] synonym: "cortex cerebelli" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002037 ! cerebellum [Term] id: UBERON:0002165 name: endocardium def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber[FMA]." [] synonym: "endocardial tissue" EXACT [] synonym: "heart endocardial tissue" RELATED [] synonym: "heart endocardium" EXACT [] is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0005983 ! heart layer relationship: develops_from UBERON:0003084 ! heart primordium relationship: develops_from UBERON:0007280 ! presumptive endocardium relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0002166 name: endocardium of atrium def: "Endocardium that is part of the atrium." [] synonym: "atrial endocardium" EXACT [] synonym: "atrium endocardial tissue" RELATED [] synonym: "atrium endocardium" EXACT [] synonym: "atrium of heart endocardium" EXACT [] synonym: "Cardiac atria endocardium" EXACT [] synonym: "cardiac atrium endocardium" EXACT [] synonym: "endocardium of atrium of heart" EXACT [] synonym: "endocardium of Cardiac atria" EXACT [] synonym: "endocardium of cardiac atrium" EXACT [] synonym: "endocardium of heart atrium" EXACT [] synonym: "heart atrium endocardium" EXACT [] is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002169 name: alveolar sac def: "the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [] synonym: "air sac" RELATED [] synonym: "pulmonary alveolar sac" EXACT [] synonym: "sacculus alveolaris" EXACT [] is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000117 ! respiratory tube is_a: UBERON:0007499 ! epithelial sac intersection_of: UBERON:0007499 ! epithelial sac intersection_of: part_of UBERON:0008874 ! pulmonary acinus relationship: part_of UBERON:0006524 ! alveolar system relationship: part_of UBERON:0008874 ! pulmonary acinus [Term] id: UBERON:0002185 name: bronchus def: "A portion of the airway that connects to the lungs[GO]." [] synonym: "bronchi" EXACT [] synonym: "bronchial tissue" RELATED [] synonym: "bronchial trunk" EXACT [] is_a: UBERON:0000117 ! respiratory tube relationship: part_of UBERON:0007196 ! tracheobronchial tree [Term] id: UBERON:0002186 name: bronchiole def: "the first airway branch that no longer contains cartilage; it is a branch of the bronchus[GO]." [] synonym: "bronchioli" RELATED [] synonym: "bronchiolus" RELATED [] synonym: "lobular bronchiole" EXACT [] is_a: UBERON:0000117 ! respiratory tube relationship: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0010368 ! pulmonary lobule [Term] id: UBERON:0002187 name: terminal bronchiole def: "A terminal bronchiole is a bronchiole at the end of the conducting zone. At the transition into the respiratory zone, alveoli become present. The terminal bronchiole is the most distal segment of the conducting zone. Each of the terminal bronchioles divides to form respiratory bronchioles which contain a small number of alveoli. Terminal bronchioles are lined with simple cuboidal epithelium containing Clara cells. Terminal bronchioles contain a limited number of ciliated cells and no goblet cells. Clara cells are non-ciliated, rounded protein secreting cells. Their secretions are a nonsticky, proteinaceous compound to maintain the airway in the smallest bronchioles. The secretion, called surfactant, reduces surface tension allowing for bronchioles to expand during inspiration and keeping the bronchioles from collapsing during expiration. Clara cells, a stem cell of the respiratory system, produce enzymes that detoxify substances dissolved in the respiratory fluid. [WP,unvetted]." [] synonym: "bronchioli terminalis" RELATED [] synonym: "bronchiolus terminalis" EXACT [] synonym: "terminal bronchiole tube" RELATED [] is_a: UBERON:0002186 ! bronchiole [Term] id: UBERON:0002188 name: respiratory bronchiole def: "A bronchiole that is the first segment of the respiratory zone." [] synonym: "bronchiolus respiratorii" EXACT [] synonym: "bronchiolus respiratorius" EXACT [] is_a: UBERON:0002186 ! bronchiole relationship: part_of UBERON:0008874 ! pulmonary acinus [Term] id: UBERON:0002190 name: subcutaneous adipose tissue def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." [] synonym: "fatty layer of subcutaneous tissue" EXACT [] synonym: "hypodermis fat layer" EXACT [] synonym: "panniculus adiposus" BROAD [] synonym: "panniculus adiposus (tela subcutanea)" EXACT [] synonym: "panniculus adiposus telae subcutaneae" EXACT [] synonym: "subcutaneous fat" RELATED [] synonym: "subcutaneous fat layer" EXACT [] is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis [Term] id: UBERON:0002193 name: hemolymphoid system def: "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." [] synonym: "haemolymphoid system" RELATED [] synonym: "hematolymphoid system" EXACT [] synonym: "lymphomyeloid complex" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0002194 name: capsule of lymph node def: "Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers. from its internal surface are given off a number of membranous processes or trabeculae, consisting, in man, of connective tissue, with a small admixture of plain muscle fibers; but in many of the lower animals composed almost entirely of involuntary muscle[WP]." [] synonym: "lymph node capsule" EXACT [] is_a: UBERON:0003893 ! capsule [Term] id: UBERON:0002196 name: adenohypophysis def: "The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA]." [] synonym: "AHP" BROAD [] synonym: "anterior hypophysis" EXACT [] synonym: "anterior hypothalamic area posterior part" RELATED [] synonym: "anterior hypothalamic area, posterior part" RELATED [] synonym: "anterior lobe (hypophysis)" EXACT [] synonym: "anterior lobe of hypophysis" EXACT [] synonym: "anterior lobe of pituitary" EXACT [] synonym: "anterior lobe of pituitary gland" EXACT [] synonym: "anterior lobe of the pituitary" RELATED [] synonym: "anterior pituitary" EXACT [] synonym: "anterior pituitary gland" RELATED [] synonym: "cranial lobe" RELATED [] synonym: "lobus anterior" RELATED [] synonym: "lobus anterior (glandula pituitaria)" EXACT [] synonym: "lobus anterior hypophysis" EXACT [] synonym: "nucleus ansae lenticularis" RELATED [] synonym: "nucleus of ansa lenticularis" RELATED [] synonym: "nucleus of the ansa lenticularis" RELATED [] synonym: "pituitary gland, anterior lobe" EXACT [] synonym: "pituitary glandanterior lobe" RELATED [] synonym: "rostral lobe" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0009122 ! adenohypophyseal placode relationship: part_of UBERON:0000007 ! pituitary gland [Term] id: UBERON:0002199 name: integument def: "The dermis, epidermis and hypodermis." [] synonym: "dermal system" RELATED [] synonym: "dermoid system" RELATED [] synonym: "Hautsystem" RELATED [] synonym: "integumentum commune" EXACT [] synonym: "skin" RELATED [] synonym: "tegument" RELATED [] synonym: "the integument" EXACT [] is_a: UBERON:0003102 ! surface structure relationship: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0002200 name: vasculature of head def: "Vasculature that is part of a head [Automatically generated definition]." [] synonym: "adult head vascular network" EXACT [] synonym: "adult head vasculature" EXACT [] synonym: "cranial vasculature" EXACT [] synonym: "head vascular network" EXACT [] synonym: "head vasculature" RELATED [] synonym: "vascular network of adult head" EXACT [] synonym: "vascular network of head" EXACT [] synonym: "vasculature of adult head" EXACT [] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0002201 name: vasculature of trunk def: "A vasculature that is part of a trunk [Automatically generated definition]." [] synonym: "torso vascular network" EXACT [] synonym: "torso vasculature" EXACT [] synonym: "trunk vascular network" EXACT [] synonym: "trunk vasculature" EXACT [] synonym: "vascular network of torso" EXACT [] synonym: "vascular network of trunk" EXACT [] synonym: "vasculature of torso" EXACT [] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0002202 name: submucosa of trachea def: "A submucosa that is part of a trachea." [] synonym: "submucosa of windpipe" EXACT [] synonym: "submucous layer of trachea" RELATED [] synonym: "trachea submucosa" EXACT [] synonym: "tracheal submucosa" EXACT [] synonym: "windpipe submucosa" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0002203 name: vasculature of eye def: "Vasculature that is part of the eye region." [] synonym: "eye vascular network" EXACT [] synonym: "eye vasculature" RELATED [] synonym: "ocular blood vessel" EXACT [] synonym: "ocular vasculature" EXACT [] synonym: "optic vasculature" RELATED [] synonym: "vascular network of eye" EXACT [] is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0002204 name: musculoskeletal system def: "Anatomical system that consists of the muscular and skeletal systems." [] synonym: "musculo-skeletal system" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0002209 name: fibrous joint def: "Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA]" [] synonym: "articulatio fibrosa" EXACT [] synonym: "junctura fibrosa" RELATED [] is_a: UBERON:0011134 ! nonsynovial joint [Term] id: UBERON:0002211 name: nerve root def: "The initial segment of a nerve leaving the central nervous system (Wikipedia)." [] synonym: "radix nervi" EXACT [] is_a: UBERON:0000122 ! neuron projection bundle [Term] id: UBERON:0002212 name: macula of saccule of membranous labyrinth def: "The saccule is the smaller of the two vestibular sacs; it is globular in form, and lies in the recessus sphricus near the opening of the scala vestibuli of the cochlea. Its anterior part exhibits an oval thickening, the macula of saccule (or saccular macula), to which are distributed the saccular filaments of the acoustic nerve. [WP,unvetted]." [] synonym: "macula of membranous labyrinth saccule" EXACT [] synonym: "macula of saccule" EXACT [] synonym: "macula of sacculus (labyrinthus vestibularis)" EXACT [] synonym: "macula saccule" EXACT [] synonym: "macula sacculi" EXACT [] synonym: "macula sacculi" RELATED [] synonym: "membranous labyrinth saccule macula" EXACT [] synonym: "saccular macula" EXACT [] synonym: "saccular macula of membranous labyrinth" EXACT [] synonym: "saccular maculs" RELATED [] synonym: "saccule macula" EXACT [] synonym: "saccule of membranous labyrinth macula" EXACT [] synonym: "sacculus (labyrinthus vestibularis) macula" EXACT [] is_a: UBERON:0000054 ! macula intersection_of: UBERON:0000054 ! macula intersection_of: part_of UBERON:0001854 ! saccule of membranous labyrinth relationship: part_of UBERON:0001854 ! saccule of membranous labyrinth [Term] id: UBERON:0002213 name: cartilaginous joint def: "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]" [] synonym: "articulatio cartilaginea" EXACT [] synonym: "junctura cartilaginea" RELATED [] is_a: UBERON:0011134 ! nonsynovial joint [Term] id: UBERON:0002214 name: macula of utricle of membranous labyrinth def: "The portion of the utricle which is lodged in the recess forms a sort of pouch or cul-de-sac, the floor and anterior wall of which are thickened, and form the macula of utricle (or utricular macula), which receives the utricular filaments of the vestibulocochlear nerve. [WP,unvetted]." [] synonym: "macula of membranous labyrinth utricle" EXACT [] synonym: "macula of utricle" EXACT [] synonym: "macula of utriculus (labyrinthus vestibularis)" EXACT [] synonym: "macula utricle" EXACT [] synonym: "macula utriculi" EXACT [] synonym: "macula utriculi" RELATED [] synonym: "membranous labyrinth utricle macula" EXACT [] synonym: "utricle macula" EXACT [] synonym: "utricle of membranous labyrinth macula" EXACT [] synonym: "utricular macula" RELATED [] synonym: "utriculus (labyrinthus vestibularis) macula" EXACT [] is_a: UBERON:0000054 ! macula intersection_of: UBERON:0000054 ! macula intersection_of: part_of UBERON:0001853 ! utricle of membranous labyrinth relationship: part_of UBERON:0001853 ! utricle of membranous labyrinth [Term] id: UBERON:0002216 name: symphysis def: "Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA]" [] synonym: "secondary cartilaginous joint" EXACT [] is_a: UBERON:0002209 ! fibrous joint is_a: UBERON:0002213 ! cartilaginous joint [Term] id: UBERON:0002217 name: synovial joint def: "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]" [] synonym: "articulatio synoviale" EXACT [] synonym: "diarthrodial joints" RELATED [] synonym: "diarthroses" EXACT [] synonym: "diarthrosis" EXACT [] synonym: "diarthrosis joint" EXACT [] is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0002227 name: spiral organ of cochlea def: "The organ of Corti (or spiral organ) is the organ in the inner ear of mammals that contains auditory sensory cells, or 'hair cells.' [WP,unvetted]." [] synonym: "basilar papilla" RELATED [] synonym: "cochlear spiral organ" EXACT [] synonym: "Corti's organ" RELATED [] synonym: "organ of Corti" RELATED [] synonym: "organum spirale" EXACT [] synonym: "papilla basilaris" RELATED [] synonym: "spiral organ" EXACT [] synonym: "spiral organ of Corti" EXACT [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth [Term] id: UBERON:0002240 name: spinal cord def: "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)" [] synonym: "cerebro-cerebellar fissure" RELATED [] synonym: "cerebrocerebellar fissure" RELATED [] synonym: "fissura cerebro-cerebellaris" RELATED [] synonym: "fissura cerebrocerebellaris" RELATED [] synonym: "medulla spinalis" RELATED [] synonym: "spinal cord structure" RELATED [] synonym: "spinal medulla" RELATED [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005174 ! dorsal region organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003076 ! posterior neural tube relationship: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0002241 name: chondrocranium def: "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." [] synonym: "calvarium" RELATED [] synonym: "neurocranium" RELATED [] is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system [Term] id: UBERON:0002242 name: nucleus pulposus def: "a jelly-like connective tissue in the middle of the spinal disc. It is the remnant of the notochord. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[WP]." [] synonym: "nucleus propulsus" RELATED [] synonym: "nucleus propulsus of intervertebral disk" RELATED [] synonym: "nucleus pulposus (diskus intervertebralis)" EXACT [] synonym: "nucleus pulposus of intervertebral disk" RELATED [] synonym: "pulpy nucleus" EXACT [] is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0002328 ! notochord relationship: part_of UBERON:0001066 ! intervertebral disk [Term] id: UBERON:0002255 name: vomeronasal organ def: "The vomeronasal organ (VNO), or Jacobson's organ, is an auxiliary olfactory sense organ that is found in many animals. It was discovered by Ludwig Jacobson in 1813. During embryological development, it forms from the nasal (olfactory) placode, at the anterior edge of the neural plate. It is a chemoreceptor organ which is completely separated from the nasal cavity the majority of the time, being enclosed in a separate bony or cartilaginous capsule which opens into the base of the nasal cavity. It is a tubular crescent shape and split into two pairs, separated by the nasal septum. It is the first processing stage of the accessory olfactory system, after which chemical stimuli go to the accessory olfactory bulb, then to targets in the amygdala and hypothalamus. The vomeronasal organ is mainly used to detect pheromones, chemical messengers that carry information between individuals of the same species, hence is sometimes referred to as the 'sixth sense. ' The VNO has two separate types of neuronal receptors, V1R and V2R, which are seven-transmembrane receptors that are coupled to G proteins. The receptors are distinct from each other and form the large family of receptors in the main olfactory system. Evidence shows that the VNO responds to nonvolatile cues which stimulate the receptor neurons. Information is then transferred to the accessory olfactory bulb as well as other centres of the brain such as the anterior part of the hypothalamus. Its presence in many animals has been widely studied and the importance of the vomeronasal system to the role of reproduction and social behavior (through influence on anterior hypothalamus) has been shown in many studies. Its presence and functionality in humans is widely controversial, though most studies agree the organ regresses during fetal development. [WP,unvetted]." [] synonym: "Jacobson's organ" EXACT [] synonym: "organ of Jacobsen" RELATED [] synonym: "organon vomeronasale" EXACT [] synonym: "organum vomeronasale" EXACT [] synonym: "organum vomeronasale" RELATED [] synonym: "VNO" RELATED [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0003050 ! olfactory placode relationship: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0009954 ! vomeronasal system [Term] id: UBERON:0002256 name: dorsal horn of spinal cord def: "the pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord[MP]. the dorsal (more towards the back) grey matter of the spinal cord. It receives several types of sensory information from the body, including light touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion[WP]. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input[GO]." [] synonym: "cornu dorsale" EXACT [] synonym: "cornu posterius medullae spinalis" EXACT [] synonym: "dorsal gray column of spinal cord" EXACT [] synonym: "dorsal gray horn" EXACT [] synonym: "dorsal gray matter of spinal cord" EXACT [] synonym: "dorsal grey column of spinal cord" EXACT [] synonym: "dorsal grey horn" BROAD [] synonym: "dorsal horn" BROAD [] synonym: "dorsal horn of the spinal cord" RELATED [] synonym: "dorsal horn spinal cord" EXACT [] synonym: "dorsal region of mature spinal cord" BROAD [] synonym: "dorsal region of spinal cord" BROAD [] synonym: "dorsal spinal cord" BROAD [] synonym: "posterior gray column of spinal cord" EXACT [] synonym: "posterior gray horn of spinal cord" EXACT [] synonym: "posterior grey column of spinal cord" EXACT [] synonym: "posterior horn of spinal cord" EXACT [] synonym: "spinal cord dorsal horn" EXACT [] synonym: "spinal cord dorsal horns" RELATED [] synonym: "spinal cord posterior horn" EXACT [] is_a: UBERON:0001948 ! regional part of spinal cord relationship: part_of UBERON:0002315 ! gray matter of spinal cord [Term] id: UBERON:0002257 name: ventral horn of spinal cord def: "the ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." [] synonym: "anterior column" RELATED [] synonym: "anterior column of the spinal cord" RELATED [] synonym: "anterior gray column of spinal cord" EXACT [] synonym: "anterior gray horn of spinal cord" EXACT [] synonym: "anterior grey column of spinal cord" EXACT [] synonym: "anterior horn" EXACT [] synonym: "anterior horn (spinal cord)" RELATED [] synonym: "cornu anterius medullae spinalis" RELATED [] synonym: "spinal cord anterior horn" EXACT [] synonym: "spinal cord ventral horn" EXACT [] synonym: "ventral gray column of spinal cord" EXACT [] synonym: "ventral gray matter of spinal cord" EXACT [] synonym: "ventral grey column of spinal cord" EXACT [] synonym: "ventral grey horn" EXACT [] synonym: "ventral horn of the spinal cord" RELATED [] synonym: "ventral horn spinal cord" EXACT [] synonym: "ventral horns spinal cord" RELATED [] synonym: "ventral region of spinal cord" EXACT [] synonym: "ventral spinal cord" EXACT [] is_a: UBERON:0001948 ! regional part of spinal cord relationship: part_of UBERON:0002315 ! gray matter of spinal cord [Term] id: UBERON:0002261 name: dorsal root of spinal cord def: "The dorsal roots contain afferent sensory axons. The dorsal roots of each side continue outwards, along the way forming a dorsal root ganglion (also called a spinal ganglion)." [] synonym: "dorsal root" EXACT [] synonym: "dorsal root of spinal nerve" EXACT [] synonym: "dorsal roots" RELATED [] synonym: "dorsal spinal nerve root" EXACT [] synonym: "dorsal spinal root" EXACT [] synonym: "posterior root of spinal nerve" EXACT [] synonym: "radix dorsalis" EXACT [] synonym: "radix posterior" RELATED [] synonym: "radix posterior (nervus spinalis)" EXACT [] synonym: "radix posterior nervi spinalis" RELATED [] synonym: "radix sensoria (nervus spinalis)" EXACT [] synonym: "root dorsali nervi spinalis" RELATED [] synonym: "root sensoria nervi spinalis" RELATED [] synonym: "sensory root of spinal nerve" EXACT [] synonym: "sensory spinal root" RELATED [] is_a: UBERON:0009623 ! spinal nerve root [Term] id: UBERON:0002264 name: olfactory bulb def: "A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]. Segment of neural tree organ which is continuous with a set of olfactory nerves and an olfactory tract. In most vertebrates, the olfactory bulb is the most rostral (forward) part of the brain. In humans, however, the olfactory bulb is on the inferior (bottom) side of the brain. The olfactory bulb is supported and protected by the cribriform plate which in mammals, separates it from the olfactory epithelium, and which is perforated by olfactory nerve axons. The bulb is divided into two distinct structures, the main olfactory bulb, and the accessory olfactory bulb[WP]." [] synonym: "bulbus olfactorius" EXACT [] synonym: "bulbus olfactorius" RELATED [] synonym: "bulbus olfactorius (Morgagni)" RELATED [] synonym: "olfactory forebrain" RELATED [] synonym: "olfactory lobe" RELATED [] synonym: "olfactory lobe (Barr & Kiernan)" RELATED [] is_a: UBERON:0002791 ! regional part of telencephalon relationship: part_of UBERON:0005366 ! olfactory lobe [Term] id: UBERON:0002268 name: olfactory organ synonym: "olfactory neuroepithelium" RELATED [] synonym: "organ olfactus" RELATED [] synonym: "organum olfactorium" RELATED [] is_a: UBERON:0000020 ! sense organ [Term] id: UBERON:0002271 name: periventricular zone of hypothalamus synonym: "hypothalamus periventricular zone" EXACT [] synonym: "Periventricular zone of the hypothalamus" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001898 ! hypothalamus [Term] id: UBERON:0002275 name: reticular formation is_a: UBERON:0000073 ! regional part of nervous system [Term] id: UBERON:0002276 name: lamina of spiral limbus def: "The osseous spiral lamina consists of two plates of bone, and between these are the canals for the transmission of the filaments of the acoustic nerve. On the upper plate of that part of the lamina which is outside the vestibular membrane, the periosteum is thickened to form the limbus spiralis (or limbus lamin spiralis), this ends externally in a concavity, the sulcus spiralis internus, which represents, on section, the form of the letter C. [WP,unvetted]." [] synonym: "limbus lamina spiralis" EXACT [] synonym: "limbus laminae spiralis" EXACT [] synonym: "limbus laminae spiralis osseae" EXACT [] synonym: "spiral limbus" RELATED [] synonym: "spiral limbus lamina" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth [Term] id: UBERON:0002282 name: stria vascularis of cochlear duct def: "The upper portion of the spiral ligament contains numerous capillary loops and small blood vessels, and is termed the stria vascularis. It produces endolymph for the scala media, one of the three fluid-filled compartments of the cochlea. [WP,unvetted]." [] synonym: "psalterial cord" EXACT [] synonym: "stria vascularis" EXACT [] synonym: "stria vascularis ductus cochlearis" RELATED [] synonym: "stria vascularis of cochlea" EXACT [] synonym: "vascular stria of cochlear duct" RELATED [] synonym: "vascular stripe of cochlear duct" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth [Term] id: UBERON:0002285 name: telencephalic ventricle def: "A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere" [] synonym: "forebrain ventricle" RELATED [] synonym: "lateral ventricle" EXACT [] synonym: "lateral ventricle of brain" RELATED [] synonym: "Motor nucleus of trigeminal" RELATED [] synonym: "tectal ventricle" RELATED [] synonym: "telencephalic ventricle" EXACT [] synonym: "Telencephalic ventricles" RELATED [] synonym: "telencephalic vesicle" RELATED [] synonym: "telencephalon lateral ventricle" EXACT [] synonym: "ventrolateral complex" RELATED [] is_a: UBERON:0004086 ! brain ventricle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0004086 ! brain ventricle intersection_of: part_of UBERON:0001893 ! telencephalon relationship: develops_from UBERON:0009676 ! early telencephalic vesicle relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0002290 name: choroid plexus of fourth ventricle def: "A choroid plexus that is part of a fourth ventricle [Automatically generated definition]." [] synonym: "4th ventricle choroid plexus" RELATED [] synonym: "chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT [] synonym: "chorioid plexus of fourth ventricle" EXACT [] synonym: "choroid plexus fourth ventricle" EXACT [] synonym: "fourth ventricle chorioid plexus of cerebral hemisphere" EXACT [] synonym: "fourth ventricle choroid plexus" EXACT [] is_a: UBERON:0001886 ! choroid plexus is_a: UBERON:0006694 ! cerebellum vasculature intersection_of: UBERON:0001886 ! choroid plexus intersection_of: part_of UBERON:0002422 ! fourth ventricle relationship: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002422 ! fourth ventricle [Term] id: UBERON:0002291 name: central canal of spinal cord def: "Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [] synonym: "canalis centralis" EXACT [] synonym: "central canal" EXACT [] synonym: "central canal of spinal cord" EXACT [] synonym: "central canal, spinal cord/medulla" RELATED [] synonym: "neural lumen" RELATED [] synonym: "spinal cord central canal" EXACT [] synonym: "ventricle of spinal cord" EXACT [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0001049 ! neural tube relationship: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0005281 ! ventricular system of central nervous system [Term] id: UBERON:0002294 name: biliary system def: "Anatomical system that consists of the organs and ducts (bile ducts, gallbladder, and associated structures) that are involved in the production and transportation of bile." [] synonym: "biliary apparatus" EXACT [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0002423 ! hepatobiliary system [Term] id: UBERON:0002296 name: dorsal mesentery def: "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]." [] synonym: "dorsal mesogastrium" RELATED [] synonym: "mesenterium dorsale commune" RELATED [] is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0009664 ! gut mesentery [Term] id: UBERON:0002298 name: brainstem def: "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." [] synonym: "accessory medullary lamina of pallidum" RELATED [] synonym: "brain stem" EXACT [] synonym: "lamella pallidi incompleta" RELATED [] synonym: "lamina medullaris accessoria" RELATED [] synonym: "lamina medullaris incompleta pallidi" RELATED [] synonym: "lamina pallidi incompleta" RELATED [] synonym: "truncus encephali" EXACT [] synonym: "truncus encephalicus" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0002299 name: alveolus of lung def: "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." [] synonym: "alveoli" RELATED [] synonym: "alveolus" BROAD [] synonym: "alveolus pulmonis" EXACT [] synonym: "alveolus pulmonis" RELATED [] synonym: "lung alveolus" EXACT [] synonym: "pulmonary alveolus" EXACT [] synonym: "respiratory alveoli" RELATED [] synonym: "respiratory alveolus" EXACT [] is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0003215 ! alveolus intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002169 ! alveolar sac relationship: part_of UBERON:0006524 ! alveolar system [Term] id: UBERON:0002302 name: myocardium of atrium def: "A myocardium that is part of a cardiac atrium [Automatically generated definition]." [] synonym: "atrial myocardium" EXACT [] synonym: "atrium cardiac muscle" RELATED [] synonym: "atrium myocardium" EXACT [] synonym: "atrium of heart cardiac muscle" EXACT [] synonym: "atrium of heart heart muscle" EXACT [] synonym: "atrium of heart heart myocardium" EXACT [] synonym: "atrium of heart muscle of heart" EXACT [] synonym: "atrium of heart myocardium" EXACT [] synonym: "Cardiac atria cardiac muscle" EXACT [] synonym: "Cardiac atria heart muscle" EXACT [] synonym: "Cardiac atria heart myocardium" EXACT [] synonym: "Cardiac atria muscle of heart" EXACT [] synonym: "Cardiac atria myocardium" EXACT [] synonym: "cardiac atrium cardiac muscle" EXACT [] synonym: "cardiac atrium heart muscle" EXACT [] synonym: "cardiac atrium heart myocardium" EXACT [] synonym: "cardiac atrium muscle of heart" EXACT [] synonym: "cardiac atrium myocardium" EXACT [] synonym: "cardiac muscle of atrium of heart" EXACT [] synonym: "cardiac muscle of Cardiac atria" EXACT [] synonym: "cardiac muscle of cardiac atrium" EXACT [] synonym: "cardiac muscle of heart atrium" EXACT [] synonym: "heart atrium cardiac muscle" EXACT [] synonym: "heart atrium heart muscle" EXACT [] synonym: "heart atrium heart myocardium" EXACT [] synonym: "heart atrium muscle of heart" EXACT [] synonym: "heart atrium myocardium" EXACT [] synonym: "heart muscle of atrium of heart" EXACT [] synonym: "heart muscle of Cardiac atria" EXACT [] synonym: "heart muscle of cardiac atrium" EXACT [] synonym: "heart muscle of heart atrium" EXACT [] synonym: "heart myocardium of atrium of heart" EXACT [] synonym: "heart myocardium of Cardiac atria" EXACT [] synonym: "heart myocardium of cardiac atrium" EXACT [] synonym: "heart myocardium of heart atrium" EXACT [] synonym: "muscle of heart of atrium of heart" EXACT [] synonym: "muscle of heart of Cardiac atria" EXACT [] synonym: "muscle of heart of cardiac atrium" EXACT [] synonym: "muscle of heart of heart atrium" EXACT [] synonym: "myocardium of atrium of heart" EXACT [] synonym: "myocardium of Cardiac atria" EXACT [] synonym: "myocardium of cardiac atrium" EXACT [] synonym: "myocardium of heart atrium" EXACT [] is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002303 name: juxtaglomerular apparatus def: "An anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]. a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus: it is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP]." [] synonym: "complexus juxtaglomerularis" RELATED [] synonym: "juxtaglomerular complex" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0002305 name: layer of hippocampus def: "the layers of the laminar structure of the hippocampus." [] synonym: "cytoarchitectural fields of hippocampal formation" EXACT [] synonym: "hippocampus layer" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: UBERON:0002307 name: choroid plexus of lateral ventricle def: "A choroid plexus that is part of a lateral ventricle [Automatically generated definition]." [] synonym: "chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT [] synonym: "chorioid plexus of lateral ventricle" EXACT [] synonym: "choroid plexus telencephalic ventricle" EXACT [] synonym: "lateral ventricle chorioid plexus of cerebral hemisphere" EXACT [] synonym: "lateral ventricle choroid plexus" EXACT [] is_a: UBERON:0001886 ! choroid plexus is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001886 ! choroid plexus intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: UBERON:0002308 name: nucleus of brain def: "Nucleus of neuraxis which is located within the brain. Example: pontobulbar nucleus, globose nucleus[FMA]. brain structure consisting of a relatively compact cluster of neurons. It is one of the two most common forms of nerve cell organization, the other being layered structures such as the cerebral cortex or cerebellar cortex. In anatomical sections, a nucleus shows up as a region of gray matter, often bordered by white matter. The vertebrate brain contains hundreds of distinguishable nuclei, varying widely in shape and size. A nucleus may itself have a complex internal structure, with multiple types of neurons arranged in clumps (subnuclei) or layers.[Wikipedia]" [] synonym: "brain nucleus" EXACT [] is_a: UBERON:0000125 ! neural nucleus is_a: UBERON:0002616 ! regional part of brain intersection_of: UBERON:0000125 ! neural nucleus intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0003528 ! brain grey matter [Term] id: UBERON:0002313 name: hippocampus pyramidal layer def: "A cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. Its location is superficial to the Stratum oriens; it is deep to the Stratum radiatum in area CA1 and area CA2 and deep to the Stratum lucidum in area CA3 (Stephan-75) (NeuroNames)." [] synonym: "gyrus occipitalis inferior" RELATED [] synonym: "gyrus occipitalis tertius" RELATED [] synonym: "hippocampal pyramidal cell layer" RELATED [] synonym: "hippocampal pyramidal layer" RELATED [] synonym: "hippocampus pyramidal cell layer" RELATED [] synonym: "hippocampus stratum pyramidale" RELATED [] synonym: "pyramidal cell layer of the hippocampus" EXACT [] synonym: "pyramidal layer of hippocampus" EXACT [] synonym: "stratum pyramidale" EXACT [] synonym: "stratum pyramidale hippocampi" EXACT [] is_a: UBERON:0002305 ! layer of hippocampus [Term] id: UBERON:0002315 name: gray matter of spinal cord def: "the ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." [] synonym: "gray matter of neuraxis of spinal cord" EXACT [] synonym: "gray substance of spinal cord" EXACT [] synonym: "grey matter of spinal cord" EXACT [] synonym: "grey substance of spinal cord" EXACT [] synonym: "spinal cord gray matter" EXACT [] synonym: "spinal cord gray matter of neuraxis" EXACT [] synonym: "spinal cord grey matter" EXACT [] synonym: "spinal cord grey substance" EXACT [] is_a: UBERON:0002020 ! gray matter of neuraxis intersection_of: UBERON:0002020 ! gray matter of neuraxis intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0002319 name: mesangium def: "inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries." [] is_a: UBERON:0003567 ! abdomen connective tissue is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0005215 ! kidney interstitium [Term] id: UBERON:0002320 name: glomerular mesangium def: "A thin membrane which helps to support the capillary loops in a renal glomerulus. It is connective tissue composed of mesangial cells - myofibroblasts phenotypically related to vascular smooth muscle cells (MUSCLE, SMOOTH, VASCULAR), PHAGOCYTES and the mesangial EXTRACELLULAR MATRIX." [] is_a: UBERON:0003567 ! abdomen connective tissue is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0002319 ! mesangium relationship: part_of UBERON:0004190 ! renal glomerulus vasculature [Term] id: UBERON:0002321 name: extraglomerular mesangium is_a: UBERON:0003567 ! abdomen connective tissue is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001229 ! renal corpuscle relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus relationship: part_of UBERON:0002319 ! mesangium [Term] id: UBERON:0002323 name: coelemic cavity lumen def: "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." [] synonym: "body cavity" RELATED [] synonym: "celom" RELATED [] synonym: "coelom" RELATED [] synonym: "coelome" RELATED [] synonym: "coelomic cavity" EXACT [] synonym: "coelomic cavity lumen" EXACT [] synonym: "hemocoel" RELATED [] synonym: "space of body compartment" EXACT [] synonym: "ventral body cavity" NARROW [] is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0004458 ! body cavity or lining relationship: develops_from UBERON:0003886 ! body cavity precursor [Term] id: UBERON:0002324 name: muscle of back def: "A muscle organ that is part of a back [Automatically generated definition]." [] synonym: "back muscle" EXACT [] synonym: "back muscle organ" EXACT [] synonym: "muscle organ of back" EXACT [] is_a: UBERON:0001774 ! muscle of trunk is_a: UBERON:0005174 ! dorsal region organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0004469 ! musculature of back [Term] id: UBERON:0002325 name: epithelium of urethra def: "The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes.." [] synonym: "epithelial tissue of urethra" EXACT [] synonym: "urethra epithelial tissue" EXACT [] synonym: "urethra epithelium" EXACT [] synonym: "urethral epithelium" RELATED [] synonym: "urethral plate" RELATED [] synonym: "urethral seam" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0006555 ! excretory tube is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: UBERON:0002326 name: lamina propria of urethra def: "A lamina propria that is part of a urethra [Automatically generated definition]." [] synonym: "lamina propria mucosa of urethra" EXACT [] synonym: "lamina propria mucosae of urethra" EXACT [] synonym: "urethra lamina propria" EXACT [] synonym: "urethra lamina propria mucosa" EXACT [] synonym: "urethra lamina propria mucosae" EXACT [] synonym: "urethral lamina propria" RELATED [] is_a: UBERON:0000030 ! lamina propria is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0002328 name: notochord def: "a flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." [] synonym: "embryonic notocord" EXACT [] synonym: "notochorda" RELATED [] synonym: "notocord" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0004880 ! chordamesoderm relationship: develops_from UBERON:0006267 ! notochordal plate relationship: part_of UBERON:0011137 ! axial skeletal system [Term] id: UBERON:0002329 name: somite def: "Somites are spheres of epithelial cells that form sequentially along the anteriorposterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." [] synonym: "epithelial somite" RELATED [] synonym: "mesodermal cluster" EXACT [] synonym: "somites" RELATED [] synonym: "somitic mesoderm" RELATED [] synonym: "somitus" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007503 ! epithelial vesicle is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0003059 ! presomitic mesoderm [Term] id: UBERON:0002330 name: exocrine system def: "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." [] synonym: "exocrine glandular system" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0002331 name: umbilical cord def: "The connecting cord from the developing embryo to the placenta." [] synonym: "birth cord" RELATED [] synonym: "chorda umbilicalis" EXACT [] synonym: "connecting stalk" RELATED [] synonym: "funiculus umbilicalis" EXACT [] synonym: "funiculus umbilicalis" RELATED [] synonym: "yolk stalk" RELATED [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0007806 ! connecting stalk [Term] id: UBERON:0002335 name: macula densa def: "The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus[GO]." [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus [Term] id: UBERON:0002338 name: lamina propria of bronchus def: "A lamina propria that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi lamina propria" EXACT [] synonym: "bronchi lamina propria mucosa" EXACT [] synonym: "bronchi lamina propria mucosae" EXACT [] synonym: "bronchial trunk lamina propria" EXACT [] synonym: "bronchial trunk lamina propria mucosa" EXACT [] synonym: "bronchial trunk lamina propria mucosae" EXACT [] synonym: "bronchus lamina propria" EXACT [] synonym: "bronchus lamina propria mucosa" EXACT [] synonym: "bronchus lamina propria mucosae" EXACT [] synonym: "lamina propria mucosa of bronchi" EXACT [] synonym: "lamina propria mucosa of bronchial trunk" EXACT [] synonym: "lamina propria mucosa of bronchus" EXACT [] synonym: "lamina propria mucosae of bronchi" EXACT [] synonym: "lamina propria mucosae of bronchial trunk" EXACT [] synonym: "lamina propria mucosae of bronchus" EXACT [] synonym: "lamina propria of bronchi" EXACT [] synonym: "lamina propria of bronchial trunk" EXACT [] is_a: UBERON:0000031 ! lamina propria of trachea is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0000410 ! bronchial mucosa relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0002342 name: neural crest def: "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." [] synonym: "crista neuralis" RELATED [] synonym: "neural crest material" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010316 ! germ layer / neural crest relationship: develops_from UBERON:0003075 ! neural plate relationship: develops_from UBERON:0005062 ! neural fold relationship: part_of UBERON:0002346 ! neurectoderm [Term] id: UBERON:0002343 name: abdomen musculature def: "Set of all muscles in abdomen." [] synonym: "abdominal musculature" EXACT [] synonym: "muscle group of abdomen" EXACT [] synonym: "muscles of abdomen" EXACT [] synonym: "musculature of abdomen" EXACT [] synonym: "musculature of abdominal wall" EXACT [] synonym: "set of muscles of abdomen" EXACT [] is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0002346 name: neurectoderm def: "Embryonic ectoderm that gives rise to nervous tissue." [] synonym: "epithelium tubi neuralis; neuroectoderma" RELATED [] synonym: "neuaral ectoderm" RELATED [] synonym: "neural ectoderm" EXACT [] synonym: "neuroectoderm" EXACT [] synonym: "presumptive central nervous system" RELATED [] synonym: "ventral neurogenic region" RELATED [] is_a: UBERON:0000923 ! germ layer is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0000924 ! ectoderm [Term] id: UBERON:0002348 name: epicardium def: "Region of visceral serous pericardium which has as its part, the mesothelium, subepicardial layer of epicardium and the fibroelastic connective tissue that is attached to the myocardium and is continuous with the parietal serous pericardium[FMA]. External layer of the heart[ZFA]." [] synonym: "heart epicardium" EXACT [] synonym: "lamina visceralis pericardii serosi" RELATED [] synonym: "visceral serous pericardium of heart" EXACT [] synonym: "visceral serous pericardium proper" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0004160 ! proepicardium relationship: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0002425 ! visceral serous pericardium [Term] id: UBERON:0002349 name: myocardium def: "middle muscular layer of the heart wall[M-W]. Muscle layer of organ which has as its parts the myocardium proper and the conducting system of the heart[FMA]." [] synonym: "cardiac muscle" RELATED [] synonym: "heart muscle" RELATED [] synonym: "heart muscle " RELATED [] synonym: "heart myocardium" EXACT [] synonym: "muscle of heart" EXACT [] is_a: UBERON:0005983 ! heart layer relationship: part_of UBERON:0000383 ! musculature of body relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0002350 name: conducting system of heart def: "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]" [] synonym: "cardiac conducting system" EXACT [] synonym: "cardiac conduction system" EXACT [] synonym: "cardiac impulse conducting system" EXACT [] synonym: "cardionector" EXACT [] synonym: "central conduction system" RELATED [] synonym: "heart conduction system" EXACT [] synonym: "impulse conducting system" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart relationship: part_of UBERON:0002349 ! myocardium [Term] id: UBERON:0002351 name: sinoatrial node def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." [] synonym: "cardiac pacemaker" EXACT [] synonym: "Koch's node" EXACT [] synonym: "node of Keith-Flack" EXACT [] synonym: "nodus sinuatrialis" EXACT [] synonym: "nodus sinuatrialis" RELATED [] synonym: "SA nodal muscle tissue" EXACT [] synonym: "SA node" EXACT [] synonym: "sinoatrial node" EXACT [] synonym: "sinu-atrial node" EXACT [] synonym: "sinuatrial nodal muscle tissue" EXACT [] synonym: "sinuatrial node" EXACT [] synonym: "sinus node" EXACT [] synonym: "sinus node of Keith and Flack" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium relationship: part_of UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0002352 name: atrioventricular node def: "Subdivision of conducting system of heart which is located in the muscular part of the interatrial septum that is continuous with the atrioventricular bundle.[FMA]" [] synonym: "aschoff-tawara node" EXACT [] synonym: "atrioventricular nodal muscle tissue" EXACT [] synonym: "atriovetricular node" RELATED [] synonym: "AV nodal muscle tissue" EXACT [] synonym: "AV node" EXACT [] synonym: "node of Tawara" EXACT [] synonym: "nodus atrioventricularis" RELATED [] is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium relationship: part_of UBERON:0002085 ! interatrial septum relationship: part_of UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0002353 name: atrioventricular bundle def: "A part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers[GO]" [] synonym: "atrioventricular bundle muscle tissue" EXACT [] synonym: "atrioventricular fasciculus" EXACT [] synonym: "AV bundle" EXACT [] synonym: "bundle of His" EXACT [] synonym: "fasciculus atrioventricularis" EXACT [] synonym: "His bundle" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium relationship: part_of UBERON:0002350 ! conducting system of heart relationship: part_of UBERON:0004146 ! His-Purkinje system [Term] id: UBERON:0002355 name: pelvis def: "Subdivision of abdomen, which is demarcated from the abdomen proper by the plane of the superior pelvic aperture, and from the perineum by the inferior surface of the pelvic diaphragm; together with the abdomen proper, it constitutes the abdomen[FMA]." [] synonym: "lesser pelvis" EXACT [] synonym: "pelvic region" EXACT [] synonym: "pelvis region" EXACT [] synonym: "true pelvis" EXACT [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0002357 name: serous pericardium def: "Serous membrane which has as its parts the epicardium and parietal serous pericardium that surrounds pericardial cavity." [] synonym: "pericardium serosum" RELATED [] synonym: "serous portion of pericardium" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005983 ! heart layer relationship: part_of UBERON:0002406 ! pericardial sac [Term] id: UBERON:0002358 name: peritoneum def: "A serous membrane that lines the peritoneal cavity[VHOG,modified]." [] synonym: "peritonaeum" RELATED [] is_a: UBERON:0000042 ! serous membrane relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0003697 ! abdominal wall [Term] id: UBERON:0002360 name: meninx def: "Membrane organ that surrounds the brain and the spinal cord." [] synonym: "layer of meninges" EXACT [] synonym: "meningeal layer" EXACT [] synonym: "meninx primitiva" NARROW [] is_a: UBERON:0000094 ! membrane organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0010743 ! meningeal cluster [Term] id: UBERON:0002363 name: dura mater def: "Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections." [] synonym: "dura" RELATED [] synonym: "dura mater of neuraxis" EXACT [] synonym: "pachymeninges" EXACT [] is_a: UBERON:0002360 ! meninx is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0007647 ! ectomeninx [Term] id: UBERON:0002364 name: tympanic membrane def: "A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted]." [] synonym: "ear drum" EXACT [] synonym: "eardrum" EXACT [] synonym: "lateral wall of tympanic cavity" EXACT [] synonym: "membranous wall of tympanic cavity" EXACT [] synonym: "myrinx" EXACT [] synonym: "paries membranaceus cavi tympani" EXACT [] synonym: "Rivinus' membrane" EXACT [] synonym: "tympanum" RELATED [] is_a: UBERON:0000094 ! membrane organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0009213 ! pharyngeal membrane of 1st arch relationship: part_of UBERON:0001756 ! middle ear [Term] id: UBERON:0002365 name: exocrine gland def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [] synonym: "ducted gland" EXACT [] synonym: "glandula exocrina" EXACT [] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002330 ! exocrine system relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0002367 name: prostate gland def: "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [] synonym: "male prostate" EXACT [] synonym: "prostata" RELATED [] synonym: "prostate" EXACT [] is_a: UBERON:0010147 ! male accessory sex gland relationship: develops_from UBERON:0003820 ! prostate bud [Term] id: UBERON:0002368 name: endocrine gland def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." [] synonym: "ductless gland" EXACT [] synonym: "ductless gland" RELATED [] synonym: "glandula endocrina" EXACT [] synonym: "glandulae endocrinae" RELATED [] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000949 ! endocrine system relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0002369 name: adrenal gland def: "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." [] synonym: "adrenal" RELATED [] synonym: "adrenal capsule" RELATED [] synonym: "adrenal medulla cell" RELATED [] synonym: "atrabiliary capsule" RELATED [] synonym: "epinephric gland" RELATED [] synonym: "epinephros" RELATED [] synonym: "glandula adrenalis" EXACT [] synonym: "glandula suprarenalis" EXACT [] synonym: "glandula suprarenalis" RELATED [] synonym: "interrenal gland" RELATED [] synonym: "suprarenal capsule" RELATED [] synonym: "suprarenal gland" RELATED [] is_a: UBERON:0006858 ! adrenal/interrenal gland relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0002370 name: thymus def: "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." [] synonym: "thymus gland" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0005058 ! hemolymphoid system gland relationship: develops_from UBERON:0005562 ! thymus primordium relationship: part_of UBERON:0000949 ! endocrine system relationship: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0002405 ! immune system relationship: part_of UBERON:0009113 ! thymic region [Term] id: UBERON:0002371 name: bone marrow def: "flexible tissue found in the hollow interior of bones. In adults, marrow in large bones produces new blood cells[WP]." [] synonym: "medulla of bone" RELATED [] synonym: "medulla ossea" EXACT [] synonym: "medulla ossium" EXACT [] is_a: UBERON:0012429 ! hemopoietic tissue relationship: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0002405 ! immune system [Term] id: UBERON:0002372 name: tonsil def: "Portion of lymphoid tissue on either side of the throat." [] synonym: "Mandel" RELATED [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0001735 ! tonsillar ring [Term] id: UBERON:0002376 name: muscle of head def: "Any muscle that is part of a head[Automatically generated definition]." [] synonym: "adult head muscle organ" EXACT [] synonym: "cephalic muscle" EXACT [] synonym: "cephalic musculature" EXACT [] synonym: "cranial muscle " RELATED [] synonym: "head muscle" EXACT [] synonym: "head muscle organ" EXACT [] synonym: "head muscles" RELATED [] synonym: "muscle organ of adult head" EXACT [] synonym: "muscle organ of head" EXACT [] synonym: "musculus caput" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000033 ! head relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0004461 ! musculature of head [Term] id: UBERON:0002377 name: muscle of neck def: "Muscle organ which is a part of the neck. Examples: platysma, sternocleidomastoid, cricothyroid muscle.[FMA]" [] synonym: "muscle organ of neck" EXACT [] synonym: "muscle organ of neck (volume)" EXACT [] synonym: "neck (volume) muscle organ" EXACT [] synonym: "neck muscle" EXACT [] synonym: "neck muscle organ" EXACT [] is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0004465 ! musculature of neck [Term] id: UBERON:0002378 name: muscle of abdomen def: "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." [] synonym: "abdomen muscle" EXACT [] synonym: "abdomen muscle organ" EXACT [] synonym: "abdominal muscle" EXACT [] synonym: "abdominal wall muscle" EXACT [] synonym: "muscle organ of abdomen" EXACT [] is_a: UBERON:0003833 ! abdominal segment muscle is_a: UBERON:0005172 ! abdomen organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0002343 ! abdomen musculature relationship: part_of UBERON:0003697 ! abdominal wall [Term] id: UBERON:0002384 name: connective tissue def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." [] synonym: "Bindegewebe" RELATED [] synonym: "portion of connective tissue" EXACT [] synonym: "textus connectivus" EXACT [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0002385 name: muscle tissue def: "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." [] synonym: "muscular tissue" EXACT [] synonym: "portion of muscle tissue" EXACT [] synonym: "textus muscularis" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0001015 ! musculature [Term] id: UBERON:0002390 name: hematopoietic system def: "Anatomical system that is involved in the production of hematopoietic cells. In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes." [] synonym: "Blutbildungssystem" RELATED [] synonym: "haematological system" EXACT [] synonym: "haematopoietic system" RELATED [] synonym: "haemopoietic system" EXACT [] synonym: "hematological system" RELATED [] synonym: "hematolymphoid system" RELATED [] synonym: "hemopoietic system" RELATED [] synonym: "organa haemopoietica" EXACT [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0003061 ! blood island relationship: part_of UBERON:0002193 ! hemolymphoid system [Term] id: UBERON:0002392 name: nasolacrimal duct def: "The nasolacrimal duct (sometimes called tear duct) carries tears from the lacrimal sac into the nasal cavity. Excess tears flow through nasolacrimal duct which opens in the nose. This is the reason the nose starts to run when a person is crying or has watery eyes from an allergy, and why one can sometimes taste eye drops. Like the lacrimal sac, the duct is lined by stratified columnar epithelium containing mucus-secreting goblet cells, and is surrounded by connective tissue. Obstruction of the nasolacrimal duct leads to the excess overflow of tears called epiphora. A congenital obstruction can cause cystic expansion of the duct and is called a dacrocystocele or Timo cyst. Persons with dry eye conditions can be fitted with punctal plugs that seal the ducts to limit the amount of fluid drainage and retain moisture. The canal containing the nasolacrimal duct is called the nasolacrimal canal. [WP,unvetted]." [] synonym: "d. nasolacrimalis" RELATED [] synonym: "nasolacrimal duct - posterior naris" BROAD [] is_a: UBERON:0000058 ! duct is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0006266 ! nasolacrimal groove relationship: part_of UBERON:0001850 ! lacrimal duct [Term] id: UBERON:0002394 name: bile duct def: "Duct that carries bile from the liver to the small intestine." [] synonym: "biliary duct" RELATED [] synonym: "gall duct" RELATED [] synonym: "hepatic duct" RELATED [] is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0008835 ! hepatic diverticulum relationship: part_of UBERON:0001173 ! biliary tree relationship: part_of UBERON:0002294 ! biliary system [Term] id: UBERON:0002400 name: parietal pleura def: "Parietal serous membrane which is continuous with the visceral pleura and is attached to the dome of the diaphragm.[FMA]" [] synonym: "pleura parietalis" RELATED [] is_a: UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura [Term] id: UBERON:0002401 name: visceral pleura def: "Visceral serous membrane which is continuous with the parietal pleura and is attached to the parenchyma of lobe of lung.[FMA]" [] synonym: "lung mesothelium" RELATED [] synonym: "lung pleura" RELATED [] synonym: "pleura pulmonalis" EXACT [] synonym: "pleura visceralis" EXACT [] synonym: "pleura visceralis (pulmonalis)" EXACT [] synonym: "pulmonary pleura" EXACT [] is_a: UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0002402 name: pleural cavity def: "Cavity of serous sac surropunded by the pleura.[FMA]" [] synonym: "cavitas pleurallis" RELATED [] is_a: UBERON:0002323 ! coelemic cavity lumen intersection_of: UBERON:0002323 ! coelemic cavity lumen intersection_of: part_of UBERON:0009778 ! pleural sac relationship: develops_from UBERON:0003887 ! intraembryonic coelom relationship: part_of UBERON:0009778 ! pleural sac [Term] id: UBERON:0002405 name: immune system def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0002406 name: pericardial sac def: "Serous sac, which has as parts the serous pericardium and the pericardial cavity [FMA]." [] synonym: "pericardium" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005906 ! serous sac relationship: part_of UBERON:0001009 ! circulatory system relationship: part_of UBERON:0002407 ! pericardium [Term] id: UBERON:0002407 name: pericardium def: "The outer membrane/wall of the developing heart, surrounding the myocardium. " [] is_a: UBERON:0004457 ! cavity lining is_a: UBERON:0005983 ! heart layer is_a: UBERON:0006914 ! squamous epithelium is_a: UBERON:0012275 ! meso-epithelium relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0002410 name: autonomic nervous system def: "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [] synonym: "ANS" RELATED [] synonym: "divisio autonomica systematis nervosi peripherici" RELATED [] synonym: "visceral nervous system" EXACT [] is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0002412 name: vertebra def: "Irregular bone that articulates with other vertebrae, or with one other vertebra and the skull or the sacrum[FMA]. All serially repeated ossified, cartilaginous, and ligamentous elements around the notochord (Schultze and Arratia, 1988)[ZFA]." [] synonym: "vertebra bone" EXACT [] synonym: "vertebrae" EXACT [] is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0008001 ! irregular bone is_a: UBERON:0010913 ! vertebral element is_a: UBERON:0015005 ! vertebra endochondral element relationship: develops_from UBERON:0011094 ! vertebra cartilage element relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0002416 name: integumental system def: "organ system that protects the body from damage, comprising the skin and its adnexa (including hair, scales, and nails). The integumentary system has a variety of functions; it may serve to waterproof, cushion and protect the deeper tissues, excrete wastes, regulate temperature and is the location of receptors for pain, sensation, pressure and temperature. In humans the integumentary system additionally provides vitamin D synthesis[WP]." [] synonym: "dermal system" RELATED [] synonym: "integumentary system" EXACT [] synonym: "integumentum commune" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0002417 name: abdominal segment of trunk def: "the abdominal segment of the torso." [] synonym: "abdomen/pelvis/perineum" RELATED [] synonym: "lower body" RELATED [] synonym: "lumbar region" RELATED [] is_a: UBERON:0009569 ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis [Term] id: UBERON:0002418 name: cartilage tissue def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." [] synonym: "cartilage" RELATED [] synonym: "cartilage tissue" EXACT [] synonym: "cartilages" RELATED [] synonym: "cartilaginous tissue" EXACT [] synonym: "chondrogenic tissue" EXACT [] is_a: UBERON:0004755 ! skeletal tissue relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] id: UBERON:0002419 name: skin gland def: "A gland that is part of a skin of body [Automatically generated definition]." [] synonym: "glandulae cutis" EXACT [] synonym: "set of skin glands" RELATED [] synonym: "skin glands" RELATED [] synonym: "skin glands set" RELATED [] is_a: UBERON:0003297 ! gland of integumental system is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006003 ! integumentary adnexa intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body [Term] id: UBERON:0002420 name: basal ganglion def: "An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified]." [] synonym: "basal ganglia" RELATED [] synonym: "basal ganglion of telencephalon" EXACT [] synonym: "basal nucleus" RELATED [] synonym: "nuclei basales" RELATED [] is_a: UBERON:0003528 ! brain grey matter is_a: UBERON:0007245 ! nuclear complex of neuraxis relationship: part_of UBERON:0010011 ! collection of basal ganglia [Term] id: UBERON:0002421 name: hippocampal formation def: "Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment]." [] synonym: "archipallium" RELATED [] synonym: "formatio hippocampi" RELATED [] synonym: "hippocampus" NARROW [] synonym: "hippocampus (crosby)" EXACT [] synonym: "major hippocampus" RELATED [] synonym: "primal cortex" RELATED [] synonym: "seahorse" RELATED [] is_a: UBERON:0002791 ! regional part of telencephalon relationship: part_of UBERON:0000203 ! pallium [Term] id: UBERON:0002422 name: fourth ventricle def: "Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures." [] synonym: "4th ventricle" RELATED [] synonym: "fourth ventricle proper" RELATED [] synonym: "hindbrain ventricle" RELATED [] synonym: "IVth ventricle" RELATED [] synonym: "rhombencephalic ventricle" RELATED [] synonym: "rhombencephalic vesicle" NARROW [] synonym: "ventricle IV" EXACT [] synonym: "ventricle of hindbrain" RELATED [] synonym: "ventricle of rhombencephalon" RELATED [] synonym: "ventriculus quartus" RELATED [] synonym: "visual area V4" RELATED [] is_a: UBERON:0004086 ! brain ventricle intersection_of: UBERON:0004086 ! brain ventricle intersection_of: part_of UBERON:0002028 ! hindbrain relationship: develops_from UBERON:0013149 ! hindbrain vesicle relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0002423 name: hepatobiliary system def: "The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. The parts are: liver, bile duct, gall bladder and hepatic duct" [] synonym: "hepaticobiliary system" EXACT [] synonym: "liver and biliary system" EXACT [] synonym: "liver/biliary system" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0002424 name: oral epithelium def: "Epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues" [] synonym: "epithelium of mucosa of mouth" EXACT [] synonym: "epithelium of oral mucosa" EXACT [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0003729 ! mouth mucosa [Term] id: UBERON:0002425 name: visceral serous pericardium def: "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." [] synonym: "epicardium" RELATED [] synonym: "lamina visceralis pericardii serosi" RELATED [] synonym: "serous visceral pericardium" EXACT [] synonym: "visceral lamina of serous pericardium" EXACT [] synonym: "visceral layer of serous pericardium" EXACT [] synonym: "visceral pericardium" EXACT [] is_a: UBERON:0002357 ! serous pericardium [Term] id: UBERON:0002426 name: chest muscle def: "A muscle organ that is part of a chest [Automatically generated definition]." [] synonym: "anterior thoracic region muscle organ" EXACT [] synonym: "anterolateral part of thorax muscle organ" EXACT [] synonym: "chest muscle organ" EXACT [] synonym: "front of thorax muscle organ" EXACT [] synonym: "muscle of thorax" EXACT [] synonym: "muscle organ of anterior thoracic region" EXACT [] synonym: "muscle organ of anterolateral part of thorax" EXACT [] synonym: "muscle organ of chest" EXACT [] synonym: "muscle organ of front of thorax" EXACT [] synonym: "musculus thoracicus" EXACT [] synonym: "thoracic muscle" EXACT [] is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0005175 ! chest organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0004472 ! musculature of chest [Term] id: UBERON:0002429 name: cervical lymph node def: "Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted]." [] synonym: "lymph node of neck" EXACT [] is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0002435 name: striatum def: "A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO]." [] synonym: "caudate putamen" RELATED [] synonym: "corpus striatum" RELATED [] synonym: "corpus striatum (Zilles)" RELATED [] synonym: "dorsal striatum" RELATED [] synonym: "neostriatum" EXACT [] synonym: "neuraxis striatum" EXACT [] synonym: "striate nucleus" EXACT [] synonym: "striated nucleus" RELATED [] synonym: "striatum" EXACT [] synonym: "striatum of neuraxis" EXACT [] is_a: UBERON:0011300 ! gray matter of telencephalon relationship: part_of UBERON:0000204 ! ventral part of telencephalon relationship: part_of UBERON:0000369 ! corpus striatum relationship: part_of UBERON:0002420 ! basal ganglion relationship: part_of UBERON:0006098 ! basal nuclear complex [Term] id: UBERON:0002443 name: choroidal blood vessel def: "A blood vessel that is part of a choroid [Automatically generated definition]." [] synonym: "blood vessel of choroid" EXACT [] synonym: "blood vessel of choroid coat" EXACT [] synonym: "blood vessel of choroidea" EXACT [] synonym: "blood vessel of posterior uvea" EXACT [] synonym: "choroid blood vessel" EXACT [] synonym: "choroid blood vessels" EXACT [] synonym: "choroid blood vessels set" EXACT [] synonym: "choroid coat blood vessel" EXACT [] synonym: "choroidea blood vessel" EXACT [] synonym: "posterior uvea blood vessel" EXACT [] synonym: "set of choroid blood vessels" RELATED [] synonym: "vasa sanguinea choroideae" EXACT [] is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001776 ! optic choroid relationship: part_of UBERON:0001776 ! optic choroid [Term] id: UBERON:0002450 name: decidua def: "Uterine lining (endometrium) during a pregnancy, which forms the maternal part of the placenta. It is formed under the influence of progesterone and forms highly-characteristic cells." [] synonym: "decidous membrane" EXACT [] synonym: "decidua basalis" RELATED [] synonym: "endometrium" RELATED [] synonym: "maternal decidual layer" RELATED [] synonym: "placenta maternal decidual layer" RELATED [] synonym: "uterine decidua" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure relationship: develops_from UBERON:0000459 ! uterine wall relationship: part_of UBERON:0001987 ! placenta [Term] id: UBERON:0002456 name: internal thoracic artery def: "In human anatomy, the internal thoracic artery (ITA), previously known as the internal mammary artery (a name still common among surgeons), is an artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted]." [] synonym: "arteria mammaria interna" RELATED [] synonym: "arteria thoracica interna" RELATED [] synonym: "internal mammary artery" EXACT [] synonym: "internal thoracic mammary artery" EXACT [] is_a: UBERON:0004573 ! systemic artery relationship: part_of UBERON:0001533 ! subclavian artery [Term] id: UBERON:0002457 name: intersomitic artery def: "the small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries" [] synonym: "intersegmental artery" EXACT [] is_a: UBERON:0001637 ! artery is_a: UBERON:0014907 ! intersomitic vessel [Term] id: UBERON:0002465 name: lymphoid system def: "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system (Wikipedia)." [] synonym: "lymphatic circulatory system" RELATED [] synonym: "lymphatic system" NARROW [] synonym: "systema lymphoideum" RELATED [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0002193 ! hemolymphoid system relationship: part_of UBERON:0002405 ! immune system [Term] id: UBERON:0002469 name: esophagus mucosa def: "A mucosa that is part of a esophagus [Automatically generated definition]." [] synonym: "esophageal mucosa" EXACT [] synonym: "esophagus mucosa" EXACT [] synonym: "esophagus mucosa of organ" EXACT [] synonym: "esophagus mucous membrane" EXACT [] synonym: "esophagus organ mucosa" EXACT [] synonym: "gullet mucosa" EXACT [] synonym: "gullet mucosa of organ" EXACT [] synonym: "gullet mucous membrane" EXACT [] synonym: "gullet organ mucosa" EXACT [] synonym: "lamina muscularis mucosae oesophageae" EXACT [] synonym: "mucosa of esophagus" EXACT [] synonym: "mucosa of gullet" EXACT [] synonym: "mucosa of oesophagus" EXACT [] synonym: "mucosa of organ of esophagus" EXACT [] synonym: "mucosa of organ of gullet" EXACT [] synonym: "mucosa of organ of oesophagus" EXACT [] synonym: "mucous membrane of esophagus" EXACT [] synonym: "mucous membrane of gullet" EXACT [] synonym: "mucous membrane of oesophagus" EXACT [] synonym: "muscularis mucosae of oesophagus" RELATED [] synonym: "oesophageal mucosa" EXACT [] synonym: "oesophagus mucosa" EXACT [] synonym: "oesophagus mucosa of organ" EXACT [] synonym: "oesophagus mucous membrane" EXACT [] synonym: "oesophagus organ mucosa" EXACT [] synonym: "organ mucosa of esophagus" EXACT [] synonym: "organ mucosa of gullet" EXACT [] synonym: "organ mucosa of oesophagus" EXACT [] synonym: "tunica mucosa esophagi" EXACT [] synonym: "tunica mucosa oesophageae" EXACT [] synonym: "tunica mucosa oesophagi" EXACT [] synonym: "tunica mucosa oesophagi" RELATED [] is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0002481 name: bone tissue def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." [] synonym: "bone" RELATED [] synonym: "calcium tissue" EXACT [] synonym: "osseous tissue" EXACT [] synonym: "osteogenic tissue" EXACT [] is_a: UBERON:0004755 ! skeletal tissue relationship: part_of UBERON:0001474 ! bone element [Term] id: UBERON:0002485 name: prostate duct def: "the minute canals that pass the prostatic secretions to the urethra." [] synonym: "duct of prostate" EXACT [] synonym: "duct of prostate gland" EXACT [] synonym: "prostate duct" EXACT [] synonym: "prostate gland duct" EXACT [] synonym: "prostatic duct" EXACT [] is_a: UBERON:0005904 ! duct of male reproductive system intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0002367 ! prostate gland relationship: develops_from UBERON:0003820 ! prostate bud relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0002493 name: uterine artery def: "The uterine artery is an artery in females that supplies blood to the uterus. [WP,unvetted]." [] synonym: "arteria uterina" RELATED [] is_a: UBERON:0001637 ! artery is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus [Term] id: UBERON:0002495 name: long bone def: "Long bone is a limb bone that is subcylindrical and has a shaft with periosteum separating the ends of the bones. Long bones are present only in the limbs[VSAO:wd]." [] synonym: "os longum" RELATED [] is_a: UBERON:0001474 ! bone element relationship: part_of UBERON:0002091 ! appendicular skeleton [Term] id: UBERON:0002499 name: cochlear labyrinth def: "The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001849 ! membranous labyrinth [Term] id: UBERON:0002506 name: iris epithelium def: "An epithelium that is part of a iris [Automatically generated definition]." [] synonym: "epithelial tissue of iris" EXACT [] synonym: "epithelium of iris" EXACT [] synonym: "epithelium pigmentosum (iris)" EXACT [] synonym: "epithelium pigmentosum iridis" EXACT [] synonym: "iris epithelial tissue" EXACT [] synonym: "iris epithelium" EXACT [] synonym: "iris pigmented epithelium" RELATED [] synonym: "pigmented epithelium of iris" EXACT [] is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0002507 name: abdominal lymph node def: "A lymph node that is part of an abdomen [Automatically generated definition]." [] synonym: "abdomen lymph node" EXACT [] synonym: "lymph node of abdomen" EXACT [] is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0002509 name: mesenteric lymph node def: "the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." [] synonym: "mesenteric node" EXACT [] synonym: "nodi lymphoidei mesenterici" RELATED [] is_a: UBERON:0002507 ! abdominal lymph node is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002507 ! abdominal lymph node intersection_of: part_of UBERON:0002095 ! mesentery relationship: part_of UBERON:0002095 ! mesentery [Term] id: UBERON:0002512 name: corpus luteum def: "a transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID]." [] synonym: "corpora lutea" EXACT [] synonym: "corpus luteum of ovary" EXACT [] synonym: "luteal gland" RELATED [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0005398 ! female reproductive gland relationship: develops_from UBERON:0001305 ! ovarian follicle relationship: part_of UBERON:0000949 ! endocrine system relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0002513 name: endochondral bone def: "Replacement bone that forms within cartilage." [] synonym: "cartilaginous bone" RELATED [] synonym: "ossified chondrogenic bone" EXACT [] is_a: UBERON:0001474 ! bone element is_a: UBERON:0010363 ! endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: develops_from UBERON:0005863 ! cartilaginous condensation relationship: develops_from UBERON:0005863 ! cartilaginous condensation relationship: develops_from UBERON:0007844 ! cartilage element [Term] id: UBERON:0002517 name: basicranium def: "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." [] synonym: "base of skull" EXACT [] synonym: "basis cranii" EXACT [] synonym: "basis cranii" RELATED [] synonym: "cranial base" RELATED [] synonym: "skull base" EXACT [] is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001703 ! neurocranium relationship: part_of UBERON:0002241 ! chondrocranium [Term] id: UBERON:0002518 name: otolith organ def: "saccule or utricle." [] synonym: "otolith organs" RELATED [] synonym: "saccule and utricle" RELATED [] synonym: "utricle and saccule" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003051 ! ear vesicle relationship: part_of UBERON:0001862 ! vestibular labyrinth [Term] id: UBERON:0002521 name: elastic tissue def: "Connective tissue composed of elastic fibers." [] synonym: "elastic connective tissue" EXACT [] synonym: "elastic fiber" NARROW [] synonym: "textus connectivus elasticus" EXACT [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0002523 name: tunica intima def: "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." [] synonym: "Bichat's tunic" RELATED [] synonym: "intima" RELATED [] synonym: "tunica intima vasorum" RELATED [] is_a: UBERON:0004797 ! blood vessel layer [Term] id: UBERON:0002527 name: pancreatic lymph node def: "A lymph node that is part of a pancreas [Automatically generated definition]." [] synonym: "lymph node of pancreas" EXACT [] synonym: "pancreas lymph node" EXACT [] synonym: "pancreatic node" EXACT [] synonym: "pyloric lymph node" RELATED [] is_a: UBERON:0002507 ! abdominal lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas [Term] id: UBERON:0002530 name: gland def: "A gland is an organ in an animal's body that synthesizes a substance for release such as hormones or breast milk, often into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland). A gland is an organ specialised for secretion[GO]." [] synonym: "Druese" RELATED [] synonym: "glandula" RELATED [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0002532 name: epiblast (generic) def: "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]" [] synonym: "blastocyst" RELATED [] synonym: "ectoblast" RELATED [] synonym: "epiblast" EXACT [] synonym: "epiblastus" RELATED [] synonym: "primitive ectoderm" RELATED [] is_a: UBERON:0002050 ! embryonic structure [Term] id: UBERON:0002539 name: pharyngeal arch def: "One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches" [] synonym: "arcus pharyngei" RELATED [] synonym: "branchial arch" NARROW [] synonym: "pharyngeal arches" EXACT [] synonym: "visceral arch" RELATED [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0010188 ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0008814 ! pharyngeal system relationship: part_of UBERON:0008816 ! embryonic head [Term] id: UBERON:0002540 name: lateral line system def: "a line of neuroblasts along the sides of fish and amphibia that detect vibrations and pressure changes." [] synonym: "lateral line organs" RELATED [] synonym: "lateral line stitches" RELATED [] synonym: "lateral-line organs" RELATED [] synonym: "ll" RELATED [] is_a: UBERON:0001032 ! sensory system relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0002546 name: cranial placode def: "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." [] synonym: "placode" BROAD [] is_a: UBERON:0005085 ! ectodermal placode relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0002553 name: anatomical cavity def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." [] synonym: "cavity" BROAD [] is_a: UBERON:0000464 ! anatomical space [Term] id: UBERON:0002559 name: medullary reticular formation def: "The reticular formation is a series of brain nuclei located in the medulla oblongata" [] synonym: "bulb reticular formation" EXACT [] synonym: "bulbar reticular formation" EXACT [] synonym: "formatio reticularis myelencephali" RELATED [] synonym: "medulla oblongata reticular formation" EXACT [] synonym: "medulla oblonmgata reticular formation" EXACT [] synonym: "medullary reticular nucleus" EXACT [] synonym: "metepencephalon reticular formation" EXACT [] synonym: "reticular formation" BROAD [] synonym: "reticular formation of bulb" EXACT [] synonym: "reticular formation of medulla" EXACT [] synonym: "reticular formation of medulla oblongata" EXACT [] synonym: "reticular formation of medulla oblonmgata" EXACT [] synonym: "reticular formation of metepencephalon" EXACT [] synonym: "rhombencephalic reticular formation" EXACT [] is_a: UBERON:0002275 ! reticular formation is_a: UBERON:0002678 ! regional part of medulla oblongata intersection_of: UBERON:0002275 ! reticular formation intersection_of: part_of UBERON:0001896 ! medulla oblongata relationship: part_of UBERON:0001896 ! medulla oblongata [Term] id: UBERON:0002579 name: regional part of medullary reticular formation def: "A regional part of brain that is part of a medullary reticular formation [Automatically generated definition]." [] synonym: "medullary reticular formation segment" EXACT [] synonym: "segment of medullary reticular formation" EXACT [] is_a: UBERON:0002678 ! regional part of medulla oblongata intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0002559 ! medullary reticular formation relationship: part_of UBERON:0002559 ! medullary reticular formation [Term] id: UBERON:0002600 name: limbic lobe def: "The limbic lobe (also known as the Cingulate) is a portion of the brain associated with functions such as olfaction and emotion. It contains parts of other lobes, including the frontal, parietal, and temporal. Its main components are the fornicate gyrus, the hippocampus, and the amygdala It is related to the term limbic system, but unlike that term, 'limbic lobe' is a part of the Terminologia Anatomica, and there is less disagreement over what is included in the 'limbic lobe' than there is over what is included in the 'limbic system'. [WP,unvetted]." [] synonym: "fornicate convolution" RELATED [] synonym: "fornicate gyrus" EXACT [] synonym: "fornicate lobe" RELATED [] synonym: "grande lobe limbique of broca" EXACT [] synonym: "gyrus fornicatus" RELATED [] synonym: "lateral lemniscus (complex)" RELATED [] synonym: "limbic lobe (carpenter)" EXACT [] synonym: "lobus limbicus" RELATED [] is_a: UBERON:0003022 ! lobe parts of cerebral cortex [Term] id: UBERON:0002616 name: regional part of brain def: "A multi-tissue structure that is part of a brain [Automatically generated definition]." [] synonym: "anatomical structure of brain" EXACT [] synonym: "biological structure of brain" EXACT [] synonym: "brain anatomical structure" EXACT [] synonym: "brain biological structure" EXACT [] synonym: "brain part" EXACT [] synonym: "neuraxis segment" EXACT [] synonym: "segment of brain" EXACT [] is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0002619 name: regional part of cerebral cortex def: "A regional part of brain that is part of a cerebral cortex [Automatically generated definition]." [] synonym: "central canal, spinal cord/medulla" RELATED [] synonym: "cerebral cortex part" EXACT [] synonym: "cerebral cortex region" RELATED [] synonym: "neocortex region" EXACT [] synonym: "region of cerebral cortex" EXACT [] synonym: "segment of cerebral cortex" NARROW [] is_a: UBERON:0002791 ! regional part of telencephalon intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: UBERON:0002635 name: regional part of midbrain tegmentum def: "A multi-tissue structure that is part of a midbrain tegmentum." [] synonym: "midbrain tegmentum segment" EXACT [] synonym: "segment of midbrain tegmentum" EXACT [] is_a: UBERON:0002950 ! regional part of midbrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001943 ! midbrain tegmentum relationship: part_of UBERON:0001943 ! midbrain tegmentum [Term] id: UBERON:0002639 name: midbrain reticular formation def: "A reticular formation that is part of a midbrain." [] synonym: "formatio reticularis mesencephali" RELATED [] synonym: "formatio reticularis tegmentalis" RELATED [] synonym: "formatio reticularis tegmenti mesencephali" RELATED [] synonym: "MBRF" BROAD [] synonym: "reticular formation of midbrain" EXACT [] synonym: "substantia reticularis mesencephali" RELATED [] synonym: "tegmental reticular formation" EXACT [] is_a: UBERON:0002275 ! reticular formation is_a: UBERON:0002635 ! regional part of midbrain tegmentum intersection_of: UBERON:0002275 ! reticular formation intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001943 ! midbrain tegmentum [Term] id: UBERON:0002678 name: regional part of medulla oblongata def: "A regional part of brain that is part of a medulla oblongata [Automatically generated definition]." [] synonym: "medullary oblongata segment" EXACT [] synonym: "segment of medulla oblongata" EXACT [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001896 ! medulla oblongata relationship: part_of UBERON:0001896 ! medulla oblongata [Term] id: UBERON:0002680 name: regional part of metencephalon def: "A regional part of brain that is part of a metencephalon [Automatically generated definition]." [] synonym: "metencephalon subdivision" EXACT [] synonym: "segment of metencephalon" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001895 ! metencephalon relationship: part_of UBERON:0001895 ! metencephalon [Term] id: UBERON:0002743 name: basal forebrain def: "The basal forebrain is a collection of structures located ventrally to the striatum. It is considered to be the major cholinergic output of the CNS. It includes a group of structures that lie near the bottom of the front of the brain, including the nucleus basalis, diagonal band of Broca, and medial septal nuclei. These structures are important in the production of acetylcholine, which is then distributed widely throughout the brain. Acetylcholine affects the ability of brain cells to transmit information to one another, and also encourages plasticity, or learning. Thus, damage to the basal forebrain can reduce the amount of acetylcholine in the brain and impair learning. This may be one reason why basal forebrain