format-version: 1.2 data-version: releases/2015-06-17 subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis" synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens" synonymtypedef: LATIN "latin term" synonymtypedef: PLURAL "plural term" remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 10 Logical Axioms: 3] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 3137 Logical Axioms: 1427] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 75 Logical Axioms: 29] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 177 Logical Axioms: 62] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 3206 Logical Axioms: 255] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 1503 Logical Axioms: 347] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 41 Logical Axioms: 13] remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 6818 Logical Axioms: 1463] remark: See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo. ontology: cl owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nEquivalentClasses( ObjectSomeValuesFrom( ))\nEquivalentClasses( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) ))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nEquivalentClasses( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) ))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ))\nSubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nEquivalentClasses( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) ))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nSubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nEquivalentClasses(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nSubClassOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\nEquivalentClasses(ObjectSomeValuesFrom( ) ObjectComplementOf(ObjectSomeValuesFrom( )))\nSubClassOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))\n) [Term] id: BFO:0000002 name: continuant [Term] id: BFO:0000003 name: occurrent [Term] id: BFO:0000004 name: independent continuant is_a: BFO:0000002 ! continuant [Term] id: BFO:0000015 name: process is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000017 name: realizable entity is_a: BFO:0000020 ! specifically dependent continuant [Term] id: BFO:0000020 name: specifically dependent continuant is_a: BFO:0000002 ! continuant [Term] id: CARO:0000003 name: anatomical structure is_a: CARO:0000006 ! material anatomical entity [Term] id: CARO:0000006 name: material anatomical entity [Term] id: CARO:0000014 name: cell part is_a: CARO:0000003 ! anatomical structure [Term] id: CHEBI:23367 name: molecular entity is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:24431 name: chemical entity [Term] id: CHEBI:24651 name: hydroxides is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25179 name: melanin is_a: CHEBI:26195 ! polyphenol [Term] id: CHEBI:25367 name: molecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25806 name: oxygen molecular entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:26195 name: polyphenol is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:33304 name: chalcogen molecular entity is_a: CHEBI:33675 ! p-block molecular entity [Term] id: CHEBI:33579 name: main group molecular entity is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33582 name: carbon group molecular entity is_a: CHEBI:33675 ! p-block molecular entity [Term] id: CHEBI:33595 name: cyclic compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33608 name: hydrogen molecular entity is_a: CHEBI:33674 ! s-block molecular entity [Term] id: CHEBI:33655 name: aromatic compound is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33659 name: organic aromatic compound is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33674 name: s-block molecular entity is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:33675 name: p-block molecular entity is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:33822 name: organic hydroxy compound is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33832 name: organic cyclic compound is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33853 name: phenols is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:36357 name: polyatomic entity is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:37577 name: heteroatomic molecular entity is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:50860 name: organic molecular entity is_a: CHEBI:33582 ! carbon group molecular entity [Term] id: CHEBI:72695 name: organic molecule is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CL:0000000 name: cell namespace: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: CARO:0000003 ! anatomical structure is_a: GO:0005575 ! cellular_component equivalent_to: GO:0005623 ! cell [Term] id: CL:0000001 name: primary cultured cell namespace: cell def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." [ReO:mhb] comment: Covers cells actively being cultured or stored in a quiescent state for future use. synonym: "primary cell culture cell" EXACT [] synonym: "primary cell line cell" RELATED [] synonym: "unpassaged cultured cell" EXACT [] xref: BTO:0002290 is_a: CL:0000010 ! cultured cell [Term] id: CL:0000002 name: obsolete immortal cell line cell namespace: cell def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "continuous cell line cell" EXACT [] synonym: "permanent cell line cell" EXACT [] is_obsolete: true replaced_by: CLO:0000019 [Term] id: CL:0000003 name: native cell namespace: cell def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah] comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). subset: ubprop:upper_level synonym: "cell in vivo" NARROW [] xref: CARO:0000013 is_a: CL:0000000 ! cell is_a: GO:0005623 ! cell [Term] id: CL:0000004 name: obsolete cell by organism namespace: cell def: "OBSOLETE: A classification of cells by the organisms within which they are contained." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000005 name: fibroblast neural crest derived namespace: cell is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell namespace: cell synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! receptor cell intersection_of: CL:0000197 ! receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell namespace: cell def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000008 name: migratory cranial neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000009 name: obsolete fusiform initial namespace: cell alt_id: CL:0000274 def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208] comment: replaced_by: PO:0000079 synonym: "xylem initial" RELATED [] synonym: "xylem mother cell" RELATED [] is_obsolete: true [Term] id: CL:0000010 name: cultured cell namespace: cell def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [ReO:mhb] comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000011 name: migratory trunk neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000012 name: obsolete cell by class namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000013 name: obsolete dentine secreting cell namespace: cell is_obsolete: true consider: CL:0000140 [Term] id: CL:0000014 name: germ line stem cell namespace: cell synonym: "germline stem cell" EXACT [] is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0000039 {is_inferred="true"} ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000015 name: male germ cell namespace: cell xref: FMA:72290 xref: MA:0002765 xref: ncithesaurus:Spermatogenic_Cell xref: VHOG:0001531 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0007283 ! spermatogenesis relationship: capable_of GO:0007283 ! spermatogenesis [Term] id: CL:0000016 name: male germ line stem cell namespace: cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte namespace: cell def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A05.360.490.890.880] xref: BTO:0001275 xref: CALOHA:TS-0951 xref: EMAPA:31484 xref: FBbt:00004936 xref: FMA:84049 xref: WBbt:0006799 is_a: CL:0000015 {is_inferred="true"} ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: capable_of GO:0048137 ! spermatocyte division relationship: capable_of GO:0048137 ! spermatocyte division relationship: develops_from CL:0000020 ! spermatogonium [Term] id: CL:0000018 name: spermatid namespace: cell def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A05.360.490.890.860] synonym: "nematoblast" EXACT [] xref: BTO:0001274 xref: CALOHA:TS-0950 xref: EMAPA:31486 xref: FBbt:00004942 xref: FMA:72294 xref: WBbt:0006800 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000413 ! haploid cell intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: capable_of GO:0001675 ! acrosome assembly intersection_of: capable_of GO:0007288 ! sperm axoneme assembly intersection_of: capable_of GO:0007289 ! spermatid nucleus differentiation relationship: bearer_of PATO:0001375 ! haploid relationship: capable_of GO:0001675 ! acrosome assembly relationship: capable_of GO:0007288 ! sperm axoneme assembly relationship: capable_of GO:0007289 ! spermatid nucleus differentiation relationship: develops_from CL:0000657 ! secondary spermatocyte [Term] id: CL:0000019 name: sperm namespace: cell def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A05.360.490.890] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] xref: BTO:0001277 xref: BTO:0002046 xref: CALOHA:TS-0949 xref: FBbt:00004954 xref: FMA:67338 xref: WBbt:0006798 is_a: CL:0000064 ! ciliated cell is_a: CL:0000219 ! motile cell is_a: CL:0000408 {is_inferred="true"} ! male gamete intersection_of: CL:0000408 ! male gamete intersection_of: capable_of GO:0030317 ! sperm motility intersection_of: capable_of GO:0048240 ! sperm capacitation relationship: capable_of GO:0030317 ! sperm motility relationship: capable_of GO:0048240 ! sperm capacitation relationship: develops_from CL:0000018 ! spermatid relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000020 name: spermatogonium namespace: cell def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A05.360.490.890.900] xref: BTO:0000958 xref: CALOHA:TS-2193 xref: EMAPA:31482 xref: FBbt:00004935 xref: FMA:72291 is_a: CL:0000015 ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001394 ! diploid intersection_of: bearer_of PATO:0001501 ! immature relationship: bearer_of PATO:0001394 ! diploid relationship: bearer_of PATO:0001501 ! immature [Term] id: CL:0000021 name: female germ cell namespace: cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0048477 ! oogenesis relationship: capable_of GO:0048477 ! oogenesis [Term] id: CL:0000022 name: female germ line stem cell namespace: cell is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000023 name: oocyte namespace: cell def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FBbt:00004886 xref: FMA:18644 xref: WBbt:0006797 is_a: CL:0000021 {is_inferred="true"} ! female germ cell relationship: participates_in GO:0007143 ! female meiotic division [Term] id: CL:0000024 name: oogonial cell namespace: cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] xref: FMA:83673 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0007067 ! mitotic nuclear division relationship: capable_of GO:0007067 ! mitotic nuclear division relationship: develops_from CL:0000670 ! primordial germ cell [Term] id: CL:0000025 name: egg cell namespace: cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FBbt:00057012 xref: FMA:67343 xref: MA:0000388 is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: develops_from CL:0000023 ! oocyte relationship: participates_in GO:0007143 ! female meiotic division [Term] id: CL:0000026 name: invertebrate nurse cell namespace: cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391] synonym: "nurse cell" RELATED [] xref: BTO:0000953 xref: FBbt:00004878 is_a: CL:0000039 ! germ line cell is_a: CL:0000412 ! polyploid cell relationship: develops_from CL:0000722 ! cystoblast [Term] id: CL:0000027 name: smooth muscle cell neural crest derived namespace: cell is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000028 name: CNS neuron (sensu Nematoda and Protostomia) namespace: cell is_a: CL:2000029 ! central nervous system neuron relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000029 name: neuron neural crest derived namespace: cell is_a: CL:0000540 {is_inferred="true"} ! neuron intersection_of: CL:0000540 ! neuron intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000030 name: glioblast namespace: cell xref: FBbt:00005145 is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000031 name: neuroblast namespace: cell def: "A cell that will develop into a neuron often after a migration phase." [http://en.wikipedia.org/wiki/Neuroblast] {editor="GOC:NV"} xref: BTO:0000930 xref: FBbt:00005146 xref: FMA:70563 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000032 name: neuroplacodal cell namespace: cell def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256] synonym: "neural placode cell" EXACT [] is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000033 name: apocrine cell namespace: cell def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000034 name: stem cell namespace: cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A11.872] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0011115 ! precursor cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0030154 ! cell differentiation [Term] id: CL:0000035 name: single fate stem cell namespace: cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001400 ! unipotent intersection_of: capable_of GO:0017145 ! stem cell division relationship: bearer_of PATO:0001400 ! unipotent relationship: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000036 name: epithelial fate stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000037 name: hematopoietic stem cell namespace: cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 xref: FMA:86475 xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: capable_of GO:0048103 ! somatic stem cell division intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation relationship: capable_of GO:0048103 ! somatic stem cell division relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000038 name: erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell namespace: cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: ubprop:upper_level is_a: CL:0000548 ! animal cell disjoint_from: CL:0002371 ! somatic cell relationship: capable_of GO:0022414 ! reproductive process [Term] id: CL:0000040 name: monoblast namespace: cell def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. synonym: "CFU-M" RELATED [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: CALOHA:TS-1195 xref: FMA:83553 is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: capable_of GO:0030224 ! monocyte differentiation intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part GO:0000791 ! euchromatin intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: capable_of GO:0030224 ! monocyte differentiation relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part GO:0000791 ! euchromatin relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000041 name: mature eosinophil namespace: cell def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000771 ! eosinophil intersection_of: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II intersection_of: capable_of GO:0002540 ! leukotriene production involved in inflammatory response intersection_of: capable_of GO:0045730 ! respiratory burst intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: has_part PR:000007152 ! eosinophil peroxidase intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_part PR:000014046 ! non-secretory ribonuclease intersection_of: has_part PR:000014047 ! eosinophil cationic protein intersection_of: has_part PR:000022006 ! eosinophil granule major basic protein intersection_of: has_plasma_membrane_part PR:000009129 ! integrin alpha-4 relationship: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: capable_of GO:0002540 ! leukotriene production involved in inflammatory response relationship: capable_of GO:0045730 ! respiratory burst relationship: develops_from CL:0000774 ! band form eosinophil relationship: has_part CP:0000025 ! lobed nucleus relationship: has_part PR:000007152 ! eosinophil peroxidase relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_part PR:000014046 ! non-secretory ribonuclease relationship: has_part PR:000014047 ! eosinophil cationic protein relationship: has_part PR:000022006 ! eosinophil granule major basic protein relationship: has_plasma_membrane_part PR:000009129 ! integrin alpha-4 [Term] id: CL:0000042 name: neutrophilic myeloblast namespace: cell def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [GOC:add, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic granuloblast" RELATED [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: capable_of GO:0030223 ! neutrophil differentiation intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000010799 ! myb proto-oncogene protein intersection_of: has_part PR:000014362 ! runt-related transcription factor 1 relationship: capable_of GO:0030223 ! neutrophil differentiation relationship: develops_from CL:0000834 ! neutrophil progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000010799 ! myb proto-oncogene protein relationship: has_part PR:000014362 ! runt-related transcription factor 1 [Term] id: CL:0000043 name: mature basophil namespace: cell alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002242 ! nucleate cell is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000767 ! basophil intersection_of: capable_of GO:0002349 ! histamine production involved in inflammatory response intersection_of: capable_of GO:0002351 ! serotonin production involved in inflammatory response intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response intersection_of: capable_of GO:0008015 ! blood circulation intersection_of: capable_of GO:0032616 ! interleukin-13 production intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: capable_of GO:0048295 ! positive regulation of isotype switching to IgE isotypes intersection_of: has_part CP:0000025 ! lobed nucleus relationship: capable_of GO:0002349 ! histamine production involved in inflammatory response relationship: capable_of GO:0002351 ! serotonin production involved in inflammatory response relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response relationship: capable_of GO:0008015 ! blood circulation relationship: capable_of GO:0032616 ! interleukin-13 production relationship: capable_of GO:0032633 ! interleukin-4 production relationship: capable_of GO:0048295 ! positive regulation of isotype switching to IgE isotypes relationship: develops_from CL:0000770 ! band form basophil relationship: has_part CP:0000025 ! lobed nucleus [Term] id: CL:0000045 name: obsolete thymus processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. is_obsolete: true [Term] id: CL:0000046 name: obsolete bursa processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead. is_obsolete: true [Term] id: CL:0000047 name: neuronal stem cell namespace: cell def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [GOC:tfm, http://en.wikipedia.org/wiki/Neural_stem_cell, MESH:D058953, PMID:15247488] synonym: "neural stem cell" EXACT [] synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000048 name: multi fate stem cell namespace: cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000034 ! stem cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: bearer_of PATO:0001402 ! multipotent intersection_of: capable_of GO:0017145 ! stem cell division relationship: bearer_of PATO:0001402 ! multipotent relationship: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000049 name: common myeloid progenitor namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). synonym: "CFU-GEMM" RELATED [ISBN:0878932437] synonym: "CFU-S" RELATED [ISBN:0878932437] synonym: "CMP" EXACT [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: capable_of GO:0030219 ! megakaryocyte differentiation relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000051 name: common lymphoid progenitor namespace: cell alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. synonym: "CLP" EXACT [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030098 ! lymphocyte differentiation relationship: capable_of GO:0030098 ! lymphocyte differentiation [Term] id: CL:0000052 name: totipotent stem cell namespace: cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000054 name: bone matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000055 name: non-terminally differentiated cell namespace: cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: define using PATO mulit-potent or oligopotent? synonym: "blast cell" EXACT [] xref: BTO:0000125 xref: FMA:84782 is_a: CL:0011115 ! precursor cell relationship: capable_of GO:0030154 ! cell differentiation [Term] id: CL:0000056 name: myoblast namespace: cell def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:A11.635, PMID:21849021] xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FBbt:00005083 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast namespace: cell def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:A11.329.228, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: VHOG:0001482 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000058 name: chondroblast namespace: cell def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007009 ! prechondroblast relationship: produces UBERON:0002418 ! cartilage tissue [Term] id: CL:0000059 name: ameloblast namespace: cell alt_id: CL:0000053 alt_id: CL:0000139 def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:A11.436.107] comment: non-encoded relationship from VSAO produces VSAO:0000066 synonym: "amelocyte" EXACT [] synonym: "enamel secreting cell" EXACT [] xref: BTO:0001663 xref: FMA:70576 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0000151 ! secretory cell relationship: adjacent_to UBERON:0001763 ! odontogenic papilla relationship: capable_of GO:0097186 ! amelogenesis relationship: develops_from CL:0007000 ! preameloblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001752 ! enamel [Term] id: CL:0000060 name: odontoblast namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256] comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. xref: BTO:0001769 xref: CALOHA:TS-0696 xref: FMA:62999 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002159 ! general ecto-epithelial cell relationship: develops_from CL:0007003 ! preodontoblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000061 name: cementoblast namespace: cell alt_id: CL:0000859 def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [GO_REF:0000034, ISBN:0781733901] comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth. synonym: "cementum secreting cell" EXACT [] xref: CALOHA:TS-1164 xref: FMA:63002 is_a: CL:0000062 ! osteoblast is_a: CL:0000151 ! secretory cell relationship: develops_from CL:0007002 ! precementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001753 ! cementum [Term] id: CL:0000062 name: osteoblast namespace: cell def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:A11.329.629] comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 xref: BTO:0001593 xref: CALOHA:TS-0720 xref: FMA:66780 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007010 ! preosteoblast relationship: produces UBERON:0008883 ! osteoid [Term] id: CL:0000063 name: obsolete cell by histology namespace: cell def: "OBSOLETE: A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000064 name: ciliated cell namespace: cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: has_plasma_membrane_part GO:0005929 ! cilium relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000065 name: ependymal cell namespace: cell def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134] synonym: "ependymocyte" EXACT [] xref: BTO:0001724 xref: FMA:70550 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000066 name: epithelial cell namespace: cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A11.436] synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FBbt:00000124 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000548 ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000483 ! epithelium disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium [Term] id: CL:0000067 name: ciliated epithelial cell namespace: cell def: "An epithelial cell that has a cillia." [GOC:tfm] xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: has_plasma_membrane_part GO:0005929 ! cilium relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000068 name: duct epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000058 ! duct relationship: part_of UBERON:0000058 ! duct [Term] id: CL:0000069 name: branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000070 name: obsolete epithelial cell of gland namespace: cell is_obsolete: true [Term] id: CL:0000071 name: blood vessel endothelial cell namespace: cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] synonym: "cuboidal endothelial cell of vascular tree" EXACT [] is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0004638 ! blood vessel endothelium relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell relationship: part_of UBERON:0004638 ! blood vessel endothelium [Term] id: CL:0000072 name: non-branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000073 name: barrier epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000074 name: obsolete epithem cell namespace: cell def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305] comment: replaced_by: PO:0000066 is_obsolete: true [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000076 name: squamous epithelial cell namespace: cell xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell namespace: cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000078 name: peridermal cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000079 name: stratified epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000357 ! stratified epithelial stem cell [Term] id: CL:0000080 name: circulating cell namespace: cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0000179 ! haemolymphatic fluid [Term] id: CL:0000081 name: blood cell namespace: cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] xref: FMA:62844 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0008015 ! blood circulation relationship: capable_of GO:0008015 ! blood circulation [Term] id: CL:0000082 name: epithelial cell of lung namespace: cell synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000115 ! lung epithelium relationship: part_of UBERON:0002048 ! lung [Term] id: CL:0000083 name: epithelial cell of pancreas namespace: cell def: "An epithelial cell of the pancreas." [GOC:tfm] synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0000223 ! endodermal cell relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000084 name: T cell namespace: cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: VHOG:0001479 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: capable_of GO:0002456 ! T cell mediated immunity disjoint_from: CL:0000623 ! natural killer cell disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: capable_of GO:0002456 ! T cell mediated immunity relationship: develops_from CL:0000827 ! pro-T cell [Term] id: CL:0000085 name: germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000086 name: germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004861 is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000087 name: male germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004929 is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000088 name: female germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004873 is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000089 name: male germ line stem cell (sensu Vertebrata) namespace: cell synonym: "spermatogonial stem cell" EXACT [PMID:19948499] is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000090 name: female germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000091 name: Kupffer cell namespace: cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A11.329.372.588, PMID:15771589, PMID:17105582] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] synonym: "liver macrophage" EXACT [] synonym: "macrophagocytus stellatus" EXACT [] synonym: "stellate cell of von Kupffer" EXACT [] synonym: "von Kupffer cell" EXACT [] xref: BTO:0000685 xref: FMA:14656 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: capable_of GO:0034102 ! erythrocyte clearance intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: RO:0001025 UBERON:0001281 ! hepatic sinusoid relationship: capable_of GO:0034102 ! erythrocyte clearance relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: RO:0001025 UBERON:0001281 ! hepatic sinusoid [Term] id: CL:0000092 name: osteoclast namespace: cell def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: capable_of GO:0045453 ! bone resorption intersection_of: has_part PR:000001850 ! cathepsin K intersection_of: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos intersection_of: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: part_of UBERON:0001474 ! bone element relationship: capable_of GO:0045453 ! bone resorption relationship: develops_from CL:0000576 ! monocyte relationship: has_part PR:000001850 ! cathepsin K relationship: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000007597 ! proto-oncogene c-Fos relationship: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit relationship: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: part_of UBERON:0001474 ! bone element [Term] id: CL:0000093 name: obsolete osteochondroclast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using 'osteoclast ; CL:0000092' instead. is_obsolete: true [Term] id: CL:0000094 name: granulocyte namespace: cell def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:A11.118.637.415, MESH:D006098] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: capable_of GO:0008015 ! blood circulation intersection_of: has_part GO:0030141 ! secretory granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8 intersection_of: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: capable_of GO:0008015 ! blood circulation relationship: has_part GO:0030141 ! secretory granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8 relationship: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000095 name: neuron associated cell namespace: cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000096 name: mature neutrophil namespace: cell def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [GOC:add, GOC:tfm, http://www.cap.org, MESH:A11.118.637.415.583, MESH:D009504, PMID:11138776, PMID:12560239, PMID:15514007, PMID:7880385] comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 is_a: CL:0000234 ! phagocyte is_a: CL:0000775 {is_inferred="true"} ! neutrophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000775 ! neutrophil intersection_of: capable_of GO:0002536 ! respiratory burst involved in inflammatory response intersection_of: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis intersection_of: capable_of GO:0006909 ! phagocytosis intersection_of: capable_of GO:0032637 ! interleukin-8 production intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001256 ! C-X-C chemokine receptor type 1 intersection_of: has_plasma_membrane_part PR:000001257 ! C-X-C chemokine receptor type 2 intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1 intersection_of: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: lacks_part PR:000010543 ! myeloperoxidase intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein relationship: capable_of GO:0002536 ! respiratory burst involved in inflammatory response relationship: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis relationship: capable_of GO:0006909 ! phagocytosis relationship: capable_of GO:0032637 ! interleukin-8 production relationship: develops_from CL:0000560 ! band form neutrophil relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part CP:0000025 ! lobed nucleus relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001256 ! C-X-C chemokine receptor type 1 relationship: has_plasma_membrane_part PR:000001257 ! C-X-C chemokine receptor type 2 relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1 relationship: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010543 ! myeloperoxidase relationship: lacks_part PR:000010799 ! myb proto-oncogene protein [Term] id: CL:0000097 name: mast cell namespace: cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [ISBN:0721601464] synonym: "mastocyte" EXACT [ISBN:0721601464] synonym: "tissue basophil" RELATED [ISBN:068340007X] xref: BTO:0000830 xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: capable_of GO:0002349 ! histamine production involved in inflammatory response intersection_of: capable_of GO:0002539 ! prostaglandin production involved in inflammatory response intersection_of: capable_of GO:0002660 ! positive regulation of peripheral tolerance induction intersection_of: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response intersection_of: capable_of GO:0030210 ! heparin biosynthetic process intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_part GO:0030141 ! secretory granule intersection_of: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3 intersection_of: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3 intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: capable_of GO:0002349 ! histamine production involved in inflammatory response relationship: capable_of GO:0002539 ! prostaglandin production involved in inflammatory response relationship: capable_of GO:0002660 ! positive regulation of peripheral tolerance induction relationship: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response relationship: capable_of GO:0030210 ! heparin biosynthetic process relationship: develops_from CL:0000831 ! mast cell progenitor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_part GO:0030141 ! secretory granule relationship: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3 relationship: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3 relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain [Term] id: CL:0000098 name: sensory epithelial cell namespace: cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! receptor cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000099 name: interneuron namespace: cell def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A08.663.358] xref: BTO:0003811 xref: FBbt:00005125 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:0000540 ! neuron [Term] id: CL:0000100 name: motor neuron namespace: cell def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:A08.663.655.500, PMID:16875686] synonym: "anterior horn cell" NARROW [] synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron relationship: synapsed_to CL:0000187 ! muscle cell [Term] id: CL:0000101 name: sensory neuron namespace: cell def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] xref: BTO:0001037 xref: FBbt:00005124 xref: FMA:84649 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000102 name: polymodal neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000103 name: bipolar neuron namespace: cell def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442] xref: FMA:67282 is_a: CL:0000099 ! interneuron [Term] id: CL:0000104 name: multipolar neuron namespace: cell def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm] xref: FMA:67287 is_a: CL:0000540 ! neuron [Term] id: CL:0000105 name: pseudounipolar neuron namespace: cell def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm] xref: FMA:67305 is_a: CL:0000540 ! neuron [Term] id: CL:0000106 name: unipolar neuron namespace: cell def: "Neuron with one neurite that extends from the cell body." [FMA:67278, GOC:nv] xref: FMA:67278 is_a: CL:0000540 ! neuron [Term] id: CL:0000107 name: autonomic neuron namespace: cell def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron namespace: cell def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: BTO:0004902 xref: FMA:84796 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron [Term] id: CL:0000109 name: adrenergic neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000110 name: peptidergic neuron namespace: cell is_a: CL:0000540 ! neuron relationship: capable_of GO:0002790 ! peptide secretion [Term] id: CL:0000111 name: peripheral neuron namespace: cell def: "A neuron that is part of nerve found outside the central nervous system." [ISBN:0721662544] xref: FMA:84664 is_a: CL:0000540 ! neuron [Term] id: CL:0000112 name: columnar neuron namespace: cell synonym: "columnar neuron" RELATED [] is_a: CL:0000540 ! neuron [Term] id: CL:0000113 name: mononuclear phagocyte namespace: cell def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] xref: BTO:0001433 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000114 name: surface ectodermal cell namespace: cell synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000115 name: endothelial cell namespace: cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000116 name: pioneer neuron namespace: cell def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [GOC:cvs, GOC:tfm] xref: FBbt:00005128 is_a: CL:0000540 ! neuron [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) namespace: cell is_a: CL:2000029 ! central nervous system neuron relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000118 name: basket cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000119 name: cerebellar Golgi cell namespace: cell def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [] {comment="NIFSTD:sao1415726815"} synonym: "cerebellar Golgi neuron" EXACT [] synonym: "cerebellum Golgi cell" EXACT [] synonym: "Golgi cell" EXACT [] synonym: "Golgi neuron" EXACT [] is_a: CL:0011005 ! GABAergic interneuron relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: CL:0000120 name: granule cell namespace: cell xref: BTO:0003393 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000121 name: Purkinje cell namespace: cell def: "The output neuron of the cerebellar cortex." [MESH:A08.186.211.132.810.428.200.212.600] synonym: "cerebellar Purkinje cell" EXACT [] synonym: "cerebellum Purkinje cell" EXACT [] synonym: "Purkinje neuron" EXACT [] synonym: "Purkinje's cell" EXACT [] xref: BTO:0001011 xref: CALOHA:TS-0845 xref: FMA:67969 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0000527 ! efferent neuron relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: CL:0000122 name: stellate cell namespace: cell xref: BTO:0002316 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) namespace: cell is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000124 name: glial cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005144 is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000340 ! glioblast (sensu Nematoda and Protostomia) [Term] id: CL:0000125 name: glial cell namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A08.637] synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000030 {comment="It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation."} ! glioblast [Term] id: CL:0000126 name: macroglial cell namespace: cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] synonym: "macrogliocyte" EXACT [] xref: BTO:0000771 xref: CALOHA:TS-2027 xref: FMA:54538 is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:A08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. synonym: "astrocytic glia" EXACT [] xref: BTO:0000099 xref: CALOHA:TS-0060 xref: FMA:54537 is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:A08.637.600, MESH:D009836] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [PMID:8734446] xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 is_a: CL:0000126 {is_inferred="true"} ! macroglial cell relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000129 name: microglial cell namespace: cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" EXACT [] synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 xref: FMA:54540 is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata) is_a: CL:0000878 ! central nervous system macrophage intersection_of: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: capable_of GO:0045087 ! innate immune response intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: part_of UBERON:0001017 ! central nervous system relationship: capable_of GO:0045087 ! innate immune response relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000130 name: neuron associated cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000131 name: gut endothelial cell namespace: cell is_a: CL:0000115 ! endothelial cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000132 name: corneal endothelial cell namespace: cell def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [GOC:tfm, MESH:A09.371.060.067.31] xref: CALOHA:TS-0172 xref: FMA:70614 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000133 name: neurectodermal cell namespace: cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell namespace: cell alt_id: CL:0002452 def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. synonym: "BMSC" NARROW [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED PLURAL [] synonym: "MSC" RELATED [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000219 ! motile cell is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: capable_of GO:0001649 ! osteoblast differentiation intersection_of: capable_of GO:0016477 ! cell migration intersection_of: capable_of GO:0030182 ! neuron differentiation intersection_of: capable_of GO:0030855 ! epithelial cell differentiation intersection_of: capable_of GO:0045444 ! fat cell differentiation intersection_of: capable_of GO:0055007 ! cardiac muscle cell differentiation intersection_of: capable_of GO:0060591 ! chondroblast differentiation intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin intersection_of: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: capable_of GO:0001649 ! osteoblast differentiation relationship: capable_of GO:0016477 ! cell migration relationship: capable_of GO:0030182 ! neuron differentiation relationship: capable_of GO:0030855 ! epithelial cell differentiation relationship: capable_of GO:0045444 ! fat cell differentiation relationship: capable_of GO:0055007 ! cardiac muscle cell differentiation relationship: capable_of GO:0060591 ! chondroblast differentiation relationship: has_plasma_membrane_part PR:000001345 ! endoglin relationship: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: CL:0000135 name: fibrocyte namespace: cell def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Fibrocyte, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999] comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. xref: FMA:63879 is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II intersection_of: capable_of GO:0045766 ! positive regulation of angiogenesis relationship: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: capable_of GO:0045766 ! positive regulation of angiogenesis relationship: develops_from CL:0000057 ! fibroblast [Term] id: CL:0000136 name: fat cell namespace: cell alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A11.329.114] synonym: "adipocyte" EXACT [] synonym: "adipose cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000137 name: osteocyte namespace: cell def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A11.329.629.500] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 synonym: "bone cell" BROAD [] xref: BTO:0002038 xref: CALOHA:TS-1167 xref: FMA:66779 xref: VSAO:0000124 is_a: CL:0001035 ! bone cell relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0000138 name: chondrocyte namespace: cell def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:A11.329.171] synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000058 ! chondroblast relationship: RO:0001025 UBERON:0002418 ! cartilage tissue [Term] id: CL:0000140 name: odontocyte namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034] is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000060 ! odontoblast relationship: develops_from CL:0000134 ! mesenchymal stem cell relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000141 name: cementocyte namespace: cell def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901] comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def). xref: FMA:63003 is_a: CL:0000137 ! osteocyte relationship: develops_from CL:0000061 ! cementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: CL:0000142 name: hyalocyte namespace: cell def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178] synonym: "vitreous cell" RELATED [] xref: BTO:0004271 xref: FMA:70620 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000143 name: guidepost cell namespace: cell is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000144 name: obsolete cell by function namespace: cell def: "OBSOLETE: A classification of cells by their primary end goal or behavior." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000145 name: professional antigen presenting cell namespace: cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. synonym: "APC" BROAD [] is_a: CL:0000473 ! defensive cell relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: CL:0000146 name: simple columnar epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000147 name: pigment cell namespace: cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000148 name: melanocyte namespace: cell alt_id: CL:0000572 def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl] synonym: "melanophore" NARROW [] xref: BTO:0000847 xref: CALOHA:TS-0613 xref: FMA:70545 xref: VHOG:0001679 is_a: CL:0000147 {is_inferred="true"} ! pigment cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000147 ! pigment cell intersection_of: develops_from CL:0000541 ! melanoblast intersection_of: has_part GO:0042470 ! melanosome relationship: develops_from CL:0000541 ! melanoblast relationship: has_part GO:0042470 ! melanosome [Term] id: CL:0000149 name: visual pigment cell namespace: cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell namespace: cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0006799 ! glandular epithelium [Term] id: CL:0000151 name: secretory cell namespace: cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0032940 ! secretion by cell relationship: capable_of GO:0032940 ! secretion by cell [Term] id: CL:0000152 name: exocrine cell namespace: cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] xref: FMA:16014 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002365 ! exocrine gland relationship: part_of UBERON:0002365 ! exocrine gland [Term] id: CL:0000153 name: GAG secreting cell namespace: cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] synonym: "hyaluronic acid secreting cell" EXACT [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0009306 ! protein secretion relationship: capable_of GO:0009306 ! protein secretion [Term] id: CL:0000155 name: peptic cell namespace: cell def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [GOC:tfm] synonym: "chief cell of stomach" EXACT [] synonym: "gastric chief cell" EXACT [] synonym: "pepsinogen secreting cell" EXACT [] synonym: "zymogenic cell" EXACT [] xref: FMA:62902 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000156 name: obsolete antibody secreting cell namespace: cell def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." [] comment: Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000157 name: surfactant secreting cell namespace: cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0043129 ! surfactant homeostasis relationship: capable_of GO:0043129 ! surfactant homeostasis [Term] id: CL:0000158 name: Clara cell namespace: cell def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [GOC:tfm, PMID:12107102, PMID:7905712] synonym: "bronchiolar non-ciliated cell" EXACT [] synonym: "Clara cell of bronchiole" EXACT [] xref: BTO:0004811 xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell intersection_of: CL:0002328 ! bronchial epithelial cell intersection_of: bearer_of PATO:0001789 ! domed intersection_of: capable_of GO:0032940 ! secretion by cell intersection_of: capable_of GO:0043129 ! surfactant homeostasis intersection_of: has_plasma_membrane_part GO:0005902 ! microvillus relationship: bearer_of PATO:0001789 ! domed relationship: capable_of GO:0032940 ! secretion by cell relationship: capable_of GO:0043129 ! surfactant homeostasis relationship: has_plasma_membrane_part GO:0005902 ! microvillus [Term] id: CL:0000159 name: seromucus secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell namespace: cell def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A03.492.411.369.320] synonym: "chalice cell" EXACT [] xref: BTO:0001540 xref: FMA:13148 xref: http://en.wikipedia.org/wiki/Goblet_cell is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: capable_of GO:0070254 ! mucus secretion [Term] id: CL:0000161 name: acid secreting cell namespace: cell is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0046717 ! acid secretion relationship: capable_of GO:0046717 ! acid secretion [Term] id: CL:0000162 name: parietal cell namespace: cell def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [GOC:tfm, ISBN:0517223651] synonym: "oxyntic cell" EXACT [] xref: BTO:0001780 xref: FMA:62901 is_a: CL:0000161 ! acid secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000163 name: endocrine cell namespace: cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A06.407] synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0060986 ! endocrine hormone secretion relationship: capable_of GO:0060986 ! endocrine hormone secretion relationship: part_of UBERON:0002368 ! endocrine gland [Term] id: CL:0000164 name: enteroendocrine cell namespace: cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] xref: BTO:0003865 xref: FMA:62930 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell namespace: cell def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A06.688] synonym: "neurosecretory cell" EXACT [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000166 name: chromaffin cell namespace: cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A06.224.161] synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 is_a: CL:0000568 ! APUD cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000167 name: peptide hormone secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030072 ! peptide hormone secretion relationship: capable_of GO:0030072 ! peptide hormone secretion [Term] id: CL:0000168 name: insulin secreting cell namespace: cell xref: BTO:0000783 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030073 ! insulin secretion relationship: capable_of GO:0030073 ! insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell namespace: cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. synonym: "B-cell of pancreatic islet" EXACT [FMA:70586] synonym: "beta cell" BROAD [ZFA:0009102] synonym: "beta cell islet" RELATED [MA:0002419] synonym: "beta cell of pancreatic islet" EXACT [FMA:70586] synonym: "insulin-secreting cell" EXACT [FMA:70586] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [FMA:70586] synonym: "pancreatic beta cell" EXACT [FMA:70586] synonym: "pancreatic islet core" EXACT [MA:0002419] synonym: "type B enteroendocrine cell" EXACT [FMA:70586] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell is_a: CL:0000164 {is_inferred="true"} ! enteroendocrine cell is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0030073 ! insulin secretion intersection_of: part_of UBERON:0000006 ! islet of Langerhans relationship: capable_of GO:0030073 ! insulin secretion relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans [Term] id: CL:0000170 name: glucagon secreting cell namespace: cell def: "A cell that secretes glucagon." [GOC:tfm] synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070091 ! glucagon secretion relationship: capable_of GO:0070091 ! glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell namespace: cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] synonym: "alpha cell of iselt of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0002067 ! type A enterocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0002067 ! type A enterocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: capable_of GO:0070091 ! glucagon secretion relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000172 name: somatostatin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070253 ! somatostatin secretion relationship: capable_of GO:0070253 ! somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell namespace: cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000174 name: steroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035929 ! steroid hormone secretion relationship: capable_of GO:0035929 ! steroid hormone secretion [Term] id: CL:0000175 name: luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A05.360.319.114.630.278.400] synonym: "lutein cell" EXACT [] xref: BTO:0003939 xref: FMA:18688 is_a: CL:0000179 ! progesterone secreting cell is_a: CL:0002132 ! stromal cell of ovary relationship: capable_of GO:0042701 ! progesterone secretion relationship: part_of UBERON:0002512 ! corpus luteum [Term] id: CL:0000176 name: ecdysteroid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0045457 ! ecdysteroid secretion relationship: capable_of GO:0045457 ! ecdysteroid secretion [Term] id: CL:0000177 name: testosterone secreting cell namespace: cell is_a: CL:0000593 ! androgen secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035936 ! testosterone secretion relationship: capable_of GO:0035936 ! testosterone secretion [Term] id: CL:0000178 name: Leydig cell namespace: cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120] comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated synonym: "interstitial cell" BROAD [] synonym: "interstitial cell of Leydig" EXACT [] xref: BTO:0000755 xref: CALOHA:TS-1150 xref: EMAPA:29655 xref: FMA:72297 is_a: CL:0000177 ! testosterone secreting cell relationship: part_of UBERON:0005212 ! Leydig cell region of testis [Term] id: CL:0000179 name: progesterone secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0042701 ! progesterone secretion relationship: capable_of GO:0042701 ! progesterone secretion [Term] id: CL:0000180 name: estradiol secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035938 ! estradiol secretion relationship: capable_of GO:0035938 ! estradiol secretion [Term] id: CL:0000181 name: metabolising cell namespace: cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000182 name: hepatocyte namespace: cell def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:A11.436.348, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 is_a: CL:0000066 ! epithelial cell is_a: CL:0000181 ! metabolising cell is_a: CL:0000417 ! endopolyploid cell is_a: CL:0002371 ! somatic cell relationship: capable_of GO:0006699 ! bile acid biosynthetic process relationship: capable_of GO:0044237 ! cellular metabolic process relationship: capable_of GO:0098754 ! detoxification relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000183 name: contractile cell namespace: cell def: "A cell whose primary function is to shorten." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000185 name: myoepithelial cell namespace: cell def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544] synonym: "basket epithelial cell" EXACT [] synonym: "myoepitheliocyte" EXACT [] xref: BTO:0002309 xref: CALOHA:TS-2379 xref: FMA:67799 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000186 name: myofibroblast cell namespace: cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469] comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. synonym: "MFB" EXACT [PMID:8731193] is_a: CL:0000183 ! contractile cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000187 name: muscle cell namespace: cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A11.620] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FBbt:00005074 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000056 ! myoblast [Term] id: CL:0000188 name: cell of skeletal muscle namespace: cell def: "A somatic cell located in skeletal muscle." [GOC:tfm] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 is_a: CL:0002371 ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000189 name: slow muscle cell namespace: cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908] synonym: "slow muscle fiber" RELATED [ISBN:0815316208] xref: FMA:84448 is_a: CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000857 ! slow muscle myoblast [Term] id: CL:0000190 name: fast muscle cell namespace: cell def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908] synonym: "glycolytic muscle fiber" EXACT [] is_a: CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000858 ! fast muscle myoblast [Term] id: CL:0000192 name: smooth muscle cell namespace: cell alt_id: CL:0000191 def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:A11.620.520, MESH:D032389, PMID:9315361] synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" EXACT [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast [Term] id: CL:0000193 name: cardiac muscle cell (sensu Arthopoda) namespace: cell alt_id: CL:0000466 def: "A striated muscle cell of an arthropod heart that participates in heart contraction." [MESH:A11.620.500] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) [Term] id: CL:0000194 name: obsolete nodal cardiac cell namespace: cell comment: Consider CL:0002072. is_obsolete: true [Term] id: CL:0000195 name: obsolete Purkinje fiber namespace: cell is_obsolete: true [Term] id: CL:0000196 name: flight muscle cell namespace: cell is_a: CL:0008003 ! somatic muscle myotube relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000197 name: receptor cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000198 name: pain receptor cell namespace: cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A08.800.550.700.650] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship synonym: "nociceptor" EXACT [] synonym: "nocireceptor" EXACT [] is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000199 name: mechanoreceptor cell namespace: cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A08.800.550.700.500] synonym: "mechanoreceptor" RELATED [MP:0000972] is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception relationship: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception [Term] id: CL:0000200 name: touch receptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch relationship: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch [Term] id: CL:0000202 name: auditory hair cell namespace: cell alt_id: CL:0000201 def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A08.663.650.250] comment: In mammals these cells are located in the organ of Corti. synonym: "auditory receptor cell" EXACT [] synonym: "cochlear hair cell" EXACT [] synonym: "inner ear hair cell" RELATED [GO:0060119] synonym: "inner ear receptor cell" RELATED [GO:0060119] xref: FMA:62364 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0002374 ! ear hair cell is_a: CL:0002491 ! auditory epithelial cell relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound relationship: part_of UBERON:0002227 ! spiral organ of cochlea [Term] id: CL:0000203 name: gravity sensitive cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: capable_of GO:0070999 ! detection of mechanical stimulus involved in sensory perception of gravity relationship: capable_of GO:0070999 ! detection of mechanical stimulus involved in sensory perception of gravity [Term] id: CL:0000204 name: acceleration receptive cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000205 name: thermoreceptor cell namespace: cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:A08.800.550.700.840, MP:0000971] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: capable_of GO:0050960 ! detection of temperature stimulus involved in thermoception relationship: capable_of GO:0050960 ! detection of temperature stimulus involved in thermoception [Term] id: CL:0000206 name: chemoreceptor cell namespace: cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A08.800.550.700.120] is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception [Term] id: CL:0000207 name: olfactory receptor cell namespace: cell synonym: "odorant receptor cell" EXACT [] synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: BTO:0004185 xref: FMA:67860 xref: Wikipedia:Olfactory_receptor_neuron is_a: CL:0000206 ! chemoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell relationship: part_of UBERON:0005725 ! olfactory system [Term] id: CL:0000208 name: pH receptor cell namespace: cell is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000209 name: taste receptor cell namespace: cell def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [GOC:tfm, ISBN:0618947256] synonym: "taste bud cell" EXACT [] xref: FMA:67910 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of UBERON:0002025 ! stratum basale of epidermis [Term] id: CL:0000210 name: photoreceptor cell namespace: cell def: "A cell specialized to detect and transduce light." [MESH:A08.663.650.650] xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FBbt:00004211 xref: FMA:86740 is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception [Term] id: CL:0000211 name: electrically active cell namespace: cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000212 name: absorptive cell namespace: cell def: "A cell that takes up and metabolizes substances." [CL:CVS] is_a: CL:0000003 ! native cell [Term] id: CL:0000213 name: lining cell namespace: cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell namespace: cell def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474] synonym: "hyaluronic acid secreting cell" EXACT [] synonym: "synoviocyte" EXACT [] xref: BTO:0003652 xref: CALOHA:TS-0995 xref: FMA:66786 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint [Term] id: CL:0000215 name: barrier cell namespace: cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000003 ! native cell [Term] id: CL:0000216 name: Sertoli cell namespace: cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A05.360.444.849.789] xref: BTO:0001238 xref: CALOHA:TS-0922 xref: FMA:72298 xref: VHOG:0001348 is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 {is_inferred="true"} ! supportive cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000630 ! supportive cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis [Term] id: CL:0000217 name: insulating cell namespace: cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A08.637.800] synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 is_a: CL:0000217 ! insulating cell is_a: CL:0000328 ! myelin accumulating cell is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell [Term] id: CL:0000219 name: motile cell namespace: cell def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0048870 ! cell motility relationship: capable_of GO:0048870 ! cell motility [Term] id: CL:0000220 name: obsolete cell by lineage namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000221 name: ectodermal cell namespace: cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:A16.254.425.273] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000924 ! ectoderm [Term] id: CL:0000222 name: mesodermal cell namespace: cell def: "A cell of the middle germ layer of the embryo." [MESH:A16.254.425.660] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000926 ! mesoderm [Term] id: CL:0000223 name: endodermal cell namespace: cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:A16.254.425.407] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000925 ! endoderm [Term] id: CL:0000224 name: obsolete cell by nuclear number namespace: cell def: "OBSOLETE: A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000225 name: anucleate cell namespace: cell def: "A cell that lacks a nucleus." [FB:ma] synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001405 ! anucleate disjoint_from: CL:0002242 ! nucleate cell relationship: bearer_of PATO:0001405 ! anucleate [Term] id: CL:0000226 name: single nucleate cell namespace: cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000227 name: binucleate cell namespace: cell is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001406 ! binucleate relationship: bearer_of PATO:0001406 ! binucleate [Term] id: CL:0000228 name: multinucleate cell namespace: cell def: "A cell with more than one nucleus." [FB:ma] synonym: "syncitium" EXACT [] synonym: "syncytial cell" EXACT [] synonym: "syncytium" EXACT [] xref: AEO:0000203 xref: WBbt:0008074 is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000229 name: obsolete lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. is_obsolete: true [Term] id: CL:0000230 name: obsolete T lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. is_obsolete: true [Term] id: CL:0000231 name: obsolete B lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000232 name: erythrocyte namespace: cell def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A11.118.290] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: bearer_of PATO:0002039 ! biconcave intersection_of: capable_of GO:0008015 ! blood circulation intersection_of: capable_of GO:0015671 ! oxygen transport intersection_of: lacks_part GO:0005840 ! ribosome intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: bearer_of PATO:0002039 ! biconcave relationship: capable_of GO:0008015 ! blood circulation relationship: capable_of GO:0015671 ! oxygen transport relationship: develops_from CL:0000558 ! reticulocyte relationship: lacks_part GO:0005840 ! ribosome relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000233 name: platelet namespace: cell def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:A11.118.188, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831] comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. synonym: "anucleate thrombocyte" EXACT [] synonym: "blood platelet" EXACT [] synonym: "enucleate thrombocyte" EXACT [] xref: BTO:0000132 xref: CALOHA:TS-0803 xref: FMA:62851 is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001405 ! anucleate intersection_of: bearer_of PATO:0001874 ! discoid intersection_of: capable_of GO:0007596 ! blood coagulation intersection_of: capable_of GO:0008015 ! blood circulation relationship: bearer_of PATO:0001405 ! anucleate relationship: bearer_of PATO:0001874 ! discoid relationship: capable_of GO:0007596 ! blood coagulation relationship: capable_of GO:0008015 ! blood circulation relationship: develops_from CL:0000556 ! megakaryocyte [Term] id: CL:0000234 name: phagocyte namespace: cell def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] xref: BTO:0001044 xref: FMA:83806 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0006909 ! phagocytosis relationship: capable_of GO:0006909 ! phagocytosis [Term] id: CL:0000235 name: macrophage namespace: cell def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 is_a: CL:0000234 ! phagocyte is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: capable_of GO:0006909 ! phagocytosis intersection_of: capable_of GO:0031268 ! pseudopodium organization relationship: capable_of GO:0006909 ! phagocytosis relationship: capable_of GO:0031268 ! pseudopodium organization relationship: develops_from CL:0000576 ! monocyte [Term] id: CL:0000236 name: B cell namespace: cell def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 xref: VHOG:0001480 is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: capable_of GO:0019724 ! B cell mediated immunity relationship: capable_of GO:0019724 ! B cell mediated immunity relationship: develops_from CL:0000826 ! pro-B cell [Term] id: CL:0000237 name: keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell is_a: CL:0002077 ! ecto-epithelial cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000238 name: non keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell [Term] id: CL:0000239 name: brush border epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000240 name: stratified squamous epithelial cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000241 name: stratified cuboidal epithelial cell namespace: cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000242 name: Merkel cell namespace: cell def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A08.800.550.700.500.425] synonym: "Merkel's cell" EXACT [] xref: FMA:70548 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000312 {source="PMID:19782676"} ! keratinocyte is_a: CL:0000710 ! neurecto-epithelial cell relationship: part_of UBERON:0002025 ! stratum basale of epidermis [Term] id: CL:0000243 name: glial cell (sensu Vertebrata) namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A08.637] is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000244 name: transitional epithelial cell namespace: cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544] xref: FMA:66778 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000245 name: obsolete passage cell namespace: cell def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208] comment: replaced_by: PO:0000353 is_obsolete: true [Term] id: CL:0000246 name: Mauthner neuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000247 name: Rohon-Beard neuron namespace: cell def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [VHOG:0001484] synonym: "RB neuron" RELATED [VHOG:0001484] synonym: "Rohon Beard cell" EXACT [VHOG:0001484] synonym: "Rohon-Beard cell" EXACT [] xref: AAO:0010316 xref: EFO:0003711 xref: VHOG:0001484 is_a: CL:0000531 ! primary sensory neuron [Term] id: CL:0000248 name: obsolete microsporocyte namespace: cell def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208] comment: replaced_by: PO:0020047 synonym: "pollen mother cell" EXACT [] synonym: "primary sporogenous cell" EXACT [] is_obsolete: true [Term] id: CL:0000249 name: hatching gland cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000250 name: obsolete megaspore namespace: cell def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208] comment: replaced_by: PO:0020019 is_obsolete: true [Term] id: CL:0000251 name: extramedullary cell namespace: cell is_a: CL:0000101 ! sensory neuron [Term] id: CL:0000252 name: obsolete microspore namespace: cell def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208] comment: replaced_by: PO:0020048 is_obsolete: true [Term] id: CL:0000253 name: eurydendroid cell namespace: cell is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000254 name: obsolete egg cell namespace: cell def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [TAIR:lr] comment: replaced_by: PO:0020094 synonym: "female gametophyte egg cell" EXACT [] is_obsolete: true [Term] id: CL:0000255 name: eukaryotic cell namespace: cell is_a: CL:0000003 ! native cell disjoint_from: CL:0000520 ! prokaryotic cell [Term] id: CL:0000256 name: uric acid accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000257 name: Mycetozoan cell namespace: cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000258 name: obsolete fiber tracheid namespace: cell def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208] comment: replaced_by: PO:0000355 is_obsolete: true [Term] id: CL:0000259 name: aggregate cell namespace: cell def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000260 name: obsolete mucilage cell namespace: cell def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208] comment: replaced_by: PO:0000373 is_obsolete: true [Term] id: CL:0000261 name: anterior cell namespace: cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000262 name: obsolete guard mother cell namespace: cell def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [ISBN:0471245208] comment: replaced_by: PO:0000351 is_obsolete: true [Term] id: CL:0000263 name: vegetative cell (sensu Mycetozoa) namespace: cell def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB] synonym: "amoeba" EXACT [] is_a: CL:0000257 ! Mycetozoan cell [Term] id: CL:0000264 name: obsolete phloem initial namespace: cell def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208] comment: replaced_by: PO:0000400 synonym: "phloem mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000265 name: anterior like cell namespace: cell def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB] synonym: "ALC" EXACT [] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000266 name: obsolete meristemoid namespace: cell def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208] comment: replaced_by: PO:0004011 is_obsolete: true [Term] id: CL:0000267 name: prespore cell namespace: cell def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000268 name: obsolete sieve element namespace: cell def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000269 name: prestalk cell namespace: cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000270 name: obsolete subsidiary cell namespace: cell def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520] comment: replaced_by: PO:0000284 is_obsolete: true [Term] id: CL:0000271 name: prestalk A cell namespace: cell def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstA" EXACT [] synonym: "pstAO" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000272 name: obsolete cambial initial namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208] comment: replaced_by PO:0000295 is_obsolete: true [Term] id: CL:0000273 name: prestalk AB cell namespace: cell def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstAB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000275 name: prestalk B cell namespace: cell def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB] synonym: "pstB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000276 name: obsolete sclerenchyma cell namespace: cell def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208] comment: replaced_by: PO:0000077 is_obsolete: true [Term] id: CL:0000277 name: obsolete prestalk I cell namespace: cell def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB] comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology. is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000278 name: obsolete central cell namespace: cell def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr] comment: replaced_by: PO:0020090 is_obsolete: true [Term] id: CL:0000279 name: prestalk 0 cell namespace: cell def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000280 name: obsolete generative cell namespace: cell def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr] comment: replaced_by: PO:0020097 is_obsolete: true [Term] id: CL:0000281 name: pstAB/ALC namespace: cell def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000282 name: obsolete trichome namespace: cell def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806] comment: replaced_by: PO:0000282 is_obsolete: true [Term] id: CL:0000283 name: pstO/ALC namespace: cell def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000284 name: obsolete companion cell namespace: cell def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322] comment: replaced_by: PO:0000071 is_obsolete: true [Term] id: CL:0000285 name: stalk cell namespace: cell def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000286 name: hyphal cell namespace: cell def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X] is_a: CL:0000521 ! fungal cell [Term] id: CL:0000287 name: eye photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye [Term] id: CL:0000288 name: obsolete synergid namespace: cell def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208] comment: replaced_by: PO:0000191 is_obsolete: true [Term] id: CL:0000289 name: chemotactic amoeboid cell (sensu Mycetozoa) namespace: cell def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) is_a: CL:0000732 ! amoeboid cell [Term] id: CL:0000290 name: obsolete xylem fiber cell namespace: cell def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208] comment: replaced_by: PO:0000274 is_obsolete: true [Term] id: CL:0000291 name: spore (sensu Mycetozoa) namespace: cell def: "Dormant cell protected by a tri-layer spore coat. The spore has an elliptical shape and is approximately 6-9 microns by 3 microns." [DDB_REF:5048, DictyBase:DDB, PMID:4338436] xref: DDANAT:0000414 is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000292 name: obsolete guard cell namespace: cell def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208] comment: replaced_by: PO:0000293 synonym: "stomatal guard cell" EXACT [] is_obsolete: true [Term] id: CL:0000293 name: structural cell namespace: cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000003 ! native cell [Term] id: CL:0000294 name: obsolete sieve cell namespace: cell def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000295 name: somatotropin secreting cell namespace: cell alt_id: CL:0000471 def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl] synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030252 ! growth hormone secretion relationship: capable_of GO:0030252 ! growth hormone secretion [Term] id: CL:0000296 name: obsolete vegetative cell namespace: cell def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr] comment: replaced_by: PO:0020099 is_obsolete: true [Term] id: CL:0000297 name: obsolete socket cell namespace: cell def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806] comment: replaced_by: PO:0000115 is_obsolete: true [Term] id: CL:0000298 name: obsolete xylem element namespace: cell def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [ISBN:0471245208] comment: replaced_by: PO:0000273 is_obsolete: true [Term] id: CL:0000299 name: obsolete trichoblast namespace: cell def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208] comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262). is_obsolete: true [Term] id: CL:0000300 name: gamete namespace: cell def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FBbt:00005412 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: capable_of GO:0009566 ! fertilization relationship: bearer_of PATO:0001375 ! haploid relationship: capable_of GO:0009566 ! fertilization [Term] id: CL:0000301 name: pole cell namespace: cell xref: FBbt:00000092 is_a: CL:0000670 ! primordial germ cell [Term] id: CL:0000302 name: obsolete IgM B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000303 name: obsolete IgG B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000304 name: obsolete IgA B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000305 name: obsolete IgE B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000306 name: crystallin accumulating cell namespace: cell synonym: "lens cell" EXACT [] xref: FBbt:00004193 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell namespace: cell alt_id: CL:1000474 def: "An epithelial cell found in the trachea." [GOC:tfm] comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' synonym: "tracheocyte" EXACT [] xref: FMA:74793 is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from CL:0000377 ! tracheoblast relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:0000308 name: metal ion accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000309 name: copper accumulating cell namespace: cell synonym: "cuprophilic cell" EXACT [] is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000310 name: iron accumulating cell namespace: cell is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000312 name: keratinocyte namespace: cell alt_id: CL:0002185 def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:A11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116] comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. synonym: "keratinized cell of epidermis" EXACT [] synonym: "malpighian cell" EXACT [] xref: BTO:0000667 xref: CALOHA:TS-0500 xref: FMA:62879 is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell is_a: CL:0000362 {is_inferred="true"} ! epidermal cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: capable_of GO:0002775 ! antimicrobial peptide production relationship: capable_of GO:0002776 ! antimicrobial peptide secretion relationship: capable_of GO:0090023 ! positive regulation of neutrophil chemotaxis relationship: part_of UBERON:0001003 ! skin epidermis [Term] id: CL:0000313 name: serous secreting cell namespace: cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000314 name: milk secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000315 name: tears secreting cell namespace: cell def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A12.200.882] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000316 name: obsolete ray initial namespace: cell def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208] comment: replaced_by: PO:0000082 is_obsolete: true [Term] id: CL:0000317 name: sebum secreting cell namespace: cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A12.200.702] synonym: "sebocyte" EXACT [] is_a: CL:0000152 ! exocrine cell is_a: CL:2000021 ! sebaceous gland native cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland [Term] id: CL:0000318 name: sweat secreting cell namespace: cell def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A12.200.849] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000319 name: mucus secreting cell namespace: cell synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070254 ! mucus secretion relationship: capable_of GO:0070254 ! mucus secretion [Term] id: CL:0000320 name: obsolete megasporocyte namespace: cell def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208] comment: replaced_by: PO:0000431 synonym: "archesporial cell" EXACT [] synonym: "megaspore mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000321 name: seminal fluid secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000322 name: pneumocyte namespace: cell def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144] synonym: "alveolar epithelial cell" EXACT [] synonym: "pneumonocyte" EXACT [] xref: BTO:0000395 xref: CALOHA:TS-2168 xref: FMA:62499 is_a: CL:0000066 ! epithelial cell relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium [Term] id: CL:0000323 name: lysozyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000324 name: metanephric mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal stem cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000325 name: stuff accumulating cell namespace: cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: ubprop:upper_level is_a: CL:0000003 ! native cell [Term] id: CL:0000326 name: glycogen accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell is_a: CL:0000499 ! stromal cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion [Term] id: CL:0000328 name: myelin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000329 name: oxygen accumulating cell namespace: cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0015671 ! oxygen transport relationship: capable_of GO:0015671 ! oxygen transport [Term] id: CL:0000330 name: obsolete collenchymal cell namespace: cell def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208] comment: replaced_by: PO:0000075 is_obsolete: true [Term] id: CL:0000331 name: obsolete tracheid namespace: cell def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208] comment: replaced_by: PO:0000301 is_obsolete: true [Term] id: CL:0000332 name: obsolete atrichoblast namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819] comment: replaced_by: PO:0020090 synonym: "non-hair cell" RELATED [] is_obsolete: true [Term] id: CL:0000333 name: migratory neural crest cell namespace: cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) namespace: cell synonym: "yeast-form" RELATED [] xref: BTO:0002307 xref: FAO:0000032 is_a: CL:0000521 ! fungal cell [Term] id: CL:0000335 name: mesenchyme condensation cell namespace: cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0008019 ! mesenchymal cell [Term] id: CL:0000336 name: adrenal medulla chromaffin cell namespace: cell alt_id: CL:1000422 def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland] synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262] xref: FMA:69262 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: develops_from CL:0000011 ! migratory trunk neural crest cell relationship: part_of UBERON:0001236 ! adrenal medulla [Term] id: CL:0000337 name: neuroblast (sensu Vertebrata) namespace: cell def: "An embryonic cell that develops into a nerve cell or neuron." [FMA:70563] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) namespace: cell synonym: "neuroblast" BROAD [] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) namespace: cell def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256] synonym: "spongioblast" EXACT [] xref: FMA:70564 is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) [Term] id: CL:0000340 name: glioblast (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000030 ! glioblast is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000147 ! pigment cell [Term] id: CL:0000342 name: pigment cell (sensu Vertebrata) namespace: cell def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000343 name: visual pigment cell (sensu Vertebrata) namespace: cell def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm] xref: FMA:63846 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception [Term] id: CL:0000344 name: obsolete non-visual cell (sensu Vertebrata) namespace: cell is_obsolete: true [Term] id: CL:0000345 name: dental papilla cell namespace: cell def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544] comment: Merge with odontoblast? is_a: CL:0008019 ! mesenchymal cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001763 ! odontogenic papilla [Term] id: CL:0000346 name: hair follicle dermal papilla cell namespace: cell def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [GOC:tfm, PMID:9893172] comment: Are these really all stem cells? is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0000412 ! dermal papilla relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: part_of UBERON:0000412 ! dermal papilla [Term] id: CL:0000347 name: scleral cell namespace: cell def: "A cell of the sclera of the eye." [GOC:add] is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye namespace: cell def: "A cell of the choroid of the eye." [GOC:add] is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001776 ! optic choroid [Term] id: CL:0000349 name: extraembryonic cell namespace: cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000350 name: amnioserosal cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0010302 ! amnioserosa relationship: part_of UBERON:0010302 ! amnioserosa [Term] id: CL:0000351 name: trophoblast cell namespace: cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A11.936] synonym: "trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0000358 ! blastocyst relationship: part_of UBERON:0000358 ! blastocyst [Term] id: CL:0000352 name: epiblast cell namespace: cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell namespace: cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A11.104] synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000354 name: blastemal cell namespace: cell synonym: "blastema cell" EXACT [] xref: ncithesaurus:Blastemal_Cell is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell namespace: cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. xref: FMA:86767 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000356 name: hair matrix stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000357 name: stratified epithelial stem cell namespace: cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000358 name: sphincter associated smooth muscle cell namespace: cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004590 ! sphincter muscle relationship: part_of UBERON:0004590 ! sphincter muscle [Term] id: CL:0000359 name: vascular associated smooth muscle cell namespace: cell def: "A smooth muscle cell assocatiated with the vasculature." [GOC:dsd, GOC:tfm] synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature [Term] id: CL:0000360 name: morula cell namespace: cell def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A16.254.270.550] is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0000085 ! morula [Term] id: CL:0000361 name: gastrula cell namespace: cell def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A16.254.412] is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0004734 ! gastrula [Term] id: CL:0000362 name: epidermal cell namespace: cell alt_id: CL:1000396 def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007376 ! outer epithelium relationship: part_of UBERON:0007376 ! outer epithelium [Term] id: CL:0000363 name: obsolete axial cell namespace: cell def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208] comment: replaced_by: PO:0000081 is_obsolete: true [Term] id: CL:0000364 name: obsolete ray cell namespace: cell def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000365 name: zygote namespace: cell def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000366 name: obsolete sperm cell (sensu Viridiplantae) namespace: cell def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [ISBN:0471245208] comment: replaced_by: PO:0000084 synonym: "gametophyte sperm cell" RELATED [] synonym: "male gametophyte sperm cell" RELATED [] synonym: "pollen germ cell " RELATED [] is_obsolete: true [Term] id: CL:0000367 name: sheath cell (sensu Nematoda) namespace: cell synonym: "glial cell (sensu Nematoda)" RELATED [] is_a: CL:0000619 ! support cell (sensu Nematoda) [Term] id: CL:0000368 name: obsolete myrosin cell namespace: cell def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208] comment: replaced_by: PO:0000352 is_obsolete: true [Term] id: CL:0000370 name: obsolete transfer cell namespace: cell def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208] comment: replaced_by: PO:0000078 synonym: "intermediary cell" RELATED [] is_obsolete: true [Term] id: CL:0000371 name: protoplast namespace: cell def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X] is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000372 name: tormogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [ISBN:978-0801481253] synonym: "socket cell" BROAD [ISBN:978-0801481253] xref: FBbt:00005171 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) [Term] id: CL:0000373 name: histoblast namespace: cell xref: FBbt:00001789 is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000374 name: trichogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [ISBN:978-0801481253] synonym: "hair cell" BROAD [] xref: BTO:0004744 xref: FBbt:00005169 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) [Term] id: CL:0000375 name: obsolete osteoprogenitor cell namespace: cell xref: BTO:0002051 is_obsolete: true replaced_by: CL:0007010 [Term] id: CL:0000376 name: humidity receptor cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000377 name: tracheoblast namespace: cell is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000378 name: support cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000379 name: sensory processing neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000380 name: thecogen cell namespace: cell def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173] synonym: "fly sheath cell" EXACT [] is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000381 name: neurosecretory neuron namespace: cell xref: FBbt:00005130 is_a: CL:0000151 ! secretory cell is_a: CL:0000527 ! efferent neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0046879 ! hormone secretion relationship: capable_of GO:0046879 ! hormone secretion [Term] id: CL:0000382 name: scolopale cell namespace: cell xref: FBbt:00005219 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000383 name: nephrogenic mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal stem cell relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000384 name: ligament cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005062 is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) [Term] id: CL:0000386 name: attachment cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000387 name: hemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005063 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) relationship: capable_of GO:0035010 {source="PMID:18025161"} ! encapsulation of foreign target relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000388 name: tendon cell namespace: cell def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:957445] synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] is_a: CL:0000135 {is_inferred="true"} ! fibrocyte is_a: CL:0000386 ! attachment cell intersection_of: CL:0000135 ! fibrocyte intersection_of: part_of UBERON:0000043 ! tendon relationship: part_of UBERON:0000043 ! tendon [Term] id: CL:0000389 name: socket cell (sensu Nematoda) namespace: cell is_a: CL:0000619 ! support cell (sensu Nematoda) is_a: CL:0000658 ! cuticle secreting cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000081 ! blood cell [Term] id: CL:0000391 name: podocyte (sensu Diptera) namespace: cell def: "An insect immune cell that develops from plasmatocyte." [PMID:12930778] xref: FBbt:00001688 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000394 ! plasmatocyte [Term] id: CL:0000392 name: crystal cell namespace: cell xref: FMA:63847 is_a: CL:0000391 ! podocyte (sensu Diptera) [Term] id: CL:0000393 name: electrically responsive cell namespace: cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000394 name: plasmatocyte namespace: cell xref: FBbt:00001685 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000395 name: procrystal cell namespace: cell xref: FBbt:00001689 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000396 name: lamellocyte namespace: cell xref: FBbt:00001687 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000397 name: ganglion interneuron namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0000045 ! ganglion relationship: part_of UBERON:0000045 ! ganglion [Term] id: CL:0000398 name: polygonal cell namespace: cell xref: FBbt:00001691 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000399 name: obsolete phloem element namespace: cell def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [GOC:tfm] is_obsolete: true [Term] id: CL:0000400 name: obsolete pavement cell namespace: cell def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289] comment: replaced_by: PO:0000332 is_obsolete: true [Term] id: CL:0000401 name: macrophage (sensu Diptera) namespace: cell xref: FBbt:00001686 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000402 name: CNS interneuron namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000404 name: electrically signaling cell namespace: cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000405 name: neuroepidermoblast namespace: cell xref: FBbt:00005148 is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000406 name: CNS short range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000407 name: scolopidial ligament cell namespace: cell xref: FBbt:00005221 is_a: CL:0000384 ! ligament cell [Term] id: CL:0000408 name: male gamete namespace: cell xref: BTO:0001277 xref: CALOHA:TS-0949 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000300 {is_inferred="true"} ! gamete intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: capable_of GO:0009566 ! fertilization relationship: bearer_of PATO:0001375 ! haploid relationship: capable_of GO:0009566 ! fertilization [Term] id: CL:0000409 name: scolopidial sheath cell namespace: cell xref: FBbt:00005219 is_a: CL:0000618 ! sheath cell [Term] id: CL:0000410 name: CNS long range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000411 name: flatworm hypodermal cell namespace: cell def: "An epithelial cell of the hypodermis of flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm] xref: WBbt:0007846 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000412 name: polyploid cell namespace: cell def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000413 name: haploid cell namespace: cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001375 ! haploid relationship: bearer_of PATO:0001375 ! haploid [Term] id: CL:0000414 name: obsolete cell by ploidy namespace: cell def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0000255 consider: CL:0001034 [Term] id: CL:0000415 name: diploid cell namespace: cell def: "A cell whose nucleus has two haploid genomes." [FB:ma] xref: FMA:72300 is_a: CL:0000003 ! native cell [Term] id: CL:0000416 name: polytene cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000417 name: endopolyploid cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000418 name: arcade cell namespace: cell def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tfm, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells] xref: WBbt:0005793 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000419 name: seam cell namespace: cell def: "An epithelial fate stem cell found in flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm] xref: BTO:0003039 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000420 name: syncytial epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000421 name: coelomocyte namespace: cell def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544] xref: BTO:0002856 xref: WBbt:0005751 is_a: CL:0000080 ! circulating cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000422 name: mitogenic signaling cell namespace: cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000423 name: tip cell namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell namespace: cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135] xref: WBbt:0005812 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000425 name: pore cell namespace: cell def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb] is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000426 name: scaffold cell namespace: cell is_a: CL:0000445 ! apoptosis fated cell [Term] id: CL:0000427 name: GLR cell namespace: cell def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm] is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000428 name: yolk cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000429 name: imaginal disc cell namespace: cell is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000430 name: xanthophore namespace: cell def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005002 ! xanthoblast [Term] id: CL:0000431 name: iridophore namespace: cell def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl] synonym: "guanophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005001 ! iridoblast [Term] id: CL:0000432 name: reticular cell namespace: cell def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651] synonym: "reticulum cell" EXACT [] xref: FMA:62877 is_a: CL:0000057 ! fibroblast [Term] id: CL:0000433 name: obsolete functional megaspore namespace: cell def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr] comment: replaced_by: PO:0000244 is_obsolete: true [Term] id: CL:0000434 name: eccrine cell namespace: cell def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000435 name: alkali secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000436 name: vaginal lubricant secreting cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: part_of UBERON:0000996 ! vagina [Term] id: CL:0000437 name: gonadtroph namespace: cell def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651] synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] synonym: "gonadotrope" EXACT [] synonym: "gonadotrope cell" EXACT [] synonym: "gonadotroph" EXACT [] synonym: "gonadotropic cell" EXACT [] synonym: "pituitary delta cell" EXACT [] xref: BTO:0002482 xref: FMA:83100 is_a: CL:0000438 ! luteinizing hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000438 name: luteinizing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0032275 ! luteinizing hormone secretion relationship: capable_of GO:0032275 ! luteinizing hormone secretion [Term] id: CL:0000439 name: prolactin secreting cell namespace: cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070459 ! prolactin secretion relationship: capable_of GO:0070459 ! prolactin secretion [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell namespace: cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl] synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion relationship: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion [Term] id: CL:0000441 name: follicle stem cell namespace: cell xref: FBbt:00004903 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000442 name: follicular dendritic cell namespace: cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252] comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. xref: BTO:0004267 xref: FMA:83037 is_a: CL:0000473 ! defensive cell [Term] id: CL:0000443 name: calcitonin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0036161 ! calcitonin secretion relationship: capable_of GO:0036161 ! calcitonin secretion [Term] id: CL:0000444 name: obliquely striated muscle cell namespace: cell def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [GOC:DOS, PMID:8720463] comment: Examples include the somatic muscles of nemotodes and cephalopods. is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0002479 ! obliquely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0002479 ! obliquely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000445 name: apoptosis fated cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000446 name: chief cell of parathyroid gland namespace: cell def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651] synonym: "parathyroid chief cell" EXACT [] synonym: "parathyroid gland chief cell" EXACT [] synonym: "parathyroid hormone secreting cell" EXACT [] synonym: "principal cell of parathyroid gland" EXACT [] xref: BTO:0004712 xref: CALOHA:TS-2140 xref: FMA:69078 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002260 ! epithelial cell of parathyroid gland [Term] id: CL:0000447 name: carbohydrate secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white fat cell namespace: cell def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500] synonym: "white adipocyte" RELATED [] synonym: "white adipose cell" EXACT [] synonym: "white fat cell" EXACT [] xref: CALOHA:TS-1119 xref: FMA:83434 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002334 ! preadipocyte relationship: part_of UBERON:0001347 ! white adipose tissue [Term] id: CL:0000449 name: brown fat cell namespace: cell def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A10.165.114.322] synonym: "brown adipocyte" EXACT [] synonym: "brown adipose cell" EXACT [] xref: CALOHA:TS-0099 xref: FMA:83435 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002335 ! brown preadipocyte relationship: part_of UBERON:0001348 ! brown adipose tissue [Term] id: CL:0000451 name: dendritic cell namespace: cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0019882 ! antigen processing and presentation intersection_of: capable_of GO:0045580 ! regulation of T cell differentiation intersection_of: has_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 disjoint_from: CL:0000542 ! lymphocyte relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0019882 ! antigen processing and presentation relationship: capable_of GO:0045580 ! regulation of T cell differentiation relationship: has_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000452 name: thyroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000453 name: Langerhans cell namespace: cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. synonym: "Langerhans' cell" EXACT [] synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: capable_of GO:0002828 ! regulation of type 2 immune response intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: capable_of GO:0002828 ! regulation of type 2 immune response relationship: develops_from CL:0000763 ! myeloid cell relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K [Term] id: CL:0000454 name: epinephrine secreting cell namespace: cell def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093] synonym: "adrenaline secreting cell" EXACT [GO:0048242] synonym: "epinephrin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0048242 ! epinephrine secretion relationship: capable_of GO:0048242 ! epinephrine secretion [Term] id: CL:0000455 name: obsolete starch sheath cell namespace: cell def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520] comment: replaced_by: PO:0004531 is_obsolete: true [Term] id: CL:0000456 name: mineralocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035931 ! mineralocorticoid secretion relationship: capable_of GO:0035931 ! mineralocorticoid secretion [Term] id: CL:0000457 name: biogenic amine secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000458 name: serotonin secreting cell namespace: cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0001820 ! serotonin secretion relationship: capable_of GO:0001820 ! serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell namespace: cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0048243 ! norepinephrine secretion relationship: capable_of GO:0048243 ! norepinephrine secretion [Term] id: CL:0000460 name: glucocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035933 ! glucocorticoid secretion relationship: capable_of GO:0035933 ! glucocorticoid secretion [Term] id: CL:0000462 name: adepithelial cell namespace: cell xref: FBbt:00003219 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000463 name: epidermal cell (sensu arthropoda) namespace: cell def: "An epidermal cell that secretes chitinous cuticle from its apical side." [FlyBase:ds, ISBN:ISBN\:978-0801481253] comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ. is_a: CL:0000362 ! epidermal cell relationship: develops_from CL:0000464 ! epidermoblast [Term] id: CL:0000464 name: epidermoblast namespace: cell def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311] xref: FBbt:00004994 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000465 name: cardioblast (sensu Arthropoda) namespace: cell xref: FBbt:00001666 is_a: CL:0010021 ! cardiac myoblast [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell namespace: cell alt_id: CL:0000640 def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl] synonym: "ACTH secreting cell" EXACT [GO:0051458] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [GO:0051458] is_a: CL:0000163 ! endocrine cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0051458 ! corticotropin secretion relationship: capable_of GO:0051458 ! corticotropin secretion [Term] id: CL:0000468 name: neuroglioblast namespace: cell xref: FBbt:00005147 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000469 name: ganglion mother cell namespace: cell xref: FBbt:00005149 is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000470 name: digestive enzyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000472 name: obsolete chlorenchyma cell namespace: cell def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208] comment: replaced_by: PO:0000076 is_obsolete: true [Term] id: CL:0000473 name: defensive cell namespace: cell def: "A cell whose primary function is to protect the organism." [JB:jb] is_a: CL:0000003 ! native cell [Term] id: CL:0000474 name: pericardial nephrocyte namespace: cell def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [FBbt:00003184, GO:0061320, GOC:tfm, PMID:19783135] synonym: "pericardial cell" NARROW [FBbt:00005058, GO:0061320] xref: FBbt:00005058 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000475 name: obsolete degenerate megaspore namespace: cell def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr] comment: replaced_by: PO:0000245 is_obsolete: true [Term] id: CL:0000476 name: thyrotroph namespace: cell def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis relationship: capable_of GO:0070460 ! thyroid-stimulating hormone secretion [Term] id: CL:0000477 name: follicle cell namespace: cell comment: Editors note: check this. Currently used in goxp synonym: "ovarian follicle cell" EXACT [GO:0007297] xref: FBbt:00004904 is_a: CL:0000075 ! columnar/cuboidal epithelial cell relationship: develops_from CL:0000441 ! follicle stem cell [Term] id: CL:0000478 name: oxytocin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000479 name: vasopressin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000480 name: secretin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000481 name: cholecystokin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000482 name: juvenile hormone secreting cell namespace: cell def: "An endocrine cell that secretes juvenile hormone." [GO:tfm] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0045443 ! juvenile hormone secretion relationship: capable_of GO:0045443 ! juvenile hormone secretion [Term] id: CL:0000483 name: bombesin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000484 name: connective tissue type mast cell namespace: cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000097 ! mast cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue [Term] id: CL:0000485 name: mucosal type mast cell namespace: cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell intersection_of: CL:0000097 ! mast cell intersection_of: capable_of GO:0002540 ! leukotriene production involved in inflammatory response intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: capable_of GO:0002540 ! leukotriene production involved in inflammatory response relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000486 name: garland cell namespace: cell def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [fbbt:00005059, GOC:tfm, PMID:19783135] synonym: "garland nephrocyte" BROAD [GO:0061321] xref: BTO:0004596 xref: FBbt:00005059 is_a: CL:0000227 ! binucleate cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000487 name: oenocyte namespace: cell def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397] xref: FBbt:00004995 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000488 name: visible light photoreceptor cell namespace: cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: capable_of GO:0009584 ! detection of visible light relationship: capable_of GO:0009584 ! detection of visible light [Term] id: CL:0000489 name: scotopic photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000490 name: photopic photoreceptor cell namespace: cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000491 name: obsolete cytotoxic T cell namespace: cell def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." [] comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. is_obsolete: true [Term] id: CL:0000492 name: CD4-positive helper T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A11.118.637.555.567.569.200.400] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0001816 ! cytokine production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation [Term] id: CL:0000493 name: obsolete regulatory T cell namespace: cell def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." [] comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. is_obsolete: true [Term] id: CL:0000494 name: UV sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that detects ultraviolet light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: capable_of GO:0009589 ! detection of UV relationship: capable_of GO:0009589 ! detection of UV [Term] id: CL:0000495 name: blue sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to blue light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000496 name: green sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to green light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000497 name: red sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to red light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000498 name: inhibitory interneuron namespace: cell def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron] xref: FMA:84776 is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell namespace: cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A11.329.830] xref: BTO:0002064 xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000500 name: follicular epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000501 name: granulosa cell namespace: cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A05.360.319.114.630.535.200] synonym: "granulosa cell of ovary" EXACT [] xref: BTO:0000542 xref: CALOHA:TS-0729 xref: FMA:18718 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary [Term] id: CL:0000502 name: type D enteroendocrine cell namespace: cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A03.492.766.440.175] synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell relationship: capable_of GO:0070253 ! somatostatin secretion [Term] id: CL:0000503 name: theca cell namespace: cell def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A05.360.319.114.630.535.400] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000499 ! stromal cell is_a: CL:0000593 ! androgen secreting cell [Term] id: CL:0000504 name: enterochromaffin-like cell namespace: cell def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:A06.224.365] comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. synonym: "ECL" EXACT [] xref: BTO:0002692 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell [Term] id: CL:0000505 name: substance P secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes substance P." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell namespace: cell def: "An endorphine cell that secretes enkephalin." [GO:tfm] is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell namespace: cell def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A03.492.766.440.300] synonym: "G cell " EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum [Term] id: CL:0000509 name: gastrin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000510 name: paneth cell namespace: cell def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A03.492.411.369.700] xref: BTO:0000993 xref: FMA:62897 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0000323 ! lysozyme secreting cell relationship: part_of UBERON:0001277 ! intestinal epithelium [Term] id: CL:0000511 name: androgen binding protein secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm] is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000512 name: paracrine cell namespace: cell def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [GOC:tfm, ISBN:0198529171] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000513 name: cardiac muscle myoblast namespace: cell alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A11.635.470] xref: FMA:84797 is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue relationship: develops_into CL:0000746 ! cardiac muscle cell relationship: part_of UBERON:0001133 ! cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast namespace: cell def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A11.635.510, MESH:D032390] synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 {is_inferred="true"} ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000192 ! smooth muscle cell relationship: develops_into CL:0000192 ! smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast namespace: cell def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 {is_inferred="true"} ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell relationship: develops_into CL:0008002 ! skeletal muscle fiber [Term] id: CL:0000516 name: perineuronal satellite cell namespace: cell def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:A08.340.685] synonym: "perineural satellite cell" EXACT [] synonym: "perineuronal satellite oligodendroglial cell" EXACT [] synonym: "satellite oligodendrocyte" EXACT [] xref: FMA:54550 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000517 name: macrophage derived foam cell namespace: cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) namespace: cell def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) namespace: cell def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [GOC:tfm] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000520 name: prokaryotic cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000521 name: fungal cell namespace: cell is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000548 ! animal cell [Term] id: CL:0000522 name: obsolete spore namespace: cell def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000523 name: mononuclear cytotrophoblast cell namespace: cell def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908] synonym: "Langhans' cell" EXACT [] xref: FMA:83042 is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000524 name: spheroplast namespace: cell def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A11.868] synonym: "sphaeroplast" EXACT [] is_a: CL:0000371 ! protoplast [Term] id: CL:0000525 name: syncytiotrophoblast cell namespace: cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] synonym: "plasmidotrophoblast" EXACT [] synonym: "syncytial trophoblast" EXACT [] synonym: "syntrophoblast" EXACT [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000526 name: afferent neuron namespace: cell def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A08.663.650] synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000540 ! neuron [Term] id: CL:0000527 name: efferent neuron namespace: cell def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A08.663.655] synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000528 name: nitrergic neuron namespace: cell def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:A08.663.748] xref: FMA:84792 is_a: CL:0000540 ! neuron [Term] id: CL:0000529 name: pigmented epithelial cell namespace: cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000531 name: primary sensory neuron namespace: cell is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: CL:0000530 ! primary neuron [Term] id: CL:0000532 name: CAP motoneuron namespace: cell is_a: CL:0000533 ! primary motor neuron [Term] id: CL:0000533 name: primary motor neuron namespace: cell xref: FMA:83619 is_a: CL:0000100 ! motor neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000534 name: primary interneuron namespace: cell is_a: CL:0000099 ! interneuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000535 name: secondary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000536 name: secondary motor neuron namespace: cell xref: FMA:83620 is_a: CL:0000100 ! motor neuron is_a: CL:0000535 ! secondary neuron intersection_of: CL:0000100 ! motor neuron intersection_of: CL:0000535 ! secondary neuron [Term] id: CL:0000537 name: obsolete antipodal cell namespace: cell def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208] comment: replaced_by: PO:0020093 is_obsolete: true [Term] id: CL:0000538 name: obsolete epidermal initial namespace: cell def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr] comment: replaced_by: PO:0000349 is_obsolete: true [Term] id: CL:0000539 name: obsolete idioblast namespace: cell def: "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000540 name: neuron namespace: cell def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:A08.663, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FBbt:00005106 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000000 ! cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: capable_of GO:0019226 ! transmission of nerve impulse relationship: develops_from CL:0000031 ! neuroblast [Term] id: CL:0000541 name: melanoblast namespace: cell def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl] comment: Derived from UBERON:0002342 neural crest. xref: BTO:0003217 xref: FMA:83377 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000542 name: lymphocyte namespace: cell def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: VHOG:0001535 is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000738 ! leukocyte intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: lacks_part GO:0030141 ! secretory granule disjoint_from: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0000792 ! heterochromatin relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000543 name: obsolete sieve tube member namespace: cell def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208] comment: replaced_by: PO:0000289 synonym: "sieve tube element" EXACT [] is_obsolete: true [Term] id: CL:0000544 name: slowly adapting mechanoreceptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000545 name: T-helper 1 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [PMID:9419219] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 CD4+ T cell" EXACT [PMID:22343568] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: BTO:0001678 xref: FMA:84382 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21 intersection_of: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: capable_of GO:0032609 ! interferon-gamma production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001835 ! T-box transcription factor TBX21 relationship: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 [Term] id: CL:0000546 name: T-helper 2 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [PMID:9419219] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: capable_of GO:0032633 ! interleukin-4 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0000547 name: proerythroblast namespace: cell def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A11.118.290.350.200, PMID:1638021] synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0005634 ! nucleus intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: develops_from CL:0000038 ! erythroid progenitor cell relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0005634 ! nucleus relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G [Term] id: CL:0000548 name: animal cell namespace: cell subset: ubprop:upper_level is_a: CL:0000255 ! eukaryotic cell relationship: has_part GO:0005902 ! microvillus [Term] id: CL:0000549 name: basophilic erythroblast namespace: cell def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000550 name: polychromatophilic erythroblast namespace: cell def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000035 ! polychromatophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000549 ! basophilic erythroblast relationship: has_part CP:0000035 ! polychromatophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000551 name: unimodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000552 name: orthochromatic erythroblast namespace: cell def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation relationship: develops_from CL:0000550 ! polychromatophilic erythroblast relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: participates_in GO:0030263 ! apoptotic chromosome condensation [Term] id: CL:0000553 name: megakaryocyte progenitor cell namespace: cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0007113 ! endomitotic cell cycle intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: capable_of GO:0007113 ! endomitotic cell cycle relationship: capable_of GO:0030219 ! megakaryocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000554 name: gastrin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000555 name: neuronal brush cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000556 name: megakaryocyte namespace: cell def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 {is_inferred="true"} ! myeloid cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001393 ! euploid intersection_of: part_of UBERON:0002371 ! bone marrow disjoint_from: CL:0000764 ! erythroid lineage cell relationship: bearer_of PATO:0001393 ! euploid relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell relationship: part_of UBERON:0002371 ! bone marrow [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] synonym: "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:0011115 ! precursor cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030225 ! macrophage differentiation intersection_of: capable_of GO:0030851 ! granulocyte differentiation intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_part PR:000007857 ! erythroid transcription factor intersection_of: lacks_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: part_of UBERON:0002371 ! bone marrow relationship: capable_of GO:0030225 ! macrophage differentiation relationship: capable_of GO:0030851 ! granulocyte differentiation relationship: develops_from CL:0000049 ! common myeloid progenitor relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_part PR:000007857 ! erythroid transcription factor relationship: lacks_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: part_of UBERON:0002371 ! bone marrow [Term] id: CL:0000558 name: reticulocyte namespace: cell def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] xref: BTO:0001173 xref: CALOHA:TS-0864 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0071971 ! extracellular exosome assembly intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: capable_of GO:0071971 ! extracellular exosome assembly relationship: develops_from CL:0000552 ! orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G [Term] id: CL:0000559 name: promonocyte namespace: cell def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. xref: BTO:0004657 xref: FMA:83551 is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: capable_of GO:0030224 ! monocyte differentiation intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: capable_of GO:0030224 ! monocyte differentiation relationship: develops_from CL:0000040 ! monoblast relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000560 name: band form neutrophil namespace: cell def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: Found in the Band 1 fraction. synonym: "band" BROAD [] synonym: "band cell" BROAD [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" BROAD [] is_a: CL:0000096 {is_inferred="true"} ! mature neutrophil intersection_of: CL:0000096 ! mature neutrophil intersection_of: has_part CP:0000039 ! banded nucleus intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001337 ! complement receptor type 1 intersection_of: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein intersection_of: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4 intersection_of: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007597 ! proto-oncogene c-Fos relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001337 ! complement receptor type 1 relationship: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010799 ! myb proto-oncogene protein relationship: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4 relationship: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase [Term] id: CL:0000561 name: amacrine cell namespace: cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:A08.663.358.050] comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748). synonym: "amacrine neuron" EXACT [] xref: BTO:0004044 xref: FBbt:00005127 xref: FMA:67766 is_a: CL:0000099 ! interneuron [Term] id: CL:0000562 name: nucleate erythrocyte namespace: cell def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 {is_inferred="true"} ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: has_part GO:0005634 ! nucleus relationship: develops_from CL:0002421 ! nucleated reticulocyte relationship: has_part GO:0005634 ! nucleus [Term] id: CL:0000563 name: endospore namespace: cell def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [GOC:tfm, ISBN:0618947256] synonym: "bacterial spore" EXACT [] xref: BTO:0002779 is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte namespace: cell def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] xref: FMA:84196 is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: capable_of GO:0030223 ! neutrophil differentiation intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_part PR:000014362 ! runt-related transcription factor 1 intersection_of: lacks_part PR:000009978 ! lactotransferrin relationship: capable_of GO:0030223 ! neutrophil differentiation relationship: develops_from CL:0000042 ! neutrophilic myeloblast relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_part PR:000014362 ! runt-related transcription factor 1 relationship: lacks_part PR:000009978 ! lactotransferrin [Term] id: CL:0000565 name: fat body cell namespace: cell def: "A cell found in fat bodies whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000181 ! metabolising cell [Term] id: CL:0000566 name: angioblastic mesenchymal cell namespace: cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: has_plasma_membrane_part PR:000001444 ! cadherin-5 intersection_of: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 relationship: develops_from CL:0000134 ! mesenchymal stem cell relationship: has_plasma_membrane_part PR:000001444 ! cadherin-5 relationship: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 relationship: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 [Term] id: CL:0000567 name: polymodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: APUD cell namespace: cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544, MESH:A11.070] synonym: "amine precursor uptake and decarboxylation cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell namespace: cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] is_a: CL:0008019 ! mesenchymal cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: develops_into CL:0002494 ! cardiocyte relationship: develops_into CL:0002494 ! cardiocyte [Term] id: CL:0000570 name: parafollicular cell namespace: cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." [GOC:tfm, ISBN:0517223651] synonym: "C cell" EXACT [] synonym: "C cell of thyroid gland" EXACT [FMA:68653] synonym: "clear cell of thyroid gland" EXACT [FMA:68653] synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653] synonym: "thyroid parafollicular cell" EXACT [FMA:68653] xref: FMA:68653 xref: SCTID:176770005 is_a: CL:0000443 {is_inferred="true"} ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: capable_of GO:0001820 ! serotonin secretion intersection_of: capable_of GO:0014046 ! dopamine secretion intersection_of: capable_of GO:0036161 ! calcitonin secretion intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: capable_of GO:0001820 ! serotonin secretion relationship: capable_of GO:0014046 ! dopamine secretion relationship: capable_of GO:0036161 ! calcitonin secretion relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland [Term] id: CL:0000571 name: leucophore namespace: cell def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005003 ! leucoblast [Term] id: CL:0000573 name: retinal cone cell namespace: cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A08.663.650.650.670.100] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000574 name: erythrophore namespace: cell def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005004 ! pigment erythroblast [Term] id: CL:0000575 name: corneal epithelial cell namespace: cell alt_id: CL:1000431 def: "An epithelial cell of the cornea." [GOC:tfm] synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: CL:0000576 name: monocyte namespace: cell def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:A11.118.637.555.652] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0011115 ! precursor cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: capable_of GO:0030225 ! macrophage differentiation intersection_of: capable_of GO:0030316 ! osteoclast differentiation intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation intersection_of: lacks_part GO:0030141 ! secretory granule relationship: capable_of GO:0030225 ! macrophage differentiation relationship: capable_of GO:0030316 ! osteoclast differentiation relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation relationship: develops_from CL:0000559 ! promonocyte relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000577 name: type EC enteroendocrine cell namespace: cell alt_id: CL:0002065 def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [MESH:A03.492.766.440.250, PMID:9505449] synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 xref: FMA:83132 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000506 ! enkephalin secreting cell relationship: part_of UBERON:0004786 ! gastrointestinal system mucosa [Term] id: CL:0000578 name: experimentally modified cell in vitro namespace: cell def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." [FB:ma, ReO:mhb] comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12 is_a: CL:0001034 ! cell in vitro [Term] id: CL:0000579 name: border follicle cell namespace: cell xref: FBbt:00004905 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000580 name: neutrophilic myelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. xref: BTO:0003455 xref: FMA:83540 is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: has_part PR:000009978 ! lactotransferrin intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part GO:0042582 ! azurophil granule relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000581 name: peritoneal macrophage namespace: cell def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:A11.329.372.630, PMID:15771589, PMID:19201820] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: BTO:0001034 xref: FMA:83025 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: capable_of GO:0042742 ! defense response to bacterium intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: RO:0001025 UBERON:0001179 ! peritoneal cavity relationship: capable_of GO:0042742 ! defense response to bacterium relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity [Term] id: CL:0000582 name: neutrophilic metamyelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: has_part PR:000009978 ! lactotransferrin intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor relationship: develops_from CL:0000580 ! neutrophilic myelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor [Term] id: CL:0000583 name: alveolar macrophage namespace: cell def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:A11.329.372.600] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] xref: BTO:0000802 xref: CALOHA:TS-0030 xref: FMA:83023 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: capable_of GO:0019882 ! antigen processing and presentation intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: RO:0001025 UBERON:0002299 ! alveolus of lung relationship: capable_of GO:0019882 ! antigen processing and presentation relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: RO:0001025 UBERON:0002299 ! alveolus of lung [Term] id: CL:0000584 name: enterocyte namespace: cell def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl] xref: BTO:0000398 xref: FMA:62122 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell [Term] id: CL:0000585 name: obsolete null cell namespace: cell def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." [] comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. is_obsolete: true [Term] id: CL:0000586 name: germ cell namespace: cell def: "The reproductive cell in multicellular organisms." [MESH:A05.360.490] xref: BTO:0000535 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell relationship: capable_of GO:0048609 ! multicellular organismal reproductive process [Term] id: CL:0000587 name: cold sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast namespace: cell def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A11.329.679] xref: BTO:0002516 xref: FMA:83027 is_a: CL:0000092 {is_inferred="true"} ! osteoclast intersection_of: CL:0000092 ! osteoclast intersection_of: capable_of GO:0042483 ! negative regulation of odontogenesis relationship: capable_of GO:0042483 ! negative regulation of odontogenesis [Term] id: CL:0000589 name: cochlear inner hair cell namespace: cell def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A08.663.650.250.250] synonym: "inner hair cell" BROAD [] xref: BTO:0003667 xref: FMA:62365 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000590 name: small luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400] synonym: "small lutein cell" EXACT [] synonym: "theca lutein cell" EXACT [] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000175 ! luteal cell relationship: develops_from CL:0000503 ! theca cell [Term] id: CL:0000591 name: warmth sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000592 name: large luteal cell namespace: cell def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400] synonym: "granulosa lutein cell" EXACT [] synonym: "granulosoluteocytus" RELATED [] xref: FMA:18689 is_a: CL:0000175 ! luteal cell is_a: CL:0000177 ! testosterone secreting cell relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000593 name: androgen secreting cell namespace: cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035935 ! androgen secretion relationship: capable_of GO:0035935 ! androgen secretion [Term] id: CL:0000594 name: skeletal muscle satellite cell namespace: cell def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [GOC:tfm, MESH:A11.635.500.700, PMID:21849021, PMID:23303905] comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population. is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000680 ! muscle precursor cell relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000595 name: enucleate erythrocyte namespace: cell def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 {is_inferred="true"} ! erythrocyte intersection_of: CL:0000232 ! erythrocyte intersection_of: bearer_of PATO:0001405 ! anucleate relationship: bearer_of PATO:0001405 ! anucleate relationship: develops_from CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000596 name: sexual spore namespace: cell def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000597 name: microconidium namespace: cell def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [GOC:tfm, ISBN:0471940526, PMID:8357339, SGD:clt] xref: FAO:0000028 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0000598 name: pyramidal neuron namespace: cell def: "Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:A08.186.211.577.405.700] synonym: "projection neuron" EXACT [] synonym: "pyramidal cell" EXACT [] synonym: "pyramidal neuron" EXACT [] xref: BTO:0003102 xref: FMA:67310 xref: FMA:86775 xref: NIFSTD:sao862606388 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000599 name: conidium namespace: cell def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [ISBN:08199377X, PMID:2524423, PMID:9529886, SGD:clt] xref: BTO:0000283 xref: FAO:0000024 is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000600 name: heterokaryon namespace: cell def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000521 ! fungal cell [Term] id: CL:0000601 name: outer hair cell namespace: cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A08.663.650.250.315] synonym: "cochlear outer hair cell" EXACT [] xref: BTO:0003666 xref: FMA:62366 is_a: CL:0000202 ! auditory hair cell relationship: part_of UBERON:0002227 ! spiral organ of cochlea [Term] id: CL:0000602 name: pressoreceptor cell namespace: cell def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A08.800.050.800.900.700] is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000603 name: dikaryon namespace: cell def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X] is_a: CL:0000227 ! binucleate cell is_a: CL:0000600 ! heterokaryon [Term] id: CL:0000604 name: retinal rod cell namespace: cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A08.663.650.650.670.650] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000605 name: fungal asexual spore namespace: cell def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium namespace: cell def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [GOC:tfm, ISBN:0471940526, SGD:clt] xref: FAO:0000038 is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore namespace: cell def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [GOC:tfm, ISBN:08199377X, SGD:clt] xref: BTO:0000097 xref: FAO:0000020 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore namespace: cell def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [ISBN:0471940526, ISBN:08199377X, SGD:clt] xref: FAO:0000040 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell namespace: cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:A08.663.650.250.380] synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! ear hair cell [Term] id: CL:0000610 name: obsolete plant cell namespace: cell comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO) is_obsolete: true consider: PO:0009002 [Term] id: CL:0000611 name: eosinophil progenitor cell namespace: cell comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). synonym: "CFU-Eo" RELATED [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" EXACT [PMCID:PMC2212039, PMCID:PMC2626675] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: capable_of GO:0030222 ! eosinophil differentiation intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: capable_of GO:0030222 ! eosinophil differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000612 name: eosinophilic myelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [GOC:add, GOC:dsd, http://www.cap.org, ISBN:0721601464, PMID:19622087] xref: BTO:0003454 xref: FMA:83542 is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000613 name: basophil progenitor cell namespace: cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1312421] comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: capable_of GO:0030221 ! basophil differentiation intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: capable_of GO:0030221 ! basophil differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000614 name: basophilic myelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030] xref: BTO:0003456 xref: FMA:83543 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000768 ! immature basophil intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0005730 ! nucleolus intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0005730 ! nucleolus relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000615 name: basidiospore namespace: cell def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [GOC:clt, ISBN:0471940526, ISBN:08199377X] xref: BTO:0002166 xref: FAO:0000021 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000616 name: obsolete sporangiospore namespace: cell def: "OBSOLETE: A walled spore produced in a sporangium." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000617 name: GABAergic neuron namespace: cell def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 xref: WBbt:0005190 is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0000618 name: sheath cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000619 name: support cell (sensu Nematoda) namespace: cell is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia) is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000620 name: obsolete zoospore namespace: cell def: "OBSOLETE: A sporangiospore that is motile, having flagella." [ISBN:08199377X] xref: FAO:0000039 is_obsolete: true [Term] id: CL:0000621 name: fusion competent myoblast namespace: cell def: "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." [PMID:22274696] is_a: CL:0008018 ! somatic muscle myoblast relationship: develops_into CL:0008003 ! somatic muscle myotube [Term] id: CL:0000622 name: acinar cell namespace: cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell relationship: part_of UBERON:0009842 ! glandular acinus [Term] id: CL:0000623 name: natural killer cell namespace: cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: BTO:0000914 xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 xref: VHOG:0001697 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: capable_of GO:0002228 ! natural killer cell mediated immunity intersection_of: capable_of GO:0050776 ! regulation of immune response intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: capable_of GO:0002228 ! natural killer cell mediated immunity relationship: capable_of GO:0050776 ! regulation of immune response relationship: develops_from CL:0000825 ! pro-NK cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell namespace: cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell namespace: cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000626 name: olfactory granule cell namespace: cell def: "Granule cell that is part of the olfactory bulb." [GOC:mah] is_a: CL:0000120 ! granule cell intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0002264 ! olfactory bulb [Term] id: CL:0000627 name: transporting cell namespace: cell def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr] is_a: CL:0000003 ! native cell [Term] id: CL:0000628 name: photosynthetic cell namespace: cell def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr] comment: see PMID:21177950, The making of a photosynthetic animal. is_a: CL:0000003 ! native cell [Term] id: CL:0000629 name: storage cell namespace: cell def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000630 name: supportive cell namespace: cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] xref: BTO:0002315 is_a: CL:0000003 ! native cell [Term] id: CL:0000631 name: labyrinth supporting cell namespace: cell def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:A09.246.631.246.577.543] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000632 name: hepatic stellate cell namespace: cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. synonym: "fat-storing cell" RELATED [] synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "Ito cell" EXACT [] synonym: "lipocyte" RELATED [] synonym: "perisinusoidal cell" EXACT [] synonym: "vitamin A-storing cells" RELATED [PMID:12808230] xref: BTO:0002741 xref: CALOHA:TS-0452 xref: FMA:67763 is_a: CL:0000057 ! fibroblast is_a: CL:0000152 ! exocrine cell is_a: CL:0000327 ! extracellular matrix secreting cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein intersection_of: part_of UBERON:0002107 ! liver relationship: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000633 name: Hensen cell namespace: cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Hensen" EXACT [] synonym: "external limiting cell of organ of Corti" EXACT [] synonym: "Hensen's cell" EXACT [] xref: FMA:79799 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:0000634 name: Claudius cell namespace: cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Claudius" EXACT [] synonym: "external supporting cell of Claudius" EXACT [] synonym: "external supporting cell of vestibular epithelium" EXACT [] xref: FMA:79802 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell namespace: cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544] synonym: "Deiters cell" EXACT [] synonym: "outer phalangeal cell" EXACT [] xref: FMA:75725 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0000636 name: Mueller cell namespace: cell xref: BTO:0003064 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland namespace: cell def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256] xref: FMA:83089 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002196 ! adenohypophysis relationship: capable_of GO:0030072 ! peptide hormone secretion relationship: part_of UBERON:0002196 ! adenohypophysis [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis namespace: cell def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis namespace: cell def: "A basophillic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] synonym: "pituitary beta cell" RELATED [] xref: FMA:83094 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000641 name: chromophobe cell namespace: cell def: "A cell that is resistant to stains." [GOC:tfm] synonym: "chromophobic cell" EXACT [] xref: FMA:83626 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000642 name: folliculostellate cell namespace: cell def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb] is_a: CL:0000163 ! endocrine cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000644 name: Bergmann glial cell namespace: cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000645 name: pituicyte namespace: cell def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651] xref: BTO:0003793 xref: FMA:83503 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000646 name: basal cell namespace: cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, ISBN:0517223651] xref: BTO:0000939 xref: FMA:62516 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000647 name: multinucleated giant cell namespace: cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:0702024783] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] xref: BTO:0003107 xref: FMA:83035 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: participates_in GO:0002432 ! granuloma formation intersection_of: participates_in GO:0002544 ! chronic inflammatory response relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000235 ! macrophage relationship: participates_in GO:0002432 ! granuloma formation relationship: participates_in GO:0002544 ! chronic inflammatory response [Term] id: CL:0000648 name: kidney granular cell namespace: cell alt_id: CL:0000461 def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727] synonym: "JG cell" EXACT [] synonym: "juxtaglomerular cell" BROAD [] synonym: "renin secreting cell" EXACT [] xref: FMA:84138 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000497 ! kidney cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0002001 ! renin secretion into blood stream intersection_of: part_of UBERON:0002113 ! kidney relationship: capable_of GO:0002001 ! renin secretion into blood stream relationship: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus [Term] id: CL:0000649 name: prickle cell namespace: cell alt_id: CL:0002186 def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." [GOC:tfm, ISBN:0721662544, ISBN:0815332181] synonym: "prickle cell of epidermis" EXACT [] xref: FMA:69059 is_a: CL:0000312 ! keratinocyte relationship: part_of UBERON:0002026 ! stratum spinosum of epidermis [Term] id: CL:0000650 name: mesangial cell namespace: cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells] comment: Do all of these cells really develop from some mesenchymal stem cell? synonym: "kidney mesangial cell" EXACT [] xref: BTO:0000853 xref: CALOHA:TS-0617 xref: FMA:70972 is_a: CL:0000669 ! pericyte cell relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000651 name: mucous neck cell namespace: cell def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm] synonym: "neck cell" BROAD [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: capable_of GO:0070254 ! mucus secretion [Term] id: CL:0000652 name: pinealocyte namespace: cell def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276] xref: BTO:0001068 xref: FMA:83417 is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: capable_of GO:0030187 ! melatonin biosynthetic process relationship: part_of UBERON:0001905 ! pineal body [Term] id: CL:0000653 name: glomerular visceral epithelial cell namespace: cell def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:tfm] comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967] synonym: "glomerular podocyte" EXACT [FMA:70967] synonym: "podocyte" EXACT [] xref: BTO:0002295 is_a: CL:0002518 ! kidney epithelial cell is_a: CL:0002522 ! renal filtration cell is_a: CL:1000451 ! epithelial cell of visceral layer of glomerular capsule relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule [Term] id: CL:0000654 name: primary oocyte namespace: cell def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544] synonym: "primary oogonium" RELATED [] xref: BTO:0000512 xref: FMA:18645 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007126 ! meiotic nuclear division relationship: develops_from CL:0000024 ! oogonial cell relationship: has_not_completed GO:0007126 ! meiotic nuclear division [Term] id: CL:0000655 name: secondary oocyte namespace: cell def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544] synonym: "primary oogonium" RELATED [] xref: BTO:0003094 xref: FMA:18646 is_a: CL:0000654 ! primary oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007147 ! female meiosis II relationship: develops_from CL:0000654 ! primary oocyte relationship: has_not_completed GO:0007147 ! female meiosis II [Term] id: CL:0000656 name: primary spermatocyte namespace: cell def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544] xref: BTO:0001115 xref: CALOHA:TS-2194 xref: FMA:72292 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte intersection_of: CL:0000017 ! spermatocyte intersection_of: bearer_of PATO:0001394 ! diploid intersection_of: capable_of GO:0007140 ! male meiosis relationship: bearer_of PATO:0001394 ! diploid relationship: capable_of GO:0007140 ! male meiosis [Term] id: CL:0000657 name: secondary spermatocyte namespace: cell def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544] xref: BTO:0000709 xref: CALOHA:TS-2195 xref: FBbt:00004941 xref: FMA:72293 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte is_a: CL:0000413 ! haploid cell intersection_of: CL:0000017 ! spermatocyte intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: capable_of GO:0007142 ! male meiosis II relationship: bearer_of PATO:0001375 ! haploid relationship: capable_of GO:0007142 ! male meiosis II relationship: develops_from CL:0000656 ! primary spermatocyte [Term] id: CL:0000658 name: cuticle secreting cell namespace: cell def: "An epithelial cell that secretes cuticle." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000659 name: eggshell secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes eggshell." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000500 ! follicular epithelial cell [Term] id: CL:0000660 name: glycocalyx secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes glycocalyx." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000662 name: neuroglioblast (sensu Nematoda) namespace: cell is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000663 name: valve cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000664 name: closable valve cell namespace: cell is_a: CL:0000185 ! myoepithelial cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000665 name: permanently open valve cell namespace: cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000666 name: fenestrated cell namespace: cell synonym: "window cell" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000667 name: collagen secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000668 name: obsolete parenchymal cell namespace: cell def: "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [ISBN:0471245208] comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. xref: BTO:0002174 xref: FMA:84638 is_obsolete: true [Term] id: CL:0000669 name: pericyte cell namespace: cell alt_id: CL:0000184 def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907] comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. synonym: "adventitial cell" RELATED [] synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [PMID:17986482] synonym: "cell of Rouget" EXACT [] synonym: "pericyte" EXACT [] synonym: "pericyte of Rouget" EXACT [] xref: BTO:0002441 xref: FMA:63174 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000670 name: primordial germ cell namespace: cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 {is_inferred="true"} ! germ line cell is_a: CL:0000219 {is_inferred="true"} ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0048870 ! cell motility intersection_of: part_of UBERON:0000922 ! embryo relationship: capable_of GO:0048870 ! cell motility relationship: part_of UBERON:0000922 ! embryo [Term] id: CL:0000671 name: centripetally migrating follicle cell namespace: cell xref: FBbt:00004906 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000672 name: obsolete tracheary element namespace: cell def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." [ISBN:0471245208] comment: replaced_by: PO:0000290 is_obsolete: true [Term] id: CL:0000673 name: Kenyon cell namespace: cell is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia) [Term] id: CL:0000674 name: interfollicle cell namespace: cell synonym: "fly stalk cell" EXACT [] xref: FBbt:00004910 is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000675 name: female gamete namespace: cell def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000676 name: cap cell namespace: cell xref: BTO:0001033 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000677 name: gut absorptive cell namespace: cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb] is_a: CL:0000212 ! absorptive cell [Term] id: CL:0000678 name: commissural neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000679 name: glutamatergic neuron namespace: cell xref: WBbt:0006829 is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission [Term] id: CL:0000680 name: muscle precursor cell namespace: cell is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell intersection_of: GO:0005623 ! cell intersection_of: develops_into CL:0000187 ! muscle cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: develops_into CL:0000187 ! muscle cell [Term] id: CL:0000681 name: radial glial cell namespace: cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life. synonym: "forebrain radial glial cell" NARROW [] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000682 name: M cell of gut namespace: cell def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [GOC:jb, GOC:tfm] comment: Should double check and see if M cells are particular to a specific region. synonym: "M cell" BROAD [] synonym: "M-cell" EXACT [] synonym: "microfold cell" EXACT [] xref: BTO:0003600 xref: FMA:62929 is_a: CL:0000066 ! epithelial cell is_a: CL:0000473 ! defensive cell is_a: CL:0000627 ! transporting cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0003929 ! digestive tract epithelium [Term] id: CL:0000683 name: ependymoglial cell namespace: cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [http://neurolex.org/wiki/Category\:Ependymoglial_Cell, JB:jb] synonym: "ependymal astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000684 name: littoral cell of liver namespace: cell is_a: CL:0000077 ! mesothelial cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000685 name: obsolete meristematic cell namespace: cell def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010] comment: replaced_by: PO:0004010 is_obsolete: true [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell namespace: cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0033326 ! cerebrospinal fluid secretion relationship: capable_of GO:0033326 ! cerebrospinal fluid secretion relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000687 name: R1 photoreceptor cell namespace: cell synonym: "R1 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000688 name: perijunctional fibroblast namespace: cell def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb] is_a: CL:0000057 ! fibroblast is_a: CL:0000630 ! supportive cell [Term] id: CL:0000689 name: myoendocrine cell namespace: cell def: "A cell with both myofibrils and secretory granules." [JB:jb] is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000690 name: R2 photoreceptor cell namespace: cell synonym: "R2 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000691 name: stellate interneuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000692 name: terminal Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb, PMID:16136171] synonym: "Schwann cell" BROAD [] is_a: CL:0000630 ! supportive cell is_a: CL:0002376 ! non-myelinating Schwann cell [Term] id: CL:0000693 name: neuroglioform cell namespace: cell def: "A stellate interneuron having 7-10 dendrites that may branch." [JB:jb] synonym: "spiderweb cell" EXACT [] is_a: CL:0000691 ! stellate interneuron [Term] id: CL:0000694 name: R3 photoreceptor cell namespace: cell synonym: "R3 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000695 name: Cajal-Retzius cell namespace: cell def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000696 name: PP cell namespace: cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000697 name: R4 photoreceptor cell namespace: cell synonym: "R4 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000698 name: obsolete paraganglial cell namespace: cell is_obsolete: true [Term] id: CL:0000699 name: paraganglial type 1 cell namespace: cell def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." [GOC:tfm] is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000700 name: dopaminergic neuron namespace: cell def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill] synonym: "dopaminergic cell" EXACT [] xref: BTO:0004032 xref: FMA:84787 xref: WBbt:0006746 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061527 ! dopamine secretion, neurotransmission relationship: capable_of GO:0061527 ! dopamine secretion, neurotransmission [Term] id: CL:0000701 name: paraganglia type 2 cell namespace: cell def: "Supports paraganglial type 1 cell." [JB:jb] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000702 name: R5 photoreceptor cell namespace: cell synonym: "R5 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000703 name: sustentacular cell namespace: cell def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb] xref: BTO:0002315 is_a: CL:0000630 ! supportive cell [Term] id: CL:0000704 name: endothelial tip cell namespace: cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0000705 name: R6 photoreceptor cell namespace: cell synonym: "R6 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000706 name: choroid plexus epithelial cell namespace: cell alt_id: CL:1000430 def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000627 ! transporting cell intersection_of: CL:0000065 ! ependymal cell intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus [Term] id: CL:0000707 name: R7 photoreceptor cell namespace: cell synonym: "R7 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000494 ! UV sensitive photoreceptor cell [Term] id: CL:0000708 name: leptomeningeal cell namespace: cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb] synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier [Term] id: CL:0000709 name: R8 photoreceptor cell namespace: cell synonym: "R8 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000710 name: neurecto-epithelial cell namespace: cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000711 name: cumulus cell namespace: cell def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [GOC:tfm, http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells] xref: BTO:0002236 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002174 ! follicular cell of ovary relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000712 name: stratum granulosum cell namespace: cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000362 ! epidermal cell intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis relationship: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis [Term] id: CL:0000713 name: corona radiata cell namespace: cell is_a: CL:0000711 ! cumulus cell [Term] id: CL:0000715 name: embryonic crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000717 name: fusimotor neuron namespace: cell def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000718 name: compound eye cone cell namespace: cell synonym: "cone cell (sensu Endopterygota)" RELATED [] is_a: CL:0000306 ! crystallin accumulating cell relationship: part_of UBERON:0000018 ! compound eye [Term] id: CL:0000719 name: posterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000720 name: anterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000721 name: equatorial cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000722 name: cystoblast namespace: cell is_a: CL:0000586 ! germ cell [Term] id: CL:0000723 name: somatic stem cell namespace: cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000034 ! stem cell intersection_of: capable_of GO:0048103 ! somatic stem cell division relationship: capable_of GO:0048103 ! somatic stem cell division [Term] id: CL:0000724 name: heterocyst namespace: cell def: " A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma] xref: BTO:0000600 is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell namespace: cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0009399 ! nitrogen fixation relationship: capable_of GO:0009399 ! nitrogen fixation [Term] id: CL:0000726 name: chlamydospore namespace: cell def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [GOC:tfm, ISBN:085199377X] comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000727 name: primary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000728 name: secondary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000729 name: tertiary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000730 name: leading edge cell namespace: cell def: "A cell at the front of a migrating epithelial sheet." [MA:ma] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000731 name: urothelial cell namespace: cell def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [GOC:tfm, MA:ma] synonym: "bladder transitional cell" NARROW [] synonym: "transitional epithelial cell of urinary bladder" NARROW [] synonym: "urinary tract transitional epithelial cell" NARROW [] xref: FMA:84127 is_a: CL:0000244 {is_inferred="true"} ! transitional epithelial cell intersection_of: CL:0000244 ! transitional epithelial cell intersection_of: part_of UBERON:0000365 ! urothelium relationship: part_of UBERON:0000365 ! urothelium [Term] id: CL:0000732 name: amoeboid cell namespace: cell is_a: CL:0000219 ! motile cell [Term] id: CL:0000733 name: lymph gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000734 name: embryonic gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000735 name: lymph gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000736 name: embryonic gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000737 name: striated muscle cell namespace: cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001410 ! striated intersection_of: has_part GO:0030017 ! sarcomere disjoint_from: CL:0008000 ! non-striated muscle cell relationship: bearer_of PATO:0001410 ! striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000738 name: leukocyte namespace: cell def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] synonym: "immune cell" EXACT [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 is_a: CL:0000219 ! motile cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration relationship: capable_of GO:0001667 ! ameboidal-type cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: part_of UBERON:0002405 ! immune system [Term] id: CL:0000740 name: retinal ganglion cell namespace: cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" EXACT [] xref: BTO:0001800 xref: FMA:67765 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0009004 ! retinal cell relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0000741 name: spinal accessory motor neuron namespace: cell def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219] synonym: "SACMN" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000742 name: periarticular chondrocyte namespace: cell def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842] is_a: CL:1001607 ! articular chondrocyte relationship: part_of UBERON:0010996 ! articular cartilage of joint [Term] id: CL:0000743 name: hypertrophic chondrocyte namespace: cell def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [GO_REF:0000034, PMID:15951842] comment: is hypertrophic pathological or normal? and can it be described using a pato term? is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000744 name: columnar chondrocyte namespace: cell def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000745 name: retina horizontal cell namespace: cell def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433] synonym: "horizontal cell" EXACT [] xref: BTO:0004120 is_a: CL:0000099 ! interneuron relationship: part_of UBERON:0003902 ! retinal neural layer [Term] id: CL:0000746 name: cardiac muscle cell namespace: cell alt_id: FMA:83808 def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0007100 ! primary circulatory organ intersection_of: participates_in GO:0060047 ! heart contraction relationship: bearer_of PATO:0002478 ! transversely striated relationship: develops_from CL:0000513 ! cardiac muscle myoblast relationship: has_part GO:0030017 ! sarcomere relationship: part_of UBERON:0007100 ! primary circulatory organ relationship: participates_in GO:0060047 ! heart contraction [Term] id: CL:0000747 name: cyanophore namespace: cell def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl] synonym: "blue chromatophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005005 ! cyanoblast [Term] id: CL:0000748 name: retinal bipolar neuron namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000103 ! bipolar neuron is_a: CL:0009004 ! retinal cell intersection_of: CL:0000103 ! bipolar neuron intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0000749 name: ON-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000750 name: OFF-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000751 name: rod bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [GOC:tfm, PMID:14689473] xref: FMA:67750 is_a: CL:0000749 ! ON-bipolar cell [Term] id: CL:0000752 name: cone retinal bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000753 name: type 1 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473] synonym: "DB1 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000754 name: type 2 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1." [PMID:14689473] synonym: "FMB cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000755 name: type 3 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB2 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000756 name: type 4 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB3 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000757 name: type 5 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473] synonym: "DB4 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000758 name: type 6 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473] synonym: "DB5 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000759 name: type 7 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473] synonym: "IMB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000760 name: type 8 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473] synonym: "DB6 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000761 name: type 9 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473] synonym: "BB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000762 name: nucleated thrombocyte namespace: cell def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205] comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: capable_of GO:0007596 ! blood coagulation relationship: bearer_of PATO:0001407 ! mononucleate relationship: capable_of GO:0007596 ! blood coagulation relationship: develops_from CL:0000828 ! thromboblast [Term] id: CL:0000763 name: myeloid cell namespace: cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] xref: BTO:0001441 xref: CALOHA:TS-0647 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell namespace: cell alt_id: CL:0002156 def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell [Term] id: CL:0000765 name: erythroblast namespace: cell def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: has_part GO:0005634 ! nucleus intersection_of: lacks_part GO:0005730 ! nucleolus intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part GO:0005634 ! nucleus relationship: lacks_part GO:0005730 ! nucleolus relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G [Term] id: CL:0000766 name: myeloid leukocyte namespace: cell def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] is_a: CL:0000738 {is_inferred="true"} ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000129 xref: CALOHA:TS-0073 xref: FMA:62862 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_high_plasma_membrane_amount PR:000001255 ! C-C chemokine receptor type 3 intersection_of: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 intersection_of: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5 relationship: has_high_plasma_membrane_amount PR:000001255 ! C-C chemokine receptor type 3 relationship: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 relationship: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5 [Term] id: CL:0000768 name: immature basophil namespace: cell def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000767 ! basophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus [Term] id: CL:0000769 name: basophilic metamyelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [GOC:tfm, ISBN:0721601464, PMID:18466030] xref: FMA:84198 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: develops_from CL:0000614 ! basophilic myelocyte relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N [Term] id: CL:0000770 name: band form basophil namespace: cell