damage can result in memory impairments such as amnesia and confabulation. One common cause of basal forebrain damage is aneurysm of the anterior communicating artery. Research, conducted by investigators from Children's Hospital Boston and the University of Helsinki, ties together previous observations about sleep and finds that nitric oxide production in the basal forebrain is both necessary and sufficient to produce sleep. This structure is defined, in part, as the place where adenosine acts on A1 receptors of cholinergic neurons. This results in hyperpolarization of cholinergic neurons, which inhibits the release of acetylcholine. Acetylcholine is known to promote wakefulness in the basal forebrain. Inhibition of acetylcholine release in the basal forebrain by adenosine causes slow wave sleep. The basal forebrain and adjacent areas are a focus for sleep research. Stimulating the basal forebrain gives rise to EEG sychrony and sleep. [WP,unvetted]." [] synonym: "basal forebrain area" RELATED [] synonym: "pars basalis telencephali" RELATED [] is_a: UBERON:0002780 ! regional part of forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0002749 name: regional part of cerebellar cortex def: "A regional part of brain that is part of a cerebellar cortex [Automatically generated definition]." [] synonym: "cerebellar cortical segment" EXACT [] synonym: "segment of cerebellar cortex" EXACT [] is_a: UBERON:0002946 ! regional part of cerebellum is_a: UBERON:0003528 ! brain grey matter intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0002129 ! cerebellar cortex relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: UBERON:0002780 name: regional part of forebrain def: "A regional part of brain that is part of a forebrain [Automatically generated definition]." [] synonym: "forebrain segment" EXACT [] synonym: "segment of forebrain" EXACT [] is_a: UBERON:0002616 ! regional part of brain intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0002784 name: regional part of diencephalon def: "A regional part of brain that is part of a diencephalon [Automatically generated definition]." [] synonym: "diencephalon segment" EXACT [] is_a: UBERON:0002780 ! regional part of forebrain intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0002791 name: regional part of telencephalon def: "A regional part of brain that is part of a telencephalon [Automatically generated definition]." [] synonym: "segment of telencephalon" EXACT [] synonym: "telencephalon segment" EXACT [] is_a: UBERON:0002780 ! regional part of forebrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0002827 name: auditory ganglion synonym: "acoustic ganglion" RELATED [] synonym: "acoustic ganglion VIII" EXACT [] synonym: "acoustico-vestibular VIII ganglion" EXACT [] synonym: "auditory ganglion" EXACT [] synonym: "ganglion VIII" EXACT [] synonym: "gVIII" EXACT [] synonym: "nucleus nervi oculomotorii ventrolateralis" RELATED [] synonym: "nucleus nervi oculomotorii, pars ventralis" RELATED [] synonym: "SAG" BROAD [] synonym: "statoacoustic (VIII) ganglion" EXACT [] synonym: "statoacoustic ganglia" EXACT [] synonym: "statoacoustic VIII ganglion" RELATED [] synonym: "vestibulocochlear VIII ganglion" EXACT [] is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0003249 ! epithelium of otic placode relationship: develops_from UBERON:0005565 ! facio-acoustic neural crest relationship: develops_from UBERON:0012175 ! acoustico-facial VII-VIII ganglion complex relationship: part_of UBERON:0002105 ! vestibulo-auditory system [Term] id: UBERON:0002835 name: thoracic dorsal root ganglion def: "A dorsal root ganglion that is part of a thorax [Automatically generated definition]." [] synonym: "dorsal root ganglion of thorax" EXACT [] synonym: "ganglion of dorsal root of thorax" EXACT [] synonym: "ganglion spinalis of thorax" EXACT [] synonym: "thoracic dorsal root ganglion" EXACT [] synonym: "thoracic spinal ganglion" EXACT [] synonym: "thorax dorsal root ganglion" EXACT [] synonym: "thorax ganglion of dorsal root" EXACT [] synonym: "thorax ganglion spinalis" EXACT [] is_a: UBERON:0000044 ! dorsal root ganglion is_a: UBERON:0000961 ! thoracic ganglion intersection_of: UBERON:0000044 ! dorsal root ganglion intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0002926 name: gustatory epithelium is_a: UBERON:0006934 ! sensory epithelium intersection_of: UBERON:0006934 ! sensory epithelium intersection_of: part_of UBERON:0001033 ! gustatory system relationship: part_of UBERON:0000012 ! somatic nervous system relationship: part_of UBERON:0001033 ! gustatory system [Term] id: UBERON:0002946 name: regional part of cerebellum def: "A regional part of brain that is part of a cerebellum [Automatically generated definition]." [] synonym: "segment of cerebellum" EXACT [] is_a: UBERON:0002680 ! regional part of metencephalon intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: UBERON:0002950 name: regional part of midbrain def: "A regional part of brain that is part of a midbrain [Automatically generated definition]." [] synonym: "midbrain segment" EXACT [] synonym: "segment of midbrain" EXACT [] is_a: UBERON:0002616 ! regional part of brain intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain [Term] id: UBERON:0003022 name: lobe parts of cerebral cortex synonym: "cerebral cortical segment" RELATED [] synonym: "lobe of cerebral cortex" EXACT [] synonym: "lobes of the brain" RELATED [] synonym: "regional organ part of cerebral cortex" RELATED [] synonym: "segment of cerebral cortex" RELATED [] is_a: UBERON:0002619 ! regional part of cerebral cortex [Term] id: UBERON:0003037 name: septum def: "a wall, dividing a cavity or structure into smaller ones[WP]." [] synonym: "septa" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0003048 name: regional part of hypothalamus def: "A regional part of brain that is part of a hypothalamus [Automatically generated definition]." [] synonym: "hypothalamus segment" EXACT [] synonym: "segment of hypothalamus" EXACT [] is_a: UBERON:0002784 ! regional part of diencephalon intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001898 ! hypothalamus relationship: part_of UBERON:0001898 ! hypothalamus [Term] id: UBERON:0003050 name: olfactory placode def: "A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity." [] synonym: "nasal I placode" RELATED [] synonym: "nasal placode" RELATED [] synonym: "olfactory placodes" EXACT [] synonym: "placoda nasalis" EXACT [] synonym: "placoda olfactoria" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007497 ! developing epithelial placode is_a: UBERON:0009955 ! neurogenic placode is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0002346 ! neurectoderm relationship: part_of UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0003051 name: ear vesicle def: "The saccular invagination of ectoderm from which the vertebrate inner ear develops[BTO]. Epithelial sac present beside the fifth rhombomere; forms the semicircular canals dorsally and the otolith organs ventrally, and houses the acoustico-vestibular sensory epithelia (maculae) of hair cells[ZFA]. epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP]" [] synonym: "acoustic vesicle" RELATED [] synonym: "auditory vesicle" RELATED [] synonym: "otic vesicle" EXACT [] synonym: "otocyst" RELATED [] synonym: "OV" RELATED [] is_a: UBERON:0005085 ! ectodermal placode is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007497 ! developing epithelial placode is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0009123 ! otic cup relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000924 ! ectoderm [Term] id: UBERON:0003055 name: periderm def: "A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis." [] synonym: "epidermis epithelial layer" RELATED [] synonym: "epidermis outer layer" RELATED [] synonym: "EVL" RELATED [] synonym: "periderm" RELATED [] synonym: "skin periderm" EXACT [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0000076 ! external ectoderm relationship: develops_from UBERON:0007383 ! enveloping layer of ectoderm relationship: part_of UBERON:0002199 ! integument [Term] id: UBERON:0003056 name: pre-chordal neural plate def: "The portion of neural plate anterior to the mid-hindbrain junction." [] synonym: "anterior neural plate" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0003075 ! neural plate [Term] id: UBERON:0003057 name: chordal neural plate def: "The portion of neural plate posterior to the mid-hindbrain junction." [] synonym: "posterior neural plate" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0003075 ! neural plate [Term] id: UBERON:0003059 name: presomitic mesoderm def: "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." [] synonym: "presumptive somite mesoderm" RELATED [] synonym: "PSM" RELATED [] synonym: "segmental plate" EXACT [] synonym: "somitogenic mesoderm" RELATED [] synonym: "unsegmented mesenchyme" RELATED [] synonym: "unsegmented paraxial mesoderm" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0007282 ! presumptive segmental plate relationship: part_of UBERON:0003077 ! paraxial mesoderm [Term] id: UBERON:0003060 name: pronephric duct def: "In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP]." [] synonym: "archinephric duct" RELATED [] synonym: "ductus pronephricus" RELATED [] is_a: UBERON:0009201 ! nephric duct is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: develops_from UBERON:0005721 ! pronephric mesoderm relationship: part_of UBERON:0002120 ! pronephros [Term] id: UBERON:0003061 name: blood island def: "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." [] synonym: "blood islands" EXACT [] synonym: "caudal hematopoietic tissue" RELATED [] synonym: "posterior blood island" RELATED [] synonym: "posterior ICM" RELATED [] synonym: "VBI" RELATED [] synonym: "ventral blood island" RELATED [] synonym: "ventral lateral plate mesoderm" BROAD [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0003063 name: prechordal plate def: "a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells[GO]. Axial hypoblast located anterior to the chordamesoderm; the polster is its most anterior region[ZFA]. Uniquely thickened portion of the endoderm that is in contact with ectoderm immediately rostral to the cephalic tip of the notochord[WP]." [] synonym: "head mesenchyme" BROAD [] synonym: "head mesoderm" BROAD [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0003068 ! axial mesoderm [Term] id: UBERON:0003064 name: intermediate mesoderm def: "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [] synonym: "IM" RELATED [] synonym: "intermediate mesenchyme" RELATED [] synonym: "intermediate plate mesoderm" RELATED [] synonym: "mesenchyma intermedium" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000926 ! mesoderm relationship: part_of UBERON:0005256 ! trunk mesenchyme [Term] id: UBERON:0003066 name: pharyngeal arch 2 def: "assists in forming the side and front of the neck." [] synonym: "2nd arch" RELATED [] synonym: "2nd pharyngeal arch" EXACT [] synonym: "2nd visceral arch" RELATED [] synonym: "arcus pharyngeus secundus" EXACT [] synonym: "branchial arch 2" EXACT [] synonym: "hyoid arch" EXACT [] synonym: "hyoid bars" RELATED [] synonym: "pharyngeal arch 2" EXACT [] synonym: "pharyngeal arches 2" RELATED [] synonym: "second branchial arch" EXACT [] synonym: "second pharyngeal arch" EXACT [] synonym: "second visceral arch" EXACT [] synonym: "visceral arch 2" EXACT [] is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0003067 name: dorsolateral placode def: "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." [] synonym: "dorsolateral placodes" EXACT [] is_a: UBERON:0009955 ! neurogenic placode [Term] id: UBERON:0003068 name: axial mesoderm def: "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [] synonym: "chordamesoderm" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000926 ! mesoderm [Term] id: UBERON:0003069 name: otic placode def: "A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK]" [] synonym: "auditory placode" RELATED [] synonym: "ear placode" RELATED [] synonym: "ear/otic placode" RELATED [] synonym: "octaval placode" RELATED [] synonym: "octaval VIII placode" RELATED [] synonym: "placoda otica" EXACT [] is_a: UBERON:0003067 ! dorsolateral placode relationship: part_of UBERON:0001690 ! ear [Term] id: UBERON:0003071 name: eye primordium def: "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." [] synonym: "eye anlage" RELATED [] synonym: "eye field" RELATED [] synonym: "eye placode" EXACT [] synonym: "occular primordium" EXACT [] synonym: "ocular primordium" EXACT [] synonym: "optic field" RELATED [] synonym: "optic placode" EXACT [] synonym: "optic placode of camera-type eye" EXACT [] synonym: "optic placodes" RELATED [] synonym: "optic primordium" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007497 ! developing epithelial placode is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0003056 ! pre-chordal neural plate relationship: part_of UBERON:0003056 ! pre-chordal neural plate [Term] id: UBERON:0003072 name: optic cup def: "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." [] synonym: "eye cup" RELATED [] synonym: "ocular cup" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0004128 ! optic vesicle relationship: part_of UBERON:0010312 ! immature eye [Term] id: UBERON:0003073 name: lens placode def: "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." [] synonym: "placoda lentis" RELATED [] is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0010312 ! immature eye is_a: UBERON:0011814 ! non-neurogenic ectodermal placode relationship: part_of UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0010312 ! immature eye [Term] id: UBERON:0003074 name: mesonephric duct def: "Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA]." [] synonym: "archinephric duct" RELATED [] synonym: "ductus mesonephricus; ductus Wolffi" RELATED [] synonym: "Leydig's duct" RELATED [] synonym: "renal duct" RELATED [] synonym: "Wolffian duct" EXACT [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0009201 ! nephric duct relationship: develops_from UBERON:0003060 ! pronephric duct relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0003075 name: neural plate def: "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]" [] synonym: "lamina neuralis" RELATED [] synonym: "presumptive central nervous system" RELATED [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0002346 ! neurectoderm relationship: develops_from UBERON:0007284 ! presumptive neural plate relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0002346 ! neurectoderm [Term] id: UBERON:0003076 name: posterior neural tube is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003057 ! chordal neural plate relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0003077 name: paraxial mesoderm def: "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]" [] synonym: "mesoderma paraxiale" RELATED [] synonym: "paraxial mesenchyme" EXACT [] synonym: "somitic mesoderm" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue relationship: develops_from UBERON:0007285 ! presumptive paraxial mesoderm relationship: part_of UBERON:0000926 ! mesoderm [Term] id: UBERON:0003080 name: anterior neural tube is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003056 ! pre-chordal neural plate relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0003081 name: lateral plate mesoderm def: "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." [] synonym: "lateral mesoderm" EXACT [] synonym: "lateral plate" RELATED [] synonym: "lateral plate mesenchyme" RELATED [] synonym: "mesoderma laminae lateralis" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000926 ! mesoderm [Term] id: UBERON:0003082 name: myotome def: "A group of tissues formed from somites that develop into the body wall muscle[WP]. Somitic compartment that is a precursor of muscle. mesoderm that is derived from the somite that is fated to become the musculature[MP]. Portion of the somites giving rise to body wall muscle masses[ZFA]" [] synonym: "muscle plate" RELATED [] synonym: "myomere" RELATED [] synonym: "myomeres" EXACT [] synonym: "myotome region" RELATED [] synonym: "myotomes" RELATED [] synonym: "myotomus" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0004290 ! dermomyotome relationship: part_of UBERON:0000926 ! mesoderm [Term] id: UBERON:0003083 name: trunk neural crest def: "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." [] synonym: "trunk crest" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002342 ! neural crest [Term] id: UBERON:0003084 name: heart primordium def: "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." [] synonym: "fused heart primordium" RELATED [] is_a: UBERON:0001048 ! primordium relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: develops_from UBERON:0004140 ! primary heart field relationship: develops_from UBERON:0007005 ! cardiac mesoderm relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0003089 name: sclerotome def: "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." [] synonym: "sclerotomes" EXACT [] synonym: "sclerotomus" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0007530 ! migrating mesenchyme population relationship: develops_from UBERON:0002329 ! somite [Term] id: UBERON:0003091 name: thyroid primordium def: "The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0001048 ! primordium is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0007123 ! pharyngeal pouch 2 relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0003099 name: cranial neural crest def: "The cranial neural crest arises in the anterior and populates the face and the pharyngeal arches giving rise to bones, cartilage, nerves and connective tissue [Wikipedia]." [] synonym: "cephalic neural crest" EXACT [] synonym: "crista neuralis cranialis" RELATED [] synonym: "head crest" RELATED [] synonym: "head neural crest" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002342 ! neural crest [Term] id: UBERON:0003100 name: female organism def: "Gonochoristic organism that can produce female gametes." [] synonym: "female" RELATED [] synonym: "female human body" NARROW [] is_a: UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0003101 name: male organism def: "Gonochoristic organism that can produce male gametes." [] synonym: "male" RELATED [] synonym: "male human body" NARROW [] is_a: UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0003102 name: surface structure def: "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." [] synonym: "anatomical surface feature" EXACT [] synonym: "surface feature" RELATED [] synonym: "surface region" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure relationship: part_of UBERON:0007029 ! external covering of organism [Term] id: UBERON:0003103 name: compound organ def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [] synonym: "organ" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0003104 name: mesenchyme def: "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]." [] synonym: "mesenchyma" RELATED [] synonym: "mesenchymal tissue" EXACT [] synonym: "mesenchyme tissue" EXACT [] synonym: "portion of mesenchymal tissue" EXACT [] synonym: "portion of mesenchyme tissue" EXACT [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0003118 name: aortic arch 1 def: "the vessels formed within the first pair of branchial arches in embryogenesis" [] synonym: "1st aortic arch artery" RELATED [] synonym: "1st arch artery" EXACT [] synonym: "1st branchial arch artery" RELATED [] synonym: "1st pharyngeal arch artery" RELATED [] synonym: "AA1" EXACT [] synonym: "first aortic arch" EXACT [] synonym: "first branchial arch artery" EXACT [] synonym: "mandibular aortic arch" EXACT [] is_a: UBERON:0004363 ! aortic arch intersection_of: UBERON:0004363 ! aortic arch intersection_of: part_of UBERON:0004362 ! pharyngeal arch 1 relationship: part_of UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0003119 name: aortic arch 2 def: "the vessels formed within the second pair of branchial arches in embryogenesis" [] synonym: "2nd aortic arch artery" RELATED [] synonym: "2nd arch artery" EXACT [] synonym: "2nd branchial arch artery" RELATED [] synonym: "2nd pharyngeal arch artery" RELATED [] synonym: "AA2" EXACT [] synonym: "hyoid aortic arch" EXACT [] synonym: "second aortic arch" EXACT [] synonym: "second branchial arch artery" EXACT [] is_a: UBERON:0004363 ! aortic arch intersection_of: UBERON:0004363 ! aortic arch intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2 relationship: part_of UBERON:0003066 ! pharyngeal arch 2 [Term] id: UBERON:0003124 name: chorion def: "The chorion is one of the membranes that exists during pregnancy between the developing fetus and mother. It is formed by extraembryonic mesoderm and the two layers of trophoblast and surrounds the embryo and other membranes. The chorionic villi emerge from the chorion, invade the endometrium, and allow transfer of nutrients from maternal blood to fetal blood." [] synonym: "chorion (vertebrates)" EXACT [] synonym: "chorion frondosum" RELATED [] synonym: "chorionic sac" RELATED [] synonym: "embryonic chorion" EXACT [] synonym: "fetal chorion" EXACT [] synonym: "uterine chorion" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0005971 ! amniotic fold [Term] id: UBERON:0003126 name: trachea def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [] synonym: "cartilaginous trachea" EXACT [] synonym: "tracheal tubule" RELATED [] synonym: "vertebrate trachea" EXACT [] synonym: "windpipe" EXACT [] is_a: UBERON:0000117 ! respiratory tube relationship: develops_from UBERON:0008947 ! respiratory primordium relationship: part_of UBERON:0007196 ! tracheobronchial tree [Term] id: UBERON:0003128 name: cranium def: "Upper portion of the skull that excludes the mandible (when present in the organism)." [] synonym: "bones of cranium" EXACT [] synonym: "calvarium" RELATED [] synonym: "epicranial plate" RELATED [] synonym: "ossa cranii" EXACT [] synonym: "set of bones of cranium" EXACT [] synonym: "skeletal system of head" RELATED [] synonym: "skull minus mandible" EXACT [] synonym: "upper part of skull" EXACT [] is_a: UBERON:0000075 ! subdivision of skeletal system relationship: part_of UBERON:0003129 ! skull [Term] id: UBERON:0003129 name: skull def: "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." [] synonym: "cranial skeleton" RELATED [] synonym: "skeletal system of head" RELATED [] is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0010323 ! cranial skeletal system [Term] id: UBERON:0003133 name: reproductive organ def: "An organ involved in reproduction" [] synonym: "genital organ" EXACT [] synonym: "genitalia" RELATED [] synonym: "reproductive system organ" EXACT [] synonym: "sex organ" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure relationship: part_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0003134 name: female reproductive organ def: "A female organ involved in reproduction" [] synonym: "female organism reproductive organ" EXACT [] synonym: "female organism reproductive structure" EXACT [] synonym: "female organism reproductive system organ" EXACT [] synonym: "female organism sex organ" EXACT [] synonym: "female reproductive gland/organ" EXACT [] synonym: "female reproductive system organ" EXACT [] synonym: "female sex organ" EXACT [] synonym: "reproductive organ of female organism" EXACT [] synonym: "reproductive structure of female organism" EXACT [] synonym: "reproductive system organ of female organism" EXACT [] synonym: "sex organ of female organism" EXACT [] is_a: UBERON:0003133 ! reproductive organ is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003133 ! reproductive organ intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0003100 ! female organism [Term] id: UBERON:0003135 name: male reproductive organ def: "A male organ involved in reproduction" [] synonym: "male organism reproductive organ" EXACT [] synonym: "male organism reproductive structure" EXACT [] synonym: "male organism reproductive system organ" EXACT [] synonym: "male organism sex organ" EXACT [] synonym: "male reproductive gland/organ" EXACT [] synonym: "male reproductive system organ" EXACT [] synonym: "male sex organ" EXACT [] synonym: "reproductive organ of male organism" EXACT [] synonym: "reproductive structure of male organism" EXACT [] synonym: "reproductive system organ of male organism" EXACT [] synonym: "sex organ of male organism" EXACT [] is_a: UBERON:0003133 ! reproductive organ is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0003133 ! reproductive organ intersection_of: part_of UBERON:0003101 ! male organism relationship: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0003101 ! male organism [Term] id: UBERON:0003210 name: blood-cerebrospinal fluid barrier def: "barrier in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood[MP]." [] is_a: UBERON:0000119 ! cell layer [Term] id: UBERON:0003214 name: mammary gland alveolus def: "a sac-like structure that is found in the mature gland[GO]." [] synonym: "alveolus of lactiferous gland" EXACT [] synonym: "alveolus of lobe of breast" EXACT [] synonym: "alveolus of lobe of mammary gland" EXACT [] synonym: "alveolus of mammary gland" EXACT [] synonym: "lactiferous alveolus" EXACT [] synonym: "lactiferous gland alveolus" EXACT [] synonym: "lobe of breast alveolus" EXACT [] synonym: "lobe of mammary gland alveolus" EXACT [] synonym: "mammary alveoli" RELATED [] synonym: "mammary alveolus" EXACT [] is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003215 ! alveolus intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001912 ! lobule of lactiferous gland [Term] id: UBERON:0003215 name: alveolus def: "organ part that has the form of a hollow cavity[WP]." [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0003218 name: ovary septum def: "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." [] is_a: UBERON:0003037 ! septum is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003037 ! septum intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0003220 name: metanephric mesenchyme def: "one of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]" [] synonym: "metanephric blastema" EXACT [] synonym: "metanephric mesoderm" EXACT [] synonym: "metanephrogenic mesenchyme" EXACT [] synonym: "metanephros associated mesenchyme" EXACT [] is_a: UBERON:0003918 ! kidney mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: develops_from UBERON:0003074 ! mesonephric duct relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0003241 name: epithelium of utricle def: "An epithelium that is part of a utricle of membranous labyrinth [Automatically generated definition]." [] synonym: "epithelial tissue of membranous labyrinth utricle" EXACT [] synonym: "epithelial tissue of utricle" EXACT [] synonym: "epithelial tissue of utricle of membranous labyrinth" EXACT [] synonym: "epithelial tissue of utriculus (labyrinthus vestibularis)" EXACT [] synonym: "epithelium of macula of utricle of membranous labyrinth" NARROW [] synonym: "epithelium of membranous labyrinth utricle" EXACT [] synonym: "epithelium of utricle of membranous labyrinth" EXACT [] synonym: "epithelium of utriculus (labyrinthus vestibularis)" EXACT [] synonym: "membranous labyrinth utricle epithelial tissue" EXACT [] synonym: "membranous labyrinth utricle epithelium" EXACT [] synonym: "utricle epithelial tissue" EXACT [] synonym: "utricle epithelium" EXACT [] synonym: "utricle of membranous labyrinth epithelial tissue" EXACT [] synonym: "utricle of membranous labyrinth epithelium" EXACT [] synonym: "utriculus (labyrinthus vestibularis) epithelial tissue" EXACT [] synonym: "utriculus (labyrinthus vestibularis) epithelium" EXACT [] is_a: UBERON:0006932 ! vestibular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001853 ! utricle of membranous labyrinth relationship: part_of UBERON:0001853 ! utricle of membranous labyrinth relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth [Term] id: UBERON:0003242 name: epithelium of saccule def: "An epithelium that is part of a saccule of membranous labyrinth [Automatically generated definition]." [] synonym: "epithelial tissue of membranous labyrinth saccule" EXACT [] synonym: "epithelial tissue of saccule" EXACT [] synonym: "epithelial tissue of saccule of membranous labyrinth" EXACT [] synonym: "epithelial tissue of sacculus (labyrinthus vestibularis)" EXACT [] synonym: "epithelium of macula of saccule of membranous labyrinth" RELATED [] synonym: "epithelium of membranous labyrinth saccule" EXACT [] synonym: "epithelium of saccule of membranous labyrinth" EXACT [] synonym: "epithelium of sacculus (labyrinthus vestibularis)" EXACT [] synonym: "membranous labyrinth saccule epithelial tissue" EXACT [] synonym: "membranous labyrinth saccule epithelium" EXACT [] synonym: "saccule epithelial tissue" EXACT [] synonym: "saccule epithelium" EXACT [] synonym: "saccule of membranous labyrinth epithelial tissue" EXACT [] synonym: "saccule of membranous labyrinth epithelium" EXACT [] synonym: "sacculus (labyrinthus vestibularis) epithelial tissue" EXACT [] synonym: "sacculus (labyrinthus vestibularis) epithelium" EXACT [] is_a: UBERON:0006932 ! vestibular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001854 ! saccule of membranous labyrinth relationship: part_of UBERON:0001854 ! saccule of membranous labyrinth [Term] id: UBERON:0003243 name: epithelium of cochlear duct def: "An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition]." [] synonym: "cochlear duct epithelial tissue" EXACT [] synonym: "cochlear duct epithelium" EXACT [] synonym: "cochlear duct of membranous labyrinth epithelial tissue" EXACT [] synonym: "cochlear duct of membranous labyrinth epithelium" EXACT [] synonym: "epithelial tissue of cochlear duct" EXACT [] synonym: "epithelial tissue of cochlear duct of membranous labyrinth" EXACT [] synonym: "epithelial tissue of Reissner's canal" EXACT [] synonym: "epithelium of cochlear duct of membranous labyrinth" EXACT [] synonym: "epithelium of Reissner's canal" EXACT [] synonym: "Reissner's canal epithelial tissue" EXACT [] synonym: "Reissner's canal epithelium" EXACT [] is_a: UBERON:0006937 ! inner ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth [Term] id: UBERON:0003244 name: epithelium of mammary gland def: "An epithelium that is part of a lactiferous gland [Automatically generated definition]." [] synonym: "epithelial tissue of lactiferous gland" EXACT [] synonym: "epithelial tissue of lobe of breast" EXACT [] synonym: "epithelial tissue of lobe of mammary gland" EXACT [] synonym: "epithelial tissue of mammary gland" EXACT [] synonym: "epithelium of lactiferous gland" EXACT [] synonym: "epithelium of lobe of breast" EXACT [] synonym: "epithelium of lobe of mammary gland" EXACT [] synonym: "lactiferous gland epithelial tissue" EXACT [] synonym: "lactiferous gland epithelium" EXACT [] synonym: "lobe of breast epithelial tissue" EXACT [] synonym: "lobe of breast epithelium" EXACT [] synonym: "lobe of mammary gland epithelial tissue" EXACT [] synonym: "lobe of mammary gland epithelium" EXACT [] synonym: "mammary epithelium" EXACT [] synonym: "mammary gland epithelial tissue" EXACT [] synonym: "mammary gland epithelium" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001911 ! mammary gland relationship: develops_from UBERON:0011272 ! embryonic skin basal layer relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0003249 name: epithelium of otic placode def: "An epithelium that is part of a otic placode [Automatically generated definition]." [] synonym: "epithelial tissue of otic placode" EXACT [] synonym: "otic epithelium" EXACT [] synonym: "otic placode epithelial tissue" EXACT [] synonym: "otic placode epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003069 ! otic placode relationship: part_of UBERON:0003069 ! otic placode [Term] id: UBERON:0003257 name: yolk sac endoderm def: "An extraembryonic structure that develops_from a endoderm and is part of a yolk sac." [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000478 ! extraembryonic structure intersection_of: UBERON:0000478 ! extraembryonic structure intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001040 ! yolk sac relationship: develops_from UBERON:0000925 ! endoderm relationship: part_of UBERON:0001040 ! yolk sac [Term] id: UBERON:0003258 name: endoderm of foregut def: "An endoderm that is part of a foregut [Automatically generated definition]." [] synonym: "foregut endoderm" EXACT [] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001041 ! foregut relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0003259 name: endoderm of midgut def: "An endoderm that is part of a midgut [Automatically generated definition]." [] synonym: "midgut endoderm" EXACT [] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001045 ! midgut relationship: part_of UBERON:0001045 ! midgut [Term] id: UBERON:0003260 name: endoderm of hindgut def: "An endoderm that is part of a hindgut [Automatically generated definition]." [] synonym: "hindgut endoderm" EXACT [] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001046 ! hindgut relationship: part_of UBERON:0001046 ! hindgut [Term] id: UBERON:0003261 name: thyroid primordium endoderm def: "An endoderm that is part of a thyroid primordium." [] synonym: "endoderm of thyroid primordium" EXACT [] is_a: UBERON:0000925 ! endoderm is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0003091 ! thyroid primordium relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm relationship: part_of UBERON:0003091 ! thyroid primordium [Term] id: UBERON:0003262 name: amniotic mesoderm synonym: "amnion mesenchyme" EXACT [] synonym: "amnion mesoderm" EXACT [] synonym: "mesenchyme of amnion" EXACT [] is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000305 ! amnion relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm relationship: part_of UBERON:0000305 ! amnion [Term] id: UBERON:0003264 name: mesoderm of yolk sac def: "A mesoderm that is part of a yolk sac [Automatically generated definition]." [] synonym: "yolk sac mesoderm" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000926 ! mesoderm intersection_of: UBERON:0000926 ! mesoderm intersection_of: part_of UBERON:0001040 ! yolk sac relationship: part_of UBERON:0001040 ! yolk sac [Term] id: UBERON:0003265 name: chorionic mesenchyme synonym: "chorion mesenchyme" EXACT [] synonym: "chorion mesoderm" EXACT [] synonym: "chorionic mesenchyme" EXACT [] synonym: "mesenchyme of chorion" EXACT [] synonym: "mesenchyme of chorion (vertebrates)" EXACT [] is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0003124 ! chorion relationship: develops_from UBERON:0004871 ! somatic layer of lateral plate mesoderm relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm relationship: part_of UBERON:0003124 ! chorion [Term] id: UBERON:0003269 name: skeletal muscle tissue of eye def: "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." [] synonym: "eye skeletal muscle" EXACT [] synonym: "eye skeletal muscle group" RELATED [] synonym: "eye skeletal muscle tissue" EXACT [] synonym: "skeletal muscle tissue of eye" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003273 name: skeletal muscle tissue of tongue def: "A portion of skeletal muscle tissue that is part of a tongue [Automatically generated definition]." [] synonym: "skeletal muscle tissue of tongue" EXACT [] synonym: "tongue skeletal muscle" EXACT [] synonym: "tongue skeletal muscle tissue" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001723 ! tongue relationship: develops_from UBERON:0005594 ! head somite relationship: part_of UBERON:0000378 ! tongue muscle relationship: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0004477 ! tongue musculature [Term] id: UBERON:0003276 name: skeleton of embryo def: "A skeletal system that is part of a embryo [Automatically generated definition]." [] synonym: "developmental tissue set of all bones" EXACT [] synonym: "developmental tissue set of bones of body" EXACT [] synonym: "developmental tissue skeletal system" EXACT [] synonym: "developmental tissue skeleton" EXACT [] synonym: "developmental tissue skeleton system" EXACT [] synonym: "embryo set of all bones" EXACT [] synonym: "embryo set of bones of body" EXACT [] synonym: "embryo skeletal system" EXACT [] synonym: "embryo skeleton" EXACT [] synonym: "embryo skeleton system" EXACT [] synonym: "set of all bones of developmental tissue" EXACT [] synonym: "set of all bones of embryo" EXACT [] synonym: "set of bones of body of developmental tissue" EXACT [] synonym: "set of bones of body of embryo" EXACT [] synonym: "skeletal system of developmental tissue" EXACT [] synonym: "skeletal system of embryo" EXACT [] synonym: "skeleton of developmental tissue" EXACT [] synonym: "skeleton system of developmental tissue" EXACT [] synonym: "skeleton system of embryo" EXACT [] is_a: UBERON:0001434 ! skeletal system is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0001434 ! skeletal system intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0003279 name: endothelium of trachea def: "An endothelium that is part of a trachea." [] synonym: "endothelium of windpipe" EXACT [] synonym: "trachea endothelium" EXACT [] synonym: "windpipe endothelium" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001901 ! epithelium of trachea is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003281 name: mesentery of stomach def: "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." [] synonym: "mesentery of ventriculus" EXACT [] synonym: "mesogaster" EXACT [] synonym: "mesogastium" EXACT [] synonym: "mesogastrium" EXACT [] synonym: "stomach mesentery" EXACT [] synonym: "ventriculus mesentery" EXACT [] is_a: UBERON:0004854 ! gastrointestinal system mesentery is_a: UBERON:0009034 ! stomach region intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: UBERON:0003282 name: mesentery of heart def: "A mesentery that surrounds the heart." [] synonym: "heart mesentery" EXACT [] synonym: "mesocardium" RELATED [] is_a: UBERON:0002095 ! mesentery is_a: UBERON:0005983 ! heart layer intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0003283 name: mesentery of oesophagus def: "A mesentery that is part of a esophagus [Automatically generated definition]." [] synonym: "esophagus mesentery" EXACT [] synonym: "gullet mesentery" EXACT [] synonym: "mesentery of esophagus" EXACT [] synonym: "mesentery of gullet" EXACT [] synonym: "oesophagus mesentery" EXACT [] is_a: UBERON:0001975 ! serosa of esophagus is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus [Term] id: UBERON:0003284 name: mesentery of midgut def: "A mesentery that is part of a midgut [Automatically generated definition]." [] synonym: "midgut mesentery" EXACT [] is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001045 ! midgut relationship: part_of UBERON:0001045 ! midgut [Term] id: UBERON:0003288 name: meninx of midbrain def: "A meninx that is part of a midbrain [Automatically generated definition]." [] synonym: "meninges of midbrain" EXACT [] synonym: "mesencephalon meninges" RELATED [] synonym: "midbrain meninges" EXACT [] synonym: "midbrain meninx" EXACT [] is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain [Term] id: UBERON:0003289 name: meninx of telencephalon def: "A meninx that is part of a telencephalon [Automatically generated definition]." [] synonym: "meninges of telencephalon" EXACT [] synonym: "telencephalon meninges" EXACT [] synonym: "telencephalon meninx" EXACT [] is_a: UBERON:0003548 ! forebrain meninges is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0003290 name: meninx of diencephalon def: "A meninx that is part of a diencephalon [Automatically generated definition]." [] synonym: "between brain meninges" EXACT [] synonym: "between brain meninx" EXACT [] synonym: "diencephalon meninges" EXACT [] synonym: "diencephalon meninx" EXACT [] synonym: "interbrain meninges" EXACT [] synonym: "interbrain meninx" EXACT [] synonym: "mature diencephalon meninges" EXACT [] synonym: "mature diencephalon meninx" EXACT [] synonym: "meninges of between brain" EXACT [] synonym: "meninges of diencephalon" EXACT [] synonym: "meninges of interbrain" EXACT [] synonym: "meninges of mature diencephalon" EXACT [] synonym: "meninx of between brain" EXACT [] synonym: "meninx of interbrain" EXACT [] synonym: "meninx of mature diencephalon" EXACT [] is_a: UBERON:0003548 ! forebrain meninges intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0003291 name: meninx of hindbrain def: "A meninx that is part of a hindbrain [Automatically generated definition]." [] synonym: "hindbrain meninges" EXACT [] synonym: "hindbrain meninx" EXACT [] synonym: "meninges of hindbrain" EXACT [] synonym: "rhomencephalon meninges" RELATED [] is_a: UBERON:0003547 ! brain meninx is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0003292 name: meninx of spinal cord def: "A meninx that is part of a spinal cord [Automatically generated definition]." [] synonym: "menines of spinal cord" EXACT [] synonym: "meninges of spinal cord" EXACT [] synonym: "spinal cord meninges" EXACT [] synonym: "spinal cord meninx" EXACT [] synonym: "spinal meninges" EXACT [] synonym: "spinal meninx" EXACT [] is_a: UBERON:0002360 ! meninx is_a: UBERON:0005174 ! dorsal region organ intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0003294 name: gland of foregut def: "A gland that is part of a foregut [Automatically generated definition]." [] synonym: "foregut gland" EXACT [] is_a: UBERON:0003408 ! gland of gut intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001041 ! foregut relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0003295 name: pharyngeal gland def: "Racemose mucous glands beneath the mucous membrane of the pharynx." [] synonym: "glandulae pharyngeae" RELATED [] synonym: "pharynx gland" EXACT [] is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0003296 name: gland of diencephalon def: "A gland that is part of a diencephalon [Automatically generated definition]." [] synonym: "between brain gland" EXACT [] synonym: "diencephalon gland" EXACT [] synonym: "gland of between brain" EXACT [] synonym: "gland of interbrain" EXACT [] synonym: "gland of mature diencephalon" EXACT [] synonym: "interbrain gland" EXACT [] synonym: "mature diencephalon gland" EXACT [] is_a: UBERON:0002530 ! gland is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0003297 name: gland of integumental system def: "A gland that is part of a integumental system [Automatically generated definition]." [] synonym: "integumental system gland" EXACT [] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002416 ! integumental system relationship: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0003304 name: mesoderm blood island def: "A blood island that is part of a mesoderm." [] synonym: "mesenchyme blood island" RELATED [] synonym: "mesoderm blood islands" EXACT [] is_a: UBERON:0003061 ! blood island is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007497 ! developing epithelial placode is_a: UBERON:0007503 ! epithelial vesicle is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0012429 ! hemopoietic tissue intersection_of: UBERON:0003061 ! blood island intersection_of: part_of UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000926 ! mesoderm relationship: part_of UBERON:0007798 ! vascular system [Term] id: UBERON:0003312 name: mesenchyme of testis def: "Mesenchyme that is part of a testis [Automatically generated definition]." [] synonym: "testis mesenchyme" EXACT [] is_a: UBERON:0003855 ! gonad mesenchyme is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000473 ! testis relationship: part_of UBERON:0000473 ! testis [Term] id: UBERON:0003314 name: eye mesenchyme def: "Mesenchyme that is part of a camera-type eye." [] synonym: "mesenchyme of eye" EXACT [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0010312 ! immature eye intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0009920 ! optic neural crest relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003315 name: mesenchyme of ovary def: "Mesenchyme that is part of a ovary [Automatically generated definition]." [] synonym: "female reproductive system gonad mesenchyme" EXACT [] synonym: "female reproductive system gonada mesenchyme" EXACT [] synonym: "gonad of female reproductive system mesenchyme" EXACT [] synonym: "gonada of female reproductive system mesenchyme" EXACT [] synonym: "mesenchyme of female reproductive system gonad" EXACT [] synonym: "mesenchyme of female reproductive system gonada" EXACT [] synonym: "mesenchyme of gonad of female reproductive system" EXACT [] synonym: "mesenchyme of gonada of female reproductive system" EXACT [] synonym: "ovary mesenchyme" EXACT [] is_a: UBERON:0003855 ! gonad mesenchyme is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0003316 name: mesenchyme of yolk sac def: "Mesenchyme that is part of a yolk sac [Automatically generated definition]." [] synonym: "yolk sac mesenchyme" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001040 ! yolk sac relationship: part_of UBERON:0001040 ! yolk sac [Term] id: UBERON:0003326 name: mesenchyme of mammary gland def: "Mesenchyme that is part of a mammary gland." [] synonym: "lactiferous gland mesenchyme" EXACT [] synonym: "lobe of breast mesenchyme" EXACT [] synonym: "lobe of mammary gland mesenchyme" EXACT [] synonym: "mammary gland mesenchyme" EXACT [] synonym: "mammary mesenchyme" EXACT [] synonym: "mesenchyme of lactiferous gland" EXACT [] synonym: "mesenchyme of lobe of breast" EXACT [] synonym: "mesenchyme of lobe of mammary gland" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0003329 name: submucosa of anal canal def: "A submucosa that is part of an anal canal [Automatically generated definition]." [] synonym: "anal canal submucosa" EXACT [] synonym: "anal canal viewed anatomically submucosa" EXACT [] synonym: "anal region submucosa" EXACT [] synonym: "anatomical anal canal submucosa" EXACT [] synonym: "submucosa of anal canal viewed anatomically" EXACT [] synonym: "submucosa of anal region" EXACT [] synonym: "submucosa of anatomical anal canal" EXACT [] is_a: UBERON:0001208 ! submucosa of large intestine is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal [Term] id: UBERON:0003330 name: submucosa of rectum def: "The submucous layer of the wall of the rectum." [] synonym: "rectal submucosa" EXACT [] synonym: "rectum submucosa" EXACT [] synonym: "tela submucosa recti" EXACT [] is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003331 name: submucosa of colon def: "A submucosa that is part of a colon [Automatically generated definition]." [] synonym: "colon submucosa" EXACT [] synonym: "colonic submucosa" EXACT [] synonym: "large bowel submucosa" EXACT [] synonym: "submucosa of large bowel" EXACT [] is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0003332 name: submucosa of duodenum def: "A submucosa that is part of a duodenum [Automatically generated definition]." [] synonym: "doudenal submucosa" EXACT [] synonym: "duodenal submucosa" EXACT [] synonym: "duodenum submucosa" EXACT [] is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: UBERON:0003333 name: submucosa of jejunum def: "A submucosa that is part of a jejunum [Automatically generated definition]." [] synonym: "jejunal submucosa" EXACT [] synonym: "jejunum submucosa" EXACT [] is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0003334 name: serosa of rectum def: "A serous membrane that is part of a rectum [Automatically generated definition]." [] synonym: "rectal serosa" EXACT [] synonym: "rectum serosa" EXACT [] synonym: "rectum serous membrane" EXACT [] synonym: "serous membrane of rectum" EXACT [] synonym: "visceral peritoneum of rectum" EXACT [] is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003335 name: serosa of colon def: "A serous membrane that is part of a colon [Automatically generated definition]." [] synonym: "colon serosa" EXACT [] synonym: "colon serous membrane" EXACT [] synonym: "colonic serosa" EXACT [] synonym: "large bowel serosa" EXACT [] synonym: "large bowel serous membrane" EXACT [] synonym: "serosa of large bowel" EXACT [] synonym: "serous membrane of colon" EXACT [] synonym: "serous membrane of large bowel" EXACT [] synonym: "visceral peritoneum of colon" EXACT [] is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0003336 name: serosa of duodenum def: "A serous membrane that is part of a duodenum [Automatically generated definition]." [] synonym: "doudenal serosa" EXACT [] synonym: "duodenal serosa" EXACT [] synonym: "duodenum serosa" EXACT [] synonym: "duodenum serous membrane" EXACT [] synonym: "serous membrane of duodenum" EXACT [] synonym: "visceral peritoneum of duodenum" EXACT [] is_a: UBERON:0001206 ! serosa of small intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: UBERON:0003337 name: serosa of jejunum def: "A serous membrane that is part of a jejunum [Automatically generated definition]." [] synonym: "jejunal serosa" EXACT [] synonym: "jejunum serosa" EXACT [] synonym: "jejunum serous membrane" EXACT [] synonym: "serous membrane of jejunum" EXACT [] synonym: "visceral peritoneum of jejunum" EXACT [] is_a: UBERON:0001206 ! serosa of small intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0003338 name: ganglion of peripheral nervous system def: "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." [] synonym: "peripheral nervous system ganglion" EXACT [] is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0003339 name: ganglion of central nervous system def: "A ganglion that is part of a central nervous system [Automatically generated definition]." [] synonym: "central nervous system ganglion" EXACT [] synonym: "ganglion of neuraxis" EXACT [] synonym: "neuraxis ganglion" EXACT [] is_a: UBERON:0000045 ! ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0003342 name: mucosa of anal canal def: "A mucosa that is part of an anal canal [Automatically generated definition]." [] synonym: "anal canal mucosa" EXACT [] synonym: "anal canal mucosa of organ" EXACT [] synonym: "anal canal mucous membrane" EXACT [] synonym: "anal canal organ mucosa" EXACT [] synonym: "anal canal viewed anatomically mucosa" EXACT [] synonym: "anal canal viewed anatomically mucosa of organ" EXACT [] synonym: "anal canal viewed anatomically mucous membrane" EXACT [] synonym: "anal canal viewed anatomically organ mucosa" EXACT [] synonym: "anal mucosa" EXACT [] synonym: "anal mucous membrane" EXACT [] synonym: "anal region mucosa" EXACT [] synonym: "anal region mucosa of organ" EXACT [] synonym: "anal region mucous membrane" EXACT [] synonym: "anal region organ mucosa" EXACT [] synonym: "anatomical anal canal mucosa" EXACT [] synonym: "anatomical anal canal mucosa of organ" EXACT [] synonym: "anatomical anal canal mucous membrane" EXACT [] synonym: "anatomical anal canal organ mucosa" EXACT [] synonym: "mucosa of anal canal viewed anatomically" EXACT [] synonym: "mucosa of anal region" EXACT [] synonym: "mucosa of anatomical anal canal" EXACT [] synonym: "mucosa of organ of anal canal" EXACT [] synonym: "mucosa of organ of anal canal viewed anatomically" EXACT [] synonym: "mucosa of organ of anal region" EXACT [] synonym: "mucosa of organ of anatomical anal canal" EXACT [] synonym: "mucous membrane of anal canal" EXACT [] synonym: "mucous membrane of anal canal viewed anatomically" EXACT [] synonym: "mucous membrane of anal region" EXACT [] synonym: "mucous membrane of anatomical anal canal" EXACT [] synonym: "organ mucosa of anal canal" EXACT [] synonym: "organ mucosa of anal canal viewed anatomically" EXACT [] synonym: "organ mucosa of anal region" EXACT [] synonym: "organ mucosa of anatomical anal canal" EXACT [] is_a: UBERON:0001207 ! mucosa of large intestine is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal [Term] id: UBERON:0003346 name: mucosa of rectum def: "A mucosa that is part of a rectum [Automatically generated definition]." [] synonym: "mucosa of organ of rectum" EXACT [] synonym: "mucous membrane of rectum" EXACT [] synonym: "organ mucosa of rectum" EXACT [] synonym: "rectal mucosa" EXACT [] synonym: "rectal mucous membrane" EXACT [] synonym: "rectum mucosa" EXACT [] synonym: "rectum mucosa of organ" EXACT [] synonym: "rectum mucous membrane" EXACT [] synonym: "rectum organ mucosa" EXACT [] is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003350 name: epithelium of mucosa def: "A layer of epithelial cells on the surface of the mucosa." [] synonym: "lamina epithelialis mucosa" RELATED [] synonym: "lamina epithelialis mucosae" RELATED [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000344 ! mucosa relationship: part_of UBERON:0000344 ! mucosa [Term] id: UBERON:0003351 name: pharyngeal epithelium def: "An epithelium that is part of a pharynx [Automatically generated definition]." [] synonym: "epithelial tissue of pharynx" EXACT [] synonym: "epithelium of pharynx" EXACT [] synonym: "pharynx epithelial tissue" EXACT [] synonym: "pharynx epithelium" EXACT [] is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0003352 name: epithelium of midgut def: "An epithelium that is part of a midgut." [] synonym: "epithelial tissue of midgut" EXACT [] synonym: "midgut epithelial tissue" EXACT [] synonym: "midgut epithelium" EXACT [] is_a: UBERON:0003929 ! gut epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001045 ! midgut relationship: part_of UBERON:0001045 ! midgut [Term] id: UBERON:0003353 name: epithelium of hindgut def: "An epithelium that is part of a hindgut [Automatically generated definition]." [] synonym: "epithelial tissue of hindgut" EXACT [] synonym: "hindgut epithelial tissue" EXACT [] synonym: "hindgut epithelium" EXACT [] is_a: UBERON:0003929 ! gut epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001046 ! hindgut relationship: part_of UBERON:0001046 ! hindgut [Term] id: UBERON:0003354 name: epithelium of rectum def: "An epithelium that is part of a rectum [Automatically generated definition]." [] synonym: "epithelial tissue of rectum" EXACT [] synonym: "rectal epithelium" EXACT [] synonym: "rectum epithelial tissue" EXACT [] synonym: "rectum epithelium" EXACT [] is_a: UBERON:0001278 ! epithelium of large intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003357 name: epithelium of tongue def: "An epithelium that is part of a tongue [Automatically generated definition]." [] synonym: "epithelial tissue of tongue" EXACT [] synonym: "lingual epithelium" RELATED [] synonym: "tongue epithelial tissue" EXACT [] synonym: "tongue epithelium" EXACT [] is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0003367 name: epithelium of vomeronasal organ def: "An epithelium that is part of a vomeronasal organ [Automatically generated definition]." [] synonym: "epithelial tissue of Jacobson's organ" EXACT [] synonym: "epithelial tissue of vomeronasal organ" EXACT [] synonym: "epithelium of Jacobson's organ" EXACT [] synonym: "Jacobson's organ epithelial tissue" EXACT [] synonym: "Jacobson's organ epithelium" EXACT [] synonym: "vomeronasal epithelium" EXACT [] synonym: "vomeronasal organ epithelial tissue" EXACT [] synonym: "vomeronasal organ epithelium" EXACT [] synonym: "vomeronasal organ sensory epithelium" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002255 ! vomeronasal organ relationship: develops_from UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0002255 ! vomeronasal organ [Term] id: UBERON:0003374 name: chorionic ectoderm synonym: "chorion ectoderm" EXACT [] synonym: "chorion epithelium" RELATED [] synonym: "chorionic epithelium" RELATED [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000478 ! extraembryonic structure intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0003124 ! chorion relationship: develops_from UBERON:0000924 ! ectoderm relationship: part_of UBERON:0003124 ! chorion [Term] id: UBERON:0003381 name: cardiac muscle of right ventricle def: "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [] synonym: "cardiac muscle tissue of right ventricle" EXACT [] synonym: "right ventricle cardiac muscle" RELATED [] synonym: "right ventricular cardiac muscle tissue" EXACT [] is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0003382 name: cardiac muscle of left ventricle def: "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [] synonym: "cardiac muscle tissue of left ventricle" EXACT [] synonym: "left ventricle cardiac muscle" RELATED [] synonym: "left ventricular cardiac muscle tissue" EXACT [] is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0003383 name: cardiac muscle of interventricular septum def: "A portion of cardiac muscle tissue that is part of a interventricular septum [Automatically generated definition]." [] synonym: "cardiac muscle tissue of interventricular septum" EXACT [] synonym: "interventricular septum cardiac muscle" EXACT [] synonym: "interventricular septum heart muscle" EXACT [] synonym: "interventricular septum myocardium" EXACT [] is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum is_a: UBERON:0004667 ! interventricular septum muscular part intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: UBERON:0003384 name: skeletal muscle tissue of pharynx def: "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." [] synonym: "pharynx skeletal muscle" EXACT [] synonym: "pharynx skeletal muscle tissue" EXACT [] synonym: "skeletal muscle tissue of pharynx" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0003386 name: smooth muscle of eye def: "A portion of smooth muscle tissue that is part of a eye [Automatically generated definition]." [] synonym: "ocular smooth muscle" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003387 name: smooth muscle of trachea def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." [] synonym: "trachea smooth muscle" EXACT [] synonym: "tracheal smooth muscle" EXACT [] is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003393 name: mesentery of urinary system def: "A mesentery that is part of a urinary system [Automatically generated definition]." [] synonym: "excretory system mesentery" EXACT [] synonym: "mesentery of excretory system" EXACT [] synonym: "mesentery of renal system" EXACT [] synonym: "mesentery of systema urinaria" EXACT [] synonym: "renal system mesentery" EXACT [] synonym: "systema urinaria mesentery" EXACT [] synonym: "urinary system mesentery" EXACT [] is_a: UBERON:0002095 ! mesentery is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0003394 name: mesentery of hindgut def: "A mesentery that is part of a hindgut [Automatically generated definition]." [] synonym: "hindgut mesentery" EXACT [] is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001046 ! hindgut relationship: part_of UBERON:0001046 ! hindgut [Term] id: UBERON:0003395 name: mesentery of rectum def: "A mesentery that is part of a rectum [Automatically generated definition]." [] synonym: "rectum mesentery" EXACT [] is_a: UBERON:0003334 ! serosa of rectum is_a: UBERON:0004854 ! gastrointestinal system mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003396 name: mesentery of colon def: "A mesentery that is part of a colon [Automatically generated definition]." [] synonym: "colon mesentery" EXACT [] synonym: "large bowel mesentery" EXACT [] synonym: "large intestinal mesentery" EXACT [] synonym: "mesentery of large bowel" EXACT [] synonym: "mesentery of large intestine" EXACT [] is_a: UBERON:0003335 ! serosa of colon is_a: UBERON:0004854 ! gastrointestinal system mesentery is_a: UBERON:0007826 ! peritoneal mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0003397 name: mesentery of duodenum def: "A mesentery that is part of a duodenum [Automatically generated definition]." [] synonym: "duodenum mesentery" EXACT [] is_a: UBERON:0001170 ! mesentery of small intestine is_a: UBERON:0003336 ! serosa of duodenum intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: UBERON:0003398 name: mesentery of jejunum def: "A mesentery that is part of a jejunum [Automatically generated definition]." [] synonym: "jejunal mesentery" EXACT [] synonym: "jejunum mesentery" EXACT [] synonym: "mesojejunum" EXACT [] is_a: UBERON:0001170 ! mesentery of small intestine is_a: UBERON:0003337 ! serosa of jejunum intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0003406 name: cartilage of respiratory system def: "A cartilage element that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius cartilage" EXACT [] synonym: "cartilage of apparatus respiratorius" EXACT [] synonym: "respiratory system cartilage" EXACT [] is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003408 name: gland of gut def: "A gland that is part of a digestive tract [Automatically generated definition]." [] synonym: "digestive tract gland" EXACT [] synonym: "gland of digestive tract" EXACT [] synonym: "gland of lower gastrointestinal tract" EXACT [] synonym: "gut gland" EXACT [] synonym: "lower gastrointestinal tract gland" EXACT [] is_a: UBERON:0002530 ! gland is_a: UBERON:0013765 ! digestive system organ intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0003409 name: gland of tongue def: "A gland that is part of a tongue [Automatically generated definition]." [] synonym: "tongue gland" EXACT [] is_a: UBERON:0010047 ! oral gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0003416 name: mesenchyme of tongue def: "Mesenchyme that is part of a tongue [Automatically generated definition]." [] synonym: "tongue mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0003421 name: mesenchyme of vomeronasal organ def: "Mesenchyme that is part of a vomeronasal organ [Automatically generated definition]." [] synonym: "Jacobson's organ mesenchyme" EXACT [] synonym: "mesenchyme of Jacobson's organ" EXACT [] synonym: "vomeronasal mesenchyme" EXACT [] synonym: "vomeronasal organ mesenchyme" EXACT [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0002255 ! vomeronasal organ relationship: develops_from UBERON:0009204 ! medial nasal process mesenchyme relationship: part_of UBERON:0002255 ! vomeronasal organ [Term] id: UBERON:0003422 name: mesenchyme of umbilical cord def: "a gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP]" [] synonym: "umbilical cord mesenchyme" EXACT [] synonym: "Wharton's jelly" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0002331 ! umbilical cord [Term] id: UBERON:0003425 name: renal lymph node def: "A lymph node that is part of a kidney [Automatically generated definition]." [] synonym: "kidney lymph node" EXACT [] synonym: "lymph node of kidney" EXACT [] is_a: UBERON:0002507 ! abdominal lymph node is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000029 ! lymph node intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0003426 name: dermis adipose tissue def: "An adipose tissue that is part of a dermis [Automatically generated definition]." [] synonym: "adipose tissue of dermis" EXACT [] synonym: "dermis fat tissue" EXACT [] synonym: "dermis fatty tissue" EXACT [] synonym: "fat tissue of dermis" EXACT [] synonym: "fatty tissue of dermis" EXACT [] is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003585 ! dermis connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis [Term] id: UBERON:0003429 name: abdomen nerve def: "A nerve that is part of an abdomen [Automatically generated definition]." [] synonym: "nerve of abdomen" EXACT [] is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003430 name: neck nerve def: "A nerve that is part of a neck [Automatically generated definition]." [] synonym: "neck (volume) nerve" EXACT [] synonym: "nerve of neck" EXACT [] synonym: "nerve of neck (volume)" EXACT [] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003432 name: chest nerve def: "A nerve that is part of a chest [Automatically generated definition]." [] synonym: "anterior thoracic region nerve" EXACT [] synonym: "anterolateral part of thorax nerve" EXACT [] synonym: "front of thorax nerve" EXACT [] synonym: "nerve of anterior thoracic region" EXACT [] synonym: "nerve of anterolateral part of thorax" EXACT [] synonym: "nerve of chest" EXACT [] synonym: "nerve of front of thorax" EXACT [] is_a: UBERON:0003824 ! nerve of thoracic segment intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0003437 name: eyelid nerve def: "A nerve that is part of a eyelid [Automatically generated definition]." [] synonym: "blepharon nerve" EXACT [] synonym: "nerve of blepharon" EXACT [] synonym: "nerve of eyelid" EXACT [] is_a: UBERON:0001647 ! facial nerve is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0003438 name: iris nerve def: "A nerve that is part of a iris [Automatically generated definition]." [] synonym: "nerve of iris" EXACT [] is_a: UBERON:0001647 ! facial nerve is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0003439 name: nerve of trunk region def: "A nerve that is part of a trunk [Automatically generated definition]." [] synonym: "nerve of torso" EXACT [] synonym: "nerve of trunk" EXACT [] synonym: "torso nerve" EXACT [] synonym: "trunk nerve" EXACT [] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003444 name: pelvis nerve def: "A nerve that is part of a pelvis [Automatically generated definition]." [] synonym: "nerve of pelvis" EXACT [] is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002355 ! pelvis relationship: part_of UBERON:0002355 ! pelvis [Term] id: UBERON:0003453 name: large intestine Peyer's patch def: "A Peyer's patch that is part of a large intestine." [] synonym: "large intestine Peyer's patch" EXACT [] synonym: "Peyer's patch of large intestine" EXACT [] synonym: "solitary lymphatic follicle of large intestine" RELATED [] synonym: "solitary lymphoid follicle of subdivision of large intestine" RELATED [] is_a: UBERON:0001211 ! Peyer's patch intersection_of: UBERON:0001211 ! Peyer's patch intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine [Term] id: UBERON:0003454 name: small intestine Peyer's patch def: "nodular lymphoid structures on the serosal surface of the small intestine." [] synonym: "aggregated lymphoid follicle of small intestine" EXACT [] synonym: "Peyer's patch" BROAD [] synonym: "Peyer's patch of small bowel" EXACT [] synonym: "Peyer's patch of small intestine" EXACT [] synonym: "small bowel Peyer's patch" EXACT [] synonym: "small intestine Peyer's patch" EXACT [] is_a: UBERON:0001211 ! Peyer's patch intersection_of: UBERON:0001211 ! Peyer's patch intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001204 ! mucosa of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0003455 name: inner renal medulla loop of henle def: "A loop of Henle that is part of a inner medulla of kidney [Automatically generated definition]." [] synonym: "Henle loop of inner medulla of kidney" EXACT [] synonym: "Henle loop of inner renal medulla" EXACT [] synonym: "Henle loop of inner zone of medulla of kidney" EXACT [] synonym: "Henle loop of inner zone of renal medulla" EXACT [] synonym: "henle's loop of inner medulla of kidney" EXACT [] synonym: "henle's loop of inner renal medulla" EXACT [] synonym: "henle's loop of inner zone of medulla of kidney" EXACT [] synonym: "henle's loop of inner zone of renal medulla" EXACT [] synonym: "inner medulla of kidney Henle loop" EXACT [] synonym: "inner medulla of kidney henle's loop" EXACT [] synonym: "inner medulla of kidney loop of Henle" EXACT [] synonym: "inner renal medulla Henle loop" EXACT [] synonym: "inner renal medulla henle's loop" EXACT [] synonym: "inner renal medulla loop of Henle" EXACT [] synonym: "inner zone of medulla of kidney Henle loop" EXACT [] synonym: "inner zone of medulla of kidney henle's loop" EXACT [] synonym: "inner zone of medulla of kidney loop of Henle" EXACT [] synonym: "inner zone of renal medulla Henle loop" EXACT [] synonym: "inner zone of renal medulla henle's loop" EXACT [] synonym: "inner zone of renal medulla loop of Henle" EXACT [] synonym: "kidney inner medulla loop of henle" EXACT [] synonym: "loop of Henle of inner medulla of kidney" EXACT [] synonym: "loop of Henle of inner renal medulla" EXACT [] synonym: "loop of Henle of inner zone of medulla of kidney" EXACT [] synonym: "loop of Henle of inner zone of renal medulla" EXACT [] is_a: UBERON:0001288 ! loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: UBERON:0003456 name: respiratory system lymphatic vessel def: "A lymphatic vessel that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius lymph vessel" EXACT [] synonym: "apparatus respiratorius lymphatic vessel" EXACT [] synonym: "lymph vessel of apparatus respiratorius" EXACT [] synonym: "lymph vessel of respiratory system" EXACT [] synonym: "lymphatic vessel of apparatus respiratorius" EXACT [] synonym: "lymphatic vessel of respiratory system" EXACT [] synonym: "respiratory system lymph vessel" EXACT [] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003457 name: head bone def: "A bone that is part of a head [Automatically generated definition]." [] synonym: "adult head bone" EXACT [] synonym: "adult head bone organ" EXACT [] synonym: "bone of adult head" EXACT [] synonym: "bone of head" EXACT [] synonym: "bone organ of adult head" EXACT [] synonym: "bone organ of head" EXACT [] synonym: "craniofacial bone" RELATED [] synonym: "head bone organ" EXACT [] is_a: UBERON:0007914 ! head or neck bone intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0003458 name: neck bone def: "A bone that is part of a neck [Automatically generated definition]." [] synonym: "bone of neck" EXACT [] synonym: "bone of neck (volume)" EXACT [] synonym: "bone organ of neck" EXACT [] synonym: "bone organ of neck (volume)" EXACT [] synonym: "neck (volume) bone" EXACT [] synonym: "neck (volume) bone organ" EXACT [] synonym: "neck bone organ" EXACT [] is_a: UBERON:0007914 ! head or neck bone intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003459 name: chest bone def: "A bone that is part of a chest [Automatically generated definition]." [] synonym: "anterior thoracic region bone" EXACT [] synonym: "anterior thoracic region bone organ" EXACT [] synonym: "anterolateral part of thorax bone" EXACT [] synonym: "anterolateral part of thorax bone organ" EXACT [] synonym: "bone of anterior thoracic region" EXACT [] synonym: "bone of anterolateral part of thorax" EXACT [] synonym: "bone of chest" EXACT [] synonym: "bone of front of thorax" EXACT [] synonym: "bone organ of anterior thoracic region" EXACT [] synonym: "bone organ of anterolateral part of thorax" EXACT [] synonym: "bone organ of chest" EXACT [] synonym: "bone organ of front of thorax" EXACT [] synonym: "chest bone organ" EXACT [] synonym: "front of thorax bone" EXACT [] synonym: "front of thorax bone organ" EXACT [] is_a: UBERON:0003827 ! thoracic segment bone is_a: UBERON:0005175 ! chest organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0003462 name: facial bone def: "A bone that is part of a facial skeleton [Automatically generated definition]." [] synonym: "bone of facial skeleton" EXACT [] synonym: "bone of viscerocranium" EXACT [] synonym: "facial bone" EXACT [] synonym: "facial skeleton bone" EXACT [] synonym: "viscerocranium bone" EXACT [] is_a: UBERON:0003457 ! head bone is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0011156 ! facial skeleton relationship: part_of UBERON:0011156 ! facial skeleton [Term] id: UBERON:0003463 name: trunk bone def: "A bone that is part of a trunk [Automatically generated definition]." [] synonym: "bone of torso" EXACT [] synonym: "bone of trunk" EXACT [] synonym: "bone organ of torso" EXACT [] synonym: "bone organ of trunk" EXACT [] synonym: "torso bone" EXACT [] synonym: "torso bone organ" EXACT [] synonym: "trunk bone organ" EXACT [] is_a: UBERON:0001474 ! bone element is_a: UBERON:0005177 ! trunk organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003469 name: respiratory system artery def: "An artery that is part of a respiratory system [Automatically generated definition]." [] is_a: UBERON:0001637 ! artery is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003475 name: ureteric vein def: "A vein that is part of a ureter [Automatically generated definition]." [] synonym: "ureter vein" EXACT [] synonym: "vein of ureter" EXACT [] is_a: UBERON:0001638 ! vein is_a: UBERON:0003520 ! pelvis blood vessel is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter [Term] id: UBERON:0003476 name: respiratory system venous blood vessel def: "A vein that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius vein" EXACT [] synonym: "respiratory system vein" EXACT [] synonym: "vein of apparatus respiratorius" EXACT [] synonym: "vein of respiratory system" EXACT [] is_a: UBERON:0001638 ! vein [Term] id: UBERON:0003483 name: thymus lymphoid tissue def: "A portion of lymphoid tissue that is part of a thymus [Automatically generated definition]." [] synonym: "lymphatic tissue of thymus" EXACT [] synonym: "lymphatic tissue of thymus gland" EXACT [] synonym: "lymphocytic tissue of thymus" EXACT [] synonym: "lymphocytic tissue of thymus gland" EXACT [] synonym: "lymphoid tissue of thymus" EXACT [] synonym: "lymphoid tissue of thymus gland" EXACT [] synonym: "thymic lymphocytic tissue" EXACT [] synonym: "thymus gland lymphatic tissue" EXACT [] synonym: "thymus gland lymphocytic tissue" EXACT [] synonym: "thymus gland lymphoid tissue" EXACT [] synonym: "thymus lymphatic tissue" EXACT [] synonym: "thymus lymphocytic tissue" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001744 ! lymphoid tissue intersection_of: UBERON:0001744 ! lymphoid tissue intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0003484 name: eye sebaceous gland def: "A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland." [] synonym: "camera-type eye sebaceous gland" EXACT [] synonym: "sebaceous gland of camera-type eye" EXACT [] synonym: "sebaceous gland of vertebrate eye" EXACT [] synonym: "vertebrate eye sebaceous gland" EXACT [] is_a: UBERON:0003487 ! skin sebaceous gland is_a: UBERON:0003605 ! eye skin gland intersection_of: UBERON:0001821 ! sebaceous gland intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003485 name: vagina sebaceous gland def: "A sebaceous gland that is part of a vagina [Automatically generated definition]." [] synonym: "sebaceous gland of vagina" EXACT [] is_a: UBERON:0001821 ! sebaceous gland is_a: UBERON:0005398 ! female reproductive gland intersection_of: UBERON:0001821 ! sebaceous gland intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0003487 name: skin sebaceous gland def: "A holocrine gland of the dermis that secretes sebum into hair follicles." [] synonym: "cutaneous sebaceous gland" EXACT [] synonym: "sebaceous gland of skin" EXACT [] is_a: UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0011932 ! pilosebaceous unit [Term] id: UBERON:0003488 name: abdominal mammary gland def: "A lactiferous gland that is part of the abdominal region [Automatically generated definition]." [] synonym: "abdomen lactiferous gland" EXACT [] synonym: "abdomen lobe of breast" EXACT [] synonym: "abdomen lobe of mammary gland" EXACT [] synonym: "abdomen mammary gland" EXACT [] synonym: "lactiferous gland of abdomen" EXACT [] synonym: "lobe of breast of abdomen" EXACT [] synonym: "lobe of mammary gland of abdomen" EXACT [] synonym: "mammary gland of abdomen" EXACT [] is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005172 ! abdomen organ intersection_of: UBERON:0001911 ! mammary gland intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003489 name: respiratory system capillary endothelium def: "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius blood capillary endothelium" EXACT [] synonym: "apparatus respiratorius capillary endothelium" EXACT [] synonym: "apparatus respiratorius capillary vessel endothelium" EXACT [] synonym: "apparatus respiratorius endothelium of blood capillary" EXACT [] synonym: "apparatus respiratorius endothelium of capillary" EXACT [] synonym: "apparatus respiratorius endothelium of capillary vessel" EXACT [] synonym: "blood capillary endothelium of apparatus respiratorius" EXACT [] synonym: "blood capillary endothelium of respiratory system" EXACT [] synonym: "capillary endothelium of apparatus respiratorius" EXACT [] synonym: "capillary endothelium of respiratory system" EXACT [] synonym: "capillary vessel endothelium of apparatus respiratorius" EXACT [] synonym: "capillary vessel endothelium of respiratory system" EXACT [] synonym: "endothelium of blood capillary of apparatus respiratorius" EXACT [] synonym: "endothelium of blood capillary of respiratory system" EXACT [] synonym: "endothelium of capillary of apparatus respiratorius" EXACT [] synonym: "endothelium of capillary of respiratory system" EXACT [] synonym: "endothelium of capillary vessel of apparatus respiratorius" EXACT [] synonym: "endothelium of capillary vessel of respiratory system" EXACT [] synonym: "respiratory system blood capillary endothelium" EXACT [] synonym: "respiratory system capillary vessel endothelium" EXACT [] synonym: "respiratory system endothelium of blood capillary" EXACT [] synonym: "respiratory system endothelium of capillary" EXACT [] synonym: "respiratory system endothelium of capillary vessel" EXACT [] is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001915 ! endothelium of capillary intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003504 ! respiratory system blood vessel relationship: part_of UBERON:0003526 ! respiratory system capillary [Term] id: UBERON:0003494 name: respiratory system venule def: "A venule that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius venule" EXACT [] synonym: "venule of apparatus respiratorius" EXACT [] synonym: "venule of respiratory system" EXACT [] is_a: UBERON:0001979 ! venule is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001979 ! venule intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003495 name: respiratory system arteriole def: "An arteriole that is part of a respiratory system [Automatically generated definition]." [] is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001980 ! arteriole intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003469 ! respiratory system artery [Term] id: UBERON:0003496 name: head blood vessel def: "A blood vessel that is part of a head [Automatically generated definition]." [] synonym: "adult head blood vessel" EXACT [] synonym: "blood vessel of adult head" EXACT [] synonym: "blood vessel of head" EXACT [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0011362 ! cranial blood vasculature [Term] id: UBERON:0003497 name: abdomen blood vessel def: "A blood vessel that is part of an abdomen [Automatically generated definition]." [] synonym: "blood vessel of abdomen" EXACT [] is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003498 name: heart blood vessel def: "A blood vessel that is part of a heart [Automatically generated definition]." [] synonym: "blood vessel of heart" EXACT [] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0005985 ! coronary vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0003499 name: brain blood vessel def: "A blood vessel that is part of a brain [Automatically generated definition]." [] synonym: "blood vessel of brain" EXACT [] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0003500 name: corneal blood vessel def: "A blood vessel that is part of a cornea [Automatically generated definition]." [] synonym: "blood vessel of cornea" EXACT [] synonym: "cornea blood vessel" EXACT [] is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: UBERON:0003501 name: retina blood vessel def: "A blood vessel that is part of a retina [Automatically generated definition]." [] synonym: "blood vessel of inner layer of eyeball" EXACT [] synonym: "blood vessel of retina" EXACT [] synonym: "blood vessel of tunica interna of eyeball" EXACT [] synonym: "inner layer of eyeball blood vessel" EXACT [] synonym: "retinal blood vessel" EXACT [] synonym: "tunica interna of eyeball blood vessel" EXACT [] is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0004864 ! vasculature of retina [Term] id: UBERON:0003502 name: neck blood vessel def: "A blood vessel that is part of a neck [Automatically generated definition]." [] synonym: "blood vessel of neck" EXACT [] synonym: "blood vessel of neck (volume)" EXACT [] synonym: "neck (volume) blood vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003504 name: respiratory system blood vessel def: "A blood vessel that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius blood vessel" EXACT [] synonym: "blood vessel of apparatus respiratorius" EXACT [] synonym: "blood vessel of respiratory system" EXACT [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003505 name: trachea blood vessel def: "A blood vessel that is part of a trachea." [] synonym: "blood vessel of trachea" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003506 name: chest blood vessel def: "A blood vessel that is part of a chest [Automatically generated definition]." [] synonym: "anterior thoracic region blood vessel" EXACT [] synonym: "anterolateral part of thorax blood vessel" EXACT [] synonym: "blood vessel of anterior thoracic region" EXACT [] synonym: "blood vessel of anterolateral part of thorax" EXACT [] synonym: "blood vessel of chest" EXACT [] synonym: "blood vessel of front of thorax" EXACT [] synonym: "front of thorax blood vessel" EXACT [] is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0003509 name: arterial blood vessel def: "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0004572 ! arterial system relationship: part_of UBERON:0004572 ! arterial system [Term] id: UBERON:0003510 name: eyelid blood vessel def: "A blood vessel that is part of a eyelid [Automatically generated definition]." [] synonym: "blepharon blood vessel" EXACT [] synonym: "blood vessel of blepharon" EXACT [] synonym: "blood vessel of eyelid" EXACT [] is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0003511 name: iris blood vessel def: "A blood vessel that is part of a iris [Automatically generated definition]." [] synonym: "blood vessel of iris" EXACT [] is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0004118 ! vasculature of iris [Term] id: UBERON:0003512 name: lung blood vessel def: "A blood vessel that is part of a lung [Automatically generated definition]." [] synonym: "blood vessel of lung" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0003513 name: trunk blood vessel def: "A blood vessel that is part of a trunk [Automatically generated definition]." [] synonym: "blood vessel of torso" EXACT [] synonym: "blood vessel of trunk" EXACT [] synonym: "torso blood vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003517 name: kidney blood vessel def: "A blood vessel that is part of a kidney [Automatically generated definition]." [] synonym: "blood vessel of kidney" EXACT [] synonym: "renal blood vessel" EXACT [] is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0006544 ! kidney vasculature [Term] id: UBERON:0003520 name: pelvis blood vessel def: "A blood vessel that is part of a pelvis [Automatically generated definition]." [] synonym: "blood vessel of pelvis" EXACT [] is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002355 ! pelvis relationship: part_of UBERON:0002355 ! pelvis [Term] id: UBERON:0003526 name: respiratory system capillary def: "A capillary that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius blood capillary" EXACT [] synonym: "apparatus respiratorius capillary" EXACT [] synonym: "apparatus respiratorius capillary vessel" EXACT [] synonym: "blood capillary of apparatus respiratorius" EXACT [] synonym: "blood capillary of respiratory system" EXACT [] synonym: "capillary of apparatus respiratorius" EXACT [] synonym: "capillary of respiratory system" EXACT [] synonym: "capillary vessel of apparatus respiratorius" EXACT [] synonym: "capillary vessel of respiratory system" EXACT [] synonym: "respiratory system blood capillary" EXACT [] synonym: "respiratory system capillary vessel" EXACT [] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003527 name: kidney capillary def: "A capillary that is part of a kidney [Automatically generated definition]." [] synonym: "blood capillary of kidney" EXACT [] synonym: "capillary of kidney" EXACT [] synonym: "capillary vessel of kidney" EXACT [] synonym: "kidney blood capillary" EXACT [] synonym: "kidney capillary vessel" EXACT [] synonym: "renal capillary" EXACT [] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003517 ! kidney blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0006544 ! kidney vasculature [Term] id: UBERON:0003528 name: brain grey matter def: "A gray matter of neuraxis that is part of a brain [Automatically generated definition]." [] synonym: "brain gray matter" EXACT [] synonym: "brain gray matter of neuraxis" EXACT [] synonym: "brain grey substance" EXACT [] synonym: "gray matter of brain" EXACT [] synonym: "gray matter of neuraxis of brain" EXACT [] synonym: "grey matter of brain" EXACT [] synonym: "grey substance of brain" EXACT [] is_a: UBERON:0002020 ! gray matter of neuraxis intersection_of: UBERON:0002020 ! gray matter of neuraxis intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0003529 name: respiratory system lymphatic vessel endothelium def: "An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius endothelium of lymph vessel" EXACT [] synonym: "apparatus respiratorius lymph vessel endothelium" EXACT [] synonym: "apparatus respiratorius lymphatic vessel endothelium" EXACT [] synonym: "endothelium of lymph vessel of apparatus respiratorius" EXACT [] synonym: "endothelium of lymph vessel of respiratory system" EXACT [] synonym: "lymph vessel endothelium of apparatus respiratorius" EXACT [] synonym: "lymph vessel endothelium of respiratory system" EXACT [] synonym: "lymphatic vessel endothelium of apparatus respiratorius" EXACT [] synonym: "lymphatic vessel endothelium of respiratory system" EXACT [] synonym: "respiratory system endothelium of lymph vessel" EXACT [] synonym: "respiratory system lymph vessel endothelium" EXACT [] synonym: "respiratory system lymphatic vessel endothelium" EXACT [] is_a: UBERON:0002042 ! lymphatic vessel endothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0002042 ! lymphatic vessel endothelium intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel [Term] id: UBERON:0003546 name: distal convoluted tubule macula densa def: "A macula densa that is part of a distal convoluted tubule [Automatically generated definition]." [] is_a: UBERON:0002335 ! macula densa is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002335 ! macula densa intersection_of: part_of UBERON:0001292 ! distal convoluted tubule relationship: part_of UBERON:0001292 ! distal convoluted tubule relationship: part_of UBERON:0002335 ! macula densa [Term] id: UBERON:0003547 name: brain meninx def: "A meninx that is part of a brain [Automatically generated definition]." [] synonym: "brain meninges" EXACT [] synonym: "meninges of brain" EXACT [] synonym: "meninx of brain" EXACT [] is_a: UBERON:0002360 ! meninx intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0003548 name: forebrain meninges def: "A meninx that is part of a forebrain [Automatically generated definition]." [] synonym: "forebrain meninx" EXACT [] synonym: "meninges of forebrain" EXACT [] synonym: "meninx of forebrain" EXACT [] is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002360 ! meninx intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0003561 name: forebrain dura mater def: "A dura mater that is part of a forebrain." [] synonym: "dura mater of forebrain" EXACT [] synonym: "dura mater of neuraxis of forebrain" EXACT [] synonym: "forebrain dura mater of neuraxis" EXACT [] is_a: UBERON:0002092 ! brain dura mater is_a: UBERON:0003548 ! forebrain meninges intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: UBERON:0003562 name: midbrain dura mater def: "A dura mater that is part of a midbrain [Automatically generated definition]." [] synonym: "dura mater of midbrain" EXACT [] synonym: "dura mater of neuraxis of midbrain" EXACT [] synonym: "mesencephalon dura mater" RELATED [] synonym: "midbrain dura mater of neuraxis" EXACT [] is_a: UBERON:0002092 ! brain dura mater is_a: UBERON:0003288 ! meninx of midbrain intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain [Term] id: UBERON:0003563 name: telencephalon dura mater def: "A dura mater that is part of a telencephalon [Automatically generated definition]." [] synonym: "dura mater of neuraxis of telencephalon" EXACT [] synonym: "dura mater of telencephalon" EXACT [] synonym: "telencephalon dura mater of neuraxis" EXACT [] is_a: UBERON:0003289 ! meninx of telencephalon is_a: UBERON:0003561 ! forebrain dura mater intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0003564 name: diencephalon dura mater def: "A dura mater that is part of a diencephalon [Automatically generated definition]." [] synonym: "between brain dura mater" EXACT [] synonym: "between brain dura mater of neuraxis" EXACT [] synonym: "diencephalon dura mater of neuraxis" EXACT [] synonym: "dura mater of between brain" EXACT [] synonym: "dura mater of diencephalon" EXACT [] synonym: "dura mater of interbrain" EXACT [] synonym: "dura mater of mature diencephalon" EXACT [] synonym: "dura mater of neuraxis of between brain" EXACT [] synonym: "dura mater of neuraxis of diencephalon" EXACT [] synonym: "dura mater of neuraxis of interbrain" EXACT [] synonym: "dura mater of neuraxis of mature diencephalon" EXACT [] synonym: "interbrain dura mater" EXACT [] synonym: "interbrain dura mater of neuraxis" EXACT [] synonym: "mature diencephalon dura mater" EXACT [] synonym: "mature diencephalon dura mater of neuraxis" EXACT [] is_a: UBERON:0003290 ! meninx of diencephalon is_a: UBERON:0003561 ! forebrain dura mater intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0003565 name: hindbrain dura mater def: "A dura mater that is part of a hindbrain [Automatically generated definition]." [] synonym: "dura mater of hindbrain" EXACT [] synonym: "dura mater of neuraxis of hindbrain" EXACT [] synonym: "hindbrain dura mater of neuraxis" EXACT [] synonym: "rhombencephalon dura mater" RELATED [] is_a: UBERON:0002092 ! brain dura mater is_a: UBERON:0003291 ! meninx of hindbrain intersection_of: UBERON:0002363 ! dura mater intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0003566 name: head connective tissue def: "A portion of connective tissue that is part of a head [Automatically generated definition]." [] synonym: "adult head connective tissue" EXACT [] synonym: "adult head portion of connective tissue" EXACT [] synonym: "adult head textus connectivus" EXACT [] synonym: "connective tissue of adult head" EXACT [] synonym: "connective tissue of head" EXACT [] synonym: "head portion of connective tissue" EXACT [] synonym: "head textus connectivus" EXACT [] synonym: "portion of connective tissue of adult head" EXACT [] synonym: "portion of connective tissue of head" EXACT [] synonym: "textus connectivus of adult head" EXACT [] synonym: "textus connectivus of head" EXACT [] is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0003567 name: abdomen connective tissue def: "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." [] synonym: "abdomen portion of connective tissue" EXACT [] synonym: "abdomen textus connectivus" EXACT [] synonym: "connective tissue of abdomen" EXACT [] synonym: "portion of connective tissue of abdomen" EXACT [] synonym: "textus connectivus of abdomen" EXACT [] is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003568 name: neck connective tissue def: "A portion of connective tissue that is part of a neck [Automatically generated definition]." [] synonym: "connective tissue of neck" EXACT [] synonym: "connective tissue of neck (volume)" EXACT [] synonym: "neck (volume) connective tissue" EXACT [] synonym: "neck (volume) portion of connective tissue" EXACT [] synonym: "neck (volume) textus connectivus" EXACT [] synonym: "neck portion of connective tissue" EXACT [] synonym: "neck textus connectivus" EXACT [] synonym: "portion of connective tissue of neck" EXACT [] synonym: "portion of connective tissue of neck (volume)" EXACT [] synonym: "textus connectivus of neck" EXACT [] synonym: "textus connectivus of neck (volume)" EXACT [] is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003570 name: respiratory system connective tissue def: "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius connective tissue" EXACT [] synonym: "apparatus respiratorius portion of connective tissue" EXACT [] synonym: "apparatus respiratorius textus connectivus" EXACT [] synonym: "connective tissue of apparatus respiratorius" EXACT [] synonym: "connective tissue of respiratory system" EXACT [] synonym: "portion of connective tissue of apparatus respiratorius" EXACT [] synonym: "portion of connective tissue of respiratory system" EXACT [] synonym: "respiratory system portion of connective tissue" EXACT [] synonym: "respiratory system textus connectivus" EXACT [] synonym: "textus connectivus of apparatus respiratorius" EXACT [] synonym: "textus connectivus of respiratory system" EXACT [] is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003571 name: trachea connective tissue def: "A connective tissue that is part of a trachea." [] synonym: "connective tissue of trachea" EXACT [] synonym: "connective tissue of windpipe" EXACT [] synonym: "portion of connective tissue of trachea" EXACT [] synonym: "portion of connective tissue of windpipe" EXACT [] synonym: "textus connectivus of trachea" EXACT [] synonym: "textus connectivus of windpipe" EXACT [] synonym: "trachea portion of connective tissue" EXACT [] synonym: "trachea textus connectivus" EXACT [] synonym: "windpipe connective tissue" EXACT [] synonym: "windpipe portion of connective tissue" EXACT [] synonym: "windpipe textus connectivus" EXACT [] is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003572 name: chest connective tissue def: "A portion of connective tissue that is part of a chest [Automatically generated definition]." [] synonym: "anterior thoracic region connective tissue" EXACT [] synonym: "anterior thoracic region portion of connective tissue" EXACT [] synonym: "anterior thoracic region textus connectivus" EXACT [] synonym: "anterolateral part of thorax connective tissue" EXACT [] synonym: "anterolateral part of thorax portion of connective tissue" EXACT [] synonym: "anterolateral part of thorax textus connectivus" EXACT [] synonym: "chest portion of connective tissue" EXACT [] synonym: "chest textus connectivus" EXACT [] synonym: "connective tissue of anterior thoracic region" EXACT [] synonym: "connective tissue of anterolateral part of thorax" EXACT [] synonym: "connective tissue of chest" EXACT [] synonym: "connective tissue of front of thorax" EXACT [] synonym: "front of thorax connective tissue" EXACT [] synonym: "front of thorax portion of connective tissue" EXACT [] synonym: "front of thorax textus connectivus" EXACT [] synonym: "portion of connective tissue of anterior thoracic region" EXACT [] synonym: "portion of connective tissue of anterolateral part of thorax" EXACT [] synonym: "portion of connective tissue of chest" EXACT [] synonym: "portion of connective tissue of front of thorax" EXACT [] synonym: "textus connectivus of anterior thoracic region" EXACT [] synonym: "textus connectivus of anterolateral part of thorax" EXACT [] synonym: "textus connectivus of chest" EXACT [] synonym: "textus connectivus of front of thorax" EXACT [] is_a: UBERON:0003837 ! thoracic segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0003580 name: lower respiratory tract connective tissue def: "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." [] synonym: "connective tissue of lower respiratory tract" EXACT [] synonym: "lower respiratory tract portion of connective tissue" EXACT [] synonym: "lower respiratory tract textus connectivus" EXACT [] synonym: "portion of connective tissue of lower respiratory tract" EXACT [] synonym: "textus connectivus of lower respiratory tract" EXACT [] is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0003581 name: eyelid connective tissue def: "A portion of connective tissue that is part of a eyelid [Automatically generated definition]." [] synonym: "blepharon connective tissue" EXACT [] synonym: "blepharon portion of connective tissue" EXACT [] synonym: "blepharon textus connectivus" EXACT [] synonym: "connective tissue of blepharon" EXACT [] synonym: "connective tissue of eyelid" EXACT [] synonym: "eyelid portion of connective tissue" EXACT [] synonym: "eyelid textus connectivus" EXACT [] synonym: "portion of connective tissue of blepharon" EXACT [] synonym: "portion of connective tissue of eyelid" EXACT [] synonym: "textus connectivus of blepharon" EXACT [] synonym: "textus connectivus of eyelid" EXACT [] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0003582 name: nasopharynx connective tissue def: "A portion of connective tissue that is part of a nasopharynx [Automatically generated definition]." [] synonym: "connective tissue of nasal part of pharynx" EXACT [] synonym: "connective tissue of nasopharynx" EXACT [] synonym: "connective tissue of rhinopharynx" EXACT [] synonym: "nasal part of pharynx connective tissue" EXACT [] synonym: "nasal part of pharynx portion of connective tissue" EXACT [] synonym: "nasal part of pharynx textus connectivus" EXACT [] synonym: "nasopharynx portion of connective tissue" EXACT [] synonym: "nasopharynx textus connectivus" EXACT [] synonym: "portion of connective tissue of nasal part of pharynx" EXACT [] synonym: "portion of connective tissue of nasopharynx" EXACT [] synonym: "portion of connective tissue of rhinopharynx" EXACT [] synonym: "rhinopharynx connective tissue" EXACT [] synonym: "rhinopharynx portion of connective tissue" EXACT [] synonym: "rhinopharynx textus connectivus" EXACT [] synonym: "textus connectivus of nasal part of pharynx" EXACT [] synonym: "textus connectivus of nasopharynx" EXACT [] synonym: "textus connectivus of rhinopharynx" EXACT [] is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx [Term] id: UBERON:0003584 name: mammary gland connective tissue def: "the fibrous supportive tissue of the mammary gland." [] synonym: "connective tissue of lactiferous gland" EXACT [] synonym: "connective tissue of lobe of breast" EXACT [] synonym: "connective tissue of lobe of mammary gland" EXACT [] synonym: "connective tissue of mammary gland" EXACT [] synonym: "lactiferous gland connective tissue" EXACT [] synonym: "lactiferous gland portion of connective tissue" EXACT [] synonym: "lactiferous gland textus connectivus" EXACT [] synonym: "lobe of breast connective tissue" EXACT [] synonym: "lobe of breast portion of connective tissue" EXACT [] synonym: "lobe of breast textus connectivus" EXACT [] synonym: "lobe of mammary gland connective tissue" EXACT [] synonym: "lobe of mammary gland portion of connective tissue" EXACT [] synonym: "lobe of mammary gland textus connectivus" EXACT [] synonym: "mammary gland portion of connective tissue" EXACT [] synonym: "mammary gland textus connectivus" EXACT [] synonym: "portion of connective tissue of lactiferous gland" EXACT [] synonym: "portion of connective tissue of lobe of breast" EXACT [] synonym: "portion of connective tissue of lobe of mammary gland" EXACT [] synonym: "portion of connective tissue of mammary gland" EXACT [] synonym: "textus connectivus of lactiferous gland" EXACT [] synonym: "textus connectivus of lobe of breast" EXACT [] synonym: "textus connectivus of lobe of mammary gland" EXACT [] synonym: "textus connectivus of mammary gland" EXACT [] is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0003585 name: dermis connective tissue def: "A portion of connective tissue that is part of a dermis [Automatically generated definition]." [] synonym: "connective tissue of dermis" EXACT [] synonym: "dermis portion of connective tissue" EXACT [] synonym: "dermis textus connectivus" EXACT [] synonym: "portion of connective tissue of dermis" EXACT [] synonym: "textus connectivus of dermis" EXACT [] is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002067 ! dermis relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0002067 ! dermis [Term] id: UBERON:0003586 name: trunk connective tissue def: "A portion of connective tissue that is part of a trunk [Automatically generated definition]." [] synonym: "connective tissue of torso" EXACT [] synonym: "connective tissue of trunk" EXACT [] synonym: "portion of connective tissue of torso" EXACT [] synonym: "portion of connective tissue of trunk" EXACT [] synonym: "textus connectivus of torso" EXACT [] synonym: "textus connectivus of trunk" EXACT [] synonym: "torso connective tissue" EXACT [] synonym: "torso portion of connective tissue" EXACT [] synonym: "torso textus connectivus" EXACT [] synonym: "trunk portion of connective tissue" EXACT [] synonym: "trunk textus connectivus" EXACT [] is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003592 name: bronchus connective tissue def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi connective tissue" EXACT [] synonym: "bronchi portion of connective tissue" EXACT [] synonym: "bronchi textus connectivus" EXACT [] synonym: "bronchial trunk connective tissue" EXACT [] synonym: "bronchial trunk portion of connective tissue" EXACT [] synonym: "bronchial trunk textus connectivus" EXACT [] synonym: "bronchus portion of connective tissue" EXACT [] synonym: "bronchus textus connectivus" EXACT [] synonym: "connective tissue of bronchi" EXACT [] synonym: "connective tissue of bronchial trunk" EXACT [] synonym: "connective tissue of bronchus" EXACT [] synonym: "portion of connective tissue of bronchi" EXACT [] synonym: "portion of connective tissue of bronchial trunk" EXACT [] synonym: "portion of connective tissue of bronchus" EXACT [] synonym: "textus connectivus of bronchi" EXACT [] synonym: "textus connectivus of bronchial trunk" EXACT [] synonym: "textus connectivus of bronchus" EXACT [] is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0003594 name: pelvis connective tissue def: "A portion of connective tissue that is part of a pelvis [Automatically generated definition]." [] synonym: "connective tissue of pelvis" EXACT [] synonym: "pelvis portion of connective tissue" EXACT [] synonym: "pelvis textus connectivus" EXACT [] synonym: "portion of connective tissue of pelvis" EXACT [] synonym: "textus connectivus of pelvis" EXACT [] is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002355 ! pelvis relationship: part_of UBERON:0002355 ! pelvis [Term] id: UBERON:0003601 name: neck cartilage def: "A cartilage that is part of a neck [Automatically generated definition]." [] synonym: "cartilage of neck" EXACT [] synonym: "cartilage of neck (volume)" EXACT [] synonym: "neck (volume) cartilage" EXACT [] is_a: UBERON:0002418 ! cartilage tissue is_a: UBERON:0003568 ! neck connective tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003603 name: lower respiratory tract cartilage def: "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." [] synonym: "cartilage of lower respiratory tract" EXACT [] is_a: UBERON:0002418 ! cartilage tissue is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0003604 name: trachea cartilage def: "The cartilages of the trachea (or tracheal rings) vary from sixteen to twenty in number: each forms an imperfect ring, which occupies the anterior two-thirds or so of the circumference of the trachea, being deficient behind, where the tube is completed by fibrous tissue and unstriped muscular fibers." [] synonym: "cartilage of the trachea" RELATED [] synonym: "cartilage of trachea" EXACT [] synonym: "cartilage of windpipe" EXACT [] synonym: "cartilagines tracheales" RELATED [] synonym: "cartilaginous ring of trachea" EXACT [] synonym: "cartilaginous trachea cartilage" EXACT [] synonym: "cartilago trachealis" EXACT [] synonym: "ring of the trachea" RELATED [] synonym: "trachea ring" RELATED [] synonym: "tracheal cartilage" EXACT [] synonym: "tracheal ring" RELATED [] synonym: "windpipe cartilage" EXACT [] is_a: UBERON:0003571 ! trachea connective tissue is_a: UBERON:0003603 ! lower respiratory tract cartilage is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0007267 ! trachea pre-cartilage rings relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003605 name: eye skin gland def: "A skin gland that is part of a camera-type eye [Automatically generated definition]." [] synonym: "camera-type eye skin gland" EXACT [] synonym: "camera-type eye skin glands" EXACT [] synonym: "camera-type eye skin glands set" EXACT [] synonym: "skin gland of camera-type eye" EXACT [] synonym: "skin gland of vertebrate eye" EXACT [] synonym: "skin glands of camera-type eye" EXACT [] synonym: "skin glands of vertebrate eye" EXACT [] synonym: "skin glands set of camera-type eye" EXACT [] synonym: "skin glands set of vertebrate eye" EXACT [] synonym: "vertebrate eye skin gland" EXACT [] synonym: "vertebrate eye skin glands" EXACT [] synonym: "vertebrate eye skin glands set" EXACT [] is_a: UBERON:0002419 ! skin gland is_a: UBERON:0004859 ! eye gland intersection_of: UBERON:0002419 ! skin gland intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003609 name: aorta elastic tissue def: "the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." [] synonym: "adult aorta elastic connective tissue" EXACT [] synonym: "adult aorta elastic tissue" EXACT [] synonym: "adult aorta textus connectivus elasticus" EXACT [] synonym: "aorta elastic connective tissue" EXACT [] synonym: "aorta elastic lamina" EXACT [] synonym: "aorta elastic laminae" EXACT [] synonym: "aorta textus connectivus elasticus" EXACT [] synonym: "dorsal aorta elastic connective tissue" EXACT [] synonym: "dorsal aorta elastic tissue" EXACT [] synonym: "dorsal aorta textus connectivus elasticus" EXACT [] synonym: "elastic connective tissue of adult aorta" EXACT [] synonym: "elastic connective tissue of aorta" EXACT [] synonym: "elastic connective tissue of dorsal aorta" EXACT [] synonym: "elastic connective tissue of trunk of aortic tree" EXACT [] synonym: "elastic tissue of adult aorta" EXACT [] synonym: "elastic tissue of aorta" EXACT [] synonym: "elastic tissue of dorsal aorta" EXACT [] synonym: "elastic tissue of trunk of aortic tree" EXACT [] synonym: "textus connectivus elasticus of adult aorta" EXACT [] synonym: "textus connectivus elasticus of aorta" EXACT [] synonym: "textus connectivus elasticus of dorsal aorta" EXACT [] synonym: "textus connectivus elasticus of trunk of aortic tree" EXACT [] synonym: "trunk of aortic tree elastic connective tissue" EXACT [] synonym: "trunk of aortic tree elastic tissue" EXACT [] synonym: "trunk of aortic tree textus connectivus elasticus" EXACT [] is_a: UBERON:0003614 ! blood vessel elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0003610 name: heart elastic tissue def: "the type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." [] synonym: "cardiac elastic tissue" EXACT [] synonym: "elastic connective tissue of heart" EXACT [] synonym: "elastic tissue of heart" EXACT [] synonym: "heart elastic connective tissue" EXACT [] synonym: "heart textus connectivus elasticus" EXACT [] synonym: "textus connectivus elasticus of heart" EXACT [] is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0003611 name: respiratory system elastic tissue def: "An elastic tissue that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius elastic connective tissue" EXACT [] synonym: "apparatus respiratorius elastic tissue" EXACT [] synonym: "apparatus respiratorius textus connectivus elasticus" EXACT [] synonym: "elastic connective tissue of apparatus respiratorius" EXACT [] synonym: "elastic connective tissue of respiratory system" EXACT [] synonym: "elastic tissue of apparatus respiratorius" EXACT [] synonym: "elastic tissue of respiratory system" EXACT [] synonym: "respiratory system elastic connective tissue" EXACT [] synonym: "respiratory system textus connectivus elasticus" EXACT [] synonym: "textus connectivus elasticus of apparatus respiratorius" EXACT [] synonym: "textus connectivus elasticus of respiratory system" EXACT [] is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0004777 ! respiratory system submucosa [Term] id: UBERON:0003613 name: cardiovascular system elastic tissue def: "An elastic tissue that is part of a circulatory system [Automatically generated definition]." [] synonym: "cardiovascular system elastic connective tissue" EXACT [] synonym: "cardiovascular system textus connectivus elasticus" EXACT [] synonym: "circulatory system elastic connective tissue" EXACT [] synonym: "circulatory system elastic tissue" EXACT [] synonym: "circulatory system textus connectivus elasticus" EXACT [] synonym: "elastic connective tissue of cardiovascular system" EXACT [] synonym: "elastic connective tissue of circulatory system" EXACT [] synonym: "elastic tissue of cardiovascular system" EXACT [] synonym: "elastic tissue of circulatory system" EXACT [] synonym: "textus connectivus elasticus of cardiovascular system" EXACT [] synonym: "textus connectivus elasticus of circulatory system" EXACT [] is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0001009 ! circulatory system relationship: part_of UBERON:0001009 ! circulatory system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0003614 name: blood vessel elastic tissue def: "A tissue that is found in the tunica media of the vessels wall and allows vessels to stretch." [] synonym: "blood vessel elastic connective tissue" EXACT [] synonym: "blood vessel textus connectivus elasticus" EXACT [] synonym: "elastic connective tissue of blood vessel" EXACT [] synonym: "elastic tissue of blood vessel" EXACT [] synonym: "textus connectivus elasticus of blood vessel" EXACT [] synonym: "vascular elastic lamina" EXACT [] synonym: "vascular elastic laminae" EXACT [] synonym: "vascular elastic tissue" EXACT [] is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel [Term] id: UBERON:0003615 name: lung elastic tissue def: "Elastic tissue that is part of a lung [Automatically generated definition]." [] synonym: "elastic connective tissue of lung" EXACT [] synonym: "elastic tissue of lung" EXACT [] synonym: "lung elastic connective tissue" EXACT [] synonym: "lung textus connectivus elasticus" EXACT [] synonym: "pulmonary elastic fiber" NARROW [] synonym: "textus connectivus elasticus of lung" EXACT [] is_a: UBERON:0000114 ! lung connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0003616 name: bronchus elastic tissue def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi elastic connective tissue" EXACT [] synonym: "bronchi elastic tissue" EXACT [] synonym: "bronchi textus connectivus elasticus" EXACT [] synonym: "bronchial trunk elastic connective tissue" EXACT [] synonym: "bronchial trunk elastic tissue" EXACT [] synonym: "bronchial trunk textus connectivus elasticus" EXACT [] synonym: "bronchus elastic connective tissue" EXACT [] synonym: "bronchus textus connectivus elasticus" EXACT [] synonym: "elastic connective tissue of bronchi" EXACT [] synonym: "elastic connective tissue of bronchial trunk" EXACT [] synonym: "elastic connective tissue of bronchus" EXACT [] synonym: "elastic tissue of bronchi" EXACT [] synonym: "elastic tissue of bronchial trunk" EXACT [] synonym: "elastic tissue of bronchus" EXACT [] synonym: "textus connectivus elasticus of bronchi" EXACT [] synonym: "textus connectivus elasticus of bronchial trunk" EXACT [] synonym: "textus connectivus elasticus of bronchus" EXACT [] is_a: UBERON:0003592 ! bronchus connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0001957 ! submucosa of bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0003617 name: trachea elastic tissue def: "An elastic tissue that is part of a trachea [Automatically generated definition]." [] synonym: "cartilaginous trachea elastic connective tissue" EXACT [] synonym: "cartilaginous trachea elastic tissue" EXACT [] synonym: "cartilaginous trachea textus connectivus elasticus" EXACT [] synonym: "elastic connective tissue of cartilaginous trachea" EXACT [] synonym: "elastic connective tissue of vertebrate trachea" EXACT [] synonym: "elastic connective tissue of windpipe" EXACT [] synonym: "elastic tissue of cartilaginous trachea" EXACT [] synonym: "elastic tissue of vertebrate trachea" EXACT [] synonym: "elastic tissue of windpipe" EXACT [] synonym: "textus connectivus elasticus of cartilaginous trachea" EXACT [] synonym: "textus connectivus elasticus of vertebrate trachea" EXACT [] synonym: "textus connectivus elasticus of windpipe" EXACT [] synonym: "vertebrate trachea elastic connective tissue" EXACT [] synonym: "vertebrate trachea elastic tissue" EXACT [] synonym: "vertebrate trachea textus connectivus elasticus" EXACT [] synonym: "windpipe elastic connective tissue" EXACT [] synonym: "windpipe elastic tissue" EXACT [] synonym: "windpipe textus connectivus elasticus" EXACT [] is_a: UBERON:0003571 ! trachea connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0002202 ! submucosa of trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003619 name: aorta tunica intima def: "the innermost layer of the aorta, containing the endothelium and an inner elastic membrane." [] synonym: "adult aorta tunica intima" EXACT [] synonym: "dorsal aorta tunica intima" EXACT [] synonym: "trunk of aortic tree tunica intima" EXACT [] synonym: "tunica intima of adult aorta" EXACT [] synonym: "tunica intima of aorta" EXACT [] synonym: "tunica intima of dorsal aorta" EXACT [] synonym: "tunica intima of trunk of aortic tree" EXACT [] is_a: UBERON:0002523 ! tunica intima intersection_of: UBERON:0002523 ! tunica intima intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0004663 ! aorta wall [Term] id: UBERON:0003643 name: respiratory system arterial blood vessel def: "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." [] is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003509 ! arterial blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003644 name: kidney arterial blood vessel def: "An arterial blood vessel that is part of a kidney [Automatically generated definition]." [] is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:0003517 ! kidney blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0003672 name: dentition def: "A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl." [] synonym: "collection of teeth" RELATED [] synonym: "dentes" EXACT [] synonym: "set of teeth" EXACT [] synonym: "teeth" EXACT [] synonym: "teeth" RELATED [] synonym: "teeth set" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0010323 ! cranial skeletal system [Term] id: UBERON:0003685 name: cranial suture def: "Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture." [] synonym: "cranium suture" EXACT [] synonym: "sutura" EXACT [] synonym: "suture" EXACT [] synonym: "suture joint of skull" EXACT [] synonym: "suture of cranium" EXACT [] is_a: UBERON:0009198 ! craniofacial suture intersection_of: UBERON:0002209 ! fibrous joint intersection_of: part_of UBERON:0003128 ! cranium relationship: part_of UBERON:0003128 ! cranium [Term] id: UBERON:0003688 name: omentum def: "A fold of peritoneum originating at the stomach and supporting the viscera." [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001178 ! visceral peritoneum [Term] id: UBERON:0003697 name: abdominal wall def: "The abdominal wall represents the boundaries of the abdominal cavity. The abdominal wall is split into the posterior (back), lateral (sides) and anterior (front) walls. There is a common set of layers covering and forming all the walls: the deepest being the extraperitoneal fat, the parietal peritoneum, and a layer of fascia which has different names over where it covers (eg transversalis, psoas fascia). Superficial to these, but not present in the posterior wall are the three layers of muscle, the transversus abdominis (transverse abdominal muscle), the internal (obliquus internus) and the external oblique (obliquus externus)." [] synonym: "layers of the abdominal wall" RELATED [] synonym: "paries abdominalis" EXACT [] synonym: "paries abdominalis" RELATED [] synonym: "wall of abdomen" EXACT [] synonym: "wall of abdomen proper" EXACT [] is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003704 name: intrahepatic bile duct def: "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." [] synonym: "bile duct intrahepatic part" EXACT [] synonym: "intrahepatic biliary system" RELATED [] is_a: UBERON:0002394 ! bile duct intersection_of: UBERON:0002394 ! bile duct intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver [Term] id: UBERON:0003714 name: neural tissue def: "Portion of tissue which consists of neurons, neuroglia and vasculature. Examples: Neural tissue of brain, neural tissue of peripheral ganglion, neural tissue of nerve[FMA]." [] synonym: "nerve tissue" EXACT [] synonym: "nervous tissue" EXACT [] synonym: "portion of neural tissue" EXACT [] is_a: UBERON:0000479 ! tissue relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0003729 name: mouth mucosa def: "A mucous membrane that lines the mouth." [] synonym: "buccal mucosa" RELATED [] synonym: "mouth mucosa" EXACT [] synonym: "mouth mucous membrane" EXACT [] synonym: "mouth organ mucosa" EXACT [] synonym: "mucosa of mouth" EXACT [] synonym: "mucosal lining of mouth" RELATED [] synonym: "mucous membrane of mouth" EXACT [] synonym: "oral mucosa" RELATED [] synonym: "oral mucous membrane" EXACT [] synonym: "oral part of viscerocranial mucosa" EXACT [] synonym: "tunica mucosa oris" EXACT [] synonym: "tunica mucosa oris" RELATED [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000165 ! mouth relationship: part_of UBERON:0000165 ! mouth [Term] id: UBERON:0003820 name: prostate bud def: "A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." [] synonym: "prostate ductal progenitor" EXACT [] synonym: "prostatic bud" EXACT [] is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0009847 ! prostate field relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0003824 name: nerve of thoracic segment def: "A nerve that is part of a thorax [Automatically generated definition]." [] synonym: "nerve of thorax" EXACT [] synonym: "thoracic segment nerve" EXACT [] synonym: "thorax nerve" EXACT [] synonym: "upper body nerve" RELATED [] is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003825 name: nerve of abdominal segment def: "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." [] synonym: "abdominal segment nerve" EXACT [] is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003827 name: thoracic segment bone def: "A bone that is part of a thorax [Automatically generated definition]." [] synonym: "bone of thorax" EXACT [] synonym: "bone organ of thorax" EXACT [] synonym: "thorax bone" EXACT [] synonym: "thorax bone organ" EXACT [] synonym: "upper body bone" RELATED [] is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003828 name: abdominal segment bone def: "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." [] synonym: "abdominal segment of trunk bone" EXACT [] synonym: "abdominal segment of trunk bone organ" EXACT [] synonym: "bone of abdominal segment of trunk" EXACT [] synonym: "bone organ of abdominal segment of trunk" EXACT [] is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005173 ! abdominal segment organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003829 name: urethra muscle def: "A muscle organ that is part of a urethra [Automatically generated definition]." [] synonym: "muscle layer of urethra" RELATED [] synonym: "muscle organ of urethra" EXACT [] synonym: "muscular coat of urethra" EXACT [] synonym: "muscular layer of urethra" EXACT [] synonym: "urethra muscle organ" EXACT [] synonym: "urethral muscle layer" RELATED [] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: UBERON:0003830 name: thoracic segment muscle def: "A muscle organ that is part of a thorax [Automatically generated definition]." [] synonym: "muscle organ of thorax" EXACT [] synonym: "thorax muscle organ" EXACT [] synonym: "upper body muscle" RELATED [] is_a: UBERON:0001774 ! muscle of trunk is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0004464 ! musculature of thorax [Term] id: UBERON:0003831 name: respiratory system muscle def: "A muscle organ that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius muscle organ" EXACT [] synonym: "muscle organ of apparatus respiratorius" EXACT [] synonym: "muscle organ of respiratory system" EXACT [] synonym: "respiratory system muscle organ" EXACT [] is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003832 name: esophagus muscle def: "A muscle organ that is part of a esophagus [Automatically generated definition]." [] synonym: "esophageal muscle" EXACT [] synonym: "esophagus muscle organ" EXACT [] synonym: "gullet muscle organ" EXACT [] synonym: "muscle organ of esophagus" EXACT [] synonym: "muscle organ of gullet" EXACT [] synonym: "muscle organ of oesophagus" EXACT [] synonym: "oesophagus muscle organ" EXACT [] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0013765 ! digestive system organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0003833 name: abdominal segment muscle def: "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." [] synonym: "abdominal segment of trunk muscle organ" EXACT [] synonym: "muscle organ of abdominal segment of trunk" EXACT [] is_a: UBERON:0001774 ! muscle of trunk is_a: UBERON:0005173 ! abdominal segment organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003834 name: thoracic segment blood vessel def: "A blood vessel that is part of a thorax [Automatically generated definition]." [] synonym: "blood vessel of thorax" EXACT [] synonym: "thorax blood vessel" EXACT [] synonym: "upper body blood vessel" RELATED [] is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003835 name: abdominal segment blood vessel def: "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." [] synonym: "abdominal segment of trunk blood vessel" EXACT [] synonym: "blood vessel of abdominal segment of trunk" EXACT [] is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003837 name: thoracic segment connective tissue def: "A portion of connective tissue that is part of a thorax [Automatically generated definition]." [] synonym: "connective tissue of thorax" EXACT [] synonym: "portion of connective tissue of thorax" EXACT [] synonym: "textus connectivus of thorax" EXACT [] synonym: "thorax connective tissue" EXACT [] synonym: "thorax portion of connective tissue" EXACT [] synonym: "thorax textus connectivus" EXACT [] synonym: "upper body connective tissue" RELATED [] is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003838 name: abdominal segment connective tissue def: "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." [] synonym: "abdominal segment of trunk connective tissue" EXACT [] synonym: "abdominal segment of trunk portion of connective tissue" EXACT [] synonym: "abdominal segment of trunk textus connectivus" EXACT [] synonym: "connective tissue of abdominal segment of trunk" EXACT [] synonym: "portion of connective tissue of abdominal segment of trunk" EXACT [] synonym: "textus connectivus of abdominal segment of trunk" EXACT [] is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003843 name: dental epithelium def: "Epithelium that is part of a developing tooth or dental organ." [] synonym: "dental epithelia" EXACT [] synonym: "dental epithelium" EXACT [] synonym: "odontogenic epithelium" EXACT [] synonym: "reduced enamel epithelium" RELATED [] synonym: "tooth epithelium" EXACT [] is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0005176 ! tooth enamel organ relationship: develops_from UBERON:0004362 ! pharyngeal arch 1 relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: UBERON:0003846 name: thymus epithelium def: "the supporting framework of the thymus." [] synonym: "epithelial tissue of thymus" EXACT [] synonym: "epithelial tissue of thymus gland" EXACT [] synonym: "epithelium of thymus" EXACT [] synonym: "epithelium of thymus gland" EXACT [] synonym: "thymic epithelial tissue" EXACT [] synonym: "thymic epithelium" EXACT [] synonym: "thymus epithelial tissue" EXACT [] synonym: "thymus gland epithelial tissue" EXACT [] synonym: "thymus gland epithelium" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0003849 name: mesencephalic neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." [] synonym: "mesencephalic neural crest" EXACT [] synonym: "neural crest midbrain" EXACT [] is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 ! cranial neural crest [Term] id: UBERON:0003852 name: rhombencephalon neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." [] synonym: "neural crest hindbrain" EXACT [] synonym: "rhombencephalic neural crest" EXACT [] is_a: UBERON:0002342 ! neural crest [Term] id: UBERON:0003855 name: gonad mesenchyme def: "Mesenchyme that is part of a gonad [Automatically generated definition]." [] synonym: "gonada mesenchyme" EXACT [] synonym: "mesenchyme of gonad" EXACT [] synonym: "mesenchyme of gonada" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000991 ! gonad relationship: part_of UBERON:0000991 ! gonad [Term] id: UBERON:0003856 name: odontogenic mesenchyme def: "Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla." [] synonym: "dental mesenchyme" EXACT [] synonym: "dental organ mesenchyme" EXACT [] synonym: "enamel organ mesenchyme" EXACT [] synonym: "tooth enamel organ mesenchyme" EXACT [] synonym: "tooth mesenchyme" EXACT [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0005176 ! tooth enamel organ relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: UBERON:0003869 name: presumptive ganglion def: "A presumptive structure that has_potential_to_develop_into a ganglion." [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0003885 name: mesometrium def: "A mesentery that is part of a uterus [Automatically generated definition]." [] synonym: "mesentery of uterus" RELATED [] is_a: UBERON:0001297 ! serosa of uterus is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000459 ! uterine wall relationship: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0012332 ! broad ligament of uterus [Term] id: UBERON:0003886 name: body cavity precursor def: "An anatomical cavity that has_potential_to_develop_into a coelemic cavity lumen." [] is_a: UBERON:0000464 ! anatomical space [Term] id: UBERON:0003887 name: intraembryonic coelom def: "In the development of the human embryo the intraembryonic coelom (or somatic coelom) is a portion of the conceptus forming in the mesoderm. During the second week of development, the lateral mesoderm splits into a dorsal somatic mesoderm (somatopleure) and a ventral splanchnic mesoderm (splanchnopleure). The resulting cavity between the somatopleure and splanchnopleure is called the intraembryonic coelom. This space will give rise to the thoracic and abdominal cavities. It briefly has a connection with the extraembryonic coelom[WP]." [] synonym: "somatic coelom" EXACT [] is_a: UBERON:0003886 ! body cavity precursor relationship: develops_from UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0003889 name: fallopian tube def: "Two very fine tubes lined with ciliated epithelia, leading from the ovaries of female mammals into the uterus, via the utero-tubal junction[WP]. Embryos have two pairs of ducts to let gametes out of the body; one pair (the Mullerian ducts) develops in females into the Fallopian tubes, uterus and vagina, while the other pair (the Wolffian ducts) develops in males into the epididymis and vas deferens." [] synonym: "fallopian tubes" RELATED [] synonym: "female paramesonephric duct" RELATED [] synonym: "mammalian oviduct" EXACT [] synonym: "salpinges" BROAD [] synonym: "salpinx" BROAD [] synonym: "tuba uterina" RELATED [] synonym: "uterine tube (sensu Mammalia)" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000025 ! tube intersection_of: develops_from UBERON:0003890 ! Mullerian duct intersection_of: part_of UBERON:0000993 ! oviduct relationship: develops_from UBERON:0003890 ! Mullerian duct relationship: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0002355 ! pelvis [Term] id: UBERON:0003890 name: Mullerian duct def: "paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM]." [] synonym: "ductus paramesonephricus" EXACT [] synonym: "early paramesonephric duct" NARROW [] synonym: "Muellerian duct" EXACT [] synonym: "Mllerian duct" EXACT [] synonym: "paramesonephric duct" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0003891 name: stroma def: "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0003893 name: capsule def: "a cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP]." [] is_a: UBERON:0000158 ! membranous layer [Term] id: UBERON:0003894 name: liver primordium def: "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." [] synonym: "embryological hepatic plate" EXACT [] synonym: "hepatic plate" RELATED [] synonym: "liver bud" RELATED [] synonym: "liver endoderm" RELATED [] synonym: "primordium of the liver" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007497 ! developing epithelial placode is_a: UBERON:0009497 ! epithelium of foregut-midgut junction relationship: develops_from UBERON:0001041 ! foregut relationship: part_of UBERON:0009550 ! endoderm of foregut-midgut junction [Term] id: UBERON:0003898 name: skeletal muscle tissue of trunk def: "A portion of skeletal muscle tissue in the trunk." [] synonym: "skeletal muscle of torso" EXACT [] synonym: "skeletal muscle tissue of torso" EXACT [] synonym: "skeletal muscle tissue of trunk" EXACT [] synonym: "torso skeletal muscle" EXACT [] synonym: "torso skeletal muscle tissue" EXACT [] synonym: "trunk skeletal muscle" EXACT [] synonym: "trunk skeletal muscle tissue" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0004479 ! musculature of trunk relationship: part_of UBERON:0013700 ! axial musculature [Term] id: UBERON:0003909 name: sinusoid def: "small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." [] synonym: "endothelium of irregular blood filled space" RELATED [] synonym: "sinusoidal blood vessel" EXACT [] synonym: "sinusoidal blood vessel endothelium" EXACT [] synonym: "sinusoidal capillary" RELATED [] synonym: "sinusoidal endothelium" RELATED [] is_a: UBERON:2005260 ! fenestrated capillary [Term] id: UBERON:0003910 name: splenic sinusoid def: "wide vessels in the spleen that drain into trabecular veins[WP]." [] synonym: "sinusoid of red pulp of spleen" RELATED [] synonym: "sinusoidal blood vessel of spleen" EXACT [] is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0003909 ! sinusoid intersection_of: UBERON:0003909 ! sinusoid intersection_of: part_of UBERON:0001250 ! red pulp of spleen relationship: part_of UBERON:0001250 ! red pulp of spleen [Term] id: UBERON:0003911 name: choroid plexus epithelium def: "An epithelium that is part of a choroid plexus [Automatically generated definition]." [] synonym: "chorioid plexus of cerebral hemisphere epithelial tissue" EXACT [] synonym: "chorioid plexus of cerebral hemisphere epithelium" EXACT [] synonym: "choroid plexus epithelial tissue" EXACT [] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [] synonym: "epithelial tissue of choroid plexus" EXACT [] synonym: "epithelium of chorioid plexus of cerebral hemisphere" EXACT [] synonym: "epithelium of choroid plexus" EXACT [] is_a: UBERON:0005357 ! brain ependyma intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus [Term] id: UBERON:0003913 name: tooth-like structure def: "hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [] synonym: "tooth-like organ" EXACT [] is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0003914 name: epithelial tube def: "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [] synonym: "epithelial or endothelial tube" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0003915 name: endothelial tube def: "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." [] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003914 ! epithelial tube [Term] id: UBERON:0003918 name: kidney mesenchyme def: "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." [] synonym: "mesenchyme of kidney" EXACT [] is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0003920 name: venous blood vessel def: "a blood vessel that carries blood from the capillaries toward the heart" [] synonym: "segment of venous tree organ" EXACT [] synonym: "venous tree organ segment" EXACT [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0004582 ! venous system relationship: part_of UBERON:0004582 ! venous system [Term] id: UBERON:0003921 name: pancreas primordium def: "embryonic structure that develops into pancreatic bud." [] synonym: "pancreatic anlage" RELATED [] synonym: "pancreatic endoderm" RELATED [] synonym: "pancreatic primordium" EXACT [] synonym: "primordial pancreas" RELATED [] is_a: UBERON:0001048 ! primordium relationship: develops_from UBERON:0000925 ! endoderm relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0007026 ! primitive gut [Term] id: UBERON:0003922 name: pancreatic bud def: "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. In humans, an embryonic structure that is an outgrowth of the duodenum during embryogenesis - joins together to form the adult pancreas[WP]." [] synonym: "pancreatic anlage" RELATED [] synonym: "pancreatic buds" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 ! epithelial sac relationship: develops_from UBERON:0001041 ! foregut relationship: develops_from UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0002114 ! duodenum relationship: develops_from UBERON:0009497 ! epithelium of foregut-midgut junction relationship: part_of UBERON:0003921 ! pancreas primordium [Term] id: UBERON:0003923 name: dorsal pancreatic bud def: "pancreatic bud that gives rise to the accessory pancreatic duct." [] synonym: "dorsal pancreas anlage" RELATED [] synonym: "dorsal pancreatic anlage" RELATED [] synonym: "pancreas dorsal primordium duct bud" EXACT [] synonym: "pancreas primordium dorsal bud" EXACT [] synonym: "posterior pancreatic anlage" RELATED [] synonym: "posterior pancreatic bud" RELATED [] is_a: UBERON:0003922 ! pancreatic bud relationship: develops_from UBERON:0001045 ! midgut relationship: part_of UBERON:0010375 ! pancreas dorsal primordium [Term] id: UBERON:0003924 name: ventral pancreatic bud def: "pancreatic bud that gives rise to the major pancreatic duct." [] synonym: "anterior pancreatic anlage" RELATED [] synonym: "anterior pancreatic bud" RELATED [] synonym: "pancreas primordium ventral bud" EXACT [] synonym: "pancreas ventral primordium duct bud" EXACT [] synonym: "ventral pancreas anlage" RELATED [] synonym: "ventral pancreatic anlage" RELATED [] is_a: UBERON:0003922 ! pancreatic bud relationship: develops_from UBERON:0008835 ! hepatic diverticulum relationship: part_of UBERON:0010376 ! pancreas ventral primordium [Term] id: UBERON:0003928 name: digestive system duct def: "A duct that is part of a digestive system [Automatically generated definition]." [] synonym: "duct of digestive system" EXACT [] synonym: "duct of gastrointestinal system" EXACT [] synonym: "gastrointestinal system duct" EXACT [] is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0003929 name: gut epithelium def: "An epithelium that is part of a digestive tract [Automatically generated definition]." [] synonym: "digestive tract epithelial tissue" EXACT [] synonym: "digestive tract epithelium" EXACT [] synonym: "epithelial tissue of digestive tract" EXACT [] synonym: "epithelial tissue of gut" EXACT [] synonym: "epithelial tissue of lower gastrointestinal tract" EXACT [] synonym: "epithelium of digestive tract" EXACT [] synonym: "epithelium of gut" EXACT [] synonym: "epithelium of lower gastrointestinal tract" EXACT [] synonym: "gut epithelial tissue" EXACT [] synonym: "lower gastrointestinal tract epithelial tissue" EXACT [] synonym: "lower gastrointestinal tract epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0003932 name: cartilage element of chondrocranium def: "A cartilage element of chondrocranium. Example: neurocranial trabecula." [] synonym: "cartilage of chondrocranium" EXACT [] synonym: "cartilaginous element of chondrocranium" EXACT [] synonym: "chondrocranium cartilage" EXACT [] synonym: "neurocranium cartilage" EXACT [] is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0002241 ! chondrocranium relationship: part_of UBERON:0002241 ! chondrocranium [Term] id: UBERON:0003933 name: cranial cartilage def: "A cartilage element that is part of the cranial skeleton." [] synonym: "cartilage of cranium" EXACT [] synonym: "cranium cartilage" EXACT [] is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0010323 ! cranial skeletal system relationship: part_of UBERON:0010323 ! cranial skeletal system [Term] id: UBERON:0003937 name: sex gland def: "any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [] synonym: "genitalia gland" EXACT [] synonym: "gland of genitalia" EXACT [] synonym: "gland of reproductive system" EXACT [] synonym: "reproductive gland" EXACT [] synonym: "reproductive system gland" EXACT [] is_a: UBERON:0002530 ! gland is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000990 ! reproductive system relationship: part_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0003942 name: somatic sensory system def: "the neural tissue involved in the transmission of sensory signals" [] is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: part_of UBERON:0000012 ! somatic nervous system relationship: part_of UBERON:0000012 ! somatic nervous system [Term] id: UBERON:0003947 name: brain ventricle/choroid plexus def: "the brain ventricles or their associated choroid plexuses" [] is_a: UBERON:0004121 ! ectoderm-derived structure union_of: UBERON:0001886 ! choroid plexus union_of: UBERON:0004086 ! brain ventricle relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0003956 name: aqueous drainage system def: "the structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins" [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001768 ! uvea [Term] id: UBERON:0003970 name: placental labyrinth vasculature def: "blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [] synonym: "placenta vascular network" EXACT [] synonym: "placenta vasculature" EXACT [] synonym: "vascular network of placenta" EXACT [] synonym: "vasculature of placenta" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta [Term] id: UBERON:0003975 name: internal female genitalia def: "the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." [] synonym: "female internal genitalia" EXACT [] synonym: "internal female genital organ" EXACT [] synonym: "internal genitalia of female reproductive system" EXACT [] synonym: "organa genitalia feminina interna" RELATED [] is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: UBERON:0004001 name: olfactory bulb layer def: "." [] synonym: "cytoarchitectural part of olfactory bulb" EXACT [] is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002264 ! olfactory bulb [Term] id: UBERON:0004041 name: spleen primary B follicle def: "the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [] synonym: "primary spleen B cell follicle" EXACT [] is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004042 name: spleen secondary B follicle def: "the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" [] synonym: "secondary spleen B cell follicle" EXACT [] synonym: "splenic secondary B cell follicle" EXACT [] is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0001745 ! secondary nodular lymphoid tissue intersection_of: UBERON:0001745 ! secondary nodular lymphoid tissue intersection_of: part_of UBERON:0002106 ! spleen relationship: develops_from UBERON:0004041 ! spleen primary B follicle relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004043 name: semicircular canal ampulla def: "the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [] synonym: "ampullae osseae" RELATED [] synonym: "membraneous ampulla of the semicircular duct" RELATED [] synonym: "semicircular duct ampulla" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001840 ! semicircular canal relationship: part_of UBERON:0001856 ! semicircular duct [Term] id: UBERON:0004053 name: external male genitalia def: "the external masculine genital organs, including the penis and scrotum" [] synonym: "external male genital organ" EXACT [] synonym: "male external genitalia" EXACT [] synonym: "organa genitalia masculina externa" RELATED [] is_a: UBERON:0003135 ! male reproductive organ is_a: UBERON:0004176 ! external genitalia intersection_of: UBERON:0004176 ! external genitalia intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0004054 name: internal male genitalia def: "the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [] synonym: "internal male genital organ" EXACT [] synonym: "male internal genitalia" EXACT [] synonym: "organa genitalia masculina interna" RELATED [] is_a: UBERON:0003135 ! male reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0004061 name: neural tube mantle layer def: "the layer of glia and differentiating neurons that will form the gray matter of the spinal cord; this lies between the ventricular and marginal layers and includes the basal and alar plates" [] synonym: "neural tube intermediate zone" EXACT [] is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0004066 name: frontonasal prominence def: "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." [] synonym: "embryonic frontonasal prominence" EXACT [] synonym: "forebrain prominence" RELATED [] synonym: "frontonasal mass" RELATED [] synonym: "frontonasal process" RELATED [] synonym: "prominentia frontonasalis" RELATED [] is_a: UBERON:0009292 ! embryonic nasal process [Term] id: UBERON:0004068 name: medial nasal prominence def: "the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" [] synonym: "medial nasal process" EXACT [] synonym: "medial nasal swelling" RELATED [] synonym: "medial-nasal process" EXACT [] synonym: "nasomedial prominence" RELATED [] synonym: "prominentia nasalis medialis" EXACT [] is_a: UBERON:0009292 ! embryonic nasal process relationship: develops_from UBERON:0004066 ! frontonasal prominence relationship: part_of UBERON:0004066 ! frontonasal prominence [Term] id: UBERON:0004086 name: brain ventricle def: "one of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid" [] synonym: "cerebral ventricle" EXACT [] synonym: "region of ventricular system of brain" EXACT [] is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005358 ! ventricle of nervous system relationship: part_of UBERON:0005282 ! ventricular system of brain [Term] id: UBERON:0004088 name: ocular region def: "." [] synonym: "content of orbital part of eye" EXACT [] synonym: "eye region" EXACT [] synonym: "orbital content" RELATED [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0004089 name: midface def: "the middle of the face including the nose and its associated bony structures[MW]." [] synonym: "lower face" RELATED [] synonym: "midface/lower face" RELATED [] synonym: "snout" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0004111 name: anatomical conduit def: "any opening in the body." [] synonym: "foramen" NARROW [] synonym: "foramina" NARROW [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0004117 name: pharyngeal pouch def: "embryonic structure that forms on the endodermal side between the pharyngeal arches, and pharyngeal grooves (or clefts) form the lateral ectodermal surface of the neck region to separate the arches. The pouches line up with the clefts, and these thin segments become gills in fish[WP]. Outpocketings of pharyngeal endoderm that interdigitate with the neural crest derived pharyngeal arches. The pouches later fuse with the surface ectoderm to form the gill slits[ZFA]." [] synonym: "branchial pouch" EXACT [] synonym: "pharyngeal pouches" RELATED [] synonym: "visceral pouch" EXACT [] synonym: "visceral pouches" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0008814 ! pharyngeal system [Term] id: UBERON:0004118 name: vasculature of iris def: "A vasculature that is part of a iris [Automatically generated definition]." [] synonym: "iris blood vessels" EXACT [] synonym: "iris vascular network" EXACT [] synonym: "iris vasculature" EXACT [] synonym: "vascular network of iris" EXACT [] is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0004119 name: endoderm-derived structure def: "An anatomical structure that develops (entirely or partially) from the endoderm." [] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0000925 ! endoderm [Term] id: UBERON:0004120 name: mesoderm-derived structure def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0004121 name: ectoderm-derived structure def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0000924 ! ectoderm [Term] id: UBERON:0004122 name: genitourinary system def: "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." [] synonym: "genitourinary tract" RELATED [] synonym: "GU tract" RELATED [] synonym: "UG tract" RELATED [] synonym: "urogenital system" EXACT [] synonym: "urogenital tract" RELATED [] synonym: "Urogenitalsystem" RELATED [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0003064 ! intermediate mesoderm [Term] id: UBERON:0004123 name: myocardial layer def: "An organ component layer that is part of a myocardium." [] synonym: "layer of myocardium" EXACT [] synonym: "myocardium layer" EXACT [] is_a: UBERON:0005983 ! heart layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: part_of UBERON:0002349 ! myocardium relationship: part_of UBERON:0002349 ! myocardium [Term] id: UBERON:0004128 name: optic vesicle def: "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." [] synonym: "evagination" RELATED [] synonym: "ocular vesicle" RELATED [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0003071 ! eye primordium relationship: part_of UBERON:0010312 ! immature eye [Term] id: UBERON:0004129 name: growth plate cartilage def: "cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [] synonym: "growth plate" RELATED [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0004134 name: proximal tubule def: "In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO]." [] synonym: "kidney proximal tubule" EXACT [] synonym: "proximal kidney tubule" EXACT [] synonym: "renal proximal tubule" EXACT [] is_a: UBERON:0006853 ! renal cortex tubule relationship: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001231 ! nephron tubule [Term] id: UBERON:0004135 name: distal tubule def: "The distal tubule is a nephron tubule that consists of the convoluted and straight distal tubule segments" [] synonym: "kidney distal tubule" EXACT [] synonym: "renal distal tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0004136 name: intermediate tubule def: "The intermediate tubule is a nephron tubule that lies between the proximal and distal tubules" [] synonym: "renal intermediate tubule" EXACT [] synonym: "tubulus attenuatus" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule relationship: part_of UBERON:0001288 ! loop of Henle [Term] id: UBERON:0004139 name: cardiogenic plate def: "The first recognizable structure derived from the heart field" [] synonym: "cardiogenic crescent" RELATED [] synonym: "heart rudiment" RELATED [] synonym: "myocardial plate" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003084 ! heart primordium relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0004140 name: primary heart field def: "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [] synonym: "first heart field" EXACT [] synonym: "heart field" RELATED [] synonym: "primary heart field" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0004141 name: heart tube def: "An epithelial tube that will give rise to the mature heart." [] synonym: "embryonic heart tube" EXACT [] synonym: "endocardial heart tube" EXACT [] synonym: "endocardial tube" EXACT [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0004142 name: outflow tract septum def: "The outflow tract septum is a partition in the outflow tract" [] is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004145 name: outflow tract def: "The outflow tract is the portion of the heart through which blood flows into the arteries" [] synonym: "cardiac outflow tract" EXACT [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0004146 name: His-Purkinje system def: "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles" [] synonym: "distal conduction system" EXACT [] synonym: "His-Purkinji network" EXACT [] synonym: "HPS" EXACT [] is_a: UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0004151 name: cardiac chamber def: "A cardiac chamber surrounds an enclosed cavity within the heart" [] synonym: "chamber of heart" EXACT [] synonym: "heart chamber" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0004160 name: proepicardium def: "An outpouching of the septum transversum[GO]. An embryonic group of progenitor cells that forms near the venous pole of the heart and gives rise to the epicardium[Wiktionary]" [] is_a: UBERON:0003104 ! mesenchyme relationship: part_of UBERON:0004161 ! septum transversum [Term] id: UBERON:0004161 name: septum transversum def: "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." [] synonym: "transverse septum" EXACT [] is_a: UBERON:0003104 ! mesenchyme relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0004164 name: branchiomeric muscle def: "A jaw muscle that arises from cranial mesenchyme and is innervated by cranial nerves." [] synonym: "branchiomeric skeletal muscle" EXACT [] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme [Term] id: UBERON:0004175 name: internal genitalia def: "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals" [] synonym: "internal genitalia" EXACT [] synonym: "internal genitals" EXACT [] synonym: "internal reproductive organ" RELATED [] synonym: "internal sex organ" RELATED [] is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0004176 name: external genitalia def: "The external genitalia are the outer sex organs, such as the penis or vulva in mammals" [] synonym: "external genitalia" EXACT [] synonym: "external reproductive organ" RELATED [] synonym: "external sex organ" RELATED [] is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0004177 name: hemopoietic organ def: "Organ that is part of the hematopoietic system." [] synonym: "haematological system organ" EXACT [] synonym: "haemopoietic system organ" EXACT [] synonym: "hematopoeitic or lymphoid organ" NARROW [] synonym: "hematopoeitic organ" EXACT [] synonym: "hematopoietic system organ" EXACT [] synonym: "lymph organ" NARROW [] synonym: "lymphoid organ" NARROW [] synonym: "organ of haematological system" EXACT [] synonym: "organ of haemopoietic system" EXACT [] synonym: "organ of hematopoietic system" EXACT [] synonym: "organ of organa haemopoietica" EXACT [] synonym: "organa haemopoietica organ" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0002390 ! hematopoietic system [Term] id: UBERON:0004178 name: aorta smooth muscle tissue def: "A portion of smooth muscle tissue that is part of an aorta [Automatically generated definition]." [] synonym: "adult aorta involuntary muscle" EXACT [] synonym: "adult aorta non-striated muscle" EXACT [] synonym: "adult aorta smooth muscle" EXACT [] synonym: "adult aorta smooth muscle tissue" EXACT [] synonym: "aorta involuntary muscle" EXACT [] synonym: "aorta non-striated muscle" EXACT [] synonym: "aorta smooth muscle" EXACT [] synonym: "aortic smooth muscle" EXACT [] synonym: "dorsal aorta involuntary muscle" EXACT [] synonym: "dorsal aorta non-striated muscle" EXACT [] synonym: "dorsal aorta smooth muscle" EXACT [] synonym: "dorsal aorta smooth muscle tissue" EXACT [] synonym: "involuntary muscle of adult aorta" EXACT [] synonym: "involuntary muscle of aorta" EXACT [] synonym: "involuntary muscle of dorsal aorta" EXACT [] synonym: "involuntary muscle of trunk of aortic tree" EXACT [] synonym: "non-striated muscle of adult aorta" EXACT [] synonym: "non-striated muscle of aorta" EXACT [] synonym: "non-striated muscle of dorsal aorta" EXACT [] synonym: "non-striated muscle of trunk of aortic tree" EXACT [] synonym: "smooth muscle of adult aorta" EXACT [] synonym: "smooth muscle of aorta" EXACT [] synonym: "smooth muscle of dorsal aorta" EXACT [] synonym: "smooth muscle of trunk of aortic tree" EXACT [] synonym: "smooth muscle tissue of adult aorta" EXACT [] synonym: "smooth muscle tissue of aorta" EXACT [] synonym: "smooth muscle tissue of dorsal aorta" EXACT [] synonym: "smooth muscle tissue of trunk of aortic tree" EXACT [] synonym: "trunk of aortic tree involuntary muscle" EXACT [] synonym: "trunk of aortic tree non-striated muscle" EXACT [] synonym: "trunk of aortic tree smooth muscle" EXACT [] synonym: "trunk of aortic tree smooth muscle tissue" EXACT [] is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0004179 name: prostate glandular acinus def: "A saclike structure of the prostate gland, comprised of at least three cell layers: an innermost layer of secretory columnar luminal epithelium, a middle layer of squamous basal epithelium that also contains neuroendocrine cells, transit amplifying cells, and stem cells, and an outer layer of smooth muscle intermixed with other stromal cells" [] synonym: "prostatic acinus" EXACT [] synonym: "prostatic follicle" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0009842 ! acinus is_a: UBERON:0014403 ! male anatomical structure relationship: develops_from UBERON:0009843 ! prostate epithelial cord relationship: part_of UBERON:0000428 ! prostate epithelium relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0004180 name: mammary gland fat def: "The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts" [] synonym: "adipose tissue of lactiferous gland" EXACT [] synonym: "adipose tissue of mammary gland" EXACT [] synonym: "fat tissue of lactiferous gland" EXACT [] synonym: "fat tissue of lobe of breast" EXACT [] synonym: "fat tissue of lobe of mammary gland" EXACT [] synonym: "fat tissue of mammary gland" EXACT [] synonym: "fatty tissue of lactiferous gland" EXACT [] synonym: "fatty tissue of lobe of breast" EXACT [] synonym: "fatty tissue of lobe of mammary gland" EXACT [] synonym: "fatty tissue of mammary gland" EXACT [] synonym: "lactiferous gland adipose tissue" EXACT [] synonym: "lactiferous gland fat tissue" EXACT [] synonym: "lactiferous gland fatty tissue" EXACT [] synonym: "lobe of breast adipose tissue" EXACT [] synonym: "lobe of breast fat tissue" EXACT [] synonym: "lobe of breast fatty tissue" EXACT [] synonym: "lobe of mammary gland adipose tissue" EXACT [] synonym: "lobe of mammary gland fat tissue" EXACT [] synonym: "lobe of mammary gland fatty tissue" EXACT [] synonym: "mammary gland adipose tissue" EXACT [] synonym: "mammary gland fat tissue" EXACT [] synonym: "mammary gland fatty tissue" EXACT [] is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003584 ! mammary gland connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0004182 name: mammary gland cord def: "Mammary gland cords form when the mammary gland bud invades the mammary fat" [] is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0005154 ! epithelial cord intersection_of: UBERON:0005154 ! epithelial cord intersection_of: part_of UBERON:0001765 ! mammary duct relationship: part_of UBERON:0001765 ! mammary duct [Term] id: UBERON:0004184 name: prostate gland stroma def: "The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland" [] synonym: "prostate stroma" EXACT [] synonym: "prostatic stroma" EXACT [] synonym: "stroma of glandular part of prostate" NARROW [] synonym: "stroma of prostate" EXACT [] synonym: "stroma of prostate gland" EXACT [] is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0004185 name: endodermal part of digestive tract def: "A portions of the gut that is derived from endoderm." [] synonym: "endodermal gut" EXACT [] synonym: "gut endoderm" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0000925 ! endoderm relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0004186 name: olfactory bulb mitral cell layer def: "The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer" [] synonym: "mitral cell body layer" EXACT [] synonym: "mitral cell layer" EXACT [] synonym: "mitral cell layer of the olfactory bulb" RELATED [] synonym: "olfactory bulb main mitral cell body layer" RELATED [] is_a: UBERON:0004001 ! olfactory bulb layer [Term] id: UBERON:0004188 name: glomerular epithelium def: "The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [] synonym: "epithelium of glomerulus" EXACT [] synonym: "epithelium of kidney glomerulus" EXACT [] synonym: "epithelium of renal glomerulus" EXACT [] synonym: "glomerular epithelial cell" RELATED [] synonym: "kidney glomerular epithelium" EXACT [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus [Term] id: UBERON:0004189 name: glomerular endothelium def: "The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus" [] synonym: "endothelium of renal glomerulus" EXACT [] synonym: "renal glomerulus endothelium" EXACT [] is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0004190 ! renal glomerulus vasculature [Term] id: UBERON:0004190 name: renal glomerulus vasculature def: "The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus" [] synonym: "glomerulus vasculature" EXACT [] synonym: "renal glomerulus vascular network" EXACT [] synonym: "renal glomerulus vasculature" EXACT [] synonym: "vascular network of renal glomerulus" EXACT [] synonym: "vasculature of renal glomerulus" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006544 ! kidney vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus [Term] id: UBERON:0004193 name: loop of Henle ascending limb thin segment def: "A sub-portion of the loop of Henle in the nephron of the kidney that is permeable to ions but not to water" [] synonym: "ascending limb thin segment of loop of Henle" EXACT [] synonym: "ascending thin limb" EXACT [] synonym: "pars ascendens (tubulus attenuatus)" EXACT [] synonym: "thin ascending limb" EXACT [] synonym: "thin ascending limb of loop of Henle" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0008408 ! distal tubular epithelium relationship: part_of UBERON:0003455 ! inner renal medulla loop of henle relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle [Term] id: UBERON:0004198 name: comma-shaped body def: "The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron" [] synonym: "CSB" EXACT [] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0010532 ! primitive nephron relationship: develops_from UBERON:0004209 ! renal vesicle relationship: part_of UBERON:0001285 ! nephron [Term] id: UBERON:0004199 name: S-shaped body def: "The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron" [] synonym: "SSB" EXACT [] synonym: "stage II nephron" EXACT [] is_a: UBERON:0010532 ! primitive nephron relationship: develops_from UBERON:0004198 ! comma-shaped body [Term] id: UBERON:0004201 name: kidney outer medulla inner stripe def: "The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thick and thin portions of nephron tubules" [] synonym: "inner stripe" EXACT [] synonym: "inner stripe of medulla of kidney" EXACT [] synonym: "inner stripe of outer medulla" EXACT [] synonym: "inner stripe of renal medulla" EXACT [] synonym: "outer medulla inner stripe" EXACT [] synonym: "stria interna medullae renalis" EXACT [] is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: UBERON:0004202 name: kidney outer medulla outer stripe def: "The outer stripe is the region of the kidney that lies distal to the line of termination of the straight renal tubules" [] synonym: "outer medulla outer stripe" EXACT [] synonym: "outer stripe" EXACT [] synonym: "outer stripe of medulla of kidney" EXACT [] synonym: "outer stripe of outer medulla" EXACT [] synonym: "outer stripe of renal medulla" EXACT [] synonym: "stria externa medullae renalis" EXACT [] is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: UBERON:0004203 name: cortical collecting duct def: "The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex" [] is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0000025 ! tube intersection_of: part_of UBERON:0001225 ! cortex of kidney intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: UBERON:0004208 name: nephrogenic mesenchyme def: "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron" [] synonym: "mesenchyme of nephron" EXACT [] synonym: "nephron mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0004209 name: renal vesicle def: "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. " [] synonym: "stage I nephron" EXACT [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0007503 ! epithelial vesicle relationship: develops_from UBERON:0004208 ! nephrogenic mesenchyme relationship: part_of UBERON:0001285 ! nephron [Term] id: UBERON:0004211 name: nephron epithelium def: "The nephron epithelium is a tissue that covers the surface of a nephron" [] synonym: "epithelial tissue of nephron" EXACT [] synonym: "epithelium of nephron" EXACT [] synonym: "nephron epithelial tissue" EXACT [] is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001285 ! nephron relationship: part_of UBERON:0001285 ! nephron [Term] id: UBERON:0004212 name: glomerular capillary def: "A capillary that is part of a renal glomerulus [Automatically generated definition]." [] synonym: "blood capillary of renal glomerulus" EXACT [] synonym: "capillary of renal glomerulus" EXACT [] synonym: "capillary vessel of renal glomerulus" EXACT [] synonym: "glomerular capillaries" RELATED [] synonym: "glomerular capillary system" RELATED [] synonym: "renal glomerulus blood capillary" EXACT [] synonym: "renal glomerulus capillary" EXACT [] synonym: "renal glomerulus capillary vessel" EXACT [] is_a: UBERON:0003527 ! kidney capillary intersection_of: UBERON:0001982 ! capillary intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0004190 ! renal glomerulus vasculature [Term] id: UBERON:0004215 name: back nerve def: "A nerve that is part of a back [Automatically generated definition]." [] synonym: "nerve of back" EXACT [] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004219 name: urethra smooth muscle def: "A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition]." [] synonym: "involuntary muscle of urethra" EXACT [] synonym: "non-striated muscle of urethra" EXACT [] synonym: "smooth muscle of urethra" EXACT [] synonym: "smooth muscle tissue of urethra" EXACT [] synonym: "urethra involuntary muscle" EXACT [] synonym: "urethra non-striated muscle" EXACT [] synonym: "urethra smooth muscle tissue" EXACT [] synonym: "urethral smooth muscle" RELATED [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: UBERON:0004220 name: large intestine smooth muscle def: "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." [] synonym: "involuntary muscle of large intestine" EXACT [] synonym: "large intestine involuntary muscle" EXACT [] synonym: "large intestine non-striated muscle" EXACT [] synonym: "large intestine smooth muscle tissue" EXACT [] synonym: "non-striated muscle of large intestine" EXACT [] synonym: "smooth muscle of large intestine" EXACT [] synonym: "smooth muscle tissue of large intestine" EXACT [] is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine [Term] id: UBERON:0004221 name: intestine smooth muscle def: "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." [] synonym: "bowel involuntary muscle" EXACT [] synonym: "bowel non-striated muscle" EXACT [] synonym: "bowel smooth muscle" EXACT [] synonym: "bowel smooth muscle tissue" EXACT [] synonym: "intestinal smooth muscle" RELATED [] synonym: "intestine involuntary muscle" EXACT [] synonym: "intestine non-striated muscle" EXACT [] synonym: "intestine smooth muscle tissue" EXACT [] synonym: "involuntary muscle of bowel" EXACT [] synonym: "involuntary muscle of intestine" EXACT [] synonym: "non-striated muscle of bowel" EXACT [] synonym: "non-striated muscle of intestine" EXACT [] synonym: "smooth muscle of bowel" EXACT [] synonym: "smooth muscle of intestine" EXACT [] synonym: "smooth muscle tissue of bowel" EXACT [] synonym: "smooth muscle tissue of intestine" EXACT [] is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0004222 name: stomach smooth muscle def: "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." [] synonym: "gastric muscle" RELATED [] synonym: "gastric smooth muscle" RELATED [] synonym: "involuntary muscle of stomach" EXACT [] synonym: "involuntary muscle of ventriculus" EXACT [] synonym: "non-striated muscle of stomach" EXACT [] synonym: "non-striated muscle of ventriculus" EXACT [] synonym: "smooth muscle of stomach" EXACT [] synonym: "smooth muscle of ventriculus" EXACT [] synonym: "smooth muscle tissue of stomach" EXACT [] synonym: "smooth muscle tissue of ventriculus" EXACT [] synonym: "stomach involuntary muscle" EXACT [] synonym: "stomach muscle" RELATED [] synonym: "stomach non-striated muscle" EXACT [] synonym: "stomach smooth muscle tissue" EXACT [] synonym: "ventriculus involuntary muscle" EXACT [] synonym: "ventriculus non-striated muscle" EXACT [] synonym: "ventriculus smooth muscle" EXACT [] synonym: "ventriculus smooth muscle tissue" EXACT [] is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001167 ! wall of stomach [Term] id: UBERON:0004223 name: vagina smooth muscle def: "A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition]." [] synonym: "involuntary muscle of vagina" EXACT [] synonym: "non-striated muscle of vagina" EXACT [] synonym: "smooth muscle of vagina" EXACT [] synonym: "smooth muscle tissue of vagina" EXACT [] synonym: "vagina involuntary muscle" EXACT [] synonym: "vagina non-striated muscle" EXACT [] synonym: "vagina smooth muscle" RELATED [] synonym: "vagina smooth muscle tissue" EXACT [] synonym: "vaginal smooth muscle" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0004225 name: respiratory system smooth muscle def: "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." [] synonym: "airway smooth muscle" RELATED [] synonym: "airway smooth muscle cell" RELATED [] synonym: "apparatus respiratorius involuntary muscle" EXACT [] synonym: "apparatus respiratorius non-striated muscle" EXACT [] synonym: "apparatus respiratorius smooth muscle" EXACT [] synonym: "apparatus respiratorius smooth muscle tissue" EXACT [] synonym: "involuntary muscle of apparatus respiratorius" EXACT [] synonym: "involuntary muscle of respiratory system" EXACT [] synonym: "non-striated muscle of apparatus respiratorius" EXACT [] synonym: "non-striated muscle of respiratory system" EXACT [] synonym: "respiratory smooth muscle" EXACT [] synonym: "respiratory system involuntary muscle" EXACT [] synonym: "respiratory system non-striated muscle" EXACT [] synonym: "respiratory system smooth muscle tissue" EXACT [] synonym: "smooth muscle of apparatus respiratorius" EXACT [] synonym: "smooth muscle of respiratory system" EXACT [] synonym: "smooth muscle tissue of apparatus respiratorius" EXACT [] synonym: "smooth muscle tissue of respiratory system" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0004226 name: gastrointestinal system smooth muscle def: "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." [] synonym: "digestive system involuntary muscle" EXACT [] synonym: "digestive system non-striated muscle" EXACT [] synonym: "digestive system smooth muscle" EXACT [] synonym: "digestive system smooth muscle tissue" EXACT [] synonym: "gastrointestinal system involuntary muscle" EXACT [] synonym: "gastrointestinal system non-striated muscle" EXACT [] synonym: "gastrointestinal system smooth muscle tissue" EXACT [] synonym: "involuntary muscle of digestive system" EXACT [] synonym: "involuntary muscle of gastrointestinal system" EXACT [] synonym: "non-striated muscle of digestive system" EXACT [] synonym: "non-striated muscle of gastrointestinal system" EXACT [] synonym: "smooth muscle of digestive system" EXACT [] synonym: "smooth muscle of gastrointestinal system" EXACT [] synonym: "smooth muscle tissue of digestive system" EXACT [] synonym: "smooth muscle tissue of gastrointestinal system" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004227 name: kidney pelvis smooth muscle def: "A portion of smooth muscle tissue that is part of a renal pelvis [Automatically generated definition]." [] synonym: "involuntary muscle of kidney pelvis" EXACT [] synonym: "involuntary muscle of pelvis of ureter" EXACT [] synonym: "involuntary muscle of renal pelvis" EXACT [] synonym: "kidney pelvis involuntary muscle" EXACT [] synonym: "kidney pelvis non-striated muscle" EXACT [] synonym: "kidney pelvis smooth muscle tissue" EXACT [] synonym: "non-striated muscle of kidney pelvis" EXACT [] synonym: "non-striated muscle of pelvis of ureter" EXACT [] synonym: "non-striated muscle of renal pelvis" EXACT [] synonym: "pelvis of ureter involuntary muscle" EXACT [] synonym: "pelvis of ureter non-striated muscle" EXACT [] synonym: "pelvis of ureter smooth muscle" EXACT [] synonym: "pelvis of ureter smooth muscle tissue" EXACT [] synonym: "renal pelvis involuntary muscle" EXACT [] synonym: "renal pelvis non-striated muscle" EXACT [] synonym: "renal pelvis smooth muscle" EXACT [] synonym: "renal pelvis smooth muscle tissue" EXACT [] synonym: "smooth muscle of kidney pelvis" EXACT [] synonym: "smooth muscle of pelvis of ureter" EXACT [] synonym: "smooth muscle of renal pelvis" EXACT [] synonym: "smooth muscle tissue of kidney pelvis" EXACT [] synonym: "smooth muscle tissue of pelvis of ureter" EXACT [] synonym: "smooth muscle tissue of renal pelvis" EXACT [] is_a: UBERON:0009919 ! ureter smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis [Term] id: UBERON:0004228 name: urinary bladder smooth muscle def: "A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition]." [] synonym: "bladder involuntary muscle" EXACT [] synonym: "bladder non-striated muscle" EXACT [] synonym: "bladder smooth muscle" EXACT [] synonym: "bladder smooth muscle tissue" EXACT [] synonym: "involuntary muscle of bladder" EXACT [] synonym: "involuntary muscle of urinary bladder" EXACT [] synonym: "non-striated muscle of bladder" EXACT [] synonym: "non-striated muscle of urinary bladder" EXACT [] synonym: "smooth muscle of bladder" EXACT [] synonym: "smooth muscle of urinary bladder" EXACT [] synonym: "smooth muscle tissue of bladder" EXACT [] synonym: "smooth muscle tissue of urinary bladder" EXACT [] synonym: "urinary bladder involuntary muscle" EXACT [] synonym: "urinary bladder muscle" EXACT [] synonym: "urinary bladder non-striated muscle" EXACT [] synonym: "urinary bladder smooth muscle tissue" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder [Term] id: UBERON:0004229 name: urinary bladder trigone smooth muscle def: "A portion of smooth muscle tissue that is part of a trigone of urinary bladder [Automatically generated definition]." [] synonym: "deep trigone involuntary muscle" EXACT [] synonym: "deep trigone non-striated muscle" EXACT [] synonym: "deep trigone smooth muscle" EXACT [] synonym: "deep trigone smooth muscle tissue" EXACT [] synonym: "involuntary muscle of deep trigone" EXACT [] synonym: "involuntary muscle of Lieutaud's trigone" EXACT [] synonym: "involuntary muscle of trigone of bladder" EXACT [] synonym: "involuntary muscle of trigone of urinary bladder" EXACT [] synonym: "involuntary muscle of urinary bladder trigone" EXACT [] synonym: "involuntary muscle of vesical trigone" EXACT [] synonym: "Lieutaud's trigone involuntary muscle" EXACT [] synonym: "Lieutaud's trigone non-striated muscle" EXACT [] synonym: "Lieutaud's trigone smooth muscle" EXACT [] synonym: "Lieutaud's trigone smooth muscle tissue" EXACT [] synonym: "non-striated muscle of deep trigone" EXACT [] synonym: "non-striated muscle of Lieutaud's trigone" EXACT [] synonym: "non-striated muscle of trigone of bladder" EXACT [] synonym: "non-striated muscle of trigone of urinary bladder" EXACT [] synonym: "non-striated muscle of urinary bladder trigone" EXACT [] synonym: "non-striated muscle of vesical trigone" EXACT [] synonym: "smooth muscle of deep trigone" EXACT [] synonym: "smooth muscle of Lieutaud's trigone" EXACT [] synonym: "smooth muscle of trigone of bladder" EXACT [] synonym: "smooth muscle of trigone of urinary bladder" EXACT [] synonym: "smooth muscle of urinary bladder trigone" EXACT [] synonym: "smooth muscle of vesical trigone" EXACT [] synonym: "smooth muscle tissue of deep trigone" EXACT [] synonym: "smooth muscle tissue of Lieutaud's trigone" EXACT [] synonym: "smooth muscle tissue of trigone of bladder" EXACT [] synonym: "smooth muscle tissue of trigone of urinary bladder" EXACT [] synonym: "smooth muscle tissue of urinary bladder trigone" EXACT [] synonym: "smooth muscle tissue of vesical trigone" EXACT [] synonym: "trigone of bladder involuntary muscle" EXACT [] synonym: "trigone of bladder non-striated muscle" EXACT [] synonym: "trigone of bladder smooth muscle" EXACT [] synonym: "trigone of bladder smooth muscle tissue" EXACT [] synonym: "trigone of urinary bladder involuntary muscle" EXACT [] synonym: "trigone of urinary bladder non-striated muscle" EXACT [] synonym: "trigone of urinary bladder smooth muscle" EXACT [] synonym: "trigone of urinary bladder smooth muscle tissue" EXACT [] synonym: "urinary bladder trigone involuntary muscle" EXACT [] synonym: "urinary bladder trigone muscle" EXACT [] synonym: "urinary bladder trigone non-striated muscle" EXACT [] synonym: "urinary bladder trigone smooth muscle tissue" EXACT [] synonym: "vesical trigone involuntary muscle" EXACT [] synonym: "vesical trigone non-striated muscle" EXACT [] synonym: "vesical trigone smooth muscle" EXACT [] synonym: "vesical trigone smooth muscle tissue" EXACT [] is_a: UBERON:0004228 ! urinary bladder smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder relationship: part_of UBERON:0001257 ! trigone of urinary bladder [Term] id: UBERON:0004231 name: anal region smooth muscle def: "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." [] synonym: "anal part of perineum involuntary muscle" EXACT [] synonym: "anal part of perineum non-striated muscle" EXACT [] synonym: "anal part of perineum smooth muscle" EXACT [] synonym: "anal part of perineum smooth muscle tissue" EXACT [] synonym: "anal region involuntary muscle" EXACT [] synonym: "anal region non-striated muscle" EXACT [] synonym: "anal region smooth muscle tissue" EXACT [] synonym: "anal triangle involuntary muscle" EXACT [] synonym: "anal triangle non-striated muscle" EXACT [] synonym: "anal triangle smooth muscle" EXACT [] synonym: "anal triangle smooth muscle tissue" EXACT [] synonym: "involuntary muscle of anal part of perineum" EXACT [] synonym: "involuntary muscle of anal region" EXACT [] synonym: "involuntary muscle of anal triangle" EXACT [] synonym: "non-striated muscle of anal part of perineum" EXACT [] synonym: "non-striated muscle of anal region" EXACT [] synonym: "non-striated muscle of anal triangle" EXACT [] synonym: "smooth muscle of anal part of perineum" EXACT [] synonym: "smooth muscle of anal region" EXACT [] synonym: "smooth muscle of anal triangle" EXACT [] synonym: "smooth muscle tissue of anal part of perineum" EXACT [] synonym: "smooth muscle tissue of anal region" EXACT [] synonym: "smooth muscle tissue of anal triangle" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0004232 name: lymphatic vessel smooth muscle def: "A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition]." [] synonym: "involuntary muscle of lymph vessel" EXACT [] synonym: "involuntary muscle of lymphatic vessel" EXACT [] synonym: "lymph vessel involuntary muscle" EXACT [] synonym: "lymph vessel non-striated muscle" EXACT [] synonym: "lymph vessel smooth muscle" EXACT [] synonym: "lymph vessel smooth muscle tissue" EXACT [] synonym: "lymphatic vessel involuntary muscle" EXACT [] synonym: "lymphatic vessel non-striated muscle" EXACT [] synonym: "lymphatic vessel smooth muscle tissue" EXACT [] synonym: "non-striated muscle of lymph vessel" EXACT [] synonym: "non-striated muscle of lymphatic vessel" EXACT [] synonym: "smooth muscle of lymph vessel" EXACT [] synonym: "smooth muscle of lymphatic vessel" EXACT [] synonym: "smooth muscle tissue of lymph vessel" EXACT [] synonym: "smooth muscle tissue of lymphatic vessel" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0004233 name: lower respiratory tract smooth muscle def: "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." [] synonym: "involuntary muscle of lower respiratory tract" EXACT [] synonym: "lower respiratory tract involuntary muscle" EXACT [] synonym: "lower respiratory tract non-striated muscle" EXACT [] synonym: "lower respiratory tract smooth muscle tissue" EXACT [] synonym: "non-striated muscle of lower respiratory tract" EXACT [] synonym: "smooth muscle of lower respiratory tract" EXACT [] synonym: "smooth muscle tissue of lower respiratory tract" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004225 ! respiratory system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0004234 name: iris smooth muscle def: "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." [] synonym: "involuntary muscle of iris" EXACT [] synonym: "iridial smooth muscle" EXACT [] synonym: "iris involuntary muscle" EXACT [] synonym: "iris non-striated muscle" EXACT [] synonym: "iris smooth muscle tissue" EXACT [] synonym: "non-striated muscle of iris" EXACT [] synonym: "smooth muscle of iris" EXACT [] synonym: "smooth muscle tissue of iris" EXACT [] is_a: UBERON:0003386 ! smooth muscle of eye intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001606 ! muscle of iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0004235 name: mammary gland smooth muscle def: "A portion of smooth muscle tissue that is part of a lactiferous gland [Automatically generated definition]." [] synonym: "involuntary muscle of lactiferous gland" EXACT [] synonym: "involuntary muscle of lobe of breast" EXACT [] synonym: "involuntary muscle of lobe of mammary gland" EXACT [] synonym: "involuntary muscle of mammary gland" EXACT [] synonym: "lactiferous gland involuntary muscle" EXACT [] synonym: "lactiferous gland non-striated muscle" EXACT [] synonym: "lactiferous gland smooth muscle" EXACT [] synonym: "lactiferous gland smooth muscle tissue" EXACT [] synonym: "lobe of breast involuntary muscle" EXACT [] synonym: "lobe of breast non-striated muscle" EXACT [] synonym: "lobe of breast smooth muscle" EXACT [] synonym: "lobe of breast smooth muscle tissue" EXACT [] synonym: "lobe of mammary gland involuntary muscle" EXACT [] synonym: "lobe of mammary gland non-striated muscle" EXACT [] synonym: "lobe of mammary gland smooth muscle" EXACT [] synonym: "lobe of mammary gland smooth muscle tissue" EXACT [] synonym: "mammary gland involuntary muscle" EXACT [] synonym: "mammary gland non-striated muscle" EXACT [] synonym: "mammary gland smooth muscle tissue" EXACT [] synonym: "non-striated muscle of lactiferous gland" EXACT [] synonym: "non-striated muscle of lobe of breast" EXACT [] synonym: "non-striated muscle of lobe of mammary gland" EXACT [] synonym: "non-striated muscle of mammary gland" EXACT [] synonym: "smooth muscle of lactiferous gland" EXACT [] synonym: "smooth muscle of lobe of breast" EXACT [] synonym: "smooth muscle of lobe of mammary gland" EXACT [] synonym: "smooth muscle of mammary gland" EXACT [] synonym: "smooth muscle tissue of lactiferous gland" EXACT [] synonym: "smooth muscle tissue of lobe of breast" EXACT [] synonym: "smooth muscle tissue of lobe of mammary gland" EXACT [] synonym: "smooth muscle tissue of mammary gland" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0004236 name: arteriole smooth muscle def: "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." [] is_a: UBERON:0002111 ! artery smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole [Term] id: UBERON:0004237 name: blood vessel smooth muscle def: "smooth muscle found within, and composing the majority of the wall of blood vessels." [] synonym: "blood vessel involuntary muscle" EXACT [] synonym: "blood vessel non-striated muscle" EXACT [] synonym: "blood vessel smooth muscle tissue" EXACT [] synonym: "involuntary muscle of blood vessel" EXACT [] synonym: "non-striated muscle of blood vessel" EXACT [] synonym: "smooth muscle of blood vessel" EXACT [] synonym: "smooth muscle tissue of blood vessel" EXACT [] synonym: "vascular smooth muscle" EXACT [] synonym: "vascular smooth muscle tissue" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel [Term] id: UBERON:0004238 name: spleen smooth muscle def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [] synonym: "involuntary muscle of spleen" EXACT [] synonym: "non-striated muscle of spleen" EXACT [] synonym: "smooth muscle of spleen" EXACT [] synonym: "smooth muscle tissue of spleen" EXACT [] synonym: "spleen involuntary muscle" EXACT [] synonym: "spleen non-striated muscle" EXACT [] synonym: "spleen smooth muscle tissue" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004239 name: small intestine smooth muscle def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." [] synonym: "involuntary muscle of small bowel" EXACT [] synonym: "involuntary muscle of small intestine" EXACT [] synonym: "non-striated muscle of small bowel" EXACT [] synonym: "non-striated muscle of small intestine" EXACT [] synonym: "small bowel involuntary muscle" EXACT [] synonym: "small bowel non-striated muscle" EXACT [] synonym: "small bowel smooth muscle" EXACT [] synonym: "small bowel smooth muscle tissue" EXACT [] synonym: "small intestine involuntary muscle" EXACT [] synonym: "small intestine non-striated muscle" EXACT [] synonym: "small intestine smooth muscle tissue" EXACT [] synonym: "smooth muscle of small bowel" EXACT [] synonym: "smooth muscle of small intestine" EXACT [] synonym: "smooth muscle tissue of small bowel" EXACT [] synonym: "smooth muscle tissue of small intestine" EXACT [] is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0004240 name: gall bladder smooth muscle def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." [] synonym: "biliary smooth muscle" RELATED [] synonym: "gall bladder involuntary muscle" EXACT [] synonym: "gall bladder non-striated muscle" EXACT [] synonym: "gall bladder smooth muscle tissue" EXACT [] synonym: "gallbladder involuntary muscle" EXACT [] synonym: "gallbladder non-striated muscle" EXACT [] synonym: "gallbladder smooth muscle" EXACT [] synonym: "gallbladder smooth muscle tissue" EXACT [] synonym: "involuntary muscle of gall bladder" EXACT [] synonym: "involuntary muscle of gallbladder" EXACT [] synonym: "non-striated muscle of gall bladder" EXACT [] synonym: "non-striated muscle of gallbladder" EXACT [] synonym: "smooth muscle of gall bladder" EXACT [] synonym: "smooth muscle of gallbladder" EXACT [] synonym: "smooth muscle tissue of gall bladder" EXACT [] synonym: "smooth muscle tissue of gallbladder" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: UBERON:0004242 name: bronchus smooth muscle def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." [] synonym: "bronchi involuntary muscle" EXACT [] synonym: "bronchi non-striated muscle" EXACT [] synonym: "bronchi smooth muscle" EXACT [] synonym: "bronchi smooth muscle tissue" EXACT [] synonym: "bronchial trunk involuntary muscle" EXACT [] synonym: "bronchial trunk non-striated muscle" EXACT [] synonym: "bronchial trunk smooth muscle" EXACT [] synonym: "bronchial trunk smooth muscle tissue" EXACT [] synonym: "bronchus involuntary muscle" EXACT [] synonym: "bronchus non-striated muscle" EXACT [] synonym: "bronchus smooth muscle tissue" EXACT [] synonym: "involuntary muscle of bronchi" EXACT [] synonym: "involuntary muscle of bronchial trunk" EXACT [] synonym: "involuntary muscle of bronchus" EXACT [] synonym: "non-striated muscle of bronchi" EXACT [] synonym: "non-striated muscle of bronchial trunk" EXACT [] synonym: "non-striated muscle of bronchus" EXACT [] synonym: "smooth muscle of bronchi" EXACT [] synonym: "smooth muscle of bronchial trunk" EXACT [] synonym: "smooth muscle of bronchus" EXACT [] synonym: "smooth muscle tissue of bronchi" EXACT [] synonym: "smooth muscle tissue of bronchial trunk" EXACT [] synonym: "smooth muscle tissue of bronchus" EXACT [] is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0004243 name: prostate gland smooth muscle def: "A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition]." [] synonym: "involuntary muscle of prostate" EXACT [] synonym: "involuntary muscle of prostate gland" EXACT [] synonym: "muscular tissue of prostate" EXACT [] synonym: "non-striated muscle of prostate" EXACT [] synonym: "non-striated muscle of prostate gland" EXACT [] synonym: "prostate gland involuntary muscle" EXACT [] synonym: "prostate gland non-striated muscle" EXACT [] synonym: "prostate gland smooth muscle tissue" EXACT [] synonym: "prostate involuntary muscle" EXACT [] synonym: "prostate non-striated muscle" EXACT [] synonym: "prostate smooth muscle" EXACT [] synonym: "prostate smooth muscle tissue" EXACT [] synonym: "smooth muscle of prostate" EXACT [] synonym: "smooth muscle of prostate gland" EXACT [] synonym: "smooth muscle tissue of prostate" EXACT [] synonym: "smooth muscle tissue of prostate gland" EXACT [] synonym: "substantia muscularis prostatae" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0008715 ! muscle tissue of prostate intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0004245 name: oviduct smooth muscle def: "A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition]." [] synonym: "fallopian tube involuntary muscle" EXACT [] synonym: "fallopian tube non-striated muscle" EXACT [] synonym: "fallopian tube smooth muscle" EXACT [] synonym: "fallopian tube smooth muscle tissue" EXACT [] synonym: "involuntary muscle of fallopian tube" EXACT [] synonym: "non-striated muscle of fallopian tube" EXACT [] synonym: "smooth muscle of fallopian tube" EXACT [] synonym: "smooth muscle tissue of fallopian tube" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003889 ! fallopian tube relationship: part_of UBERON:0003889 ! fallopian tube [Term] id: UBERON:0004246 name: outflow tract smooth muscle def: "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." [] synonym: "involuntary muscle of outflow tract" EXACT [] synonym: "non-striated muscle of outflow tract" EXACT [] synonym: "outflow tract involuntary muscle" EXACT [] synonym: "outflow tract non-striated muscle" EXACT [] synonym: "outflow tract smooth muscle tissue" EXACT [] synonym: "smooth muscle of outflow tract" EXACT [] synonym: "smooth muscle tissue of outflow tract" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004247 name: back bone def: "A bone that is part of a back [Automatically generated definition]." [] synonym: "back bone organ" EXACT [] synonym: "bone of back" EXACT [] synonym: "bone organ of back" EXACT [] is_a: UBERON:0001474 ! bone element is_a: UBERON:0005174 ! dorsal region organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004253 name: skin muscle def: "A muscle organ that is part of a skin of body [Automatically generated definition]." [] synonym: "muscle of integumental system" EXACT [] synonym: "muscle organ of skin" EXACT [] synonym: "skin muscle organ" EXACT [] is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0002416 ! integumental system relationship: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0004258 name: back blood vessel def: "A blood vessel that is part of a back [Automatically generated definition]." [] synonym: "blood vessel of back" EXACT [] is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004265 name: outflow tract myocardium def: "A myocardium that is part of a outflow tract [Automatically generated definition]." [] synonym: "cardiac muscle of outflow tract" EXACT [] synonym: "heart muscle of outflow tract" EXACT [] synonym: "heart myocardium of outflow tract" EXACT [] synonym: "muscle of heart of outflow tract" EXACT [] synonym: "myocardium of outflow tract" EXACT [] synonym: "outflow tract cardiac muscle" EXACT [] synonym: "outflow tract heart muscle" EXACT [] synonym: "outflow tract heart myocardium" EXACT [] synonym: "outflow tract muscle of heart" EXACT [] is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004267 name: back connective tissue def: "A portion of connective tissue that is part of a back [Automatically generated definition]." [] synonym: "back portion of connective tissue" EXACT [] synonym: "back textus connectivus" EXACT [] synonym: "connective tissue of back" EXACT [] synonym: "portion of connective tissue of back" EXACT [] synonym: "textus connectivus of back" EXACT [] is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004271 name: outflow tract pericardium def: "A pericardium that is part of a outflow tract [Automatically generated definition]." [] synonym: "pericardium of outflow tract" EXACT [] is_a: UBERON:0002407 ! pericardium intersection_of: UBERON:0002407 ! pericardium intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004273 name: cartilaginous joint suture def: "A cranial suture that is part of a cartilaginous joint [Automatically generated definition]." [] synonym: "articulatio cartilaginea cranial suture" EXACT [] synonym: "articulatio cartilaginea cranial sutures" EXACT [] synonym: "articulatio cartilaginea cranial sutures set" EXACT [] synonym: "articulatio cartilaginea cranium suture" EXACT [] synonym: "articulatio cartilaginea suture of cranium" EXACT [] synonym: "cartilaginous joint cranial suture" EXACT [] synonym: "cartilaginous joint cranial sutures" EXACT [] synonym: "cartilaginous joint cranial sutures set" EXACT [] synonym: "cartilaginous joint cranium suture" EXACT [] synonym: "cartilaginous joint suture of cranium" EXACT [] synonym: "cranial suture of articulatio cartilaginea" EXACT [] synonym: "cranial suture of cartilaginous joint" EXACT [] synonym: "cranial sutures of articulatio cartilaginea" EXACT [] synonym: "cranial sutures of cartilaginous joint" EXACT [] synonym: "cranial sutures set of articulatio cartilaginea" EXACT [] synonym: "cranial sutures set of cartilaginous joint" EXACT [] synonym: "cranium suture of articulatio cartilaginea" EXACT [] synonym: "cranium suture of cartilaginous joint" EXACT [] synonym: "suture of cranium of articulatio cartilaginea" EXACT [] synonym: "suture of cranium of cartilaginous joint" EXACT [] is_a: UBERON:0003685 ! cranial suture intersection_of: UBERON:0003685 ! cranial suture intersection_of: part_of UBERON:0002213 ! cartilaginous joint relationship: part_of UBERON:0002213 ! cartilaginous joint [Term] id: UBERON:0004274 name: lateral ventricle choroid plexus epithelium def: "A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition]." [] synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of lateral ventricle" EXACT [] synonym: "chorioid plexus of cerebral hemisphere epithelium of lateral ventricle" EXACT [] synonym: "choroid plexus epithelial tissue of lateral ventricle" EXACT [] synonym: "choroid plexus epithelium of lateral ventricle" EXACT [] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT [] synonym: "epithelial tissue of choroid plexus of lateral ventricle" EXACT [] synonym: "epithelium of chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT [] synonym: "epithelium of choroid plexus of lateral ventricle" EXACT [] synonym: "lateral ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT [] synonym: "lateral ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT [] synonym: "lateral ventricle choroid plexus epithelial tissue" EXACT [] synonym: "lateral ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [] synonym: "lateral ventricle epithelial tissue of choroid plexus" EXACT [] synonym: "lateral ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT [] synonym: "lateral ventricle epithelium of choroid plexus" EXACT [] is_a: UBERON:0003911 ! choroid plexus epithelium is_a: UBERON:0004643 ! lateral ventricle ependyma intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002307 ! choroid plexus of lateral ventricle relationship: part_of UBERON:0002307 ! choroid plexus of lateral ventricle [Term] id: UBERON:0004276 name: fourth ventricle choroid plexus epithelium def: "A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition]." [] synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of fourth ventricle" EXACT [] synonym: "chorioid plexus of cerebral hemisphere epithelium of fourth ventricle" EXACT [] synonym: "choroid plexus epithelial tissue of fourth ventricle" EXACT [] synonym: "choroid plexus epithelium of fourth ventricle" EXACT [] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT [] synonym: "epithelial tissue of choroid plexus of fourth ventricle" EXACT [] synonym: "epithelium of chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT [] synonym: "epithelium of choroid plexus of fourth ventricle" EXACT [] synonym: "fourth ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT [] synonym: "fourth ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT [] synonym: "fourth ventricle choroid plexus epithelial tissue" EXACT [] synonym: "fourth ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [] synonym: "fourth ventricle epithelial tissue of choroid plexus" EXACT [] synonym: "fourth ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT [] synonym: "fourth ventricle epithelium of choroid plexus" EXACT [] is_a: UBERON:0003911 ! choroid plexus epithelium is_a: UBERON:0004644 ! fourth ventricle ependyma is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0003911 ! choroid plexus epithelium intersection_of: part_of UBERON:0002422 ! fourth ventricle relationship: part_of UBERON:0002290 ! choroid plexus of fourth ventricle relationship: part_of UBERON:0002422 ! fourth ventricle [Term] id: UBERON:0004277 name: eye muscle def: "A muscle that is part of the eye region." [] is_a: UBERON:0002376 ! muscle of head is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0004288 name: skeleton def: "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." [] synonym: "set of all bones" EXACT [] synonym: "set of bones of body" EXACT [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0004290 name: dermomyotome def: "The bilaminar epithelium formed from the myotome and dermatome." [] synonym: "dermamyotome" RELATED [] synonym: "dermomyotomes" RELATED [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0002329 ! somite relationship: part_of UBERON:0000926 ! mesoderm [Term] id: UBERON:0004291 name: heart rudiment def: "a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [] synonym: "heart cone" EXACT [] synonym: "rudimentary heart" EXACT [] is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0003084 ! heart primordium relationship: develops_from UBERON:0004139 ! cardiogenic plate [Term] id: UBERON:0004294 name: glomerular capillary endothelium def: "An endothelium that is part of a glomerular capillary." [] synonym: "renal glomerulus capillary endothelium" EXACT [] is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004189 ! glomerular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0004212 ! glomerular capillary relationship: part_of UBERON:0004212 ! glomerular capillary [Term] id: UBERON:0004296 name: respiratory system lymphatic vessel smooth muscle def: "A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [] synonym: "smooth muscle of lymph vessel of respiratory system" EXACT [] is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004232 ! lymphatic vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003456 ! respiratory system lymphatic vessel relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel [Term] id: UBERON:0004297 name: respiratory system blood vessel smooth muscle def: "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [] synonym: "smooth muscle tissue of blood vessel of respiratory system" EXACT [] is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003504 ! respiratory system blood vessel relationship: part_of UBERON:0003504 ! respiratory system blood vessel [Term] id: UBERON:0004340 name: allantois def: "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG]." [] synonym: "allantoic bud" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0001040 ! yolk sac relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm [Term] id: UBERON:0004348 name: optic eminence def: "the embryonic structure that gives rise to the corneal ectoderm" [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0004362 name: pharyngeal arch 1 def: "First of six branchial arches that develops in fetal life during the fourth week of development.[1] It is located between the stomodeum and the first pharyngeal groove." [] synonym: "1st arch" RELATED [] synonym: "1st pharyngeal arch" EXACT [] synonym: "1st visceral arch" RELATED [] synonym: "arcus pharyngeus primus" RELATED [] synonym: "branchial arch 1" EXACT [] synonym: "first branchial arch" EXACT [] synonym: "first pharyngeal arch" EXACT [] synonym: "first visceral arch" EXACT [] synonym: "mandibular arch" EXACT [] synonym: "visceral arch 1" EXACT [] is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0004363 name: aortic arch def: "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]" [] synonym: "a. arcuum pharyngeorum" RELATED [] synonym: "aortic arch artery" RELATED [] synonym: "aortic arches" EXACT [] synonym: "arteriae arcuum pharyngeorum" RELATED [] synonym: "branchial aortic arches " EXACT [] synonym: "branchial arch artery" EXACT [] synonym: "embryonic aortic arch artery" EXACT [] synonym: "pharyngeal arch artery" EXACT [] synonym: "pharyngeal arch artery" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003469 ! respiratory system artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0007303 ! pharyngeal vasculature [Term] id: UBERON:0004456 name: entire sense organ system def: "Sum of all sensory systems in an organism." [] synonym: "sense organ system" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0004457 name: cavity lining is_a: UBERON:0004458 ! body cavity or lining is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0004458 name: body cavity or lining is_a: UBERON:0001062 ! anatomical entity union_of: UBERON:0002323 ! coelemic cavity lumen union_of: UBERON:0004457 ! cavity lining [Term] id: UBERON:0004461 name: musculature of head def: "Any collection of muscles that is part of a head [Automatically generated definition]." [] synonym: "head musculature" EXACT [] synonym: "muscle group of head" EXACT [] synonym: "muscles of head" EXACT [] synonym: "musculi capitis" EXACT [] synonym: "set of muscles of head" EXACT [] is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0000033 ! head relationship: develops_from UBERON:0005253 ! head mesenchyme relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0013700 ! axial musculature [Term] id: UBERON:0004464 name: musculature of thorax def: "Any collection of muscles that is part of a thorax [Automatically generated definition]." [] synonym: "muscle group of thorax" EXACT [] synonym: "muscles of thorax" EXACT [] synonym: "musculi thoracis" EXACT [] synonym: "set of muscles of thorax" EXACT [] synonym: "thoracic musculature" EXACT [] is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0004465 name: musculature of neck def: "Any collection of muscles that is part of a neck [Automatically generated definition]." [] synonym: "cervical muscles" EXACT [] synonym: "muscle group of neck" EXACT [] synonym: "muscles of neck" EXACT [] synonym: "musculi cervicis" EXACT [] synonym: "musculi colli" EXACT [] synonym: "neck musculature" EXACT [] synonym: "set of muscles of neck" EXACT [] is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0004468 name: set of muscles of vertebral column def: "Any collection of muscles that is part of a vertebral column [Automatically generated definition]." [] synonym: "muscle group of vertebral column" EXACT [] is_a: UBERON:0001015 ! musculature is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0001130 ! vertebral column relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0004469 name: musculature of back def: "Any collection of muscles that is part of a back [Automatically generated definition]." [] synonym: "muscle group of back" EXACT [] synonym: "muscles of back" EXACT [] synonym: "musculi dorsi" EXACT [] synonym: "set of muscles of back" EXACT [] is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004472 name: musculature of chest def: "Any collection of muscles that is part of a chest [Automatically generated definition]." [] synonym: "chest musculature" EXACT [] synonym: "set of muscles of chest" EXACT [] is_a: UBERON:0004464 ! musculature of thorax intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0004473 name: musculature of face def: "Any collection of muscles that is part of a face." [] synonym: "entire facial musculature" EXACT [] synonym: "facial muscles" EXACT [] synonym: "muscle group of face" EXACT [] synonym: "musculi faciei" EXACT [] synonym: "set of facial muscles" RELATED [] synonym: "set of muscles of face" RELATED [] is_a: UBERON:0004461 ! musculature of head intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0001456 ! face relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0004477 name: tongue musculature def: "Any collection of muscles that is part of a tongue [Automatically generated definition]." [] synonym: "muscle group of tongue" EXACT [] synonym: "muscles of tongue" EXACT [] synonym: "musculi linguae" EXACT [] synonym: "set of muscles of tongue" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004461 ! musculature of head intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0004479 name: musculature of trunk def: "Any collection of muscles that is part of a trunk [Automatically generated definition]." [] synonym: "muscle group of trunk" EXACT [] synonym: "set of muscles of trunk" EXACT [] is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0004490 name: cardiac muscle tissue of atrium def: "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." [] is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0004491 name: cardiac muscle tissue of interatrial septum def: "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." [] is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002085 ! interatrial septum relationship: part_of UBERON:0002085 ! interatrial septum [Term] id: UBERON:0004492 name: cardiac muscle tissue of cardiac septum def: "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." [] is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002099 ! cardiac septum relationship: part_of UBERON:0002099 ! cardiac septum [Term] id: UBERON:0004493 name: cardiac muscle tissue of myocardium def: "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." [] is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002349 ! myocardium relationship: part_of UBERON:0002349 ! myocardium [Term] id: UBERON:0004515 name: smooth muscle tissue of bronchiole def: "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." [] synonym: "smooth muscle tissue of lobular bronchiole" EXACT [] is_a: UBERON:0004242 ! bronchus smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002186 ! bronchiole relationship: part_of UBERON:0002186 ! bronchiole [Term] id: UBERON:0004516 name: smooth muscle tissue of terminal bronchiole def: "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." [] is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002187 ! terminal bronchiole relationship: part_of UBERON:0002187 ! terminal bronchiole [Term] id: UBERON:0004517 name: smooth muscle tissue of respiratory bronchiole def: "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]." [] is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002188 ! respiratory bronchiole relationship: part_of UBERON:0002188 ! respiratory bronchiole [Term] id: UBERON:0004520 name: striated muscle tissue of prostate def: "A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition]." [] is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:0008715 ! muscle tissue of prostate intersection_of: UBERON:0002036 ! striated muscle tissue intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0004521 name: vasculature of muscle organ def: "A vasculature that is part of a muscle organ [Automatically generated definition]." [] synonym: "muscular organ vasculature" EXACT [] is_a: UBERON:0004522 ! vasculature of musculoskeletal system is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001630 ! muscle organ relationship: part_of UBERON:0001630 ! muscle organ [Term] id: UBERON:0004522 name: vasculature of musculoskeletal system def: "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." [] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002204 ! musculoskeletal system relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] id: UBERON:0004535 name: cardiovascular system def: "Anatomical system that has as its parts the heart and blood vessels." [] synonym: "CV system" RELATED [] synonym: "Herz und Gefaesssystem" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0001009 ! circulatory system [Term] id: UBERON:0004536 name: lymph vasculature def: "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." [] synonym: "lymphatic trunks and ducts" EXACT [] synonym: "lymphatic vasculature" EXACT [] synonym: "lymphatic vessel network" EXACT [] synonym: "lymphatic vessels set" EXACT [] synonym: "set of lymphatic vessels" EXACT [] synonym: "trunci et ductus lymphatici" EXACT [] is_a: UBERON:0002049 ! vasculature relationship: part_of UBERON:0002465 ! lymphoid system [Term] id: UBERON:0004537 name: blood vasculature def: "a vascular network consisting of blood vessels." [] synonym: "blood vascular network" EXACT [] synonym: "blood vessels" RELATED [] synonym: "set of blood vessels" EXACT [] is_a: UBERON:0002049 ! vasculature relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0004544 name: epididymis epithelium def: "A simple columnar epithelium that is part of a epididymis [Automatically generated definition]." [] synonym: "Epididymis epithelium" EXACT [] synonym: "epithelium of epididymis" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000485 ! simple columnar epithelium intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] id: UBERON:0004550 name: gastroesophageal sphincter def: "A sphincter muscle that is part of a cardia of stomach [Automatically generated definition]." [] synonym: "cardiac sphincter" RELATED [] synonym: "esophageal sphincter" RELATED [] synonym: "esophageal sphincter%2c lower" RELATED [] synonym: "esophageal-cardiac junction" RELATED [] synonym: "esophagogastric junction" RELATED [] synonym: "gastro-esophageal junction" RELATED [] synonym: "gastro-esophageal sphincter" RELATED [] synonym: "gastro-oesophageal junction" RELATED [] synonym: "gastroesophageal junction" RELATED [] synonym: "gastroesophageal sphincter" EXACT [] synonym: "gastroesophageal sphincter" RELATED [] synonym: "gastroesophageal sphincter muscle" EXACT [] synonym: "inferior esophageal sphincter" EXACT [] synonym: "LES" RELATED [] synonym: "lower esophageal sphincter" RELATED [] is_a: UBERON:0011185 ! gastrointestinal sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0001162 ! cardia of stomach [Term] id: UBERON:0004571 name: systemic arterial system def: "the part of the cardiovascular system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." [] synonym: "systemic arterial circulatory system" EXACT [] is_a: UBERON:0007798 ! vascular system relationship: part_of UBERON:0004572 ! arterial system [Term] id: UBERON:0004572 name: arterial system def: "The part of the cardiovascular system consisting of all arteries." [] is_a: UBERON:0007798 ! vascular system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0004573 name: systemic artery def: "Systemic arteries are the arteries of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." [] synonym: "systemic arterial subtree" EXACT [] is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0004571 ! systemic arterial system relationship: part_of UBERON:0004571 ! systemic arterial system [Term] id: UBERON:0004581 name: systemic venous system def: "The part of the venous system that drains the general body tissues[Kardong]" [] synonym: "systemic venous circulatory system" EXACT [] is_a: UBERON:0002049 ! vasculature relationship: part_of UBERON:0004582 ! venous system [Term] id: UBERON:0004582 name: venous system def: "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." [] synonym: "vein system" EXACT [] is_a: UBERON:0007798 ! vascular system [Term] id: UBERON:0004590 name: sphincter muscle def: "a structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [] synonym: "circular muscle" RELATED [] synonym: "sphincter" EXACT [] is_a: UBERON:0001630 ! muscle organ [Term] id: UBERON:0004638 name: blood vessel endothelium def: "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart" [] is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel [Term] id: UBERON:0004639 name: afferent arteriole def: "The afferent arterioles are a group of blood vessels that supply the nephrons in many excretory systems. They play an important role in the regulation of blood pressure. The afferent arterioles branch from the renal artery which supplies blood to the kidneys. The afferent arterioles later diverge into the capillaries of the glomerulus. When renal blood flow is reduced, the macula densa releases prostaglandins, which cause the juxtaglomerular cells lining the afferent arterioles to release renin, activating the renin-angiotensin-aldosterone system, to increase blood pressure. [WP,unvetted]." [] synonym: "afferent glomerular arteriole" EXACT [] synonym: "arteriola glomerularis afferens" RELATED [] synonym: "kidney afferent arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001229 ! renal corpuscle [Term] id: UBERON:0004640 name: efferent arteriole def: "The efferent arterioles are blood vessels that are part of the urinary tract of organisms. The efferent arterioles form from a convergence of the capillaries of the glomerulus. They play an important role in maintaining the glomerular filtration rate despite fluctuations in blood pressure. In the mammalian kidney they follow two markedly different courses, depending on the location of the glomeruli from which they arise. In the mammalian kidney about 15% of glomeruli lie close to the boundary between the renal cortex and renal medulla and are known as juxtamedullary glomeruli. The rest are simply undifferentiated cortical glomeruli. [WP,unvetted]." [] synonym: "arteriola glomerularis efferens capsulae renalis" RELATED [] synonym: "efferent glomerular arteriole" EXACT [] synonym: "kidney efferent arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001229 ! renal corpuscle [Term] id: UBERON:0004641 name: spleen capsule def: "A capsule that is part of a spleen [Automatically generated definition]." [] synonym: "capsule of spleen" EXACT [] synonym: "fibroelastic coat of spleen" EXACT [] synonym: "fibrous capsule of spleen" EXACT [] synonym: "Malpighian capsule" EXACT [] synonym: "splenic capsule" EXACT [] synonym: "tunica fibrosa (splen)(lien)" EXACT [] is_a: UBERON:0003893 ! capsule is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003893 ! capsule intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004643 name: lateral ventricle ependyma def: "An ependyma that is part of a lateral ventricle [Automatically generated definition]." [] synonym: "ependyma of lateral ventricle" EXACT [] is_a: UBERON:0005357 ! brain ependyma is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0004670 ! ependyma intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: UBERON:0004644 name: fourth ventricle ependyma def: "An ependyma that is part of a fourth ventricle [Automatically generated definition]." [] synonym: "4th ventricle ependyma" RELATED [] synonym: "ependyma of fourth ventricle" EXACT [] is_a: UBERON:0005357 ! brain ependyma intersection_of: UBERON:0004670 ! ependyma intersection_of: part_of UBERON:0002422 ! fourth ventricle relationship: part_of UBERON:0002422 ! fourth ventricle [Term] id: UBERON:0004645 name: urinary bladder urothelium def: "The epithelial lining of the luminal space of the urinary bladder." [] synonym: "bladder transitional cell epithelium" EXACT [] synonym: "transitional epithelium" RELATED [] synonym: "transitional epithelium of urinary bladder" EXACT [] synonym: "urinary bladder transitional epithelium" EXACT [] synonym: "urothelium" BROAD [] synonym: "urothelium of urinary bladder" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000365 ! urothelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000365 ! urothelium intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001259 ! mucosa of urinary bladder [Term] id: UBERON:0004647 name: liver lobule def: "a small division of the liver defined at the histological scale, the functional unit of which is the hepatic acinus." [] synonym: "hepatic lobule" EXACT [] synonym: "lobules of liver" RELATED [] synonym: "lobuli hepatici" EXACT [] synonym: "lobuli hepatis" RELATED [] synonym: "lobulus hepaticus" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0001280 ! liver parenchyma [Term] id: UBERON:0004663 name: aorta wall def: "An anatomical wall that is part of an aorta [Automatically generated definition]." [] synonym: "Aortic wall" EXACT [] synonym: "wall of aorta" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0004664 name: aorta tunica adventitia def: "A tunica adventitia that is part of a aorta." [] synonym: "tunica adventitia of aorta" EXACT [] is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0004663 ! aorta wall [Term] id: UBERON:0004665 name: seminal vesicle muscle layer def: "A portion of muscle tissue that is part of a seminal vesicle [Automatically generated definition]." [] synonym: "muscle layer of seminal vesicle" EXACT [] synonym: "muscular coat of seminal gland" EXACT [] synonym: "muscular layer of seminal gland" EXACT [] synonym: "tunica muscularis (Vesicula seminalis)" EXACT [] synonym: "tunica muscularis glandulae vesiculosae" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscle layer is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle [Term] id: UBERON:0004666 name: interventricular septum membranous part def: "The membranous portion of the wall between the two lower chambers of the heart" [] synonym: "cardiac ventricular membranous septum" EXACT [] synonym: "membranous interventricular septum" EXACT [] synonym: "membranous interventricular septum" RELATED [] synonym: "membranous part interventricular septum" EXACT [] synonym: "membranous part of interventricular septum" EXACT [] synonym: "membranous portion of interventricular septum" EXACT [] synonym: "membranous septum" BROAD [] synonym: "pars membranacea (septi interventricularis)" EXACT [] synonym: "ventricular membranous septum" BROAD [] is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005983 ! heart layer is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000158 ! membranous layer intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: develops_from UBERON:0000095 ! cardiac neural crest relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: UBERON:0004667 name: interventricular septum muscular part def: "The muscular portion of the wall between the two lower chambers of the heart" [] synonym: "cardiac ventricular muscular septum" EXACT [] synonym: "muscular interventricular septum" EXACT [] synonym: "muscular interventricular septum" RELATED [] synonym: "muscular part interventricular septum" EXACT [] synonym: "muscular part of interventricular septum" EXACT [] synonym: "muscular septum" BROAD [] synonym: "pars muscularis (septi interventricularis)" EXACT [] synonym: "septum membranaceum" EXACT [] synonym: "ventricular muscular septum" EXACT [] is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: UBERON:0004670 name: ependyma def: "the thin epithelial membrane lining the ventricular system of the brain and the spinal cord. Ependyma is one of the four types of neuroglia in the central nervous system. It is involved in the production of cerebrospinal fluid (CSF). It is simple, columnar or cuboidal." [] synonym: "ependyma of neuraxis" EXACT [] synonym: "ependymal epithelium" EXACT [] synonym: "lamina epithelialis" RELATED [] is_a: UBERON:0007601 ! ciliated epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0005358 ! ventricle of nervous system relationship: part_of UBERON:0005358 ! ventricle of nervous system [Term] id: UBERON:0004681 name: vestibular system def: "The sensory system for the sense of balance." [] synonym: "equilibrioception system" NARROW [] synonym: "vestibular organ system" EXACT [] synonym: "vestibular system" EXACT [] synonym: "vestibulomotor system" NARROW [] is_a: UBERON:0001032 ! sensory system [Term] id: UBERON:0004684 name: raphe nuclei def: "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." [] synonym: "nuclei raphes" EXACT [] synonym: "nuclei raphes" RELATED [] synonym: "raphe cluster" RELATED [] synonym: "raphe nuclei" EXACT [] synonym: "raphe nuclei set" EXACT [] synonym: "raphe nucleus" RELATED [] synonym: "Raphe of mesenchephalon" RELATED [] synonym: "set of raphe nuclei" RELATED [] is_a: UBERON:0000073 ! regional part of nervous system relationship: part_of UBERON:0002275 ! reticular formation [Term] id: UBERON:0004693 name: Peyer's patch epithelium def: "An epithelium that is part of a Peyer' s patch [Automatically generated definition]." [] synonym: "peyer's patch epithelium" EXACT [] is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0004695 name: arterial system smooth muscle def: "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." [] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0004572 ! arterial system relationship: part_of UBERON:0004572 ! arterial system [Term] id: UBERON:0004696 name: venous system smooth muscle def: "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." [] is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0004582 ! venous system relationship: part_of UBERON:0004237 ! blood vessel smooth muscle relationship: part_of UBERON:0004582 ! venous system [Term] id: UBERON:0004699 name: outflow tract endothelium def: "An endothelium that is part of a outflow tract [Automatically generated definition]." [] is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004700 name: arterial system endothelium def: "An endothelium that is part of an arterial system [Automatically generated definition]." [] is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0004572 ! arterial system relationship: part_of UBERON:0004572 ! arterial system [Term] id: UBERON:0004701 name: venous system endothelium def: "An endothelium that is part of a venous system [Automatically generated definition]." [] is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0004582 ! venous system relationship: part_of UBERON:0004582 ! venous system [Term] id: UBERON:0004702 name: respiratory system blood vessel endothelium def: "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." [] is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0004638 ! blood vessel endothelium intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003504 ! respiratory system blood vessel [Term] id: UBERON:0004706 name: bulbus cordis def: "The bulbus cordis lies ventral to the primitive ventricle after the developing heart assumes its S-shaped form. Together, the bulbus cordis and the primitive ventricle give rise to the ventricle of the formed heart. The adjacent walls of the bulbus cordis and ventricle approximate, fuse, and finally disappear, and the bulbus cordis now communicates freely with the right ventricle, while the junction of the bulbus with the truncus arteriosus is brought directly ventral to and applied to the atrial canal. By the upgrowth of the ventricular septum the bulbus cordis is in great measure separated from the left ventricle, but remains an integral part of the right ventricle, of which it forms the infundibulum[WP]." [] synonym: "primitive right ventricle endocardium" EXACT [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0004715 name: annulus fibrosus disci intervertebralis def: "The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised." [] synonym: "annulus fibrosus" BROAD [] synonym: "annulus fibrosus of intervertebral disc" RELATED [] synonym: "anulus fibrosus (diskus intervertebralis)" EXACT [] synonym: "anulus fibrosus of intervertebral disk" EXACT [] synonym: "fibrous ring of intervertebral disc" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006444 ! annulus fibrosus intersection_of: UBERON:0006444 ! annulus fibrosus intersection_of: part_of UBERON:0001066 ! intervertebral disk relationship: part_of UBERON:0001066 ! intervertebral disk [Term] id: UBERON:0004716 name: conceptus def: "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." [] synonym: "embryo plus adnexa" EXACT [] is_a: UBERON:0000480 ! anatomical group [Term] id: UBERON:0004719 name: arcuate vein def: "The arcuate vein is a vessel of the renal circulation. It is located at the border of the renal cortex and renal medulla." [] synonym: "arcuate veins" RELATED [] synonym: "venae arcuatae renis" RELATED [] is_a: UBERON:0003517 ! kidney blood vessel [Term] id: UBERON:0004721 name: crista ampullaris def: "The crista ampullaris is the sensory organ of rotation located in the semicircular canal of the inner ear. The function of the crista ampullaris is to sense angular acceleration and deceleration." [] synonym: "ampullary crest" RELATED [] synonym: "ampullary crest of semicircular duct" EXACT [] synonym: "cristae ampullares" RELATED [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0004043 ! semicircular canal ampulla [Term] id: UBERON:0004723 name: interlobular artery def: "the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule." [] synonym: "arteriae corticales radiatae" RELATED [] synonym: "arteriae interlobulares renis" RELATED [] synonym: "cortical radial arteries" RELATED [] synonym: "interlobular" RELATED [] synonym: "interlobular renal artery" EXACT [] synonym: "kidney interlobular artery" EXACT [] is_a: UBERON:0003644 ! kidney arterial blood vessel [Term] id: UBERON:0004726 name: vasa recta def: "In the blood supply of the kidney, the vasa recta renis (or straight arteries of kidney, or straight arterioles of kidney) form a series of straight capillaries in the medulla. They lie parallel to the loop of Henle. These vessels branch off the efferent arterioles of juxtamedullary nephrons (those nephrons closest to the medulla), enter the medulla, and surround the loop of Henle." [] synonym: "arteria recta" RELATED [] synonym: "arteriae rectae" RELATED [] synonym: "arteriolae rectae renis" EXACT [] synonym: "arteriolae rectae renis" RELATED [] synonym: "arteriolae recti" RELATED [] synonym: "kidney vasa recta" EXACT [] synonym: "renal medullary capillary" EXACT [] synonym: "set of straight arterioles of kidney" EXACT [] synonym: "straight arterioles of kidney" EXACT [] synonym: "vasa recta of kidney" EXACT [] synonym: "vasa recta renis" EXACT [] synonym: "vasa rectae" RELATED [] is_a: UBERON:0001140 ! renal vein [Term] id: UBERON:0004731 name: neuromere def: "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." [] synonym: "neural metamere" RELATED [] synonym: "neural segment" RELATED [] synonym: "neural tube metameric segment" EXACT [] synonym: "neural tube segment" EXACT [] synonym: "neuromere" EXACT [] synonym: "neuromeres" EXACT [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: part_of UBERON:0001049 ! neural tube relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0004732 name: segmental subdivision of nervous system def: "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." [] synonym: "neuromere" RELATED [] is_a: UBERON:0000063 ! organ segment intersection_of: UBERON:0000063 ! organ segment intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0004733 name: segmental subdivision of hindbrain def: "An organ segment that is part of a hindbrain [Automatically generated definition]." [] synonym: "hindbrain segment" EXACT [] synonym: "segment of hindbrain" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0000063 ! organ segment intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0004734 name: gastrula def: "Organism at the gastrula stage." [] synonym: "blastocystis trilaminaris" RELATED [] synonym: "gastrula embryo" EXACT [] synonym: "tri-laminar disc" RELATED [] synonym: "tri-laminar disk" RELATED [] synonym: "trilaminar blastocyst" RELATED [] synonym: "trilaminar blastoderm" RELATED [] synonym: "trilaminar disc" RELATED [] synonym: "trilaminar disk" RELATED [] synonym: "trilaminar germ" RELATED [] is_a: UBERON:0000922 ! embryo relationship: develops_from UBERON:0000307 ! blastula [Term] id: UBERON:0004736 name: metanephric glomerulus def: "glomerulus of the mature vertebrate kidney, or metanephros." [] synonym: "glomerulus of metanephros" EXACT [] is_a: UBERON:0000074 ! renal glomerulus intersection_of: UBERON:0000074 ! renal glomerulus intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0004737 name: metanephric collecting duct def: "A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition]." [] synonym: "collecting duct of metanephros" EXACT [] synonym: "metanephric collecting tubule" RELATED [] is_a: UBERON:0001232 ! collecting duct of renal tubule is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: develops_from UBERON:0014706 ! primitive renal collecting duct system relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0004738 name: metanephric juxtaglomerular apparatus def: "juxtaglomerular apparatus of the mature vertebrate kidney, or metanephros." [] synonym: "juxtaglomerular apparatus of metanephros" EXACT [] is_a: UBERON:0002303 ! juxtaglomerular apparatus is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002303 ! juxtaglomerular apparatus intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0010533 ! metanephros cortex [Term] id: UBERON:0004739 name: pronephric glomerulus def: "The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [] synonym: "corpuscle" RELATED [] synonym: "glomera" RELATED [] synonym: "glomerulus of pronephros" EXACT [] synonym: "glomus" NARROW [] synonym: "pronephric glomera" RELATED [] synonym: "pronephric glomeruli" RELATED [] synonym: "pronephric glomus" RELATED [] is_a: UBERON:0000074 ! renal glomerulus intersection_of: UBERON:0000074 ! renal glomerulus intersection_of: part_of UBERON:0002120 ! pronephros relationship: develops_from UBERON:0007128 ! glomeral mesenchyme relationship: part_of UBERON:0002120 ! pronephros [Term] id: UBERON:0004755 name: skeletal tissue def: "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]" [] synonym: "mineralized tissue" NARROW [] is_a: UBERON:0002384 ! connective tissue relationship: part_of UBERON:0004765 ! skeletal element [Term] id: UBERON:0004756 name: dermal skeletal element def: "dermis-derived entity that is made of skeletal tissue." [] synonym: "dermal element" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004765 ! skeletal element is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0002067 ! dermis [Term] id: UBERON:0004760 name: gland of anal canal def: "A gland that is part of an anal canal [Automatically generated definition]." [] synonym: "anal gland" RELATED [] synonym: "anal sac" RELATED [] synonym: "gland of anal canal" EXACT [] synonym: "gland of anus" RELATED [] synonym: "rectal gland" RELATED [] is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal [Term] id: UBERON:0004761 name: cartilaginous neurocranium def: "the primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." [] synonym: "cartilaginous chondocranium" EXACT [] synonym: "cartilaginous skull" RELATED [] synonym: "cartiligionous skeletal structure of skull" EXACT [] synonym: "chondocranium" RELATED [] synonym: "embryonic chondocranium" RELATED [] synonym: "neurocranium" RELATED [] is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0009617 ! head paraxial mesoderm [Term] id: UBERON:0004765 name: skeletal element def: "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." [] is_a: UBERON:0000062 ! organ relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0004766 name: cranial bone def: "A bone that is part of a cranium." [] synonym: "cranium bone" EXACT [] is_a: UBERON:0003457 ! head bone intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0003128 ! cranium relationship: part_of UBERON:0003128 ! cranium [Term] id: UBERON:0004770 name: articular system def: "Anatomical system that consists of all the joints of the body." [] synonym: "joint system" EXACT [] synonym: "set of all joints" RELATED [] synonym: "set of all joints of body" EXACT [] synonym: "set of joints of body" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0004775 name: outer renal medulla vasa recta def: "A vasa recta that is part of a outer medulla of kidney [Automatically generated definition]." [] synonym: "kidney outer medulla vasa recta" EXACT [] synonym: "kidney outer renal medulla vasa recta" EXACT [] synonym: "outer medulla of kidney vasa recta" EXACT [] synonym: "outer zone of medulla of kidney vasa recta" EXACT [] synonym: "outer zone of renal medulla vasa recta" EXACT [] synonym: "vasa recta of outer medulla of kidney" EXACT [] synonym: "vasa recta of outer renal medulla" EXACT [] synonym: "vasa recta of outer zone of medulla of kidney" EXACT [] synonym: "vasa recta of outer zone of renal medulla" EXACT [] is_a: UBERON:0004726 ! vasa recta is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel intersection_of: UBERON:0004726 ! vasa recta intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: UBERON:0004776 name: inner renal medulla vasa recta def: "A vasa recta that is part of a inner medulla of kidney [Automatically generated definition]." [] synonym: "inner medulla of kidney vasa recta" EXACT [] synonym: "inner zone of medulla of kidney vasa recta" EXACT [] synonym: "inner zone of renal medulla vasa recta" EXACT [] synonym: "set of inner region of renal pyramids vasa recta" EXACT [] synonym: "vasa recta of inner medulla of kidney" EXACT [] synonym: "vasa recta of inner renal medulla" EXACT [] synonym: "vasa recta of inner zone of medulla of kidney" EXACT [] synonym: "vasa recta of inner zone of renal medulla" EXACT [] synonym: "vasa recta of set of inner region of renal pyramids" EXACT [] is_a: UBERON:0004726 ! vasa recta is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel intersection_of: UBERON:0004726 ! vasa recta intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: UBERON:0004777 name: respiratory system submucosa def: "A submucosa that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius submucosa" EXACT [] synonym: "submucosa of apparatus respiratorius" EXACT [] synonym: "submucosa of respiratory system" EXACT [] is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003570 ! respiratory system connective tissue [Term] id: UBERON:0004779 name: respiratory system lamina propria def: "A lamina propria that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius lamina propria" EXACT [] synonym: "apparatus respiratorius lamina propria mucosa" EXACT [] synonym: "lamina propria mucosa of apparatus respiratorius" EXACT [] synonym: "lamina propria mucosa of respiratory system" EXACT [] synonym: "lamina propria of apparatus respiratorius" EXACT [] synonym: "lamina propria of respiratory system" EXACT [] synonym: "respiratory system lamina propria mucosa" EXACT [] is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003570 ! respiratory system connective tissue relationship: part_of UBERON:0004785 ! respiratory system mucosa [Term] id: UBERON:0004780 name: gastrointestinal system lamina propria def: "A lamina propria that is part of a gastrointestinal system." [] is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004781 name: gall bladder lamina propria def: "A lamina propria that is part of a gallbladder [Automatically generated definition]." [] synonym: "biliary lamina propria" RELATED [] synonym: "gall bladder lamina propria mucosa" EXACT [] synonym: "gallbladder lamina propria" EXACT [] synonym: "gallbladder lamina propria mucosa" EXACT [] synonym: "lamina propria mucosa of gall bladder" EXACT [] synonym: "lamina propria mucosa of gallbladder" EXACT [] synonym: "lamina propria of gall bladder" EXACT [] synonym: "lamina propria of gallbladder" EXACT [] is_a: UBERON:0000030 ! lamina propria is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0005033 ! mucosa of gallbladder [Term] id: UBERON:0004782 name: gastrointestinal system serosa def: "A serous membrane that is part of a digestive system [Automatically generated definition]." [] synonym: "digestive system serosa" EXACT [] synonym: "digestive system serous membrane" EXACT [] synonym: "gastrointestinal system serous membrane" EXACT [] synonym: "serosa of digestive system" EXACT [] synonym: "serosa of gastrointestinal system" EXACT [] synonym: "serous membrane of digestive system" EXACT [] synonym: "serous membrane of gastrointestinal system" EXACT [] is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004783 name: gall bladder serosa def: "A serous membrane that is part of a gallbladder [Automatically generated definition]." [] synonym: "biliary serosa" RELATED [] synonym: "gall bladder serous membrane" EXACT [] synonym: "gallbladder serosa" EXACT [] synonym: "gallbladder serous membrane" EXACT [] synonym: "serosa of gall bladder" EXACT [] synonym: "serosa of gallbladder" EXACT [] synonym: "serous coat of gallbladder" EXACT [] synonym: "serous membrane of gall bladder" EXACT [] synonym: "serous membrane of gallbladder" EXACT [] synonym: "tunica serosa (vesica biliaris)" EXACT [] synonym: "tunica serosa vesicae biliaris" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: UBERON:0004784 name: heart ventricle wall def: "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." [] synonym: "anatomical wall of cardiac ventricle" EXACT [] synonym: "anatomical wall of heart ventricle" EXACT [] synonym: "anatomical wall of lower chamber of heart" EXACT [] synonym: "anatomical wall of ventricle of heart" EXACT [] synonym: "cardiac ventricle anatomical wall" EXACT [] synonym: "cardiac ventricle wall" EXACT [] synonym: "heart ventricle anatomical wall" EXACT [] synonym: "lower chamber of heart anatomical wall" EXACT [] synonym: "lower chamber of heart wall" EXACT [] synonym: "ventricle of heart anatomical wall" EXACT [] synonym: "ventricle of heart wall" EXACT [] synonym: "ventricular wall" EXACT [] synonym: "wall of cardiac ventricle" EXACT [] synonym: "wall of heart ventricle" EXACT [] synonym: "wall of lower chamber of heart" EXACT [] synonym: "wall of ventricle" RELATED [] synonym: "wall of ventricle of heart" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0004785 name: respiratory system mucosa def: "A mucosa that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius mucosa" EXACT [] synonym: "apparatus respiratorius mucosa of organ" EXACT [] synonym: "apparatus respiratorius mucous membrane" EXACT [] synonym: "mucosa of apparatus respiratorius" EXACT [] synonym: "mucosa of organ of apparatus respiratorius" EXACT [] synonym: "mucosa of organ of respiratory system" EXACT [] synonym: "mucosa of respiratory system" EXACT [] synonym: "mucous membrane of apparatus respiratorius" EXACT [] synonym: "mucous membrane of respiratory system" EXACT [] synonym: "respiratory mucosa" RELATED [] synonym: "respiratory system mucosa of organ" EXACT [] synonym: "respiratory system mucous membrane" EXACT [] synonym: "respiratory tract mucosa" RELATED [] is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0004786 name: gastrointestinal system mucosa def: "A mucosa that is part of a gastrointestinal system." [] synonym: "digestive tract mucosa" EXACT [] synonym: "gut mucosa" EXACT [] synonym: "gut mucuous membrane" EXACT [] synonym: "mucosa of gut" EXACT [] is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004787 name: urethra urothelium def: "An urothelium that is part of a urethra [Automatically generated definition]." [] synonym: "urethra Uroepithelium" EXACT [] synonym: "uroepithelium of urethra" EXACT [] synonym: "urothelium of urethra" EXACT [] is_a: UBERON:0000365 ! urothelium is_a: UBERON:0002325 ! epithelium of urethra intersection_of: UBERON:0000365 ! urothelium intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: UBERON:0004788 name: kidney pelvis urothelium def: "An urothelium that is part of a renal pelvis [Automatically generated definition]." [] synonym: "kidney pelvis transitional epithelium" EXACT [] synonym: "kidney pelvis Uroepithelium" EXACT [] synonym: "pelvis of ureter Uroepithelium" EXACT [] synonym: "pelvis of ureter urothelium" EXACT [] synonym: "renal pelvis transitional epithelium" EXACT [] synonym: "renal pelvis Uroepithelium" EXACT [] synonym: "renal pelvis urothelium" EXACT [] synonym: "transitional epithelium of kidney pelvis" EXACT [] synonym: "transitional epithelium of renal pelvis" EXACT [] synonym: "uroepithelium of kidney pelvis" EXACT [] synonym: "uroepithelium of pelvis of ureter" EXACT [] synonym: "uroepithelium of renal pelvis" EXACT [] synonym: "urothelium of kidney pelvis" EXACT [] synonym: "urothelium of pelvis of ureter" EXACT [] synonym: "urothelium of renal pelvis" EXACT [] is_a: UBERON:0001254 ! urothelium of ureter is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0000365 ! urothelium intersection_of: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis [Term] id: UBERON:0004790 name: skin mucous gland def: "A mucous gland that is part of a skin of body." [] synonym: "mucous gland of entire skin" EXACT [] synonym: "mucous gland of skin of body" EXACT [] synonym: "skin mucus gland" EXACT [] synonym: "skin of body mucous gland" EXACT [] is_a: UBERON:0000414 ! mucous gland is_a: UBERON:0002419 ! skin gland intersection_of: UBERON:0000414 ! mucous gland intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body [Term] id: UBERON:0004797 name: blood vessel layer def: "An organ component layer that is part of a blood vessel." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel [Term] id: UBERON:0004801 name: cervix epithelium def: "An epithelium that is part of a uterine cervix [Automatically generated definition]." [] synonym: "cervical canal epithelial tissue" EXACT [] synonym: "cervical canal epithelium" EXACT [] synonym: "cervical epithelium" EXACT [] synonym: "cervix epithelial tissue" EXACT [] synonym: "epithelium of cervix" EXACT [] is_a: UBERON:0006955 ! uterine epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix [Term] id: UBERON:0004802 name: respiratory tract epithelium def: "An epithelium that is part of a respiratory tract [Automatically generated definition]." [] synonym: "airway epithelium" RELATED [] synonym: "epithelial tissue of respiratory tract" EXACT [] synonym: "epithelium of respiratory tract" EXACT [] synonym: "respiratory epithelium" RELATED [] synonym: "respiratory tract epithelial tissue" EXACT [] is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000072 ! segment of respiratory tract [Term] id: UBERON:0004803 name: penis epithelium def: "An epithelium that is part of a penis [Automatically generated definition]." [] synonym: "epithelial tissue of penis" EXACT [] synonym: "epithelium of penis" EXACT [] synonym: "penis epithelial tissue" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000989 ! penis relationship: part_of UBERON:0000989 ! penis [Term] id: UBERON:0004804 name: oviduct epithelium def: "An epithelium that is part of a oviduct [Automatically generated definition]." [] synonym: "epithelial tissue of oviduct" EXACT [] synonym: "epithelium of fallopian tube" EXACT [] synonym: "epithelium of oviduct" EXACT [] synonym: "epithelium of uterine tube" EXACT [] synonym: "oviduct epithelial tissue" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0003889 ! fallopian tube [Term] id: UBERON:0004805 name: seminal vesicle epithelium def: "An epithelium that is part of a seminal vesicle [Automatically generated definition]." [] synonym: "epithelial tissue of seminal gland" EXACT [] synonym: "epithelial tissue of seminal vesicle" EXACT [] synonym: "epithelium of seminal gland" EXACT [] synonym: "epithelium of seminal vesicle" EXACT [] synonym: "seminal gland epithelial tissue" EXACT [] synonym: "seminal gland epithelium" EXACT [] synonym: "seminal vesicle epithelial tissue" EXACT [] is_a: UBERON:0004910 ! epithelium of male gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle [Term] id: UBERON:0004807 name: respiratory system epithelium def: "An epithelium that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius epithelial tissue" EXACT [] synonym: "apparatus respiratorius epithelium" EXACT [] synonym: "epithelial tissue of apparatus respiratorius" EXACT [] synonym: "epithelial tissue of respiratory system" EXACT [] synonym: "epithelium of apparatus respiratorius" EXACT [] synonym: "epithelium of respiratory system" EXACT [] synonym: "respiratory system epithelial tissue" EXACT [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0004808 name: gastrointestinal system epithelium def: "An epithelium that is part of a digestive system [Automatically generated definition]." [] synonym: "digestive system epithelial tissue" EXACT [] synonym: "digestive system epithelium" EXACT [] synonym: "epithelial tissue of digestive system" EXACT [] synonym: "epithelial tissue of gastrointestinal system" EXACT [] synonym: "epithelium of digestive system" EXACT [] synonym: "epithelium of gastrointestinal system" EXACT [] synonym: "gastrointestinal system epithelial tissue" EXACT [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004809 name: salivary gland epithelium def: "An epithelium that is part of a salivary gland [Automatically generated definition]." [] synonym: "epithelial tissue of salivary gland" EXACT [] synonym: "epithelium of salivary gland" EXACT [] synonym: "salivary gland epithelial tissue" EXACT [] is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001044 ! salivary gland relationship: develops_from UBERON:0011272 ! embryonic skin basal layer relationship: part_of UBERON:0001044 ! salivary gland [Term] id: UBERON:0004810 name: nephron tubule epithelium def: "An epithelium that is part of a nephron tubule [Automatically generated definition]." [] synonym: "epithelial tissue of nephron tubule" EXACT [] synonym: "epithelial tissue of renal tubule" EXACT [] synonym: "epithelial tissue of tubulus renalis" EXACT [] synonym: "epithelium of nephron tubule" EXACT [] synonym: "epithelium of renal tubule" EXACT [] synonym: "epithelium of tubulus renalis" EXACT [] synonym: "kidney tubule epithelium" EXACT [] synonym: "nephron tubule epithelial tissue" EXACT [] synonym: "nephron tubule epithelium" EXACT [] synonym: "renal tubule epithelial tissue" EXACT [] synonym: "tubulus renalis epithelial tissue" EXACT [] synonym: "tubulus renalis epithelium" EXACT [] is_a: UBERON:0004211 ! nephron epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0001231 ! nephron tubule [Term] id: UBERON:0004811 name: endometrium epithelium def: "An epithelium that is part of a endometrium [Automatically generated definition]." [] synonym: "endometrium epithelial tissue" EXACT [] synonym: "epithelial tissue of endometrium" EXACT [] synonym: "epithelium of endometrium" EXACT [] synonym: "epithelium of tunica mucosa (endometrium)" EXACT [] synonym: "uterine epithelium" RELATED [] is_a: UBERON:0006955 ! uterine epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium [Term] id: UBERON:0004812 name: male prepuce epithelium def: "An epithelium that is part of a prepuce of penis [Automatically generated definition]." [] synonym: "epithelial tissue of foreskin" EXACT [] synonym: "epithelial tissue of penile prepuce" EXACT [] synonym: "epithelial tissue of prepuce" BROAD [] synonym: "epithelial tissue of prepuce of penis" EXACT [] synonym: "epithelium of foreskin" EXACT [] synonym: "epithelium of penile prepuce" EXACT [] synonym: "epithelium of prepuce" BROAD [] synonym: "epithelium of prepuce of penis" EXACT [] synonym: "foreskin epithelial tissue" EXACT [] synonym: "foreskin epithelium" EXACT [] synonym: "penile prepuce epithelial tissue" EXACT [] synonym: "penile prepuce epithelium" EXACT [] synonym: "prepuce epithelial tissue" BROAD [] synonym: "prepuce epithelium" EXACT [] synonym: "prepuce of penis epithelial tissue" EXACT [] synonym: "prepuce of penis epithelium" BROAD [] is_a: UBERON:0004803 ! penis epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001332 ! prepuce of penis relationship: part_of UBERON:0001332 ! prepuce of penis [Term] id: UBERON:0004813 name: seminiferous tubule epithelium def: "The epithelium lining the seminiferous tubules composed of primary male germ cells (spermatogonia) and supporting sertoli cells. As spermatogenesis proceeds, the developing germ cells migrate toward the lumen. The adluminal compartment, the inner two thirds of the tubules, contains spermatocytes and the more advanced germ cells[GAID]." [] synonym: "epithelial tissue of seminiferous tubule" EXACT [] synonym: "epithelial tissue of seminiferous tubule of testis" EXACT [] synonym: "epithelium of seminiferous tubule" EXACT [] synonym: "epithelium of seminiferous tubule of testis" EXACT [] synonym: "germinal epithelium (male)" EXACT [] synonym: "male germinal epithelium" EXACT [] synonym: "seminiferous epithelium" EXACT [] synonym: "seminiferous tubule epithelial tissue" EXACT [] synonym: "testis germinal epithelium" EXACT [] synonym: "wall of seminiferous tubule" EXACT [] is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004910 ! epithelium of male gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis [Term] id: UBERON:0004814 name: upper respiratory tract epithelium def: "An epithelium that is part of a upper respiratory tract [Automatically generated definition]." [] synonym: "epithelial tissue of upper respiratory tract" EXACT [] synonym: "epithelium of upper respiratory tract" EXACT [] synonym: "upper respiratory tract epithelial tissue" EXACT [] is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001557 ! upper respiratory tract relationship: part_of UBERON:0001557 ! upper respiratory tract [Term] id: UBERON:0004815 name: lower respiratory tract epithelium def: "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." [] synonym: "epithelial tissue of lower respiratory tract" EXACT [] synonym: "epithelium of lower respiratory tract" EXACT [] synonym: "lower respiratory tract epithelial tissue" EXACT [] is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0004819 name: kidney epithelium def: "An epithelium that is part of a kidney [Automatically generated definition]." [] synonym: "epithelial tissue of kidney" EXACT [] synonym: "epithelium of kidney" EXACT [] synonym: "kidney epithelial tissue" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0004820 name: bile duct epithelium def: "Epithelium of the gallbladder and the intrahepatic and extrahepatic bile ducts." [] synonym: "bile duct epithelial tissue" EXACT [] synonym: "biliary duct epithelial tissue" EXACT [] synonym: "biliary duct epithelium" EXACT [] synonym: "biliary epithelium" EXACT [] synonym: "epithelial tissue of bile duct" EXACT [] synonym: "epithelial tissue of biliary duct" EXACT [] synonym: "epithelium of bile duct" EXACT [] synonym: "epithelium of biliary duct" EXACT [] is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002394 ! bile duct relationship: part_of UBERON:0002394 ! bile duct [Term] id: UBERON:0004821 name: pulmonary alveolus epithelium def: "the epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." [] synonym: "alveolus epithelial tissue" EXACT [] synonym: "alveolus epithelium" EXACT [] synonym: "epithelial tissue of alveolus" EXACT [] synonym: "epithelium of alveolus" EXACT [] synonym: "epithelium of pulmonary alveolus" EXACT [] synonym: "pulmonary alveolar epithelium" EXACT [] synonym: "pulmonary alveolus epithelium" EXACT [] is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000487 ! simple squamous epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0004894 ! alveolar wall [Term] id: UBERON:0004823 name: intrahepatic bile duct epithelium def: "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." [] synonym: "epithelial tissue of intrahepatic bile duct" EXACT [] synonym: "epithelium of intrahepatic bile duct" EXACT [] synonym: "intrahepatic bile duct epithelial tissue" EXACT [] is_a: UBERON:0004820 ! bile duct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003704 ! intrahepatic bile duct relationship: part_of UBERON:0003704 ! intrahepatic bile duct [Term] id: UBERON:0004827 name: thyroid gland medulla def: "A medulla that is part of a thyroid [Automatically generated definition]." [] synonym: "medulla of thyroid" EXACT [] synonym: "medulla of thyroid follicle" EXACT [] synonym: "medulla of thyroid gland" EXACT [] synonym: "medulla of thyroid gland follicle" EXACT [] synonym: "thyroid follicle medulla" EXACT [] synonym: "thyroid gland follicle medulla" EXACT [] synonym: "thyroid medulla" EXACT [] is_a: UBERON:0000958 ! medulla is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000958 ! medulla intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland [Term] id: UBERON:0004829 name: urethra skeletal muscle def: "A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition]." [] synonym: "skeletal muscle of urethra" EXACT [] synonym: "skeletal muscle tissue of urethra" EXACT [] synonym: "urethra skeletal muscle tissue" EXACT [] synonym: "urethral skeletal muscle" RELATED [] is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0003829 ! urethra muscle [Term] id: UBERON:0004830 name: respiratory system skeletal muscle def: "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." [] synonym: "respiratory system skeletal muscle tissue" EXACT [] synonym: "skeletal muscle of apparatus respiratorius" EXACT [] synonym: "skeletal muscle of respiratory system" EXACT [] synonym: "skeletal muscle tissue of apparatus respiratorius" EXACT [] synonym: "skeletal muscle tissue of respiratory system" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0004831 name: esophagus skeletal muscle def: "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." [] synonym: "esophagus skeletal muscle tissue" EXACT [] synonym: "gullet skeletal muscle" EXACT [] synonym: "gullet skeletal muscle tissue" EXACT [] synonym: "oesophagus skeletal muscle" EXACT [] synonym: "oesophagus skeletal muscle tissue" EXACT [] synonym: "skeletal muscle of esophagus" EXACT [] synonym: "skeletal muscle of gullet" EXACT [] synonym: "skeletal muscle of oesophagus" EXACT [] synonym: "skeletal muscle tissue of esophagus" EXACT [] synonym: "skeletal muscle tissue of gullet" EXACT [] synonym: "skeletal muscle tissue of oesophagus" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0003832 ! esophagus muscle [Term] id: UBERON:0004832 name: anal region skeletal muscle def: "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." [] synonym: "anal part of perineum skeletal muscle" EXACT [] synonym: "anal part of perineum skeletal muscle tissue" EXACT [] synonym: "anal region skeletal muscle tissue" EXACT [] synonym: "anal triangle skeletal muscle" EXACT [] synonym: "anal triangle skeletal muscle tissue" EXACT [] synonym: "skeletal muscle of anal part of perineum" EXACT [] synonym: "skeletal muscle of anal region" EXACT [] synonym: "skeletal muscle of anal triangle" EXACT [] synonym: "skeletal muscle tissue of anal part of perineum" EXACT [] synonym: "skeletal muscle tissue of anal region" EXACT [] synonym: "skeletal muscle tissue of anal triangle" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0004834 name: hepatic duct smooth muscle def: "A smooth muscle tissue that is part of a hepatic duct." [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0005171 ! hepatic duct relationship: part_of UBERON:0005171 ! hepatic duct [Term] id: UBERON:0004835 name: epididymis smooth muscle def: "A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition]." [] synonym: "epididymis involuntary muscle" EXACT [] synonym: "epididymis non-striated muscle" EXACT [] synonym: "epididymis smooth muscle tissue" EXACT [] synonym: "epididymus involuntary muscle" EXACT [] synonym: "epididymus non-striated muscle" EXACT [] synonym: "epididymus smooth muscle" EXACT [] synonym: "epididymus smooth muscle tissue" EXACT [] synonym: "involuntary muscle of epididymis" EXACT [] synonym: "involuntary muscle of epididymus" EXACT [] synonym: "non-striated muscle of epididymis" EXACT [] synonym: "non-striated muscle of epididymus" EXACT [] synonym: "smooth muscle of epididymis" EXACT [] synonym: "smooth muscle of epididymus" EXACT [] synonym: "smooth muscle tissue of epididymis" EXACT [] synonym: "smooth muscle tissue of epididymus" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] id: UBERON:0004848 name: respiratory system arterial endothelium def: "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius arterial endothelium" EXACT [] synonym: "apparatus respiratorius artery endothelium" EXACT [] synonym: "apparatus respiratorius endothelium of artery" EXACT [] synonym: "arterial endothelium of apparatus respiratorius" EXACT [] synonym: "arterial endothelium of respiratory system" EXACT [] synonym: "artery endothelium of apparatus respiratorius" EXACT [] synonym: "artery endothelium of respiratory system" EXACT [] synonym: "endothelium of artery of apparatus respiratorius" EXACT [] synonym: "endothelium of artery of respiratory system" EXACT [] synonym: "respiratory system artery endothelium" EXACT [] synonym: "respiratory system endothelium of artery" EXACT [] is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001917 ! endothelium of artery intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003469 ! respiratory system artery relationship: part_of UBERON:0003504 ! respiratory system blood vessel relationship: part_of UBERON:0003643 ! respiratory system arterial blood vessel [Term] id: UBERON:0004849 name: respiratory system venous endothelium def: "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." [] synonym: "apparatus respiratorius endothelium of vein" EXACT [] synonym: "apparatus respiratorius vein endothelium" EXACT [] synonym: "apparatus respiratorius venous endothelium" EXACT [] synonym: "endothelium of vein of apparatus respiratorius" EXACT [] synonym: "endothelium of vein of respiratory system" EXACT [] synonym: "respiratory system endothelium of vein" EXACT [] synonym: "respiratory system vein endothelium" EXACT [] synonym: "vein endothelium of apparatus respiratorius" EXACT [] synonym: "vein endothelium of respiratory system" EXACT [] synonym: "venous endothelium of apparatus respiratorius" EXACT [] synonym: "venous endothelium of respiratory system" EXACT [] is_a: UBERON:0001919 ! endothelium of vein is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001919 ! endothelium of vein intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003476 ! respiratory system venous blood vessel relationship: part_of UBERON:0003504 ! respiratory system blood vessel [Term] id: UBERON:0004850 name: lymph node endothelium def: "An endothelium that is part of a lymph node [Automatically generated definition]." [] synonym: "endothelium of lymph node" EXACT [] is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0004851 name: aorta endothelium def: "An endothelium that is part of an aorta [Automatically generated definition]." [] synonym: "adult aorta endothelium" EXACT [] synonym: "aortic endothelium" RELATED [] synonym: "endothelium of adult aorta" EXACT [] synonym: "endothelium of aorta" EXACT [] synonym: "endothelium of trunk of aortic tree" EXACT [] synonym: "endothelium of trunk of systemic arterial tree" EXACT [] synonym: "trunk of aortic tree endothelium" EXACT [] synonym: "trunk of systemic arterial tree endothelium" EXACT [] is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0004852 name: cardiovascular system endothelium def: "An endothelium that is part of the cardiovascular system." [] is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0004535 ! cardiovascular system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0004854 name: gastrointestinal system mesentery def: "A mesentery that is part of a digestive system [Automatically generated definition]." [] synonym: "digestive system mesentery" EXACT [] synonym: "mesentery of digestive system" EXACT [] synonym: "mesentery of gastrointestinal system" EXACT [] is_a: UBERON:0002095 ! mesentery is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004859 name: eye gland def: "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." [] synonym: "eye-associated gland" EXACT [] synonym: "gland of eye" EXACT [] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye [Term] id: UBERON:0004864 name: vasculature of retina def: "A vasculature that is part of a retina [Automatically generated definition]." [] synonym: "retina vasculature" EXACT [] synonym: "retina vasculature of camera-type eye" EXACT [] synonym: "retinal blood vessels" EXACT [] synonym: "retinal blood vessels set" EXACT [] synonym: "retinal vasculature" EXACT [] synonym: "set of blood vessels of retina" EXACT [] synonym: "set of retinal blood vessels" EXACT [] synonym: "vasa sanguinea retinae" EXACT [] is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina [Term] id: UBERON:0004871 name: somatic layer of lateral plate mesoderm def: "Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP]." [] synonym: "outer layer of lateral plate mesoderm" EXACT [] synonym: "parietal mesoderm" RELATED [] synonym: "somatic mesoderm" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0004872 name: splanchnic layer of lateral plate mesoderm def: "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." [] synonym: "inner layer of lateral plate mesoderm" EXACT [] synonym: "splanchnic mesoderm" RELATED [] synonym: "visceral mesoderm" BROAD [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0004874 name: somatopleure def: "a structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0004875 name: nephrogenic cord def: "a portion of the urogenital ridge which is the source of much of the urinary system[WP]." [] synonym: "chorda nephrogenica" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0004876 ! urogenital ridge relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0004876 name: urogenital ridge def: "One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP]." [] synonym: "urethral fold" EXACT [] synonym: "urogenital fold" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: develops_from UBERON:0012292 ! embryonic cloacal fold relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0009196 ! indifferent external genitalia [Term] id: UBERON:0004880 name: chordamesoderm def: "The central region of trunk mesoderm. This tissue forms the notochord" [] synonym: "axial chorda mesoderm" EXACT [] synonym: "chorda mesoderm" EXACT [] synonym: "dorsal mesoderm" EXACT [] synonym: "presumptive notochord" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0003068 ! axial mesoderm [Term] id: UBERON:0004883 name: lung mesenchyme def: "the mass of tissue made up of mesenchymal cells in the lung." [] synonym: "lung-associated mesenchyme" EXACT [] synonym: "mesenchyme of lung" EXACT [] synonym: "pulmonary mesenchyme" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0002048 ! lung relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0004894 name: alveolar wall def: "A wall that contains the alveoli" [] synonym: "pulmonary alveolar wall" EXACT [] synonym: "pulmonary interalveolar septum" EXACT [] synonym: "wall of pulmonary alveolus" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung [Term] id: UBERON:0004895 name: alveolar smooth muscle def: "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus" [] is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung [Term] id: UBERON:0004902 name: urogenital sinus epithelium def: "The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra" [] synonym: "epithelium of urogenital sinus" EXACT [] synonym: "UGE" EXACT [] is_a: UBERON:0009846 ! embryonic cloacal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000164 ! primitive urogenital sinus relationship: develops_from UBERON:0009846 ! embryonic cloacal epithelium relationship: part_of UBERON:0000164 ! primitive urogenital sinus [Term] id: UBERON:0004905 name: articulation def: "anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts." [] synonym: "joint" NARROW [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0004906 name: ectodermal part of digestive tract def: "A portion of the gut that is derived from ectoderm." [] synonym: "ectodermal gut" EXACT [] synonym: "gut ectoderm" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0000924 ! ectoderm relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0004907 name: lower digestive tract def: "the region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." [] synonym: "gut" BROAD [] synonym: "lower gastrointestinal tract" EXACT [] synonym: "lower GI tract" EXACT [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: develops_from UBERON:0001046 ! hindgut relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0004909 name: epithelium of gonad def: "An epithelium surrounding a gonad." [] synonym: "gonad epithelium" EXACT [] synonym: "gonadal epithelium" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000991 ! gonad relationship: part_of UBERON:0000991 ! gonad [Term] id: UBERON:0004910 name: epithelium of male gonad def: "An epithelium surrounding a testis." [] synonym: "testis epithelium" EXACT [] synonym: "testis sheath" NARROW [] is_a: UBERON:0004909 ! epithelium of gonad is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000473 ! testis relationship: part_of UBERON:0000473 ! testis [Term] id: UBERON:0004911 name: epithelium of female gonad def: "An epithelium surrounding an ovary." [] synonym: "ovarian epithelium" EXACT [] synonym: "ovarian sheath" NARROW [] synonym: "ovary epithelium" EXACT [] is_a: UBERON:0004909 ! epithelium of gonad is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0004912 name: biliary bud synonym: "hepatic diverticulum" RELATED [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0009497 ! epithelium of foregut-midgut junction relationship: develops_from UBERON:0004161 ! septum transversum relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0004916 name: anal sphincter synonym: "anal region sphincter" EXACT [] synonym: "sphincter analia" EXACT [] is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0004917 name: urethral sphincter def: "A sphincter muscle surrounding the urethra." [] synonym: "sphincter muscle of urethra" EXACT [] synonym: "sphincter of urethra" EXACT [] synonym: "sphincter urethrae" EXACT [] synonym: "urethral sphincter muscle" EXACT [] is_a: UBERON:0003829 ! urethra muscle is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0001556 ! lower urinary tract [Term] id: UBERON:0004921 name: subdivision of digestive tract def: "A proximal-distal subdivision of the digestive tract." [] synonym: "alimentary system subdivision" RELATED [] synonym: "subdivision of alimentary system" RELATED [] is_a: UBERON:0013522 ! subdivision of tube relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0004923 name: organ component layer def: "Organ component which is a part of a wall of an organ." [] is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0000060 ! anatomical wall [Term] id: UBERON:0004924 name: submucosa of pharynx def: "The tissue underlying the tunica mucosa of the pharynx." [] synonym: "pharyngeal submucosa" EXACT [] synonym: "pharyngobasilar fascia" RELATED [] synonym: "pharynx submucosa" EXACT [] synonym: "submucous coat of pharynx" RELATED [] synonym: "submucous layer of pharynx" RELATED [] synonym: "tela submucosa pharyngis" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0004927 name: submucosa of cecum def: "A submucosa that is part of a cecum [Automatically generated definition]." [] synonym: "caecum submucosa" EXACT [] synonym: "cecum submucosa" EXACT [] synonym: "intestinum crassum caecum submucosa" EXACT [] synonym: "submucosa of caecum" EXACT [] synonym: "submucosa of intestinum crassum caecum" EXACT [] is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: UBERON:0004928 name: submucosa of appendix def: "A submucosa that is part of an appendix [Automatically generated definition]." [] synonym: "appendiceal submucosa" EXACT [] synonym: "appendix submucosa" EXACT [] synonym: "caecal appendix submucosa" EXACT [] synonym: "submucosa of caecal appendix" EXACT [] synonym: "submucosa of vermiform appendix" EXACT [] synonym: "submucosa of vermix" EXACT [] synonym: "vermiform appendix submucosa" EXACT [] synonym: "vermix submucosa" EXACT [] is_a: UBERON:0004927 ! submucosa of cecum intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: UBERON:0004929 name: submucosa of ascending colon def: "A submucosa that is part of an ascending colon [Automatically generated definition]." [] synonym: "ascending colon submucosa" EXACT [] is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001156 ! ascending colon relationship: part_of UBERON:0001156 ! ascending colon [Term] id: UBERON:0004930 name: submucosa of transverse colon def: "A submucosa that is part of a transverse colon [Automatically generated definition]." [] synonym: "transverse colon submucosa" EXACT [] is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001157 ! transverse colon relationship: part_of UBERON:0001157 ! transverse colon [Term] id: UBERON:0004931 name: submucosa of descending colon def: "A submucosa that is part of a descending colon [Automatically generated definition]." [] synonym: "descending colon submucosa" EXACT [] is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001158 ! descending colon relationship: part_of UBERON:0001158 ! descending colon [Term] id: UBERON:0004932 name: submucosa of sigmoid colon def: "A submucosa that is part of a sigmoid colon [Automatically generated definition]." [] synonym: "sigmoid colon submucosa" EXACT [] is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:0001159 ! sigmoid colon [Term] id: UBERON:0004933 name: submucosa of fundus of stomach def: "A submucosa that is part of a fundus of stomach [Automatically generated definition]." [] synonym: "fundus gastricus (ventricularis) submucosa" EXACT [] synonym: "fundus of stomach submucosa" EXACT [] synonym: "stomach fundus submucosa" EXACT [] synonym: "submucosa of fundus gastricus (ventricularis)" EXACT [] synonym: "submucosa of stomach fundus" EXACT [] is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach [Term] id: UBERON:0004935 name: submucosa of cardia of stomach def: "A submucosa that is part of a cardia of stomach [Automatically generated definition]." [] synonym: "cardia of stomach submucosa" EXACT [] synonym: "cardial part of stomach submucosa" EXACT [] synonym: "gastric cardia submucosa" EXACT [] synonym: "pars cardiaca (gaster) submucosa" EXACT [] synonym: "stomach cardiac region submucosa" EXACT [] synonym: "submucosa of cardial part of stomach" EXACT [] synonym: "submucosa of gastric cardia" EXACT [] synonym: "submucosa of pars cardiaca (gaster)" EXACT [] synonym: "submucosa of stomach cardiac region" EXACT [] is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0001162 ! cardia of stomach [Term] id: UBERON:0004936 name: submucosa of pyloric antrum def: "A submucosa that is part of a pyloric antrum [Automatically generated definition]." [] synonym: "antrum of stomach submucosa" EXACT [] synonym: "pyloric antrum submucosa" EXACT [] synonym: "stomach pyloric antrum submucosa" EXACT [] synonym: "submucosa of antrum of stomach" EXACT [] synonym: "submucosa of stomach pyloric antrum" EXACT [] is_a: UBERON:0004937 ! submucosa of pylorus intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001165 ! pyloric antrum relationship: part_of UBERON:0001165 ! pyloric antrum [Term] id: UBERON:0004937 name: submucosa of pylorus def: "A submucosa that is part of a pylorus [Automatically generated definition]." [] synonym: "pyloric part of stomach submucosa" EXACT [] synonym: "pyloric submucosa" EXACT [] synonym: "pylorus submucosa" EXACT [] synonym: "stomach pyloric region submucosa" EXACT [] synonym: "submucosa of pyloric part of stomach" EXACT [] synonym: "submucosa of stomach pyloric region" EXACT [] is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus [Term] id: UBERON:0004938 name: submucosa of biliary tree def: "A submucosa that is part of a biliary tree [Automatically generated definition]." [] synonym: "biliary tract submucosa" EXACT [] synonym: "biliary tree submucosa" EXACT [] synonym: "submucosa of biliary tract" EXACT [] is_a: UBERON:0000009 ! submucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001173 ! biliary tree relationship: part_of UBERON:0001173 ! biliary tree [Term] id: UBERON:0004943 name: submucosa of urinary bladder def: "The submucous layer of the wall of the urinary bladder." [] synonym: "bladder submucosa" EXACT [] synonym: "submucosa of bladder" EXACT [] synonym: "submucous layer of urinary bladder" RELATED [] synonym: "tela submucosa vesicae" EXACT [] synonym: "tela submucosa vesicae urinariae" EXACT [] synonym: "urinary bladder submucosa" EXACT [] is_a: UBERON:0000009 ! submucosa is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 ! wall of urinary bladder [Term] id: UBERON:0004944 name: submucosa of trigone of urinary bladder def: "A submucosa that is part of a trigone of urinary bladder [Automatically generated definition]." [] synonym: "deep trigone submucosa" EXACT [] synonym: "Lieutaud ' s trigone submucosa" EXACT [] synonym: "submucosa of deep trigone" EXACT [] synonym: "submucosa of Lieutaud ' s trigone" EXACT [] synonym: "submucosa of trigone of bladder" EXACT [] synonym: "submucosa of urinary bladder trigone" EXACT [] synonym: "submucosa of vesical trigone" EXACT [] synonym: "trigone of bladder submucosa" EXACT [] synonym: "trigone of urinary bladder submucosa" EXACT [] synonym: "urinary bladder trigone submucosa" EXACT [] synonym: "vesical trigone submucosa" EXACT [] is_a: UBERON:0004943 ! submucosa of urinary bladder intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder relationship: part_of UBERON:0001257 ! trigone of urinary bladder [Term] id: UBERON:0004946 name: submucosa of ileum def: "A submucosa that is part of a ileum [Automatically generated definition]." [] synonym: "ileal submucosa" EXACT [] synonym: "ileum submucosa" EXACT [] is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: UBERON:0004952 name: submucosa of bronchiole def: "A submucosa that is part of a bronchiole [Automatically generated definition]." [] synonym: "bronchiole submucosa" EXACT [] synonym: "lobular bronchiole submucosa" EXACT [] synonym: "submucosa of lobular bronchiole" EXACT [] is_a: UBERON:0001957 ! submucosa of bronchus intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002186 ! bronchiole relationship: part_of UBERON:0002186 ! bronchiole [Term] id: UBERON:0004980 name: mucosa of ureter def: "A mucosa that is part of a ureter [Automatically generated definition]." [] synonym: "mucosa of organ of ureter" EXACT [] synonym: "mucosal layer of ureter" EXACT [] synonym: "mucous membrane of ureter" EXACT [] synonym: "organ mucosa of ureter" EXACT [] synonym: "tunica mucosa (ureter)" EXACT [] synonym: "tunica mucosa ureteris" EXACT [] synonym: "ureter mucosa" EXACT [] synonym: "ureter mucosa of organ" EXACT [] synonym: "ureter mucous membrane" EXACT [] synonym: "ureter organ mucosa" EXACT [] synonym: "ureteral mucosa" EXACT [] synonym: "ureteric mucosa" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0009916 ! wall of ureter [Term] id: UBERON:0004983 name: mucosa of vagina def: "A mucosa that is part of a vagina [Automatically generated definition]." [] synonym: "mucosa of organ of vagina" EXACT [] synonym: "mucous membrane of vagina" EXACT [] synonym: "organ mucosa of vagina" EXACT [] synonym: "tunica mucosa vaginae" EXACT [] synonym: "vagina mucosa" EXACT [] synonym: "vagina mucosa of organ" EXACT [] synonym: "vagina mucous membrane" EXACT [] synonym: "vagina organ mucosa" EXACT [] synonym: "vaginal mucosa" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0004984 name: mucosa of seminal vesicle def: "A mucosa that is part of a seminal vesicle [Automatically generated definition]." [] synonym: "mucosa of organ of seminal gland" EXACT [] synonym: "mucosa of organ of seminal vesicle" EXACT [] synonym: "mucosa of seminal gland" EXACT [] synonym: "mucous membrane of seminal gland" EXACT [] synonym: "mucous membrane of seminal vesicle" EXACT [] synonym: "organ mucosa of seminal gland" EXACT [] synonym: "organ mucosa of seminal vesicle" EXACT [] synonym: "seminal gland mucosa" EXACT [] synonym: "seminal gland mucosa of organ" EXACT [] synonym: "seminal gland mucous membrane" EXACT [] synonym: "seminal gland organ mucosa" EXACT [] synonym: "seminal vesicle mucosa" EXACT [] synonym: "seminal vesicle mucosa of organ" EXACT [] synonym: "seminal vesicle mucous membrane" EXACT [] synonym: "seminal vesicle organ mucosa" EXACT [] synonym: "tunica mucosa glandulae vesiculosae" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle [Term] id: UBERON:0004989 name: mucosa of appendix def: "A mucosa that is part of an appendix [Automatically generated definition]." [] synonym: "appendiceal mucous membrane" EXACT [] synonym: "appendix mucosa" EXACT [] synonym: "appendix mucosa of organ" EXACT [] synonym: "appendix mucous membrane" EXACT [] synonym: "appendix organ mucosa" EXACT [] synonym: "caecal appendix mucosa" EXACT [] synonym: "caecal appendix mucosa of organ" EXACT [] synonym: "caecal appendix mucous membrane" EXACT [] synonym: "caecal appendix organ mucosa" EXACT [] synonym: "mucosa of caecal appendix" EXACT [] synonym: "mucosa of organ of appendix" EXACT [] synonym: "mucosa of organ of caecal appendix" EXACT [] synonym: "mucosa of organ of vermiform appendix" EXACT [] synonym: "mucosa of organ of vermix" EXACT [] synonym: "mucosa of vermiform appendix" EXACT [] synonym: "mucosa of vermix" EXACT [] synonym: "mucous membrane of appendix" EXACT [] synonym: "mucous membrane of caecal appendix" EXACT [] synonym: "mucous membrane of vermiform appendix" EXACT [] synonym: "mucous membrane of vermix" EXACT [] synonym: "organ mucosa of appendix" EXACT [] synonym: "organ mucosa of caecal appendix" EXACT [] synonym: "organ mucosa of vermiform appendix" EXACT [] synonym: "organ mucosa of vermix" EXACT [] synonym: "vermiform appendix mucosa" EXACT [] synonym: "vermiform appendix mucosa of organ" EXACT [] synonym: "vermiform appendix mucous membrane" EXACT [] synonym: "vermiform appendix organ mucosa" EXACT [] synonym: "vermix mucosa" EXACT [] synonym: "vermix mucosa of organ" EXACT [] synonym: "vermix mucous membrane" EXACT [] synonym: "vermix organ mucosa" EXACT [] is_a: UBERON:0000314 ! cecum mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: UBERON:0004990 name: mucosa of ascending colon def: "A mucosa that is part of an ascending colon [Automatically generated definition]." [] synonym: "ascending colon mucosa" EXACT [] synonym: "ascending colon mucosa of organ" EXACT [] synonym: "ascending colon mucous membrane" EXACT [] synonym: "ascending colon organ mucosa" EXACT [] synonym: "mucosa of organ of ascending colon" EXACT [] synonym: "mucous membrane of ascending colon" EXACT [] synonym: "organ mucosa of ascending colon" EXACT [] is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001156 ! ascending colon relationship: part_of UBERON:0001156 ! ascending colon [Term] id: UBERON:0004991 name: mucosa of transverse colon def: "A mucosa that is part of a transverse colon [Automatically generated definition]." [] synonym: "mucosa of organ of transverse colon" EXACT [] synonym: "mucous membrane of transverse colon" EXACT [] synonym: "organ mucosa of transverse colon" EXACT [] synonym: "transverse colon mucosa" EXACT [] synonym: "transverse colon mucosa of organ" EXACT [] synonym: "transverse colon mucous membrane" EXACT [] synonym: "transverse colon organ mucosa" EXACT [] is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001157 ! transverse colon relationship: part_of UBERON:0001157 ! transverse colon [Term] id: UBERON:0004992 name: mucosa of descending colon def: "A mucosa that is part of a descending colon [Automatically generated definition]." [] synonym: "descending colon mucosa" EXACT [] synonym: "descending colon mucosa of organ" EXACT [] synonym: "descending colon mucous membrane" EXACT [] synonym: "descending colon organ mucosa" EXACT [] synonym: "mucosa of organ of descending colon" EXACT [] synonym: "mucous membrane of descending colon" EXACT [] synonym: "organ mucosa of descending colon" EXACT [] is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001158 ! descending colon relationship: part_of UBERON:0001158 ! descending colon [Term] id: UBERON:0004993 name: mucosa of sigmoid colon def: "A mucosa that is part of a sigmoid colon [Automatically generated definition]." [] synonym: "mucosa of organ of sigmoid colon" EXACT [] synonym: "mucous membrane of sigmoid colon" EXACT [] synonym: "organ mucosa of sigmoid colon" EXACT [] synonym: "sigmoid colon mucosa" EXACT [] synonym: "sigmoid colon mucosa of organ" EXACT [] synonym: "sigmoid colon mucous membrane" EXACT [] synonym: "sigmoid colon organ mucosa" EXACT [] is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:0001159 ! sigmoid colon [Term] id: UBERON:0004994 name: mucosa of fundus of stomach def: "A mucosa that is part of a fundus of stomach [Automatically generated definition]." [] synonym: "fundus gastricus (ventricularis) mucosa" EXACT [] synonym: "fundus gastricus (ventricularis) mucosa of organ" EXACT [] synonym: "fundus gastricus (ventricularis) mucous membrane" EXACT [] synonym: "fundus gastricus (ventricularis) organ mucosa" EXACT [] synonym: "fundus of stomach mucosa" EXACT [] synonym: "fundus of stomach mucosa of organ" EXACT [] synonym: "fundus of stomach mucous membrane" EXACT [] synonym: "fundus of stomach organ mucosa" EXACT [] synonym: "mucosa of fundus gastricus (ventricularis)" EXACT [] synonym: "mucosa of organ of fundus gastricus (ventricularis)" EXACT [] synonym: "mucosa of organ of fundus of stomach" EXACT [] synonym: "mucosa of organ of stomach fundus" EXACT [] synonym: "mucosa of stomach fundus" EXACT [] synonym: "mucous membrane of fundus gastricus (ventricularis)" EXACT [] synonym: "mucous membrane of fundus of stomach" EXACT [] synonym: "mucous membrane of stomach fundus" EXACT [] synonym: "organ mucosa of fundus gastricus (ventricularis)" EXACT [] synonym: "organ mucosa of fundus of stomach" EXACT [] synonym: "organ mucosa of stomach fundus" EXACT [] synonym: "stomach fundus mucosa" EXACT [] synonym: "stomach fundus mucosa of organ" EXACT [] synonym: "stomach fundus mucous membrane" EXACT [] synonym: "stomach fundus organ mucosa" EXACT [] is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach [Term] id: UBERON:0004996 name: mucosa of cardia of stomach def: "A mucosa that is part of a cardia of stomach [Automatically generated definition]." [] synonym: "cardia of stomach mucosa" EXACT [] synonym: "cardia of stomach mucosa of organ" EXACT [] synonym: "cardia of stomach mucous membrane" EXACT [] synonym: "cardia of stomach organ mucosa" EXACT [] synonym: "cardial part of stomach mucosa" EXACT [] synonym: "cardial part of stomach mucosa of organ" EXACT [] synonym: "cardial part of stomach mucous membrane" EXACT [] synonym: "cardial part of stomach organ mucosa" EXACT [] synonym: "gastric cardia mucosa" EXACT [] synonym: "gastric cardia mucosa of organ" EXACT [] synonym: "gastric cardia mucous membrane" EXACT [] synonym: "gastric cardia organ mucosa" EXACT [] synonym: "mucosa of cardial part of stomach" EXACT [] synonym: "mucosa of gastric cardia" EXACT [] synonym: "mucosa of organ of cardia of stomach" EXACT [] synonym: "mucosa of organ of cardial part of stomach" EXACT [] synonym: "mucosa of organ of gastric cardia" EXACT [] synonym: "mucosa of organ of pars cardiaca (gaster)" EXACT [] synonym: "mucosa of organ of stomach cardiac region" EXACT [] synonym: "mucosa of pars cardiaca (gaster)" EXACT [] synonym: "mucosa of stomach cardiac region" EXACT [] synonym: "mucous membrane of cardia of stomach" EXACT [] synonym: "mucous membrane of cardial part of stomach" EXACT [] synonym: "mucous membrane of gastric cardia" EXACT [] synonym: "mucous membrane of pars cardiaca (gaster)" EXACT [] synonym: "mucous membrane of stomach cardiac region" EXACT [] synonym: "organ mucosa of cardia of stomach" EXACT [] synonym: "organ mucosa of cardial part of stomach" EXACT [] synonym: "organ mucosa of gastric cardia" EXACT [] synonym: "organ mucosa of pars cardiaca (gaster)" EXACT [] synonym: "organ mucosa of stomach cardiac region" EXACT [] synonym: "pars cardiaca (gaster) mucosa" EXACT [] synonym: "pars cardiaca (gaster) mucosa of organ" EXACT [] synonym: "pars cardiaca (gaster) mucous membrane" EXACT [] synonym: "pars cardiaca (gaster) organ mucosa" EXACT [] synonym: "stomach cardiac region mucosa" EXACT [] synonym: "stomach cardiac region mucosa of organ" EXACT [] synonym: "stomach cardiac region mucous membrane" EXACT [] synonym: "stomach cardiac region organ mucosa" EXACT [] is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0001162 ! cardia of stomach [Term] id: UBERON:0004997 name: mucosa of pyloric antrum def: "A mucosa that is part of a pyloric antrum [Automatically generated definition]." [] synonym: "antral mucosa" EXACT [] synonym: "antrum of stomach mucosa" EXACT [] synonym: "antrum of stomach mucosa of organ" EXACT [] synonym: "antrum of stomach mucous membrane" EXACT [] synonym: "antrum of stomach organ mucosa" EXACT [] synonym: "gastric antrum mucosa" RELATED [] synonym: "mucosa of antrum of stomach" EXACT [] synonym: "mucosa of organ of antrum of stomach" EXACT [] synonym: "mucosa of organ of pyloric antrum" EXACT [] synonym: "mucosa of organ of stomach pyloric antrum" EXACT [] synonym: "mucosa of stomach pyloric antrum" EXACT [] synonym: "mucous membrane of antrum of stomach" EXACT [] synonym: "mucous membrane of pyloric antrum" EXACT [] synonym: "mucous membrane of stomach pyloric antrum" EXACT [] synonym: "organ mucosa of antrum of stomach" EXACT [] synonym: "organ mucosa of pyloric antrum" EXACT [] synonym: "organ mucosa of stomach pyloric antrum" EXACT [] synonym: "pyloric antrum mucosa" EXACT [] synonym: "pyloric antrum mucosa of organ" EXACT [] synonym: "pyloric antrum mucous membrane" EXACT [] synonym: "pyloric antrum organ mucosa" EXACT [] synonym: "stomach pyloric antrum mucosa" EXACT [] synonym: "stomach pyloric antrum mucosa of organ" EXACT [] synonym: "stomach pyloric antrum mucous membrane" EXACT [] synonym: "stomach pyloric antrum organ mucosa" EXACT [] is_a: UBERON:0004998 ! mucosa of pylorus intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001165 ! pyloric antrum relationship: part_of UBERON:0001165 ! pyloric antrum relationship: part_of UBERON:0004998 ! mucosa of pylorus [Term] id: UBERON:0004998 name: mucosa of pylorus def: "A mucosa that is part of a pylorus [Automatically generated definition]." [] synonym: "antropyloric mucosa" RELATED [] synonym: "mucosa of organ of pyloric part of stomach" EXACT [] synonym: "mucosa of organ of pylorus" EXACT [] synonym: "mucosa of organ of stomach pyloric region" EXACT [] synonym: "mucosa of pyloric part of stomach" EXACT [] synonym: "mucosa of stomach pyloric region" EXACT [] synonym: "mucous membrane of pyloric part of stomach" EXACT [] synonym: "mucous membrane of pylorus" EXACT [] synonym: "mucous membrane of stomach pyloric region" EXACT [] synonym: "organ mucosa of pyloric part of stomach" EXACT [] synonym: "organ mucosa of pylorus" EXACT [] synonym: "organ mucosa of stomach pyloric region" EXACT [] synonym: "pyloric part of stomach mucosa" EXACT [] synonym: "pyloric part of stomach mucosa of organ" EXACT [] synonym: "pyloric part of stomach mucous membrane" EXACT [] synonym: "pyloric part of stomach organ mucosa" EXACT [] synonym: "pylorus mucosa" EXACT [] synonym: "pylorus mucosa of organ" EXACT [] synonym: "pylorus mucous membrane" EXACT [] synonym: "pylorus organ mucosa" EXACT [] synonym: "stomach pyloric region mucosa" EXACT [] synonym: "stomach pyloric region mucosa of organ" EXACT [] synonym: "stomach pyloric region mucous membrane" EXACT [] synonym: "stomach pyloric region organ mucosa" EXACT [] is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus [Term] id: UBERON:0004999 name: mucosa of biliary tree def: "A mucosa that is part of a biliary tree [Automatically generated definition]." [] synonym: "biliary tract mucosa" EXACT [] synonym: "biliary tract mucosa of organ" EXACT [] synonym: "biliary tract mucous membrane" EXACT [] synonym: "biliary tract organ mucosa" EXACT [] synonym: "biliary tree mucosa" EXACT [] synonym: "biliary tree mucosa of organ" EXACT [] synonym: "biliary tree mucous membrane" EXACT [] synonym: "biliary tree organ mucosa" EXACT [] synonym: "mucosa of biliary tract" EXACT [] synonym: "mucosa of organ of biliary tract" EXACT [] synonym: "mucosa of organ of biliary tree" EXACT [] synonym: "mucous membrane of biliary tract" EXACT [] synonym: "mucous membrane of biliary tree" EXACT [] synonym: "organ mucosa of biliary tract" EXACT [] synonym: "organ mucosa of biliary tree" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001173 ! biliary tree relationship: part_of UBERON:0001173 ! biliary tree [Term] id: UBERON:0005006 name: mucosa of renal pelvis def: "A mucosa that is part of a renal pelvis [Automatically generated definition]." [] synonym: "kidney pelvis mucosa" EXACT [] synonym: "kidney pelvis mucosa of organ" EXACT [] synonym: "kidney pelvis mucous membrane" EXACT [] synonym: "kidney pelvis organ mucosa" EXACT [] synonym: "mucosa of kidney pelvis" EXACT [] synonym: "mucosa of organ of kidney pelvis" EXACT [] synonym: "mucosa of organ of pelvis of ureter" EXACT [] synonym: "mucosa of organ of renal pelvis" EXACT [] synonym: "mucosa of pelvis of ureter" EXACT [] synonym: "mucous membrane of kidney pelvis" EXACT [] synonym: "mucous membrane of pelvis of ureter" EXACT [] synonym: "mucous membrane of renal pelvis" EXACT [] synonym: "organ mucosa of kidney pelvis" EXACT [] synonym: "organ mucosa of pelvis of ureter" EXACT [] synonym: "organ mucosa of renal pelvis" EXACT [] synonym: "pelvis of ureter mucosa" EXACT [] synonym: "pelvis of ureter mucosa of organ" EXACT [] synonym: "pelvis of ureter mucous membrane" EXACT [] synonym: "pelvis of ureter organ mucosa" EXACT [] synonym: "renal pelvic mucosa" EXACT [] synonym: "renal pelvis mucosa" EXACT [] synonym: "renal pelvis mucosa of organ" EXACT [] synonym: "renal pelvis mucous membrane" EXACT [] synonym: "renal pelvis organ mucosa" EXACT [] synonym: "tunica mucosa pelvis renalis" EXACT [] is_a: UBERON:0004980 ! mucosa of ureter intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis [Term] id: UBERON:0005009 name: mucosa of trigone of urinary bladder def: "A mucosa that is part of a trigone of urinary bladder [Automatically generated definition]." [] synonym: "deep trigone mucosa" EXACT [] synonym: "deep trigone mucosa of organ" EXACT [] synonym: "deep trigone mucous membrane" EXACT [] synonym: "deep trigone organ mucosa" EXACT [] synonym: "Lieutaud ' s trigone mucosa" EXACT [] synonym: "Lieutaud ' s trigone mucosa of organ" EXACT [] synonym: "Lieutaud ' s trigone mucous membrane" EXACT [] synonym: "Lieutaud ' s trigone organ mucosa" EXACT [] synonym: "mucosa of deep trigone" EXACT [] synonym: "mucosa of Lieutaud ' s trigone" EXACT [] synonym: "mucosa of organ of deep trigone" EXACT [] synonym: "mucosa of organ of Lieutaud ' s trigone" EXACT [] synonym: "mucosa of organ of trigone of bladder" EXACT [] synonym: "mucosa of organ of trigone of urinary bladder" EXACT [] synonym: "mucosa of organ of urinary bladder trigone" EXACT [] synonym: "mucosa of organ of vesical trigone" EXACT [] synonym: "mucosa of trigone of bladder" EXACT [] synonym: "mucosa of urinary bladder trigone" EXACT [] synonym: "mucosa of vesical trigone" EXACT [] synonym: "mucous membrane of deep trigone" EXACT [] synonym: "mucous membrane of Lieutaud ' s trigone" EXACT [] synonym: "mucous membrane of trigone of bladder" EXACT [] synonym: "mucous membrane of trigone of urinary bladder" EXACT [] synonym: "mucous membrane of urinary bladder trigone" EXACT [] synonym: "mucous membrane of vesical trigone" EXACT [] synonym: "organ mucosa of deep trigone" EXACT [] synonym: "organ mucosa of Lieutaud ' s trigone" EXACT [] synonym: "organ mucosa of trigone of bladder" EXACT [] synonym: "organ mucosa of trigone of urinary bladder" EXACT [] synonym: "organ mucosa of urinary bladder trigone" EXACT [] synonym: "organ mucosa of vesical trigone" EXACT [] synonym: "trigone of bladder mucosa" EXACT [] synonym: "trigone of bladder mucosa of organ" EXACT [] synonym: "trigone of bladder mucous membrane" EXACT [] synonym: "trigone of bladder organ mucosa" EXACT [] synonym: "trigone of urinary bladder mucosa" EXACT [] synonym: "trigone of urinary bladder mucosa of organ" EXACT [] synonym: "trigone of urinary bladder mucous membrane" EXACT [] synonym: "trigone of urinary bladder organ mucosa" EXACT [] synonym: "urinary bladder trigone mucosa" EXACT [] synonym: "urinary bladder trigone mucosa of organ" EXACT [] synonym: "urinary bladder trigone mucous membrane" EXACT [] synonym: "urinary bladder trigone organ mucosa" EXACT [] synonym: "vesical trigone mucosa" EXACT [] synonym: "vesical trigone mucosa of organ" EXACT [] synonym: "vesical trigone mucous membrane" EXACT [] synonym: "vesical trigone organ mucosa" EXACT [] is_a: UBERON:0001259 ! mucosa of urinary bladder intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder relationship: part_of UBERON:0001257 ! trigone of urinary bladder [Term] id: UBERON:0005013 name: mucosa of male urethra def: "A mucosa that is part of a male urethra [Automatically generated definition]." [] synonym: "male urethra mucosa" EXACT [] synonym: "male urethra mucosa of organ" EXACT [] synonym: "male urethra mucous membrane" EXACT [] synonym: "male urethra organ mucosa" EXACT [] synonym: "mucosa of organ of male urethra" EXACT [] synonym: "mucous membrane of male urethra" EXACT [] synonym: "organ mucosa of male urethra" EXACT [] is_a: UBERON:0012299 ! mucosa of urethra is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001333 ! male urethra relationship: part_of UBERON:0001333 ! male urethra [Term] id: UBERON:0005014 name: mucosa of female urethra def: "A mucosa that is part of a female urethra [Automatically generated definition]." [] synonym: "female urethra mucosa" EXACT [] synonym: "female urethra mucosa of organ" EXACT [] synonym: "female urethra mucous membrane" EXACT [] synonym: "female urethra organ mucosa" EXACT [] synonym: "mucosa of organ of female urethra" EXACT [] synonym: "mucous membrane of female urethra" EXACT [] synonym: "organ mucosa of female urethra" EXACT [] is_a: UBERON:0012299 ! mucosa of urethra is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001334 ! female urethra relationship: part_of UBERON:0001334 ! female urethra [Term] id: UBERON:0005017 name: mucosa of lacrimal sac def: "A mucosa that is part of a lacrimal sac [Automatically generated definition]." [] synonym: "lacrimal sac mucosa" EXACT [] synonym: "lacrimal sac mucosa of organ" EXACT [] synonym: "lacrimal sac mucous membrane" EXACT [] synonym: "lacrimal sac organ mucosa" EXACT [] synonym: "mucosa of organ of lacrimal sac" EXACT [] synonym: "mucous membrane of lacrimal sac" EXACT [] synonym: "organ mucosa of lacrimal sac" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001351 ! lacrimal sac relationship: part_of UBERON:0001351 ! lacrimal sac [Term] id: UBERON:0005020 name: mucosa of tongue def: "A mucosa that is part of a tongue [Automatically generated definition]." [] synonym: "lingual mucosa" EXACT [] synonym: "mucosa of organ of tongue" EXACT [] synonym: "mucous membrane of tongue" EXACT [] synonym: "organ mucosa of tongue" EXACT [] synonym: "tongue mucosa" EXACT [] synonym: "tongue mucosa of organ" EXACT [] synonym: "tongue mucous membrane" EXACT [] synonym: "tongue organ mucosa" EXACT [] synonym: "tunica mucosa linguae" EXACT [] is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0005022 name: mucosa of nasopharynx def: "A mucosa that is part of a nasopharynx [Automatically generated definition]." [] synonym: "mucosa of nasal part of pharynx" EXACT [] synonym: "mucosa of organ of nasal part of pharynx" EXACT [] synonym: "mucosa of organ of nasopharynx" EXACT [] synonym: "mucosa of organ of rhinopharynx" EXACT [] synonym: "mucosa of rhinopharynx" EXACT [] synonym: "mucous membrane of nasal part of pharynx" EXACT [] synonym: "mucous membrane of nasopharynx" EXACT [] synonym: "mucous membrane of rhinopharynx" EXACT [] synonym: "nasal part of pharynx mucosa" EXACT [] synonym: "nasal part of pharynx mucosa of organ" EXACT [] synonym: "nasal part of pharynx mucous membrane" EXACT [] synonym: "nasal part of pharynx organ mucosa" EXACT [] synonym: "nasopharynx mucosa" EXACT [] synonym: "nasopharynx mucosa of organ" EXACT [] synonym: "nasopharynx mucous membrane" EXACT [] synonym: "nasopharynx organ mucosa" EXACT [] synonym: "organ mucosa of nasal part of pharynx" EXACT [] synonym: "organ mucosa of nasopharynx" EXACT [] synonym: "organ mucosa of rhinopharynx" EXACT [] synonym: "rhinopharynx mucosa" EXACT [] synonym: "rhinopharynx mucosa of organ" EXACT [] synonym: "rhinopharynx mucous membrane" EXACT [] synonym: "rhinopharynx organ mucosa" EXACT [] is_a: UBERON:0000355 ! pharyngeal mucosa is_a: UBERON:0000379 ! tracheal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx [Term] id: UBERON:0005026 name: mucosa of middle ear def: "A mucosa that is part of a middle ear [Automatically generated definition]." [] synonym: "middle ear mucosa" EXACT [] synonym: "middle ear mucosa of organ" EXACT [] synonym: "middle ear mucous membrane" EXACT [] synonym: "middle ear organ mucosa" EXACT [] synonym: "mucosa of organ of middle ear" EXACT [] synonym: "mucosa of tympanic cavity" EXACT [] synonym: "mucous membrane of middle ear" EXACT [] synonym: "organ mucosa of middle ear" EXACT [] synonym: "tunica mucosa cavitatis tympanicae" EXACT [] is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001756 ! middle ear relationship: part_of UBERON:0001756 ! middle ear [Term] id: UBERON:0005029 name: mucosa of lacrimal canaliculus def: "A mucosa that is part of a lacrimal canaliculus [Automatically generated definition]." [] synonym: "lacrimal canalicular mucosa" EXACT [] synonym: "lacrimal canaliculus mucosa" EXACT [] synonym: "lacrimal canaliculus mucosa of organ" EXACT [] synonym: "lacrimal canaliculus mucous membrane" EXACT [] synonym: "lacrimal canaliculus organ mucosa" EXACT [] synonym: "mucosa of organ of lacrimal canaliculus" EXACT [] synonym: "mucous membrane of lacrimal canaliculus" EXACT [] synonym: "organ mucosa of lacrimal canaliculus" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001770 ! lacrimal canaliculus relationship: part_of UBERON:0001770 ! lacrimal canaliculus [Term] id: UBERON:0005033 name: mucosa of gallbladder def: "A mucosa that is part of a gallbladder [Automatically generated definition]." [] synonym: "gall bladder mucosa" EXACT [] synonym: "gall bladder mucosa of organ" EXACT [] synonym: "gall bladder mucous membrane" EXACT [] synonym: "gall bladder organ mucosa" EXACT [] synonym: "gallbladder mucosa" EXACT [] synonym: "gallbladder mucosa of organ" EXACT [] synonym: "gallbladder mucous membrane" EXACT [] synonym: "gallbladder organ mucosa" EXACT [] synonym: "mucosa of gall bladder" EXACT [] synonym: "mucosa of organ of gall bladder" EXACT [] synonym: "mucosa of organ of gallbladder" EXACT [] synonym: "mucous membrane of gall bladder" EXACT [] synonym: "mucous membrane of gallbladder" EXACT [] synonym: "organ mucosa of gall bladder" EXACT [] synonym: "organ mucosa of gallbladder" EXACT [] synonym: "tunica mucosa (vesica biliaris)" EXACT [] synonym: "tunica mucosa vesicae biliaris" EXACT [] is_a: UBERON:0004999 ! mucosa of biliary tree intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: UBERON:0005039 name: mucosa of bronchiole def: "A mucosa that is part of a bronchiole [Automatically generated definition]." [] synonym: "bronchiole mucosa" EXACT [] synonym: "bronchiole mucosa of organ" EXACT [] synonym: "bronchiole mucous membrane" EXACT [] synonym: "bronchiole organ mucosa" EXACT [] synonym: "lobular bronchiole mucosa" EXACT [] synonym: "lobular bronchiole mucosa of organ" EXACT [] synonym: "lobular bronchiole mucous membrane" EXACT [] synonym: "lobular bronchiole organ mucosa" EXACT [] synonym: "mucosa of lobular bronchiole" EXACT [] synonym: "mucosa of organ of bronchiole" EXACT [] synonym: "mucosa of organ of lobular bronchiole" EXACT [] synonym: "mucous membrane of bronchiole" EXACT [] synonym: "mucous membrane of lobular bronchiole" EXACT [] synonym: "organ mucosa of bronchiole" EXACT [] synonym: "organ mucosa of lobular bronchiole" EXACT [] is_a: UBERON:0000410 ! bronchial mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002186 ! bronchiole relationship: part_of UBERON:0002186 ! bronchiole [Term] id: UBERON:0005040 name: mucosa of terminal bronchiole def: "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." [] synonym: "bronchiolus terminalis mucosa" EXACT [] synonym: "bronchiolus terminalis mucosa of organ" EXACT [] synonym: "bronchiolus terminalis mucous membrane" EXACT [] synonym: "bronchiolus terminalis organ mucosa" EXACT [] synonym: "mucosa of bronchiolus terminalis" EXACT [] synonym: "mucosa of organ of bronchiolus terminalis" EXACT [] synonym: "mucosa of organ of terminal bronchiole" EXACT [] synonym: "mucous membrane of bronchiolus terminalis" EXACT [] synonym: "mucous membrane of terminal bronchiole" EXACT [] synonym: "organ mucosa of bronchiolus terminalis" EXACT [] synonym: "organ mucosa of terminal bronchiole" EXACT [] synonym: "terminal bronchiole mucosa" EXACT [] synonym: "terminal bronchiole mucosa of organ" EXACT [] synonym: "terminal bronchiole mucous membrane" EXACT [] synonym: "terminal bronchiole organ mucosa" EXACT [] is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002187 ! terminal bronchiole relationship: part_of UBERON:0002187 ! terminal bronchiole [Term] id: UBERON:0005041 name: mucosa of respiratory bronchiole def: "A mucosa that is part of a respiratory bronchiole [Automatically generated definition]." [] synonym: "bronchiolus respiratorius mucosa" EXACT [] synonym: "bronchiolus respiratorius mucosa of organ" EXACT [] synonym: "bronchiolus respiratorius mucous membrane" EXACT [] synonym: "bronchiolus respiratorius organ mucosa" EXACT [] synonym: "mucosa of bronchiolus respiratorius" EXACT [] synonym: "mucosa of organ of bronchiolus respiratorius" EXACT [] synonym: "mucosa of organ of respiratory bronchiole" EXACT [] synonym: "mucous membrane of bronchiolus respiratorius" EXACT [] synonym: "mucous membrane of respiratory bronchiole" EXACT [] synonym: "organ mucosa of bronchiolus respiratorius" EXACT [] synonym: "organ mucosa of respiratory bronchiole" EXACT [] synonym: "respiratory bronchiole mucosa" EXACT [] synonym: "respiratory bronchiole mucosa of organ" EXACT [] synonym: "respiratory bronchiole mucous membrane" EXACT [] synonym: "respiratory bronchiole organ mucosa" EXACT [] is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002188 ! respiratory bronchiole relationship: part_of UBERON:0002188 ! respiratory bronchiole [Term] id: UBERON:0005043 name: mucosa of nasolacrimal duct def: "A mucosa that is part of a nasolacrimal duct [Automatically generated definition]." [] synonym: "mucosa of organ of nasolacrimal duct" EXACT [] synonym: "mucous membrane of nasolacrimal duct" EXACT [] synonym: "nasolacrimal duct mucosa" EXACT [] synonym: "nasolacrimal duct mucosa of organ" EXACT [] synonym: "nasolacrimal duct mucous membrane" EXACT [] synonym: "nasolacrimal duct organ mucosa" EXACT [] synonym: "nasolacrimal ductal mucosa" EXACT [] synonym: "organ mucosa of nasolacrimal duct" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002392 ! nasolacrimal duct relationship: part_of UBERON:0002392 ! nasolacrimal duct [Term] id: UBERON:0005048 name: mucosa of uterine tube def: "A mucosa that is part of a fallopian tube [Automatically generated definition]." [] synonym: "fallopian tube mucosa" EXACT [] synonym: "fallopian tube mucosa of organ" EXACT [] synonym: "fallopian tube mucous membrane" EXACT [] synonym: "fallopian tube organ mucosa" EXACT [] synonym: "mucosa of fallopian tube" EXACT [] synonym: "mucosa of organ of fallopian tube" EXACT [] synonym: "mucosa of organ of uterine tube" EXACT [] synonym: "mucosa of oviduct" EXACT [] synonym: "mucous membrane of fallopian tube" EXACT [] synonym: "mucous membrane of uterine tube" EXACT [] synonym: "organ mucosa of fallopian tube" EXACT [] synonym: "organ mucosa of uterine tube" EXACT [] synonym: "tunica mucosa tubae uterinae" EXACT [] synonym: "uterine tubal mucosa" EXACT [] synonym: "uterine tube mucosa" EXACT [] synonym: "uterine tube mucosa of organ" EXACT [] synonym: "uterine tube mucous membrane" EXACT [] synonym: "uterine tube organ mucosa" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0003889 ! fallopian tube relationship: part_of UBERON:0003889 ! fallopian tube [Term] id: UBERON:0005055 name: zone of long bone def: "An organ part that is part of a long bone [Automatically generated definition]." [] synonym: "long bone zone" EXACT [] is_a: UBERON:0005913 ! zone of bone organ intersection_of: UBERON:0005913 ! zone of bone organ intersection_of: part_of UBERON:0002495 ! long bone relationship: part_of UBERON:0002495 ! long bone [Term] id: UBERON:0005056 name: external female genitalia def: "An external genitalia that is part of a female reproductive system [Automatically generated definition]." [] synonym: "external female genital organ" EXACT [] synonym: "external genitalia of female reproductive system" EXACT [] synonym: "female external genitalia" EXACT [] synonym: "organa genitalia feminina externa" RELATED [] is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004176 ! external genitalia intersection_of: UBERON:0004176 ! external genitalia intersection_of: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: UBERON:0005057 name: immune organ def: "An organ that is part of a immune system [Automatically generated definition]." [] synonym: "immune system organ" EXACT [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0002405 ! immune system relationship: part_of UBERON:0002405 ! immune system [Term] id: UBERON:0005058 name: hemolymphoid system gland def: "A gland that is part of a hemolymphoid system [Automatically generated definition]." [] synonym: "hemopoietic or lymphoid gland" EXACT [] synonym: "hemopoietic or lymphoid organ" BROAD [] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002193 ! hemolymphoid system relationship: part_of UBERON:0002193 ! hemolymphoid system [Term] id: UBERON:0005061 name: neural groove def: "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0003075 ! neural plate [Term] id: UBERON:0005062 name: neural fold def: "One of the two elevated edges of the neural groove[GO,MP]." [] synonym: "medullary fold" EXACT [] is_a: UBERON:0005157 ! epithelial fold is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: part_of UBERON:0005061 ! neural groove [Term] id: UBERON:0005068 name: neural rod def: "a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0002346 ! neurectoderm relationship: develops_from UBERON:0007135 ! neural keel relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0005080 name: metanephric ureteric bud def: "the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO]." [] is_a: UBERON:0000084 ! ureteric bud is_a: UBERON:0007497 ! developing epithelial placode [Term] id: UBERON:0005081 name: ureter ureteric bud def: "The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO]." [] is_a: UBERON:0000084 ! ureteric bud is_a: UBERON:0007497 ! developing epithelial placode [Term] id: UBERON:0005085 name: ectodermal placode def: "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]" [] is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: part_of UBERON:0000924 ! ectoderm relationship: part_of UBERON:0000924 ! ectoderm [Term] id: UBERON:0005086 name: hair follicle placode def: "An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud[GO]." [] synonym: "hair gem" RELATED [] synonym: "hair peg" RELATED [] synonym: "vibrissa placode" NARROW [] is_a: UBERON:0011817 ! follicle placode relationship: develops_from UBERON:0001003 ! epidermis relationship: develops_from UBERON:0011272 ! embryonic skin basal layer [Term] id: UBERON:0005087 name: tooth placode def: "An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO]." [] synonym: "dental placode" EXACT [] synonym: "dental primordium" EXACT [] synonym: "odontogenic placode" EXACT [] synonym: "tooth germ" RELATED [] is_a: UBERON:0011814 ! non-neurogenic ectodermal placode [Term] id: UBERON:0005088 name: sebaceous gland placode def: "A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO]." [] is_a: UBERON:0011814 ! non-neurogenic ectodermal placode relationship: develops_from UBERON:0011272 ! embryonic skin basal layer [Term] id: UBERON:0005089 name: sweat gland placode def: "An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO]." [] is_a: UBERON:0011814 ! non-neurogenic ectodermal placode relationship: develops_from UBERON:0011272 ! embryonic skin basal layer [Term] id: UBERON:0005090 name: muscle structure def: "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." [] synonym: "muscle" RELATED [] synonym: "muscle element" RELATED [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0005095 name: kidney rudiment def: "." [] synonym: "kidney anlage" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0007687 ! kidney field relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0005096 name: descending thin limb def: "The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle[GO]." [] synonym: "descending limb of henle%27s loop" RELATED [] synonym: "descending limb of loop of henle" RELATED [] synonym: "descending thin limb of loop of Henle" EXACT [] synonym: "loop of Henle descending thin limb" EXACT [] synonym: "loop of henle thin descending limb" EXACT [] synonym: "pars descendens (tubulus attenuatus)" EXACT [] synonym: "thin descending limb" EXACT [] synonym: "thin descending limb of loop of henle" RELATED [] synonym: "thin descending limb of the loop of henle" RELATED [] synonym: "thin descending loop of henle" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001288 ! loop of Henle relationship: part_of UBERON:0004136 ! intermediate tubule [Term] id: UBERON:0005097 name: renal connecting tubule def: "The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct[GO]." [] synonym: "connecting tubule" EXACT [] synonym: "kidney connecting tubule" EXACT [] synonym: "tubulus renalis arcuatus" RELATED [] is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0003220 ! metanephric mesenchyme [Term] id: UBERON:0005103 name: mesonephric epithelium def: "An epithelium that is part of a mesonephros [Automatically generated definition]." [] is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005106 name: metanephric tubule def: "A metanephric tubule is an epithelial tube that is part of the metanephros[GO]." [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005108 ! metanephric epithelium is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0003914 ! epithelial tube intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0005108 name: metanephric epithelium def: "An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO]." [] is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0005109 name: metanephric smooth muscle tissue def: "Any smooth muscle tissue that is part of a metanephros." [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0005110 name: metanephric nephron def: "A metanephric nephron is the functional unit of the metanephros[GO]." [] is_a: UBERON:0001285 ! nephron is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001285 ! nephron intersection_of: part_of UBERON:0000081 ! metanephros relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0005113 name: metanephric cortex mesenchyme is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0010531 ! metanephros induced blastemal cells [Term] id: UBERON:0005114 name: metanephric ascending thin limb def: "The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent[GO]." [] is_a: UBERON:0004193 ! loop of Henle ascending limb thin segment is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0004193 ! loop of Henle ascending limb thin segment intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005129 ! metanephric distal tubule [Term] id: UBERON:0005115 name: metanephric cortical collecting duct def: "The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO]." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004203 ! cortical collecting duct intersection_of: UBERON:0004203 ! cortical collecting duct intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004737 ! metanephric collecting duct relationship: part_of UBERON:0010533 ! metanephros cortex [Term] id: UBERON:0005116 name: metanephric descending thin limb def: "It extends to the tip of the metanephric loop of Henle[GO]." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005096 ! descending thin limb intersection_of: UBERON:0005096 ! descending thin limb intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005130 ! metanephric loop of Henle [Term] id: UBERON:0005117 name: metanephric distal convoluted tubule def: "The metanephric distal convoluted tubule is a portion of the metanephric nephron tubule that connects the metanephric loop of Henle to the collecting duct[GO]." [] is_a: UBERON:0001292 ! distal convoluted tubule is_a: UBERON:0005129 ! metanephric distal tubule intersection_of: UBERON:0001292 ! distal convoluted tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron relationship: part_of UBERON:0010533 ! metanephros cortex [Term] id: UBERON:0005119 name: metanephric glomerular mesangium def: "The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus[GO]." [] is_a: UBERON:0002320 ! glomerular mesangium intersection_of: UBERON:0002320 ! glomerular mesangium intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005133 ! metanephric glomerulus vasculature [Term] id: UBERON:0005122 name: metanephric macula densa def: "The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus[GO]." [] is_a: UBERON:0002335 ! macula densa is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002335 ! macula densa intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004738 ! metanephric juxtaglomerular apparatus [Term] id: UBERON:0005124 name: metanephric proximal convoluted tubule def: "The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule[GO]." [] is_a: UBERON:0001287 ! proximal convoluted tubule is_a: UBERON:0005151 ! metanephric proximal tubule intersection_of: UBERON:0001287 ! proximal convoluted tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron relationship: part_of UBERON:0010533 ! metanephros cortex [Term] id: UBERON:0005125 name: metanephric proximal straight tubule def: "The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule[GO]." [] is_a: UBERON:0001290 ! proximal straight tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001290 ! proximal straight tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron relationship: part_of UBERON:0005151 ! metanephric proximal tubule relationship: part_of UBERON:0010533 ! metanephros cortex [Term] id: UBERON:0005127 name: metanephric thick ascending limb def: "At the macula densa, the thick ascending limb connects to the distal convoluted tubule[GO]." [] is_a: UBERON:0001291 ! thick ascending limb of loop of Henle is_a: UBERON:0005129 ! metanephric distal tubule intersection_of: UBERON:0001291 ! thick ascending limb of loop of Henle intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005129 name: metanephric distal tubule def: "The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule[GO]." [] is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0004135 ! distal tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005130 name: metanephric loop of Henle def: "The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros[GO]." [] is_a: UBERON:0001288 ! loop of Henle is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001288 ! loop of Henle intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004136 ! intermediate tubule relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005133 name: metanephric glomerulus vasculature def: "The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO]." [] is_a: UBERON:0004190 ! renal glomerulus vasculature intersection_of: UBERON:0004190 ! renal glomerulus vasculature intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004736 ! metanephric glomerulus [Term] id: UBERON:0005134 name: metanephric nephron epithelium def: "The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO]." [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0005108 ! metanephric epithelium intersection_of: UBERON:0004211 ! nephron epithelium intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005135 name: metanephric glomerular epithelium def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO]." [] is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0004188 ! glomerular epithelium intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004736 ! metanephric glomerulus relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005136 name: metanephric glomerular endothelium def: "The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO]." [] is_a: UBERON:0004189 ! glomerular endothelium is_a: UBERON:0005135 ! metanephric glomerular epithelium intersection_of: UBERON:0004189 ! glomerular endothelium intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004736 ! metanephric glomerulus relationship: part_of UBERON:0005110 ! metanephric nephron relationship: part_of UBERON:0005133 ! metanephric glomerulus vasculature [Term] id: UBERON:0005144 name: metanephric glomerular capillary def: "This process pertains to the initial formation of a structure from unspecified parts[GO]." [] is_a: UBERON:0004212 ! glomerular capillary intersection_of: UBERON:0004212 ! glomerular capillary intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0004736 ! metanephric glomerulus relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005145 name: metanephric comma-shaped body def: "The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." [] is_a: UBERON:0004198 ! comma-shaped body is_a: UBERON:0005146 ! metanephric nephron tubule is_a: UBERON:0010535 ! primitive metanephric nephron intersection_of: UBERON:0004198 ! comma-shaped body intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0005146 name: metanephric nephron tubule def: "A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO]." [] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0005106 ! metanephric tubule is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0001231 ! nephron tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005147 name: metanephric renal vesicle def: "The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." [] synonym: "metanephric vesicle" EXACT [] is_a: UBERON:0004209 ! renal vesicle is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0004209 ! renal vesicle intersection_of: part_of UBERON:0000081 ! metanephros relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005148 name: metanephric S-shaped body def: "The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." [] is_a: UBERON:0005146 ! metanephric nephron tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium is_a: UBERON:0005332 ! mesonephric S-shaped body is_a: UBERON:0010535 ! primitive metanephric nephron intersection_of: UBERON:0004199 ! S-shaped body intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0005149 name: metanephric connecting tubule def: "The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros[GO]." [] is_a: UBERON:0005097 ! renal connecting tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0005097 ! renal connecting tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron [Term] id: UBERON:0005151 name: metanephric proximal tubule def: "The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology[GO]." [] is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0004134 ! proximal tubule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005110 ! metanephric nephron relationship: part_of UBERON:0010533 ! metanephros cortex [Term] id: UBERON:0005153 name: epithelial bud def: "A bud is a protrusion that forms from an epithelial sheet by localized folding." [] is_a: UBERON:0005157 ! epithelial fold [Term] id: UBERON:0005154 name: epithelial cord def: "A cord of epithelial cells without a lumen and usually several cells thick." [] is_a: UBERON:0000486 ! multilaminar epithelium [Term] id: UBERON:0005156 name: reproductive structure def: "An anatomical structure that is part of the reproductive system." [] synonym: "reproductive system structure" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: part_of UBERON:0000990 ! reproductive system relationship: part_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0005157 name: epithelial fold def: "An epithelial sheet bent on a linear axis." [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0005158 name: parenchyma of central nervous system def: "A parenchyma that is part of a central nervous system [Automatically generated definition]." [] synonym: "central nervous system parenchyma" EXACT [] synonym: "CNS parenchyma" EXACT [] synonym: "parenchyma of central nervous system" EXACT [] synonym: "parenchyma of CNS" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0005162 name: multi cell component structure def: "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." [] synonym: "cell part cluster" RELATED [] synonym: "multi-cell-component structure" EXACT [] synonym: "multi-cell-part structure" EXACT [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0005164 name: ascending limb of loop of Henle def: "the distal part of the loop of Henle that is impermeable to water and actively pumps sodium out of the filtrate to generate the hypertonic interstitium that drives countercurrent exchange; it consists of an initial very thin segment lined by simple squamous epithelium followed by a distal thick segment lined by simple cuboidal epithelium[MP]." [] synonym: "ascending limb" BROAD [] synonym: "ascending limb of Henle's loop" EXACT [] synonym: "distal straight tubule" RELATED [] synonym: "loop of Henle ascending limb" EXACT [] is_a: UBERON:0004135 ! distal tubule relationship: part_of UBERON:0001288 ! loop of Henle [Term] id: UBERON:0005167 name: papillary duct def: "The terminal portions of the medullary collecting ducts are the papillary ducts, which end at the renal papilla and empty into a minor calyx." [] synonym: "Bellini's duct" RELATED [] synonym: "duct of Bellini" RELATED [] synonym: "papillary duct" EXACT [] synonym: "papillary duct of kidney" EXACT [] synonym: "renal papillary duct" EXACT [] is_a: UBERON:0001232 ! collecting duct of renal tubule [Term] id: UBERON:0005168 name: interlobular vein def: "The venae stellatae join to form the interlobular veins, which pass inward between the rays, receive branches from the plexuses around the convoluted tubules, and, having arrived at the bases of the renal pyramids, join with the venae rectae" [] synonym: "interlobular veins of kidney" RELATED [] synonym: "set of interlobular veins of kidney" RELATED [] synonym: "venae interlobulares renis" EXACT [] synonym: "venae interlobulares renis" RELATED [] is_a: UBERON:0005269 ! renal cortex vein relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0005169 name: interstitial tissue def: "connective tissue between the cellular elements of a structure." [] synonym: "interstitium" EXACT [] is_a: UBERON:0003891 ! stroma [Term] id: UBERON:0005171 name: hepatic duct def: "The hepatic duct is the duct that leads from the liver to the bile duct[GO]. A duct that carries bile from the liver to the small intestine[ZFA]." [] is_a: UBERON:0002394 ! bile duct relationship: part_of UBERON:0001173 ! biliary tree [Term] id: UBERON:0005172 name: abdomen organ def: "An organ that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." [] is_a: UBERON:0005173 ! abdominal segment organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0005173 name: abdominal segment organ def: "An organ that part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." [] is_a: UBERON:0005177 ! trunk organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0005174 name: dorsal region organ def: "An organ that part of the dorsum of the organism. In vertebrates this includes the spinal cord." [] synonym: "back organ" EXACT [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0005175 name: chest organ def: "An organ that is part of a chest [Automatically generated definition]." [] is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0005176 name: tooth enamel organ def: "." [] synonym: "dental organ" EXACT [] synonym: "enamel organ" EXACT [] synonym: "odontogenic organ" RELATED [] synonym: "organum enameleum" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0005087 ! tooth placode relationship: part_of UBERON:0001091 ! calcareous tooth [Term] id: UBERON:0005177 name: trunk organ def: "An organ that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0005178 name: thoracic cavity organ def: "An organ that is in the thoracic cavity. Examples: lung, heart." [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0005179 name: pelvic region organ def: "An organ that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder." [] synonym: "pelvis organ" EXACT [] is_a: UBERON:0005173 ! abdominal segment organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0002355 ! pelvis relationship: part_of UBERON:0002355 ! pelvis [Term] id: UBERON:0005181 name: thoracic segment organ def: "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." [] synonym: "upper body organ" RELATED [] is_a: UBERON:0005177 ! trunk organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0005185 name: renal medulla collecting duct def: "A collecting duct of renal tubule that is part of a renal medulla [Automatically generated definition]." [] synonym: "kidney medulla collecting duct" EXACT [] synonym: "medullary collecting duct" EXACT [] is_a: UBERON:0001232 ! collecting duct of renal tubule intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla [Term] id: UBERON:0005186 name: outer renal medulla collecting duct def: "A collecting duct of renal tubule that is part of a outer medulla of kidney [Automatically generated definition]." [] synonym: "kidney outer medulla collecting duct" EXACT [] is_a: UBERON:0005185 ! renal medulla collecting duct intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: UBERON:0005187 name: inner renal medulla collecting duct def: "A collecting duct of renal tubule that is part of a inner medulla of kidney [Automatically generated definition]." [] synonym: "kidney inner medulla collecting duct" EXACT [] synonym: "papillary collecting duct" RELATED [] is_a: UBERON:0005185 ! renal medulla collecting duct intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: UBERON:0005194 name: thoracic vein def: "A vein that is part of a thorax [Automatically generated definition]." [] is_a: UBERON:0001638 ! vein is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0005200 name: thoracic mammary gland def: "A lactiferous gland that is located in the thoracic region/breast." [] synonym: "anterior mammary gland" RELATED [] synonym: "breast mammary gland" EXACT [] synonym: "lactiferous gland" BROAD [] synonym: "mammary gland" BROAD [] is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005175 ! chest organ intersection_of: UBERON:0001911 ! mammary gland intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0005202 name: distal straight tubule macula densa def: "A macula densa that is part of an ascending limb of loop of Henle [Automatically generated definition]." [] is_a: UBERON:0002335 ! macula densa intersection_of: UBERON:0002335 ! macula densa intersection_of: part_of UBERON:0001291 ! thick ascending limb of loop of Henle relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle relationship: part_of UBERON:0006853 ! renal cortex tubule [Term] id: UBERON:0005203 name: trachea gland def: "A gland that is part of a submucosa of trachea [Automatically generated definition]." [] synonym: "glandula trachealis" EXACT [] synonym: "tracheal gland" EXACT [] synonym: "tubular seromucous gland of trachea" RELATED [] is_a: UBERON:0002530 ! gland is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002202 ! submucosa of trachea relationship: part_of UBERON:0002202 ! submucosa of trachea [Term] id: UBERON:0005205 name: vagina stroma def: "A stroma that is part of a vagina." [] is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0005206 name: choroid plexus stroma def: "A stroma that is part of a choroid plexus [Automatically generated definition]." [] is_a: UBERON:0003891 ! stroma is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus [Term] id: UBERON:0005207 name: tonsil capsule def: "A capsule that is part of a tonsil [Automatically generated definition]." [] is_a: UBERON:0003893 ! capsule is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0003893 ! capsule intersection_of: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0005211 name: renal medulla interstitium def: "tissue surrounding the loop of Henle in the renal medulla.." [] synonym: "kidney medulla interstitium" EXACT [] synonym: "renal medullary interstitium" EXACT [] is_a: UBERON:0005215 ! kidney interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0005215 ! kidney interstitium [Term] id: UBERON:0005212 name: testis interstitial tissue def: "The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.." [] synonym: "interstitium of testis" EXACT [] synonym: "interstitium of the testis" EXACT [] synonym: "testis - interstitial" EXACT [] synonym: "testis interstitium" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005169 ! interstitial tissue is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: part_of UBERON:0000473 ! testis relationship: part_of UBERON:0000473 ! testis [Term] id: UBERON:0005213 name: outer renal medulla interstitium def: "A portion of interstitial tissue that is part of a outer medulla of kidney [Automatically generated definition]." [] synonym: "kidney outer medulla interstitium" EXACT [] synonym: "outer medullary interstitium" EXACT [] is_a: UBERON:0005211 ! renal medulla interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0005211 ! renal medulla interstitium [Term] id: UBERON:0005214 name: inner renal medulla interstitium def: "A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition]." [] synonym: "inner medullary interstitium" EXACT [] synonym: "kidney inner medulla interstitium" EXACT [] is_a: UBERON:0005211 ! renal medulla interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0005211 ! renal medulla interstitium [Term] id: UBERON:0005215 name: kidney interstitium def: "The interstitium of the kidney comprises the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances. As we define it here, the interstitium is bounded on all sides by tubular and vascular basement membranes." [] synonym: "renal interstitium" EXACT [] synonym: "renal stroma" EXACT [] synonym: "stroma of kidney" EXACT [] is_a: UBERON:0003567 ! abdomen connective tissue is_a: UBERON:0005169 ! interstitial tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0005216 name: optic eminence surface ectoderm def: "An external ectoderm that is part of a optic eminence [Automatically generated definition]." [] is_a: UBERON:0000076 ! external ectoderm intersection_of: UBERON:0000076 ! external ectoderm intersection_of: part_of UBERON:0004348 ! optic eminence relationship: part_of UBERON:0004348 ! optic eminence relationship: part_of UBERON:0005234 ! optic eminence ectoderm [Term] id: UBERON:0005233 name: medial-nasal process ectoderm def: "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." [] is_a: UBERON:0000924 ! ectoderm is_a: UBERON:0014702 ! frontonasal process epithelium intersection_of: UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0004068 ! medial nasal prominence relationship: develops_from UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0004068 ! medial nasal prominence [Term] id: UBERON:0005234 name: optic eminence ectoderm def: "An ectoderm that is part of a optic eminence [Automatically generated definition]." [] is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0004348 ! optic eminence relationship: part_of UBERON:0004348 ! optic eminence [Term] id: UBERON:0005243 name: interventricular septum endocardium def: "An endocardium that is part of a interventricular septum [Automatically generated definition]." [] synonym: "endocardium of interventricular septum" EXACT [] synonym: "interventricular septum endocardial tissue" RELATED [] is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: UBERON:0005248 name: bulbus cordis myocardium def: "A myocardium that is part of a bulbus cordis [Automatically generated definition]." [] synonym: "bulbus cordis cardiac muscle" RELATED [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0004706 ! bulbus cordis relationship: part_of UBERON:0004706 ! bulbus cordis [Term] id: UBERON:0005249 name: metanephric renal pelvis def: "A renal pelvis that is part of a metanephros." [] synonym: "metanephros pelvis" EXACT [] is_a: UBERON:0001224 ! renal pelvis intersection_of: UBERON:0001224 ! renal pelvis intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0005250 name: stomatodeum gland def: "A gland that is part of a stomodeum." [] synonym: "stomatodaeum gland" EXACT [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000930 ! stomodeum relationship: part_of UBERON:0000930 ! stomodeum [Term] id: UBERON:0005253 name: head mesenchyme def: "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." [] synonym: "cephalic mesenchyme" EXACT [] synonym: "desmocranium" RELATED [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000033 ! head intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0009142 ! entire embryonic mesenchyme [Term] id: UBERON:0005256 name: trunk mesenchyme def: "Mesenchyme that is part of a trunk." [] synonym: "trunk and cervical mesenchyme" RELATED [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000922 ! embryo intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0009142 ! entire embryonic mesenchyme [Term] id: UBERON:0005267 name: renal cortex collecting duct def: "A collecting duct of renal tubule that is part of a cortex of kidney [Automatically generated definition]." [] synonym: "kidney cortex collecting duct" EXACT [] is_a: UBERON:0001232 ! collecting duct of renal tubule intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0005268 name: renal cortex artery def: "Artery that supplies renal cortex." [] synonym: "kidney cortex artery" EXACT [] synonym: "renal cortex arterial system" RELATED [] synonym: "renal cortex artery" EXACT [] is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0005269 name: renal cortex vein def: "Artery that receives blood from the renal cortex[MP, modified]" [] synonym: "kidney cortex vein" RELATED [] synonym: "renal cortex venous system" RELATED [] is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0005270 name: renal cortex interstitium def: "A portion of interstitial tissue that is part of a cortex of kidney [Automatically generated definition]." [] synonym: "cortical stroma" RELATED [] synonym: "kidney cortex interstitium" EXACT [] is_a: UBERON:0005215 ! kidney interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0005215 ! kidney interstitium [Term] id: UBERON:0005271 name: juxtamedullary cortex def: "the part of the renal cortex nearest to the medulla." [] synonym: "inner cortex of kidney" EXACT [] synonym: "inner renal cortex" EXACT [] synonym: "juxtamedullary cortex of kidney" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0005272 name: peritubular capillary def: "In the renal system, peritubular capillaries are tiny blood vessels that travel alongside nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron. Ions and minerals that need to be saved in the body are reabsorbed into the peritubular capillaries through active transport, secondary active transport, or transcytosis. The ions that need to be excreted as waste are secreted from the capillaries into the nephron to be sent towards the bladder and out of the body. The majority of exchange through the peritubular capillaries occurs because of chemical gradients, osmosis and Na+ pumps[WP]." [] is_a: UBERON:0003527 ! kidney capillary [Term] id: UBERON:0005281 name: ventricular system of central nervous system def: "a set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP]." [] synonym: "CNS ventricular system" EXACT [] synonym: "ventral septal nucleus" RELATED [] synonym: "ventricle system" RELATED [] synonym: "ventricular system" EXACT [] synonym: "ventricular system of neuraxis" EXACT [] synonym: "ventriculi cerebri" RELATED [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0005282 name: ventricular system of brain synonym: "brain ventricular system" EXACT [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0005281 ! ventricular system of central nervous system [Term] id: UBERON:0005283 name: tela choroidea def: "A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm]." [] synonym: "tela chorioidea" RELATED [] is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0005358 ! ventricle of nervous system [Term] id: UBERON:0005284 name: brain vasculature def: "A vasculature that is part of a brain [Automatically generated definition]." [] synonym: "vasculature of brain" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0005287 name: tela choroidea of fourth ventricle def: "Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP]." [] synonym: "choroid membrane" EXACT [] synonym: "choroid membrane of fourth ventricle" EXACT [] synonym: "tela chorioidea fourth ventricle" EXACT [] synonym: "tela choroidea" BROAD [] synonym: "tela choroidea fourth ventricle" EXACT [] synonym: "tela choroidea of fourth ventricle" EXACT [] synonym: "tela choroidea ventriculi quarti" EXACT [] synonym: "tela choroidea ventriculi quarti" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005283 ! tela choroidea intersection_of: UBERON:0005283 ! tela choroidea intersection_of: part_of UBERON:0002422 ! fourth ventricle relationship: part_of UBERON:0002422 ! fourth ventricle [Term] id: UBERON:0005289 name: tela choroidea of telencephalic ventricle def: "Tela chorioidea that lines the telencephalic ventricle." [] synonym: "tela chorioidea of lateral ventricle" EXACT [] synonym: "tela chorioidea of telencephalic ventricle" EXACT [] synonym: "tela chorioidea telencephalic ventricle" EXACT [] synonym: "tela choroidea of lateral ventricle" EXACT [] synonym: "tela choroidea telencephalic ventricle" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005283 ! tela choroidea is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0005283 ! tela choroidea intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: UBERON:0005290 name: myelencephalon def: "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." [] is_a: UBERON:0004733 ! segmental subdivision of hindbrain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0005291 name: embryonic tissue def: "A portion of tissue that is part of an embryo." [] synonym: "developing tissue" RELATED [] synonym: "portion of embryonic tissue" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0000479 ! tissue intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0002050 ! embryonic structure [Term] id: UBERON:0005292 name: extraembryonic tissue def: "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." [] synonym: "extra-embryonic tissue" EXACT [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0005294 name: genital ridge def: "The precursor to the gonads." [] synonym: "crista gonadalis" RELATED [] synonym: "gonadal ridge" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0004876 ! urogenital ridge relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0004122 ! genitourinary system [Term] id: UBERON:0005295 name: sex cord def: "Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female." [] synonym: "gonad cord" RELATED [] synonym: "gonadal cord" RELATED [] synonym: "primitive sex cord" RELATED [] is_a: UBERON:0005154 ! epithelial cord is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0005294 ! genital ridge relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0005296 name: ovary sex cord def: "structures that develop from sex cords in the female. After further development they become the ovarian follicles." [] synonym: "cortical cord" RELATED [] synonym: "cortical sex cord" RELATED [] synonym: "ovary primitive sex cord" RELATED [] synonym: "ovigerous cord" EXACT [] synonym: "ovigerous cords" EXACT [] synonym: "secondary cord" RELATED [] is_a: UBERON:0004911 ! epithelium of female gonad is_a: UBERON:0005295 ! sex cord intersection_of: UBERON:0005295 ! sex cord intersection_of: part_of UBERON:0000992 ! female gonad relationship: develops_from UBERON:0010141 ! primitive sex cord of indifferent gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0005297 name: testis sex cord def: "The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP]." [] synonym: "primary sex cord" RELATED [] synonym: "testis cord" EXACT [] synonym: "testis primary sex cords" EXACT [] synonym: "testis primitive sex cord" RELATED [] is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0005295 ! sex cord intersection_of: UBERON:0005295 ! sex cord intersection_of: part_of UBERON:0000473 ! testis relationship: develops_from UBERON:0010141 ! primitive sex cord of indifferent gonad relationship: part_of UBERON:0000473 ! testis [Term] id: UBERON:0005309 name: pronephric nephron def: "A pronephric nephron is the functional unit of the pronephros[GO]." [] is_a: UBERON:0001285 ! nephron is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001285 ! nephron intersection_of: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0002120 ! pronephros [Term] id: UBERON:0005310 name: pronephric nephron tubule def: "The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO]." [] synonym: "pronephric tubule" EXACT [] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0001231 ! nephron tubule intersection_of: part_of UBERON:0005309 ! pronephric nephron relationship: part_of UBERON:0005309 ! pronephric nephron [Term] id: UBERON:0005311 name: mammary placode def: "The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO]." [] is_a: UBERON:0011814 ! non-neurogenic ectodermal placode relationship: develops_from UBERON:0008425 ! mammary ridge [Term] id: UBERON:0005316 name: endocardial endothelium def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." [] synonym: "endocardium endothelium" EXACT [] synonym: "endothelium of endocardium" EXACT [] is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium [Term] id: UBERON:0005317 name: pulmonary artery endothelium def: "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." [] synonym: "pulmonary artery endothelial tube" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery [Term] id: UBERON:0005319 name: mesonephric collecting duct def: "The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO]." [] is_a: UBERON:0001232 ! collecting duct of renal tubule is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0005320 name: mesonephric juxtaglomerular apparatus def: "The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]." [] is_a: UBERON:0002303 ! juxtaglomerular apparatus is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002303 ! juxtaglomerular apparatus intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005321 name: mesonephric smooth muscle tissue def: "." [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005322 name: mesonephric nephron def: "A nephron that is part of a mesonephros." [] synonym: "nephron of mesonephros" EXACT [] synonym: "stage IV nephron" RELATED [] is_a: UBERON:0001285 ! nephron is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001285 ! nephron intersection_of: part_of UBERON:0000080 ! mesonephros relationship: develops_from UBERON:0005323 ! mesonephric mesenchyme relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005323 name: mesonephric mesenchyme def: "Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO]." [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005324 name: mesonephric macula densa def: "The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus[GO]." [] is_a: UBERON:0002335 ! macula densa is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002335 ! macula densa intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005320 ! mesonephric juxtaglomerular apparatus [Term] id: UBERON:0005325 name: mesonephric glomerulus def: "The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO]." [] synonym: "glomerulus" BROAD [] is_a: UBERON:0000074 ! renal glomerulus intersection_of: UBERON:0000074 ! renal glomerulus intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005326 name: mesonephric glomerulus vasculature def: "The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO]." [] is_a: UBERON:0004190 ! renal glomerulus vasculature intersection_of: UBERON:0004190 ! renal glomerulus vasculature intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005325 ! mesonephric glomerulus [Term] id: UBERON:0005327 name: mesonephric glomerular epithelium def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO]." [] is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004188 ! glomerular epithelium intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron relationship: part_of UBERON:0005325 ! mesonephric glomerulus [Term] id: UBERON:0005328 name: mesonephric comma-shaped body def: "The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." [] is_a: UBERON:0004198 ! comma-shaped body is_a: UBERON:0005330 ! mesonephric nephron epithelium is_a: UBERON:0010534 ! primitive mesonephric nephron intersection_of: UBERON:0004198 ! comma-shaped body intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005329 name: mesonephric nephron tubule def: "A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros[GO]." [] synonym: "mesonephric renal tubule" EXACT [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005330 name: mesonephric nephron epithelium def: "The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO]." [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0005103 ! mesonephric epithelium intersection_of: UBERON:0004211 ! nephron epithelium intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0005331 name: mesonephric renal vesicle def: "The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." [] synonym: "mesonephric vesicle" EXACT [] is_a: UBERON:0004209 ! renal vesicle is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004209 ! renal vesicle intersection_of: part_of UBERON:0000080 ! mesonephros relationship: develops_from UBERON:0010534 ! primitive mesonephric nephron relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0005332 name: mesonephric S-shaped body def: "The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." [] is_a: UBERON:0004199 ! S-shaped body is_a: UBERON:0010534 ! primitive mesonephric nephron intersection_of: UBERON:0004199 ! S-shaped body intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0005333 name: mammary bud def: "Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord[GO]. produced along the length of the embryonic mammary ridge these buds represent the future locations of the mammary glands. Invagination of ectoderm at each bud leads to the development of epithelial diverticula, later maturing as lactiferous ducts[TFD]." [] synonym: "mammary gland bud" EXACT [] synonym: "milk bud" RELATED [] is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0005311 ! mammary placode relationship: part_of UBERON:0000076 ! external ectoderm [Term] id: UBERON:0005337 name: outflow tract of ventricle def: "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." [] synonym: "heart ventricle outflow tract" EXACT [] synonym: "outflow part of ventricle" EXACT [] synonym: "ventricular outflow tract" EXACT [] is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0005338 name: outflow tract aortic component def: "An outflow tract that is part of a aorta." [] is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0005357 name: brain ependyma def: "An ependyma that is part of a brain ventricle." [] synonym: "ependyma of ventricular system of brain" EXACT [] is_a: UBERON:0004670 ! ependyma is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0004670 ! ependyma intersection_of: part_of UBERON:0004086 ! brain ventricle relationship: part_of UBERON:0004086 ! brain ventricle [Term] id: UBERON:0005358 name: ventricle of nervous system synonym: "region of wall of ventricular system of neuraxis" RELATED [] is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0005359 name: spinal cord ependyma def: "An ependyma that is part of a spinal cord." [] synonym: "ependyma of central canal of spinal cord" EXACT [] synonym: "spinal cord ependymal layer" EXACT [] synonym: "spinal cord ventricular layer" RELATED [] is_a: UBERON:0004670 ! ependyma is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0004670 ! ependyma intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002291 ! central canal of spinal cord [Term] id: UBERON:0005366 name: olfactory lobe def: "Olfactory apparatus on the lower surface of the frontal lobe of the brain. It consists of the olfactory bulb, tract, and trigone[BTO]." [] is_a: UBERON:0002791 ! regional part of telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0005376 name: olfactory bulb external plexiform layer def: "Cytoarchitectural part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer. The EPL is mostly neuropil composed almost entirely of mitral and tulfted cell dendrites and granule cell dendrites and their synaptic inputs." [] synonym: "EPL" RELATED [] synonym: "external plexiform layer" BROAD [] synonym: "external plexiform layer of the olfactory bulb" RELATED [] synonym: "olfactory bulb main external plexiform layer" EXACT [] is_a: UBERON:0009950 ! olfactory bulb plexiform layer [Term] id: UBERON:0005377 name: olfactory bulb glomerular layer def: "The glomerular layer is the most superficial layer, consisting of mitral cell dendritic arborizations (glomeruli), olfactory nerve fibers, and periglomerular cells. Periglomerular cells contact multiple mitral cell dendrites within the glomeruli and provide lateral inhibition of neighboring glomeruli while allowing excitation of a specific mitral cell dendritic tree. Each mitral cell is contacted by at least 1000 olfactory nerve fibers[BTO]. Portion of tissue which is located in between the primary olfactory fiber layer and the external cellular layer of the olfactory bulb[ZFA]." [] synonym: "glomerular layer" BROAD [] synonym: "glomerular layer of the olfactory bulb" RELATED [] synonym: "olfactory bulb main glomerulus" EXACT [] synonym: "stratum glomerulosum bulbi olfactorii" EXACT [] is_a: UBERON:0004001 ! olfactory bulb layer [Term] id: UBERON:0005384 name: nasal cavity epithelium def: "An epithelium that is part of a nasal cavity [Automatically generated definition]." [] synonym: "nasal epithelium" EXACT [] synonym: "nasal mucosa" RELATED [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0010371 ! ecto-epithelium relationship: part_of UBERON:0001826 ! nasal cavity mucosa [Term] id: UBERON:0005388 name: photoreceptor array def: "An array of photoreceptors and any supporting cells found in an eye." [] synonym: "light-sensitive tissue" EXACT [] is_a: UBERON:0000479 ! tissue relationship: part_of UBERON:0000970 ! eye [Term] id: UBERON:0005389 name: transparent eye structure synonym: "lens" NARROW [] is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0000970 ! eye [Term] id: UBERON:0005396 name: carotid artery segment def: "One of: the common carotid artery, or its branches, the external and internal carotid arteries." [] synonym: "carotid artery" EXACT [] synonym: "common carotid arterial subdivision" RELATED [] synonym: "subdivision of common carotid artery" EXACT [] is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0005398 name: female reproductive gland def: "A sex gland that is part of a female reproductive system." [] is_a: UBERON:0003937 ! sex gland is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003937 ! sex gland intersection_of: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0003134 ! female reproductive organ [Term] id: UBERON:0005399 name: male reproductive gland def: "A sex gland that is part of a male reproductive system." [] is_a: UBERON:0003937 ! sex gland is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0003937 ! sex gland intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0005401 name: cerebral hemisphere grey matter synonym: "cerebral gray matter" EXACT [] synonym: "cerebral grey matter" EXACT [] is_a: UBERON:0011300 ! gray matter of telencephalon intersection_of: UBERON:0002020 ! gray matter of neuraxis intersection_of: part_of UBERON:0001869 ! cerebral hemisphere relationship: part_of UBERON:0001869 ! cerebral hemisphere [Term] id: UBERON:0005406 name: perirenal fat def: "The adipose capsule of kidney (or perinephric fat or perirenal fat) is a structure between the renal fascia and renal capsule, and may be regarded as a part of the latter. A different structure, the pararenal fat, is the adipose tissue superficial to the renal fascia." [] synonym: "adipose capsule of kidney" RELATED [] synonym: "capsula adiposa renis" RELATED [] synonym: "fatty capsule of kidney" RELATED [] synonym: "perinephric fat" RELATED [] synonym: "periphrenic fascia" RELATED [] synonym: "perirenal fascia" EXACT [] synonym: "perirenal fascia" RELATED [] synonym: "perirenal fat capsule" RELATED [] synonym: "perirenal fat pad" RELATED [] is_a: UBERON:0001013 ! adipose tissue [Term] id: UBERON:0005409 name: gastrointestinal system synonym: "alimentary system" RELATED [] synonym: "alimentary tract" RELATED [] synonym: "gastro-intestinal system" RELATED [] synonym: "gastrointestinal (GI) tract" RELATED [] synonym: "gastrointestinal system" RELATED [] synonym: "gastrointestinal tract" RELATED [] synonym: "GI tract" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0005423 name: developing anatomical structure synonym: "developing structure" RELATED [] synonym: "developmental structure" RELATED [] synonym: "developmental tissue" RELATED [] is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0005424 name: presumptive retinal pigmented epithelium def: "Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium." [] synonym: "future pigmented layer" RELATED [] synonym: "future pigmented retinal epithelium" RELATED [] synonym: "future PRE" RELATED [] synonym: "optic cup outer layer" EXACT [] synonym: "outer layer optic cup" EXACT [] synonym: "presumptive pigmented epithelia" EXACT [] synonym: "presumptive pigmented epithelium" RELATED [] is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye relationship: part_of UBERON:0003072 ! optic cup [Term] id: UBERON:0005426 name: lens vesicle def: "Portion of tissue that gives rise to the lens." [] synonym: "hollow lens vesicle" NARROW [] synonym: "solid lens vesicle" NARROW [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0003073 ! lens placode [Term] id: UBERON:0005427 name: corneal primordium def: "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0001048 ! primordium is_a: UBERON:0010312 ! immature eye is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0005428 name: vagal neural crest def: "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." [] synonym: "post-otic neural crest" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0002342 ! neural crest [Term] id: UBERON:0005432 name: aortic sac def: "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001637 ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0004363 ! aortic arch relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0005477 name: stomach fundus epithelium def: "A simple columnar epithelium that is part of a fundus of stomach." [] synonym: "epithelium of fundus of stomach" EXACT [] synonym: "gastric epithelium of fundus" EXACT [] synonym: "gastric fundus epithelium" EXACT [] is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0000485 ! simple columnar epithelium intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach [Term] id: UBERON:0005495 name: midbrain lateral wall synonym: "lateral wall mesencephalon" RELATED [] synonym: "lateral wall midbrain" EXACT [] is_a: UBERON:0005496 ! neural tube lateral wall relationship: part_of UBERON:0001891 ! midbrain [Term] id: UBERON:0005496 name: neural tube lateral wall def: "Portion of tissue on the side of the lumen of the neural tube." [] synonym: "lateral wall neural tube" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0005497 name: non-neural ectoderm synonym: "epidermal ectoderm" NARROW [] synonym: "epithelial ectoderm" NARROW [] synonym: "non neural ectoderm" EXACT [] synonym: "surface ectoderm" RELATED [] synonym: "ventral ectoderm" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0000924 ! ectoderm [Term] id: UBERON:0005498 name: primitive heart tube def: "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." [] synonym: "early primitive heart tube" NARROW [] synonym: "primitive heart tube" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0004291 ! heart rudiment relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0005501 name: rhombomere lateral wall def: "A neural tube lateral wall that is part of a rhombomere." [] is_a: UBERON:0005496 ! neural tube lateral wall intersection_of: UBERON:0005496 ! neural tube lateral wall intersection_of: part_of UBERON:0001892 ! rhombomere relationship: part_of UBERON:0001892 ! rhombomere [Term] id: UBERON:0005562 name: thymus primordium def: "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID]." [] synonym: "thymic primordium" EXACT [] synonym: "thymic rudiment" EXACT [] is_a: UBERON:0001048 ! primordium is_a: UBERON:0003351 ! pharyngeal epithelium relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm relationship: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0002405 ! immune system relationship: part_of UBERON:0003295 ! pharyngeal gland [Term] id: UBERON:0005564 name: gonad primordium def: "Portion of tissue that gives rise to the immature gonad." [] synonym: "gonadal primordium" EXACT [] synonym: "undifferentiated gonad" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0001048 ! primordium is_a: UBERON:0005156 ! reproductive structure relationship: part_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0005565 name: facio-acoustic neural crest def: "Cranial neural crest that gives rise to the facio-acoustic ganglion." [] synonym: "facio acoustic neural crest" EXACT [] is_a: UBERON:0003099 ! cranial neural crest is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 ! migrating mesenchyme population relationship: develops_from UBERON:0003849 ! mesencephalic neural crest [Term] id: UBERON:0005594 name: head somite def: "Somite located in the head region, caudal to the otic vesicle" [] synonym: "cranial somite" RELATED [] synonym: "occipital somite" EXACT [] is_a: UBERON:0002329 ! somite is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0002329 ! somite intersection_of: develops_from UBERON:0009617 ! head paraxial mesoderm relationship: develops_from UBERON:0009617 ! head paraxial mesoderm relationship: part_of UBERON:0009617 ! head paraxial mesoderm [Term] id: UBERON:0005597 name: lung primordium def: "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." [] synonym: "lateral diverticula" RELATED [] synonym: "lung endoderm" RELATED [] is_a: UBERON:0001048 ! primordium relationship: develops_from UBERON:0001041 ! foregut relationship: part_of UBERON:0008947 ! respiratory primordium [Term] id: UBERON:0005598 name: trunk somite def: "A somite that is part of a trunk." [] is_a: UBERON:0002329 ! somite intersection_of: UBERON:0002329 ! somite intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0005602 name: dorsal mesogastrium def: "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum." [] synonym: "dorsal mesentery" RELATED [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003281 ! mesentery of stomach relationship: part_of UBERON:0002296 ! dorsal mesentery relationship: part_of UBERON:0003281 ! mesentery of stomach [Term] id: UBERON:0005629 name: vascular plexus def: "a vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part." [] synonym: "plexus vasculosus" EXACT [] is_a: UBERON:0002049 ! vasculature relationship: part_of UBERON:0001009 ! circulatory system [Term] id: UBERON:0005631 name: extraembryonic membrane def: "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." [] is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0004716 ! conceptus [Term] id: UBERON:0005636 name: caecum epithelium def: "An epithelium that is part of a caecum." [] is_a: UBERON:0000397 ! colonic epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: UBERON:0005637 name: pyloric region epithelium def: "An epithelium that is part of a pylorus." [] is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus [Term] id: UBERON:0005638 name: anterior chamber epithelium def: "An epithelium that is part of a anterior chamber of eyeball." [] is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 ! anterior chamber of eyeball [Term] id: UBERON:0005641 name: otocyst epithelium def: "An epithelium that is part of a ear vesicle." [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003051 ! ear vesicle relationship: part_of UBERON:0003051 ! ear vesicle [Term] id: UBERON:0005656 name: lens vesicle epithelium def: "An epithelium that is part of a lens vesicle." [] is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0005426 ! lens vesicle relationship: part_of UBERON:0005426 ! lens vesicle [Term] id: UBERON:0005660 name: 2nd arch ectoderm def: "An ectoderm that is part of a pharyngeal arch 2." [] synonym: "2nd pharyngeal arch ectoderm" EXACT [] is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2 relationship: part_of UBERON:0003066 ! pharyngeal arch 2 [Term] id: UBERON:0005664 name: 2nd arch endoderm def: "An endoderm that is part of a pharyngeal arch 2." [] synonym: "2nd pharyngeal arch endoderm" EXACT [] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2 relationship: part_of UBERON:0003066 ! pharyngeal arch 2 [Term] id: UBERON:0005677 name: caecum mesentery def: "A mesentery that is part of a caecum." [] is_a: UBERON:0003396 ! mesentery of colon intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: UBERON:0005685 name: midgut dorsal mesentery def: "A dorsal mesentery that is part of a midgut." [] is_a: UBERON:0002296 ! dorsal mesentery intersection_of: UBERON:0002296 ! dorsal mesentery intersection_of: part_of UBERON:0001045 ! midgut relationship: part_of UBERON:0001045 ! midgut [Term] id: UBERON:0005686 name: caecum dorsal mesentery def: "A dorsal mesentery that is part of a caecum." [] is_a: UBERON:0002296 ! dorsal mesentery intersection_of: UBERON:0002296 ! dorsal mesentery intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: UBERON:0005689 name: 2nd arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 2." [] synonym: "2nd branchial arch mesenchyme" RELATED [] synonym: "2nd pharyngeal arch mesenchyme" EXACT [] synonym: "pharyngeal arch 2 mesenchyme" RELATED [] is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0003066 ! pharyngeal arch 2 relationship: part_of UBERON:0003066 ! pharyngeal arch 2 [Term] id: UBERON:0005702 name: optic eminence mesenchyme def: "Mesenchyme that is part of a optic eminence." [] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0004348 ! optic eminence relationship: part_of UBERON:0004348 ! optic eminence [Term] id: UBERON:0005711 name: foregut duodenum mesentery def: "A mesentery of duodenum that is part of a foregut." [] is_a: UBERON:0003397 ! mesentery of duodenum is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003397 ! mesentery of duodenum intersection_of: part_of UBERON:0001041 ! foregut relationship: develops_from UBERON:0011642 ! oral epithelium from ectoderm relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0005712 name: midgut duodenum mesentery def: "A mesentery of duodenum that is part of a midgut." [] is_a: UBERON:0003284 ! mesentery of midgut is_a: UBERON:0003397 ! mesentery of duodenum is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003397 ! mesentery of duodenum intersection_of: part_of UBERON:0001045 ! midgut relationship: develops_from UBERON:0011642 ! oral epithelium from ectoderm relationship: part_of UBERON:0001045 ! midgut [Term] id: UBERON:0005720 name: hindbrain venous system def: "A venous system that is part of a hindbrain." [] synonym: "rhombencephalon venous system" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004582 ! venous system intersection_of: UBERON:0004582 ! venous system intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0005721 name: pronephric mesoderm def: "A mesoderm that has_potential_to_develop_into a pronephros." [] synonym: "pronephric anlage" RELATED [] synonym: "pronephric bulge" RELATED [] synonym: "pronephric mesenchyme" RELATED [] synonym: "pronephric primordium" RELATED [] is_a: UBERON:0000926 ! mesoderm is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0007297 ! presumptive pronephric mesoderm relationship: part_of UBERON:0003064 ! intermediate mesoderm [Term] id: UBERON:0005725 name: olfactory system def: "A sensory system that is capable of olfacttion (the sensory perception of smell)." [] is_a: UBERON:0005726 ! chemosensory system [Term] id: UBERON:0005726 name: chemosensory system is_a: UBERON:0001032 ! sensory system [Term] id: UBERON:0005728 name: extraembryonic mesoderm def: "." [] synonym: "extra-embryonic mesoderm" EXACT [] synonym: "extraembryonic mesenchyme" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: develops_from UBERON:0008780 ! inner cell mass derived epiblast [Term] id: UBERON:0005734 name: tunica adventitia of blood vessel def: "The outermost layer of a blood vessel, composed mainly of fibrous tissue." [] synonym: "adventitia externa" EXACT [] synonym: "external coat" RELATED [] synonym: "tunica adventitia" EXACT [] synonym: "tunica adventitia of vessel" EXACT [] synonym: "tunica adventitia vasorum" RELATED [] synonym: "tunica externa vasorum" RELATED [] is_a: UBERON:0004797 ! blood vessel layer is_a: UBERON:0005742 ! adventitia [Term] id: UBERON:0005740 name: tunica intima of artery def: "A tunica intima that is part of a artery." [] synonym: "arterial intima" EXACT [] synonym: "tunica interna (intima)(arteriae)" EXACT [] is_a: UBERON:0002523 ! tunica intima intersection_of: UBERON:0002523 ! tunica intima intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0000415 ! artery wall relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0005742 name: adventitia def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." [] synonym: "tunica advetitia" NARROW [] synonym: "tunica externa" NARROW [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0005744 name: bone foramen def: "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." [] synonym: "foramen" BROAD [] synonym: "foramens@fr" EXACT [] synonym: "foramina@fr" EXACT [] is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element [Term] id: UBERON:0005749 name: glomerular tuft def: "the capillary loops of the kidney that normally function as a filtration unit[MP]. ...Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus[GudMap]." [] synonym: "glomerular capillary tuft" RELATED [] synonym: "glomerulus" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0001230 ! glomerular capsule [Term] id: UBERON:0005750 name: glomerular parietal epithelium def: "A single layer of simple squamous epithelium in the glomerular capsule. Does not function in filtration[UBERON]. outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium[MP]" [] synonym: "Bowman's parietal epithelium" EXACT [] synonym: "capsular epithelium" EXACT [] synonym: "glomerular capsule parietal layer" EXACT [] synonym: "outer layer of glomerular capsule" EXACT [] synonym: "parietal capsular epithelium" EXACT [] synonym: "parietal epithelial layer" EXACT [] synonym: "parietal epithelium of Bowman's capsule" EXACT [] synonym: "parietal layer of Bowman capsule" EXACT [] synonym: "parietal layer of Bowman's capsule" EXACT [] synonym: "parietal layer of glomerular capsule" EXACT [] synonym: "renal glomerular capsule epithelium" EXACT [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0004188 ! glomerular epithelium relationship: part_of UBERON:0001230 ! glomerular capsule [Term] id: UBERON:0005751 name: visceral layer of glomerular capsule def: "The inner, or visceral, layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer, or parietal, layer by the capsular (Bowman's) space[BTO]. Lies just above the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]" [] synonym: "Bowman's visceral epithelium" EXACT [] synonym: "glomerular capsule visceral layer" EXACT [] synonym: "inner epithelial layer of Bowman's capsule" EXACT [] synonym: "podocyte layer of Bowman's capsule" EXACT [] synonym: "visceral epithelium of Bowman's capsule" EXACT [] synonym: "visceral layer of Bowman's capsule" EXACT [] synonym: "visceral layer of glomerular capsule" EXACT [] is_a: UBERON:0004211 ! nephron epithelium relationship: part_of UBERON:0001230 ! glomerular capsule [Term] id: UBERON:0005753 name: caudal part of nephrogenic cord def: "the metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm." [] synonym: "caudal portion of nephrogenic cord" EXACT [] synonym: "caudal region of nephrogenic cord" EXACT [] synonym: "rear part of nephrogenic cord" EXACT [] synonym: "rear portion of nephrogenic cord" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0004875 ! nephrogenic cord [Term] id: UBERON:0005754 name: rostral part of nephrogenic cord def: "The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros." [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0004875 ! nephrogenic cord [Term] id: UBERON:0005760 name: urorectal septum def: "The ridge of mesoderm covered with endoderm that in the early developing embryo partitions the endodermal cloaca into the primary urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally); the urorectal septum eventually fuses with the cloacal membrane, dividing it into a dorsal anal membrane and a larger ventral urogenital membrane - this area of fusion is represented in the adult by the perineal body[MP]." [] synonym: "cloacal septum" RELATED [] synonym: "septum urorectale" EXACT [] synonym: "urorectal fold" EXACT [] synonym: "urorectal membrane" EXACT [] is_a: UBERON:0003037 ! septum is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0012361 ! internal anal region [Term] id: UBERON:0005800 name: segment of aorta def: "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." [] synonym: "aortic segment" EXACT [] is_a: UBERON:0000063 ! organ segment is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0005805 name: dorsal aorta def: "The artery in vertebrate embryos that transports blood from the aortic arches to the trunk and limbs. In adult fish it is a major artery that carries oxygenated blood from the efferent branchial arteries to branches that supply the body organ. In adult tetrapods it arises from the systemic arch[BTO]. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once[GO]. Each primitive aorta receives anteriorly a vein 'the vitelline vein' from the yolk-sac, and is prolonged backward on the lateral aspect of the notochord under the name of the dorsal aorta. The dorsal aortae give branches to the yolk-sac, and are continued backward through the body-stalk as the umbilical arteries to the villi of the chorion. The two dorsal aortae combine to become the descending aorta in later development[WP]." [] synonym: "aortae dorsales" RELATED [] synonym: "DA" EXACT [] synonym: "dorsal aorta root" RELATED [] synonym: "dorsal aortic root" RELATED [] synonym: "dorsal aort" RELATED [] is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: develops_from UBERON:0001917 ! endothelium of artery relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: part_of UBERON:0002201 ! vasculature of trunk [Term] id: UBERON:0005808 name: bone tissue of long bone def: "A bone tissue that is part of a long bone." [] is_a: UBERON:0002481 ! bone tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: part_of UBERON:0002495 ! long bone relationship: part_of UBERON:0002495 ! long bone [Term] id: UBERON:0005856 name: developing mesenchymal condensation def: "A delimited region of dense mesenchyme within looser mesenchyme." [] synonym: "mesenchyme condensation" EXACT [] is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0011585 ! cell condensation [Term] id: UBERON:0005863 name: cartilaginous condensation def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [] synonym: "cartilage condensation" EXACT [] synonym: "cartilagenous condensation" EXACT [] synonym: "chondrogenic condensation" EXACT [] is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: develops_from UBERON:0005866 ! pre-cartilage condensation relationship: part_of UBERON:0004288 ! skeleton [Term] id: UBERON:0005865 name: pre-muscle condensation synonym: "pre muscle mass" EXACT [] synonym: "premuscle mass" EXACT [] is_a: UBERON:0005856 ! developing mesenchymal condensation [Term] id: UBERON:0005866 name: pre-cartilage condensation def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [] synonym: "pre-chondrogenic condensation" EXACT [] synonym: "precartilage condensation" EXACT [] synonym: "precartilagenous condensation" EXACT [] synonym: "prechondrogenic condensation" EXACT [] is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: part_of UBERON:0004288 ! skeleton [Term] id: UBERON:0005872 name: 1st arch pharyngeal cleft def: "A groove that is situated between the 1st and 2nd pharyngeal arch." [] synonym: "1st arch branchial groove" EXACT [] synonym: "1st arch groove ectoderm" EXACT [] synonym: "1st pharyngeal cleft" RELATED [] synonym: "1st pharyngeal groove" EXACT [] synonym: "1st pharyngeal groove ectoderm" EXACT [] synonym: "branchial groove of 1st arch" EXACT [] is_a: UBERON:0005879 ! pharyngeal cleft [Term] id: UBERON:0005876 name: undifferentiated genital tubercle def: "A genital tubercle is a body of tissue present in the development of the urinary and reproductive organs. It forms in the ventral, caudal region of mammalian embryos of both sexes, and eventually develops into a phallus. In the human fetus the genital tubercle develops around week 4 of gestation, and by week 9 becomes recognizably either a clitoris or penis. This should not be confused with the sinus tubercle which is a proliferation of endoderm induced by paramesonephic ducts. Even after the phallus is developed, the term genital tubercle remains, but only as the terminal end of it[2], which develops into either the glans penis or the glans clitoridis. The genital tubercle is sensitive to dihydrotestosterone and rich in 5-alpha-reductase, so that the amount of fetal testosterone present after the second month is a major determinant of phallus size at birth.[WP]." [] synonym: "genital tubercle" RELATED [] synonym: "phallic tubercle" RELATED [] synonym: "tuberculum genitale" RELATED [] synonym: "tuberculum phallicum" RELATED [] synonym: "undifferentiated genital tubercle" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0004874 ! somatopleure relationship: part_of UBERON:0009196 ! indifferent external genitalia [Term] id: UBERON:0005879 name: pharyngeal cleft def: "the counterpart of a branchial pouch on the ectodermal side. The first pharyngeal groove produces the external auditory meatus.[2] The rest (2, 3, and 4) are overlapped by the growing 2nd pharyngeal arch, and form the floor of the depression termed the cervical sinus, which opens ventrally, and finally obliterated[WP]." [] synonym: "branchial cleft" RELATED [] synonym: "branchial groove" RELATED [] synonym: "gill cleft" NARROW [] synonym: "Kiemenspalten" RELATED [] synonym: "pharyngeal groove" EXACT [] synonym: "pharyngeal groove ectoderm" EXACT [] synonym: "sulcus pharyngei" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006846 ! surface groove is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0005883 name: neural tube lateral wall mantle layer is_a: UBERON:0004061 ! neural tube mantle layer relationship: part_of UBERON:0005496 ! neural tube lateral wall [Term] id: UBERON:0005891 name: coelomic epithelium def: "The epithelial lining of the surface of the coelom." [] synonym: "celomic epithelium" EXACT [] synonym: "germinal epithelium of Waldeyer" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0011997 ! coelom [Term] id: UBERON:0005903 name: duct of seminal vesicle def: "Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP]." [] synonym: "ductus excretorius (vesicula seminalis)" EXACT [] synonym: "ductus excretorius glandulae vesiculosae" EXACT [] synonym: "ductus excretorius glandulae vesiculosae" RELATED [] synonym: "excretory duct of seminal gland" EXACT [] synonym: "seminal vesicle duct" EXACT [] is_a: UBERON:0005904 ! duct of male reproductive system intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle [Term] id: UBERON:0005904 name: duct of male reproductive system def: "Any of the ducts that are part of a male reproductive system." [] is_a: UBERON:0000058 ! duct is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0005906 name: serous sac def: "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]" [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0005908 name: conjunctival sac def: "Serous sac, which has as parts the conjunctiva and the cavity of conjunctiva. Examples: There are only two conjunctival sacs, the right and the left.[FMA]" [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005906 ! serous sac relationship: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0005910 name: transitional epithelium def: "Multilaminar epithelium, which of consists of more than one layer of epithelial cells, in contact with a basement membrane, that can undergo distention and contraction without losing its integrity and consistency. Examples: urothelium.[FMA]" [] synonym: "epithelium transitionale" EXACT [] synonym: "urothelium" NARROW [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium [Term] id: UBERON:0005911 name: endo-epithelium def: "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]" [] synonym: "endoderm-derived epithelium" EXACT [] synonym: "endoepithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0000925 ! endoderm [Term] id: UBERON:0005913 name: zone of bone organ synonym: "bone organ zone" EXACT [] is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0001474 ! bone element [Term] id: UBERON:0005932 name: bulb of hair follicle def: "The lower segment of the hair that circles the dermal papilla and the hair matrix." [] synonym: "coat hair bulb" NARROW [] synonym: "hair bulb" EXACT [] synonym: "hair follicle bulb" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002073 ! hair follicle [Term] id: UBERON:0005933 name: hair root sheath is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0005932 ! bulb of hair follicle [Term] id: UBERON:0005941 name: hair inner root sheath def: "A multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle[MP]." [] synonym: "hair follicle inner root sheath" EXACT [] synonym: "inner root sheath" RELATED [] synonym: "inner root sheath of hair follicle" EXACT [] synonym: "inner sheath of hair follicle" EXACT [] synonym: "internal root sheath of hair follicle" EXACT [] is_a: UBERON:0005933 ! hair root sheath [Term] id: UBERON:0005942 name: hair outer root sheath def: "It surrounds the hair follicle like a sleeve all the way to the bulb. The outer root sheath is essentially a stratified epithelium that is contiguous with the epidermis." [] synonym: "external root sheath of hair follicle" EXACT [] synonym: "hair follicle outer root sheath" EXACT [] synonym: "ORS" RELATED [] synonym: "outer root sheath" RELATED [] synonym: "outer root sheath of hair follicle" EXACT [] is_a: UBERON:0005933 ! hair root sheath [Term] id: UBERON:0005946 name: outflow tract of atrium def: "An outflow tract that is part of a cardiac atrium." [] synonym: "outflow part of atrium" EXACT [] is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0005953 name: outflow part of right ventricle def: "Outflow part of ventricle which is continuous with the pulmonary trunk[FNA]. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery[WP]." [] synonym: "conus arteriosus (infundibulum)" EXACT [] synonym: "infundibulum" BROAD [] synonym: "infundibulum of right ventricle" EXACT [] synonym: "outflow tract of right ventricle" EXACT [] synonym: "pulmonary conus" EXACT [] synonym: "right ventricular outflow tract" EXACT [] synonym: "RVOT" EXACT [] is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: develops_from UBERON:0009889 ! secondary heart field relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0005956 name: outflow part of left ventricle def: "Outflow part of ventricle which is continuous with the aorta[FMA]. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." [] synonym: "aortic vestibule" EXACT [] synonym: "left ventricular outflow" EXACT [] synonym: "left ventricular outflow tract" EXACT [] synonym: "LVOT" EXACT [] synonym: "outflow tract of left ventricle" EXACT [] synonym: "vestibulum aortae" EXACT [] is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0005969 name: reticulum trabeculare def: "a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris[GO]. The trabecular meshwork is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). The tissue is spongy and lined by trabeculocytes; it allows fluid to drain into a set of tubes called Schlemm's canal flowing into the blood system[WP]. A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.[GAID] the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates[MP]." [] synonym: "cribiform ligament" RELATED [] synonym: "Hueck's ligament" RELATED [] synonym: "iridis" RELATED [] synonym: "ligamentum peactin-tum iridis" RELATED [] synonym: "ligamentum pectinatum" RELATED [] synonym: "ligamentum pectinatum anguli iridocornealis" RELATED [] synonym: "ligamentum pectinatum iridis" RELATED [] synonym: "pectinate ligament" RELATED [] synonym: "pectinate ligament of iris" RELATED [] synonym: "reticulum trabeculare sclerae" RELATED [] synonym: "scleral trabeculae" RELATED [] synonym: "scleral trabecular" RELATED [] synonym: "scleral trabecule" RELATED [] synonym: "scribiform ligament" RELATED [] synonym: "trabecular mesh" RELATED [] synonym: "trabecular meshwork" RELATED [] synonym: "trabecular meshwork of the eye" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0003956 ! aqueous drainage system [Term] id: UBERON:0005971 name: amniotic fold def: "A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong]." [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0004874 ! somatopleure [Term] id: UBERON:0005983 name: heart layer def: "the laminar structure of the heart" [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0005985 name: coronary vessel def: "any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [] is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000055 ! vessel intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0005986 name: left branch of atrioventricular bundle def: "Subdivision of conducting system of heart which enters the septal myocardium of left ventricle and is continuous with the anterior, septal and posterior divisions of the left branch of the atrioventricular bundle[FMA]. the left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber[MP]." [] synonym: "crus sinistrum (fasciculi atrioventricularis)" EXACT [] synonym: "left bundle branch" EXACT [] synonym: "left bundle branch of bundle of His" EXACT [] synonym: "left bundle of atrioventricular bundle" EXACT [] synonym: "left crus of atrioventricular bundle" EXACT [] synonym: "left posterior branch" EXACT [] synonym: "left posterior bundle" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart relationship: part_of UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0005987 name: right branch of atrioventricular bundle def: "Subdivision of conducting system of heart which enters the septal myocardium of right ventricle to reach the anterior papillary muscle and then subendocardially to the apex of the heart[FMA]. the right branch of the atrioventricular bundle that separates just below the bundle of His, descends the septal wall of the right ventricle and connects to the terminal Purkinje fibers[MP]." [] synonym: "crus dextrum (fasciculi atrioventricularis)" EXACT [] synonym: "right bundle" EXACT [] synonym: "right bundle branch" EXACT [] synonym: "right bundle branch of bundle of His" EXACT [] synonym: "right right crus of atrioventricular bundle" EXACT [] synonym: "right ventricular bundle" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart relationship: part_of UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0006003 name: integumentary adnexa def: "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." [] synonym: "adnexae cutis" RELATED [] synonym: "skin adnexa" RELATED [] synonym: "skin appendage" RELATED [] is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0006004 name: hair follicle matrix region def: "the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [] synonym: "germinal matrix of hair bulb" EXACT [] synonym: "lower part of bulb of hair follicle" EXACT [] synonym: "lower zone of bulb of hair follicle" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0005932 ! bulb of hair follicle [Term] id: UBERON:0006008 name: fibrous ring of heart def: "The right and left fibrous rings of heart (anulus fibrosus cordis) surround the atrioventricular and arterial orifices, and are stronger upon the left than on the right side of the heart. The right fibrous ring is known as the anulus fibrosus dexter cordis, and the left is known as the anulus fibrosus sinister cordis. The atrioventricular rings serve for the attachment of the muscular fibers of the atria and ventricles, and for the attachment of the bicuspid and tricuspid valves. The left atrioventricular ring is closely connected, by its right margin, with the aortic arterial ring; between these and the right atrioventricular ring is a triangular mass of fibrous tissue, the trigonum fibrosum, which represents the os cordis seen in the heart of some of the larger animals, as the ox and elephant. Lastly, there is the tendinous band, already referred to, the posterior surface of the conus arteriosus. The fibrous rings surrounding the arterial orifices serve for the attachment of the great vessels and semilunar valves, they are known as The aortic annulus. Each ring receives, by its ventricular margin, the attachment of some of the muscular fibers of the ventricles; its opposite margin presents three deep semicircular notches, to which the middle coat of the artery is firmly fixed. The attachment of the artery to its fibrous ring is strengthened by the external coat and serous membrane externally, and by the endocardium internally. From the margins of the semicircular notches the fibrous structure of the ring is continued into the segments of the valves. The middle coat of the artery in this situation is thin, and the vessel is dilated to form the sinuses of the aorta and pulmonary artery." [] synonym: "annulus fibrosus cordis" RELATED [] synonym: "anulus fibrosus cordis" RELATED [] synonym: "anulus fibrosus of heart" EXACT [] synonym: "aortic annulus" RELATED [] synonym: "atrioventricular ring" RELATED [] synonym: "coronary tendon" RELATED [] synonym: "fibrous ring of heart" RELATED [] synonym: "Lower's ring" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006444 ! annulus fibrosus intersection_of: UBERON:0006444 ! annulus fibrosus intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0006082 name: fundus of urinary bladder def: "The base or posterior surface of the urinary bladder contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice." [] synonym: "base of urinary bladder" EXACT [] synonym: "fundus of bladder" BROAD [] synonym: "fundus vesicae" EXACT [] synonym: "urinary bladder base" EXACT [] synonym: "urinary bladder fundus" EXACT [] synonym: "urinary bladder fundus region" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: develops_from UBERON:0005760 ! urorectal septum relationship: develops_from UBERON:0009845 ! urogenital sinus mesenchyme relationship: part_of UBERON:0001255 ! urinary bladder [Term] id: UBERON:0006098 name: basal nuclear complex def: "The deep nuclei of telencephalic origin found in the basal region of the forebrain" [] synonym: "basal ganglia" RELATED [] synonym: "basal ganglia (anatomic)" RELATED [] synonym: "basal nuclei" EXACT [] synonym: "basal nuclei of the forebrain" EXACT [] synonym: "corpus striatum (Savel'ev)" RELATED [] synonym: "ganglia basales" RELATED [] is_a: UBERON:0002780 ! regional part of forebrain relationship: part_of UBERON:0002743 ! basal forebrain [Term] id: UBERON:0006173 name: pronephric proximal tubule def: "A pronephric nephron tubule is an epithelial tube that is part of the pronephros" [] synonym: "pronephros proximal tubule" EXACT [] is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0004134 ! proximal tubule intersection_of: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0005309 ! pronephric nephron [Term] id: UBERON:0006175 name: pronephric distal tubule def: "A pronephric nephron tubule is an epithelial tube that is part of the pronephros" [] is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0004135 ! distal tubule intersection_of: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0005309 ! pronephric nephron [Term] id: UBERON:0006182 name: mesonephric glomerular mesangium def: "The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus" [] is_a: UBERON:0002320 ! glomerular mesangium intersection_of: UBERON:0002320 ! glomerular mesangium intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005326 ! mesonephric glomerulus vasculature [Term] id: UBERON:0006183 name: mesonephric glomerular capillary def: "." [] is_a: UBERON:0004212 ! glomerular capillary intersection_of: UBERON:0004212 ! glomerular capillary intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron relationship: part_of UBERON:0005325 ! mesonephric glomerulus [Term] id: UBERON:0006189 name: mesonephric connecting tubule def: "The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros" [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0005097 ! renal connecting tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0005097 ! renal connecting tubule intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0006190 name: mesonephric distal tubule def: "The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule" [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004135 ! distal tubule intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0006192 name: mesonephric proximal tubule def: "The mesonephric proximal tubule extends from the capsule to the distal tubule" [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004134 ! proximal tubule intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0005322 ! mesonephric nephron [Term] id: UBERON:0006211 name: buccopharyngeal membrane def: "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." [] synonym: "oral membrane" RELATED [] synonym: "oral plate" RELATED [] synonym: "oropharyngeal membrane" RELATED [] synonym: "pharyngeal membrane" RELATED [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003037 ! septum relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0006264 ! mouth-foregut junction [Term] id: UBERON:0006215 name: rhombic lip def: "The posterior section of the developing metencephalon within an embryo, extending posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system." [] synonym: "cerebellar anlage" RELATED [] synonym: "cerebellum primordium" RELATED [] synonym: "dorsal part of alar plate of metencephalon" RELATED [] synonym: "future cerebellum" RELATED [] synonym: "presumptive cerebellum" RELATED [] synonym: "rostral rhombic lip" RELATED [] is_a: UBERON:0001048 ! primordium relationship: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0010092 ! future metencephalon [Term] id: UBERON:0006232 name: facio-acoustic VII-VIII preganglion complex is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0005565 ! facio-acoustic neural crest relationship: part_of UBERON:0001714 ! cranial ganglion [Term] id: UBERON:0006235 name: foregut-midgut junction def: "An anatomical junctions that overlaps the foregut and midgut." [] is_a: UBERON:0007651 ! anatomical junction relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0006238 name: future brain def: "The embryonic precursor of the brain." [] synonym: "brain rudiment" EXACT [] synonym: "encephalon" NARROW [] synonym: "presumptive brain" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0001049 ! neural tube relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0006240 name: future forebrain synonym: "future prosencephalon" EXACT [] synonym: "presumptive forebrain" EXACT [] synonym: "presumptive prosencephalon" EXACT [] synonym: "prosencephalon" RELATED [] is_a: UBERON:0006598 ! presumptive structure relationship: part_of UBERON:0006238 ! future brain [Term] id: UBERON:0006242 name: gall bladder primordium is_a: UBERON:0001048 ! primordium relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0002423 ! hepatobiliary system relationship: part_of UBERON:0004912 ! biliary bud [Term] id: UBERON:0006264 name: mouth-foregut junction def: "An anatomical junctions that overlaps the mouth and foregut." [] is_a: UBERON:0007651 ! anatomical junction relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0006266 name: nasolacrimal groove def: "Groove between maxillary prominence and lateral nasal process." [] synonym: "naso-lacrimal groove" EXACT [] synonym: "s. lacrimalis maxillae" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0012313 ! 1st arch maxillary ectoderm relationship: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0006267 name: notochordal plate def: "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0006268 ! notochordal process relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0006268 name: notochordal process def: "a midline cellular cord formed from the migration of mesenchymal cells from the primitive knot" [] synonym: "chordamesoderm" RELATED [] synonym: "presumptive notochord" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0000924 ! ectoderm [Term] id: UBERON:0006273 name: otic pit def: "The auditory pit, also known as the otic pit, is the first rudiment of the internal ear. It appears shortly after that of the eye, in the form of a patch of thickened ectoderm, the auditory plate, over the region of the hind-brain. The auditory plate becomes depressed and converted into the auditory pit (or otic pit)." [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0006283 name: primitive ventricle of heart def: "The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum." [] synonym: "early heart ventricle" EXACT [] synonym: "embryonic heart ventricle" EXACT [] synonym: "embryonic ventricle" BROAD [] synonym: "future heart ventricle" EXACT [] synonym: "primitive ventricle" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0005498 ! primitive heart tube [Term] id: UBERON:0006284 name: early prosencephalic vesicle def: "future brain vesicle that gives rise to telencephalic ventricle/lateral ventricles and 3rd ventricle" [] synonym: "forebrain ventricle" RELATED [] synonym: "forebrain vesicle" RELATED [] synonym: "preevaginated forebrain vesicle" NARROW [] synonym: "prosencephalic ventricle" RELATED [] synonym: "prosencephalic vesicle" EXACT [] is_a: UBERON:0013150 ! future brain vesicle [Term] id: UBERON:0006293 name: spleen primordium def: "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." [] synonym: "left spleen primordium" NARROW [] synonym: "spleen mesenchyme" EXACT [] synonym: "splenic mesenchyme" EXACT [] synonym: "splenic primordium" EXACT [] is_a: UBERON:0001048 ! primordium is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: part_of UBERON:0005602 ! dorsal mesogastrium [Term] id: UBERON:0006311 name: chamber of eyeball def: "Chamber of eyeball[FMA]" [] synonym: "chamber of eye" RELATED [] synonym: "eye chamber" EXACT [] synonym: "eyeball chamber" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0006331 name: brainstem nucleus def: "A nucleus of brain that is part of a brainstem." [] is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0002298 ! brainstem relationship: part_of UBERON:0002298 ! brainstem [Term] id: UBERON:0006338 name: lateral ventricle choroid plexus stroma def: "A choroid plexus stroma that is part of a lateral ventricle." [] is_a: UBERON:0005206 ! choroid plexus stroma is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0005206 ! choroid plexus stroma intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002307 ! choroid plexus of lateral ventricle [Term] id: UBERON:0006340 name: fourth ventricle choroid plexus stroma def: "A choroid plexus stroma that is part of a fourth ventricle." [] is_a: UBERON:0005206 ! choroid plexus stroma is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0005206 ! choroid plexus stroma intersection_of: part_of UBERON:0002422 ! fourth ventricle relationship: part_of UBERON:0002290 ! choroid plexus of fourth ventricle relationship: part_of UBERON:0002422 ! fourth ventricle [Term] id: UBERON:0006341 name: outer renal medulla peritubular capillary def: "A peritubular capillary that is part of a outer medulla of kidney." [] synonym: "kidney outer medulla peritubular capillary" EXACT [] is_a: UBERON:0005272 ! peritubular capillary intersection_of: UBERON:0005272 ! peritubular capillary intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: UBERON:0006376 name: premacula segment of distal straight tubule def: "." [] synonym: "distal straight tubule premacula segment" EXACT [] synonym: "kidney medulla loop of Henle ascending limb thick segment" EXACT [] synonym: "medullary thick ascending limb of Henle's loop" EXACT [] synonym: "renal medulla loop of Henle ascending limb thick segment" EXACT [] synonym: "renal medulla thick ascending limb" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0008408 ! distal tubular epithelium relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle relationship: part_of UBERON:0006541 ! outer medulla inner stripe loop of henle relationship: part_of UBERON:0006542 ! outer medulla outer stripe loop of henle [Term] id: UBERON:0006435 name: os penis def: "a bone found in the penis of most mammals. It is absent in humans, but present in other primates, such as the closely-related chimpanzee. The bone aids in sexual intercourse[WP]." [] synonym: "baculum" EXACT [] synonym: "os baculum" EXACT [] synonym: "penile bone" EXACT [] synonym: "penis bone" EXACT [] is_a: UBERON:0007719 ! bone of reproductive structure is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000989 ! penis relationship: part_of UBERON:0000989 ! penis [Term] id: UBERON:0006444 name: annulus fibrosus def: "A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart)." [] synonym: "anulus fibrosus" EXACT [] synonym: "fibrous ring" RELATED [] is_a: UBERON:0001995 ! fibrocartilage [Term] id: UBERON:0006524 name: alveolar system def: "System pertaining to a bronchus and alveoli." [] synonym: "bronchoalveolar system" RELATED [] synonym: "pulmonary alveolar system" EXACT [] is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0006534 name: renal convoluted tubule synonym: "convoluted tubule" EXACT [] synonym: "kidney convoluted tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0006541 name: outer medulla inner stripe loop of henle def: "A loop of Henle that is part of a kidney outer medulla inner stripe." [] is_a: UBERON:0001288 ! loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: part_of UBERON:0004201 ! kidney outer medulla inner stripe relationship: part_of UBERON:0004201 ! kidney outer medulla inner stripe [Term] id: UBERON:0006542 name: outer medulla outer stripe loop of henle def: "A loop of Henle that is part of a kidney outer medulla outer stripe." [] is_a: UBERON:0001288 ! loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: part_of UBERON:0004202 ! kidney outer medulla outer stripe relationship: part_of UBERON:0004202 ! kidney outer medulla outer stripe [Term] id: UBERON:0006544 name: kidney vasculature def: "A vasculature that is part of a kidney." [] is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0006553 name: renal duct def: "A tube in the kidney that collect and transport urine." [] is_a: UBERON:0000058 ! duct is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0006554 name: urinary system structure def: "An anatomical structure that is part of a excretory system." [] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0006555 name: excretory tube def: "A tube that is part of a excretory system." [] is_a: UBERON:0000025 ! tube is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000025 ! tube intersection_of: part_of UBERON:0001008 ! renal system relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0006558 name: lymphatic part of lymphoid system def: "." [] synonym: "lymphatic system" EXACT [] synonym: "lymphatic tree system" EXACT [] synonym: "lymporeticular system" RELATED [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001009 ! circulatory system relationship: part_of UBERON:0002465 ! lymphoid system relationship: part_of UBERON:0007798 ! vascular system [Term] id: UBERON:0006561 name: non-lymphatic part of lymphoid system synonym: "non-lymphatic lymphoid system" EXACT [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0002465 ! lymphoid system [Term] id: UBERON:0006562 name: pharynx def: "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." [] synonym: "pharyngeal tube" EXACT [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0006566 name: left ventricle myocardium def: "Myocardium of ventricle which is continuous with the tunica media of aorta.[FMA]" [] synonym: "Left ventricular myocardium" EXACT [] synonym: "myocardium of left ventricle" EXACT [] is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0006567 name: right ventricle myocardium def: "Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk.[FMA]" [] synonym: "myocardium of right ventricle" EXACT [] synonym: "Right ventricular myocardium" EXACT [] is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0006568 name: hypothalamic nucleus def: "A nucleus of brain that is part of a hypothalamus." [] synonym: "nucleus of hypothalamus" EXACT [] is_a: UBERON:0003048 ! regional part of hypothalamus is_a: UBERON:0006569 ! diencephalic nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0001898 ! hypothalamus relationship: part_of UBERON:0001898 ! hypothalamus [Term] id: UBERON:0006569 name: diencephalic nucleus def: "A nucleus of brain that is part of a diencephalon." [] is_a: UBERON:0002308 ! nucleus of brain is_a: UBERON:0002784 ! regional part of diencephalon intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0006585 name: vestibular organ def: "An organ that is part of a vestibular system." [] synonym: "balance organ" EXACT [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0004681 ! vestibular system relationship: part_of UBERON:0000012 ! somatic nervous system relationship: part_of UBERON:0004681 ! vestibular system [Term] id: UBERON:0006595 name: presumptive endoderm is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0006598 name: presumptive structure synonym: "presumptive structures" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0006601 name: presumptive ectoderm synonym: "presumptive epidermis" RELATED [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0006603 name: presumptive mesoderm is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0006615 name: venous sinus def: "a large vein or channel for the circulation of venous blood" [] is_a: UBERON:0003920 ! venous blood vessel [Term] id: UBERON:0006642 name: muscle layer of oviduct def: "A muscle layer that is part of a fallopian tube." [] synonym: "muscle layer of fallopian tube" EXACT [] synonym: "muscle layer of oviduct" EXACT [] synonym: "muscle layer of uterine tube" EXACT [] synonym: "muscular coat of uterine tube" EXACT [] synonym: "muscular layer of uterine tube" EXACT [] synonym: "muscularis of uterine tube" EXACT [] synonym: "tunica muscularis (Tuba uterina)" EXACT [] synonym: "tunica muscularis tubae uterinae" EXACT [] synonym: "uterine tubal muscularis" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscle layer is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0003889 ! fallopian tube relationship: part_of UBERON:0003889 ! fallopian tube [Term] id: UBERON:0006645 name: adventitia of epididymis def: "An adventitia that is part of a epididymis." [] synonym: "epididymis adventitia" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005742 ! adventitia is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0005742 ! adventitia intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] id: UBERON:0006646 name: muscle layer of epididymis def: "A muscle layer that is part of a epididymis." [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscle layer is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] id: UBERON:0006648 name: adventitia of seminal vesicle def: "An adventitia that is part of a seminal vesicle." [] synonym: "adventitia of seminal gland" EXACT [] synonym: "seminal vesicle adventitia" EXACT [] synonym: "tunica adventitia (vesicula seminalis)" EXACT [] synonym: "tunica adventitia glandulae vesiculosae" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005742 ! adventitia is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0005742 ! adventitia intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle [Term] id: UBERON:0006652 name: muscular layer of vagina def: "A muscle tissue that is part of a vagina." [] synonym: "muscular coat of vagina" EXACT [] synonym: "tunica muscularis vaginae" EXACT [] synonym: "vaginal muscularis" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscle layer is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0006660 name: muscle layer def: "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." [] synonym: "muscular coat" RELATED [] synonym: "muscular layer" EXACT [] synonym: "muscularis" RELATED [] synonym: "muscularis externa" RELATED [] synonym: "muscularis layer" EXACT [] synonym: "muscularis propria" RELATED [] synonym: "transverse muscular fibers" RELATED [] synonym: "tunica externa" RELATED [] synonym: "tunica muscularis" EXACT [] synonym: "tunica muscularis" RELATED [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0006686 name: spinal vein def: "A vein that is part of a vertebral column." [] synonym: "spinal branch" RELATED [] synonym: "Spinal vein" EXACT [] synonym: "vena spinalis" EXACT [] is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0001130 ! vertebral column relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0006694 name: cerebellum vasculature is_a: UBERON:0005284 ! brain vasculature is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: UBERON:0006725 name: spiral ligament def: "A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous cochlear duct to the bony spiral canal of the cochlea. Its spiral ligament fibrocytes function in conjunction with the stria vascularis to mediate cochlear ion homeostasis." [] synonym: "ligamentum spirale ductus cochlearis" EXACT [] synonym: "spiral cochlear ligament" EXACT [] synonym: "spiral ligament of cochlear duct" EXACT [] is_a: UBERON:0000211 ! ligament is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001855 ! cochlear duct of membranous labyrinth [Term] id: UBERON:0006763 name: epithelium of conjunctiva def: "Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue" [] synonym: "conjunctiva epithelium" EXACT [] synonym: "conjunctival epithelium" EXACT [] is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva [Term] id: UBERON:0006799 name: glandular epithelium def: "Epithelium composed of secretory cells." [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0006815 name: areolar connective tissue def: "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.[FMA]" [] synonym: "loose areolar connective tissue" EXACT [] synonym: "loose connective tissue" RELATED [] is_a: UBERON:0011825 ! loose connective tissue relationship: part_of UBERON:0000030 ! lamina propria [Term] id: UBERON:0006846 name: surface groove def: "A furrow or an incomplete tube." [] synonym: "groove" RELATED [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0000479 ! tissue [Term] id: UBERON:0006851 name: renal cortex peritubular capillary def: "A peritubular capillary that is part of a cortex of kidney." [] synonym: "kidney cortex peritubular capillary" EXACT [] is_a: UBERON:0005272 ! peritubular capillary intersection_of: UBERON:0005272 ! peritubular capillary intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0006853 name: renal cortex tubule def: "A region of nephron tubule that is part of a cortex of kidney." [] synonym: "cortical tubule" RELATED [] synonym: "kidney cortex tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule intersection_of: UBERON:0007685 ! region of nephron tubule intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0006854 name: distal straight tubule postmacula segment def: "." [] synonym: "cortical thick ascending limb of Henle's loop" EXACT [] synonym: "kidney cortex loop of Henle ascending limb thick segment" EXACT [] synonym: "renal cortex loop of Henle ascending limb thick segment" EXACT [] synonym: "renal cortex thick ascending limb" EXACT [] is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0008408 ! distal tubular epithelium relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle relationship: part_of UBERON:0006853 ! renal cortex tubule [Term] id: UBERON:0006855 name: ureter muscle layer def: "A muscle layer that is part of a ureter." [] synonym: "muscular coat of ureter" EXACT [] synonym: "muscular layer of ureter" EXACT [] synonym: "muscularis of ureter" EXACT [] synonym: "tunica muscularis (ureter)" EXACT [] synonym: "tunica muscularis ureteris" EXACT [] synonym: "ureteral smooth muscle layer" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0006660 ! muscle layer intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0009916 ! wall of ureter [Term] id: UBERON:0006858 name: adrenal/interrenal gland def: "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]" [] synonym: "adrenal - interrenal gland" RELATED [] synonym: "adrenal gland - interrenal gland" EXACT [] synonym: "adrenal gland/interrenal tissue" EXACT [] synonym: "suprarenal gland - interrenal gland" RELATED [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005172 ! abdomen organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0006866 name: terminal part of digestive tract synonym: "rectal part of digestive tract" RELATED [] synonym: "rectum" RELATED [] synonym: "terminal section of digestive tract" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract relationship: develops_from UBERON:0001046 ! hindgut [Term] id: UBERON:0006868 name: seminal fluid secreting gland def: "A gland that secretes a seminal fluid." [] is_a: UBERON:0005399 ! male reproductive gland relationship: part_of UBERON:0006947 ! male genital duct [Term] id: UBERON:0006876 name: vasculature of organ def: "A vasculature that is part of a organ." [] synonym: "organ vasculature" EXACT [] synonym: "set of blood vessels of organ" EXACT [] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000062 ! organ relationship: part_of UBERON:0000062 ! organ [Term] id: UBERON:0006877 name: vasculature of liver def: "A vasculature that is part of a liver." [] synonym: "hepatic vasculature" EXACT [] synonym: "liver vascular system" RELATED [] is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver [Term] id: UBERON:0006904 name: head mesenchyme from mesoderm def: "A head mesenchyme that develops_from a mesoderm." [] synonym: "cranial mesoderm" RELATED [] synonym: "head mesenchyme derived from mesoderm" EXACT [] synonym: "head mesenchyme from head mesoderm" EXACT [] synonym: "head mesenchyme from mesoderm" EXACT [] synonym: "head mesoderm" RELATED [] synonym: "mesenchyme derived from head mesoderm" EXACT [] synonym: "mesenchyme from head mesoderm" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0005253 ! head mesenchyme intersection_of: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0003063 ! prechordal plate [Term] id: UBERON:0006914 name: squamous epithelium def: "an epithelium characterised by its most superficial layer consisting of squamous epithelial cells." [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0006915 name: stratified squamous epithelium def: "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]" [] synonym: "epithelium stratificatum squamosum" EXACT [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium [Term] id: UBERON:0006916 name: non-keratinized epithelium of tongue is_a: UBERON:0006919 ! tongue squamous epithelium is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium intersection_of: UBERON:0010304 ! non-keratinized stratified squamous epithelium intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0006919 name: tongue squamous epithelium def: "A squamous epithelium that is part of a tongue." [] synonym: "squamous epithelium of tongue" EXACT [] is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0003357 ! epithelium of tongue is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0005020 ! mucosa of tongue [Term] id: UBERON:0006920 name: esophagus squamous epithelium def: "A squamous epithelium that is part of a esophagus." [] synonym: "esophageal squamous epithelium" RELATED [] synonym: "squamous epithelium of esophagus" RELATED [] synonym: "squamous oesophageal epithelium" RELATED [] is_a: UBERON:0001976 ! epithelium of esophagus is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus [Term] id: UBERON:0006921 name: stomach squamous epithelium def: "A squamous epithelium that is part of a stomach." [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: UBERON:0006922 name: cervix squamous epithelium def: "The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane." [] synonym: "cervical squamous epithelium" EXACT [] is_a: UBERON:0004801 ! cervix epithelium is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix [Term] id: UBERON:0006923 name: vagina squamous epithelium def: "A squamous epithelium that is part of a vagina." [] synonym: "vaginal squamous epithelium" EXACT [] is_a: UBERON:0001344 ! epithelium of vagina is_a: UBERON:0006915 ! stratified squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0006924 name: stomach glandular epithelium def: "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." [] synonym: "epithelium of gastric gland" NARROW [] synonym: "gastric gland epithelium" RELATED [] is_a: UBERON:0001276 ! epithelium of stomach is_a: UBERON:0006929 ! glandular columnar epithelium intersection_of: UBERON:0006799 ! glandular epithelium intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0006931 ! stomach glandular region mucosa [Term] id: UBERON:0006925 name: digestive gland def: "A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion." [] synonym: "digestive system gland" EXACT [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0013765 ! digestive system organ intersection_of: UBERON:0002368 ! endocrine gland intersection_of: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0006929 name: glandular columnar epithelium def: "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]" [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0006799 ! glandular epithelium [Term] id: UBERON:0006931 name: stomach glandular region mucosa def: "A mucosa of stomach that is part of a stomach glandular region." [] is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0001199 ! mucosa of stomach intersection_of: part_of UBERON:0011953 ! stomach glandular region relationship: part_of UBERON:0011953 ! stomach glandular region [Term] id: UBERON:0006932 name: vestibular epithelium def: "An epithelium that is part of a vestibular labyrinth." [] synonym: "epithelium of vestibular labyrinth" EXACT [] synonym: "inner ear vestibular component epithelium" EXACT [] synonym: "vestibular sensory epithelium" EXACT [] is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0006937 ! inner ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001862 ! vestibular labyrinth relationship: part_of UBERON:0001862 ! vestibular labyrinth [Term] id: UBERON:0006934 name: sensory epithelium def: "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." [] synonym: "neuroepithelium" RELATED [] is_a: UBERON:0000488 ! atypical epithelium relationship: part_of UBERON:0000010 ! peripheral nervous system [Term] id: UBERON:0006935 name: crista ampullaris neuroepithelium def: "An epithelium that is part of a crista ampullaris." [] synonym: "ampullary crest neuroepithelium" RELATED [] synonym: "epithelium of crista of ampulla of semicircular duct of membranous labyrinth" EXACT [] is_a: UBERON:0006932 ! vestibular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0004721 ! crista ampullaris relationship: part_of UBERON:0004721 ! crista ampullaris [Term] id: UBERON:0006937 name: inner ear epithelium def: "An epithelium that is part of a internal ear." [] is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0001846 ! internal ear [Term] id: UBERON:0006947 name: male genital duct def: "A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra." [] synonym: "sperm duct" EXACT [] synonym: "sperm ducts" EXACT [] is_a: UBERON:0005904 ! duct of male reproductive system relationship: part_of UBERON:0004054 ! internal male genitalia [Term] id: UBERON:0006955 name: uterine epithelium def: "An epithelium that is part of a uterus." [] synonym: "uterus epithelium" RELATED [] is_a: UBERON:0004804 ! oviduct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus [Term] id: UBERON:0006960 name: ovary stroma def: "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." [] synonym: "interstitial tissue of ovary" EXACT [] synonym: "ovarian stroma" EXACT [] synonym: "ovary stroma" EXACT [] synonym: "stroma of the ovary" EXACT [] synonym: "stroma ovarica" EXACT [] synonym: "stroma ovarii" RELATED [] is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0006964 name: pars distalis of adenohypophysis def: "The distal part of adenohypophysis: the part that makes up the main body of the gland." [] synonym: "anterior lobe" RELATED [] synonym: "DHP" BROAD [] synonym: "distal part of hypophysis" EXACT [] synonym: "distal part of the hypophysis" RELATED [] synonym: "pars anterior" BROAD [] synonym: "pars anterior of adenohypophysis" EXACT [] synonym: "pars distalis" RELATED [] synonym: "pars distalis (glandula pituitaria)" EXACT [] synonym: "pars distalis (hypophysis)" RELATED [] synonym: "pars distalis adenohypophyseos" RELATED [] synonym: "pars distalis adenohypophysis" EXACT [] synonym: "pars distalis lobi anterioris hypophyseos" RELATED [] synonym: "pars distalis of anterior lobe of pituitary gland" EXACT [] synonym: "pars glandularis" RELATED [] synonym: "pars glandularis of adenohypophysis" EXACT [] is_a: UBERON:0010371 ! ecto-epithelium relationship: part_of UBERON:0002196 ! adenohypophysis [Term] id: UBERON:0006965 name: vascular cord def: "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0014903 ! primordial vasculature [Term] id: UBERON:0006966 name: heart capillary def: "." [] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003498 ! heart blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0007005 name: cardiac mesoderm def: "the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." [] synonym: "cardiogenic mesoderm" RELATED [] synonym: "heart primordia" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: part_of UBERON:0004140 ! primary heart field relationship: part_of UBERON:0009881 ! anterior lateral plate mesoderm [Term] id: UBERON:0007010 name: cleaving embryo def: "Organism at the cleavage stage." [] is_a: UBERON:0000922 ! embryo [Term] id: UBERON:0007026 name: primitive gut synonym: "embryonic digestive tube" RELATED [] synonym: "future digestive tract" EXACT [] synonym: "future digestive tube" EXACT [] synonym: "future gut" EXACT [] synonym: "primordial digestive tube" RELATED [] synonym: "primordial gut" RELATED [] is_a: UBERON:0002050 ! embryonic structure [Term] id: UBERON:0007029 name: external covering of organism def: "The collection of structures that form the extenal covering of the organism." [] synonym: "body surface" EXACT [] synonym: "organism surface" EXACT [] synonym: "surface" RELATED [] is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0007037 name: mechanosensory system is_a: UBERON:0001032 ! sensory system [Term] id: UBERON:0007099 name: hyoid neural crest def: "Cranial neural crest that migrates into the hyoid arch." [] synonym: "hyoid crest" EXACT [] is_a: UBERON:0003099 ! cranial neural crest relationship: part_of UBERON:0003852 ! rhombencephalon neural crest [Term] id: UBERON:0007100 name: circulatory organ def: "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood[GO]." [] synonym: "adult heart" RELATED [] synonym: "cardiac pump" EXACT [] synonym: "cardiac structure" RELATED [] synonym: "dorsal tube" NARROW [] synonym: "heart" NARROW [] synonym: "heart or heart like organ" EXACT [] is_a: UBERON:0003103 ! compound organ relationship: part_of UBERON:0001009 ! circulatory system [Term] id: UBERON:0007123 name: pharyngeal pouch 2 def: "A pharyngeal puch that is between the pharyngeal arches 2 and 3." [] synonym: "2nd arch branchial pouch" EXACT [] synonym: "2nd arch branchial pouch endoderm" EXACT [] synonym: "2nd arch pouch endoderm" EXACT [] synonym: "2nd branchial pouch" EXACT [] synonym: "2nd pharyngeal pouch endoderm" EXACT [] synonym: "pharyngeal pouches 2" EXACT [] synonym: "second arch pharyngeal pouch" EXACT [] synonym: "second pharyngeal pouch" RELATED [] synonym: "second visceral pouch" EXACT [] synonym: "visceral pouch 2" EXACT [] is_a: UBERON:0004117 ! pharyngeal pouch [Term] id: UBERON:0007128 name: glomeral mesenchyme def: "Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm." [] synonym: "corpuscle" RELATED [] synonym: "glomerulus" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003064 ! intermediate mesoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0007134 name: trunk ganglion def: "Ganglion which is located in the trunk." [] synonym: "body ganglion" EXACT [] synonym: "trunk ganglia" EXACT [] is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0007135 name: neural keel def: "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." [] synonym: "presumptive central nervous system" RELATED [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0003075 ! neural plate [Term] id: UBERON:0007177 name: lamina propria of mucosa of colon def: "A lamina propria that is part of a colonic mucosa." [] synonym: "colonic lamina propria" EXACT [] synonym: "lamina propria mucosae of colon" EXACT [] synonym: "lamina propria of colonic mucosa" EXACT [] synonym: "lamina propria of colonic mucous membrane" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0000317 ! colonic mucosa relationship: part_of UBERON:0000317 ! colonic mucosa [Term] id: UBERON:0007188 name: mesothelium of serous pericardium def: "A mesothelium that is part of a serous pericardium." [] synonym: "mesothelium of pericardium" EXACT [] synonym: "pericardial mesothelium" EXACT [] synonym: "serous pericardium mesothelium" EXACT [] is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: part_of UBERON:0002357 ! serous pericardium relationship: part_of UBERON:0002357 ! serous pericardium [Term] id: UBERON:0007196 name: tracheobronchial tree def: "the structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." [] synonym: "tracheobronchial system" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0007204 name: brachiocephalic vasculature def: "The vasculature consisting of brachiocephalic arteries and veins." [] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0007213 name: mesenchyme derived from head neural crest def: "Mesenchyme that develops_from a cranial neural crest." [] synonym: "head mesenchyme from cranial neural crest" EXACT [] synonym: "head mesenchyme from neural crest" EXACT [] synonym: "head neural crest derived mesenchyme" EXACT [] is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0003099 ! cranial neural crest relationship: develops_from UBERON:0003099 ! cranial neural crest [Term] id: UBERON:0007214 name: mesenchyme derived from trunk neural crest def: "Mesenchyme that develops_from a trunk neural crest." [] synonym: "trunk mesenchyme from neural crest" EXACT [] synonym: "trunk neural crest derived mesenchyme" EXACT [] is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0003083 ! trunk neural crest relationship: develops_from UBERON:0003083 ! trunk neural crest [Term] id: UBERON:0007238 name: 1st arch maxillary component is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0007240 name: tunica adventitia of artery def: "A tunica adventitia that is part of a artery." [] synonym: "arterial adventitia" EXACT [] synonym: "tunica externa (adventitia)(arteriae)" EXACT [] is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0000415 ! artery wall relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0007241 name: tunica adventitia of vein def: "A tunica adventitia that is part of a vein." [] synonym: "tunica externa (adventitia)(venae)" EXACT [] synonym: "venous adventitia" EXACT [] is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein [Term] id: UBERON:0007242 name: tunica intima of vein def: "A tunica intima that is part of a vein." [] synonym: "tunica interna (intima)(venae)" EXACT [] synonym: "venous intima" EXACT [] is_a: UBERON:0002523 ! tunica intima intersection_of: UBERON:0002523 ! tunica intima intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein [Term] id: UBERON:0007245 name: nuclear complex of neuraxis def: "Internal gray matter component which consists of an assemblage of nuclei of neuraxis. Example: cerebellar nuclear complex, Vestibular nuclear complex.[FMA]" [] synonym: "cluster of neural nuclei" RELATED [] synonym: "neural nuclei" RELATED [] synonym: "nuclear complex" RELATED [] is_a: UBERON:0002020 ! gray matter of neuraxis [Term] id: UBERON:0007267 name: trachea pre-cartilage rings def: "A pre-cartilage condensation that is part of a trachea." [] is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0009505 ! associated mesenchyme of trachea intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0009505 ! associated mesenchyme of trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0007277 name: presumptive hindbrain def: "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." [] synonym: "embryonic rhombencephalon" RELATED [] synonym: "future hindbrain" RELATED [] synonym: "rhombencephalon" RELATED [] is_a: UBERON:0006598 ! presumptive structure relationship: develops_from UBERON:0003076 ! posterior neural tube relationship: part_of UBERON:0006238 ! future brain [Term] id: UBERON:0007280 name: presumptive endocardium def: "A presumptive structure that has_potential_to_develop_into a endocardium." [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0007282 name: presumptive segmental plate def: "A presumptive structure that has_potential_to_develop_into a presomitic mesoderm." [] is_a: UBERON:0006598 ! presumptive structure relationship: develops_from UBERON:0009618 ! trunk paraxial mesoderm [Term] id: UBERON:0007284 name: presumptive neural plate def: "A presumptive structure that has_potential_to_develop_into a neural plate." [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0007285 name: presumptive paraxial mesoderm def: "A presumptive structure that has_potential_to_develop_into a paraxial mesoderm." [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0007297 name: presumptive pronephric mesoderm def: "A presumptive structure that has_potential_to_develop_into a pronephric mesoderm." [] synonym: "nephron primordium" EXACT [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0007298 name: pronephric proximal convoluted tubule def: "A proximal convoluted tubule that is part of a pronephros." [] is_a: UBERON:0001287 ! proximal convoluted tubule is_a: UBERON:0006173 ! pronephric proximal tubule intersection_of: UBERON:0001287 ! proximal convoluted tubule intersection_of: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0005309 ! pronephric nephron [Term] id: UBERON:0007303 name: pharyngeal vasculature def: "A vasculature that is part of a chordate pharynx." [] synonym: "branchial vasculature" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0007306 name: pronephric glomerular capillary def: "A glomerular capillary that is part of a pronephros." [] is_a: UBERON:0004212 ! glomerular capillary intersection_of: UBERON:0004212 ! glomerular capillary intersection_of: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0004739 ! pronephric glomerulus relationship: part_of UBERON:0005309 ! pronephric nephron [Term] id: UBERON:0007324 name: pancreatic lobe synonym: "lobulus pancreaticus" EXACT [] synonym: "pancreas lobe" EXACT [] synonym: "pancreatic lobule" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: UBERON:0007329 name: pancreatic duct def: "A duct that is part of the pancreas and connected to the duodenum." [] synonym: "duct of pancreas" EXACT [] synonym: "ductus pancreaticus" RELATED [] synonym: "pancreas duct" EXACT [] is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0003922 ! pancreatic bud relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: UBERON:0007352 name: stria vascularis vasculature def: "blood vessels supplying the stria vascularis in the cochlea of the inner ear." [] is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct [Term] id: UBERON:0007376 name: outer epithelial layer def: "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. The epidermis of a more complex invertebrate is just one-layer deep, and may be protected by a non-cellular cuticle. The epidermis of a higher vertebrate has many layers, and the outer layers are reinforced with keratin and then die[WP]." [] synonym: "epidermis" NARROW [] synonym: "hypodermis" RELATED [] synonym: "outer epidermal layer" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0003102 ! surface structure [Term] id: UBERON:0007383 name: enveloping layer of ectoderm def: "Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm." [] synonym: "enveloping layer" EXACT [] synonym: "EVL" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0007414 name: nucleus of midbrain tegmentum def: "A nucleus of brain that is part of a midbrain tegmentum." [] synonym: "tegmental nucleus" EXACT [] is_a: UBERON:0002635 ! regional part of midbrain tegmentum is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009661 ! midbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: part_of UBERON:0001943 ! midbrain tegmentum relationship: part_of UBERON:0001943 ! midbrain tegmentum [Term] id: UBERON:0007415 name: nucleus of midbrain reticular formation def: "A nucleus of midbrain tegmentum that is part of a midbrain reticular formation." [] synonym: "Mesencephalic reticular nucleus" RELATED [] synonym: "mesencephalic reticular nucleus" RELATED [] synonym: "midbrain reticular formation nucleus" EXACT [] synonym: "midbrain reticular nucleus" EXACT [] is_a: UBERON:0007414 ! nucleus of midbrain tegmentum intersection_of: UBERON:0007414 ! nucleus of midbrain tegmentum intersection_of: part_of UBERON:0002639 ! midbrain reticular formation relationship: part_of UBERON:0002639 ! midbrain reticular formation [Term] id: UBERON:0007473 name: lumen of epithelial sac def: "The space within an epithelial sphere." [] synonym: "cavity of vesicle" EXACT [] is_a: UBERON:0012467 ! enclosed anatomical space [Term] id: UBERON:0007475 name: matrix-based tissue def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0007497 name: developing epithelial placode def: "A domain of columnar epithelium in an embryo that represents the early stage of the development of the epithelial component of a new anatomical structure." [] synonym: "epithelial placode" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0001048 ! primordium [Term] id: UBERON:0007499 name: epithelial sac def: "An epithelial tube that is open at one end only." [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0009856 ! sac [Term] id: UBERON:0007501 name: arborizing epithelial duct system def: "A collection of connected epithelial tubes with a single portal." [] synonym: "arborising epithelial duct system" EXACT [] is_a: UBERON:0007499 ! epithelial sac [Term] id: UBERON:0007503 name: epithelial vesicle def: "A closed epithelium with a lumen." [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0007521 name: smooth muscle sphincter def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004590 ! sphincter muscle [Term] id: UBERON:0007524 name: dense mesenchyme tissue def: "Mesenchyme with little extracellular matrix." [] is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0007530 name: migrating mesenchyme population def: "Mesenchymal cells that are migrating." [] is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0007589 name: ciliated columnar oviduct epithelium def: "A ciliated columnar epithelium that is part of a oviduct." [] synonym: "uterine tube epithelium" EXACT [] is_a: UBERON:0004804 ! oviduct epithelium is_a: UBERON:0007592 ! ciliated columnar epithelium intersection_of: UBERON:0007592 ! ciliated columnar epithelium intersection_of: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0000993 ! oviduct [Term] id: UBERON:0007592 name: ciliated columnar epithelium def: "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]" [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0007601 ! ciliated epithelium [Term] id: UBERON:0007601 name: ciliated epithelium def: "Epithelium bearing vibratile cilia on the free surface." [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0007616 name: layer of synovial tissue def: "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." [] synonym: "stratum synoviale" NARROW [] synonym: "synovial layer" NARROW [] synonym: "synovial membrane" NARROW [] synonym: "synovial tissue" RELATED [] synonym: "synovium" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0007617 name: synovial cavity of joint def: "An anatomical cavity that surrounded_by a synovial joint." [] synonym: "articular cavity (synovial joint)" EXACT [] synonym: "cavitas articularis (junctura synovialis)" EXACT [] synonym: "cavity of synovial joint" EXACT [] is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: part_of UBERON:0002217 ! synovial joint relationship: part_of UBERON:0002217 ! synovial joint [Term] id: UBERON:0007625 name: pigment epithelium of eye def: "epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." [] synonym: "eye pigment epithelium" RELATED [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye [Term] id: UBERON:0007635 name: nucleus of medulla oblongata def: "A neural nucleus that is part of a medulla oblongata." [] is_a: UBERON:0002678 ! regional part of medulla oblongata is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: part_of UBERON:0001896 ! medulla oblongata relationship: part_of UBERON:0001896 ! medulla oblongata [Term] id: UBERON:0007644 name: thoracic lymph node def: "A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes" [] synonym: "lymph node of thorax" EXACT [] is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0007645 name: future meninx def: "A developing anatomical structure that is the outermost mesenchymal covering of the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx." [] synonym: "meninx primitiva" RELATED [] synonym: "primary meninx" EXACT [] synonym: "primitive meninx" RELATED [] synonym: "primordial meninx" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0010743 ! meningeal cluster [Term] id: UBERON:0007647 name: ectomeninx def: "the layer of mesoderm from which the dura mater and much of the membrane bone of the skull develop in the higher vertebrate embryo." [] is_a: UBERON:0007645 ! future meninx relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0007651 name: anatomical junction def: "Anatomical structure in which parts of two or more anatomical structures establish physical continuity with one another or intermingle their component parts. Examples: gastroesophageal junction, line alba, knee joint.[FMA]" [] synonym: "anatomical junction" EXACT [] synonym: "junction" BROAD [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0007652 name: esophageal sphincter def: "A sphincter muscle that is part of an esophagus." [] synonym: "oesophagial sphincter" EXACT [] is_a: UBERON:0003832 ! esophagus muscle is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus [Term] id: UBERON:0007684 name: uriniferous tubule def: "functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule." [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006555 ! excretory tube relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0007685 name: region of nephron tubule synonym: "region of renal tubule" RELATED [] synonym: "renal tubule region" EXACT [] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0004810 ! nephron tubule epithelium relationship: part_of UBERON:0001231 ! nephron tubule [Term] id: UBERON:0007687 name: kidney field def: "region of the embryo into the area in which the kidney rudiment will develop." [] synonym: "kidney anlage" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0007689 name: thyroid diverticulum def: "endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP]." [] synonym: "saccus thyroideus; diverticulum thyroideum" RELATED [] is_a: UBERON:0001048 ! primordium relationship: develops_from UBERON:0003091 ! thyroid primordium [Term] id: UBERON:0007690 name: early pharyngeal endoderm def: "." [] synonym: "early pharyngeal arch endoderm" EXACT [] synonym: "pharyngeal arch endoderm" RELATED [] synonym: "pharyngeal endoderm" RELATED [] synonym: "pharyngeal region endoderm" RELATED [] is_a: UBERON:0000925 ! endoderm is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0000925 ! endoderm relationship: part_of UBERON:0008814 ! pharyngeal system relationship: part_of UBERON:0009722 ! entire pharyngeal arch endoderm [Term] id: UBERON:0007719 name: bone of reproductive structure def: "A bone that is part of a reproductive structure." [] synonym: "baculum" NARROW [] synonym: "os penis/os clitoris" RELATED [] is_a: UBERON:0001474 ! bone element is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0005156 ! reproductive structure relationship: part_of UBERON:0005156 ! reproductive structure [Term] id: UBERON:0007771 name: epidermis gland def: "A gland that is part of a epidermis." [] synonym: "epidermal gland" EXACT [] synonym: "gland of epidermis" EXACT [] is_a: UBERON:0002419 ! skin gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis [Term] id: UBERON:0007777 name: umbilical vein endothelium def: "An endothelium that is part of a umbilical vein." [] is_a: UBERON:0001919 ! endothelium of vein intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein [Term] id: UBERON:0007778 name: umbilical artery endothelium def: "An endothelium that is part of a umbilical artery." [] is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001310 ! umbilical artery relationship: part_of UBERON:0001310 ! umbilical artery [Term] id: UBERON:0007798 name: vascular system synonym: "Gefaesssystem@ge" RELATED [] is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0007806 name: connecting stalk def: "A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord." [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm [Term] id: UBERON:0007808 name: adipose tissue of abdominal region def: "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." [] synonym: "abdominal adipose tissue" RELATED [] synonym: "abdominal fat" RELATED [] synonym: "intra-abdominal fat" RELATED [] is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003567 ! abdomen connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0007811 name: craniocervical region def: "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." [] synonym: "cephalic area" RELATED [] synonym: "cephalic part of animal" RELATED [] synonym: "cephalic region" RELATED [] synonym: "head and neck" RELATED [] synonym: "head or neck" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0000153 ! anterior region of body relationship: part_of UBERON:0013702 ! body proper [Term] id: UBERON:0007826 name: peritoneal mesentery def: "A double layer composed of peritoneum that attaches the visceral organs to the body wall." [] is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0002358 ! peritoneum relationship: part_of UBERON:0001178 ! visceral peritoneum relationship: part_of UBERON:0002358 ! peritoneum [Term] id: UBERON:0007842 name: membrane bone def: "Bone element that arises as a result of intramembranous ossification." [] is_a: UBERON:0001474 ! bone element [Term] id: UBERON:0007844 name: cartilage element def: "Skeletal element that is composed of cartilage tissue and may be permanent or transient." [] synonym: "cartilage" RELATED [] synonym: "cartilage organ" EXACT [] synonym: "cartilaginous element" EXACT [] synonym: "chondrogenic element" EXACT [] is_a: UBERON:0004765 ! skeletal element relationship: develops_from UBERON:0005863 ! cartilaginous condensation [Term] id: UBERON:0007845 name: regular connective tissue def: "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0007846 name: dense regular connective tissue def: "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." [] synonym: "dense fibrous connective tissue" EXACT [] synonym: "dense regular collagenous connective tissue" EXACT [] synonym: "dense regular collagenous tissue" EXACT [] synonym: "regular dense connective tissue" EXACT [] synonym: "typus regularis (textus connectivus collagenosus compactus)" EXACT [] is_a: UBERON:0007845 ! regular connective tissue is_a: UBERON:0011823 ! dense connective tissue [Term] id: UBERON:0007914 name: head or neck bone def: "A bone that is part of a craniocervical region." [] is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0007811 ! craniocervical region [Term] id: UBERON:0008001 name: irregular bone def: "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." [] synonym: "os irregulare" EXACT [] synonym: "os irregulare" RELATED [] is_a: UBERON:0001474 ! bone element [Term] id: UBERON:0008193 name: pneumatized bone def: "a bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. Skeletal pneumaticity is the presence of air spaces within bones. Skeletal pneumaticity exists only in synapsids and archosaurs. It is generally produced during development by excavation of bone by pneumatic diverticula (air sacs) from an air-filled space such as the lungs or nasal cavity. Pneumatization is highly variable between individuals, and bones not normally pneumatized can become pneumatized in pathological development. Pneumatization occurs in the skulls of mammals, crocodilians and birds among extant groups, as well as extinct archosaurs including the dinosaurs and pterosaurs. Pneumatic spaces include the paranasal sinuses and some of the mastoid cells[WP]." [] synonym: "hollow bone" RELATED [] synonym: "os pneumaticum" EXACT [] synonym: "pneumatic bone" EXACT [] is_a: UBERON:0008001 ! irregular bone [Term] id: UBERON:0008229 name: craniocervical region musculature def: "Musculature system of the pharyngeal and head regions." [] synonym: "head muscles" RELATED [] synonym: "head or neck muscle" EXACT [] synonym: "head or neck muscle" RELATED [] is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0007811 ! craniocervical region [Term] id: UBERON:0008266 name: periodontal ligament def: "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]." [] synonym: "alveolar periosteum" RELATED [] synonym: "alveolodental ligament" RELATED [] synonym: "alveolodental membrane" RELATED [] synonym: "desmodontium" RELATED [] synonym: "fibra periodontalis" EXACT [] synonym: "odontoperiosteum" RELATED [] synonym: "paradentium" RELATED [] synonym: "PDL" RELATED [] synonym: "peridental membrane" RELATED [] synonym: "peridontal fiber" RELATED [] synonym: "peridontal fibre" RELATED [] synonym: "peridontal ligament" RELATED [] synonym: "peridontal ligament fiber" RELATED [] synonym: "peridontal ligament fibre" RELATED [] synonym: "peridontal membrane" RELATED [] synonym: "peridontium" RELATED [] synonym: "periodontal fiber" EXACT [] synonym: "periodontal fibre" EXACT [] is_a: UBERON:0008846 ! skeletal ligament is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000211 ! ligament intersection_of: part_of UBERON:0001758 ! periodontium relationship: develops_from UBERON:0002342 ! neural crest relationship: develops_from UBERON:0008969 ! dental follicle relationship: part_of UBERON:0001758 ! periodontium [Term] id: UBERON:0008307 name: heart endothelium def: "An endothelium that is part of a heart [Automatically generated definition]." [] synonym: "cardiac endothelium" RELATED [] is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0008310 name: nasopharyngeal gland def: "A gland that is part of a nasopharynx." [] is_a: UBERON:0003295 ! pharyngeal gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx [Term] id: UBERON:0008342 name: intestinal villus of duodenum def: "An intestinal villus in the duodenum." [] is_a: UBERON:0001213 ! intestinal villus intersection_of: UBERON:0001213 ! intestinal villus intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0000320 ! duodenal mucosa relationship: part_of UBERON:0002114 ! duodenum [Term] id: UBERON:0008343 name: intestinal villus of jejunum def: "An intestinal villus in the jejunum." [] is_a: UBERON:0001213 ! intestinal villus intersection_of: UBERON:0001213 ! intestinal villus intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0000399 ! jejunal mucosa relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0008344 name: intestinal villus of ileum def: "An intestinal villus in the ileum." [] is_a: UBERON:0001213 ! intestinal villus intersection_of: UBERON:0001213 ! intestinal villus intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0000331 ! ileal mucosa relationship: part_of UBERON:0002116 ! ileum [Term] id: UBERON:0008345 name: ileal epithelium def: "An epithelium that is part of a ileum." [] synonym: "epithelium of ileum" EXACT [] is_a: UBERON:0013636 ! epithelium of intestinal villus intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0008344 ! intestinal villus of ileum [Term] id: UBERON:0008346 name: duodenal epithelium def: "An epithelium that is part of a duodenum." [] synonym: "epithelium of duodenum" EXACT [] is_a: UBERON:0013636 ! epithelium of intestinal villus intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008342 ! intestinal villus of duodenum [Term] id: UBERON:0008367 name: breast epithelium def: "An epithelium that is part of a breast." [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast [Term] id: UBERON:0008404 name: proximale tubular epithelium def: "The cells lining the proximal tubule are cuboidal epithelial cells with deep basal membrane invaginations that provide a large basal surface area. The long microvilli (the brush border) lining the tubule lumen, maximize luminal surface area and make these cells ideally suited for both reabsorptive and secretory functions." [] synonym: "proximale tubule epithelium" RELATED [] is_a: UBERON:0004810 ! nephron tubule epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0004134 ! proximal tubule relationship: part_of UBERON:0004134 ! proximal tubule [Term] id: UBERON:0008408 name: distal tubular epithelium def: "An epithelium that is part of a distal tubule." [] synonym: "distal tubule epithelium" RELATED [] is_a: UBERON:0004810 ! nephron tubule epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0004135 ! distal tubule relationship: part_of UBERON:0004135 ! distal tubule [Term] id: UBERON:0008425 name: mammary ridge def: "A bandlike thickening of ectoderm in the embryo extending from just below the axilla to the inguinal region and giving rise to the mammary glands[Stedmans]. One of two parallel lines, formed by thickenings of the epidermis (the mammary ridge) along the ventral surface of mammals of both sexes. They extend from the upper limbs (arms) to the lower limbs (legs) and are developed in the embryo. They give rise to the mammary glands and nipples but are otherwise usually not visible in the adult. The first manifestation of the mammary gland in many mammals is an elevated ridge or milk line, which then fragments into individual buds in specific regions lateral of the dorsal midline. These buds are either located in the thoracic region in primates, in the inguinal area in ungulates or along the entire length of the trunk in rodents and pigs. In humans, milk lines appear in the seventh week of embryonic development. After initial development of the milk lines they go into remission. Nipples develop on the milk lines of mammals. Most humans have two nipples, but in some cases more than two will develop. In most cases, these 'third nipples'and sometimes fourth nipplegrow along the milk line[WP]." [] synonym: "mammary fold" EXACT [] synonym: "milk line" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000924 ! ectoderm [Term] id: UBERON:0008522 name: nasal muscle def: "A muscle organ that is part of a olfactory apparatus." [] synonym: "muscle of nose" EXACT [] is_a: UBERON:0001577 ! facial nerve muscle is_a: UBERON:0003831 ! respiratory system muscle is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0000004 ! olfactory apparatus [Term] id: UBERON:0008715 name: muscle tissue of prostate def: "A muscle tissue that is part of a prostate gland." [] synonym: "prostate gland muscle tissue" EXACT [] synonym: "prostate muscle tissue" EXACT [] is_a: UBERON:0002385 ! muscle tissue is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0002385 ! muscle tissue intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0008780 name: inner cell mass derived epiblast def: "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers" [] synonym: "embryonic epiblast" RELATED [] is_a: UBERON:0002532 ! epiblast (generic) intersection_of: UBERON:0002532 ! epiblast (generic) intersection_of: develops_from UBERON:0000087 ! inner cell mass relationship: develops_from UBERON:0000087 ! inner cell mass relationship: part_of UBERON:0000091 ! bilaminar disc [Term] id: UBERON:0008811 name: intromittent organ def: "an external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP]." [] synonym: "aedeagus" NARROW [] synonym: "copulatory organ" RELATED [] synonym: "penis" NARROW [] is_a: UBERON:0003135 ! male reproductive organ relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0008814 name: pharyngeal system def: "A transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [] synonym: "pharyngeal apparatus" EXACT [] synonym: "pharyngeal arch region" EXACT [] synonym: "pharyngeal arches and clefts" RELATED [] is_a: UBERON:0002050 ! embryonic structure [Term] id: UBERON:0008816 name: embryonic head def: "A head that is part of a embryo." [] is_a: UBERON:0000033 ! head is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0000033 ! head intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0008817 name: thymus primordium endoderm def: "An endoderm that is part of a thymus primordium." [] is_a: UBERON:0000925 ! endoderm is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0005562 ! thymus primordium relationship: part_of UBERON:0005562 ! thymus primordium [Term] id: UBERON:0008823 name: neural tube derived brain def: "A brain that develops_from a neural tube." [] synonym: "vertebrate brain" NARROW [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0000955 ! brain intersection_of: UBERON:0000955 ! brain intersection_of: develops_from UBERON:0001049 ! neural tube relationship: develops_from UBERON:0001049 ! neural tube relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0008824 name: duct of epididymis def: "A duct that is part of a epididymis." [] synonym: "epididymal duct" EXACT [] synonym: "epididymis duct" EXACT [] is_a: UBERON:0005904 ! duct of male reproductive system intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] id: UBERON:0008835 name: hepatic diverticulum def: "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." [] synonym: "diverticulum hepaticum" RELATED [] synonym: "liver diverticulum" EXACT [] is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007499 ! epithelial sac is_a: UBERON:0009497 ! epithelium of foregut-midgut junction is_a: UBERON:0009854 ! digestive tract diverticulum relationship: develops_from UBERON:0003894 ! liver primordium relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0004161 ! septum transversum relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0008836 name: liver bud is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0008835 ! hepatic diverticulum [Term] id: UBERON:0008846 name: skeletal ligament def: "Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified]." [] synonym: "articular larua" EXACT [] synonym: "articular ligament" EXACT [] synonym: "ligament" BROAD [] synonym: "true ligament" EXACT [] is_a: UBERON:0000211 ! ligament relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0008856 name: stomach muscularis externa def: "the smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines" [] synonym: "gastric muscularis" EXACT [] synonym: "muscle layer of stomach" EXACT [] synonym: "muscularis externa of stomach" EXACT [] synonym: "tunica muscularis (gaster)" EXACT [] synonym: "tunica muscularis gastris" EXACT [] is_a: UBERON:0004222 ! stomach smooth muscle is_a: UBERON:0006660 ! muscle layer is_a: UBERON:0009034 ! stomach region intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0004222 ! stomach smooth muscle [Term] id: UBERON:0008859 name: cardiac gastric gland def: "A gastric gland in the cardiac region of the stomach; cardiac glands are fewer in number than in the fundus and body, and secrete mucin which coats the stomach and protects it[MP]" [] synonym: "cardiac gland" RELATED [] synonym: "gardiac gland" EXACT [] synonym: "gastric cardiac gland" EXACT [] synonym: "gastric gland of cardia" EXACT [] synonym: "glandula cardiaca (gaster)" EXACT [] is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland intersection_of: UBERON:0000325 ! gastric gland intersection_of: part_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0004996 ! mucosa of cardia of stomach [Term] id: UBERON:0008861 name: pyloric gastric gland def: "the gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." [] synonym: "glandula pylorica" EXACT [] synonym: "pyloric antrum gland" EXACT [] synonym: "pyloric gland" EXACT [] is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland intersection_of: UBERON:0000325 ! gastric gland intersection_of: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0004998 ! mucosa of pylorus [Term] id: UBERON:0008870 name: pulmonary alveolar parenchyma def: "the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [] is_a: UBERON:0008946 ! lung parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung [Term] id: UBERON:0008874 name: pulmonary acinus def: "the part of the airway consisting of a respiratory bronchiole and all of its branches" [] synonym: "primary pulmonary lobule" EXACT [] synonym: "respiratory lobule" EXACT [] is_a: UBERON:0010368 ! pulmonary lobule [Term] id: UBERON:0008876 name: hypodermis skeletal muscle layer def: "the skeletal muscle layer in the superficial fascia" [] synonym: "hypodermal muscle layer" EXACT [] synonym: "hypodermis muscle layer" EXACT [] synonym: "panniculus carnosus" RELATED [] is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis [Term] id: UBERON:0008883 name: osteoid def: "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue." [] synonym: "osteoid tissue" EXACT [] synonym: "pre-bone" EXACT [] synonym: "prebone" EXACT [] synonym: "prebone tissue" EXACT [] is_a: UBERON:0002481 ! bone tissue is_a: UBERON:0007475 ! matrix-based tissue [Term] id: UBERON:0008886 name: pulmonary vascular system def: "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." [] synonym: "pulmonary system" EXACT [] synonym: "pulmonary circulatory system" EXACT [] is_a: UBERON:0007798 ! vascular system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0008904 name: neuromast def: "Volcano-shaped lateral line sensory organ located in characteristic positions within the skin epithelium and containing hair cells and their support elements." [] synonym: "cyatocde@fr" EXACT [] synonym: "lateral line neuromast" EXACT [] synonym: "lateral line organ" EXACT [] synonym: "neuromaste superficiel@fr" EXACT [] synonym: "neuromasts" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0010202 ! lateral line [Term] id: UBERON:0008906 name: lateral line nerve def: "Cranial nerves that carry afferent and efferent fibers for the lateral line system." [] synonym: "lateral line nerves" EXACT [] is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002540 ! lateral line system relationship: develops_from UBERON:0009128 ! lateral line placode relationship: part_of UBERON:0002540 ! lateral line system [Term] id: UBERON:0008907 name: dermal bone def: "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." [] is_a: UBERON:0004756 ! dermal skeletal element is_a: UBERON:0007842 ! membrane bone intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0010364 ! dermal skeleton relationship: part_of UBERON:0010364 ! dermal skeleton [Term] id: UBERON:0008946 name: lung parenchyma def: "A parenchyma that is part of a lung." [] synonym: "parenchyma of lung" RELATED [] synonym: "respiratory portion of lung" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0008947 name: respiratory primordium is_a: UBERON:0001048 ! primordium relationship: part_of UBERON:0003258 ! endoderm of foregut [Term] id: UBERON:0008969 name: dental follicle def: "The dental follicle is a sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively." [] synonym: "tooth follicle" RELATED [] is_a: UBERON:0005087 ! tooth placode relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0000165 ! mouth [Term] id: UBERON:0008987 name: renal parenchyma def: "The functional tissue of the kidney, consisting of the nephrons." [] synonym: "kidney parenchyma" RELATED [] synonym: "parenchyma of kidney" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0008989 name: submocosal esophageal gland def: "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." [] synonym: "esophageal gland " EXACT [] synonym: "glandulae oesophageae" EXACT [] synonym: "mucous gland of submucosa of esophagus" EXACT [] is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0011148 ! submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0009034 name: stomach region def: "An organ part that is part of a stomach." [] is_a: UBERON:0000064 ! organ part intersection_of: UBERON:0000064 ! organ part intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: UBERON:0009089 name: inner medulla vasa recta descending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta [Term] id: UBERON:0009090 name: outer medulla vasa recta descending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta [Term] id: UBERON:0009091 name: vasa recta ascending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0004726 ! vasa recta [Term] id: UBERON:0009092 name: inner medulla vasa recta ascending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta [Term] id: UBERON:0009093 name: outer medulla vasa recta ascending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta [Term] id: UBERON:0009095 name: tip of renal papilla synonym: "papillary tip" EXACT [] synonym: "papillary tips" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001228 ! renal papilla [Term] id: UBERON:0009113 name: thymic region is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0000153 ! anterior region of body [Term] id: UBERON:0009114 name: cervical thymus def: "A mature thymus that is entirely part of the cervical region." [] is_a: UBERON:0002370 ! thymus intersection_of: UBERON:0002370 ! thymus intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0009115 name: thoracic thymus def: "A mature thymus that is entirely part of thoracic region." [] is_a: UBERON:0002370 ! thymus is_a: UBERON:0005178 ! thoracic cavity organ is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0002370 ! thymus intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0009117 name: indifferent gonad def: "A gonad prior to differentiating into a definitive testis or ovary." [] synonym: "gonad rudiment" RELATED [] is_a: UBERON:0000991 ! gonad relationship: part_of UBERON:0009196 ! indifferent external genitalia [Term] id: UBERON:0009122 name: adenohypophyseal placode def: "The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary" [] synonym: "pituitary placode" RELATED [] is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0011814 ! non-neurogenic ectodermal placode relationship: develops_from UBERON:0005497 ! non-neural ectoderm [Term] id: UBERON:0009123 name: otic cup is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003069 ! otic placode [Term] id: UBERON:0009128 name: lateral line placode synonym: "lateral line placodes" RELATED [] is_a: UBERON:0003067 ! dorsolateral placode [Term] id: UBERON:0009141 name: craniocervical region vein def: "A vein that is part of a craniocervical region." [] synonym: "craniocervical vein" EXACT [] synonym: "head and neck veins" EXACT [] synonym: "vein of head and neck" EXACT [] is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0004581 ! systemic venous system relationship: part_of UBERON:0007811 ! craniocervical region [Term] id: UBERON:0009142 name: entire embryonic mesenchyme def: "Sum total of mesenchyme in the embryo." [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0009143 name: developing esophageal region synonym: "esophageal region" BROAD [] synonym: "oesophageal region" BROAD [] synonym: "oesophageal region" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0009145 name: pharyngeal region is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0001041 ! foregut relationship: part_of UBERON:0001557 ! upper respiratory tract [Term] id: UBERON:0009196 name: indifferent external genitalia is_a: UBERON:0004176 ! external genitalia [Term] id: UBERON:0009198 name: craniofacial suture def: "any suture between cranial and/or facial bones." [] synonym: "articulation of skull bones" RELATED [] synonym: "joint of the skull bones" EXACT [] is_a: UBERON:0002209 ! fibrous joint [Term] id: UBERON:0009201 name: nephric duct def: "A nephric duct is a tube that drains a primitive kidney[GO]." [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006553 ! renal duct relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0009202 name: vasa recta descending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0004726 ! vasa recta [Term] id: UBERON:0009204 name: medial nasal process mesenchyme def: "Mesenchyme that is part of a medial nasal prominence." [] is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0004068 ! medial nasal prominence relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest relationship: part_of UBERON:0004068 ! medial nasal prominence [Term] id: UBERON:0009210 name: pharyngeal membrane def: "a thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo." [] synonym: "pharyngeal membrane" EXACT [] is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0008814 ! pharyngeal system [Term] id: UBERON:0009213 name: pharyngeal membrane of 1st arch def: "separates the first pharyngeal groove from the first pharyngeal pouch." [] synonym: "1st branchial membrane" EXACT [] synonym: "1st pharyngeal membrane" EXACT [] synonym: "future tympanic membrane" EXACT [] synonym: "tympanic membrane primordium" EXACT [] is_a: UBERON:0009210 ! pharyngeal membrane relationship: part_of UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0009292 name: embryonic nasal process synonym: "nasal placode" RELATED [] is_a: UBERON:0012314 ! embryonic facial prominence [Term] id: UBERON:0009477 name: associated mesenchyme of otic placode def: "Mesenchyme that is part of a otic placode." [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0003069 ! otic placode relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest relationship: part_of UBERON:0003069 ! otic placode [Term] id: UBERON:0009479 name: ectoderm of buccopharyngeal membrane def: "An ectoderm that is part of a buccopharyngeal membrane." [] is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0006211 ! buccopharyngeal membrane relationship: part_of UBERON:0006211 ! buccopharyngeal membrane [Term] id: UBERON:0009480 name: endoderm of buccopharyngeal membrane def: "An endoderm that is part of a buccopharyngeal membrane." [] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0006211 ! buccopharyngeal membrane relationship: part_of UBERON:0006211 ! buccopharyngeal membrane [Term] id: UBERON:0009482 name: associated mesenchyme of foregut-midgut junction def: "Mesenchyme that is part of a foregut-midgut junction." [] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0009483 name: mesentery of foregut-midgut junction def: "A mesentery that is part of a foregut-midgut junction." [] synonym: "foregut-midgut junction mesentery" EXACT [] is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0009494 name: pharyngeal arch mesenchymal region def: "A portion of mesenchymal tissue associated with an individual pharyngeal arch." [] synonym: "branchial arch mesenchyme" EXACT [] synonym: "pharyngeal arch mesenchyme" EXACT [] is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme [Term] id: UBERON:0009497 name: epithelium of foregut-midgut junction def: "An epithelium that is part of a foregut-midgut junction." [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: develops_from UBERON:0009550 ! endoderm of foregut-midgut junction relationship: part_of UBERON:0003929 ! gut epithelium relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0009500 name: associated mesenchyme of otocyst def: "Mesenchyme that is part of a ear vesicle." [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0003051 ! ear vesicle relationship: develops_from UBERON:0009477 ! associated mesenchyme of otic placode relationship: part_of UBERON:0003051 ! ear vesicle [Term] id: UBERON:0009501 name: mesenchyme of fronto-nasal process def: "the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head" [] synonym: "frontonasal mesenchyme" EXACT [] synonym: "naso-frontal mesenchyme" EXACT [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0004066 ! frontonasal prominence relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest relationship: part_of UBERON:0004066 ! frontonasal prominence [Term] id: UBERON:0009503 name: associated mesenchyme of hindgut def: "Mesenchyme that is part of a hindgut." [] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001046 ! hindgut relationship: part_of UBERON:0001046 ! hindgut [Term] id: UBERON:0009505 name: associated mesenchyme of trachea def: "Mesenchyme that is part of a trachea." [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0009506 name: associated mesenchyme of middle ear def: "Mesenchyme that is part of a middle ear." [] synonym: "middle ear associated mesenchyme" EXACT [] synonym: "otic mesenchyme" BROAD [] is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001756 ! middle ear relationship: part_of UBERON:0001756 ! middle ear [Term] id: UBERON:0009521 name: anal membrane endodermal component def: "An endoderm that is part of a anal region." [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001353 ! anal region relationship: develops_from UBERON:0000925 ! endoderm relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0009550 name: endoderm of foregut-midgut junction def: "An endoderm that is part of a foregut-midgut junction." [] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0009566 name: intestinal submucosa def: "A submucosa that is part of a intestine." [] synonym: "submucosa of intestine" EXACT [] is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0009569 name: subdivision of trunk synonym: "region of trunk" EXACT [] synonym: "trunk subdivision" EXACT [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0009581 name: midbrain mantle layer synonym: "mantle layer lateral wall mesencephalon" RELATED [] synonym: "mantle layer lateral wall midbrain" EXACT [] synonym: "midbrain lateral wall mantle layer" EXACT [] is_a: UBERON:0005883 ! neural tube lateral wall mantle layer relationship: part_of UBERON:0005495 ! midbrain lateral wall [Term] id: UBERON:0009610 name: forebrain neural plate def: "A neural plate that develops_from a future forebrain." [] is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: develops_from UBERON:0006240 ! future forebrain relationship: develops_from UBERON:0006240 ! future forebrain relationship: part_of UBERON:0003056 ! pre-chordal neural plate [Term] id: UBERON:0009611 name: midbrain neural plate def: "A neural plate that develops_from a presumptive midbrain." [] is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: develops_from UBERON:0009616 ! presumptive midbrain relationship: develops_from UBERON:0009616 ! presumptive midbrain relationship: part_of UBERON:0003056 ! pre-chordal neural plate [Term] id: UBERON:0009614 name: hindbrain neural plate def: "A neural plate that develops_from a presumptive hindbrain." [] is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: develops_from UBERON:0007277 ! presumptive hindbrain relationship: develops_from UBERON:0007277 ! presumptive hindbrain relationship: part_of UBERON:0003057 ! chordal neural plate [Term] id: UBERON:0009616 name: presumptive midbrain def: "A presumptive structure that has_potential_to_develop_into a midbrain." [] synonym: "early midbrain" RELATED [] synonym: "future midbrain" RELATED [] synonym: "mesencephalon" RELATED [] synonym: "presumptive mesencephalon" EXACT [] is_a: UBERON:0006598 ! presumptive structure relationship: develops_from UBERON:0003080 ! anterior neural tube relationship: develops_from UBERON:0010286 ! midbrain neural tube relationship: part_of UBERON:0006238 ! future brain [Term] id: UBERON:0009617 name: head paraxial mesoderm def: "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." [] synonym: "cephalic paraxial mesoderm" EXACT [] synonym: "head paraxial mesenchyme" EXACT [] is_a: UBERON:0006904 ! head mesenchyme from mesoderm relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0003077 ! paraxial mesoderm relationship: part_of UBERON:0005253 ! head mesenchyme [Term] id: UBERON:0009618 name: trunk paraxial mesoderm synonym: "trunk and cervical paraxial mesenchyme" EXACT [] synonym: "trunk paraxial mesenchyme" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005256 ! trunk mesenchyme relationship: develops_from UBERON:0000926 ! mesoderm relationship: part_of UBERON:0003077 ! paraxial mesoderm relationship: part_of UBERON:0005256 ! trunk mesenchyme [Term] id: UBERON:0009622 name: pronephric proximal straight tubule def: "A proximal straight tubule that is part of a pronephros." [] synonym: "proximal straight tubules" RELATED [] is_a: UBERON:0001290 ! proximal straight tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0001290 ! proximal straight tubule intersection_of: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0002120 ! pronephros relationship: part_of UBERON:0005309 ! pronephric nephron relationship: part_of UBERON:0006173 ! pronephric proximal tubule [Term] id: UBERON:0009623 name: spinal nerve root def: "The paired bundles of nerve fibers entering and leaving the spinal cord at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots efferent, comprising the axons of spinal motor and autonomic preganglionic neurons. There are, however, some exceptions to this afferent/efferent rule." [] synonym: "root of spinal nerve" EXACT [] synonym: "spinal neural root" EXACT [] synonym: "spinal root" EXACT [] is_a: UBERON:0002211 ! nerve root intersection_of: UBERON:0002211 ! nerve root intersection_of: part_of UBERON:0001780 ! spinal nerve relationship: part_of UBERON:0001780 ! spinal nerve [Term] id: UBERON:0009647 name: tympanic membrane epithelium def: "One of the two epithelia which make up the tympanic membrane (along with the fibrous layer)" [] synonym: "tympanic epithelium" EXACT [] synonym: "tympanic membrane epithelial layer" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0010071 ! layer of tympanic membrane intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002364 ! tympanic membrane relationship: part_of UBERON:0002364 ! tympanic membrane [Term] id: UBERON:0009648 name: eyelid subcutaneous connective tissue synonym: "superficial fascia of eyelid" RELATED [] is_a: UBERON:0003581 ! eyelid connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003581 ! eyelid connective tissue intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis [Term] id: UBERON:0009661 name: midbrain nucleus def: "Nucleus located in the midbrain." [] is_a: UBERON:0002308 ! nucleus of brain is_a: UBERON:0002950 ! regional part of midbrain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain [Term] id: UBERON:0009662 name: hindbrain nucleus def: "Nucleus located within the hindbrain." [] is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0009663 name: telencephalic nucleus def: "A nucleus of brain that is part of a telencephalon." [] is_a: UBERON:0002308 ! nucleus of brain is_a: UBERON:0002791 ! regional part of telencephalon intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0009664 name: gut mesentery is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0009676 name: early telencephalic vesicle synonym: "early telencephalic ventricle" RELATED [] synonym: "early telencephalic vesicle" EXACT [] is_a: UBERON:0013150 ! future brain vesicle relationship: develops_from UBERON:0006284 ! early prosencephalic vesicle [Term] id: UBERON:0009697 name: epithelium of appendix synonym: "appendix epithelium" EXACT [] synonym: "epithelium of vermiform appendix" EXACT [] is_a: UBERON:0005636 ! caecum epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: develops_from UBERON:0005636 ! caecum epithelium relationship: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0003929 ! gut epithelium relationship: part_of UBERON:0004989 ! mucosa of appendix [Term] id: UBERON:0009712 name: endocardium of right ventricle def: "Endocardium of ventricle which is continuous tricuspid valve, pulmonary valve and with the tunica intima of the pulmonary trunk." [] synonym: "endocardial lining of right ventricle" RELATED [] synonym: "right ventricle endocardial tissue" RELATED [] synonym: "right ventricle endocardium" EXACT [] synonym: "right ventricular endocardium" EXACT [] is_a: UBERON:0001081 ! endocardium of ventricle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: develops_from UBERON:0004706 ! bulbus cordis relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0009713 name: endocardium of left ventricle def: "Endocardium of ventricle which is continuous with mitral valve , aortic valve, atrioventricular septum and the tunica intima of the aorta." [] synonym: "endocardial lining of left ventricle" RELATED [] synonym: "left ventricle endocardial tissue" RELATED [] synonym: "left ventricle endocardium" EXACT [] synonym: "left ventricular endocardium" EXACT [] is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: develops_from UBERON:0006283 ! primitive ventricle of heart relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0009722 name: entire pharyngeal arch endoderm synonym: "pharyngeal arch endoderm" RELATED [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0003929 ! gut epithelium [Term] id: UBERON:0009751 name: cardiac mesenchyme def: "the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures" [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0009752 name: pancreas mesenchyme def: "the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas" [] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas [Term] id: UBERON:0009753 name: adrenal gland cortex zone synonym: "adrenal cortical region" EXACT [] synonym: "region of adrenal cortex" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: UBERON:0009758 name: abdominal ganglion def: "A ganglion that is part of a abdominal segment of trunk." [] is_a: UBERON:0007134 ! trunk ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0009773 name: renal tubule def: "A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [] synonym: "renal tubule (generic)" EXACT [] synonym: "tubule of excretory system" EXACT [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0006555 ! excretory tube relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0009778 name: pleural sac def: "Serous sac, which has as parts the pleura and the pleural cavity. Examples: There are only two canonical instances, right and left pleural sacs." [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005906 ! serous sac relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0009842 name: acinus def: "An acinus refers to any cluster of cells that resembles a many-lobed 'berry,' such as a raspberry (acinus is Latin for berry). The berry-shaped termination of an exocrine gland, where the secretion is produced is acinar in form, as is the alveolar sac containing multiple alveoli in the lungs." [] synonym: "acini" RELATED [] synonym: "glandular acinus" RELATED [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0009843 name: prostate epithelial cord def: "A solid cord of prostate epithelium." [] synonym: "cord of prostate epithelium" EXACT [] synonym: "epithelial cord of prostate" EXACT [] is_a: UBERON:0000428 ! prostate epithelium is_a: UBERON:0005154 ! epithelial cord intersection_of: UBERON:0005154 ! epithelial cord intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0009845 name: urogenital sinus mesenchyme def: "Mesenchyme that surrounds primitive urogenital sinus." [] synonym: "UGM" EXACT [] is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0009846 name: embryonic cloacal epithelium def: "An epithelium that is part of a embryonic cloaca." [] synonym: "cloacal epithelium" BROAD [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0012481 ! cloacal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000163 ! embryonic cloaca relationship: develops_from UBERON:0003353 ! epithelium of hindgut relationship: part_of UBERON:0000163 ! embryonic cloaca relationship: part_of UBERON:0003929 ! gut epithelium [Term] id: UBERON:0009847 name: prostate field def: "a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [] synonym: "prostate primordium" EXACT [] is_a: UBERON:0004902 ! urogenital sinus epithelium relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0004902 ! urogenital sinus epithelium [Term] id: UBERON:0009854 name: digestive tract diverticulum def: "Branch or outpocketing of the digestive tract." [] synonym: "diverticulum of gut" RELATED [] synonym: "intestinal pouch" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0009856 ! sac intersection_of: UBERON:0009856 ! sac intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0009856 name: sac synonym: "diverticulum" RELATED [] synonym: "pouch" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0009859 name: endosteum def: "a thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones" [] is_a: UBERON:0000158 ! membranous layer relationship: part_of UBERON:0002495 ! long bone [Term] id: UBERON:0009870 name: zone of stomach def: "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." [] synonym: "gastric zone" EXACT [] synonym: "region of stomach" EXACT [] synonym: "section of stomach" EXACT [] is_a: UBERON:0009034 ! stomach region relationship: part_of UBERON:0000945 ! stomach [Term] id: UBERON:0009871 name: nephrogenic zone def: "outer portion of the renal cortex. Site of formation of medullary and cortical elements." [] synonym: "nephrogenic tissue" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0009881 name: anterior lateral plate mesoderm synonym: "ALPM" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0009882 name: anal column def: "One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal. They are named after Giovanni Battista Morgagni who also has several other eponyms named after himself[WP]" [] synonym: "column of Morgagni" EXACT [] synonym: "columnae anales" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000159 ! anal canal [Term] id: UBERON:0009889 name: secondary heart field def: "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [] synonym: "anterior heart field" EXACT [] synonym: "anterior/second heart field" EXACT [] synonym: "second heart field" EXACT [] synonym: "SHF" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0009891 name: facial mesenchyme def: "Mesenchyme that is part of a face." [] synonym: "face mesenchyme" EXACT [] synonym: "mesenchyme of face" EXACT [] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001456 ! face relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0009911 name: lobule is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0009912 name: anatomical lobe is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0009913 name: renal lobe def: "the portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP]." [] synonym: "kidney lobe" EXACT [] synonym: "lobi renales" RELATED [] synonym: "lobi renalis" EXACT [] synonym: "lobus renalis" EXACT [] is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0009912 ! anatomical lobe intersection_of: UBERON:0009912 ! anatomical lobe intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0009914 name: renal lobule def: "the portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys" [] synonym: "cortical lobule" RELATED [] synonym: "cortical lobule of kidney" RELATED [] synonym: "kidney lobule" EXACT [] synonym: "lobuli corticales renis" RELATED [] synonym: "lobulus corticalis renalis" RELATED [] synonym: "lobulus renalis" EXACT [] synonym: "renal cortical lobule" RELATED [] synonym: "renculus" RELATED [] synonym: "reniculus" RELATED [] synonym: "renunculus" RELATED [] is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0009913 ! renal lobe [Term] id: UBERON:0009916 name: wall of ureter def: "An anatomical wall that is part of a ureter." [] synonym: "ureteral wall" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter [Term] id: UBERON:0009918 name: retrotrapezoid nucleus def: "the loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain" [] is_a: UBERON:0007635 ! nucleus of medulla oblongata relationship: part_of UBERON:0001896 ! medulla oblongata [Term] id: UBERON:0009919 name: ureter smooth muscle def: "the smooth muscle tissue surrounding the epithelium of the ureter" [] synonym: "ureteral smooth muscle" EXACT [] synonym: "ureteral smooth muscle layer" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0006855 ! ureter muscle layer [Term] id: UBERON:0009920 name: optic neural crest is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 ! migrating mesenchyme population relationship: part_of UBERON:0007213 ! mesenchyme derived from head neural crest [Term] id: UBERON:0009950 name: olfactory bulb plexiform layer synonym: "plexiform layer" BROAD [] is_a: UBERON:0004001 ! olfactory bulb layer [Term] id: UBERON:0009954 name: vomeronasal system def: "a vertebrate nasal chemosensory system that is responsible for detecting intraspecific pheromonal cues as well as environmental odorants" [] is_a: UBERON:0001032 ! sensory system relationship: part_of UBERON:0005725 ! olfactory system [Term] id: UBERON:0009955 name: neurogenic placode def: "Cranial placode with neurogenic potential[cjm]. Neurogenic placodes are transient ectodermal thickenings that form at the border of the neural plate and epidermis and give rise to sensory neurons of the cranial ganglia[ZFA]. The neurogenic placodes give rise to parts of various nerves and ganglia, the olfactory organ, parietal eye, parts of the inner ear, and the lateral line. There are 2 major series of neurogenic placodes, the dorsolateral and ventrolateral or epibranchial[PMID]" [] synonym: "neurogenic placodes" EXACT [] synonym: "placodae neurogenicae" RELATED [] is_a: UBERON:0002546 ! cranial placode [Term] id: UBERON:0009966 name: internodal tract def: "Subdivision of conducting system of heart which consists of the anterior, middle and posterior internodal tracts beneath the endocardium of interatrial septum and above the attachment of the septal leaflet of tricuspid valve." [] synonym: "interatrial conduction tract" EXACT [] synonym: "internodal conduction tract" EXACT [] synonym: "internodal fasciculus" EXACT [] synonym: "internodal tract muscle tissue" EXACT [] is_a: UBERON:0002385 ! muscle tissue relationship: part_of UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0009967 name: spleen venous sinus synonym: "sinus lienalis" EXACT [] synonym: "sinus splenicus" EXACT [] synonym: "splenic sinus" EXACT [] synonym: "venous sinus of red pulp of spleen" EXACT [] is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0006615 ! venous sinus relationship: part_of UBERON:0001250 ! red pulp of spleen [Term] id: UBERON:0009969 name: stato-acoustic epithelium is_a: UBERON:0006934 ! sensory epithelium [Term] id: UBERON:0009970 name: epithelium of pancreatic duct def: "An epithelium that is part of a pancreatic duct." [] synonym: "pancreatic duct epithelium" EXACT [] synonym: "pancreatic ductal epithelium" EXACT [] is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0013697 ! exocrine pancreas epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0007329 ! pancreatic duct relationship: develops_from UBERON:0000924 ! ectoderm relationship: part_of UBERON:0007329 ! pancreatic duct [Term] id: UBERON:0009971 name: principal gastric gland def: "one of the gastric glands that secretes the hydrochloric acid of the gastric juice[Stedman's]." [] synonym: "acid gland" EXACT [] synonym: "gastric follicle" RELATED [] synonym: "gastric gland" BROAD [] synonym: "glandula gastrica propria" EXACT [] synonym: "main gastric gland" EXACT [] synonym: "oxyntic gland" EXACT [] synonym: "principal gland of fundus of stomach" EXACT [] synonym: "Wassman gland" RELATED [] is_a: UBERON:0000325 ! gastric gland [Term] id: UBERON:0010000 name: multicellular anatomical structure def: "An anatomical structure that has more than one cell as a part." [] synonym: "multicellular structure" EXACT [] is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0000468 ! multi-cellular organism [Term] id: UBERON:0010009 name: aggregate regional part of brain def: "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." [] synonym: "set of nuclei of neuraxis" EXACT [] is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0010011 name: collection of basal ganglia def: "Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum." [] synonym: "basal ganglia" EXACT [] synonym: "basal ganglia set" EXACT [] synonym: "set of basal ganglia" EXACT [] is_a: UBERON:0010009 ! aggregate regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0010038 name: fundic gastric gland def: "The fundus glands (or fundic glands, or gastric glands) are found in the body and fundus of the stomach. They are simple tubes, two or more of which open into a single duct." [] synonym: "fundal gland" EXACT [] synonym: "fundus gland" EXACT [] synonym: "gastric fundal gland" EXACT [] synonym: "gastric fundus gland" EXACT [] synonym: "gastric gland of fundus of stomach" EXACT [] synonym: "glandulae gastricae" RELATED [] is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland intersection_of: UBERON:0000325 ! gastric gland intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach [Term] id: UBERON:0010039 name: food storage organ def: "An organ of the digestive tract that is capable of retaining and storing food" [] is_a: UBERON:0013765 ! digestive system organ relationship: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0010042 name: 1st arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 1." [] synonym: "mesenchyme of 1st arch" EXACT [] is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0004362 ! pharyngeal arch 1 relationship: part_of UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0010045 name: 1st arch maxillary mesenchyme def: "Mesenchyme that is part of a 1st arch maxillary component." [] synonym: "maxillary component mesenchyme" RELATED [] synonym: "maxillary mesenchyme" RELATED [] synonym: "mesenchyme of maxillary component" EXACT [] is_a: UBERON:0010042 ! 1st arch mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0007238 ! 1st arch maxillary component relationship: part_of UBERON:0007238 ! 1st arch maxillary component [Term] id: UBERON:0010046 name: entire pharyngeal arch associated mesenchyme def: "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." [] synonym: "associated mesenchyme of pharyngeal region" EXACT [] synonym: "entire branchial arch associated mesenchyme" EXACT [] synonym: "pharyngeal arch associated mesenchyme" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0008814 ! pharyngeal system [Term] id: UBERON:0010047 name: oral gland def: "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." [] synonym: "buccal gland" EXACT [] synonym: "gland of oral opening" EXACT [] synonym: "gland of oral part of face" EXACT [] synonym: "gland of subdivision of mouth" EXACT [] synonym: "oral cavity gland" RELATED [] synonym: "oral opening gland" EXACT [] synonym: "oral part of face gland" EXACT [] synonym: "oral region gland" EXACT [] synonym: "subdivision of mouth gland" EXACT [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000165 ! mouth relationship: part_of UBERON:0000165 ! mouth [Term] id: UBERON:0010056 name: future tongue def: "A compound organ that has_potential_to_develop_into a tongue." [] is_a: UBERON:0003103 ! compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0013765 ! digestive system organ relationship: part_of UBERON:0000165 ! mouth [Term] id: UBERON:0010059 name: hypoglossal cord is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0010056 ! future tongue [Term] id: UBERON:0010064 name: open anatomical space def: "An anatomical space with at least one opening to another space or the exterior." [] is_a: UBERON:0000464 ! anatomical space [Term] id: UBERON:0010069 name: outer epithelial layer of tympanic membrane def: "A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane" [] synonym: "cuticular layer of tympanic membrane" EXACT [] synonym: "cuticular stratum of tympanic membrane" EXACT [] synonym: "outer cuticular layer of tympanic membrane" EXACT [] synonym: "outer layer of tympanic membrane" EXACT [] synonym: "tympanic membrane external acoustic meatus epithelial component" EXACT [] is_a: UBERON:0009647 ! tympanic membrane epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0009647 ! tympanic membrane epithelium intersection_of: part_of UBERON:0001352 ! external acoustic meatus relationship: part_of UBERON:0001352 ! external acoustic meatus [Term] id: UBERON:0010071 name: layer of tympanic membrane synonym: "tympanic membrane layer" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002364 ! tympanic membrane [Term] id: UBERON:0010077 name: cuboidal epithelium def: "An epithelium consisting of cuboidal epithelial cells." [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0010092 name: future metencephalon def: "A developing anatomical structure that has_potential_to_develop_into a metencephalon." [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0010131 name: conducting tissue of heart def: "conducting system of heart plus Purkinje fibers." [] synonym: "specialized conducting tissue of heart" EXACT [] synonym: "specialized muscle tissue of heart" EXACT [] is_a: UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0010133 name: neuroendocrine gland def: "An endocrine gland that is part of a nervous system." [] is_a: UBERON:0002368 ! endocrine gland intersection_of: UBERON:0002368 ! endocrine gland intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0010141 name: primitive sex cord of indifferent gonad def: "A sex cord that is part of a indifferent gonad." [] synonym: "indifferent sex cord" EXACT [] synonym: "primitive sex cords" EXACT [] is_a: UBERON:0004909 ! epithelium of gonad is_a: UBERON:0005295 ! sex cord intersection_of: UBERON:0005295 ! sex cord intersection_of: part_of UBERON:0009117 ! indifferent gonad relationship: develops_from UBERON:0005891 ! coelomic epithelium relationship: part_of UBERON:0009117 ! indifferent gonad [Term] id: UBERON:0010147 name: male accessory sex gland def: "Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male." [] synonym: "male accessory gland" RELATED [] is_a: UBERON:0005399 ! male reproductive gland relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0010186 name: male urethral gland def: "Any of the many glands that branch off the wall of the urethra of male mammals. The glands secrete mucus, which is incorporated into the semen, and are most numerous in the section of the urethra that runs through the penis. [WP,unvetted]." [] synonym: "gland of Littre" EXACT [] synonym: "gland of male urethra" EXACT [] synonym: "glandulae urethrales urethrae masculinae" RELATED [] synonym: "Littre's gland" EXACT [] synonym: "male urethra gland" EXACT [] synonym: "urethral gland (male)" EXACT [] is_a: UBERON:0001338 ! urethral gland is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0001338 ! urethral gland intersection_of: part_of UBERON:0001333 ! male urethra relationship: part_of UBERON:0001333 ! male urethra [Term] id: UBERON:0010187 name: female urethral gland def: "An urethral gland that is part of a female urethra." [] synonym: "female urethra gland" EXACT [] synonym: "gland of female urethra" EXACT [] synonym: "urethral gland (female)" EXACT [] is_a: UBERON:0001338 ! urethral gland is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001338 ! urethral gland intersection_of: part_of UBERON:0001334 ! female urethra relationship: part_of UBERON:0001334 ! female urethra [Term] id: UBERON:0010188 name: protuberance def: "A roughly circular bulge in a surface." [] is_a: UBERON:0003102 ! surface structure [Term] id: UBERON:0010191 name: aortic system is_a: UBERON:0000480 ! anatomical group [Term] id: UBERON:0010202 name: lateral line def: "The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [] synonym: "lateral lines" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0009128 ! lateral line placode relationship: part_of UBERON:0002540 ! lateral line system [Term] id: UBERON:0010225 name: thalamic complex def: "A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]." [] is_a: UBERON:0002784 ! regional part of diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0010226 name: future cardiac ventricle def: "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle." [] synonym: "presumptive cardiac ventricle heart tube" EXACT [] synonym: "primordial cardiac ventricle" EXACT [] synonym: "primordial ventricle" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0004141 ! heart tube [Term] id: UBERON:0010227 name: future cardiac atrium def: "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium." [] synonym: "presumptive atrium heart tube" EXACT [] synonym: "primordial atrium" EXACT [] synonym: "primordial cardiac atrium" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0004141 ! heart tube [Term] id: UBERON:0010230 name: eyeball of camera-type eye def: "The camera-type eye apart from its appendages/adnexa." [] synonym: "bulbus oculi" EXACT [] synonym: "eye" RELATED [] synonym: "eye globe" EXACT [] synonym: "eyeball" EXACT [] synonym: "globe" RELATED [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0010233 name: stroma of thyroid gland def: "the connective tissue that supports the lobules and follicles of the thyroid gland." [] synonym: "thyroid gland stroma" EXACT [] synonym: "thyroid stroma" EXACT [] is_a: UBERON:0003891 ! stroma is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0002046 ! thyroid gland [Term] id: UBERON:0010253 name: 1st arch maxillary mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." [] is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0002342 ! neural crest intersection_of: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme relationship: part_of UBERON:0010258 ! mesenchyme from rhombencephalic neural crest [Term] id: UBERON:0010254 name: 2nd arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme." [] synonym: "branchial arch 2 mesenchyme from neural crest" RELATED [] synonym: "neural crest derived arch 2 mesenchyme" EXACT [] synonym: "pharyngeal arch 2 mesenchyme from neural crest" EXACT [] is_a: UBERON:0005689 ! 2nd arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0002342 ! neural crest intersection_of: part_of UBERON:0005689 ! 2nd arch mesenchyme relationship: develops_from UBERON:0002342 ! neural crest relationship: develops_from UBERON:0007099 ! hyoid neural crest relationship: part_of UBERON:0005689 ! 2nd arch mesenchyme relationship: part_of UBERON:0010258 ! mesenchyme from rhombencephalic neural crest [Term] id: UBERON:0010258 name: mesenchyme from rhombencephalic neural crest def: "Mesenchyme that develops_from a rhombencephalon neural crest." [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0003852 ! rhombencephalon neural crest relationship: develops_from UBERON:0003852 ! rhombencephalon neural crest relationship: part_of UBERON:0007213 ! mesenchyme derived from head neural crest [Term] id: UBERON:0010259 name: 1st arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." [] synonym: "branchial arch 1 mesenchyme from neural crest" RELATED [] synonym: "mesenchyme derived from neural crest of mesenchyme of 1st arch" EXACT [] synonym: "neural crest derived arch 1 mesenchyme" EXACT [] synonym: "pharyngeal arch 1 mesenchyme from neural crest" EXACT [] is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0002342 ! neural crest intersection_of: part_of UBERON:0010042 ! 1st arch mesenchyme relationship: develops_from UBERON:0002342 ! neural crest relationship: develops_from UBERON:0003852 ! rhombencephalon neural crest relationship: part_of UBERON:0010042 ! 1st arch mesenchyme [Term] id: UBERON:0010260 name: umbilical blood vessel def: "One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Whartons jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta." [] synonym: "umbilical cord blood vessel" EXACT [] synonym: "umbilical cord blood vessels" RELATED [] synonym: "umbilical vasculature" RELATED [] synonym: "umbilical vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0010276 name: vertebral column opening def: "An anatomical conduit that is part of a vertebra." [] synonym: "vertebral conduit" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: part_of UBERON:0002412 ! vertebra relationship: part_of UBERON:0002412 ! vertebra [Term] id: UBERON:0010285 name: midbrain basal plate def: "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." [] synonym: "basal plate midbrain" EXACT [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003528 ! brain grey matter relationship: part_of UBERON:0009581 ! midbrain mantle layer relationship: part_of UBERON:0010286 ! midbrain neural tube [Term] id: UBERON:0010286 name: midbrain neural tube def: "Portion of neural tube that gives rise to the midbrain." [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0003080 ! anterior neural tube [Term] id: UBERON:0010291 name: layer of sclera def: "." [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001773 ! sclera [Term] id: UBERON:0010294 name: scleral endothelium def: "An endothelium that is part of a sclera." [] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010291 ! layer of sclera is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001773 ! sclera relationship: part_of UBERON:0001773 ! sclera [Term] id: UBERON:0010295 name: substantia propria of sclera def: "A stroma that is part of a sclera." [] synonym: "scleral stroma" EXACT [] synonym: "stroma of sclera" EXACT [] synonym: "subsantia propria" BROAD [] synonym: "subsantia propria sclerae" EXACT [] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0003891 ! stroma is_a: UBERON:0010291 ! layer of sclera intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0001773 ! sclera relationship: part_of UBERON:0001773 ! sclera [Term] id: UBERON:0010302 name: amnioserosa def: "a single extraembryonic epithelium, which closes the germband dorsally." [] synonym: "amnion-serosa" RELATED [] is_a: UBERON:0010303 ! extraembryonic epithelium [Term] id: UBERON:0010303 name: extraembryonic epithelium def: "An epithelium that is part of a extraembryonic structure." [] synonym: "extra-embryonic epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: UBERON:0010304 name: non-keratinized stratified squamous epithelium def: "Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus." [] synonym: "epithelium stratificatum squamosum noncornificatum" EXACT [] synonym: "nonkeratinizing stratified squamous epithelium" EXACT [] is_a: UBERON:0006915 ! stratified squamous epithelium [Term] id: UBERON:0010305 name: region of conjunctiva def: "The conjunctiva is divided into 3 parts." [] synonym: "conjunctiva subdivision" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000064 ! organ part intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva [Term] id: UBERON:0010312 name: immature eye def: "Developing anatomical structure that develops into the eyeball and associated structures." [] synonym: "future eye" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003071 ! eye primordium [Term] id: UBERON:0010313 name: neural crest-derived structure def: "An anatomical structure that develops from the neural crest." [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0002342 ! neural crest relationship: develops_from UBERON:0002342 ! neural crest [Term] id: UBERON:0010314 name: structure with developmental contribution from neural crest def: "An anatomical structure that has some part that develops from the neural crest." [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0010316 name: germ layer / neural crest is_a: UBERON:0005291 ! embryonic tissue relationship: develops_from UBERON:0002532 ! epiblast (generic) [Term] id: UBERON:0010321 name: skeletal element of eye region def: "A skeletal element that is part of a ocular region." [] synonym: "eye skeleton" RELATED [] synonym: "ocular skeleton" RELATED [] synonym: "skeletal element of ocular region" RELATED [] is_a: UBERON:0004765 ! skeletal element is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0004765 ! skeletal element intersection_of: part_of UBERON:0004088 ! ocular region relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0004088 ! ocular region relationship: part_of UBERON:0011156 ! facial skeleton [Term] id: UBERON:0010323 name: cranial skeletal system def: "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [] synonym: "cranial skeleton" NARROW [] synonym: "cranium" RELATED [] synonym: "osteocranium" NARROW [] is_a: UBERON:0000075 ! subdivision of skeletal system relationship: part_of UBERON:0011137 ! axial skeletal system [Term] id: UBERON:0010330 name: eyelid mesenchyme def: "Mesenchyme that is part of a eyelid." [] is_a: UBERON:0003314 ! eye mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0010333 name: extraembryonic membrane mesenchyme def: "Mesenchyme that is part of a extraembryonic membrane." [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm relationship: part_of UBERON:0005631 ! extraembryonic membrane [Term] id: UBERON:0010338 name: 1st arch maxillary mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." [] is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm intersection_of: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm relationship: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme [Term] id: UBERON:0010341 name: 1st arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." [] synonym: "mesenchyme derived from head mesoderm of mesenchyme of 1st arch" EXACT [] is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm intersection_of: part_of UBERON:0010042 ! 1st arch mesenchyme relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm relationship: part_of UBERON:0010042 ! 1st arch mesenchyme [Term] id: UBERON:0010343 name: 2nd arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme." [] synonym: "branchial arch 2 mesenchyme from head mesenchyme" RELATED [] synonym: "head mesenchyme derived arch 2 mesenchyme" EXACT [] synonym: "mesenchyme derived from head mesoderm of mesenchyme of 2nd arch" EXACT [] synonym: "pharyngeal arch 2 mesenchyme from head mesenchyme" EXACT [] is_a: UBERON:0005689 ! 2nd arch mesenchyme is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm intersection_of: part_of UBERON:0005689 ! 2nd arch mesenchyme relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm relationship: part_of UBERON:0005689 ! 2nd arch mesenchyme [Term] id: UBERON:0010359 name: pharyngeal arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." [] synonym: "arch mesenchyme from neural crest" EXACT [] synonym: "branchial arch mesenchyme from neural crest" EXACT [] synonym: "neural crest derived arch mesenchyme" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0002342 ! neural crest intersection_of: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme [Term] id: UBERON:0010360 name: pharyngeal arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." [] synonym: "arch mesenchyme from head mesenchyme" EXACT [] synonym: "branchial arch mesenchyme from head mesenchyme" EXACT [] synonym: "head mesenchyme derived arch mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm intersection_of: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme relationship: develops_from UBERON:0006904 ! head mesenchyme from mesoderm relationship: part_of UBERON:0010046 ! entire pharyngeal arch associated mesenchyme [Term] id: UBERON:0010363 name: endochondral element def: "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." [] synonym: "endochondral replacement element" EXACT [] is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0010364 name: dermal skeleton def: "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." [] synonym: "dermal skeletal system" RELATED [] synonym: "dermoskeleton" RELATED [] synonym: "desmoskeleton" RELATED [] synonym: "exoskeleton" BROAD [] is_a: UBERON:0010912 ! subdivision of skeleton [Term] id: UBERON:0010365 name: odontoid tissue def: "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla." [] synonym: "dental tissue" RELATED [] synonym: "odontogenic tissue" EXACT [] synonym: "tooth tissue" RELATED [] is_a: UBERON:0004755 ! skeletal tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0004755 ! skeletal tissue intersection_of: develops_from UBERON:0001763 ! odontogenic papilla intersection_of: part_of UBERON:0010364 ! dermal skeleton relationship: develops_from UBERON:0001763 ! odontogenic papilla relationship: part_of UBERON:0010364 ! dermal skeleton [Term] id: UBERON:0010366 name: conjunctival vasculature def: "A vasculature that is part of a conjunctiva." [] synonym: "conjunctival veins" EXACT [] synonym: "conjunctival veins set" EXACT [] synonym: "set of conjunctival veins" EXACT [] synonym: "venae conjunctivales" EXACT [] is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva [Term] id: UBERON:0010367 name: conjunctival vein def: "A vein that is part of a conjunctiva." [] synonym: "conjunctival blood vessel" BROAD [] is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0009141 ! craniocervical region vein intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0010366 ! conjunctival vasculature [Term] id: UBERON:0010368 name: pulmonary lobule def: "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0010371 name: ecto-epithelium def: "Epithelium that derives from the ectoderm. Examples: epithelium of acinus of lactiferous duct, subscapular lens epithelium, epithelium of posterior surface of cornea." [] synonym: "ectoderm-derived epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: develops_from UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0000924 ! ectoderm [Term] id: UBERON:0010375 name: pancreas dorsal primordium synonym: "dorsal pancreas" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0001048 ! primordium is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0003921 ! pancreas primordium [Term] id: UBERON:0010376 name: pancreas ventral primordium synonym: "ventral pancreas" RELATED [] is_a: UBERON:0001048 ! primordium is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0003921 ! pancreas primordium [Term] id: UBERON:0010377 name: mesenchyme from somatopleure def: "Mesenchyme that develops_from a somatopleure." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0004874 ! somatopleure intersection_of: part_of UBERON:0000922 ! embryo relationship: develops_from UBERON:0004874 ! somatopleure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0009142 ! entire embryonic mesenchyme [Term] id: UBERON:0010380 name: enteric nerve def: "A nerve that is part of a enteric nervous system." [] is_a: UBERON:0001021 ! nerve is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002005 ! enteric nervous system relationship: part_of UBERON:0002005 ! enteric nervous system [Term] id: UBERON:0010386 name: peyer's patch follicle def: "A lymphoid follicle that is part of a Peyer's patch." [] is_a: UBERON:0000444 ! lymphoid follicle intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0010395 name: lymph node primary follicle def: "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." [] synonym: "primary follicle of lymph node" EXACT [] is_a: UBERON:0010422 ! primary nodular lymphoid tissue is_a: UBERON:0010748 ! lymph node follicle intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0010409 name: eye surface is_a: UBERON:0003102 ! surface structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0010422 name: primary nodular lymphoid tissue def: "A lymphoid follicle containing naive B cells" [] synonym: "primary follicle" RELATED [] synonym: "primary lymphoid follicle" EXACT [] synonym: "primary lymphoid nodule" EXACT [] is_a: UBERON:0000444 ! lymphoid follicle [Term] id: UBERON:0010423 name: primary lymphoid nodule of tonsil def: "A primary nodular lymphoid tissue that is part of a tonsil." [] synonym: "lymphoid nodule of tonsil" RELATED [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0010498 name: pseudostratified columnar epithelium def: "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." [] is_a: UBERON:0000485 ! simple columnar epithelium [Term] id: UBERON:0010499 name: pseudostratified ciliated columnar epithelium def: "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." [] synonym: "epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)" EXACT [] is_a: UBERON:0007592 ! ciliated columnar epithelium is_a: UBERON:0010498 ! pseudostratified columnar epithelium [Term] id: UBERON:0010523 name: microcirculatory vessel def: "A portion of tissue that consists of a tube composed of epithelial cells that connects larger vessels." [] synonym: "microcirculatory vessels" RELATED [] is_a: UBERON:0000055 ! vessel relationship: part_of UBERON:0002049 ! vasculature [Term] id: UBERON:0010531 name: metanephros induced blastemal cells def: "." [] synonym: "cap mesenchyme of metanephros of urinary system" RELATED [] synonym: "induced blastemal cells" EXACT [] synonym: "nephrogenic interstitium" RELATED [] synonym: "nephrogenic interstitium of nephrogenic zone" EXACT [] synonym: "peripheral blastema" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0009871 ! nephrogenic zone [Term] id: UBERON:0010532 name: primitive nephron synonym: "developing nephron" BROAD [] synonym: "primitive nephron" BROAD [] is_a: UBERON:0001285 ! nephron is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006555 ! excretory tube relationship: develops_from UBERON:0004209 ! renal vesicle relationship: part_of UBERON:0003918 ! kidney mesenchyme [Term] id: UBERON:0010533 name: metanephros cortex def: "The metanephric cortex is the outer region of the metanephros[GO]." [] is_a: UBERON:0001225 ! cortex of kidney is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001225 ! cortex of kidney intersection_of: part_of UBERON:0000081 ! metanephros relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme relationship: part_of UBERON:0000081 ! metanephros [Term] id: UBERON:0010534 name: primitive mesonephric nephron def: "Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells." [] synonym: "developing mesonephric nephron" EXACT [] synonym: "primitive mesonephric nephron" EXACT [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0005322 ! mesonephric nephron is_a: UBERON:0010532 ! primitive nephron intersection_of: UBERON:0010532 ! primitive nephron intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros [Term] id: UBERON:0010535 name: primitive metanephric nephron def: "A primitive nephron that is part of a metanephros." [] synonym: "developing metanephric nephron" EXACT [] synonym: "primitive metanephric nephron" EXACT [] synonym: "primitive nephron" BROAD [] is_a: UBERON:0005106 ! metanephric tubule is_a: UBERON:0005110 ! metanephric nephron is_a: UBERON:0010532 ! primitive nephron intersection_of: UBERON:0010532 ! primitive nephron intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0005113 ! metanephric cortex mesenchyme [Term] id: UBERON:0010743 name: meningeal cluster def: "The collection of all meningeal layers that line a central nervous system." [] synonym: "cluster of meninges" EXACT [] synonym: "meninges" EXACT [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0010748 name: lymph node follicle def: "A lymphoid follicle that is part of a lymph node." [] synonym: "follicle of lymph node" EXACT [] is_a: UBERON:0000444 ! lymphoid follicle intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0002006 ! cortex of lymph node [Term] id: UBERON:0010753 name: lymph node secondary follicle def: "A secondary follicle that is located in a lymph node" [] is_a: UBERON:0001745 ! secondary nodular lymphoid tissue is_a: UBERON:0010748 ! lymph node follicle intersection_of: UBERON:0001745 ! secondary nodular lymphoid tissue intersection_of: part_of UBERON:0000029 ! lymph node relationship: develops_from UBERON:0010395 ! lymph node primary follicle relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0010912 name: subdivision of skeleton def: "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." [] synonym: "skeletal subdivision" EXACT [] synonym: "subdivision of skeleton (in vivo)" RELATED [] is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0000075 ! subdivision of skeletal system relationship: part_of UBERON:0004288 ! skeleton [Term] id: UBERON:0010913 name: vertebral element def: "Skeletal element that forms around the notochord and is part of the vertebral column." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004765 ! skeletal element relationship: develops_from UBERON:0003089 ! sclerotome relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0010959 name: craniocervical muscle def: "A muscle organ that is part of a craniocervical region." [] synonym: "muscle of head and neck" RELATED [] synonym: "muscle of head or neck" EXACT [] is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0008229 ! craniocervical region musculature [Term] id: UBERON:0010996 name: articular cartilage of joint def: "A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints." [] synonym: "articular cartilage" EXACT [] synonym: "cartilago articularis" EXACT [] synonym: "hyaline cartilage" RELATED [] synonym: "joint-associated cartilage" RELATED [] is_a: UBERON:0001994 ! hyaline cartilage tissue relationship: part_of UBERON:0002217 ! synovial joint [Term] id: UBERON:0011094 name: vertebra cartilage element def: "A cartilaginous condensation that is part of a vertebral column." [] synonym: "vertebral cartilage condensation" EXACT [] is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010913 ! vertebral element is_a: UBERON:0015005 ! vertebra endochondral element intersection_of: UBERON:0005863 ! cartilaginous condensation intersection_of: part_of UBERON:0001130 ! vertebral column relationship: develops_from UBERON:0011095 ! vertebra pre-cartilage condensation relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0011095 name: vertebra pre-cartilage condensation def: "A pre-cartilage condensation that is part of a vertebral column." [] synonym: "vertebral pre-cartilage condensation" EXACT [] is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015005 ! vertebra endochondral element intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: part_of UBERON:0001130 ! vertebral column relationship: develops_from UBERON:0003089 ! sclerotome relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0011134 name: nonsynovial joint def: "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." [] synonym: "solid joint" EXACT [] is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0011135 name: intervertebral cartilage def: "A cartilage element that lies between two successive vertebral centra." [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007844 ! cartilage element relationship: part_of UBERON:0001468 ! intervertebral joint [Term] id: UBERON:0011137 name: axial skeletal system def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." [] is_a: UBERON:0000075 ! subdivision of skeletal system [Term] id: UBERON:0011138 name: post-cranial axial skeletal system def: "Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints." [] synonym: "axial skeletal system" BROAD [] is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0003089 ! sclerotome [Term] id: UBERON:0011143 name: upper urinary tract def: "Subdivision of urinary system which consists of the kidney and the ureters." [] is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0006554 ! urinary system structure relationship: part_of UBERON:0001008 ! renal system [Term] id: UBERON:0011148 name: submucosal gland def: "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." [] is_a: UBERON:0000414 ! mucous gland [Term] id: UBERON:0011156 name: facial skeleton def: "Subdivision of skull that consists of the facial bones." [] synonym: "facial bone" RELATED [] synonym: "facial skeleton" EXACT [] synonym: "ossa facialia" RELATED [] synonym: "ossa faciei" RELATED [] synonym: "viscerocranium" RELATED [] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011158 ! primary subdivision of skull relationship: develops_from UBERON:0002342 ! neural crest relationship: part_of UBERON:0001456 ! face [Term] id: UBERON:0011158 name: primary subdivision of skull def: "The skull can be divided into two: the neurocranium and the facial skeleton" [] synonym: "skull subdivision" EXACT [] synonym: "subdivision of skull" EXACT [] is_a: UBERON:0000075 ! subdivision of skeletal system relationship: part_of UBERON:0003129 ! skull [Term] id: UBERON:0011159 name: primary subdivision of cranial skeletal system is_a: UBERON:0000075 ! subdivision of skeletal system relationship: part_of UBERON:0010323 ! cranial skeletal system [Term] id: UBERON:0011164 name: neurocranium bone def: "A bone that is part of a neurocranium [Automatically generated definition]." [] synonym: "chondrocranium bone" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004766 ! cranial bone intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0001703 ! neurocranium relationship: part_of UBERON:0001703 ! neurocranium [Term] id: UBERON:0011184 name: epithelium of crypt of lieberkuhn def: "An epithelium that is part of a crypt of Lieberkuhn." [] synonym: "crypt epithelium" BROAD [] synonym: "intestinal crypt epithelium" EXACT [] is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn [Term] id: UBERON:0011185 name: gastrointestinal sphincter def: "A sphincter muscle that is part of the gastrointestinal system" [] is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0013765 ! digestive system organ intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0005409 ! gastrointestinal system relationship: part_of UBERON:0005409 ! gastrointestinal system [Term] id: UBERON:0011189 name: lamina propria of large intestine def: "A lamina propria that is part of a large intestine." [] synonym: "lamina propria of mucosa of large intestine" EXACT [] synonym: "large intestinal lamina propria" EXACT [] synonym: "large intestine lamina propria" EXACT [] is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine relationship: part_of UBERON:0001207 ! mucosa of large intestine [Term] id: UBERON:0011197 name: parathyroid epithelium def: "An epithelium that is part of a parathyroid gland." [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: develops_from UBERON:0004117 ! pharyngeal pouch relationship: part_of UBERON:0001132 ! parathyroid gland [Term] id: UBERON:0011198 name: muscle layer of large intestine def: "A muscle layer that is part of a large intestine." [] synonym: "muscular coat of large intestine" EXACT [] synonym: "muscular layer of large intestine" EXACT [] synonym: "muscularis externa of large intestine" EXACT [] synonym: "tunica muscularis intestini crassi" EXACT [] is_a: UBERON:0012367 ! muscle layer of intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine [Term] id: UBERON:0011201 name: muscle layer of small intestine def: "A muscle layer that is part of a small intestine." [] synonym: "muscular coat of small intestine" EXACT [] synonym: "muscular layer of small intestine" EXACT [] synonym: "muscularis externa of small intestine" EXACT [] synonym: "small intestine muscularis propria" EXACT [] synonym: "tunica muscularis (intestinum tenue)" EXACT [] synonym: "tunica muscularis intestini tenuis" EXACT [] is_a: UBERON:0012367 ! muscle layer of intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0011215 name: cell part cluster of neuraxis def: "A multi cell component structure that is part of a central nervous system." [] synonym: "neuraxis layer" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005162 ! multi cell component structure intersection_of: UBERON:0005162 ! multi cell component structure intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: UBERON:0011216 name: organ system subdivision def: "Anatomical structure, which consists of a specific set of the members of (predominantly) one organ or organ part subclass interconnected by zones of continuity or body substances; is demarcated from other subdivisions of the same organ system by one or more zones of continuity or anatomical lines; together with other subdivisions of the same organ system, it constitutes an organ system. Examples: rib cage, facial skeleton, portal system, central nervous system, upper respiratory tract, muscle group of back." [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0000467 ! anatomical system [Term] id: UBERON:0011222 name: intra-ocular muscle synonym: "intrinsic muscle of eyeball" EXACT [] synonym: "intrinsic ocular muscle" EXACT [] is_a: UBERON:0004277 ! eye muscle relationship: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0003386 ! smooth muscle of eye [Term] id: UBERON:0011249 name: appendicular skeletal system def: "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." [] is_a: UBERON:0000075 ! subdivision of skeletal system [Term] id: UBERON:0011272 name: embryonic skin basal layer synonym: "basal cell layer of skin" RELATED [] synonym: "outer epithelium of body" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0002199 ! integument [Term] id: UBERON:0011298 name: submucosa of uterine tube def: "The submucous layer of the wall of the uterine tube." [] synonym: "submucosa of fallopian tube" EXACT [] synonym: "submucous layer of uterine tube" RELATED [] synonym: "tela submucosa tubae uterinae" EXACT [] synonym: "uterine submucosa" RELATED [] is_a: UBERON:0000009 ! submucosa is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0003889 ! fallopian tube relationship: part_of UBERON:0003889 ! fallopian tube [Term] id: UBERON:0011300 name: gray matter of telencephalon def: "A portion of gray matter of neuraxis that is part of a telencephalon." [] is_a: UBERON:0003528 ! brain grey matter is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0002020 ! gray matter of neuraxis intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] id: UBERON:0011332 name: extrinsic tongue pre-muscle mass is_a: UBERON:0003416 ! mesenchyme of tongue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005865 ! pre-muscle condensation relationship: part_of UBERON:0003273 ! skeletal muscle tissue of tongue [Term] id: UBERON:0011362 name: cranial blood vasculature def: "A blood vasculature that is part of a head." [] synonym: "cranial blood vessels" RELATED [] synonym: "set of blood vessels of head" EXACT [] is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004537 ! blood vasculature intersection_of: UBERON:0004537 ! blood vasculature intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0011363 name: cranial lymph vasculature def: "A lymph vasculature that is part of a head." [] synonym: "cranial lymph vessels" RELATED [] synonym: "set of lymphatic vessels of head" EXACT [] is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004536 ! lymph vasculature intersection_of: UBERON:0004536 ! lymph vasculature intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0011374 name: prepuce is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0005156 ! reproductive structure relationship: part_of UBERON:0005156 ! reproductive structure [Term] id: UBERON:0011585 name: cell condensation def: "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0011587 name: pre-dentine def: "Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix." [] synonym: "pre-dentine tissue" EXACT [] synonym: "predentin" EXACT [] synonym: "predentine tissue" EXACT [] is_a: UBERON:0010365 ! odontoid tissue relationship: develops_from UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0002342 ! neural crest [Term] id: UBERON:0011588 name: pre-enamel def: "Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix." [] synonym: "pre-enamel tissue" EXACT [] synonym: "preenamel tissue" EXACT [] is_a: UBERON:0010365 ! odontoid tissue [Term] id: UBERON:0011589 name: non-mineralized cartilage tissue def: "Cartilage tissue that is not mineralized." [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0011595 name: jaw region is_a: UBERON:0000477 ! anatomical cluster is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000165 ! mouth [Term] id: UBERON:0011642 name: oral epithelium from ectoderm def: "An epithelium that develops_from a ectoderm and is part of a oral epithelium." [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0002424 ! oral epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: develops_from UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0009479 ! ectoderm of buccopharyngeal membrane relationship: part_of UBERON:0002424 ! oral epithelium [Term] id: UBERON:0011676 name: subdivision of organism along main body axis def: "A major subdivision of an organism that divides an organism along its anterio-posterior axis. In vertebrates, this is based on the vertebral column." [] synonym: "axial subdivision of organism" EXACT [] synonym: "body segment" RELATED [] synonym: "main body segment" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0013701 ! main body axis [Term] id: UBERON:0011695 name: embryonic cardiovascular system def: "A cardiovascular system that is part of a conceptus." [] synonym: "conceptus cardiovascular system" EXACT [] synonym: "embryonic circulatory system" RELATED [] synonym: "fetal circulatory system" RELATED [] is_a: UBERON:0004535 ! cardiovascular system intersection_of: UBERON:0004535 ! cardiovascular system intersection_of: part_of UBERON:0004716 ! conceptus relationship: part_of UBERON:0004716 ! conceptus [Term] id: UBERON:0011777 name: nucleus of spinal cord def: "Nucleus of neuraxis which is located within the spinal cord. Example: dorsal nucleus of Clarke, Intermediolateral nucleus." [] synonym: "spinal cord nucleus" EXACT [] is_a: UBERON:0000125 ! neural nucleus is_a: UBERON:0001948 ! regional part of spinal cord intersection_of: UBERON:0000125 ! neural nucleus intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0011779 name: nerve of head region def: "A nerve that is part of a head." [] synonym: "cephalic nerve" RELATED [] synonym: "head nerve" RELATED [] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0011814 name: non-neurogenic ectodermal placode is_a: UBERON:0005085 ! ectodermal placode [Term] id: UBERON:0011817 name: follicle placode is_a: UBERON:0011814 ! non-neurogenic ectodermal placode [Term] id: UBERON:0011821 name: irregular connective tissue def: "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0011823 name: dense connective tissue def: "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets" [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0011825 name: loose connective tissue def: "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." [] is_a: UBERON:0011821 ! irregular connective tissue [Term] id: UBERON:0011845 name: duct of sebaceous gland def: "A duct that is part of a sebaceous gland." [] synonym: "sebaceous gland duct" EXACT [] is_a: UBERON:0000058 ! duct is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland [Term] id: UBERON:0011846 name: acinus of sebaceous gland def: "An acinus that is part of a sebaceous gland." [] synonym: "sebaceous gland acinus" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! acinus intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland [Term] id: UBERON:0011850 name: acinus of salivary gland def: "An acinus that is part of a salivary gland." [] synonym: "salivary gland acinus" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! acinus intersection_of: part_of UBERON:0001044 ! salivary gland relationship: part_of UBERON:0001044 ! salivary gland [Term] id: UBERON:0011856 name: acinus of lactiferous gland def: "An acinus that is part of a mammary gland." [] synonym: "lactiferous gland acinus" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0011858 ! acinus of exocrine gland is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0009842 ! acinus intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001912 ! lobule of lactiferous gland [Term] id: UBERON:0011858 name: acinus of exocrine gland def: "An acinus that is part of a exocrine gland." [] synonym: "exocrine gland acinus" EXACT [] is_a: UBERON:0009842 ! acinus intersection_of: UBERON:0009842 ! acinus intersection_of: part_of UBERON:0002365 ! exocrine gland relationship: part_of UBERON:0002365 ! exocrine gland [Term] id: UBERON:0011878 name: muscle layer of esophagus def: "A muscle layer that is part of a wall of esophagus." [] synonym: "muscle coat of esophagus" EXACT [] synonym: "muscular coat of oesophagus" EXACT [] synonym: "muscular layer of oesophagus" EXACT [] synonym: "tunica muscularis esophagi" EXACT [] synonym: "tunica muscularis oesophageae" EXACT [] is_a: UBERON:0006660 ! muscle layer intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0011892 name: anterior uvea def: "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." [] synonym: "anterior part of uveal tract" EXACT [] synonym: "anterior uveal tract" EXACT [] synonym: "anterior vascular layer of the eyeball" EXACT [] synonym: "anterior vascular tunic of the eye" EXACT [] synonym: "ciliary body and iris" RELATED [] synonym: "Haller tunica vascula" EXACT [] synonym: "tunica vasculosa bulbosa" EXACT [] synonym: "vasculosa oculi" RELATED [] synonym: "ventral uveal tract" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001768 ! uvea relationship: part_of UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0011919 name: yolk sac blood island def: "masses of developing blood cells attached to endothelium in the yolk sac" [] synonym: "visceral yolk sac blood island" EXACT [] synonym: "yolk sac blood islands" EXACT [] is_a: UBERON:0003061 ! blood island intersection_of: UBERON:0003061 ! blood island intersection_of: part_of UBERON:0003316 ! mesenchyme of yolk sac relationship: develops_from UBERON:0003316 ! mesenchyme of yolk sac relationship: part_of UBERON:0003316 ! mesenchyme of yolk sac [Term] id: UBERON:0011932 name: pilosebaceous unit def: "An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle" [] synonym: "fabrica pilosebacea" EXACT [] synonym: "pilo-sebaceous apparatus" EXACT [] synonym: "pilo-sebaceous unit" EXACT [] synonym: "pilosebaceous apparatus" EXACT [] is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0011953 name: stomach glandular region def: "A stomach region that has_part a stomach glandular epithelium." [] synonym: "glandular stomach" RELATED [] is_a: UBERON:0009034 ! stomach region [Term] id: UBERON:0011997 name: coelom def: "The structure that contains the coelemic cavity." [] synonym: "coelem" RELATED [] synonym: "coelomic cavity" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0012069 name: epithelium-associated lymphoid tissue is_a: UBERON:0001744 ! lymphoid tissue [Term] id: UBERON:0012175 name: acoustico-facial VII-VIII ganglion complex synonym: "facio-acoustic ganglion complex VII-VIII" EXACT [] synonym: "facio-acoustic VII-VIII ganglion complex" RELATED [] is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0003051 ! ear vesicle relationship: develops_from UBERON:0006232 ! facio-acoustic VII-VIII preganglion complex [Term] id: UBERON:0012239 name: urinary bladder vasculature def: "network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]" [] synonym: "bladder vasculature" EXACT [] synonym: "blood vessels of bladder" EXACT [] synonym: "set of urinary bladder blood vessels" EXACT [] is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder [Term] id: UBERON:0012247 name: cervical gland def: "mucus-secreting glands in the mucosa of the uterine cervix" [] synonym: "glandulae cervicales" EXACT [] is_a: UBERON:0000414 ! mucous gland is_a: UBERON:0005398 ! female reproductive gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0012248 ! cervical mucosa [Term] id: UBERON:0012248 name: cervical mucosa def: "Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing." [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix [Term] id: UBERON:0012250 name: cervix glandular epithelium synonym: "cervix columnar epithelium" RELATED [] is_a: UBERON:0004801 ! cervix epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0006799 ! glandular epithelium intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix [Term] id: UBERON:0012252 name: endocervical epithelium def: "The glandular epithelium that lines the endocervix." [] synonym: "endocervical glandular epithelium" EXACT [] is_a: UBERON:0012250 ! cervix glandular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000458 ! endocervix relationship: part_of UBERON:0000458 ! endocervix [Term] id: UBERON:0012274 name: columnar epithelium def: "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]" [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0012275 name: meso-epithelium def: "Epithelium that derives from the mesoderm. [Automatically generated definition]." [] synonym: "mesoderm-derived epithelium" EXACT [] synonym: "mesoepithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000926 ! mesoderm [Term] id: UBERON:0012278 name: nasal gland def: "The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands." [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0000004 ! olfactory apparatus relationship: part_of UBERON:0002330 ! exocrine system [Term] id: UBERON:0012279 name: paraganglion def: "Small bodies containing chromaffin cells occurring outside of the adrenal medulla, most commonly near the sympathetic ganglia and in organs such as the kidney, liver, heart and gonads." [] synonym: "chromaffin body" RELATED [] synonym: "chromaffin paraganglia" RELATED [] synonym: "chromaffin paraganglion" RELATED [] is_a: UBERON:0000480 ! anatomical group is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0012281 name: perianal gland def: "A gland located in the area around the anus." [] synonym: "circumanal gland" RELATED [] synonym: "perianal gland" RELATED [] is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0012292 name: embryonic cloacal fold def: "One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly" [] synonym: "cloacal fold" BROAD [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0012469 ! external anal region [Term] id: UBERON:0012299 name: mucosa of urethra synonym: "mucous membrane of urethra" EXACT [] synonym: "tunica mucosa urethrae" EXACT [] synonym: "urethral mucosa" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: UBERON:0012313 name: 1st arch maxillary ectoderm synonym: "ectoderm of maxillary component" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: develops_from UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0007238 ! 1st arch maxillary component [Term] id: UBERON:0012314 name: embryonic facial prominence def: "One of five swellings formed during the development of the face" [] synonym: "embryonic facial process" RELATED [] synonym: "facial primordium" RELATED [] synonym: "primordium of face" RELATED [] is_a: UBERON:0005423 ! developing anatomical structure relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000922 ! embryo [Term] id: UBERON:0012320 name: cervical artery def: "An artery of the neck" [] is_a: UBERON:0001637 ! artery is_a: UBERON:0003502 ! neck blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0012330 name: nasal-associated lymphoid tissue def: "The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals." [] synonym: "NALT" RELATED [] synonym: "naso-pharyngeal lymphoid tissue" EXACT [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx [Term] id: UBERON:0012332 name: broad ligament of uterus def: "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis[MESH]." [] synonym: "broad ligament" RELATED [] synonym: "broad uterine ligament" EXACT [] is_a: UBERON:0000211 ! ligament is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002095 ! mesentery [Term] id: UBERON:0012344 name: holocrine gland def: "A gland whose discharged secretion contains entire secreting cells." [] is_a: UBERON:0002530 ! gland [Term] id: UBERON:0012360 name: bone of jaw synonym: "jaw bone" EXACT [] is_a: UBERON:0003462 ! facial bone is_a: UBERON:0013765 ! digestive system organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0011595 ! jaw region relationship: part_of UBERON:0001708 ! jaw skeleton relationship: part_of UBERON:0011595 ! jaw region [Term] id: UBERON:0012361 name: internal anal region is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0012367 name: muscle layer of intestine def: "A muscle layer that is part of an intestine." [] synonym: "intestinal muscularis propria" EXACT [] synonym: "muscularis externa of intestine" EXACT [] synonym: "smooth muscle of intestine" RELATED [] is_a: UBERON:0006660 ! muscle layer intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0012377 name: muscle layer of jejunum synonym: "jejunal smooth muscle" RELATED [] synonym: "muscularis externa of jejunum" EXACT [] synonym: "muscularis propria of jejunum" RELATED [] synonym: "smooth muscle of jejunum" RELATED [] is_a: UBERON:0011201 ! muscle layer of small intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0012378 name: muscle layer of urinary bladder synonym: "bladder muscular coat" EXACT [] synonym: "muscle layer of urinary bladder" EXACT [] synonym: "muscular coat of bladder" EXACT [] synonym: "muscular coat of urinary bladder" EXACT [] synonym: "muscular layer of bladder" EXACT [] synonym: "muscular layer of urinary bladder" EXACT [] synonym: "tunica musculari vesicae" EXACT [] synonym: "tunica muscularis (vesica urinaria)" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006554 ! urinary system structure is_a: UBERON:0006660 ! muscle layer intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 ! wall of urinary bladder [Term] id: UBERON:0012416 name: respiratory system arterial smooth muscle is_a: UBERON:0004297 ! respiratory system blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003643 ! respiratory system arterial blood vessel relationship: part_of UBERON:0003643 ! respiratory system arterial blood vessel [Term] id: UBERON:0012418 name: respiratory system venous smooth muscle is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003476 ! respiratory system venous blood vessel relationship: part_of UBERON:0003476 ! respiratory system venous blood vessel [Term] id: UBERON:0012429 name: hemopoietic tissue def: "Blood-forming tissue, consisting of reticular fibers and cells. Also known as hemopoietic tissue" [] synonym: "bone marrow tissue" NARROW [] synonym: "haemopoietic tissue" EXACT [] synonym: "hematopoietic tissue" EXACT [] synonym: "textus haemopoieticus" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002390 ! hematopoietic system [Term] id: UBERON:0012430 name: tunica fibrosa of eyeball synonym: "fibrous layer of eyeball" EXACT [] synonym: "tunica fibrosa" BROAD [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0010230 ! eyeball of camera-type eye [Term] id: UBERON:0012441 name: endothelium of peritubular capillary synonym: "peritubular capillary endothelium" EXACT [] synonym: "peritubular endothelium" BROAD [] is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0005272 ! peritubular capillary relationship: part_of UBERON:0005272 ! peritubular capillary [Term] id: UBERON:0012467 name: enclosed anatomical space def: "An anatomical space with no opening to another space or to the exterior." [] synonym: "closed anatomical space" EXACT [] is_a: UBERON:0000464 ! anatomical space [Term] id: UBERON:0012468 name: anal tooth def: "Tooth-like structure that typically forms a ring surrounding the anus of some Holothuriidae" [] synonym: "anal teeth" EXACT [] synonym: "cloacal tooth" RELATED [] synonym: "perianal tooth" RELATED [] is_a: UBERON:0003913 ! tooth-like structure intersection_of: UBERON:0003913 ! tooth-like structure intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0012469 name: external anal region is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0012478 name: cloacal gland is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0012480 name: cloacal mucosa def: "A mucosa that is part of a cloaca [Automatically generated definition]." [] synonym: "cloaca mucosa" EXACT [] synonym: "cloaca mucosa of organ" EXACT [] synonym: "cloaca mucous membrane" EXACT [] synonym: "cloaca organ mucosa" EXACT [] synonym: "cloacal mucous membrane" EXACT [] synonym: "mucosa of cloaca" EXACT [] synonym: "mucosa of organ of cloaca" EXACT [] synonym: "mucous membrane of cloaca" EXACT [] synonym: "organ mucosa of cloaca" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0012481 name: cloacal epithelium def: "An epithelium that is part of a cloaca." [] is_a: UBERON:0003929 ! gut epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0012482 name: submucosa of cloaca def: "A submucosa that is part of a cloaca [Automatically generated definition]." [] synonym: "cloaca submucosa" EXACT [] synonym: "cloacal submucosa" EXACT [] is_a: UBERON:0000009 ! submucosa is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0012483 name: serosa of cloaca def: "A serous membrane that is part of a cloaca [Automatically generated definition]." [] synonym: "cloaca serosa" EXACT [] synonym: "cloaca serous membrane" EXACT [] synonym: "cloacal serosa" EXACT [] synonym: "serous membrane of cloaca" EXACT [] synonym: "visceral peritoneum of cloaca" EXACT [] is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0012486 name: muscle layer of cloaca synonym: "muscularis externa of cloaca" EXACT [] synonym: "smooth muscle of cloaca" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006660 ! muscle layer intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0012487 name: vaginal sphincter synonym: "sphincter of vagina" EXACT [] is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0012488 name: muscle layer of duodenum synonym: "duodenal muscularis propria" EXACT [] synonym: "muscularis externa of duodenum" EXACT [] synonym: "muscularis propria of duodenum" RELATED [] synonym: "smooth muscle of duodenum" RELATED [] is_a: UBERON:0011201 ! muscle layer of small intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: UBERON:0012489 name: muscle layer of colon synonym: "colonic muscularis propria" EXACT [] synonym: "muscular coat of colon" EXACT [] synonym: "muscular layer of colon" EXACT [] synonym: "muscularis externa of colon" EXACT [] synonym: "tunica muscularis coli" EXACT [] is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0012490 name: muscle layer of anal canal synonym: "anal canal muscularis propria" EXACT [] synonym: "anal muscularis propria" EXACT [] synonym: "muscular coat of anal canal" EXACT [] synonym: "muscular layer of anal canal" EXACT [] synonym: "muscularis externa of anal canal" EXACT [] synonym: "muscularis propria of anal canal" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal [Term] id: UBERON:0012498 name: serosa of appendix synonym: "appendiceal serosa" EXACT [] synonym: "appendix serosa" EXACT [] synonym: "serosa of vermiform appendix" EXACT [] synonym: "visceral peritoneum of vermiform appendix" EXACT [] is_a: UBERON:0003335 ! serosa of colon intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: UBERON:0012499 name: serosa of uterine tube synonym: "serosa of fallopian tube" EXACT [] synonym: "serosa of oviduct" EXACT [] synonym: "serous coat of uterine tube" EXACT [] synonym: "tunica serosa (tuba uterina)" EXACT [] synonym: "tunica serosa tubae uterinae" EXACT [] synonym: "uterine tubal serosa" EXACT [] synonym: "uterine tube serosa" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0003889 ! fallopian tube relationship: part_of UBERON:0003889 ! fallopian tube [Term] id: UBERON:0012503 name: serosa of fundus of stomach synonym: "visceral peritoneum of fundus of stomach" EXACT [] is_a: UBERON:0001201 ! serosa of stomach intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001201 ! serosa of stomach [Term] id: UBERON:0012504 name: adventitia of esophagus synonym: "adventitia of oesophagus" EXACT [] synonym: "adventitious layer of esophagus" EXACT [] synonym: "esophageal adventitia" EXACT [] synonym: "esophagus adventitia" EXACT [] synonym: "tunica adventitia (esophagus)" EXACT [] synonym: "tunica adventitia oesophageae" EXACT [] is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus [Term] id: UBERON:0012615 name: umbilical smooth muscle is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0002331 ! umbilical cord [Term] id: UBERON:0013126 name: vein of abdomen synonym: "abdominal vein" EXACT [] is_a: UBERON:0001638 ! vein is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0013140 name: systemic vein def: "Any vein within the general circulation that transports blood back to the right atrium of the heart." [] synonym: "systemic venous tree organ part" EXACT [] is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0004581 ! systemic venous system relationship: part_of UBERON:0004581 ! systemic venous system [Term] id: UBERON:0013149 name: hindbrain vesicle synonym: "rhombencephalic vesicle" EXACT [] is_a: UBERON:0013150 ! future brain vesicle [Term] id: UBERON:0013150 name: future brain vesicle synonym: "brain vesicle" RELATED [] synonym: "early brain vesicle" EXACT [] synonym: "primary brain vesicle" NARROW [] synonym: "primitive brain vesicle" EXACT [] synonym: "secondary brain vesicle" NARROW [] is_a: UBERON:0010064 ! open anatomical space relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0005281 ! ventricular system of central nervous system [Term] id: UBERON:0013158 name: foregut-midgut junction gland synonym: "gland of foregut-midgut junction" EXACT [] is_a: UBERON:0003408 ! gland of gut intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction [Term] id: UBERON:0013191 name: ovarian cortex def: "The outer layer of the ovary, composed of cellular connective tissue which contains the ovarian follicles" [] synonym: "cortex of ovary" EXACT [] synonym: "cortex ovarii (zona parenchymatosa)" EXACT [] is_a: UBERON:0001851 ! cortex is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0001851 ! cortex intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0013192 name: ovarian medulla def: "The medulla of ovary (or Zona vasculosa of Waldeyer) is a highly vascular stroma in the center of the ovary. It forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves. This stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter: it does not contain any ovarian follicles." [] synonym: "medulla of ovary" EXACT [] synonym: "medulla ovarii (zona vasculosa)" EXACT [] synonym: "zona vasculosa of Waldeyer" RELATED [] is_a: UBERON:0000958 ! medulla is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014404 ! female anatomical structure intersection_of: UBERON:0000958 ! medulla intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: UBERON:0013229 name: eyelid gland def: "Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland)." [] synonym: "gland of eyelid" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004859 ! eye gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0013231 name: sebaceous gland of eyelid def: "Glands of Zeis are unilobar sebaceous glands located on the margin of the eyelid. The glands of Zeis service the eyelash. These glands produce an oily substance that is issued through the excretory ducts of the sebaceous lobule into the middle portion of the hair follicle. In the same area of the eyelid, near the base of the eyelashes are sweat glands called the 'glands of Moll'. If eyelashes are not kept clean, conditions such as folliculitis may take place, and if the sebaceous gland becomes infected, it can lead to abscesses and styes. The glands of Zeis are named after German ophthalmologist Eduard Zeis (1807b68)." [] synonym: "ciliary sebaceous gland of eyelid" EXACT [] synonym: "gland of Zeis" EXACT [] synonym: "gland of Zeiss" EXACT [] is_a: UBERON:0003484 ! eye sebaceous gland is_a: UBERON:0013229 ! eyelid gland intersection_of: UBERON:0001821 ! sebaceous gland intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0013241 name: embryonic urethral groove def: "The urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. In humans, it typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week." [] synonym: "sulcus urethralis primarius" EXACT [] synonym: "urethral groove" EXACT [] synonym: "urethral sulcus" EXACT [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0014403 ! male anatomical structure relationship: develops_from UBERON:0004876 ! urogenital ridge relationship: part_of UBERON:0000989 ! penis [Term] id: UBERON:0013247 name: male paramesonephric duct synonym: "degenerating mesonephric portion of male paramesonephric duct" RELATED [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0014403 ! male anatomical structure intersection_of: UBERON:0003914 ! epithelial tube intersection_of: develops_from UBERON:0003890 ! Mullerian duct intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: develops_from UBERON:0003890 ! Mullerian duct relationship: part_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0013398 name: choroidal gland is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004859 ! eye gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001776 ! optic choroid relationship: part_of UBERON:0001776 ! optic choroid [Term] id: UBERON:0013478 name: cecal tonsil def: "A thickened round patch of lymphoid tissue located at the ileocecal junction adjacent to the sacculus rotundus." [] synonym: "caecal tonsil" EXACT [] synonym: "cecal GALT" RELATED [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0000314 ! cecum mucosa relationship: part_of UBERON:0001153 ! caecum [Term] id: UBERON:0013479 name: lung endothelium def: "A blood vessel endothelium that is part of a lung [Automatically generated definition]." [] synonym: "respiratory endothelium" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0004638 ! blood vessel endothelium intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0013481 name: crypt of Lieberkuhn of ileum def: "An intestinal crypt that is located in the ileum." [] synonym: "ileal crypt" EXACT [] synonym: "ileal crypt of Lieberkuhn" EXACT [] synonym: "ileal intestinal crypt" EXACT [] is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0008344 ! intestinal villus of ileum [Term] id: UBERON:0013482 name: crypt of Lieberkuhn of duodenum def: "An intestinal crypt that is located in the duodenum." [] synonym: "duodenal crypt" EXACT [] synonym: "duodenal crypt of Lieberkuhn" EXACT [] is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008342 ! intestinal villus of duodenum [Term] id: UBERON:0013483 name: crypt of Lieberkuhn of jejunum def: "An intestinal crypt that is located in the jejunum." [] synonym: "jejunal crypt" EXACT [] synonym: "jejunal crypt of Lieberkuhn" EXACT [] is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0008343 ! intestinal villus of jejunum [Term] id: UBERON:0013485 name: crypt of Lieberkuhn of colon def: "An intestinal crypt that is located in the colon. The colonic crypts of Lieberkhn are straight and unbranched and lined largely with goblet cells." [] synonym: "colonic crypt" EXACT [] synonym: "colonic crypt of lieberkuhn" EXACT [] is_a: UBERON:0001984 ! crypt of lieberkuhn of large intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0000317 ! colonic mucosa relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0013486 name: crypt of Lieberkuhn of appendix def: "An intestinal crypt that is located in the appendix." [] synonym: "appendiceal crypt" EXACT [] synonym: "appendiceal crypt of lieberkuhn" EXACT [] is_a: UBERON:0013485 ! crypt of Lieberkuhn of colon intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0004989 ! mucosa of appendix [Term] id: UBERON:0013501 name: cloacal sphincter synonym: "sphincter cloacae" EXACT [] is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0014783 ! cloacal muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0013515 name: subdivision of uterine tube synonym: "subdivision of fallopian tube" RELATED [] synonym: "subdivision of oviduct" EXACT [] synonym: "uterine tube zone" EXACT [] synonym: "zone of uterine tube" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube is_a: UBERON:0014404 ! female anatomical structure relationship: part_of UBERON:0000993 ! oviduct [Term] id: UBERON:0013522 name: subdivision of tube is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0000025 ! tube [Term] id: UBERON:0013526 name: otocyst lumen synonym: "lumen of otocyst" EXACT [] is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0007473 ! lumen of epithelial sac intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: part_of UBERON:0003051 ! ear vesicle relationship: develops_from UBERON:0006273 ! otic pit relationship: part_of UBERON:0003051 ! ear vesicle [Term] id: UBERON:0013636 name: epithelium of intestinal villus synonym: "intestinal villus epithelium" EXACT [] synonym: "villous epithelium" RELATED [] synonym: "villus epithelium" RELATED [] is_a: UBERON:0001902 ! epithelium of small intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: UBERON:0013685 name: foramen of skull def: "Anatomical space that is an opening in a bone of the skull." [] synonym: "cranial conduit" EXACT [] synonym: "cranial foramen" EXACT [] synonym: "foramen of skull" RELATED [] synonym: "foramina of the skull" RELATED [] is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0005744 ! bone foramen intersection_of: part_of UBERON:0003129 ! skull relationship: part_of UBERON:0003129 ! skull [Term] id: UBERON:0013689 name: appendix lymphoid tissue def: "Lymphoid tissue located in the appendix." [] synonym: "appendix lymphoid" RELATED [] synonym: "lymphatic tissue of appendix" EXACT [] synonym: "lymphatic tissue of vermiform appendix" EXACT [] is_a: UBERON:0001744 ! lymphoid tissue intersection_of: UBERON:0001744 ! lymphoid tissue intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: UBERON:0013694 name: brain endothelium def: "Vascular endothelium found in blood vessels of the blood-brain-barrier." [] synonym: "cerebromicrovascular endothelium" RELATED [] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0013695 name: colon endothelium def: "Vascular endothelium found in colon blood vessels." [] synonym: "colon endothelial cell" RELATED [] synonym: "colon endothelial cells" RELATED [] synonym: "colonic endothelial cell" RELATED [] synonym: "colonic endothelium" RELATED [] synonym: "colorectal endothelial cell" RELATED [] synonym: "colorectal endothelium" RELATED [] is_a: UBERON:0000397 ! colonic epithelium is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: UBERON:0013696 name: tonsil epithelium def: "The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule." [] synonym: "epithelium of tonsil" RELATED [] synonym: "tonsil epithelial cell" RELATED [] is_a: UBERON:0003351 ! pharyngeal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0013697 name: exocrine pancreas epithelium def: "Epithelium lining the exocrine pancreas." [] synonym: "epithelium of exocrine pancreas" RELATED [] synonym: "exocrine pancreas epithelial cell" RELATED [] is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: UBERON:0013700 name: axial musculature def: "Musculature of the head and neck, spine, and ribs." [] is_a: UBERON:0001015 ! musculature relationship: part_of UBERON:0013701 ! main body axis [Term] id: UBERON:0013701 name: main body axis def: "A principle subdivision of an organism that includes all structures along the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." [] is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0013702 name: body proper def: "The region of the organism associated with the visceral organs." [] synonym: "body" RELATED [] synonym: "whole body" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0013701 ! main body axis [Term] id: UBERON:0013754 name: layer of skin synonym: "skin layer" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0002097 ! skin of body [Term] id: UBERON:0013755 name: arterial blood synonym: "arterial blood" EXACT [] synonym: "blood in artery" EXACT [] synonym: "portion of arterial blood" EXACT [] is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0013756 name: venous blood synonym: "blood in vein" EXACT [] synonym: "portion of venous blood" EXACT [] synonym: "venous blood" EXACT [] is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein [Term] id: UBERON:0013757 name: capillary blood synonym: "blood in capillary" EXACT [] synonym: "portion of blood in capillary" EXACT [] synonym: "portion of capillary blood" EXACT [] is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: part_of UBERON:0001982 ! capillary relationship: part_of UBERON:0001982 ! capillary [Term] id: UBERON:0013765 name: digestive system organ synonym: "digestive organ" EXACT [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0013768 name: great vessel of heart def: "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." [] synonym: "great vessel" BROAD [] synonym: "great vessel of thorax" EXACT [] is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0014371 name: future telencephalon def: "Embryonic structure that gives rise to the telencephalon." [] synonym: "presumptive telencephalon" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0006240 ! future forebrain [Term] id: UBERON:0014387 name: mesenchyme derived from neural crest def: "Mesenchyme that develops_from the neural crest[Automatically generated definition]." [] synonym: "mesenchyme from neural crest" EXACT [] synonym: "neural crest derived mesenchyme" EXACT [] synonym: "neural crest mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0002342 ! neural crest relationship: develops_from UBERON:0002342 ! neural crest [Term] id: UBERON:0014388 name: kidney collecting duct epithelium def: "The simple cuboidal epithelium lining the lumen of kidney collecting ducts." [] synonym: "collecting duct of renal tubule epithelium" EXACT [] synonym: "epithelium of collecting duct of renal tubule" EXACT [] synonym: "epithelium of renal collecting tubule" EXACT [] is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0004211 ! nephron epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: UBERON:0014390 name: muscle layer of ileum synonym: "ileal smooth muscle" RELATED [] synonym: "muscularis externa of ileum" EXACT [] synonym: "muscularis propria of ileum" RELATED [] synonym: "smooth muscle of ileum" RELATED [] is_a: UBERON:0011201 ! muscle layer of small intestine intersection_of: UBERON:0006660 ! muscle layer intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: UBERON:0014401 name: renal venous blood vessel def: "any member of the network of tubes that return blood from the renal tissues to the systemic circulation." [] synonym: "kidney venous blood vessel" EXACT [] synonym: "venous blood vessel of kidney" EXACT [] is_a: UBERON:0003517 ! kidney blood vessel is_a: UBERON:0003920 ! venous blood vessel intersection_of: UBERON:0003920 ! venous blood vessel intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: UBERON:0014402 name: sex-specific anatomical structure def: "A part of the body present only in a specific gender." [] synonym: "gender-specific" EXACT [] synonym: "gender-specific anatomical structure" EXACT [] synonym: "sex-specific" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0014403 name: male anatomical structure def: "A part of the body present only in males." [] synonym: "male-specific" EXACT [] is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: part_of UBERON:0003101 ! male organism relationship: part_of UBERON:0003101 ! male organism [Term] id: UBERON:0014404 name: female anatomical structure def: "A part of the body present only in females." [] is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0003100 ! female organism [Term] id: UBERON:0014452 name: gustatory epithelium of tongue synonym: "lingual gustatory epithelium" EXACT [] is_a: UBERON:0002926 ! gustatory epithelium is_a: UBERON:0003357 ! epithelium of tongue intersection_of: UBERON:0002926 ! gustatory epithelium intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0014455 name: subcutaneous abdominal adipose tissue def: "Subcutaneous adipose tissue that is located in the abdominal region." [] synonym: "abdominal subcutaneous adipose tissue" EXACT [] synonym: "subcutaneous abdominal fat" EXACT [] synonym: "subcutaneous fat of abdominal region" EXACT [] is_a: UBERON:0002190 ! subcutaneous adipose tissue is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0000916 ! abdomen intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0002072 ! hypodermis [Term] id: UBERON:0014699 name: extraembryonic venous system is_a: UBERON:0004582 ! venous system is_a: UBERON:0014701 ! extraembryonic vascular system intersection_of: UBERON:0004582 ! venous system intersection_of: part_of UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0002331 ! umbilical cord [Term] id: UBERON:0014701 name: extraembryonic vascular system is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007798 ! vascular system intersection_of: UBERON:0007798 ! vascular system intersection_of: part_of UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0002331 ! umbilical cord [Term] id: UBERON:0014702 name: frontonasal process epithelium is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0004066 ! frontonasal prominence relationship: develops_from UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0004066 ! frontonasal prominence [Term] id: UBERON:0014703 name: anal membrane ectodermal component is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0001353 ! anal region relationship: develops_from UBERON:0000924 ! ectoderm relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0014706 name: primitive renal collecting duct system synonym: "metanephros primitive collecting ducts" EXACT [] synonym: "primitive collecting duct" EXACT [] is_a: UBERON:0007501 ! arborizing epithelial duct system is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0000084 ! ureteric bud [Term] id: UBERON:0014717 name: mucous acinus def: "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." [] synonym: "acinus of mucuous gland" EXACT [] synonym: "mucus acinus" EXACT [] is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! acinus intersection_of: part_of UBERON:0000414 ! mucous gland relationship: part_of UBERON:0000414 ! mucous gland [Term] id: UBERON:0014719 name: intralobular duct def: "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular" [] synonym: "intralobular ductule" RELATED [] is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0009911 ! lobule relationship: part_of UBERON:0009911 ! lobule [Term] id: UBERON:0014775 name: prosomere def: "A neuromere that is part of the presumptive forebrain" [] synonym: "forebrain segment" BROAD [] synonym: "future prosencephalon" RELATED [] synonym: "segment of forebrain" BROAD [] is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: part_of UBERON:0006240 ! future forebrain relationship: part_of UBERON:0006240 ! future forebrain [Term] id: UBERON:0014776 name: mesomere def: "A neuromere that is part of the presumptive midbrain" [] synonym: "future mesencephalon" RELATED [] synonym: "midbrain segment" BROAD [] synonym: "segment of midbrain" BROAD [] is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: part_of UBERON:0009616 ! presumptive midbrain relationship: part_of UBERON:0009616 ! presumptive midbrain [Term] id: UBERON:0014783 name: cloacal muscle is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013765 ! digestive system organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca [Term] id: UBERON:0014790 name: lingual septum def: "The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ." [] synonym: "median fibrous septum" RELATED [] synonym: "septum of tongue" EXACT [] synonym: "septum of tongue" RELATED [] synonym: "tongue septum" RELATED [] is_a: UBERON:0003037 ! septum is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003037 ! septum intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue [Term] id: UBERON:0014892 name: skeletal muscle organ def: "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." [] synonym: "skeletal muscle" BROAD [] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from UBERON:0003082 ! myotome [Term] id: UBERON:0014903 name: primordial vasculature def: "A portion of tissue that will develop into vasculature." [] is_a: UBERON:0001048 ! primordium relationship: part_of UBERON:0011695 ! embryonic cardiovascular system [Term] id: UBERON:0014907 name: intersomitic vessel def: "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." [] synonym: "intersegmental vessel" EXACT [] synonym: "intersegmental vessels" EXACT [] synonym: "intersomitic vessels" EXACT [] synonym: "segmental vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel relationship: develops_from UBERON:0005805 ! dorsal aorta [Term] id: UBERON:0015005 name: vertebra endochondral element def: "A vertebra bone or its cartilage or pre-cartilage precursor." [] synonym: "vertebra element" EXACT [] synonym: "vertebra skeletal element" BROAD [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0002412 ! vertebra union_of: UBERON:0011094 ! vertebra cartilage element union_of: UBERON:0011095 ! vertebra pre-cartilage condensation relationship: part_of UBERON:0001130 ! vertebral column [Term] id: UBERON:1000023 name: spleen pulp def: "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." [] synonym: "malpighian corpuscles" EXACT [] synonym: "pulp of spleen" EXACT [] synonym: "splenic pulp" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:1000024 ! parenchyma of spleen [Term] id: UBERON:1000024 name: parenchyma of spleen def: "A parenchyma that is part of a spleen." [] synonym: "splenic parenchyma" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:2000120 name: lateral line ganglion def: "Ganglion that develops from a cranial ectodermal placode and contains sensory neurons that innervate a lateral line." [] synonym: "lateral line ganglia" EXACT [] synonym: "LLG" EXACT [] is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: part_of UBERON:0002540 ! lateral line system relationship: part_of UBERON:0002540 ! lateral line system [Term] id: UBERON:2000175 name: posterior lateral line nerve def: "Cranial nerve which enters the brain between cranial nerves VIII and IX; contains afferents and sensory efferents to the posterior lateral line ganglion and middle ganglion. Fibers from the posterior lateral line ganglion innervate the occipital dorsal lateral line and trunk lateral lines." [] synonym: "caudal lateral line nerve" EXACT [] is_a: UBERON:0008906 ! lateral line nerve relationship: part_of UBERON:2001471 ! posterior lateral line system [Term] id: UBERON:2000228 name: lateral line primordium synonym: "lateral line primordia" EXACT [] synonym: "llp" EXACT [] is_a: UBERON:0000479 ! tissue relationship: part_of UBERON:0002540 ! lateral line system [Term] id: UBERON:2000425 name: anterior lateral line nerve def: "Cranial nerve which enters the brain between cranial nerves VI and VII; contains afferents and sensory efferents to the anterior lateral line ganglia." [] synonym: "rostral lateral line nerve" EXACT [] is_a: UBERON:0008906 ! lateral line nerve relationship: part_of UBERON:2001468 ! anterior lateral line system [Term] id: UBERON:2001156 name: posterior lateral line placode is_a: UBERON:0003067 ! dorsolateral placode relationship: part_of UBERON:2001471 ! posterior lateral line system [Term] id: UBERON:2001314 name: posterior lateral line ganglion def: "The posterior lateral line ganglion develops from a cranial ectodermal placode and contains sensory neurons that innervate the posterior lateral line system." [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:2000120 ! lateral line ganglion relationship: develops_from UBERON:2001156 ! posterior lateral line placode [Term] id: UBERON:2001316 name: anterior lateral line placode def: "Dorsolateral placode that gives rise to the anterior lateral line." [] synonym: "anterior lateral line placodes" RELATED [] synonym: "pre-auditory lateral line placode" RELATED [] is_a: UBERON:0003067 ! dorsolateral placode intersection_of: UBERON:0003067 ! dorsolateral placode intersection_of: part_of UBERON:2001468 ! anterior lateral line system relationship: part_of UBERON:2001468 ! anterior lateral line system [Term] id: UBERON:2001391 name: anterior lateral line ganglion def: "The anteror lateral line ganglia develops from cranial ectodermal placodes and contain sensory neurons that innervate the anterior lateral line system." [] synonym: "anterior lateral line ganglia" RELATED [] is_a: UBERON:2000120 ! lateral line ganglion intersection_of: UBERON:2000120 ! lateral line ganglion intersection_of: part_of UBERON:2001468 ! anterior lateral line system relationship: part_of UBERON:2001468 ! anterior lateral line system [Term] id: UBERON:2001468 name: anterior lateral line system def: "The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [] is_a: UBERON:0002540 ! lateral line system [Term] id: UBERON:2001470 name: anterior lateral line def: "The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [] is_a: UBERON:0010202 ! lateral line intersection_of: UBERON:0010202 ! lateral line intersection_of: part_of UBERON:2001468 ! anterior lateral line system relationship: develops_from UBERON:2005117 ! anterior lateral line primordium relationship: part_of UBERON:2001468 ! anterior lateral line system [Term] id: UBERON:2001471 name: posterior lateral line system def: "The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [] is_a: UBERON:0002540 ! lateral line system [Term] id: UBERON:2005117 name: anterior lateral line primordium def: "A migrating group of cells originating from an anterior lateral line placode. The primordium deposits neuromasts and interneuromasts between them during its migration." [] synonym: "anterior lateral line primordia" EXACT [] is_a: UBERON:2000228 ! lateral line primordium relationship: part_of UBERON:2001468 ! anterior lateral line system [Term] id: UBERON:2005260 name: fenestrated capillary def: "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse" [] synonym: "fenestrated blood vessel endothelium" BROAD [] synonym: "fenestrated capillary vessel" EXACT [] is_a: UBERON:0001982 ! capillary is_a: UBERON:0004638 ! blood vessel endothelium [Term] id: http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 name: alobate nucleus is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0002506 ! alobate relationship: bearer_of PATO:0002506 ! alobate [Typedef] id: RO:0002120 name: synapsed to [Typedef] id: RO:0002130 name: has synaptic terminal in [Typedef] id: RO:0002131 name: overlaps xref: RO:0002131 [Typedef] id: RO:0002203 name: develops into is_transitive: true inverse_of: develops_from ! develops_from [Typedef] id: RO:0002215 name: capable_of def: "A relation between a material entity (such as a cell) and a process. This is a shortcut relation, translation rule for which is: capable_of P <-> bearer_of (some realized_by only P). Example: osteoclast capable of bone resorption." [GOC:cjm] expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000053 some (http://purl.obolibrary.org/obo/BFO_0000054 only ?Y)" [] [Typedef] id: RO:0002220 name: adjacent_to [Typedef] id: bearer_of name: bearer of [Typedef] id: develops_from name: develops_from xref: RO:0002202 holds_over_chain: part_of develops_from is_transitive: true transitive_over: part_of ! part_of [Typedef] id: has_completed name: has_completed [Typedef] id: has_high_plasma_membrane_amount name: has_high_plasma_membrane_amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] is_a: has_plasma_membrane_part ! has_plasma_membrane_part [Typedef] id: has_low_plasma_membrane_amount name: has_low_plasma_membrane_amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] is_a: has_plasma_membrane_part ! has_plasma_membrane_part [Typedef] id: has_not_completed name: has_not_completed [Typedef] id: has_part name: has_part is_transitive: true [Typedef] id: has_plasma_membrane_part name: has_plasma_membrane_part def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." [PMID:19243617] is_a: has_part ! has_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] [Typedef] id: has_relational_adjective name: has_relational_adjective namespace: uberon comment: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. xref: UBPROP:0000007 is_metadata_tag: true [Typedef] id: immediate_transformation_of name: immediate_transformation_of synonym: "direct_transformation_of" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "immediately transforms from" EXACT [SIO:000658] xref: http://semanticscience.org/resource/SIO_000658 property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl [Typedef] id: lacks_part name: lacks_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y" [] [Typedef] id: lacks_plasma_membrane_part name: lacks_plasma_membrane_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] [Typedef] id: located_in name: located_in [Typedef] id: negatively_regulates name: negatively_regulates is_a: regulates ! regulates [Typedef] id: occurs_in name: occurs in transitive_over: part_of ! part_of [Typedef] id: part_of name: part_of is_transitive: true inverse_of: has_part ! has_part [Typedef] id: participates_in name: participates in [Typedef] id: positively_regulates name: positively_regulates is_a: regulates ! regulates [Typedef] id: produces name: produces [Typedef] id: realized_by name: realized by [Typedef] id: regulates name: regulates property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl transitive_over: part_of ! part_of [Typedef] id: secretes name: secretes [Typedef] id: seeAlso name: see also namespace: uberon xref: http://www.w3.org/2000/01/rdf-schema#seeAlso is_metadata_tag: true