def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, http://www.cap.org, ISBN:0721601464, PMID:18466030] is_a: CL:0000768 {is_inferred="true"} ! immature basophil intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000039 ! banded nucleus relationship: develops_from CL:0000769 ! basophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus [Term] id: CL:0000771 name: eosinophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_plasma_membrane_part PR:000001254 ! C-C chemokine receptor type 1 intersection_of: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000001254 ! C-C chemokine receptor type 1 relationship: has_plasma_membrane_part PR:000001255 ! C-C chemokine receptor type 3 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule [Term] id: CL:0000772 name: immature eosinophil namespace: cell def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000771 ! eosinophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus relationship: develops_from CL:0000833 ! eosinophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus [Term] id: CL:0000773 name: eosinophilic metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: develops_from CL:0000612 ! eosinophilic myelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N [Term] id: CL:0000774 name: band form eosinophil namespace: cell def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000039 ! banded nucleus relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus [Term] id: CL:0000775 name: neutrophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000776 name: immature neutrophil namespace: cell def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 {is_inferred="true"} ! neutrophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000775 ! neutrophil intersection_of: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: has_part http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 ! alobate nucleus [Term] id: CL:0000777 name: mesangial phagocyte namespace: cell def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: capable_of GO:0019882 ! antigen processing and presentation intersection_of: capable_of GO:0048771 ! tissue remodeling intersection_of: RO:0001025 UBERON:0002320 ! glomerular mesangium relationship: capable_of GO:0019882 ! antigen processing and presentation relationship: capable_of GO:0048771 ! tissue remodeling relationship: RO:0001025 UBERON:0002320 ! glomerular mesangium [Term] id: CL:0000778 name: mononuclear osteoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000226 ! single nucleate cell intersection_of: CL:0000092 ! osteoclast intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000779 name: multinuclear osteoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000092 ! osteoclast intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000781 ! mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000778 {is_inferred="true"} ! mononuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000782 name: myeloid dendritic cell namespace: cell def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: develops_from CL:0000763 ! myeloid cell intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0000576 ! monocyte relationship: develops_from CL:0000763 ! myeloid cell relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain [Term] id: CL:0000783 name: multinucleated phagocyte namespace: cell def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000784 name: plasmacytoid dendritic cell namespace: cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, GOC:dsd, PMCID:PMC2118448, PMCID:PMC538703, PMID:15549123, PMID:17332250, PMID:17850486, PMID:20304825] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] xref: BTO:0004625 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: capable_of GO:0032606 ! type I interferon production relationship: capable_of GO:0032606 ! type I interferon production relationship: develops_from CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000785 name: mature B cell namespace: cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, GOC:dsd, ISBN:0781735149] comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: capable_of GO:0042113 ! B cell activation intersection_of: has_completed GO:0002335 ! mature B cell differentiation disjoint_from: CL:0000816 ! immature B cell disjoint_from: CL:0000817 ! precursor B cell disjoint_from: CL:0000818 ! transitional stage B cell relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: capable_of GO:0042113 ! B cell activation relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_completed GO:0002335 ! mature B cell differentiation [Term] id: CL:0000786 name: plasma cell namespace: cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Plasma_cell, ISBN:0721601464, ISBN:0781735149, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20951740] comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell intersection_of: CL:0000946 ! antibody secreting cell intersection_of: has_part CP:0000043 ! cartwheel heterochromatin intersection_of: has_part GO:0005794 ! Golgi apparatus intersection_of: has_plasma_membrane_part PR:000001935 ! syndecan-1 intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: develops_from CL:0000980 ! plasmablast relationship: has_part CP:0000043 ! cartwheel heterochromatin relationship: has_part GO:0005794 ! Golgi apparatus relationship: has_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000787 name: memory B cell namespace: cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, http://en.wikipedia.org/wiki/Memory_B_cell, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_completed GO:0002344 ! B cell affinity maturation intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: has_completed GO:0002344 ! B cell affinity maturation relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 [Term] id: CL:0000788 name: naive B cell namespace: cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20933013, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_not_completed GO:0002344 ! B cell affinity maturation intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_not_completed GO:0002344 ! B cell affinity maturation relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule [Term] id: CL:0000789 name: alpha-beta T cell namespace: cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex disjoint_from: CL:0000798 ! gamma-delta T cell relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex [Term] id: CL:0000790 name: immature alpha-beta T cell namespace: cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000791 name: mature alpha-beta T cell namespace: cell def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000790 ! immature alpha-beta T cell relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" BROAD [PMID:22343568] xref: FMA:84070 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0050777 ! negative regulation of immune response intersection_of: has_low_plasma_membrane_amount PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: capable_of GO:0050777 ! negative regulation of immune response relationship: has_low_plasma_membrane_amount PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0002385 ! mucosal immune response intersection_of: RO:0001025 UBERON:0001277 ! intestinal epithelium relationship: capable_of GO:0002385 ! mucosal immune response relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: RO:0001025 UBERON:0001277 ! intestinal epithelium [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: capable_of GO:0001913 ! T cell mediated cytotoxicity intersection_of: capable_of GO:0033380 ! granzyme B localization to T cell secretory granule intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_part PR:000003466 ! perforin-1 intersection_of: has_part PR:000003499 ! granzyme B relationship: capable_of GO:0001913 ! T cell mediated cytotoxicity relationship: capable_of GO:0033380 ! granzyme B localization to T cell secretory granule relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_part PR:000003466 ! perforin-1 relationship: has_part PR:000003499 ! granzyme B [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: FMA:84070 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0050777 ! negative regulation of immune response [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell namespace: cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell namespace: cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: capable_of GO:0002385 ! mucosal immune response intersection_of: RO:0001025 UBERON:0001277 ! intestinal epithelium relationship: capable_of GO:0002385 ! mucosal immune response relationship: RO:0001025 UBERON:0001277 ! intestinal epithelium [Term] id: CL:0000798 name: gamma-delta T cell namespace: cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex [Term] id: CL:0000799 name: immature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_not_completed GO:0042492 ! gamma-delta T cell differentiation intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_not_completed GO:0042492 ! gamma-delta T cell differentiation relationship: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000800 name: mature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000799 ! immature gamma-delta T cell relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell namespace: cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: capable_of GO:0002385 ! mucosal immune response intersection_of: RO:0001025 UBERON:0001277 ! intestinal epithelium relationship: capable_of GO:0002385 ! mucosal immune response relationship: RO:0001025 UBERON:0001277 ! intestinal epithelium [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000805 name: immature single positive thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000808 ! DN4 thymocyte relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000806 name: DN2 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000807 name: DN3 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000806 ! DN2 thymocyte relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000808 name: DN4 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte namespace: cell def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Thymocytes of this stage are undergoing positive and negative selection. synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000805 ! immature single positive thymocyte relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000813 name: memory T cell namespace: cell def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] xref: BTO:0003435 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha disjoint_from: CL:0000898 ! naive T cell relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000814 name: mature NK T cell namespace: cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: capable_of GO:0032394 ! MHC class Ib receptor activity intersection_of: capable_of GO:0045087 ! innate immune response intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: capable_of GO:0032394 ! MHC class Ib receptor activity relationship: capable_of GO:0045087 ! innate immune response relationship: develops_from CL:0002042 ! immature NK T cell stage IV relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein [Term] id: CL:0000815 name: regulatory T cell namespace: cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: BTO:0004520 xref: FMA:84070 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0050777 ! negative regulation of immune response [Term] id: CL:0000816 name: immature B cell namespace: cell def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, GOC:tfm, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [ISBN:781735149] is_a: CL:0000236 ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_not_completed GO:0045190 ! isotype switching intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: develops_from CL:0000954 ! small pre-B-II cell relationship: has_not_completed GO:0045190 ! isotype switching relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000817 name: precursor B cell namespace: cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm] synonym: "pre-B cell" RELATED [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex disjoint_from: CL:0000826 ! pro-B cell relationship: has_plasma_membrane_part PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000818 name: transitional stage B cell namespace: cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional B cell" EXACT [PMID:22343568] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_not_completed GO:0002335 ! mature B cell differentiation intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: develops_from CL:0000816 ! immature B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_not_completed GO:0002335 ! mature B cell differentiation relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000819 name: B-1 B cell namespace: cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/B-1_cell, PMID:11861604, PMID:20933013, PMID:21220451] comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: capable_of GO:0045087 ! innate immune response intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: capable_of GO:0045087 ! innate immune response relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000820 name: B-1a B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000821 name: B-1b B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000822 name: B-2 B cell namespace: cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:11861604, PMID:20933013] comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000823 name: immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000623 {is_inferred="true"} ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: bearer_of PATO:0001501 ! immature disjoint_from: CL:0000824 ! mature natural killer cell disjoint_from: CL:0000937 ! pre-natural killer cell relationship: bearer_of PATO:0001501 ! immature relationship: develops_from CL:0000937 ! pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell namespace: cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782] synonym: "LAK cell" BROAD [PMID:14685782] synonym: "lymphokine activated killer cell" BROAD [PMID:14685782] synonym: "mature NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: develops_from CL:0000823 ! immature natural killer cell [Term] id: CL:0000825 name: pro-NK cell namespace: cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674] comment: Most markers only described for human pro NK cells. synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674] synonym: "null cell" RELATED [PMID:11532393] synonym: "preNK cell" RELATED [PMID:11532393] synonym: "pro-natural killer cell" EXACT [] is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor [Term] id: CL:0000826 name: pro-B cell namespace: cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, GOC:dsd, ISBN:0781735149, PMID:12633665, PMID:16551251, PMID:18432934] comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] synonym: "pre-pro B cell" BROAD [PMID:17582343] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] synonym: "progenitor B lymphocyte" EXACT [] synonym: "progenitor B-cell" EXACT [] synonym: "progenitor B-lymphocyte" EXACT [] xref: BTO:0003104 is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: has_part PR:000001903 ! paired box protein PAX-5 intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: participates_in GO:0033152 ! immunoglobulin V(D)J recombination relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part PR:000001903 ! paired box protein PAX-5 relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase relationship: participates_in GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: CL:0000827 name: pro-T cell namespace: cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: capable_of GO:0030217 ! T cell differentiation relationship: capable_of GO:0030217 ! T cell differentiation relationship: develops_from CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000828 name: thromboblast namespace: cell def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949] comment: Note that this is a non-mammalian cell type. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: capable_of GO:0002574 ! thrombocyte differentiation relationship: bearer_of PATO:0001407 ! mononucleate relationship: capable_of GO:0002574 ! thrombocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000829 name: basophilic myeloblast namespace: cell def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: capable_of GO:0030221 ! basophil differentiation relationship: capable_of GO:0030221 ! basophil differentiation relationship: develops_from CL:0000613 ! basophil progenitor cell [Term] id: CL:0000830 name: basophilic promyelocyte namespace: cell def: "A promyelocyte committed to the basophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84208 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: capable_of GO:0030221 ! basophil differentiation relationship: capable_of GO:0030221 ! basophil differentiation relationship: develops_from CL:0000829 ! basophilic myeloblast [Term] id: CL:0000831 name: mast cell progenitor namespace: cell def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1183570, PMCID:PMC1312421, PMID:8629001, PMID:9354811] comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. synonym: "CFU-Mast " RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0060374 ! mast cell differentiation intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: capable_of GO:0060374 ! mast cell differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000832 name: eosinophilic myeloblast namespace: cell def: "A myeloblast committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: capable_of GO:0030222 ! eosinophil differentiation relationship: capable_of GO:0030222 ! eosinophil differentiation relationship: develops_from CL:0000611 ! eosinophil progenitor cell [Term] id: CL:0000833 name: eosinophilic promyelocyte namespace: cell def: "A promyelocyte committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84199 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: capable_of GO:0030222 ! eosinophil differentiation relationship: capable_of GO:0030222 ! eosinophil differentiation relationship: develops_from CL:0000832 ! eosinophilic myeloblast [Term] id: CL:0000834 name: neutrophil progenitor cell namespace: cell def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: capable_of GO:0030223 ! neutrophil differentiation relationship: capable_of GO:0030223 ! neutrophil differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000835 name: myeloblast namespace: cell def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] xref: BTO:0000187 xref: FMA:83524 is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0000791 ! euchromatin intersection_of: lacks_part GO:0042582 ! azurophil granule relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0000791 ! euchromatin relationship: lacks_part GO:0042582 ! azurophil granule [Term] id: CL:0000836 name: promyelocyte namespace: cell def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [GOC:add, GOC:amm, GOC:tfm, http://www.cap.org, ISBN:0721601464] xref: CALOHA:TS-0825 xref: FMA:83530 is_a: CL:0002191 ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0000835 ! myeloblast relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0005730 ! nucleolus relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001402 ! multipotent intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: bearer_of PATO:0001402 ! multipotent relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "lymphoid progenitor cell" BROAD [] xref: BTO:0004731 xref: CALOHA:TS-2025 xref: FMA:70338 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: capable_of GO:0030098 ! lymphocyte differentiation disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: capable_of GO:0030098 ! lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: capable_of GO:0030099 ! myeloid cell differentiation relationship: capable_of GO:0030099 ! myeloid cell differentiation [Term] id: CL:0000840 name: immature conventional dendritic cell namespace: cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [GOC:add, GOC:tfm, PMID:9521319] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000841 name: mature conventional dendritic cell namespace: cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, GOC:tfm, PMID:9521319] synonym: "mature dendritic cell" BROAD [] {comment="GOC:add"} synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000840 ! immature conventional dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000842 name: mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: lacks_part GO:0030141 ! secretory granule relationship: bearer_of PATO:0001407 ! mononucleate relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000843 name: follicular B cell namespace: cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Follicular_B_Cells, ISBN:0781735149, PMCID:PMC2193793, PMID:20933013] comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor [Term] id: CL:0000844 name: germinal center B cell namespace: cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: part_of UBERON:0001745 ! secondary nodular lymphoid tissue relationship: develops_from CL:0000843 ! follicular B cell relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue [Term] id: CL:0000845 name: marginal zone B cell namespace: cell def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Marginal-zone_B_cell, ISBN:0781735149, PMID:10933592, PMID:20933013] comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. synonym: "marginal zone B lymphocyte" EXACT [] synonym: "marginal zone B-cell" EXACT [] synonym: "marginal zone B-lymphocyte" EXACT [] synonym: "MZ B cell" EXACT [] synonym: "MZ B lymphocyte" EXACT [] synonym: "MZ B-cell" EXACT [] synonym: "MZ B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: capable_of GO:0042742 ! defense response to bacterium intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: part_of UBERON:0001251 ! marginal zone of spleen relationship: capable_of GO:0042742 ! defense response to bacterium relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000846 name: vestibular dark cell namespace: cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000847 name: ciliated olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163] synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] is_a: CL:0000064 ! ciliated cell is_a: CL:0000207 ! olfactory receptor cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000848 name: microvillous olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163] synonym: "microvillous olfactory sensory neuron" EXACT [] synonym: "microvillous sensory neuron" RELATED [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000849 name: crypt olfactory receptor neuron namespace: cell def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163] synonym: "crypt cell" EXACT [] synonym: "crypt olfactory sensory neuron" EXACT [] synonym: "crypt sensory neuron" EXACT [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000850 name: serotonergic neuron namespace: cell alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: FBbt:00005133 xref: WBbt:0006837 is_a: CL:0000381 ! neurosecretory neuron is_a: CL:0000458 ! serotonin secreting cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission [Term] id: CL:0000851 name: neuromast mantle cell namespace: cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509] is_a: CL:0000151 ! secretory cell disjoint_from: CL:0000855 ! sensory hair cell relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000852 name: neuromast support cell namespace: cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509] is_a: CL:0000630 ! supportive cell disjoint_from: CL:0000855 ! sensory hair cell relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000853 name: olfactory epithelial support cell namespace: cell def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl] synonym: "olfactory sustentacular cell" EXACT [] synonym: "supporting cell of olfactory epithelium" EXACT [] synonym: "sustentaculocyte of olfactory epithelium" EXACT [] xref: FMA:62302 is_a: CL:0000630 ! supportive cell is_a: CL:0002169 ! basal cell of olfactory epithelium intersection_of: CL:0000630 ! supportive cell intersection_of: part_of UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0001997 ! olfactory epithelium [Term] id: CL:0000854 name: interneuromast cell namespace: cell def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl] is_a: CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000032 ! neuroplacodal cell [Term] id: CL:0000855 name: sensory hair cell namespace: cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl] synonym: "hair cell" BROAD [] xref: BTO:0004744 is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell namespace: cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl] is_a: CL:0000855 ! sensory hair cell intersection_of: CL:0000855 ! sensory hair cell intersection_of: part_of UBERON:0008904 ! neuromast relationship: part_of UBERON:0008904 ! neuromast [Term] id: CL:0000857 name: slow muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000189 ! slow muscle cell relationship: develops_into CL:0000189 ! slow muscle cell [Term] id: CL:0000858 name: fast muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000190 ! fast muscle cell relationship: develops_into CL:0000190 ! fast muscle cell [Term] id: CL:0000860 name: classical monocyte namespace: cell def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000234 ! phagocyte is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: capable_of GO:0002548 ! monocyte chemotaxis intersection_of: capable_of GO:0006909 ! phagocytosis intersection_of: capable_of GO:0006954 ! inflammatory response intersection_of: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: capable_of GO:0002548 ! monocyte chemotaxis relationship: capable_of GO:0006909 ! phagocytosis relationship: capable_of GO:0006954 ! inflammatory response relationship: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000861 name: elicited macrophage namespace: cell def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: participates_in GO:0006954 ! inflammatory response relationship: develops_from CL:0000860 ! classical monocyte relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: participates_in GO:0006954 ! inflammatory response [Term] id: CL:0000862 name: suppressor macrophage namespace: cell def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0050777 ! negative regulation of immune response [Term] id: CL:0000863 name: inflammatory macrophage namespace: cell def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana, PMID:19132917] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: capable_of GO:0032611 ! interleukin-1 beta production intersection_of: capable_of GO:0032635 ! interleukin-6 production intersection_of: capable_of GO:0032640 ! tumor necrosis factor production intersection_of: capable_of GO:0042554 ! superoxide anion generation intersection_of: capable_of GO:0042742 ! defense response to bacterium intersection_of: capable_of GO:0051767 ! nitric-oxide synthase biosynthetic process relationship: capable_of GO:0032611 ! interleukin-1 beta production relationship: capable_of GO:0032635 ! interleukin-6 production relationship: capable_of GO:0032640 ! tumor necrosis factor production relationship: capable_of GO:0042554 ! superoxide anion generation relationship: capable_of GO:0042742 ! defense response to bacterium relationship: capable_of GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: CL:0000864 name: tissue-resident macrophage namespace: cell def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0000479 ! tissue relationship: part_of UBERON:0000479 ! tissue [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine relationship: part_of UBERON:0001238 ! lamina propria of small intestine [Term] id: CL:0000866 name: thymic macrophage namespace: cell def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: capable_of GO:0043277 ! apoptotic cell clearance intersection_of: part_of UBERON:0002370 ! thymus relationship: capable_of GO:0043277 ! apoptotic cell clearance relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000867 name: secondary lymphoid organ macrophage namespace: cell def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865] comment: Marker was observed on rat cells. synonym: "MF.LN" EXACT [] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0000029 ! lymph node relationship: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0000029 ! lymph node [Term] id: CL:0000869 name: tonsillar macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue intersection_of: part_of UBERON:0002372 ! tonsil relationship: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue relationship: part_of UBERON:0002372 ! tonsil [Term] id: CL:0000870 name: Peyer's patch macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: CL:0000871 name: splenic macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage is_a: CL:2000074 ! splenocyte intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: capable_of GO:0034102 ! erythrocyte clearance intersection_of: part_of UBERON:0002106 ! spleen relationship: capable_of GO:0034102 ! erythrocyte clearance relationship: part_of UBERON:0002106 ! spleen [Term] id: CL:0000872 name: splenic marginal zone macrophage namespace: cell def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO intersection_of: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: part_of UBERON:0001251 ! marginal zone of spleen relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO relationship: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000873 name: splenic metallophillic macrophage namespace: cell def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: adjacent_to UBERON:0001959 ! white pulp of spleen intersection_of: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001251 ! marginal zone of spleen relationship: adjacent_to UBERON:0001959 ! white pulp of spleen relationship: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000874 name: splenic red pulp macrophage namespace: cell def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: capable_of GO:0006955 ! immune response intersection_of: capable_of GO:0034102 ! erythrocyte clearance intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: part_of UBERON:0001250 ! red pulp of spleen relationship: capable_of GO:0006955 ! immune response relationship: capable_of GO:0034102 ! erythrocyte clearance relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: part_of UBERON:0001250 ! red pulp of spleen [Term] id: CL:0000875 name: non-classical monocyte namespace: cell def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: bearer_of PATO:0000587 ! decreased size intersection_of: capable_of GO:0031294 ! lymphocyte costimulation intersection_of: has_completed GO:0030224 ! monocyte differentiation intersection_of: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: bearer_of PATO:0000587 ! decreased size relationship: capable_of GO:0031294 ! lymphocyte costimulation relationship: develops_from CL:0002393 ! intermediate monocyte relationship: has_completed GO:0030224 ! monocyte differentiation relationship: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000876 name: splenic white pulp macrophage namespace: cell def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597] comment: Markers: Mouse: F4/80-, CD68+, macrosialin+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001959 ! white pulp of spleen relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001959 ! white pulp of spleen [Term] id: CL:0000877 name: splenic tingible body macrophage namespace: cell def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000876 {is_inferred="true"} ! splenic white pulp macrophage intersection_of: CL:0000876 ! splenic white pulp macrophage intersection_of: capable_of GO:0043277 ! apoptotic cell clearance intersection_of: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer intersection_of: part_of UBERON:0001249 ! spleen lymphoid follicle relationship: capable_of GO:0043277 ! apoptotic cell clearance relationship: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer relationship: part_of UBERON:0001249 ! spleen lymphoid follicle [Term] id: CL:0000878 name: central nervous system macrophage namespace: cell def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000879 name: meningeal macrophage namespace: cell def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:11591794] is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: capable_of GO:0005044 ! scavenger receptor activity intersection_of: part_of UBERON:0002360 ! meninx relationship: capable_of GO:0005044 ! scavenger receptor activity relationship: part_of UBERON:0002360 ! meninx [Term] id: CL:0000880 name: choroid-plexus macrophage namespace: cell def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:9550136] is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: capable_of GO:0005044 ! scavenger receptor activity intersection_of: RO:0001025 UBERON:0001886 ! choroid plexus relationship: capable_of GO:0005044 ! scavenger receptor activity relationship: RO:0001025 UBERON:0001886 ! choroid plexus [Term] id: CL:0000881 name: perivascular macrophage namespace: cell def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: part_of UBERON:0001981 ! blood vessel relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: part_of UBERON:0001981 ! blood vessel [Term] id: CL:0000882 name: thymic medullary macrophage namespace: cell def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana, PMID:9048205] is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus [Term] id: CL:0000883 name: thymic cortical macrophage namespace: cell def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage namespace: cell def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19906191] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana, PMID:19906191] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: capable_of GO:0002387 ! immune response in gut-associated lymphoid tissue intersection_of: part_of UBERON:0001962 ! gut-associated lymphoid tissue relationship: capable_of GO:0002387 ! immune response in gut-associated lymphoid tissue relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue intersection_of: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue relationship: capable_of GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage namespace: cell def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [GO_REF:0000031, GOC:tfm, PMID:14668803, PMID:17934446, PMID:20228797] is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: adjacent_to UBERON:0002194 ! capsule of lymph node intersection_of: capable_of GO:0032816 ! positive regulation of natural killer cell activation intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: adjacent_to UBERON:0002194 ! capsule of lymph node relationship: capable_of GO:0032816 ! positive regulation of natural killer cell activation relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin [Term] id: CL:0000888 name: lymph node tingible body macrophage namespace: cell def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: capable_of GO:0002905 ! regulation of mature B cell apoptotic process intersection_of: capable_of GO:0043277 ! apoptotic cell clearance intersection_of: part_of UBERON:0002006 ! cortex of lymph node relationship: capable_of GO:0002905 ! regulation of mature B cell apoptotic process relationship: capable_of GO:0043277 ! apoptotic cell clearance relationship: part_of UBERON:0002006 ! cortex of lymph node [Term] id: CL:0000889 name: myeloid suppressor cell namespace: cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: bearer_of PATO:0001501 ! immature intersection_of: capable_of GO:0050777 ! negative regulation of immune response intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: bearer_of PATO:0001501 ! immature relationship: capable_of GO:0050777 ! negative regulation of immune response relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000890 name: alternatively activated macrophage namespace: cell def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:20510870] comment: Role or process: tissue remodeling. synonym: "M2 macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: capable_of GO:0048771 ! tissue remodeling intersection_of: has_part PR:000001844 ! arginase-1 relationship: capable_of GO:0048771 ! tissue remodeling relationship: has_part PR:000001844 ! arginase-1 [Term] id: CL:0000891 name: foam cell namespace: cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] xref: BTO:0003872 xref: FMA:83586 is_a: CL:0000003 ! native cell [Term] id: CL:0000892 name: smooth muscle cell derived foam cell namespace: cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000192 ! smooth muscle cell [Term] id: CL:0000893 name: thymocyte namespace: cell def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 xref: XAO:0003159 is_a: CL:0002420 {is_inferred="true"} ! immature T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 ! T cell selection intersection_of: part_of UBERON:0002370 ! thymus relationship: has_not_completed GO:0045058 ! T cell selection relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000894 name: DN1 thymic pro-T cell namespace: cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0002425 ! early T lineage precursor relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell namespace: cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699, PMID:22343568] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. synonym: "naive CD4+ T cell" BROAD [PMID:22343568] synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [GOC:tfm] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell namespace: cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000898 name: naive T cell namespace: cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_completed GO:0045058 ! T cell selection intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_completed GO:0045058 ! T cell selection relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000899 name: T-helper 17 cell namespace: cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875, PMID:20969597, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 CD4+ T cell" EXACT [PMID:22343568] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0032620 ! interleukin-17 production intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: capable_of GO:0032620 ! interleukin-17 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149, PMID:22343568] comment: This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. synonym: "naive CD8+ T cell" BROAD [PMID:22343568] synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000901 name: Tr1 cell namespace: cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam, PMID:16903904] comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0032613 ! interleukin-10 production intersection_of: capable_of GO:0050777 ! negative regulation of immune response relationship: capable_of GO:0032613 ! interleukin-10 production relationship: capable_of GO:0050777 ! negative regulation of immune response relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000902 name: induced T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 [Term] id: CL:0000903 name: natural T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4+ T cell" BROAD [PMID:22343568] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4+ T cell" BROAD [PMID:22343568] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000907 name: central memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8+ T cell" BROAD [PMID:22343568] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: capable_of GO:0001816 ! cytokine production relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000910 name: cytotoxic T cell namespace: cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: BTO:0000289 xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: capable_of GO:0001913 ! T cell mediated cytotoxicity relationship: capable_of GO:0001913 ! T cell mediated cytotoxicity [Term] id: CL:0000911 name: effector T cell namespace: cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_completed GO:0045058 ! T cell selection relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000912 name: helper T cell namespace: cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0001816 ! cytokine production [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8+ T cell" BROAD [PMID:22343568] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000914 name: immature NK T cell namespace: cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_part PR:000003469 ! early growth response protein 2 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000003469 ! early growth response protein 2 [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell namespace: cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000916 name: dendritic epidermal T cell namespace: cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: capable_of GO:0060054 ! positive regulation of epithelial cell proliferation involved in wound healing intersection_of: RO:0001025 UBERON:0001003 ! skin epidermis relationship: capable_of GO:0060054 ! positive regulation of epithelial cell proliferation involved in wound healing relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor relationship: RO:0001025 UBERON:0001003 ! skin epidermis [Term] id: CL:0000917 name: Tc1 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568, PMID:9914231] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells. synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 CD8+ T cell" EXACT [PMID:22343568] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] xref: BTO:0004793 xref: BTO:0004888 xref: FMA:84793 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21 intersection_of: has_part PR:000003463 ! eomesodermin intersection_of: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: capable_of GO:0032609 ! interferon-gamma production relationship: has_part PR:000001835 ! T-box transcription factor TBX21 relationship: has_part PR:000003463 ! eomesodermin relationship: has_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 [Term] id: CL:0000918 name: Tc2 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:9914231] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell. synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] xref: BTO:0004794 xref: FMA:84794 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: capable_of GO:0032633 ! interleukin-4 production relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] synonym: "CD8+CD25+ T(reg)" EXACT [] synonym: "CD8+CD25+ T-cell" EXACT [] synonym: "CD8+CD25+ T-lymphocyte " EXACT [] synonym: "CD8+CD25+ Treg" EXACT [] synonym: "CD8-positive, CD25-positive Treg" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell namespace: cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD28- T cell" EXACT [] synonym: "CD8+CD28- T lymphocyte" EXACT [] synonym: "CD8+CD28- T(reg)" EXACT [] synonym: "CD8+CD28- T-cell" EXACT [] synonym: "CD8+CD28- T-lymphocyte " EXACT [] synonym: "CD8+CD28- Treg" EXACT [] synonym: "CD8-positive, CD28-negative T(reg)" EXACT [] synonym: "CD8-positive, CD28-negative Treg" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28 relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28 [Term] id: CL:0000921 name: type I NK T cell namespace: cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: capable_of GO:0043208 ! glycosphingolipid binding relationship: capable_of GO:0043208 ! glycosphingolipid binding [Term] id: CL:0000922 name: type II NK T cell namespace: cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: capable_of GO:0002288 ! NK T cell activation involved in immune response relationship: capable_of GO:0002288 ! NK T cell activation involved in immune response [Term] id: CL:0000923 name: CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18997862] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: capable_of GO:0032609 ! interferon-gamma production relationship: capable_of GO:0032633 ! interleukin-4 production relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response relationship: capable_of GO:0032609 ! interferon-gamma production relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response intersection_of: capable_of GO:0032616 ! interleukin-13 production intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response relationship: capable_of GO:0032616 ! interleukin-13 production relationship: capable_of GO:0032633 ! interleukin-4 production relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: capable_of GO:0002369 ! T cell cytokine production intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: capable_of GO:0002369 ! T cell cytokine production relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response relationship: capable_of GO:0032609 ! interferon-gamma production relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response relationship: capable_of GO:0032633 ! interleukin-4 production relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000931 name: activated type II NK T cell namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: capable_of GO:0002369 ! T cell cytokine production intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: capable_of GO:0002369 ! T cell cytokine production relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, PMID:17964217] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: capable_of GO:0032609 ! interferon-gamma production relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 namespace: cell def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: capable_of GO:0032633 ! interleukin-4 production relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18440213] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: capable_of GO:0001913 ! T cell mediated cytotoxicity intersection_of: has_completed GO:0030217 ! T cell differentiation relationship: capable_of GO:0001913 ! T cell mediated cytotoxicity relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 [Term] id: CL:0000936 name: early lymphoid progenitor namespace: cell def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. synonym: "ELP" EXACT [] synonym: "GMLP" RELATED [PMID:18371378] synonym: "LMPP" EXACT [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: capable_of GO:0030098 ! lymphocyte differentiation intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: capable_of GO:0030098 ! lymphocyte differentiation relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A [Term] id: CL:0000937 name: pre-natural killer cell namespace: cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874] comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 {is_inferred="true"} ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor [Term] id: CL:0000938 name: CD16-negative, CD56-bright natural killer cell namespace: cell def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19796267, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. synonym: "CD16-CD56bright NK cell" EXACT [PMID:22343568] synonym: "CD16-negative, CD56-bright NK cell" EXACT [] synonym: "CD56-bright cytokine secreting natural killer cell" EXACT [] synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001319 ! SLAM family member 5 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA disjoint_from: CL:0000939 ! CD16-positive, CD56-dim natural killer cell relationship: capable_of GO:0032609 ! interferon-gamma production relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001319 ! SLAM family member 5 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0000939 name: CD16-positive, CD56-dim natural killer cell namespace: cell def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19796267, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types. synonym: "CD16+CD56+ NK cell" EXACT [PMID:22343568] synonym: "CD16-positive, CD56-dim NK cell" EXACT [] synonym: "CD16-positive, CD56-low natural killer cell" EXACT [] synonym: "CD16-positive, CD56-low NK cell" EXACT [] synonym: "CD16-positive, CD56-positive natural killer cell" EXACT [] synonym: "CD16-positive, CD56-positive NK cell" EXACT [] synonym: "cytotoxic CD56-dim natural killer cell" EXACT [] synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0042267 ! natural killer cell mediated cytotoxicity intersection_of: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0042267 ! natural killer cell mediated cytotoxicity relationship: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0000940 name: mucosal invariant T cell namespace: cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19416870] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: capable_of GO:0002227 ! innate immune response in mucosa intersection_of: capable_of GO:0032394 ! MHC class Ib receptor activity intersection_of: has_completed GO:0030217 ! T cell differentiation relationship: capable_of GO:0002227 ! innate immune response in mucosa relationship: capable_of GO:0032394 ! MHC class Ib receptor activity relationship: has_completed GO:0030217 ! T cell differentiation [Term] id: CL:0000941 name: thymic conventional dendritic cell namespace: cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629] comment: In the mouse this cell expresses CD8-alpha-alpha. is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell namespace: cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000943 name: Be1 Cell namespace: cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 1 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: capable_of GO:0032623 ! interleukin-2 production intersection_of: capable_of GO:0032640 ! tumor necrosis factor production intersection_of: capable_of GO:0045627 ! positive regulation of T-helper 1 cell differentiation relationship: capable_of GO:0032609 ! interferon-gamma production relationship: capable_of GO:0032623 ! interleukin-2 production relationship: capable_of GO:0032640 ! tumor necrosis factor production relationship: capable_of GO:0045627 ! positive regulation of T-helper 1 cell differentiation [Term] id: CL:0000944 name: Be2 cell namespace: cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 2 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: capable_of GO:0032613 ! interleukin-10 production intersection_of: capable_of GO:0032623 ! interleukin-2 production intersection_of: capable_of GO:0032633 ! interleukin-4 production intersection_of: capable_of GO:0032635 ! interleukin-6 production intersection_of: capable_of GO:0045630 ! positive regulation of T-helper 2 cell differentiation relationship: capable_of GO:0032613 ! interleukin-10 production relationship: capable_of GO:0032623 ! interleukin-2 production relationship: capable_of GO:0032633 ! interleukin-4 production relationship: capable_of GO:0032635 ! interleukin-6 production relationship: capable_of GO:0045630 ! positive regulation of T-helper 2 cell differentiation [Term] id: CL:0000945 name: lymphocyte of B lineage namespace: cell def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: develops_from CL:0000826 ! pro-B cell relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon [Term] id: CL:0000946 name: antibody secreting cell namespace: cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149] is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating relationship: produces GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000947 name: IgE plasma cell namespace: cell def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: produces GO:0071743 ! IgE immunoglobulin complex, circulating relationship: produces GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000948 name: IgE memory B cell namespace: cell def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex relationship: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex [Term] id: CL:0000949 name: IgD plasmablast namespace: cell def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: produces GO:0071739 ! IgD immunoglobulin complex, circulating relationship: produces GO:0071739 ! IgD immunoglobulin complex, circulating [Term] id: CL:0000950 name: IgE plasmablast namespace: cell def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: produces GO:0071743 ! IgE immunoglobulin complex, circulating relationship: produces GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000951 name: IgE short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: produces GO:0071743 ! IgE immunoglobulin complex, circulating relationship: produces GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell namespace: cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell namespace: cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000954 name: small pre-B-II cell namespace: cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:9785673] comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination [Term] id: CL:0000955 name: pre-B-II cell namespace: cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:9785673] comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination intersection_of: lacks_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule disjoint_from: CL:0000956 ! pre-B-I cell relationship: develops_from CL:0000826 ! pro-B cell relationship: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: lacks_part PR:000006611 ! DNA nucleotidylexotransferase relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule [Term] id: CL:0000956 name: pre-B-I cell namespace: cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:20839338, PMID:9785673] comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: develops_from CL:0000826 ! pro-B cell relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination [Term] id: CL:0000957 name: large pre-B-II cell namespace: cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, PMID:16551251, PMID:18432934, PMID:9785673] comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "large pre-B cell" BROAD [PMID:11244048] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: participates_in GO:0046651 ! lymphocyte proliferation relationship: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: participates_in GO:0046651 ! lymphocyte proliferation [Term] id: CL:0000958 name: T1 B cell namespace: cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000959 name: T2 B cell namespace: cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: develops_from CL:0000958 ! T1 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin [Term] id: CL:0000960 name: T3 B cell namespace: cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121] synonym: "An1 B cell" EXACT [PMID:17174121] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: participates_in GO:0002515 ! B cell anergy relationship: develops_from CL:0000959 ! T2 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: participates_in GO:0002515 ! B cell anergy [Term] id: CL:0000961 name: Bm1 B cell namespace: cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591] comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell is_a: CL:0002056 ! Fraction F mature B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000962 name: Bm2 B cell namespace: cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591] comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: develops_from CL:0000961 ! Bm1 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000963 name: Bm3-delta B cell namespace: cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752] synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000965 ! Bm3 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000964 name: Bm2' B cell namespace: cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:17992590, PMID:18432934, PMID:8006591] comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2' B-lymphocyte" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B lymphocyte " EXACT [] synonym: "Bm2-prime B-cell " EXACT [] synonym: "Bm2-prime B-lymphocyte " EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: capable_of GO:0002634 ! regulation of germinal center formation intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: capable_of GO:0002634 ! regulation of germinal center formation relationship: develops_from CL:0000962 ! Bm2 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000965 name: Bm3 B cell namespace: cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591] comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [PMID:8006591] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: capable_of GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: capable_of GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: develops_from CL:0000964 ! Bm2' B cell relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000966 name: Bm4 B cell namespace: cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591] comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [PMID:17992590] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase relationship: develops_from CL:0000963 ! Bm3-delta B cell relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase [Term] id: CL:0000967 name: Bm5 B cell namespace: cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:18432934, PMID:8006591] comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_completed GO:0002314 ! germinal center B cell differentiation intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: develops_from CL:0000966 ! Bm4 B cell relationship: has_completed GO:0002314 ! germinal center B cell differentiation relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000968 name: Be cell namespace: cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000969 name: regulatory B cell namespace: cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, MESH:D060151, PMID:11869683, PMID:18482568, PMID:20224569, PMID:20809522] comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. synonym: "B(reg)" EXACT [] synonym: "B10 cell" EXACT [] synonym: "Breg" EXACT [] synonym: "regulatory B lymphocyte" EXACT [] synonym: "regulatory B-cell" EXACT [] synonym: "regulatory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: capable_of GO:0032613 ! interleukin-10 production intersection_of: capable_of GO:0050777 ! negative regulation of immune response intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000002028 ! antigen-presenting glycoprotein CD1d relationship: capable_of GO:0032613 ! interleukin-10 production relationship: capable_of GO:0050777 ! negative regulation of immune response relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000002028 ! antigen-presenting glycoprotein CD1d [Term] id: CL:0000970 name: unswitched memory B cell namespace: cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "IgD+ memory B cell" BROAD [PMID:22343568] synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: develops_from CL:0000980 ! plasmablast relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 [Term] id: CL:0000971 name: IgM memory B cell namespace: cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676] comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000972 name: class switched memory B cell namespace: cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:9295047] comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_completed GO:0045190 ! isotype switching intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000970 ! unswitched memory B cell relationship: has_completed GO:0045190 ! isotype switching relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000973 name: IgA memory B cell namespace: cell def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:dsd, GOC:msz, ISBN:0781765196] comment: IgA memory B cell are also reportedly RORalpha-positive. synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex relationship: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex [Term] id: CL:0000974 name: long lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4 intersection_of: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1 intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0000975 ! short lived plasma cell relationship: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4 relationship: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1 relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0000975 name: short lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: bearer_of PATO:0001604 ! decreased life span relationship: bearer_of PATO:0001604 ! decreased life span relationship: develops_from CL:0000980 ! plasmablast [Term] id: CL:0000976 name: IgA short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: produces GO:0071746 ! IgA immunoglobulin complex, circulating relationship: produces GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000977 name: IgG short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: produces GO:0071736 ! IgG immunoglobulin complex, circulating relationship: produces GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000978 name: IgM short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: produces GO:0071754 ! IgM immunoglobulin complex, circulating relationship: produces GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000979 name: IgG memory B cell namespace: cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0000980 name: plasmablast namespace: cell def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2673126] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. xref: FMA:84371 is_a: CL:0000785 {is_inferred="true"} ! mature B cell is_a: CL:0000946 ! antibody secreting cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating relationship: develops_from CL:0000785 ! mature B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: produces GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000981 name: double negative memory B cell namespace: cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm] synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule [Term] id: CL:0000982 name: IgG plasmablast namespace: cell def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: produces GO:0071736 ! IgG immunoglobulin complex, circulating relationship: produces GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000983 name: IgM plasmablast namespace: cell def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: produces GO:0071754 ! IgM immunoglobulin complex, circulating relationship: produces GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000984 name: IgA plasmablast namespace: cell def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: produces GO:0071746 ! IgA immunoglobulin complex, circulating relationship: produces GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000985 name: IgG plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: produces GO:0071736 ! IgG immunoglobulin complex, circulating relationship: produces GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000986 name: IgM plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: produces GO:0071754 ! IgM immunoglobulin complex, circulating relationship: produces GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000987 name: IgA plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: produces GO:0071746 ! IgA immunoglobulin complex, circulating relationship: produces GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000988 name: hematopoietic cell namespace: cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell namespace: cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [GO_REF:0000031, GOC:amm, GOC:dsd, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000990 name: conventional dendritic cell namespace: cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell namespace: cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0032606 ! type I interferon production intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C intersection_of: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0032606 ! type I interferon production relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C relationship: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: capable_of GO:0019882 ! antigen processing and presentation intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule relationship: capable_of GO:0019882 ! antigen processing and presentation relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000997 name: immature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000998 name: CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [GO_REF:0000031, GOC:amm, http:www.immgen.org/index_content.html, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). synonym: "DC.8-4-11b-" EXACT [] synonym: "triple negative dendritic cell" EXACT [] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: capable_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: capable_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000999 name: CD4-positive CD11b-positive dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). synonym: "DC.4+" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0050728 ! negative regulation of inflammatory response intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0050728 ! negative regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0001000 name: CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). synonym: "DC.8+" EXACT [] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I intersection_of: capable_of GO:0050729 ! positive regulation of inflammatory response intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: capable_of GO:0050729 ! positive regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0001001 name: immature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001002 name: mature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: capable_of GO:0001816 ! cytokine production relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001003 name: mature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001004 name: immature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001005 name: mature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001006 name: dermal dendritic cell namespace: cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). xref: BTO:0004812 is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: part_of UBERON:0002067 ! dermis relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: part_of UBERON:0002067 ! dermis [Term] id: CL:0001007 name: interstitial dendritic cell namespace: cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001300 ! CD209 molecule intersection_of: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4 intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001300 ! CD209 molecule relationship: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4 relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 intersection_of: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0001009 name: immature dermal dendritic cell namespace: cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001010 name: mature dermal dendritic cell namespace: cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001009 ! immature dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001011 name: immature interstitial dendritic cell namespace: cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001013 name: mature interstitial dendritic cell namespace: cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001011 ! immature interstitial dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001014 name: CD1a-positive Langerhans cell namespace: cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. synonym: "CD1a-LC" EXACT [] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_plasma_membrane_part PR:000001447 ! cadherin-1 intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000001447 ! cadherin-1 relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0001015 name: CD8_alpha-low Langerhans cell namespace: cell def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75 intersection_of: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75 relationship: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell namespace: cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell namespace: cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001018 name: immature CD8_alpha-low Langerhans cell namespace: cell def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001020 name: mature CD8_alpha-low Langerhans cell namespace: cell def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0001022 name: CD115-positive monocyte namespace: cell def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 {is_inferred="true"} ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 {is_inferred="true"} ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell namespace: cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871] xref: CALOHA:TS-0448 xref: FMA:86475 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001786 ! prominin-1 intersection_of: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001786 ! prominin-1 relationship: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] comment: Markers are associated with mouse cells. synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: develops_from CL:0000936 ! early lymphoid progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001898 ! neprilysin relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell namespace: cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell namespace: cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA [Term] id: CL:0001029 name: common dendritic progenitor namespace: cell def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). synonym: "CDP" EXACT [PMID:21219184] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [PMID:21219184] is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell namespace: cell def: "Granule cell that is part of the cerebellum." [GOC:mah] xref: BTO:0004278 is_a: CL:0000120 {is_inferred="true"} ! granule cell is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0001032 name: cortical granule cell namespace: cell def: "Granule cell that is part of the cerebral cortex." [GOC:mah] is_a: CL:0000120 ! granule cell is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0001033 name: hippocampal granule cell namespace: cell def: "Granule cell that is part of the hippocampus." [GOC:mah] is_a: CL:0000120 ! granule cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:0001034 name: cell in vitro namespace: cell def: "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." [ReO:mhb] comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells. is_a: CL:0000000 ! cell is_a: GO:0005623 ! cell created_by: haendel creation_date: 2012-01-12T09:58:38Z [Term] id: CL:0001035 name: bone cell namespace: cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element created_by: adiehl creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001039 name: terminally differentiated osteoblast namespace: cl def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VSAO:curator] xref: VSAO:0000116 is_a: CL:0000062 ! osteoblast [Term] id: CL:0001040 name: non-terminally differentiated osteoblast namespace: cl def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 xref: VSAO:0000117 is_a: CL:0000062 ! osteoblast relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [GOC:dsd, PMID:19609979] comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ T-lymphocyte " EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: capable_of GO:0032613 ! interleukin-10 production intersection_of: capable_of GO:0032689 ! negative regulation of interferon-gamma production intersection_of: capable_of GO:0042130 ! negative regulation of T cell proliferation intersection_of: has_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: capable_of GO:0032613 ! interleukin-10 production relationship: capable_of GO:0032689 ! negative regulation of interferon-gamma production relationship: capable_of GO:0042130 ! negative regulation of T cell proliferation relationship: has_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0001042 name: T-helper 22 cell namespace: cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [GOC:dsd, PMID:19578368, PMID:19578369] comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0032626 ! interleukin-22 production relationship: capable_of GO:0032626 ! interleukin-22 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0001043 name: activated CD4-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD4+ T cell" BROAD [PMID:22343568] synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001044 name: effector CD4-positive, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568] synonym: "effector CD4+ T cell" BROAD [PMID:22343568] synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy." EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0001045 name: naive CCR4-positive regulatory T cell namespace: cell def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "naive CCR4+ Treg" EXACT [PMID:22343568] synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "naive CCR4-positive regulatory T-cell" EXACT [] synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002677 ! naive regulatory T cell intersection_of: CL:0002677 ! naive regulatory T cell intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 intersection_of: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 relationship: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO [Term] id: CL:0001046 name: memory CCR4-positive regulatory T cell namespace: cell def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "memory CCR4+ Treg" EXACT [PMID:22343568] synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "memory CCR4-positive regulatory T-cell" EXACT [] synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002678 ! memory regulatory T cell intersection_of: CL:0002678 ! memory regulatory T cell intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 [Term] id: CL:0001047 name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "CCR+ Treg" EXACT [PMID:22343568] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 relationship: has_plasma_membrane_part PR:000001200 ! C-C chemokine receptor type 4 [Term] id: CL:0001048 name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human namespace: cell def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CCR4+ Treg" EXACT [PMID:22343568] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell intersection_of: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001049 name: activated CD8-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD8+ T cell" BROAD [PMID:22343568] synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell intersection_of: CL:0000906 ! activated CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001050 name: effector CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. synonym: "effector CD8+ T cell" BROAD [PMID:22343568] synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Th1/Th17 CD4+ T cell" BROAD [PMID:22343568] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0001052 name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells. synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [PMID:22343568] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: lacks_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001207 ! C-X-C chemokine receptor type 3 [Term] id: CL:0001053 name: IgD-negative memory B cell namespace: cell def: "A memory B cell that lacks expression of surface IgD." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. synonym: "IgD- memory B cell" EXACT [PMID:22343568] is_a: CL:0000787 ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0001054 name: CD14-positive monocyte namespace: cell def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. synonym: "monocyte" NARROW [PMID:22343568] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0001055 name: CD14-positive, CD16-low monocyte namespace: cell def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [GOC:add, PMID:20628149] comment: Definition is valid for human intermediate monocytes. synonym: "intermediate monocyte, human" EXACT [] is_a: CL:0002393 ! intermediate monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte intersection_of: CL:0002393 ! intermediate monocyte intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule [Term] id: CL:0001056 name: dendritic cell, human namespace: cell def: "A dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells. synonym: "dendritic cell" BROAD [PMID:22343568] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001057 name: myeloid dendritic cell, human namespace: cell def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells. synonym: "myeloid dendritic cell" BROAD [PMID:22343568] is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0001056 ! dendritic cell, human intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA [Term] id: CL:0001058 name: plasmacytoid dendritic cell, human namespace: cell def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells. synonym: "plasmacytoid dendritic cell" BROAD [PMID:22343568] is_a: CL:0000784 ! plasmacytoid dendritic cell is_a: CL:0001056 ! dendritic cell, human intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000002015 ! MHC class II histocompatibility antigen alpha chain HLA-DRA relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-GEMM" RELATED [ISBN:0878932437] synonym: "CFU-S" RELATED [ISBN:0878932437] synonym: "CMP" BROAD [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] is_a: CL:0000049 ! common myeloid progenitor is_a: CL:0011115 ! precursor cell intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: capable_of GO:0002573 ! myeloid leukocyte differentiation intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: capable_of GO:0002573 ! myeloid leukocyte differentiation relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: bearer_of PATO:0001401 ! oligopotent intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: bearer_of PATO:0001401 ! oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001062 name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated namespace: cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [GOC:add, GOC:dos, PMID:15032595, PMID:16237082] comment: This cell type is seen human but not found in the mouse. synonym: "TEMRA" EXACT [PMID:16237082] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: develops_from CL:0000913 ! effector memory CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian namespace: cell def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G [Term] id: CL:0001070 name: beige adipocyte namespace: cell def: "A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." [] {comment="GOC:add", comment="GOC:cvs", comment="GOC:ymb", comment="PMID:22796012", comment="PMID:25851693"} synonym: "beige brown adipocyte" EXACT [] synonym: "beige fat cell" EXACT [] synonym: "beige/brite adipocyte" EXACT [] synonym: "brite adipocyte" EXACT [] synonym: "brite cell" EXACT [] synonym: "brite fat cell" EXACT [] is_a: CL:0000136 ! fat cell relationship: part_of UBERON:0001347 ! white adipose tissue [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004230 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] comment: Markers found on mouse cells. synonym: "c- Kit-positive erythroid progenitor cell" EXACT [] is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001345 ! endoglin relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] comment: Markers are found on mouse cells. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor relationship: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell markers associated with human cells. xref: FMA:83517 is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:14:30Z [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast namespace: cell def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell surface markers are associated with human cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:31:50Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-13T03:43:12Z [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [GOC:tfm, PMID:17582345] comment: Markers are found on mouse cells. is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-14T03:25:15Z [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [GOC:tfm, PMCID:PMC2626675] comment: Markers are associated with human cells. is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-14T03:25:17Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] synonym: "MDP" EXACT [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030224 ! monocyte differentiation intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation relationship: capable_of GO:0030224 ! monocyte differentiation relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell namespace: cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] comment: Markers are associated with mouse cells. synonym: "murine MDP" EXACT [] is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: has_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor created_by: tmeehan creation_date: 2010-01-26T02:43:40Z [Term] id: CL:0002012 name: Kit-low proerythroblast namespace: cell def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] comment: Markers are associated with mouse cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell relationship: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002013 name: GlyA-positive basophillic erythroblast namespace: cell def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers are associated with human cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-04-26T10:41:15Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast namespace: cell def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002012 ! Kit-low proerythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast namespace: cell def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast namespace: cell def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] comment: Cell surface markers are associated with human cells. is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:53:16Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts namespace: cell def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast namespace: cell def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers associated with human cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 created_by: tmeehan creation_date: 2010-04-26T11:04:21Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte namespace: cell def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294] comment: Marker associated with mouse cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002020 name: GlyA-positive reticulocytes namespace: cell def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers is associated with human cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T11:48:25Z [Term] id: CL:0002021 name: GlyA-positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094] comment: Marker is associated with human cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T11:51:22Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084] comment: Marker is associated with mouse cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-04-26T11:51:27Z [Term] id: CL:0002023 name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell namespace: cell def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are associated with human cell type. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-26T02:39:09Z [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553] comment: Markers are associated with mouse cells. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T02:39:15Z [Term] id: CL:0002025 name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb intersection_of: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain created_by: tmeehan creation_date: 2010-04-26T03:52:47Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell namespace: cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm] comment: Markers are commonly associated with mouse cells. is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002028 name: basophil mast progenitor cell namespace: cell def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421] comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. synonym: "BMCP" EXACT [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0030221 ! basophil differentiation intersection_of: capable_of GO:0060374 ! mast cell differentiation intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: capable_of GO:0030221 ! basophil differentiation relationship: capable_of GO:0060374 ! mast cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 created_by: tmeehan creation_date: 2010-04-27T12:46:33Z [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor namespace: cell def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [GOC:tfm, PMCID:PMC1312421] is_a: CL:0000831 {is_inferred="true"} ! mast cell progenitor intersection_of: CL:0000831 ! mast cell progenitor intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000009143 ! integrin beta-7 intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000009143 ! integrin beta-7 relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:19Z [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell namespace: cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [GOC:tfm, PMCID:PMC1312421] comment: Markers are associated with mouse cells. is_a: CL:0000613 {is_inferred="true"} ! basophil progenitor cell intersection_of: CL:0000613 ! basophil progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:32Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001400 ! unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: bearer_of PATO:0001400 ! unipotent relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001401 ! oligopotent relationship: bearer_of PATO:0001401 ! oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. synonym: "ST stem cell" EXACT [] synonym: "ST-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: develops_from CL:0002034 ! long term hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 created_by: tmeehan creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] comment: Markers are associated with mouse cells. synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 created_by: tmeehan creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 created_by: tmeehan creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "KSL cell" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: develops_from CL:0002033 ! short term hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell namespace: cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:tfm, PMID:16048545] synonym: "memory alpha beta IEL" EXACT [PMID:16048545] is_a: CL:0000793 {is_inferred="true"} ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 created_by: tmeehan creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell namespace: cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402, PMID:20107805, PMID:22043829] synonym: "follicular B helper T cell" RELATED [PMID:22043829] synonym: "follicular helper T cell" RELATED [PMID:22649468] synonym: "follicular helper T-cell" RELATED [PMID:22508770] synonym: "follicular T cell" RELATED [PMID:20107805, PMID:21914188] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [PMID:22552227] synonym: "T(FH)" EXACT [PMID:20207847] synonym: "Tfh" EXACT [PMID:20107805, PMID:20383172] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0045830 ! positive regulation of isotype switching intersection_of: capable_of GO:0051024 ! positive regulation of immunoglobulin secretion intersection_of: has_part PR:000003450 ! B-cell lymphoma 6 protein intersection_of: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5 intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: capable_of GO:0045830 ! positive regulation of isotype switching relationship: capable_of GO:0051024 ! positive regulation of immunoglobulin secretion relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000003450 ! B-cell lymphoma 6 protein relationship: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5 relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 created_by: tmeehan creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I namespace: cell def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:17589542] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II namespace: cell def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002039 ! immature NK T cell stage I relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III namespace: cell def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2 intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002040 ! immature NK T cell stage II relationship: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV namespace: cell def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2 intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002041 ! immature NK T cell stage III relationship: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein created_by: tmeehan creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell namespace: cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [GOC:ak, GOC:tfm] comment: Markers are associated with mouse cells. is_a: CL:0002028 {is_inferred="true"} ! basophil mast progenitor cell intersection_of: CL:0002028 ! basophil mast progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:38Z [Term] id: CL:0002045 name: Fraction A pre-pro B cell namespace: cell def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343] comment: Markers associated with mouse cells. synonym: "fraction A" EXACT [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 created_by: tmeehan creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: early pro-B cell namespace: cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination created_by: tmeehan creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002047 name: Fraction B precursor B cell namespace: cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. synonym: "Fr. B" EXACT [] synonym: "Fraction B" EXACT [] is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell intersection_of: CL:0002400 ! Fraction B/C precursor B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase created_by: tmeehan creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell namespace: cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0002046 ! early pro-B cell relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 created_by: tmeehan creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: Fraction C precursor B cell namespace: cell def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343] synonym: "Fraction C" RELATED [] is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell intersection_of: CL:0002400 ! Fraction B/C precursor B cell intersection_of: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination intersection_of: has_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: develops_from CL:0002047 ! Fraction B precursor B cell relationship: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: has_part PR:000001858 ! immunoglobulin iota chain relationship: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2 created_by: tmeehan creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: Fraction C' precursor B cell namespace: cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343] synonym: "Fr. C'" EXACT [] synonym: "Fraction C-prime" EXACT [] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: develops_from CL:0002049 ! Fraction C precursor B cell relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase created_by: tmeehan creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell namespace: cell def: "A pre-BCR positive T cell that is CD38-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cells. synonym: "large pre-B cell type I" RELATED [] is_a: CL:0000952 {is_inferred="true"} ! preBCR-positive large pre-B-II cell intersection_of: CL:0000952 ! preBCR-positive large pre-B-II cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: develops_from CL:0002048 ! late pro-B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 created_by: tmeehan creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: Fraction D precursor B cell namespace: cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343, PMID:18432934] comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. synonym: "Fr. D" EXACT [] synonym: "Fraction D pre-B cell" EXACT [GOC:tfm] is_a: CL:0002400 ! Fraction B/C precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: develops_from CL:0002050 ! Fraction C' precursor B cell relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex created_by: tmeehan creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell namespace: cell def: "A small pre-B cell that is CD22-positive and CD38-low." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell. RAG expression maybe diminishing. synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 {is_inferred="true"} ! small pre-B-II cell intersection_of: CL:0000954 ! small pre-B-II cell intersection_of: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell relationship: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 created_by: tmeehan creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: Fraction E immature B cell namespace: cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, PMID:17582343, PMID:18432934] comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative. is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0002052 ! Fraction D precursor B cell relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha created_by: tmeehan creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell namespace: cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell type. is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22 intersection_of: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell relationship: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22 relationship: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2 relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 created_by: tmeehan creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: Fraction F mature B cell namespace: cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, PMID:17582343] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: develops_from CL:0002054 ! Fraction E immature B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor created_by: tmeehan creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative classical monocyte namespace: cell def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." [GOC:add, GOC:tfm, PMID:15615263, PMID:1706877, PMID:19689341, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. synonym: "CD16- monocyte" EXACT [PMID:22343568] synonym: "CD16-negative monocyte" EXACT [] is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low non-classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [GOC:tfm, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte relationship: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R created_by: tmeehan creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8alpha-positive thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage namespace: cell def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_part CHEBI:25179 ! melanin intersection_of: part_of UBERON:0002097 ! skin of body relationship: has_part CHEBI:25179 ! melanin relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell namespace: cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [GOC:tfm, PMID:18931678, PMID:19604299, PMID:20154671] synonym: "T helper cells type 9" EXACT [] synonym: "T(H)-9 cell" EXACT [] synonym: "Th9" EXACT [PMID:18931678] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: capable_of GO:0002215 ! defense response to nematode intersection_of: capable_of GO:0032638 ! interleukin-9 production intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B relationship: capable_of GO:0002215 ! defense response to nematode relationship: capable_of GO:0032638 ! interleukin-9 production relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B created_by: tmeehan creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002062 name: type I pneumocyte namespace: cell def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144] synonym: "AT1" EXACT [] synonym: "ATI" EXACT [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "type 1 pneumocyte" EXACT [] synonym: "type I alveolar cells" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] xref: BTO:0000780 xref: FMA:62500 is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange relationship: capable_of GO:0007585 ! respiratory gaseous exchange created_by: tmeehan creation_date: 2010-06-23T04:37:54Z [Term] id: CL:0002063 name: type II pneumocyte namespace: cell def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:8540632] synonym: "AT2" EXACT [] synonym: "ATII" EXACT [] synonym: "cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "great alveolar cell" EXACT [] synonym: "lung type 2 cell" EXACT [] synonym: "lung type II cell" RELATED [] synonym: "TII" EXACT [] synonym: "type 2 alveolar epithelial cell" EXACT [] synonym: "type 2 alveolocyte" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar cell" EXACT [] synonym: "type II alveolar epithelial cell" EXACT [] synonym: "type II alveolocyte" EXACT [] xref: BTO:0000538 xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: capable_of GO:0032940 ! secretion by cell intersection_of: capable_of GO:0043129 ! surfactant homeostasis relationship: capable_of GO:0032940 ! secretion by cell relationship: capable_of GO:0043129 ! surfactant homeostasis created_by: tmeehan creation_date: 2010-06-24T12:04:13Z [Term] id: CL:0002064 name: pancreatic acinar cell namespace: cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 is_a: CL:0000083 {is_inferred="true"} ! epithelial cell of pancreas is_a: CL:0000622 {is_inferred="true"} ! acinar cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: has_part GO:0042589 ! zymogen granule membrane relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell namespace: cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] synonym: "P cell" BROAD [] synonym: "respiratory enterochromaffin cell " EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell created_by: tmeehan creation_date: 2010-06-28T08:24:30Z [Term] id: CL:0002067 name: type A enterocrine cell namespace: cell def: "An enterocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0070091 ! glucagon secretion relationship: capable_of GO:0070091 ! glucagon secretion created_by: tmeehan creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte namespace: cell def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002069 name: type II vestibular sensory cell namespace: cell def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651] synonym: "type 2 vestibular hair cell" EXACT [] synonym: "type 2 vestibular sensory cell" EXACT [] synonym: "type II hair cell" EXACT [] xref: FMA:67909 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:13Z [Term] id: CL:0002070 name: type I vestibular sensory cell namespace: cell def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651] synonym: "type 1 vestibular hair cell" EXACT [] synonym: "type 1 vestibular sensory cell" EXACT [] synonym: "type I hair cell" EXACT [] xref: FMA:62352 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:19Z [Term] id: CL:0002071 name: enterocyte of epithelium of large intestine namespace: cell def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [GOC:tfm, ISBN:0517223651] synonym: "columnar cell" BROAD [] synonym: "columnar cell of the colon" EXACT [] synonym: "vacuolar absorptive cell" EXACT [] xref: BTO:0002484 xref: FMA:63638 xref: FMA:66771 is_a: CL:0000584 ! enterocyte is_a: CL:0002253 {is_inferred="true"} ! epithelial cell of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001278 ! epithelium of large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine created_by: tmeehan creation_date: 2010-06-29T11:07:25Z [Term] id: CL:0002072 name: nodal myocyte namespace: cell def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte namespace: cell def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell namespace: cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002075 name: brush cell of trachebronchial tree namespace: cell def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "pulmonary brush cell" RELATED [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002204 ! brush cell intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-06-29T03:22:46Z [Term] id: CL:0002076 name: endo-epithelial cell namespace: cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] xref: FMA:69075 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000223 ! endodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell namespace: cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000221 ! ectodermal cell relationship: develops_from CL:0000221 ! ectodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell namespace: cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000222 ! mesodermal cell created_by: tmeehan creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell namespace: cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] xref: FMA:63099 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0000083 {is_inferred="true"} ! epithelial cell of pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001064 ! ventral pancreatic duct created_by: tmeehan creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell namespace: cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:0000083 {is_inferred="true"} ! epithelial cell of pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002081 name: type II cell of carotid body namespace: cell def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227] synonym: "sheath cell of carotid body" EXACT [] xref: FMA:84187 is_a: CL:0000703 ! sustentacular cell is_a: CL:0002256 ! supporting cell of carotid body created_by: tmeehan creation_date: 2010-06-30T04:23:42Z [Term] id: CL:0002082 name: type II cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm] synonym: "adremergic chromaffin cell" EXACT [] synonym: "adrenal secreting cell of the adrenal medulla" EXACT [] synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrine secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: capable_of GO:0048242 ! epinephrine secretion intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: capable_of GO:0048242 ! epinephrine secretion relationship: part_of UBERON:0001236 ! adrenal medulla created_by: tmeehan creation_date: 2010-07-14T09:41:42Z [Term] id: CL:0002083 name: type I cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X] synonym: "noradrenergic chromaffin cell" EXACT [] xref: FMA:69321 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000459 ! noradrenergic cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: capable_of GO:0048243 ! norepinephrine secretion intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: capable_of GO:0048243 ! norepinephrine secretion relationship: part_of UBERON:0001236 ! adrenal medulla created_by: tmeehan creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell namespace: cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell] synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] synonym: "Bottcher's cell" EXACT [] is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-07-14T03:22:02Z [Term] id: CL:0002085 name: tanycyte namespace: cell alt_id: CL:0000643 def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte] synonym: "stretch cell" EXACT [] xref: BTO:0001953 xref: FMA:54560 is_a: CL:0000683 ! ependymoglial cell created_by: tmeehan creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte namespace: cell def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte namespace: cell def: "A leukocyte that lacks granules." [GOC:tfm] synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: lacks_part GO:0030141 ! secretory granule relationship: lacks_part GO:0030141 ! secretory granule created_by: tmeehan creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal namespace: cell def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction relationship: capable_of GO:0043134 ! regulation of hindgut contraction created_by: tmeehan creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002089 name: nuocyte namespace: cell def: "A leukocyte cell capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:tfm, PMID:20200518] is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response intersection_of: capable_of GO:0032616 ! interleukin-13 production intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B intersection_of: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2 intersection_of: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5 intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response relationship: capable_of GO:0032616 ! interleukin-13 production relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B relationship: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2 relationship: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1 relationship: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5 relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha created_by: tmeehan creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002090 name: polar body namespace: cell def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X] xref: EHDAA2:0004716 xref: FMA:85543 xref: WBbt:0008429 xref: XAO:0000262 is_a: CL:0000021 ! female germ cell created_by: tmeehan creation_date: 2010-08-23T09:49:53Z [Term] id: CL:0002091 name: primary polar body namespace: cell def: "A small cell formed by the first meiotic division of oocytes." [GOC:tfm, ISBN:068340007X] synonym: "first polar body" EXACT [EHDAA2:0000541] synonym: "polocytus primarius" EXACT [FMA:18650] xref: EHDAA2:0000541 xref: EMAPA:16032 xref: FMA:18650 xref: VHOG:0000464 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:49:58Z [Term] id: CL:0002092 name: bone marrow cell namespace: cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. xref: BTO:0004850 xref: FMA:83621 is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002093 name: secondary polar body namespace: cell def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [GOC:tfm, ISBN:068340007X] synonym: "polocytus secundarius" EXACT [FMA:18651] synonym: "second polar body" EXACT [EHDAA2:0001820] xref: EHDAA2:0001820 xref: EMAPA:16034 xref: EMAPA:16045 xref: FMA:18651 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:50:01Z [Term] id: CL:0002094 name: interstitial cell of ovary namespace: cell def: "A cell that makes up the loose connective tissue of the ovary." [GOC:tfm] xref: FMA:18709 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:11:34Z [Term] id: CL:0002095 name: hilus cell of ovary namespace: cell def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002096 name: internodal tract myocyte namespace: cell def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300] xref: FMA:223275 is_a: CL:0002086 ! specialized cardiac myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract created_by: tmeehan creation_date: 2010-08-23T11:24:11Z [Term] id: CL:0002097 name: cortical cell of adrenal gland namespace: cell def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm] synonym: "adrenal cortex cell" EXACT [] synonym: "adrenocortical cell" EXACT [] xref: FMA:69545 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex created_by: tmeehan creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002098 name: regular cardiac myocyte namespace: cell def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." [GOC:tfm] synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] xref: FMA:67967 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-08-23T11:33:10Z [Term] id: CL:0002099 name: type I cell of adrenal cortex namespace: cell alt_id: CL:1000423 def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651] synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT [] xref: FMA:69273 is_a: CL:0000456 ! mineralocorticoid secreting cell is_a: CL:0002097 {is_inferred="true"} ! cortical cell of adrenal gland intersection_of: CL:0002097 ! cortical cell of adrenal gland intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:42:02Z [Term] id: CL:0002100 name: regular interventricular cardiac myocyte namespace: cell def: "A regular cardiac myocyte of the interventricular region of the heart." [GOC:tfm] xref: FMA:228792 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:40:52Z [Term] id: CL:0002101 name: CD38-positive naive B cell namespace: cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002102 name: CD38-negative naive B cell namespace: cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002103 name: IgG-positive double negative memory B cell namespace: cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002104 name: IgG-negative double negative memory B cell namespace: cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002105 name: CD38-positive IgG memory B cell namespace: cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell namespace: cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell namespace: cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0001053 ! IgD-negative memory B cell is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0002108 name: CD38-negative IgG memory B cell namespace: cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell namespace: cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell namespace: cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002109 ! B220-positive CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell namespace: cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell namespace: cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell namespace: cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell namespace: cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell namespace: cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell namespace: cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002117 name: IgG-negative class switched memory B cell namespace: cell def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell namespace: cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: capable_of GO:0032609 ! interferon-gamma production relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta-17 cells" EXACT [PMID:21976777] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: capable_of GO:0032620 ! interleukin-17 production intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: capable_of GO:0032620 ! interleukin-17 production relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell namespace: cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [GOC:tfm, PMID:19270712] is_a: CL:0000799 {is_inferred="true"} ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000799 ! immature gamma-delta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule intersection_of: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 intersection_of: part_of UBERON:0002370 ! thymus relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule relationship: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell namespace: cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [GOC:tfm, PMID:20581831] is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: capable_of GO:0045087 ! innate immune response relationship: capable_of GO:0045087 ! innate immune response created_by: tmeehan creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [GOC:add, GOC:dsd, GOC:tfm, PMID:19201830, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). synonym: "Tc17 CD8+ T cell" EXACT [PMID:22343568] synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: capable_of GO:0032620 ! interleukin-17 production intersection_of: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5 intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: capable_of GO:0032620 ! interleukin-17 production relationship: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5 relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA [Term] id: CL:0002129 name: regular atrial cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac atrium." [GOC:tfm] synonym: "atrial cardiac muscle cell" EXACT [GOC:pr] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] xref: FMA:83108 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:03Z [Term] id: CL:0002130 name: regular interatrial cardiac myocyte namespace: cell def: "A cardiac myocyte of the interatrial region of the heart." [GOC:tfm] xref: FMA:228790 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:09Z [Term] id: CL:0002131 name: regular ventricular cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac ventricle." [GOC:tfm] synonym: "regular cardiac muscle cell of ventricle" EXACT [] synonym: "regular ventricular cardiac muscle fiber" EXACT [] synonym: "ventricular cardiac muscle cell" BROAD [GOC:pr] synonym: "ventricular myocyte" EXACT [] xref: FMA:83109 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:13Z [Term] id: CL:0002132 name: stromal cell of ovary namespace: cell def: "A stomal cell of the ovary" [GOC:tfm] synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad created_by: tmeehan creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002133 name: stromal cell of ovarian cortex namespace: cell def: "A stromal cell of the ovarian cortex." [GOC:tfm] xref: FMA:256169 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T12:12:15Z [Term] id: CL:0002134 name: stromal cell of ovarian medulla namespace: cell def: "A stromal cell of the ovarian medulla." [GOC:tfm] xref: FMA:256171 is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0013192 ! ovarian medulla relationship: part_of UBERON:0013192 ! ovarian medulla created_by: tmeehan creation_date: 2010-08-23T12:12:17Z [Term] id: CL:0002135 name: nonkeratinized cell of epidermis namespace: cell def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [GO:tfm, PMID:1987287] xref: FMA:62880 is_a: CL:0000362 ! epidermal cell relationship: part_of UBERON:0001003 ! skin epidermis created_by: tmeehan creation_date: 2010-08-24T08:43:27Z [Term] id: CL:0002136 name: type II cell of adrenal cortex namespace: cell def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651] synonym: "type II cortical cell of adrenal gland" EXACT [] xref: FMA:69547 is_a: CL:0000460 ! glucocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:42Z [Term] id: CL:0002137 name: type III cell of adrenal cortex namespace: cell def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651] xref: FMA:69564 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:44Z [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel namespace: cell alt_id: CL:1000421 def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148] synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] xref: BTO:0004167 xref: FMA:68458 is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: develops_from CL:0005022 ! vascular lymphangioblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: develops_from CL:0005022 ! vascular lymphangioblast relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002139 name: endothelial cell of vascular tree namespace: cell def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002140 name: acinar cell of sebaceous gland namespace: cell alt_id: CL:0002587 def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." [GOC:tfm] synonym: "sebocyte" EXACT [] xref: BTO:0004613 xref: FMA:70953 is_a: CL:0000317 {is_inferred="true"} ! sebum secreting cell is_a: CL:0000622 ! acinar cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000317 ! sebum secreting cell intersection_of: part_of UBERON:0003487 ! skin sebaceous gland relationship: part_of UBERON:0003487 ! skin sebaceous gland created_by: tmeehan creation_date: 2010-08-24T09:27:52Z [Term] id: CL:0002141 name: active chief cell of parathyroid gland namespace: cell def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [FMA:0517223651, GOC:tfm] xref: FMA:69082 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T09:30:15Z [Term] id: CL:0002142 name: dark cell of eccrine sweat gland namespace: cell def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [ISBN:0517223651] xref: FMA:70659 is_a: CL:0000152 ! exocrine cell is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell is_a: CL:1000448 ! epithelial cell of sweat gland relationship: part_of UBERON:0000423 ! eccrine sweat gland created_by: tmeehan creation_date: 2010-08-24T02:15:16Z [Term] id: CL:0002143 name: dark chief cell of parathyroid cell namespace: cell def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69080 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T02:18:36Z [Term] id: CL:0002144 name: capillary endothelial cell namespace: cell def: "An endothelial cell found in capillaries." [GOC:tfm] xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary created_by: tmeehan creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree namespace: cell def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell relationship: develops_from CL:0002209 ! intermediate epitheliocyte created_by: tmeehan creation_date: 2010-08-24T03:38:29Z [Term] id: CL:0002146 name: clear cell of eccrine sweat gland namespace: cell def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [GOC:tfm, ISBN:0517223651] xref: FMA:70658 is_a: CL:0000152 ! exocrine cell is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell is_a: CL:1000448 ! epithelial cell of sweat gland relationship: part_of UBERON:0000423 ! eccrine sweat gland created_by: tmeehan creation_date: 2010-08-24T10:33:02Z [Term] id: CL:0002147 name: clear chief cell of parathyroid cell namespace: cell def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [GOC:tfm, ISBN:0618947256] xref: FMA:69081 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T10:39:42Z [Term] id: CL:0002148 name: dental pulp cell namespace: cell def: "A cell found within the dental pulp." [GOC:tfm, PMID:11087820] xref: BTO:0000339 xref: CALOHA:TS-0195 xref: FMA:87170 is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: part_of UBERON:0001754 ! dental pulp relationship: part_of UBERON:0001754 ! dental pulp created_by: tmeehan creation_date: 2010-08-24T02:52:09Z [Term] id: CL:0002149 name: epithelial cell of uterus namespace: cell alt_id: CL:1000294 def: "An epithelial cell of the uterus." [GOC:tfm] xref: FMA:256161 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2010-08-24T10:45:54Z [Term] id: CL:0002150 name: epithelioid macrophage namespace: cell def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [MESH:A11.329.372.300, PMID:12673090] synonym: "epithelioid cell" BROAD [] synonym: "epithelioid histocyte" EXACT [MESH:A11.329.372.300, PMID:12673090] synonym: "epitheloid macrophage" EXACT [] xref: FMA:83514 is_a: CL:0000235 ! macrophage relationship: develops_from CL:0000861 ! elicited macrophage created_by: tmeehan creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002151 name: late promyelocyte namespace: cell def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [ISBN:0412046911] xref: FMA:83534 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:50Z [Term] id: CL:0002152 name: columnar cell of endocervix namespace: cell def: "A columnar cell of the cervix uteri." [GOC:tfm, ISBN:0721662544] xref: FMA:86486 is_a: CL:0002149 ! epithelial cell of uterus relationship: part_of UBERON:0000458 ! endocervix created_by: tmeehan creation_date: 2010-08-24T10:47:47Z [Term] id: CL:0002153 name: corneocyte namespace: cell def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X] xref: BTO:0001943 xref: FMA:68650 is_a: CL:0000225 ! anucleate cell is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000312 ! keratinocyte relationship: part_of UBERON:0002027 ! stratum corneum of epidermis created_by: tmeehan creation_date: 2010-08-24T10:53:03Z [Term] id: CL:0002154 name: early promyelocyte namespace: cell def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [FMA:0412046911, GOC:tfm] xref: FMA:83533 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:53Z [Term] id: CL:0002155 name: echinocyte namespace: cell def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [GOC:tfm] synonym: "burr cell" EXACT [] xref: FMA:81099 is_a: CL:0000595 ! enucleate erythrocyte created_by: tmeehan creation_date: 2010-08-24T03:15:21Z [Term] id: CL:0002157 name: endosteal cell namespace: cell def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [FMA:0618947256, GOC:tfm] xref: FMA:86495 is_a: CL:0002078 ! meso-epithelial cell relationship: part_of UBERON:0009859 ! endosteum created_by: tmeehan creation_date: 2010-08-24T03:33:58Z [Term] id: CL:0002158 name: external epithelial cell of tympanic membrane namespace: cell def: "Epithelial cell found on the external side of the tympanic membrane" [GOC:tfm, PMID:5686391] xref: FMA:70558 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-25T10:25:31Z [Term] id: CL:0002159 name: general ecto-epithelial cell namespace: cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002160 name: basal external epithelial cell of tympanic membrane namespace: cell def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:44Z [Term] id: CL:0002161 name: superficial external epithelial cell of tympanic membrane namespace: cell def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:48Z [Term] id: CL:0002162 name: internal epithelial cell of tympanic membrane namespace: cell def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [FMA:5686391, GOC:tfm] xref: FMA:70626 is_a: CL:0002076 ! endo-epithelial cell relationship: part_of UBERON:0002364 ! tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:49:46Z [Term] id: CL:0002163 name: internal pillar cell of cochlea namespace: cell def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75722 xref: FMA:75726 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:21Z [Term] id: CL:0002164 name: external pillar cell of cochlea namespace: cell def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75727 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:23Z [Term] id: CL:0002165 name: phalangeal cell namespace: cell def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256] xref: FMA:79800 is_a: CL:0002490 ! organ of Corti supporting cell created_by: tmeehan creation_date: 2010-08-25T01:29:07Z [Term] id: CL:0002166 name: epithelial cell of Malassez namespace: cell def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521] synonym: "epithelial cell rests of Malassez " EXACT [] synonym: "epithelial debris of Malassez" EXACT [] xref: FMA:62987 is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell relationship: part_of UBERON:0011595 ! jaw region created_by: tmeehan creation_date: 2010-08-26T08:51:27Z [Term] id: CL:0002167 name: olfactory epithelial cell namespace: cell def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026] xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell created_by: tmeehan creation_date: 2010-08-26T01:47:13Z [Term] id: CL:0002168 name: border cell of cochlea namespace: cell def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [FMA:0412046911, GOC:tfm] xref: FMA:79798 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T01:47:12Z [Term] id: CL:0002169 name: basal cell of olfactory epithelium namespace: cell alt_id: CL:1000395 def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026] synonym: "horizontal basal call" BROAD [] xref: FMA:62303 is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell intersection_of: CL:0002167 ! olfactory epithelial cell intersection_of: part_of UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0001997 ! olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:58:54Z [Term] id: CL:0002170 name: keratinized cell of the oral mucosa namespace: cell def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID:12014572] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002336 ! buccal mucosa cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0003729 ! mouth mucosa created_by: tmeehan creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium namespace: cell def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753] synonym: "blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea namespace: cell def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [GOC:tfm, MP:0004482, PMID:2111803] synonym: "interdental cell" EXACT [] xref: FMA:79797 is_a: CL:0002315 ! supporting cell of cochlea relationship: part_of UBERON:0002276 ! lamina of spiral limbus created_by: tmeehan creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell namespace: cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911] synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] synonym: "polar cushion cells" EXACT [] xref: FMA:84143 xref: KUPO:0001033 is_a: CL:0000650 ! mesangial cell is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell is_a: CL:1001318 ! renal interstitial pericyte intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002321 ! extraglomerular mesangium relationship: part_of UBERON:0002321 ! extraglomerular mesangium created_by: tmeehan creation_date: 2010-08-25T02:20:55Z [Term] id: CL:0002174 name: follicular cell of ovary namespace: cell def: "A cell within the follicle of an ovary." [GOC:tfm] xref: EMAPA:31247 xref: FMA:70589 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-25T03:01:27Z [Term] id: CL:0002175 name: primary follicular cell of ovary namespace: cell def: "A cell within the primary follicle of the ovary." [GOC:tfm] xref: FMA:70590 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:42Z [Term] id: CL:0002176 name: secondary follicular cell of ovary namespace: cell def: "A cell of a secondary follicile within the ovary." [GOC:tfm] xref: FMA:70591 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:48Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis namespace: cell def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000642 ! folliculostellate cell intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002178 name: epithelial cell of stomach namespace: cell alt_id: CL:1000399 def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] xref: FMA:62948 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002179 name: foveolar cell of stomach namespace: cell def: "An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop ." [GOC:tfm, http://www.merriam-webster.com/medical/foveolar] xref: FMA:86552 is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:23:22Z [Term] id: CL:0002180 name: mucous cell of stomach namespace: cell alt_id: CL:1000404 def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: part_of UBERON:0001199 ! mucosa of stomach relationship: part_of UBERON:0001199 ! mucosa of stomach created_by: tmeehan creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002181 name: mucus neck cell of gastric gland namespace: cell alt_id: CL:1000401 def: "A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach." [GOC:tfm, ISBN:0517223651] xref: FMA:62954 is_a: CL:0000152 ! exocrine cell is_a: CL:0000651 {is_inferred="true"} ! mucous neck cell is_a: CL:0002180 {is_inferred="true"} ! mucous cell of stomach intersection_of: CL:0000651 ! mucous neck cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:41:30Z [Term] id: CL:0002182 name: surface mucosal cell of stomach namespace: cell def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651] xref: FMA:62949 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002180 ! mucous cell of stomach relationship: capable_of GO:0070254 ! mucus secretion created_by: tmeehan creation_date: 2010-08-25T03:45:10Z [Term] id: CL:0002183 name: stem cell of gastric gland namespace: cell alt_id: CL:1000400 def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] xref: FMA:62953 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium namespace: cell def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623] synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:22Z [Term] id: CL:0002187 name: basal cell of epidermis namespace: cell alt_id: CL:1000439 def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [GOC:tfm, ISBN:0517223651] xref: FMA:70571 is_a: CL:0000312 ! keratinocyte is_a: CL:0000646 {is_inferred="true"} ! basal cell is_a: CL:1000428 ! stem cell of epidermis intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis created_by: tmeehan creation_date: 2010-08-26T03:12:49Z [Term] id: CL:0002188 name: glomerular endothelial cell namespace: cell def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009] xref: BTO:0004632 xref: FMA:70970 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell is_a: CL:0000666 ! fenestrated cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus created_by: tmeehan creation_date: 2010-08-26T10:59:44Z [Term] id: CL:0002189 name: granular cell of epidermis namespace: cell def: "A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules." [ISBN:1416031855] xref: FMA:70543 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:19:00Z [Term] id: CL:0002190 name: squamous cell of epidermis namespace: cell def: "A flat keratinocyte immediately below the cornified layer." [GOC:tfm, ISBN:0517223651] xref: FMA:86925 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:37:02Z [Term] id: CL:0002191 name: granulocytopoietic cell namespace: cell def: "A cell involved in the formation of a granulocyte." [GOC:tfm] xref: FMA:83519 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0030851 ! granulocyte differentiation relationship: capable_of GO:0030851 ! granulocyte differentiation created_by: tmeehan creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002192 name: metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [GOC:tfm, http://en.wikipedia.org/wiki/Metamyelocyte, ISBN:0721601464] xref: FMA:83541 is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0002193 ! myelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:15Z [Term] id: CL:0002193 name: myelocyte namespace: cell def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [GOC:tfm, http://en.wikipedia.org/wiki/Myelocyte, ISBN:0323052908] xref: BTO:0000734 xref: FMA:83525 is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:19Z [Term] id: CL:0002194 name: monopoietic cell namespace: cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] xref: FMA:83552 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0030224 ! monocyte differentiation relationship: capable_of GO:0030224 ! monocyte differentiation created_by: tmeehan creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002195 name: hepatic stem cell namespace: cell def: "A stem cell that can give rise to the cells of the liver." [GOC:tfm] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell namespace: cell alt_id: CL:1000036 def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [PMID:17901986] synonym: "hepatic oval cell" EXACT [] xref: BTO:0004270 xref: FMA:86576 is_a: CL:0002195 ! hepatic stem cell created_by: tmeehan creation_date: 2010-08-30T02:01:49Z [Term] id: CL:0002197 name: inactive chief cell of parathyoid gland namespace: cell def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [GOC:tfm, ISBN:0517223651] is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:14:01Z [Term] id: CL:0002198 name: oncocyte namespace: cell def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317] synonym: "oxyphil" EXACT [] xref: FMA:67606 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T11:26:49Z [Term] id: CL:0002199 name: oxyphil cell of parathyroid gland namespace: cell def: "An oncocyte located in the parathyroid gland." [PMID:20013317] xref: FMA:69084 is_a: CL:0002198 ! oncocyte is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:23Z [Term] id: CL:0002200 name: oxyphil cell of thyroid namespace: cell def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317] synonym: "Askanazy cells" EXACT [] synonym: "Hurthle cells" EXACT [] xref: FMA:87169 is_a: CL:0002198 ! oncocyte is_a: CL:0002257 ! epithelial cell of thyroid gland intersection_of: CL:0002198 ! oncocyte intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:26Z [Term] id: CL:0002201 name: renal beta-intercalated cell namespace: cell def: "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." [GOC:tfm, PMID:11781354] is_a: CL:0005010 ! renal intercalated cell created_by: tmeehan creation_date: 2010-09-02T01:43:55Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree namespace: cell alt_id: CL:1000407 def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002203 name: Brush cell of epithelium proper of large intestine namespace: cell alt_id: CL:1000387 def: "Brush cell found in the epithelial layer of the colon." [GOC:tfm] comment: Brush cells are a distinct cell type from brush border cell-types. xref: FMA:263222 is_a: CL:0002204 ! brush cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-02T02:20:50Z [Term] id: CL:0002204 name: brush cell namespace: cell def: "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "caveolated cell" EXACT [] synonym: "fibrillovesicular cell" EXACT [] synonym: "multivesicular cell" EXACT [] synonym: "tuft cell" EXACT [] xref: FMA:67978 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:28:53Z [Term] id: CL:0002205 name: brush cell of lobular bronchiole namespace: cell alt_id: CL:1000386 def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm] xref: FMA:263220 is_a: CL:0002208 ! brush cell of bronchus intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole created_by: tmeehan creation_date: 2010-09-02T02:38:34Z [Term] id: CL:0002206 name: brush cell of terminal bronchiole namespace: cell alt_id: CL:1000390 def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm] xref: FMA:263228 is_a: CL:0000082 {is_inferred="true"} ! epithelial cell of lung is_a: CL:0002205 ! brush cell of lobular bronchiole intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium created_by: tmeehan creation_date: 2010-09-02T02:38:36Z [Term] id: CL:0002207 name: brush cell of trachea namespace: cell alt_id: CL:1000388 def: "Brush cell of the epithelium in the trachea." [GOC:tfm] xref: FMA:263224 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea created_by: tmeehan creation_date: 2010-09-02T02:38:37Z [Term] id: CL:0002208 name: brush cell of bronchus namespace: cell alt_id: CL:1000389 def: "A brush cell found in the epithelium of bronchus." [GOC:tfm] xref: FMA:263226 is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus created_by: tmeehan creation_date: 2010-09-02T02:38:42Z [Term] id: CL:0002209 name: intermediate epitheliocyte namespace: cell def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002210 name: red muscle cell namespace: cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651] synonym: "oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] xref: FMA:84448 is_a: CL:0008002 ! skeletal muscle fiber created_by: tmeehan creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell namespace: cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651] synonym: "intermediate muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "slow twitch fiber" EXACT [] synonym: "slow twitch muscle cell" EXACT [] synonym: "slow twitch muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "slow-twitch muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: BTO:0001812 xref: CALOHA:TS-0940 xref: FMA:84413 xref: MESH:A02.633.565.700 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell created_by: tmeehan creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell namespace: cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm] synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] synonym: "type II muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84414 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell namespace: cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651] xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell namespace: cell def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm] synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] synonym: "type 2a muscle cell" EXACT [] synonym: "type 2a muscle fiber" EXACT [] synonym: "type IIa muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84415 is_a: CL:0002210 ! red muscle cell is_a: CL:0002212 ! type II muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell namespace: cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651] synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] synonym: "type IIb muscle fiber" EXACT [] xref: FMA:84416 is_a: CL:0002212 ! type II muscle cell is_a: CL:0002213 ! white muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002216 name: intermediate muscle cell namespace: cell def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [GOC:tfm] xref: FMA:84450 is_a: CL:0008002 ! skeletal muscle fiber created_by: tmeehan creation_date: 2010-09-02T03:51:17Z [Term] id: CL:0002217 name: intermediate trophoblast cell namespace: cell def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] xref: BTO:0002366 xref: FMA:86564 is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:04:36Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002219 name: anchoring trophoblast namespace: cell def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:14:28Z [Term] id: CL:0002220 name: interstitial cell of pineal gland namespace: cell def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002221 name: keratinized squamous cell of esophagus namespace: cell def: "A squamous cell that has keratin in the esophagus." [GOC:tfm, PMID:11694559] xref: FMA:86549 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2010-09-07T10:11:06Z [Term] id: CL:0002222 name: vertebrate lens cell namespace: cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0000965 ! lens of camera-type eye created_by: tmeehan creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell namespace: cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [GOC:tfm, ISBN:0517223651] xref: FMA:63181 is_a: CL:0002224 ! lens epithelial cell created_by: tmeehan creation_date: 2010-09-07T10:45:45Z [Term] id: CL:0002224 name: lens epithelial cell namespace: cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] xref: FMA:67559 is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: part_of UBERON:0001803 ! epithelium of lens relationship: part_of UBERON:0001803 ! epithelium of lens created_by: tmeehan creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber namespace: cell def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651] synonym: "secondary lens fibre" EXACT [] is_a: CL:0011004 ! lens fiber cell relationship: develops_from CL:0002228 ! primary lens fiber created_by: tmeehan creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002226 name: non-nucleated secondary lens fiber namespace: cell def: "A secondary lens fiber cell that lacks a nucleus." [GOC:tfm] synonym: "non-nucleated secondary lens fibre" EXACT [] xref: FMA:67561 is_a: CL:0002225 ! secondary lens fiber relationship: develops_from CL:0002227 ! nucleated secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:23Z [Term] id: CL:0002227 name: nucleated secondary lens fiber namespace: cell def: "A secondary fiber cell that contains a nucleus." [GOC:tfm] synonym: "nucleated secondary lens fibre" EXACT [] xref: FMA:70949 is_a: CL:0002225 ! secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:26Z [Term] id: CL:0002228 name: primary lens fiber namespace: cell def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704] synonym: "primary lens fibre" EXACT [] xref: FMA:70613 is_a: CL:0011004 ! lens fiber cell relationship: develops_from CL:0002223 ! anterior lens cell created_by: tmeehan creation_date: 2010-09-07T11:19:01Z [Term] id: CL:0002229 name: light chief cell of parathyroid gland namespace: cell def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69079 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-07T11:46:54Z [Term] id: CL:0002231 name: epithelial cell of prostate namespace: cell alt_id: CL:1000295 alt_id: CL:1000408 def: "An epithelial cell of the prostate." [GOC:tfm] synonym: "prostate epithelial cell" EXACT [] xref: FMA:256163 xref: FMA:66817 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-07T01:49:29Z [Term] id: CL:0002232 name: epithelial cell of prostatic duct namespace: cell alt_id: CL:1000462 def: "An epithelial cell of prostatic duct." [GOC:tfm] synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224] xref: FMA:74224 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:55:51Z [Term] id: CL:0002233 name: epithelial cell of prostatic acinus namespace: cell alt_id: CL:1000461 def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349] synonym: "acinar epithelial cell of prostate" EXACT [FMA:74223] xref: FMA:74223 is_a: CL:0002231 {is_inferred="true"} ! epithelial cell of prostate intersection_of: CL:0002231 ! epithelial cell of prostate intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:55:53Z [Term] id: CL:0002234 name: basal cell of prostatic acinus namespace: cell alt_id: CL:1000464 def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm] synonym: "basal epithelial cell of prostatic acinus" EXACT [FMA:74265] xref: FMA:74265 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:59:08Z [Term] id: CL:0002235 name: luminal cell of prostatic acinus namespace: cell def: "A cell of the luminal layer of the epithelium in the prostatic acinus." [GOC:tfm] xref: FMA:74266 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:59:10Z [Term] id: CL:0002236 name: basal epithelial cell of prostatic duct namespace: cell alt_id: CL:1000463 def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377] xref: FMA:74226 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:12Z [Term] id: CL:0002237 name: luminal epithelial cell of prostatic duct namespace: cell def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [GOC:tfm] xref: FMA:74225 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:16Z [Term] id: CL:0002238 name: male gonocyte namespace: cell def: "A primordial germ cell that is destined to become a male germ cell." [GOC:tfm] synonym: "male primordial germ cell" EXACT [] synonym: "testis primordial germ cell" EXACT [VHOG:0000662] xref: EHDAA2:0001053 xref: EMAPA:18686 xref: FMA:84771 xref: VHOG:0000662 is_a: CL:0000670 ! primordial germ cell relationship: part_of UBERON:0000473 ! testis created_by: tmeehan creation_date: 2010-09-07T02:11:13Z [Term] id: CL:0002239 name: ooblast namespace: cell def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [GOC:tfm] synonym: "ovary primordial germ cell" EXACT [VHOG:0000661] synonym: "ovigerm" EXACT [FMA:84772] xref: EHDAA2:0000505 xref: EMAPA:17965 xref: FMA:84772 xref: ISBN:0721662544 xref: VHOG:0000661 is_a: CL:0000670 ! primordial germ cell relationship: part_of UBERON:0000992 ! female gonad created_by: tmeehan creation_date: 2010-09-07T02:11:16Z [Term] id: CL:0002240 name: marrow fibroblast namespace: cell def: "A fibroblast in the bone marrow." [GOC:tfm] xref: FMA:84377 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002241 name: pulmonary interstitial fibroblast namespace: cell def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] synonym: "pulmonary myofibroblast" EXACT [] synonym: "pulmonary septal cell" EXACT [] xref: FMA:84467 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001004 ! respiratory system intersection_of: part_of UBERON:0005169 ! interstitial tissue relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0005169 ! interstitial tissue created_by: tmeehan creation_date: 2010-09-07T02:29:38Z [Term] id: CL:0002242 name: nucleate cell namespace: cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil namespace: cell def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001607 ! sphincter pupillae relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001607 ! sphincter pupillae created_by: tmeehan creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002244 name: squamous cell of ectocervix namespace: cell def: "A nonstratified squamous cell located in the ectocervix." [GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm] synonym: "ectocervical squamous cell" EXACT [] xref: FMA:86483 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-09-08T09:12:23Z [Term] id: CL:0002245 name: obsolete null lymphocyte namespace: cell def: "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." [GOC:tfm, ISBN:068340007X] xref: FMA:83601 is_obsolete: true created_by: tmeehan creation_date: 2010-09-07T03:43:42Z [Term] id: CL:0002246 name: peripheral blood stem cell namespace: cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood created_by: tmeehan creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002247 name: pleural macrophage namespace: cell def: "A tissue macrophage that is in the pleural space." [GOC:tfm] xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002248 name: pluripotent stem cell namespace: cell def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID:19343304] xref: FMA:70570 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-07T04:26:06Z [Term] id: CL:0002249 name: primitive cardiac myocyte namespace: cell def: "A stem cell that can differentiate into a cardiac myocyte." [GOC:tfm, PMID:16938308] xref: FMA:75620 is_a: CL:0000035 ! single fate stem cell is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-07T04:40:32Z [Term] id: CL:0002250 name: intestinal crypt stem cell namespace: cell def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells." [GOC:tfm, ISBN:0517223651] synonym: "stem cell of intestinal crypt of lieberkuhn" EXACT [] xref: FMA:63379 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn created_by: tmeehan creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal namespace: cell def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract created_by: tmeehan creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus namespace: cell alt_id: CL:1000402 def: "An epithelial cell of the esophagus." [GOC:tfm] xref: FMA:63071 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine namespace: cell alt_id: CL:1000292 def: "An epithelial cell of the large intestine." [GOC:tfm] synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine namespace: cell alt_id: CL:1000293 def: "An epithelial cell of the small intestine." [GOC:tfm] xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002255 name: stromal cell of endometrium namespace: cell def: "An epithelial cell that regulates growth and differentiation of the overlying epithelium." [GOC:tfm, PMID:11331626] xref: CALOHA:TS-1266 xref: FMA:86490 is_a: CL:0000499 {is_inferred="true"} ! stromal cell is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2010-09-08T09:50:04Z [Term] id: CL:0002256 name: supporting cell of carotid body namespace: cell def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136] synonym: "carotid body sustentacular cell" EXACT [] xref: FMA:84188 is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-08T10:34:45Z [Term] id: CL:0002257 name: epithelial cell of thyroid gland namespace: cell alt_id: CL:1000297 def: "An epithelial cell of thyroid gland." [GOC:tfm] xref: FMA:256167 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:46:51Z [Term] id: CL:0002258 name: thyroid follicular cell namespace: cell def: "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." [GOC:tfm, ISBN:0517223651] synonym: "follicular cell of thyroid gland" EXACT [] synonym: "principal cell of thyroid gland" EXACT [] synonym: "thyroid gland follicular cell" EXACT [] xref: BTO:0003736 xref: CALOHA:TS-1285 xref: FMA:68782 is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:50:08Z [Term] id: CL:0002259 name: neuroepithelial stem cell namespace: cell def: "The stem cell from which glial precursor cell arises from." [GOC:tfm, PMID:11687496] synonym: "totipotent neuroepithelial stem cell" NARROW [] xref: FMA:87171 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-08T02:14:14Z [Term] id: CL:0002260 name: epithelial cell of parathyroid gland namespace: cell alt_id: CL:1000429 def: "An epithelial cell of the parathyroid gland." [GOC:tfm] xref: FMA:70547 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell is_a: CL:1001593 ! parathyroid glandular cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0001132 ! parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:29:38Z [Term] id: CL:0002261 name: endothelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000446 def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256] xref: FMA:70627 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-14T10:40:12Z [Term] id: CL:0002262 name: endothelial cell of sinusoid namespace: cell alt_id: CL:1000403 def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] xref: FMA:63134 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid created_by: tmeehan creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002263 name: transitional cell of parathyroid gland namespace: cell def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [GOC:tfm, ISBN:0412046911] xref: FMA:69324 is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:33:50Z [Term] id: CL:0002264 name: type A cell of stomach namespace: cell def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] xref: FMA:83411 is_a: CL:0002067 ! type A enterocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enterocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon namespace: cell def: "A D cell located in the colon." [GOC:tfm] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon created_by: tmeehan creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine namespace: cell def: "A type D cell of the small intestine." [GOC:tfm] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach namespace: cell def: "A type D cell found in the stomach." [GOC:tfm] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002268 name: P/D1 enteroendocrine cell namespace: cell def: "An enteroendocrine cell that stores and secretes Ghrelin." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63207 xref: FMA:63418 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell created_by: tmeehan creation_date: 2010-09-10T01:47:45Z [Term] id: CL:0002269 name: vasoactive intestinal peptide secreting cell namespace: cell def: "An endocrine cell that secretes vasoactive intestinal peptide." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T01:52:20Z [Term] id: CL:0002270 name: type EC2 enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:62941 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell created_by: tmeehan creation_date: 2010-09-10T02:13:47Z [Term] id: CL:0002271 name: type EC1 enteroendocrine cell namespace: cell def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651] xref: FMA:62940 is_a: CL:0000505 ! substance P secreting cell is_a: CL:0000577 ! type EC enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T02:13:49Z [Term] id: CL:0002272 name: motilin secreting cell namespace: cell def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [GOC:tfm, MESH:D06.472.317.525] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T02:31:13Z [Term] id: CL:0002273 name: type ECL enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63208 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell created_by: tmeehan creation_date: 2010-09-10T02:35:17Z [Term] id: CL:0002274 name: histamine secreting cell namespace: cell def: "A cell type that secretes histamine." [GOC:tfm] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0001821 ! histamine secretion relationship: capable_of GO:0001821 ! histamine secretion created_by: tmeehan creation_date: 2010-09-10T03:04:42Z [Term] id: CL:0002275 name: pancreatic PP cell namespace: cell def: "A PP cell located in the islets of the pancreas." [GOC:tfm] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000696 ! PP cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002276 name: obsolete PP cell of pancreatic acinus namespace: cell def: "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." [GOC:tfm] synonym: "type F cell of pancreatic acinus" EXACT [] xref: FMA:85400 is_obsolete: true created_by: tmeehan creation_date: 2010-09-10T03:30:33Z [Term] id: CL:0002277 name: type I enteroendocrine cell namespace: cell def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [GOC:tfm] synonym: "CCK cell" EXACT [] xref: FMA:62937 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:44:36Z [Term] id: CL:0002278 name: GIP cell namespace: cell def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [GOC:tfm] synonym: "type K enteroendocrine cell" EXACT [] xref: FMA:62942 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:51:47Z [Term] id: CL:0002279 name: type L enteroendocrine cell namespace: cell def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [ISBN:0517223651, PMID:15153415] xref: FMA:62944 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:59:09Z [Term] id: CL:0002280 name: type N enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." [GOC:tfm] synonym: "N cell" EXACT [] xref: FMA:62943 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T04:08:29Z [Term] id: CL:0002281 name: type S enteroendocrine cell namespace: cell def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [GOC:tfm, PMID:15153415] xref: FMA:62936 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000458 ! serotonin secreting cell created_by: tmeehan creation_date: 2010-09-10T04:44:46Z [Term] id: CL:0002282 name: type TG enteroendocrine cell namespace: cell def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [DOI:10.1007/978-3-211-99390-3, GOC:tfm, PMID:7013499] xref: FMA:63421 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000509 ! gastrin secreting cell created_by: tmeehan creation_date: 2010-09-13T09:48:34Z [Term] id: CL:0002283 name: ecto-epithelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000440 def: "An epithelial cell of the mucosa associated with facial skeleton." [GOC:tfm, ISBN:0323052908] xref: FMA:70581 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:04:02Z [Term] id: CL:0002284 name: type X enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." [GOC:tfm, PMID:20616512] synonym: "A-like" EXACT [] synonym: "X/A-like" EXACT [] xref: FMA:63209 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0005018 ! ghrelin secreting cell created_by: tmeehan creation_date: 2010-09-13T10:12:12Z [Term] id: CL:0002285 name: type III taste bud cell namespace: cell def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [GOC:tfm, ISBN:0517223651, PMID:15738192] synonym: "taste bud basal cell" BROAD [] synonym: "type 3 taste cell" EXACT [] xref: FMA:67940 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:21Z [Term] id: CL:0002286 name: type II taste cell namespace: cell def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [GOC:tfm, PMID:15738192] synonym: "type 2 taste cell" EXACT [] xref: FMA:62381 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:26Z [Term] id: CL:0002287 name: type IV taste receptor cell namespace: cell def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [GOC:tfm, ISBN:0517223651, PMID:15738192] comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192. synonym: "taste bud basal cell" BROAD [] synonym: "type 4 taste cell" EXACT [] xref: FMA:62380 is_a: CL:0000034 ! stem cell is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:29Z [Term] id: CL:0002288 name: type V taste receptor cell namespace: cell def: "A cell type that forms the boundary with the surrounding epithelium." [GOC:tfm, ISBN:0517223651] xref: FMA:67941 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:31Z [Term] id: CL:0002289 name: type I taste bud cell namespace: cell def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:15738192] synonym: "dark tongue cell" EXACT [] synonym: "type I taste cell" EXACT [] synonym: "type taste 1 cell" EXACT [] xref: FMA:62356 is_a: CL:0000209 ! taste receptor cell is_a: CL:0000703 ! sustentacular cell created_by: tmeehan creation_date: 2010-09-13T10:57:35Z [Term] id: CL:0002290 name: Y chromosome-bearing sperm cell namespace: cell def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "Y bearing sperm" EXACT [] synonym: "Y-bearing sperm" EXACT [] xref: FMA:84058 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:24Z [Term] id: CL:0002291 name: X chromosome-bearing sperm cell namespace: cell def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "X bearing sperm" EXACT [] synonym: "X-bearing sperm" EXACT [] xref: FMA:84057 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:26Z [Term] id: CL:0002292 name: type I cell of carotid body namespace: cell def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651] synonym: "glomus cell" EXACT [] xref: FMA:84186 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-13T01:40:21Z [Term] id: CL:0002293 name: epithelial cell of thymus namespace: cell alt_id: CL:1000459 def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: CALOHA:TS-1040 xref: FMA:72208 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus namespace: cell def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335] synonym: "subcapsular thymic epithelial cell" EXACT [] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [GOC:tfm, PMID:19721455, PMID:9264335] synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus namespace: cell def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [FMA:0412046911, GOC:tfm, PMID:9264335] synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [PMID:9264335] synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [GOC:tfm, ISBN:0412046911, PMID:19721455, PMID:9264335] synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus namespace: cell def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [GOC:tfm, ISBN:0412046911, PMID:9264335] synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus namespace: cell def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [GOC:tfm, PMID:19721455] synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002301 name: type B synovial cell namespace: cell def: "A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." [GOC:tfm, ISBN:0517223651] xref: FMA:66788 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:14Z [Term] id: CL:0002302 name: type A synovial cell namespace: cell def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [GOC:tfm, ISBN:0517223651] synonym: "type A synoviocyte" EXACT [] xref: FMA:66787 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:17Z [Term] id: CL:0002303 name: pigmented ciliary epithelial cell namespace: cell def: "A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells." [PMID:15106942] synonym: "PE" EXACT [] xref: FMA:70606 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000529 ! pigmented epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:27Z [Term] id: CL:0002304 name: non-pigmented ciliary epithelial cell namespace: cell def: "A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells." [GOC:tfm, PMID:15106942] synonym: "NPE" EXACT [] xref: FMA:70607 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:31Z [Term] id: CL:0002305 name: epithelial cell of distal tubule namespace: cell def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651] synonym: "kidney distal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70981 xref: KUPO:0001055 is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004135 ! distal tubule relationship: part_of UBERON:0004135 ! distal tubule [Term] id: CL:0002306 name: epithelial cell of proximal tubule namespace: cell def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3] synonym: "kidney proximal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70973 xref: KUPO:0001044 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004134 ! proximal tubule relationship: part_of UBERON:0004134 ! proximal tubule [Term] id: CL:0002307 name: brush border cell of the proximal tubule namespace: cell def: "A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow." [GOC:tfm, ISBN:1-4160-2328-3] is_a: CL:0002306 ! epithelial cell of proximal tubule created_by: tmeehan creation_date: 2010-09-14T11:29:20Z [Term] id: CL:0002308 name: epithelial cell of skin gland namespace: cell def: "An epithelial cell of a skin gland." [GOC:tfm] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002419 ! skin gland relationship: part_of UBERON:0002419 ! skin gland created_by: tmeehan creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002309 name: corticotroph namespace: cell def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [GOC:tfm, ISBN:0517223651] xref: BTO:0002509 xref: FMA:83098 is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:08:23Z [Term] id: CL:0002310 name: mammosomatotroph namespace: cell def: "An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone." [GOC:tfm] xref: FMA:83097 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:25:34Z [Term] id: CL:0002311 name: mammotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl] synonym: "epsilon-acidophil" EXACT [] synonym: "lactotrope" EXACT [] synonym: "lactotroph" EXACT [] synonym: "lactotropic cell" EXACT [] synonym: "mammotrope" EXACT [] synonym: "mammotrophic cell" EXACT [] synonym: "mammotropic cell" EXACT [] xref: FMA:83096 is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:30:57Z [Term] id: CL:0002312 name: somatotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] synonym: "somatotrope" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland namespace: cell def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm] synonym: "glandular cell of prostate" EXACT [] synonym: "neuro-epithelial cell of prostate gland" EXACT [] xref: CALOHA:TS-1280 xref: FMA:74390 xref: FMA:86774 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: capable_of GO:0046879 ! hormone secretion intersection_of: part_of UBERON:0002367 ! prostate gland relationship: capable_of GO:0046879 ! hormone secretion relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-14T03:01:58Z [Term] id: CL:0002314 name: external supporting cell of vestibular epithelium namespace: cell def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [GOC:tfm, PMID:20837532] xref: FMA:75809 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:20:01Z [Term] id: CL:0002315 name: supporting cell of cochlea namespace: cell def: "An epithelial supporting cell located in the cochlea." [GOC:tfm] xref: FMA:79796 is_a: CL:0005014 ! auditory epithelial support cell intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0001844 ! cochlea relationship: part_of UBERON:0001844 ! cochlea created_by: tmeehan creation_date: 2010-09-14T03:31:38Z [Term] id: CL:0002316 name: supporting cell of vestibular epithelium namespace: cell def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532] xref: FMA:75607 is_a: CL:0005014 ! auditory epithelial support cell intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0001862 ! vestibular labyrinth relationship: part_of UBERON:0001862 ! vestibular labyrinth created_by: tmeehan creation_date: 2010-09-14T03:31:44Z [Term] id: CL:0002317 name: external limiting cell of vestibular epithelium namespace: cell def: "An external limiting cell found in the vestibular epithelium." [GOC:tfm] xref: FMA:75808 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:33:50Z [Term] id: CL:0002318 name: periperhal blood mesothelial cell namespace: cell def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528] xref: FMA:86712 is_a: CL:0000081 ! blood cell relationship: develops_from CL:0000077 ! mesothelial cell created_by: tmeehan creation_date: 2010-09-15T10:47:11Z [Term] id: CL:0002319 name: neural cell namespace: cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system created_by: tmeehan creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell namespace: cell alt_id: CL:1000406 def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2096 xref: FMA:63875 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue created_by: tmeehan creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell namespace: cell def: "A cell of the embryo." [FMA:0618947256] xref: CALOHA:TS-0263 xref: FMA:82840 xref: FMA:82841 xref: WBbt:0007028 is_a: CL:0000548 ! animal cell created_by: tmeehan creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002322 name: embryonic stem cell namespace: cell def: "A stem cell of embryonic origin." [GOC:dsd, GOC:tfm, ISBN:068340007X, PMID:18179856] comment: This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive. synonym: "ESC" EXACT [] xref: BTO:0001086 xref: CALOHA:TS-0263 xref: FMA:82841 is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell created_by: tmeehan creation_date: 2010-09-15T03:44:35Z [Term] id: CL:0002323 name: amniocyte namespace: cell def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847] xref: BTO:0000066 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: RO:0001025 UBERON:0000173 ! amniotic fluid relationship: RO:0001025 UBERON:0000173 ! amniotic fluid created_by: tmeehan creation_date: 2010-09-20T10:13:37Z [Term] id: CL:0002324 name: myoepithelial cell of mammary gland namespace: cell def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [GOC:tfm, PMID:11250738, PMID:19022771] is_a: CL:1000416 ! myoepithelial cell of lactiferous gland created_by: tmeehan creation_date: 2010-09-20T11:42:14Z [Term] id: CL:0002325 name: mammary alveolar cell namespace: cell alt_id: CL:0002230 alt_id: CL:1000476 def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771] synonym: "epithelial cell of lactiferous gland" EXACT [] synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] xref: FMA:74506 xref: FMA:79866 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000314 ! milk secreting cell is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0003214 ! mammary gland alveolus relationship: part_of UBERON:0003214 ! mammary gland alveolus created_by: tmeehan creation_date: 2010-09-20T01:30:57Z [Term] id: CL:0002326 name: luminal epithelial cell of mammary gland namespace: cell def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771] xref: FMA:73280 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:37:53Z [Term] id: CL:0002327 name: mammary gland epithelial cell namespace: cell def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771] synonym: "breast epithelial cell" EXACT [] synonym: "mammary epithelial cell" EXACT [] xref: BTO:0004300 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2010-09-20T01:49:37Z [Term] id: CL:0002328 name: bronchial epithelial cell namespace: cell def: "An epithelial cell of the bronchus." [GOC:tfm] xref: BTO:0002922 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree namespace: cell def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:10:36Z [Term] id: CL:0002330 name: undifferentiated cell of bronchus epithelium namespace: cell def: "An undifferentiated columnar cell of the bronchus epithelium" [GOC:tfm, PMID:18757316] is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-20T02:17:58Z [Term] id: CL:0002332 name: ciliated cell of the bronchus namespace: cell def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:21:12Z [Term] id: CL:0002333 name: neural crest derived fat cell namespace: cell def: "A fat cell derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000005 ! fibroblast neural crest derived relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte namespace: cell def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119] xref: BTO:0001107 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte namespace: cell def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2010-09-20T02:38:38Z [Term] id: CL:0002336 name: buccal mucosa cell namespace: cell def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:A10.615.550.599] is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2010-09-20T02:52:54Z [Term] id: CL:0002337 name: keratinocyte stem cell namespace: cell def: "A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair." [PMID:15339667] synonym: "bulge keratinocyte" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-09-20T03:07:03Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002339 name: prostate stem cell namespace: cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377] synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-20T03:21:06Z [Term] id: CL:0002340 name: luminal cell of prostate epithelium namespace: cell def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [GOC:tfm] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:05Z [Term] id: CL:0002341 name: basal cell of prostate epithelium namespace: cell def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:10Z [Term] id: CL:0002342 name: circulating endothelial cell namespace: cell def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [GOC:tfm, PMID:19652886] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-20T03:49:58Z [Term] id: CL:0002343 name: decidual natural killer cell namespace: cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000009766 ! galectin-1 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000009766 ! galectin-1 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 created_by: tmeehan creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422] comment: Markers are associated with mouse cells. synonym: "preNK.BM" BROAD [] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: has_plasma_membrane_part PR:000001008 ! integrin alpha-2 intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48 relationship: develops_from CL:0002346 ! Dx5-negative, NK1.1-positive immature natural killer cell relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48 created_by: tmeehan creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 created_by: tmeehan creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell namespace: cell def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: capable_of GO:0032609 ! interferon-gamma production intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: capable_of GO:0032609 ! interferon-gamma production relationship: develops_from CL:0002349 ! CD27-high, CD11b-low natural killer cell relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell namespace: cell def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: develops_from CL:0002347 ! CD27-high, CD11b-high natural killer cell relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell namespace: cell def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: develops_from CL:0002345 ! CD27-low, CD11b-low immature natural killer cell relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002350 name: endocardial cell namespace: cell alt_id: CL:1000475 def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium created_by: tmeehan creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas namespace: cell def: "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494] synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell namespace: cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764] is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: has_plasma_membrane_part GO:0042611 ! MHC protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: has_plasma_membrane_part GO:0042611 ! MHC protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell namespace: cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: part_of UBERON:0001040 ! yolk sac created_by: tmeehan creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell namespace: cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: has_part PR:000008467 ! hemoglobin subunit zeta intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1 intersection_of: part_of UBERON:0000922 ! embryo relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002361 ! primitive erythroid progenitor relationship: has_part PR:000008467 ! hemoglobin subunit zeta relationship: has_part PR:000008857 ! hemoglobin subunit beta-1 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002356 name: primitive reticulocyte namespace: cell def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "megalocyte" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: develops_from CL:0002355 ! primitive red blood cell relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T09:35:16Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte namespace: cell def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698] synonym: "macrocyte" EXACT [] is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1 intersection_of: part_of UBERON:0000922 ! embryo relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor cell relationship: has_part PR:000008857 ! hemoglobin subunit beta-1 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:38:32Z [Term] id: CL:0002358 name: pyrenocyte namespace: cell def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [GOC:tfm] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000587 ! decreased size intersection_of: develops_from CL:0002355 ! primitive red blood cell relationship: bearer_of PATO:0000587 ! decreased size relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T10:02:37Z [Term] id: CL:0002359 name: placental hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2010-09-22T10:30:02Z [Term] id: CL:0002360 name: AGM hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:31:49Z [Term] id: CL:0002361 name: primitive erythroid progenitor namespace: cell def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002418 ! hemangioblast relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-09-22T10:47:28Z [Term] id: CL:0002362 name: granule cell precursor namespace: cell def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [GOC:tfm, PMID:14745007] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) created_by: tmeehan creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte namespace: cell def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5] synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! fibroblast neural crest derived intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001777 ! substantia propria of cornea created_by: tmeehan creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002364 name: cortical thymic epithelial cell namespace: cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190] synonym: "cTEC" EXACT [] xref: BTO:0004562 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell namespace: cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458] synonym: "mTEC" EXACT [] xref: BTO:0004563 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002366 name: myometrial cell namespace: cell def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640] synonym: "myometrium smooth muscle cell" EXACT [] xref: BTO:0004519 is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001296 ! myometrium relationship: part_of UBERON:0001296 ! myometrium created_by: tmeehan creation_date: 2010-09-23T03:46:34Z [Term] id: CL:0002367 name: trabecular meshwork cell namespace: cell def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [GOC:tfm, PMID:14500801] synonym: "trabeculocyte" EXACT [] is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0005969 ! eye trabecular meshwork relationship: part_of UBERON:0005969 ! eye trabecular meshwork created_by: tmeehan creation_date: 2010-09-23T04:18:50Z [Term] id: CL:0002368 name: respiratory epithelial cell namespace: cell def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] synonym: "airway epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract created_by: tmeehan creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore namespace: cell def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002370 name: respiratory goblet cell namespace: cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544] synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863] is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0004802 ! respiratory tract epithelium created_by: tmeehan creation_date: 2010-09-23T04:42:27Z [Term] id: CL:0002371 name: somatic cell namespace: cell def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544] subset: ubprop:upper_level xref: BTO:0001268 xref: FMA:72300 xref: WBbt:0008378 is_a: CL:0000003 ! native cell created_by: tmeehan creation_date: 2010-09-24T09:44:42Z [Term] id: CL:0002372 name: myotube namespace: cell alt_id: CL:0000369 def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] synonym: "myotubule" EXACT [] synonym: "single cell sarcomere" EXACT [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: has_part GO:0030017 ! sarcomere created_by: tmeehan creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002373 name: growth hormone releasing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [GOC:dph, GOC:tfm] synonym: "GHRH secreting cell" EXACT [] synonym: "somatocrinin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-24T01:36:44Z [Term] id: CL:0002374 name: ear hair cell namespace: cell def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023] synonym: "ear receptor cell" EXACT [] is_a: CL:0000855 ! sensory hair cell created_by: tmeehan creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor namespace: cell def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm] synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0000030 ! glioblast relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002376 name: non-myelinating Schwann cell namespace: cell def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell created_by: tmeehan creation_date: 2010-09-24T02:10:26Z [Term] id: CL:0002377 name: immature Schwann cell namespace: cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] xref: ZFA:0001725 is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002375 ! Schwann cell precursor created_by: tmeehan creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002379 name: meningothelial cell namespace: cell def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [GOC:tfm, http://www.aippg.net/forum/viewtopic.php?t=62590] synonym: "arachnoid cap cell" EXACT [] xref: FMA:86588 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-28T02:23:46Z [Term] id: CL:0002380 name: oospore namespace: cell def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [GOC:tfm, ISBN:0851988857, SGD:clt] xref: FAO:0000039 is_a: CL:0000605 ! fungal asexual spore created_by: tmeehan creation_date: 2010-10-01T09:22:45Z [Term] id: CL:0002381 name: uninucleate conidium namespace: cell def: "A conidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000025 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:26:39Z [Term] id: CL:0002382 name: multinucleate conidium namespace: cell def: "A conidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000033 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:31:28Z [Term] id: CL:0002383 name: conidium of conidiophore head namespace: cell def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [GOC:tfm, PMID:9529886, SGD:clt] xref: FAO:0000033 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002384 name: uninucleate macroconidium namespace: cell def: "A macroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000029 is_a: CL:0000606 ! macroconidium is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002385 name: blastoconidium namespace: cell def: "An oblong or round asexual spore formed from conidial chains." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "blastospore" RELATED [] xref: BTO:0000127 xref: FAO:0000042 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002386 name: multinucleate macroconidium namespace: cell def: "A macroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000035 is_a: CL:0000606 ! macroconidium is_a: CL:0002382 ! multinucleate conidium [Term] id: CL:0002387 name: arthroconidium namespace: cell def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "arthrospore" RELATED [] xref: FAO:0000041 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002388 name: multinucleate arthroconidium namespace: cell def: "An arthroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000037 is_a: CL:0002386 ! multinucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002389 name: uninucleate arthroconidium namespace: cell def: "An arthroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000031 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002390 name: uninucleate blastconidium namespace: cell def: "A blastoconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000030 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002385 ! blastoconidium [Term] id: CL:0002391 name: multinucleate blastoconidium namespace: cell def: "A blastoconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000036 is_a: CL:0002385 ! blastoconidium is_a: CL:0002386 ! multinucleate macroconidium [Term] id: CL:0002392 name: obsolete plant spore namespace: cell def: "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." [GOC:tfm, PO:0025017] comment: replaced_by: PO:0025017 is_obsolete: true [Term] id: CL:0002393 name: intermediate monocyte namespace: cell def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_not_completed GO:0030224 ! monocyte differentiation intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: develops_from CL:0000860 ! classical monocyte relationship: has_not_completed GO:0030224 ! monocyte differentiation relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 created_by: tmeehan creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [GOC:dsd, GOC:tfm, PMCID:PMC2882828, PMCID:PMC2882837, PMID:17332250, PMID:20628149] comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs. is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response intersection_of: capable_of GO:0032606 ! type I interferon production intersection_of: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I intersection_of: has_plasma_membrane_part PR:000002105 ! thrombomodulin relationship: capable_of GO:0002827 ! positive regulation of T-helper 1 type immune response relationship: capable_of GO:0032606 ! type I interferon production relationship: capable_of GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: has_plasma_membrane_part PR:000002105 ! thrombomodulin created_by: tmeehan creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:20628149, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin created_by: tmeehan creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte namespace: cell def: "A patrolling monocyte that is CD14-low and CD16-positive." [GOC:tfm, PMID:20870168] comment: Markers are associated with human monocytes. synonym: "non-classical monocyte, human" EXACT [] is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0002397 ! CD14-positive, CD16-positive monocyte relationship: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte namespace: cell def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). synonym: "CD16+ monocyte" EXACT [PMID:22343568] is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001199 ! C-C chemokine receptor type 2 created_by: tmeehan creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte namespace: cell def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: develops_from CL:0002395 ! Gr1-high classical monocyte relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 created_by: tmeehan creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD1c-positive." [GOC:dsd, GOC:tfm, PMID:20204387, PMID:20628149] comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: capable_of GO:0032637 ! interleukin-8 production intersection_of: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c relationship: capable_of GO:0032637 ! interleukin-8 production relationship: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c created_by: tmeehan creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: Fraction B/C precursor B cell namespace: cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex created_by: tmeehan creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002218 ! immature dendritic epithelial T cell precursor created_by: tmeehan creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell namespace: cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: part_of UBERON:0001211 ! Peyer's patch created_by: tmeehan creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002378 ! immature Vgamma2-positive fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte namespace: cell def: "A thymocyte found in the fetal thymus." [GOC:tfm] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte namespace: cell def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [GOC:tfm, PMID:20725107] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 created_by: tmeehan creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002406 ! immature Vgamma2-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002408 ! immature Vgamma2-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002410 name: pancreatic stellate cell namespace: cell def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [GOC:mah, GOC:tfm, PMID:17200706] synonym: "PaSC" EXACT [] is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2010-11-10T09:40:33Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org] synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002417 name: primitive erythroid lineage cell namespace: cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm] is_a: CL:0000764 ! erythroid lineage cell created_by: tmeehan creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast namespace: cell def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698] is_a: CL:0000222 ! mesodermal cell relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell created_by: tmeehan creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell namespace: cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_completed GO:0045058 ! T cell selection intersection_of: has_plasma_membrane_part GO:0042101 ! T cell receptor complex relationship: has_completed GO:0045058 ! T cell selection relationship: has_plasma_membrane_part GO:0042101 ! T cell receptor complex created_by: tmeehan creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell namespace: cell def: "A T cell that has not completed T cell selection." [GOC:tfm] synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: has_not_completed GO:0045058 ! T cell selection created_by: tmeehan creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002421 name: nucleated reticulocyte namespace: cell def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 {is_inferred="true"} ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte namespace: cell def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464] xref: CALOHA:TS-0864 xref: FMA:66785 is_a: CL:0000225 ! anucleate cell is_a: CL:0000558 {is_inferred="true"} ! reticulocyte intersection_of: CL:0000558 ! reticulocyte intersection_of: bearer_of PATO:0001405 ! anucleate intersection_of: has_part GO:0005840 ! ribosome relationship: bearer_of PATO:0001405 ! anucleate relationship: has_part GO:0005840 ! ribosome created_by: tmeehan creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002423 name: DN2a thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-hi." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-low." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: develops_from CL:0002423 ! DN2a thymocyte relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002425 name: early T lineage precursor namespace: cell def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:16551251] comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha created_by: tmeehan creation_date: 2010-10-21T01:16:24Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell namespace: cell def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [GOC:tfm, http://www.immgen.org/index_content.html] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte namespace: cell def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: bearer_of PATO:0000587 ! decreased size relationship: bearer_of PATO:0000587 ! decreased size created_by: tmeehan creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast namespace: cell def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: participates_in GO:0008283 ! cell proliferation relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002427 ! resting double-positive thymocyte relationship: participates_in GO:0008283 ! cell proliferation created_by: tmeehan creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002428 ! double-positive blast relationship: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule created_by: tmeehan creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte namespace: cell def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule created_by: tmeehan creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte namespace: cell def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte namespace: cell def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http:www.immgen.org/index_content.html] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell namespace: cell def: "A mature NK cell that is NK1.1-positive." [GOC:tfm] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C created_by: tmeehan creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is NKGA2-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein relationship: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein created_by: tmeehan creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 relationship: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 created_by: tmeehan creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 created_by: tmeehan creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0002446 ! Ly49CI-negative natural killer cell is_a: CL:0002447 ! CD94-negative natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 relationship: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 created_by: tmeehan creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 relationship: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 created_by: tmeehan creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 created_by: tmeehan creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 relationship: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 created_by: tmeehan creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002441 ! CD94-positive natural killer cell is_a: CL:0002443 ! Ly49CI-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0002450 name: tether cell namespace: cell def: "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." [GOC:cvs, GOC:tfm, PMID:9398434] is_a: CL:0002374 ! ear hair cell created_by: tmeehan creation_date: 2010-11-10T01:41:00Z [Term] id: CL:0002451 name: mammary stem cell namespace: cell def: "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." [GOC:hjd, GOC:tfm, PMID:15987436, PMID:16397499, PMID:17851544] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-11-10T01:46:51Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell namespace: cell def: "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:20142420] is_a: CL:0000123 {is_inferred="true"} ! neuron associated cell (sensu Vertebrata) intersection_of: CL:0000123 ! neuron associated cell (sensu Vertebrata) intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell namespace: cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002455 name: CD8_alpha-negative plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:27:37Z [Term] id: CL:0002456 name: CD8_alpha-positive plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:23:07Z [Term] id: CL:0002457 name: epidermal Langerhans cell namespace: cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: RO:0001025 UBERON:0001003 ! skin epidermis relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: RO:0001025 UBERON:0001003 ! skin epidermis created_by: tmeehan creation_date: 2010-11-22T03:57:57Z [Term] id: CL:0002458 name: langerin-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-11-22T04:06:22Z [Term] id: CL:0002459 name: langerin-negative dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell relationship: lacks_plasma_membrane_part CL:0002507 ! langerin-positive lymph node dendritic cell relationship: lacks_plasma_membrane_part CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-22T04:09:44Z [Term] id: CL:0002460 name: CD8alpha-negative thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-23T10:58:53Z [Term] id: CL:0002461 name: CD103-positive dendritic cell namespace: cell def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-23T01:32:43Z [Term] id: CL:0002462 name: adipose dendritic cell namespace: cell def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell namespace: cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002466 name: small intestine serosal dendritic cell namespace: cell def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.11cloSer.SI" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-23T02:00:21Z [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T02:15:12Z [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T02:19:43Z [Term] id: CL:0002469 name: MHC-II-negative classical monocyte namespace: cell def: "Gr1-high monocyte that lacks MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:27:12Z [Term] id: CL:0002470 name: MHC-II-positive classical monocyte namespace: cell def: "Gr1-high monocyte that has a MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:30:21Z [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:38:15Z [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:47:53Z [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:47:55Z [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002469 {is_inferred="true"} ! MHC-II-negative classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T04:00:52Z [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002469 ! MHC-II-negative classical monocyte is_a: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 created_by: tmeehan creation_date: 2010-11-23T04:09:09Z [Term] id: CL:0002476 name: bone marrow macrophage namespace: cell def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.BM" RELATED [] xref: BTO:0004732 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C2 relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-11-23T04:19:25Z [Term] id: CL:0002477 name: adipose macrophage namespace: cell def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage namespace: cell def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 created_by: tmeehan creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage namespace: cell def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002480 name: nasal mucosa goblet cell namespace: cell def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm] xref: MP:0002262 is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa relationship: part_of UBERON:0001826 ! nasal cavity mucosa relationship: part_of UBERON:0005384 ! nasal cavity epithelium created_by: tmeehan creation_date: 2010-12-03T03:03:02Z [Term] id: CL:0002481 name: peritubular myoid cell namespace: cell def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420] is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis created_by: tmeehan creation_date: 2010-12-03T03:11:48Z [Term] id: CL:0002482 name: dermal melanocyte namespace: cell def: "A melanocyte that produces pigment in the dermis." [GOC:cjm, GOC:tfm, MP:0009386] is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2010-12-03T03:17:05Z [Term] id: CL:0002483 name: hair follicle melanocyte namespace: cell def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381] is_a: CL:0000148 {is_inferred="true"} ! melanocyte is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2010-12-03T03:17:09Z [Term] id: CL:0002484 name: epithelial melanocyte namespace: cell def: "A melanocyte that produces pigment in the epithelium." [GOC:tfm, MP:0009388] comment: The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium. is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000483 ! epithelium relationship: part_of UBERON:0000483 ! epithelium created_by: tmeehan creation_date: 2010-12-03T03:17:14Z [Term] id: CL:0002485 name: retinal melanocyte namespace: cell def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [GOC:tfm, MP:0010190] is_a: CL:0000148 {is_inferred="true"} ! melanocyte is_a: CL:0009004 ! retinal cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2010-12-03T03:25:32Z [Term] id: CL:0002486 name: strial intermediate cell namespace: cell def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048] is_a: CL:0002484 ! epithelial melanocyte is_a: CL:0002491 ! auditory epithelial cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-03T03:29:15Z [Term] id: CL:0002487 name: cutaneous/subcutaneous mechanoreceptor cell namespace: cell def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [GOC:tfm, MP:0000973] is_a: CL:0000199 ! mechanoreceptor cell created_by: tmeehan creation_date: 2010-12-06T02:53:30Z [Term] id: CL:0002488 name: trophoblast giant cell namespace: cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [GOC:tfm, MP:0001714, MP:19876834] synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 {is_inferred="true"} ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: capable_of GO:0001974 ! blood vessel remodeling relationship: bearer_of PATO:0000586 ! increased size relationship: capable_of GO:0001974 ! blood vessel remodeling created_by: tmeehan creation_date: 2010-12-06T02:55:24Z [Term] id: CL:0002489 name: double negative thymocyte namespace: cell def: "A thymocyte that lacks expression of CD4 and CD8." [GOC:tfm, MP:0002407] synonym: "double negative T cell" BROAD [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 created_by: tmeehan creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002490 name: organ of Corti supporting cell namespace: cell def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300] is_a: CL:0002315 ! supporting cell of cochlea intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea relationship: part_of UBERON:0002227 ! spiral organ of cochlea created_by: tmeehan creation_date: 2010-12-06T03:09:01Z [Term] id: CL:0002491 name: auditory epithelial cell namespace: cell def: "A specialized cell involved in auditory sensory perception." [GOC:tfm] is_a: CL:0000098 ! sensory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound created_by: tmeehan creation_date: 2010-12-06T03:18:43Z [Term] id: CL:0002492 name: strial marginal cell namespace: cell def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [GOC:tfm, MP:0004366] is_a: CL:0002491 ! auditory epithelial cell created_by: tmeehan creation_date: 2010-12-06T03:20:41Z [Term] id: CL:0002493 name: strial basal cell namespace: cell def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [GOC:tfm, MP:0004365] comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] is_a: CL:0002491 ! auditory epithelial cell relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-06T03:26:53Z [Term] id: CL:0002494 name: cardiocyte namespace: cell def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0007100 ! primary circulatory organ relationship: part_of UBERON:0007100 ! primary circulatory organ created_by: tmeehan creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002495 name: fetal cardiomyocyte namespace: cell def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [GOC:tfm, MP:0008788] synonym: "embryonic cardiomyocyte" EXACT [] synonym: "neonatal cardiomyocyte" EXACT [] is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-12-07T09:50:41Z [Term] id: CL:0002496 name: intraepithelial lymphocyte namespace: cell def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [GOC:tfm, MP:0008894] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: capable_of GO:0002385 ! mucosal immune response intersection_of: RO:0001025 UBERON:0001277 ! intestinal epithelium relationship: capable_of GO:0002385 ! mucosal immune response relationship: RO:0001025 UBERON:0001277 ! intestinal epithelium created_by: tmeehan creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002497 name: primary trophoblast giant cell namespace: cell def: "A trophoblast giant cell derived from the mural trophectoderm." [GOC:tfm, PMCID:PMC85124] xref: EMAPA:16066 is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:47Z [Term] id: CL:0002498 name: secondary trophoblast giant cell namespace: cell def: "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." [GOC:tfm, PMCID:PMC85124] is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:52Z [Term] id: CL:0002499 name: spongiotrophoblast cell namespace: cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-12-07T12:56:56Z [Term] id: CL:0002500 name: P enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." [FMA:63418, GOC:tfm] is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:06Z [Term] id: CL:0002501 name: type D1 enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." [FMA:63207, GOC:tfm] xref: FMA:63207 is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:09Z [Term] id: CL:0002502 name: type M enteroendocrine cell namespace: cell def: "An enteroendocrine cell of the small intestine that secretes motilin." [GOC:tfm, PMID:15153415] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:63420 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell is_a: CL:1001598 ! small intestine glandular cell relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-12-07T03:55:49Z [Term] id: CL:0002503 name: adventitial cell namespace: cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0005742 ! adventitia relationship: part_of UBERON:0005742 ! adventitia created_by: tmeehan creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell namespace: cell def: "A smooth muscle cell of the intestine." [GOC:tfm] synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002505 name: liver CD103-negative dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [GOC:tfm, http:http\://www.immgen.org/index_content.html] synonym: "DC.103-11b+.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: RO:0001025 UBERON:0001281 ! hepatic sinusoid relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: RO:0001025 UBERON:0001281 ! hepatic sinusoid created_by: tmeehan creation_date: 2011-01-21T01:27:41Z [Term] id: CL:0002506 name: liver CD103-positive dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [GOC:tfm, http:http\://www.immgen.org/index_content.html] synonym: "DC.103+11b-.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: RO:0001025 UBERON:0001281 ! hepatic sinusoid relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: RO:0001025 UBERON:0001281 ! hepatic sinusoid created_by: tmeehan creation_date: 2011-01-21T01:27:45Z [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2011-01-21T01:57:00Z [Term] id: CL:0002508 name: langerin-negative, CD103-negative lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K created_by: tmeehan creation_date: 2011-01-21T02:13:58Z [Term] id: CL:0002509 name: CD103-positive, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2011-01-21T02:07:54Z [Term] id: CL:0002510 name: CD103-negative, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2011-01-21T02:11:14Z [Term] id: CL:0002511 name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2011-01-21T02:22:15Z [Term] id: CL:0002512 name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2011-01-21T02:16:21Z [Term] id: CL:0002513 name: Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "tgd.vg5+.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:22:18Z [Term] id: CL:0002514 name: Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "tgd.vg5-.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:25:44Z [Term] id: CL:0002515 name: interrenal norepinephrine type cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." [GOC:MH, GOC:tfm, PMID:12668625] synonym: "interrenal noradrenaline type cell" EXACT [] synonym: "type n interrenal cell" EXACT [] is_a: CL:0000459 ! noradrenergic cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:11:55Z [Term] id: CL:0002516 name: interrenal chromaffin cell namespace: cell def: "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." [GOC:MH, GOC:tfm, PMID:12668625] is_a: CL:0000166 ! chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:21:35Z [Term] id: CL:0002517 name: interrenal epinephrin secreting cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." [GOC:MH, GOC:tfm, PMID:12668625] synonym: "interrenal adrenaline secreting cell" RELATED [] synonym: "type a interrenal cell" EXACT [] is_a: CL:0000454 ! epinephrine secreting cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:27:05Z [Term] id: CL:0002518 name: kidney epithelial cell namespace: cell def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ] xref: KUPO:0001019 is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney created_by: tmeehan creation_date: 2011-02-08T10:46:34Z [Term] id: CL:0002519 name: interrenal epithelial cell namespace: cell def: "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." [GOC:mh, GOC:tfm, PMID:12668625] is_a: CL:0002518 ! kidney epithelial cell created_by: tmeehan creation_date: 2011-02-08T11:03:32Z [Term] id: CL:0002520 name: nephrocyte namespace: cell def: "An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis." [GOC:tfm, PMID:19783135] xref: BTO:0004597 xref: FMA:83807 is_a: CL:0002522 ! renal filtration cell created_by: tmeehan creation_date: 2011-02-08T01:34:56Z [Term] id: CL:0002521 name: subcutaneous fat cell namespace: cell def: "A fat cell that is part of subcutaneous adipose tissue." [GOC:tfm] synonym: "subcutaneous adipocyte" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue created_by: tmeehan creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002522 name: renal filtration cell namespace: cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm] is_a: CL:0000424 ! excretory cell relationship: part_of UBERON:0001008 ! renal system created_by: tmeehan creation_date: 2011-02-08T01:37:59Z [Term] id: CL:0002523 name: mesonephric glomerular visceral epithelial cell namespace: cell def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros" [GOC:tfm] is_a: CL:0000653 ! glomerular visceral epithelial cell intersection_of: CL:0000653 ! glomerular visceral epithelial cell intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros created_by: tmeehan creation_date: 2011-02-08T01:58:30Z [Term] id: CL:0002524 name: disseminated nephrocyte namespace: cell def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [GOC:tfm, PMID:19783135] is_a: CL:0002520 ! nephrocyte created_by: tmeehan creation_date: 2011-02-08T02:07:33Z [Term] id: CL:0002525 name: metanephric glomerular visceral epithelial cell namespace: cell def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:tfm] is_a: CL:0000653 ! glomerular visceral epithelial cell intersection_of: CL:0000653 ! glomerular visceral epithelial cell intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros created_by: tmeehan creation_date: 2011-02-08T02:02:13Z [Term] id: CL:0002526 name: CD14-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [GOC:dsd, PMID:19236899, PMID:20309010] comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. synonym: "CD14+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: capable_of GO:0045191 ! regulation of isotype switching intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: capable_of GO:0045191 ! regulation of isotype switching relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0002527 name: immature CD14-positive dermal dendritic cell namespace: cell def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002528 name: mature CD14-positive dermal dendritic cell namespace: cell def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GOC:dsd] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002527 ! immature CD14-positive dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002529 name: CD1a-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [GOC:dsd, PMID:20309010] comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. synonym: "CD1a+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0002530 name: immature CD1a-positive dermal dendritic cell namespace: cell def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002531 name: mature CD1a-positive dermal dendritic cell namespace: cell def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002530 ! immature CD1a-positive dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [GOC:dsd, PMID:17332250] comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: capable_of GO:0032640 ! tumor necrosis factor production intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: capable_of GO:0032640 ! tumor necrosis factor production relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell namespace: cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell namespace: cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002533 ! immature CD16-positive myeloid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002535 name: epithelial cell of cervix namespace: cell def: "An epithelial cell of the cervix." [GOC:tfm] synonym: "cervical canal epithelial cell" EXACT [GOC:tfm] synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm] synonym: "cervix epithelial cell" EXACT [GOC:tfm] synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm] synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm] synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium created_by: tmeehan creation_date: 2011-02-24T08:20:08Z [Term] id: CL:0002536 name: epithelial cell of amnion namespace: cell def: "An epithelial cell that is part of the amnion." [GOC:tfm] synonym: "amniotic epithelial cell" EXACT [] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:38:01Z [Term] id: CL:0002537 name: amnion mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039] synonym: "amniotic membrane stem cell" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:44:24Z [Term] id: CL:0002538 name: intrahepatic bile duct epithelial cell namespace: cell def: "An epithelial cell of the intrahepatic portion of the bile duct." [GOC:tfm] is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium created_by: tmeehan creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell namespace: cell def: "A smooth muscle cell of the aorta." [GOC:tfm] xref: BTO:0004577 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue created_by: tmeehan creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow namespace: cell def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002541 name: chorionic membrane mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0003124 ! chorion relationship: part_of UBERON:0003124 ! chorion created_by: tmeehan creation_date: 2011-02-28T03:04:35Z [Term] id: CL:0002543 name: vein endothelial cell namespace: cell alt_id: CL:1000393 def: "An endothelial cell that is part of the vein." [GOC:tfm] synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein created_by: tmeehan creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002544 name: aortic endothelial cell namespace: cell def: "An arterial endothelial cell that is part of the aorta endothelium." [GOC:tfm] xref: BTO:0003245 xref: CALOHA:TS-0047 is_a: CL:1000413 ! endothelial cell of artery created_by: tmeehan creation_date: 2011-02-28T03:54:42Z [Term] id: CL:0002545 name: thoracic aorta endothelial cell namespace: cell def: "An endothelial cell that is part of the thoracic endothelium." [GOC:tfm] is_a: CL:0002544 {is_inferred="true"} ! aortic endothelial cell intersection_of: CL:0002544 ! aortic endothelial cell intersection_of: part_of UBERON:0001515 ! thoracic aorta relationship: part_of UBERON:0001515 ! thoracic aorta created_by: tmeehan creation_date: 2011-02-28T03:59:09Z [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell namespace: cell def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] comment: See CL:0002619. is_a: CL:0000222 ! mesodermal cell is_a: CL:0002371 ! somatic cell created_by: tmeehan creation_date: 2011-02-28T04:20:39Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia namespace: cell def: "A fibroblast of the aortic adventitia." [GOC:tfm] is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia relationship: part_of UBERON:0004664 ! aorta tunica adventitia created_by: tmeehan creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: fibroblast of cardiac tissue namespace: cell def: "A fibroblast that is part of the heart." [GOC:tfm] synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002494 {is_inferred="true"} ! cardiocyte intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart created_by: tmeehan creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002549 name: fibroblast of choroid plexus namespace: cell def: "A fibroblast that is part of the choroid plexus." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus created_by: tmeehan creation_date: 2011-02-28T05:01:39Z [Term] id: CL:0002550 name: fibroblast of the conjunctiva namespace: cell def: "A fibroblast that is part of the conjuctiva of the eye." [GOC:tfm] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva created_by: tmeehan creation_date: 2011-02-28T05:03:44Z [Term] id: CL:0002551 name: fibroblast of dermis namespace: cell is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002552 name: fibroblast of gingiva namespace: cell is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001828 ! gingiva relationship: part_of UBERON:0001828 ! gingiva created_by: tmeehan creation_date: 2011-02-28T05:09:12Z [Term] id: CL:0002553 name: fibroblast of lung namespace: cell def: "A fibroblast that is part of lung." [GOC:tfm] xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung created_by: tmeehan creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002554 name: fibroblast of lymphatic vessel namespace: cell def: "A fibroblast of the lymphatic system." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2011-02-28T05:16:18Z [Term] id: CL:0002555 name: fibroblast of mammary gland namespace: cell def: "A fibroblast that is part of the mammary gland." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2011-02-28T05:18:38Z [Term] id: CL:0002556 name: fibroblast of periodontium namespace: cell def: "A fibroblast of the periodontium." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001758 ! periodontium relationship: part_of UBERON:0001758 ! periodontium created_by: tmeehan creation_date: 2011-02-28T05:19:48Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery namespace: cell def: "A fibroblast of pulmonary artery." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002558 name: fibroblast of villous mesenchyme namespace: cell def: "A fibroblast that is part of villous mesenchyme." [GOC:tfm] is_a: CL:0000057 ! fibroblast is_a: CL:0000349 ! extraembryonic cell relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2011-02-28T05:24:28Z [Term] id: CL:0002559 name: hair follicle cell namespace: cell def: "An animal cell that is part of a hair follicle." [GOC:tfm] is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2011-03-01T04:11:01Z [Term] id: CL:0002560 name: inner root sheath cell namespace: cell def: "An epithelial cell that resides in the inner root sheath of the hair follicle." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell intersection_of: CL:0002559 ! hair follicle cell intersection_of: part_of UBERON:0005941 ! hair inner root sheath relationship: part_of UBERON:0005941 ! hair inner root sheath created_by: tmeehan creation_date: 2011-03-01T04:27:51Z [Term] id: CL:0002561 name: outer root sheath cell namespace: cell def: "An epithelial cell that is part of the outer root sheath." [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005942 ! hair outer root sheath relationship: part_of UBERON:0005942 ! hair outer root sheath created_by: tmeehan creation_date: 2011-03-01T04:29:47Z [Term] id: CL:0002562 name: hair germinal matrix cell namespace: cell def: "An epidermal cell that is part of the germinal matrix." [GOC:tfm] synonym: "trichocyte" EXACT [] is_a: CL:0000362 {is_inferred="true"} ! epidermal cell intersection_of: CL:0000362 ! epidermal cell intersection_of: part_of UBERON:0006004 ! hair follicle matrix region relationship: part_of UBERON:0006004 ! hair follicle matrix region created_by: tmeehan creation_date: 2011-03-01T04:31:06Z [Term] id: CL:0002563 name: intestinal epithelial cell namespace: cell def: "An epithelial cell of the intestine." [GOC:tfm] is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001277 ! intestinal epithelium created_by: tmeehan creation_date: 2011-03-01T05:18:31Z [Term] id: CL:0002564 name: nucleus pulposus cell of intervertebral disc namespace: cell def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [GOC:tfm] is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002242 ! nucleus pulposus relationship: part_of UBERON:0002242 ! nucleus pulposus created_by: tmeehan creation_date: 2011-03-02T02:12:23Z [Term] id: CL:0002565 name: iris pigment epithelial cell namespace: cell def: "A pigment cell located in the epithelium of the iris." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: part_of UBERON:0002506 ! iris epithelium relationship: part_of UBERON:0002506 ! iris epithelium created_by: tmeehan creation_date: 2011-03-01T05:28:52Z [Term] id: CL:0002566 name: dark melanocyte namespace: cell def: "A melanocyte that appears darker due to content or amount of melanin granules." [GOC:tfm] is_a: CL:0000148 ! melanocyte created_by: tmeehan creation_date: 2011-03-01T05:57:11Z [Term] id: CL:0002567 name: light melanocyte namespace: cell def: "A melanocyte that appears lighter in color." [GOC:tfm] is_a: CL:0000148 ! melanocyte created_by: tmeehan creation_date: 2011-03-01T05:58:23Z [Term] id: CL:0002568 name: mesenchymal stem cell of Wharton's jelly namespace: cell def: "A mesenchymal stem cell that is part of Wharton's jelly." [GOC:tfm] is_a: CL:0002569 ! mesenchymal stem cell of umbilical cord created_by: tmeehan creation_date: 2011-03-01T09:51:18Z [Term] id: CL:0002569 name: mesenchymal stem cell of umbilical cord namespace: cell def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord created_by: tmeehan creation_date: 2011-03-01T09:55:12Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose namespace: cell def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002571 name: hepatic mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of liver." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2011-03-01T09:58:51Z [Term] id: CL:0002572 name: vertebral mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0001035 ! bone cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002412 ! vertebra relationship: part_of UBERON:0002412 ! vertebra created_by: tmeehan creation_date: 2011-03-01T10:40:27Z [Term] id: CL:0002573 name: Schwann cell namespace: cell def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm] xref: BTO:0001220 xref: CALOHA:TS-0898 is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata) intersection_of: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000010 ! peripheral nervous system created_by: tmeehan creation_date: 2011-03-02T01:19:27Z [Term] id: CL:0002574 name: stromal cell of pancreas namespace: cell def: "A stromal cell of the pancreas." [GOC:tfm] is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2011-03-02T02:40:41Z [Term] id: CL:0002575 name: central nervous system pericyte namespace: cell def: "A pericyte of the central nervous system." [GOC:tfm] is_a: CL:0000669 {is_inferred="true"} ! pericyte cell intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2011-03-02T02:54:18Z [Term] id: CL:0002576 name: perineural cell namespace: cell def: "A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement." [GO:tfm, http://en.wikipedia.org/wiki/Perineurium] is_a: CL:0000186 {is_inferred="true"} ! myofibroblast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000186 ! myofibroblast cell intersection_of: part_of UBERON:0000121 ! perineurium relationship: part_of UBERON:0000121 ! perineurium created_by: tmeehan creation_date: 2011-03-02T03:03:58Z [Term] id: CL:0002577 name: placental epithelial cell namespace: cell def: "An epithelial cell of the placenta." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: tmeehan creation_date: 2011-03-02T03:21:30Z [Term] id: CL:0002578 name: mesenteric preadipocyte namespace: cell def: "A preadipocyte found in mesenteric tissue." [GOC:tfm] is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0002095 ! mesentery relationship: part_of UBERON:0002095 ! mesentery created_by: tmeehan creation_date: 2011-03-03T04:19:40Z [Term] id: CL:0002579 name: omentum preadipocyte namespace: cell is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum created_by: tmeehan creation_date: 2011-03-03T04:19:42Z [Term] id: CL:0002580 name: preadipocyte of the breast namespace: cell def: "A preadipocyte that is part of the breast." [GOC:tfm] is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: tmeehan creation_date: 2011-03-03T04:19:46Z [Term] id: CL:0002581 name: perirenal preadipocyte namespace: cell is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0005406 ! perirenal fat relationship: part_of UBERON:0005406 ! perirenal fat created_by: tmeehan creation_date: 2011-03-03T04:20:04Z [Term] id: CL:0002582 name: visceral preadipocyte namespace: cell def: "A preadipocyte that is part of visceral tissue." [GOC:tfm] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2011-03-03T04:32:56Z [Term] id: CL:0002583 name: subcutaneous preadipocyte namespace: cell def: "A preadipocyte that is part of subcutaneous tissue." [GOC:tfm] is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: part_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis created_by: tmeehan creation_date: 2011-03-03T04:33:01Z [Term] id: CL:0002584 name: renal cortical epithelial cell namespace: cell def: "An epithelial cell of the kidney cortex." [GOC:tfm] xref: KUPO:0001016 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney [Term] id: CL:0002585 name: retinal blood vessel endothelial cell namespace: cell def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002586 name: retinal pigment epithelial cell namespace: cell def: "An epithelial cell of the retinal pigmented epithelium." [GOC:tfm] xref: BTO:0004910 xref: FMA:75802 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000149 ! visual pigment cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001782 ! pigmented layer of retina relationship: has_part GO:0042470 ! melanosome relationship: part_of UBERON:0001782 ! pigmented layer of retina created_by: tmeehan creation_date: 2011-03-06T03:37:09Z [Term] id: CL:0002588 name: smooth muscle cell of the umbilical vein namespace: cell def: "A smooth muscle cell of the umbilical vein." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein created_by: tmeehan creation_date: 2011-03-06T05:00:51Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature namespace: cell def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001529 ! brachiocephalic artery relationship: part_of UBERON:0001529 ! brachiocephalic artery created_by: tmeehan creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature namespace: cell def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell created_by: tmeehan creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery namespace: cell def: "A smooth muscle of the pulmonary artery." [GOC:tfm] xref: BTO:0003336 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002592 name: smooth muscle cell of the coronary artery namespace: cell def: "A smooth muscle cell of the coronary artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001621 ! coronary artery relationship: part_of UBERON:0001621 ! coronary artery created_by: tmeehan creation_date: 2011-03-06T05:01:34Z [Term] id: CL:0002593 name: smooth muscle cell of the internal thoracic artery namespace: cell def: "A smooth muscle of the internal thoracic artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002456 ! internal thoracic artery relationship: part_of UBERON:0002456 ! internal thoracic artery created_by: tmeehan creation_date: 2011-03-06T05:01:41Z [Term] id: CL:0002594 name: smooth muscle cell of the umbilical artery namespace: cell def: "A smooth muscle cell of the umbilical artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001310 ! umbilical artery relationship: part_of UBERON:0001310 ! umbilical artery created_by: tmeehan creation_date: 2011-03-06T05:01:48Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery namespace: cell def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001533 ! subclavian artery relationship: part_of UBERON:0001533 ! subclavian artery created_by: tmeehan creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery namespace: cell def: "Smooth muscle cell of the carotid artery." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0005396 ! carotid artery segment relationship: part_of UBERON:0005396 ! carotid artery segment created_by: tmeehan creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002597 name: smooth muscle cell of bladder namespace: cell def: "A smooth muscle cell of the bladder." [GC:tfm] xref: KUPO:0001122 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder created_by: tmeehan creation_date: 2011-03-06T05:43:24Z [Term] id: CL:0002598 name: bronchial smooth muscle cell namespace: cell xref: BTO:0004402 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2011-03-06T05:46:39Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus namespace: cell def: "A smooth muscle cell of the esophagus." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002600 name: smooth muscle cell of trachea namespace: cell def: "A smooth muscle cell of the trachea." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea created_by: tmeehan creation_date: 2011-03-06T05:50:28Z [Term] id: CL:0002601 name: uterine smooth muscle cell namespace: cell def: "A smooth muscle cell of the uterus." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2011-03-06T05:53:28Z [Term] id: CL:0002602 name: annulus pulposus cell namespace: cell synonym: "anulus pulposus cell" EXACT [] is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis relationship: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis created_by: tmeehan creation_date: 2011-03-06T06:50:53Z [Term] id: CL:0002603 name: astrocyte of the cerebellum namespace: cell def: "An astrocyte of the cerebellum." [GOC:tfm] is_a: CL:0000127 {is_inferred="true"} ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum created_by: tmeehan creation_date: 2011-03-06T06:57:27Z [Term] id: CL:0002604 name: astrocyte of the hippocampus namespace: cell is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:1001580 ! hippocampus glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T06:57:33Z [Term] id: CL:0002605 name: astrocyte of the cerebral cortex namespace: cell def: "An astrocyte of the cerebral cortex." [GOC:tfm] is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex created_by: tmeehan creation_date: 2011-03-06T06:57:36Z [Term] id: CL:0002606 name: astrocyte of the spinal cord namespace: cell def: "An astrocyte of the spinal cord." [GOC:tfm] is_a: CL:0000127 {is_inferred="true"} ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord created_by: tmeehan creation_date: 2011-03-06T07:11:26Z [Term] id: CL:0002607 name: migratory enteric neural crest cell namespace: cell def: "A neural crest cell that gives rise to cells of the enteric nervous system." [GOC:tfm] is_a: CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-03-06T07:24:35Z [Term] id: CL:0002608 name: hippocampal neuron namespace: cell def: "A neuron of the hippocampus." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T07:31:49Z [Term] id: CL:0002609 name: neuron of cerebral cortex namespace: cell def: "A CNS neuron of the cerebral cortex." [GOC:tfm] synonym: "cortical neuron" EXACT [] xref: BTO:0004102 xref: FMA:84104 is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex created_by: tmeehan creation_date: 2011-03-06T07:37:08Z [Term] id: CL:0002610 name: raphe nuclei neuron namespace: cell def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0004684 ! raphe nuclei relationship: part_of UBERON:0004684 ! raphe nuclei created_by: tmeehan creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002611 name: neuron of the dorsal spinal cord namespace: cell def: "A CNS neuron of the dorsal spinal cord." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord created_by: tmeehan creation_date: 2011-03-06T07:43:34Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord namespace: cell def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002257 ! ventral horn of spinal cord relationship: part_of UBERON:0002257 ! ventral horn of spinal cord created_by: tmeehan creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002613 name: striatum neuron namespace: cell def: "A neuron of the striatum." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002435 ! striatum relationship: part_of UBERON:0002435 ! striatum created_by: tmeehan creation_date: 2011-03-06T07:47:12Z [Term] id: CL:0002614 name: neuron of the substantia nigra namespace: cell def: "A neuron of the substantia nigra." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0002038 ! substantia nigra relationship: part_of UBERON:0002038 ! substantia nigra created_by: tmeehan creation_date: 2011-03-06T07:48:42Z [Term] id: CL:0002615 name: adipocyte of omentum tissue namespace: cell def: "A fat cell that is part of omentum tissue." [GOC:tfm] synonym: "omental adipocyte" EXACT [] synonym: "omental fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum created_by: tmeehan creation_date: 2011-03-14T10:17:00Z [Term] id: CL:0002616 name: perirenal adipocyte cell namespace: cell def: "A fat cell of perirenal fat tissue." [GOC:tfm] synonym: "perirenal fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0005406 ! perirenal fat relationship: part_of UBERON:0005406 ! perirenal fat created_by: tmeehan creation_date: 2011-03-14T10:17:05Z [Term] id: CL:0002617 name: adipocyte of breast namespace: cell def: "A fat cell that is part of the breast." [GOC:tfm] comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA] synonym: "breast adipocyte" EXACT [] synonym: "fat cell of breast" EXACT [] xref: CALOHA:TS-2377 is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: tmeehan creation_date: 2011-03-14T10:17:07Z [Term] id: CL:0002618 name: endothelial cell of umbilical vein namespace: cell def: "An endothelial cell of the umbilical vein." [GOC:tfm] xref: BTO:0004296 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002066 ! umbilical vein relationship: part_of UBERON:0002066 ! umbilical vein created_by: tmeehan creation_date: 2011-03-14T11:36:51Z [Term] id: CL:0002619 name: adult endothelial progenitor cell namespace: cell def: "An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial." [GOC:tfm, PMID:20807818, PMID:9020076] synonym: "EPC" EXACT [] is_a: CL:0000566 ! angioblastic mesenchymal cell created_by: tmeehan creation_date: 2011-03-14T12:11:18Z [Term] id: CL:0002620 name: skin fibroblast namespace: cell def: "A fibroblast of skin." [GOC:tfm] xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002621 name: gingival epithelial cell namespace: cell is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001949 ! gingival epithelium relationship: part_of UBERON:0001949 ! gingival epithelium created_by: tmeehan creation_date: 2011-03-14T12:46:28Z [Term] id: CL:0002622 name: prostate stromal cell namespace: cell def: "A stromal cell of the prostate." [GOC:tfm] xref: BTO:0003972 is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2011-03-14T02:11:10Z [Term] id: CL:0002623 name: acinar cell of salivary gland namespace: cell def: "An acinar cell of salivary gland." [GOC:tfm] is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001596 ! salivary gland glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001044 ! saliva-secreting gland relationship: part_of UBERON:0001044 ! saliva-secreting gland created_by: tmeehan creation_date: 2011-03-14T02:22:22Z [Term] id: CL:0002624 name: paneth cell of the appendix namespace: cell def: "A paneth cell of the appendix." [GOC:tfm] is_a: CL:0000510 {is_inferred="true"} ! paneth cell is_a: CL:1001585 ! appendix glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix created_by: tmeehan creation_date: 2011-03-15T09:38:18Z [Term] id: CL:0002625 name: seminiferous tubule epithelial cell namespace: cell def: "A cell of the seminiferous tubule epithelium." [GOC:tfm] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium created_by: tmeehan creation_date: 2011-03-15T11:59:23Z [Term] id: CL:0002626 name: immature astrocyte namespace: cell def: "An immature astrocyte." [GOC:dsd] synonym: "immature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002627 name: mature astrocyte namespace: cell def: "A mature astrocyte that is capable of producing cytokines." [GOC:dsd, PMID:12898703, PMID:8734446] comment: Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta. synonym: "activated astrocyte" EXACT [] synonym: "mature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002628 name: immature microglial cell namespace: cell def: "An immature microglial cell with a ramified morphology." [GOC:dsd, PMID:18396103, PMID:19461673] comment: Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative. synonym: "immature microglia" EXACT [] synonym: "quiescent microglia" EXACT [PMID:18396103] synonym: "resting microglia" EXACT [PMID:18396103] is_a: CL:0000129 ! microglial cell [Term] id: CL:0002629 name: mature microglial cell namespace: cell def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [GOC:dsd, PMID:11517395, PMID:14612429, PMID:15246020, PMID:16177057, PMID:18396103, PMID:20021364] comment: Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha. synonym: "activated microglia" EXACT [PMID:18396103] synonym: "mature microglia" EXACT [] synonym: "reactive microglia" EXACT [PMID:18396103] is_a: CL:0000129 {is_inferred="true"} ! microglial cell intersection_of: CL:0000129 ! microglial cell intersection_of: capable_of GO:0001816 ! cytokine production intersection_of: capable_of GO:0002536 ! respiratory burst involved in inflammatory response intersection_of: capable_of GO:0002537 ! nitric oxide production involved in inflammatory response intersection_of: capable_of GO:0006909 ! phagocytosis intersection_of: capable_of GO:0019882 ! antigen processing and presentation relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0002536 ! respiratory burst involved in inflammatory response relationship: capable_of GO:0002537 ! nitric oxide production involved in inflammatory response relationship: capable_of GO:0006909 ! phagocytosis relationship: capable_of GO:0019882 ! antigen processing and presentation [Term] id: CL:0002630 name: actinomycete-type spore namespace: cell def: "A spore formed from bacteria in the order Actinomycetales." [GO:0034304, GOC:tfm] is_a: CL:0000520 ! prokaryotic cell created_by: tmeehan creation_date: 2011-06-16T01:01:41Z [Term] id: CL:0002631 name: epithelial cell of upper respiratory tract namespace: cell is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: part_of UBERON:0001557 ! upper respiratory tract relationship: part_of UBERON:0001557 ! upper respiratory tract created_by: tmeehan creation_date: 2011-06-21T12:28:55Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract namespace: cell is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract created_by: tmeehan creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002633 name: respiratory basal cell namespace: cell def: "A basal cell in the respiratory tract." [GOC:tfm, PMID:20699479] synonym: "airway basal cell" EXACT [] synonym: "airway basal stem cell" EXACT [] is_a: CL:0000646 ! basal cell is_a: CL:0002368 ! respiratory epithelial cell created_by: tmeehan creation_date: 2011-06-21T03:11:10Z [Term] id: CL:0002634 name: epithelial cell of anal column namespace: cell def: "An epithelial cell of the anal column." [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0009882 ! anal column relationship: part_of UBERON:0009882 ! anal column created_by: tmeehan creation_date: 2011-07-08T12:11:38Z [Term] id: CL:0002635 name: nonkeratinized epithelial cell of anal column namespace: cell def: "A nonkeratinized epithelial cell of the anal canal." [GOC:tfm] xref: FMA:263146 is_a: CL:0002634 ! epithelial cell of anal column created_by: tmeehan creation_date: 2011-07-08T02:05:33Z [Term] id: CL:0002636 name: nonkeratinized epithelial cell of inferior part of anal canal namespace: cell def: "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." [GOC:tfm] xref: FMA:263144 is_a: CL:0002635 ! nonkeratinized epithelial cell of anal column is_a: CL:1000438 ! epithelial cell of wall of inferior part of anal canal created_by: tmeehan creation_date: 2011-07-08T02:06:53Z [Term] id: CL:0002637 name: keratinized epithelial cell of the anal canal namespace: cell def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [GOC:tfm] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002634 ! epithelial cell of anal column intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal created_by: tmeehan creation_date: 2011-07-08T02:08:40Z [Term] id: CL:0002638 name: bronchioalveolar stem cell namespace: cell def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and Clara cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." [GOC:tfm, PMID:15960971] synonym: "basal epithelial cell of bronchioalveolar duct junction" EXACT [] synonym: "BASC" EXACT [] is_a: CL:1000350 ! basal cell of epithelium of terminal bronchiole is_a: CL:1000351 ! basal cell of epithelium of respiratory bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium created_by: tmeehan creation_date: 2011-06-21T03:26:08Z [Term] id: CL:0002639 name: amniotic stem cell namespace: cell def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" [GOC:tfm, PMID:20942606] comment: Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now. is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002323 ! amniocyte created_by: tmeehan creation_date: 2011-06-21T03:55:39Z [Term] id: CL:0002640 name: amniotic epithelial stem cell namespace: cell def: "An epithelial fate stem cell derived form the amnion membrane." [GOC:tfm, PMID:20446274] is_a: CL:0000036 ! epithelial fate stem cell created_by: tmeehan creation_date: 2011-06-21T04:06:17Z [Term] id: CL:0002641 name: epithelial cell of esophageal gland proper namespace: cell def: "An epithelial cell of the esophageal gland proper." [GOC:tfm] xref: FMA:256141 is_a: CL:0002657 ! glandular cell of esophagus created_by: tmeehan creation_date: 2011-07-08T02:16:51Z [Term] id: CL:0002642 name: epithelial cell of esophageal cardiac gland namespace: cell def: "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." [GOC:tfm, http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html] xref: FMA:256143 is_a: CL:0002657 ! glandular cell of esophagus created_by: tmeehan creation_date: 2011-07-08T02:16:54Z [Term] id: CL:0002643 name: nonkeratinized cell of stratum corneum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." [GOC:tfm] xref: FMA:263148 is_a: CL:0002654 ! epithelial cell of stratum corneum of esophageal epithelium created_by: tmeehan creation_date: 2011-07-08T02:22:09Z [Term] id: CL:0002644 name: endo-epithelial cell of tympanic part of viscerocranial mucosa namespace: cell def: "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70628 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:25:44Z [Term] id: CL:0002645 name: endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa namespace: cell def: "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." [GOC:tfm] xref: FMA:70629 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2011-07-08T02:25:46Z [Term] id: CL:0002646 name: obsolete epithelial cell of buccal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70577 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:34:12Z [Term] id: CL:0002647 name: obsolete epithelial cell of anterior palatal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70580 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:34:14Z [Term] id: CL:0002648 name: obsolete epithelial cell of nasal part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70554 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:36:06Z [Term] id: CL:0002649 name: obsolete epithelial cell of gingival part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70579 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:36:11Z [Term] id: CL:0002650 name: obsolete epithelial cell of paranasal sinus part of viscerocranial mucosa namespace: cell def: "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70578 is_obsolete: true created_by: tmeehan creation_date: 2011-07-08T02:38:18Z [Term] id: CL:0002651 name: endothelial cell of venous sinus of spleen namespace: cell def: "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." [GOC:tfm] synonym: "stave cell" EXACT [FMA:62817] xref: FMA:72140 is_a: CL:0002262 ! endothelial cell of sinusoid created_by: tmeehan creation_date: 2011-07-08T03:06:49Z [Term] id: CL:0002652 name: endothelial cell of high endothelial venule namespace: cell def: "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [GOC:tfm, PMID:20726857] comment: Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG. synonym: "endothelial cell of postcapillary venule of lymph node" EXACT [] synonym: "HEV cell" EXACT [] xref: FMA:67759 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:1000414 ! endothelial cell of venule created_by: tmeehan creation_date: 2011-07-08T03:14:10Z [Term] id: CL:0002653 name: squamous endothelial cell namespace: cell def: "A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." [GOC:tfm] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:1000414 ! endothelial cell of venule created_by: tmeehan creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002654 name: epithelial cell of stratum corneum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum corneum of esophageal epithelium." [GOC:tfm] xref: FMA:70733 is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2011-07-08T03:46:35Z [Term] id: CL:0002655 name: epithelial cell of stratum spinosum of esophageal epithelium namespace: cell def: "An epithelial cell of stratum spinosum of esophageal epithelium." [GOC:tfm] xref: FMA:70732 is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2011-07-08T03:48:26Z [Term] id: CL:0002656 name: glandular cell of endometrium namespace: cell def: "A glandular epithelial cell of the endometrium." [GOC:tfm] xref: FMA:86489 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2011-07-08T03:54:08Z [Term] id: CL:0002657 name: glandular cell of esophagus namespace: cell def: "A glandular epithelial cell of the esophagus." [GOC:tfm] xref: FMA:86548 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002658 name: glandular cell of the large intestine namespace: cell def: "A glandular epithelial cell of the large intestine." [GOC:tfm] xref: FMA:87194 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2011-07-08T04:03:01Z [Term] id: CL:0002659 name: glandular cell of stomach namespace: cell def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] xref: CALOHA:TS-1284 xref: FMA:86554 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002660 name: luminal cell of acinus of lactiferous gland namespace: cell def: "A luminal epithelial cell of mammary gland located in acinus of structure." [GOC:tfm] comment: Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type. xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland created_by: tmeehan creation_date: 2011-07-11T01:44:31Z [Term] id: CL:0002661 name: luminal cell of lactiferous terminal ductal lobular unit namespace: cell def: "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." [GOC:tfm] xref: FMA:87168 is_a: CL:0002662 ! luminal cell of lactiferous duct created_by: tmeehan creation_date: 2011-07-11T01:44:33Z [Term] id: CL:0002662 name: luminal cell of lactiferous duct namespace: cell def: "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." [GOC:tfm, PMID:19022771] xref: FMA:74504 xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland created_by: tmeehan creation_date: 2011-07-11T01:44:48Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium namespace: cell def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] xref: FMA:83389 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium created_by: tmeehan creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast namespace: cell def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002665 name: otic fibrocyte namespace: cell def: "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." [GOC:tfm, PMID:18353863] is_a: CL:0000135 ! fibrocyte relationship: part_of UBERON:0006725 ! spiral ligament created_by: tmeehan creation_date: 2011-07-11T03:35:01Z [Term] id: CL:0002666 name: type 2 otic fibrocyte namespace: cell def: "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type II otic fibrocyte" EXACT [] synonym: "type II spiral ligament fibrocyte" EXACT [MP:0004488] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:40Z [Term] id: CL:0002667 name: type 5 otic fibrocyte namespace: cell def: "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type V otic fibrocyte" EXACT [] synonym: "type V spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:42Z [Term] id: CL:0002668 name: type 4 otic fibrocyte namespace: cell def: "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." [GOC:tfm, PMID:18353863] synonym: "type IV otic fibrocyte" EXACT [] synonym: "type IV spiral ligament fibrocyte" EXACT [MP:0004490] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:46Z [Term] id: CL:0002669 name: type 3 otic fibrocyte namespace: cell def: "An otic fibrocyte that lines the otic capsule." [GOC:tfm, PMID:18353863] synonym: "type III otic fibrocyte" EXACT [] synonym: "type III spiral ligament fibrocyte" EXACT [MP:0004489] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:40:50Z [Term] id: CL:0002670 name: type 1 otic fibrocyte namespace: cell def: "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type I otic fibrocyte" EXACT [] synonym: "type I spiral ligament fibrocyte" EXACT [MP:0004487] is_a: CL:0002665 ! otic fibrocyte created_by: tmeehan creation_date: 2011-07-11T03:39:27Z [Term] id: CL:0002671 name: endothelial stalk cell namespace: cell def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." [GOC:tfm, PMID:21521739] is_a: CL:0000071 ! blood vessel endothelial cell created_by: tmeehan creation_date: 2011-08-16T01:49:32Z [Term] id: CL:0002672 name: retinal progenitor cell namespace: cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000133 ! neurectodermal cell created_by: tmeehan creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002673 name: tongue muscle cell namespace: cell def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: part_of UBERON:0000378 ! tongue muscle relationship: part_of UBERON:0000378 ! tongue muscle created_by: tmeehan creation_date: 2011-08-16T03:10:02Z [Term] id: CL:0002674 name: H minus namespace: cell def: "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." [GOC:tfm] synonym: "H- cell" EXACT [] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2011-08-16T03:20:53Z [Term] id: CL:0002675 name: H plus namespace: cell def: "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." [GOC:tfm] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2011-08-16T03:20:58Z [Term] id: CL:0002676 name: neural crest derived neuroblast namespace: cell def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0002677 name: naive regulatory T cell namespace: cell def: "A regulatory T cell that has not encountered antigen." [GOC:tfm] comment: This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell. synonym: "naive regulatory T lymphocyte" EXACT [] synonym: "naive regulatory T-cell" EXACT [] synonym: "naive regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000898 ! naive T cell created_by: tmeehan creation_date: 2011-08-25T03:17:21Z [Term] id: CL:0002678 name: memory regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [GOC:tfm, PMID:21739668] comment: Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell. is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000813 ! memory T cell created_by: tmeehan creation_date: 2011-08-25T03:17:34Z [Term] id: CL:0002679 name: natural helper lymphocyte namespace: cell def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [GOC:tfm, PMID:20023630] is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2011-08-29T10:08:02Z [Term] id: CL:0002680 name: PP cell of intestine namespace: cell def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] is_a: CL:0000696 {is_inferred="true"} ! PP cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-09-27T11:59:01Z [Term] id: CL:0002681 name: kidney cortical cell namespace: cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 ! cortex of kidney created_by: terryh creation_date: 2011-10-25T03:49:41Z [Term] id: CL:0005000 name: spinal cord interneuron namespace: cell def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 {is_inferred="true"} ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:0005001 name: iridoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS] comment: Derived from UBERON:0002342 neural crest. is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005002 name: xanthoblast namespace: cell def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005003 name: leucoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005004 name: pigment erythroblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005005 name: cyanoblast namespace: cell def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [CL:CVS] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0005006 name: ionocyte namespace: cell def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0005007 name: Kolmer-Agduhr neuron namespace: cell def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739] synonym: "KA cell" EXACT [] synonym: "KA interneuron" EXACT [PMID:15539490] synonym: "KA neuron" EXACT [PMID:9634146] synonym: "Kolmer-Agduhr cell" EXACT [] is_a: CL:0005000 ! spinal cord interneuron is_a: CL:0011005 ! GABAergic interneuron [Term] id: CL:0005008 name: macular hair cell namespace: cell def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [GO:cvs] is_a: CL:0000202 ! auditory hair cell intersection_of: CL:0000202 ! auditory hair cell intersection_of: part_of UBERON:0000054 ! macula relationship: part_of UBERON:0000054 ! macula [Term] id: CL:0005009 name: renal principal cell namespace: cell def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts." [CL:CVS] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002518 ! kidney epithelial cell [Term] id: CL:0005010 name: renal intercalated cell namespace: cell def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS] synonym: "intercalated cell" EXACT [] xref: FMA:86560 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:0002518 ! kidney epithelial cell [Term] id: CL:0005011 name: renal alpha-intercalated cell namespace: cell def: "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." [CL:CVS] is_a: CL:0005010 ! renal intercalated cell [Term] id: CL:0005012 name: multi-ciliated epithelial cell namespace: cell def: "A ciliated epithelial cell with many cilium." [CL:CVS] is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0005013 name: single ciliated epithelial cell namespace: cell def: "A ciliated epithelial cell with a single cilium." [CL:CVS] is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0005014 name: auditory epithelial support cell namespace: cell def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm] is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002491 ! auditory epithelial cell [Term] id: CL:0005015 name: inner phalangeal cell namespace: cell def: "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." [CL:CVS] xref: FMA:79801 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0005016 name: obsolete apical cell namespace: cell def: "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." [TAIR:TB] comment: replaced_by: PO:0030007 is_obsolete: true [Term] id: CL:0005017 name: obsolete plant basal cell namespace: cell def: "Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote." [TAIR:TB] comment: replaced_by: PO:0002002 is_obsolete: true [Term] id: CL:0005018 name: ghrelin secreting cell namespace: cell def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0036321 ! ghrelin secretion relationship: capable_of GO:0036321 ! ghrelin secretion [Term] id: CL:0005019 name: pancreatic epsilon cell namespace: cell def: "Ghrelin secreting cells found in the found in the exocrine pancreas." [PMID:14970313] comment: In mammals the endocrine pancreas is called the Islets of Langerhans. synonym: "pancreatic E cell" EXACT [] is_a: CL:0005018 ! ghrelin secreting cell [Term] id: CL:0005020 name: lymphangioblast namespace: cell def: "Lymphatic progenitor cells. " [CL:CVS] comment: Usually express Prox1, or prox1b. is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: adjacent_to UBERON:0004536 ! lymph vasculature relationship: adjacent_to UBERON:0004536 ! lymph vasculature created_by: Ceri creation_date: 2012-01-12T04:44:34Z [Term] id: CL:0005021 name: mesenchymal lymphangioblast namespace: cell def: "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." [PMID:15624319, PMID:18430230] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0005020 ! lymphangioblast created_by: Ceri creation_date: 2012-01-12T05:01:22Z [Term] id: CL:0005022 name: vascular lymphangioblast namespace: cell def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [CL:CVS] synonym: "parachordal lymphangioblast" NARROW [] is_a: CL:0005020 {is_inferred="true"} ! lymphangioblast intersection_of: CL:0005020 ! lymphangioblast intersection_of: adjacent_to UBERON:0001638 ! vein relationship: adjacent_to UBERON:0001638 ! vein created_by: Ceri creation_date: 2012-01-12T05:21:09Z [Term] id: CL:0005023 name: branchiomotor neuron def: "Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches." [] {editor="ZFIN:CVS"} synonym: "branchi motor neuron " EXACT [] synonym: "special visceral motor neuron" EXACT [] xref: PMID:14699587 is_a: CL:0015000 ! cranial motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: has_synaptic_terminal_in UBERON:0004164 ! branchiomeric muscle relationship: has_synaptic_terminal_in UBERON:0004164 ! branchiomeric muscle [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [] {editor="ZFIN:CVS"} synonym: "somatic motor neuron" EXACT [] is_a: CL:0000108 ! cholinergic neuron is_a: CL:0008014 ! excitatory motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission relationship: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ [Term] id: CL:0005025 name: visceromotor neuron def: "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." [] {editor="ZFIN:CVS"} comment: Note that these neurons do not synapse directly onto muscles synonym: "general visceral motor neuron" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to to both hepatocytes and cholangiocytes as descendants." [PMID:18356246, PMID:20483998 ] {editor="GOC:CVS"} is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0007000 name: preameloblast namespace: cell def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325] comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008 is_a: CL:0000055 ! non-terminally differentiated cell relationship: adjacent_to UBERON:0001763 ! odontogenic papilla relationship: develops_from CL:0002077 ! ecto-epithelial cell relationship: part_of UBERON:0005176 ! tooth enamel organ created_by: haendel creation_date: 2012-06-15T01:27:01Z [Term] id: CL:0007001 name: skeletogenic cell namespace: cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) synonym: "scleroblast" EXACT [GO_REF:0000034] is_a: CL:0000003 ! native cell created_by: haendel creation_date: 2012-06-15T02:51:27Z [Term] id: CL:0007002 name: precementoblast namespace: cell def: "Skeletogenic cell that has the potential to develop into a cementoblast." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell relationship: part_of UBERON:0005176 ! tooth enamel organ created_by: haendel creation_date: 2012-06-15T04:37:13Z [Term] id: CL:0007003 name: preodontoblast namespace: cell def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0005176 ! tooth enamel organ created_by: haendel creation_date: 2012-06-15T05:15:11Z [Term] id: CL:0007004 name: premigratory neural crest cell namespace: cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] is_a: CL:0000003 ! native cell relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0002342 ! neural crest created_by: haendel creation_date: 2012-06-27T08:27:35Z [Term] id: CL:0007005 name: notochordal cell namespace: cell def: "Cell that is part of the notochord." [GO_REF:0000034] comment: NOTE: TO DO, notochord development still needs work. is_a: CL:0000003 ! native cell relationship: develops_from CL:0007006 ! chordamesodermal cell relationship: part_of UBERON:0002328 ! notochord created_by: haendel creation_date: 2012-06-27T08:47:31Z [Term] id: CL:0007006 name: chordamesodermal cell namespace: cell def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." [GO_REF:0000034] synonym: "axial mesodermal cell" EXACT [] is_a: CL:0000222 ! mesodermal cell relationship: part_of UBERON:0004880 ! chordamesoderm created_by: haendel creation_date: 2012-06-27T08:52:41Z [Term] id: CL:0007007 name: notochordal sheath cell namespace: cell def: "Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells." [CL:MAH] is_a: CL:0007005 ! notochordal cell created_by: haendel creation_date: 2012-06-27T09:26:37Z [Term] id: CL:0007008 name: notochordal vacuole cell namespace: cell def: "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." [CL:MAH] synonym: "chordablast" EXACT [GO_REF:0000034] synonym: "chordoblast" EXACT [PMID:14574572] is_a: CL:0007005 ! notochordal cell created_by: haendel creation_date: 2012-06-27T09:29:30Z [Term] id: CL:0007009 name: prechondroblast namespace: cell def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell created_by: haendel creation_date: 2012-06-27T10:44:01Z [Term] id: CL:0007010 name: preosteoblast namespace: cell def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [GO_REF:0000034] synonym: "osteoprogenitor cell" EXACT [] is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: part_of UBERON:0008883 ! osteoid created_by: haendel creation_date: 2012-06-27T10:57:21Z [Term] id: CL:0007011 name: enteric neuron namespace: cell def: "Neuron that is part of the enteric nervous system." [CL:MAH] is_a: CL:0000029 ! neuron neural crest derived intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002005 ! enteric nervous system relationship: develops_from CL:0002607 ! migratory enteric neural crest cell relationship: part_of UBERON:0002005 ! enteric nervous system created_by: haendel creation_date: 2012-06-28T08:20:31Z [Term] id: CL:0007012 name: non-terminally differentiated odontoblast namespace: cl def: "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." [GO_REF:0000034, PSPUB:0000170] is_a: CL:0000060 ! odontoblast [Term] id: CL:0007013 name: terminally differentiated odontoblast namespace: cl def: "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." [GO_REF:0000034] is_a: CL:0000060 ! odontoblast [Term] id: CL:0007014 name: obsolete cell line cell namespace: cell def: "OBSOLETE: A cultured cell that has been passaged at least one time in culture." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "passaged cultured cell" EXACT [] is_obsolete: true replaced_by: CLO:0000001 created_by: haendel creation_date: 2012-11-28T11:54:59Z [Term] id: CL:0007015 name: obsolete mortal cell line cell namespace: cell def: "OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can)." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'mortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "finite cell line cell" EXACT [] synonym: "primary cell line cell" RELATED [] is_obsolete: true replaced_by: CLO:0000018 created_by: haendel creation_date: 2012-11-28T11:56:20Z [Term] id: CL:0007016 name: adaxial cell namespace: cell def: "Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm." [PMID:8951054] comment: In teleosts, adaxial cells give rise to slow muscle myoblasts. is_a: CL:0000680 ! muscle precursor cell relationship: part_of UBERON:0003059 ! presomitic mesoderm created_by: haendel creation_date: 2012-12-30T12:43:15Z [Term] id: CL:0007017 name: Stiftchenzellen def: "An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis. " [PMID:1087183] comment: Taxon specificity not yet fully known, but are known in anuran larvae but not in adults. is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000362 ! epidermal cell relationship: has_part GO:0005902 ! microvillus relationship: part_of UBERON:0001003 ! skin epidermis created_by: haendel [Term] id: CL:0007018 name: epidermal ciliary cell def: "Ciliated cell of the embryonic epidermis and functions in embryonic movements." [PMCID:PMC3046089] comment: Taxon specificity not clear -present in embryonic anurans. is_a: CL:0000064 ! ciliated cell is_a: CL:0000362 ! epidermal cell is_a: CL:0002321 ! embryonic cell relationship: has_plasma_membrane_part GO:0005929 ! cilium relationship: part_of UBERON:0001003 ! skin epidermis created_by: haendel [Term] id: CL:0007019 name: epidermal mucus secreting cell comment: taxon specificity not clear. Appears in early larval stages of anurans and persists after metamorphosis. is_a: CL:0000319 ! mucus secreting cell created_by: haendel [Term] id: CL:0007020 name: bottle cell def: "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." [PMID:3197630] is_a: CL:0000007 ! early embryonic cell created_by: haendel [Term] id: CL:0007021 name: alarm substance cell def: "Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]" [ISBN-10:0412429403] synonym: "club cell" EXACT [ISBN-10:0412429403] is_a: CL:0000151 ! secretory cell is_a: CL:0000473 ! defensive cell relationship: capable_of GO:0032940 ! secretion by cell relationship: part_of UBERON:0001003 ! skin epidermis created_by: haendel [Term] id: CL:0007022 name: micropylar cell def: "A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg." [PMID:18582455 , ZFA:0005239] synonym: "plug cell" EXACT [] is_a: CL:0000548 ! animal cell relationship: part_of UBERON:0001305 ! ovarian follicle created_by: haendel [Term] id: CL:0007023 name: flask cell def: "Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis. " [DOI:10.1007/BF00717048] is_a: CL:0000003 ! native cell relationship: part_of UBERON:0001003 ! skin epidermis created_by: haendel [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: develops_from CL:0000515 ! skeletal muscle myoblast relationship: has_part GO:0030017 ! sarcomere relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0008003 name: somatic muscle myotube def: "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." [PMID:22274696, PMID:8720463] is_a: CL:0002372 ! myotube is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002478 ! transversely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0008004 name: somatic muscle cell def: "A muscle cell that is part of some somatic muscle." [GOC:dos] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008005 name: obliquely striated somatic muscle cell def: "A somatic muscle cell that is oblquely striated. Examples include the somatic muscles of nematodes." [PMID:8720463] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000444 ! obliquely striated muscle cell is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002479 ! obliquely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0002479 ! obliquely striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0008006 name: muscle founder cell def: "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." [PMID:22274696] is_a: CL:0008018 ! somatic muscle myoblast relationship: develops_into CL:0008003 ! somatic muscle myotube [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle" [GOC:dos] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: bearer_of PATO:0001410 {all_some="true"} ! striated [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: bearer_of PATO:0002478 {all_some="true"} ! transversely striated [Term] id: CL:0008010 name: cranial somatomotor neuron def: "A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue." [PMID:14699587] is_a: CL:0005024 ! somatomotor neuron is_a: CL:0015000 ! cranial motor neuron intersection_of: CL:0015000 ! cranial motor neuron intersection_of: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ relationship: has_synaptic_terminal_in UBERON:0014892 ! skeletal muscle organ [Term] id: CL:0008011 name: skeletal muscle satellite stem cell def: "A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." [PMID:23303905] is_a: CL:0000035 ! single fate stem cell is_a: CL:0000594 ! skeletal muscle satellite cell intersection_of: CL:0000594 ! skeletal muscle satellite cell intersection_of: bearer_of PATO:0001400 ! unipotent intersection_of: capable_of GO:0017145 ! stem cell division disjoint_from: CL:0008020 ! skeletal muscle satellite myogenic cell relationship: bearer_of PATO:0001400 ! unipotent relationship: capable_of GO:0017145 ! stem cell division [Term] id: CL:0008012 name: quiescent skeletal muscle satellite cell def: "A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." [PMID:21849021, PMID:23303905] is_a: CL:0000594 ! skeletal muscle satellite cell [Term] id: CL:0008013 name: cranial visceromotor neuron def: " A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head." [PMID:14699587] is_a: CL:0005025 ! visceromotor neuron is_a: CL:0015000 ! cranial motor neuron [Term] id: CL:0008014 name: excitatory motor neuron def: "A motor neuron that is capable of directly inducing muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. is_a: CL:0000100 ! motor neuron [Term] id: CL:0008015 name: inhibitory motor neuron def: "A motor neuron that is capable of directly inhibiting muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. is_a: CL:0000100 ! motor neuron [Term] id: CL:0008016 name: activated skeletal muscle satellite cell def: "A skeletal muscle cell that has become mitotically active - typically following muscle damage." [PMID:21849021, PMID:23303905] is_a: CL:0000594 ! skeletal muscle satellite cell relationship: develops_from CL:0008012 {comment="More accurately - transformation_of ?"} ! quiescent skeletal muscle satellite cell [Term] id: CL:0008017 name: adult skeletal muscle myoblast def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. synonym: "myogenic precursor cell" BROAD [PMID:23303905] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008002 ! skeletal muscle fiber intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: develops_into CL:0008002 ! skeletal muscle fiber relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0008018 name: somatic muscle myoblast def: "A myoblast that is commited to developing into a somatic muscle." [] is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008003 ! somatic muscle myotube relationship: develops_into CL:0008003 ! somatic muscle myotube [Term] id: CL:0008019 name: mesenchymal cell def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." [] synonym: "mesenchyme cell" EXACT [] is_a: CL:0000219 ! motile cell is_a: CL:0002371 ! somatic cell relationship: capable_of GO:0016477 ! cell migration relationship: part_of UBERON:0003104 ! mesenchyme [Term] id: CL:0008020 name: skeletal muscle satellite myogenic cell def: "A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts." [GOC:dos, PMID:23303905] is_a: CL:0000594 ! skeletal muscle satellite cell relationship: develops_into CL:0008017 ! adult skeletal muscle myoblast [Term] id: CL:0008021 name: anterior lateral line ganglion neuron is_a: CL:2000031 ! lateral line ganglion neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:2001391 ! anterior lateral line ganglion relationship: part_of UBERON:2001391 ! anterior lateral line ganglion [Term] id: CL:0008022 name: endocardial cushion cell def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] is_a: CL:0000569 ! cardiac mesenchymal cell intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: part_of UBERON:0002062 ! endocardial cushion relationship: part_of UBERON:0002062 ! endocardial cushion [Term] id: CL:0008023 name: cardiac fibroblast comment: Duplicate term. is_obsolete: true replaced_by: CL:0002548 [Term] id: CL:0008024 name: pancreatic endocrine cell namespace: cell def: "An endocrine cell that is part of the pancreas." [GOC:dos] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000163 ! endocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0008025 name: noradrenergic neuron def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos] is_a: CL:0000381 ! neurosecretory neuron is_a: CL:0000459 ! noradrenergic cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission [Term] id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] synonym: "spinal sensory neuron" EXACT [] is_a: CL:0000101 {is_inferred="true"} ! sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: part_of UBERON:0001780 ! spinal nerve relationship: part_of UBERON:0001780 ! spinal nerve [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009002 name: inflammatory cell def: "Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Inflammatory_response is_a: CL:0002371 ! somatic cell [Term] id: CL:0009003 name: larval midgut cell def: "Any cell in the midgut (middle subdivision of a digestive tract) of a larva." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Insect#Midgut is_a: CL:0002371 ! somatic cell [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [] xref: GOC:pr xref: PMID:10702418 is_a: CL:0002371 ! somatic cell intersection_of: GO:0005623 ! cell intersection_of: part_of UBERON:0005388 ! photoreceptor array relationship: part_of UBERON:0005388 ! photoreceptor array [Term] id: CL:0009005 name: salivary gland cell def: "Any cell in a salivary gland." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Salivary_gland is_a: CL:0002371 ! somatic cell [Term] id: CL:0010001 name: stromal cell of bone marrow def: "a stromal cell that is part_of a bone marrow" [] synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: GOC:cjm [Term] id: CL:0010002 name: epithelial cell of umbilical artery def: "a epithelial cell that is part_of a umbilical artery" [] synonym: "umbilical artery epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001310 ! umbilical artery relationship: part_of UBERON:0001310 ! umbilical artery created_by: GOC:cjm [Term] id: CL:0010003 name: epithelial cell of alveolus of lung def: "a epithelial cell that is part_of a alveolus of lung" [] comment: May be merged with pneumocyte in future synonym: "alveolus of lung epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung created_by: GOC:cjm [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "a mononuclear cell that is part_of a bone marrow" [] synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: GOC:cjm [Term] id: CL:0010005 name: atrioventricular bundle cell def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell" EXACT [] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0002353 ! atrioventricular bundle relationship: part_of UBERON:0002353 ! atrioventricular bundle [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010007 name: His-Purkinje system cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0004146 ! His-Purkinje system relationship: part_of UBERON:0004146 ! His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010009 name: camera-type eye photoreceptor cell synonym: "camera type eye photoreceptor cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000966 {editor="GOC:cjm"} ! retina [Term] id: CL:0010010 name: cerebellar stellate cell is_a: CL:0000122 ! stellate cell is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000122 ! stellate cell intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0010011 name: cerebral cortex GABAergic interneuron def: "a GABAergic interneuron that is part_of a cerebral cortex" [] is_a: CL:0010012 ! cerebral cortex neuron is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0011005 ! GABAergic interneuron intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0010012 name: cerebral cortex neuron def: "a neuron that is part_of a cerebral cortex" [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0010013 name: type I pinealocyte synonym: "light pinealocyte" EXACT [] is_a: CL:0000652 ! pinealocyte [Term] id: CL:0010014 name: type II pinealocyte synonym: "dark pinealocyte" EXACT [] is_a: CL:0000652 ! pinealocyte [Term] id: CL:0010015 name: coronet cell def: "A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess." [GOC:mr, PMID:17595538] comment: Editor note: remember to link to Saccus vasculosus in next uberon release is_a: CL:0000066 ! epithelial cell [Term] id: CL:0010016 name: collar cell def: "a cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms." [] {comment="http://dx.doi.org/10.1016/j.tree.2015.03.003"} is_a: CL:0000548 ! animal cell relationship: has_part GO:0005929 ! cilium [Term] id: CL:0010020 name: cardiac glial cell is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010021 name: cardiac myoblast is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell relationship: develops_into CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron is_a: CL:0000540 ! neuron is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0011000 name: dorsal horn interneuron def: "A CNS interneuron located in the dorsal horn of the spinal cord." [GOC:nv] synonym: "dorsal spinal cord interneuron" RELATED [] is_a: CL:0002611 ! neuron of the dorsal spinal cord is_a: CL:0005000 {is_inferred="true"} ! spinal cord interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002256 ! dorsal horn of spinal cord relationship: part_of UBERON:0002256 ! dorsal horn of spinal cord [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] is_a: CL:0000100 {is_inferred="true"} ! motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:0011002 name: lateral motor column neuron def: "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [GOC:nv] comment: Need to MIREOT in 'spinal cord lateral column' from Uberon is_a: CL:0011001 ! spinal cord motor neuron [Term] id: CL:0011003 name: magnocellular neurosecretory cell (duplicate class) def: "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that secretes the hormones oxytocin and vasopressin." [GOC:nv, MP:0009467] synonym: "magnocellular neuron" EXACT [] is_a: CL:0000381 ! neurosecretory neuron relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus relationship: part_of UBERON:0006568 ! hypothalamic nucleus [Term] id: CL:0011004 name: lens fiber cell def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GO:0070307, GOC:nv] synonym: "lens fibre cell" EXACT [] is_a: CL:0002222 ! vertebrate lens cell [Term] id: CL:0011005 name: GABAergic interneuron def: "An interneuron that uses GABA as a vesicular neurotransmitter." [GOC:nv] is_a: CL:0000099 ! interneuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000099 ! interneuron intersection_of: CL:0000617 ! GABAergic neuron [Term] id: CL:0011006 name: lugaro cell def: "An inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:nv] synonym: "Lugaro cell" EXACT [] is_a: CL:0011005 ! GABAergic interneuron relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: CL:0011007 name: paraxial cell def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] synonym: "paraxial mesoderm cell" EXACT [] synonym: "presomitic mesoderm cell" NARROW [] synonym: "somitic mesoderm cell" EXACT [] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: part_of UBERON:0003059 ! presomitic mesoderm relationship: part_of UBERON:0003059 ! presomitic mesoderm [Term] id: CL:0011008 name: embryonic hemocyte def: "A hemocyte derived from head mesoderm, which enters the hemolymph as acirculating cell." [GOC:NV, PMID:17967061] is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0011009 name: embryonic plasmatocyte def: "A plasmatocyte derived from head mesoderm." [GOC:NV, PMID:17967061] is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0011010 name: lateral mesodermal cell def: "A cell derived from the mesoderm that is found at the periphery of the embryo." [GOC:NV, PMID:9169844] is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0011011 name: intermediate mesodermal cell def: "A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate." [GOC:NV, ISBN:978-0-87969-707-5] is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0011100 name: galanergic neuron def: "Neuron that secretes the neurotransmitter galanin." [PMID:23159249] {editor="GOC:NV", editor="ZFIN:CVS", editor="ZFIN:YB"} is_a: CL:0000540 ! neuron [Term] id: CL:0011101 name: chorionic trophoblast cell def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV] is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: part_of UBERON:0003124 ! chorion relationship: part_of UBERON:0003124 ! chorion [Term] id: CL:0011102 name: parasympathetic neuron def: "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." [isbn:0080923437] {editor="GOC:NV"} is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0011103 name: sympathetic neuron def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [isbn:0080923437] {editor="GOC:NV"} is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0011104 name: interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer." [PMID:12771169] {editor="GOC:NV"} comment: Need to MIREOT retinal inner nuclear layer (part of) is_a: CL:0000099 ! interneuron relationship: part_of UBERON:0001791 ! inner nuclear layer of retina [Term] id: CL:0011105 name: dopamanergic interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer, using dopamine. " [PMID:12771169] {editor="GOC:NV"} comment: This type of cell is found in Danio rerio. is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0011104 ! interplexiform cell intersection_of: CL:0011104 ! interplexiform cell intersection_of: capable_of GO:0061527 ! dopamine secretion, neurotransmission relationship: capable_of GO:0061527 ! dopamine secretion, neurotransmission [Term] id: CL:0011106 name: GABAnergic interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which \ncarries information from the inner plexiform layer and the outer \nplexiform layer using GABA. " [PMID:12771169] {editor="GOC:NV"} comment: This type of cell is found in many mammals. is_a: CL:0011005 ! GABAergic interneuron is_a: CL:0011104 ! interplexiform cell intersection_of: CL:0011104 ! interplexiform cell intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0011107 name: Muller cell def: "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.\n" [PMID:21911394] {editor="GOC:NV"} synonym: "Muller glia " EXACT [] synonym: "Müller cell" EXACT [] is_a: CL:0000681 ! radial glial cell is_a: CL:0009004 ! retinal cell relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0011108 name: colon epithelial cell def: "Epithelial cell that is part of the colon epithelium. " [] {editor="GOC:NV"} synonym: "colonic epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0001155 ! colon [Term] id: CL:0011109 name: hypocretin-secreting neuron def: "A neuron that releases hypocretin as a neurotransmitter." [PMID:23848055] {editor="GOC:NV"} synonym: "orexin" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061585 ! hypocretin secretion, neurotransmission relationship: capable_of GO:0061585 ! hypocretin secretion, neurotransmission [Term] id: CL:0011110 name: histaminergic neuron def: "Neuron that secretes histamine." [PMID:22677810] {editor="GOC:NV"} is_a: CL:0000381 ! neurosecretory neuron is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061538 ! histamine secretion, neurotransmission relationship: capable_of GO:0061538 ! histamine secretion, neurotransmission [Term] id: CL:0011111 name: gonadotropin releasing neuron def: "Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction." [PMID:21828096] {editor="GOC:NV"} synonym: "GnRH neuron" EXACT [] synonym: "GnRH-secreting neuron" EXACT [] is_a: CL:0000163 ! endocrine cell is_a: CL:0000381 ! neurosecretory neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0032274 ! gonadotropin secretion relationship: capable_of GO:0032274 ! gonadotropin secretion [Term] id: CL:0011112 name: magnocellular neurosecretory cell def: "Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland." [PMID:10711808] {editor="GOC:NV"} is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000381 ! neurosecretory neuron [Term] id: CL:0011113 name: spiral ganglion neuron def: "Neuron found in the spriral ganglion." [] {editor="GOC:NV"} is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000395 ! cochlear ganglion relationship: part_of UBERON:0000395 ! cochlear ganglion [Term] id: CL:0011114 name: segmented neutrophil of bone marrow def: "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." [PMID:11138622, PMID:15514007] is_a: CL:0000096 ! mature neutrophil is_a: CL:1001610 ! bone marrow hematopoietic cell relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: part_of UBERON:0002371 ! bone marrow [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0030154 ! cell differentiation relationship: capable_of GO:0030154 ! cell differentiation [Term] id: CL:0012000 name: astrocyte of the forebrain namespace: cell def: "An astrocyte of the forebrain." [] synonym: "forebrain astrocyte" EXACT [] is_a: CL:0000127 {is_inferred="true"} ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain created_by: tberardini [Term] id: CL:0012001 name: neuron of the forebrain namespace: cell def: "A CNS neuron of the forebrain." [] synonym: "forebrain neuron" EXACT [] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain created_by: tberardini [Term] id: CL:0013000 name: forebrain radial glial cell is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: CL:0015000 name: cranial motor neuron def: "Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. " [] {editor="ZFIN:CVS\n"} synonym: "cranial motoneuron" EXACT [] xref: PMID:14699587 \n is_a: CL:0000100 ! motor neuron [Term] id: CL:1000001 name: retrotrapezoid nucleus neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0009918 ! retrotrapezoid nucleus relationship: part_of UBERON:0009918 ! retrotrapezoid nucleus [Term] id: CL:1000022 name: mesonephric nephron tubule epithelial cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005329 ! mesonephric nephron tubule relationship: part_of UBERON:0005329 ! mesonephric nephron tubule [Term] id: CL:1000042 name: forebrain neuroblast is_a: CL:0000031 ! neuroblast intersection_of: CL:0000031 ! neuroblast intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain [Term] id: CL:1000050 name: lateral line nerve glial cell is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0008906 ! lateral line nerve relationship: part_of UBERON:0008906 ! lateral line nerve [Term] id: CL:1000073 name: spinal cord radial glial cell is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: CL:1000082 name: stretch receptor cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:1000083 name: stratified keratinized epithelial stem cell namespace: cell is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000085 name: stratified non keratinized epithelial stem cell namespace: cell is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000090 name: pronephric nephron tubule epithelial cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005310 ! pronephric nephron tubule relationship: part_of UBERON:0005310 ! pronephric nephron tubule [Term] id: CL:1000123 name: metanephric nephron tubule epithelial cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005146 ! metanephric nephron tubule relationship: part_of UBERON:0005146 ! metanephric nephron tubule [Term] id: CL:1000143 name: lung goblet cell is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0000160 ! goblet cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000147 name: heart valve cell is_a: CL:0000663 ! valve cell intersection_of: CL:0000663 ! valve cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:1000155 name: Malpighian tubule stellate cell def: "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GO:0061330] synonym: "Malpighian tubule Type II cell" EXACT [FBbt:00005797] xref: FBbt:00005797 is_a: CL:0000151 ! secretory cell relationship: part_of UBERON:0001054 ! Malpighian tubule [Term] id: CL:1000182 name: malpighian tubule tip cell is_a: CL:0000423 ! tip cell intersection_of: CL:0000423 ! tip cell intersection_of: part_of UBERON:0001054 ! Malpighian tubule relationship: part_of UBERON:0001054 ! Malpighian tubule [Term] id: CL:1000191 name: pillar cell namespace: cell def: "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." [GOC:tfm, PMID:12417662] synonym: "cochlear pillar cell" RELATED [] synonym: "pillar cell of cochlea" EXACT [] synonym: "pillar cell of corti" EXACT [] synonym: "rod cell of Corti" EXACT [] xref: FMA:75722 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:1000217 name: growth plate cartilage chondrocyte is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: part_of UBERON:0004129 ! growth plate cartilage relationship: part_of UBERON:0004129 ! growth plate cartilage [Term] id: CL:1000222 name: stomach neuroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: CL:1000223 name: lung neuroendocrine cell is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0000165 ! neuroendocrine cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000236 name: posterior lateral line nerve glial cell is_a: CL:1000050 ! lateral line nerve glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:2000175 ! posterior lateral line nerve relationship: part_of UBERON:2000175 ! posterior lateral line nerve [Term] id: CL:1000239 name: anterior lateral line nerve glial cell is_a: CL:1000050 ! lateral line nerve glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:2000425 ! anterior lateral line nerve relationship: part_of UBERON:2000425 ! anterior lateral line nerve [Term] id: CL:1000245 name: posterior lateral line ganglion neuron is_a: CL:2000031 ! lateral line ganglion neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:2001314 ! posterior lateral line ganglion relationship: part_of UBERON:2001314 ! posterior lateral line ganglion [Term] id: CL:1000271 name: lung ciliated cell is_a: CL:0000064 ! ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000272 name: lung secretory cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000274 name: trophectodermal cell namespace: cell synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:1000275 name: smooth muscle cell of small intestine namespace: cell def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050] xref: FMA:15050 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000276 name: smooth muscle fiber of duodenum namespace: cell def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058] xref: FMA:15058 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000277 name: smooth muscle fiber of jejunum namespace: cell def: "A smooth muscle cell that is part of the jejunum." [GOC:tfm] synonym: "non-striated muscle fiber of jejunum" EXACT [FMA:15062] xref: FMA:15062 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000278 name: smooth muscle fiber of ileum namespace: cell def: "A smooth muscle cell that is part of the ileum." [GOC:tfm] synonym: "non-striated muscle fiber of ileum" EXACT [FMA:15066] xref: FMA:15066 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: CL:1000279 name: smooth muscle cell of large intestine namespace: cell def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653] xref: FMA:15653 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine [Term] id: CL:1000280 name: smooth muscle cell of colon namespace: cell def: "A smooth muscle cell that is part of the colon." [GOC:tfm] synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663] xref: FMA:15663 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: CL:1000281 name: smooth muscle cell of cecum namespace: cell def: "A smooth muscle cell that is part of the cecum." [GOC:tfm] synonym: "non-striated muscle fiber of cecum" EXACT [FMA:15681] synonym: "smooth muscle fiber of cecum" EXACT [] xref: FMA:15681 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum [Term] id: CL:1000282 name: smooth muscle fiber of ascending colon namespace: cell def: "A smooth muscle cell that is part of the ascending colon." [GOC:tfm] synonym: "non-striated muscle fiber of ascending colon" EXACT [FMA:17518] xref: FMA:17518 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001156 ! ascending colon relationship: part_of UBERON:0001156 ! ascending colon [Term] id: CL:1000283 name: smooth muscle fiber of transverse colon namespace: cell def: "A smooth muscle cell that is part of the transverse colon." [GOC:tfm] synonym: "non-striated muscle fiber of transverse colon" EXACT [FMA:17519] xref: FMA:17519 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001157 ! transverse colon relationship: part_of UBERON:0001157 ! transverse colon [Term] id: CL:1000284 name: smooth muscle fiber of descending colon namespace: cell def: "A smooth muscle cell that is part of the descending colon." [GOC:tfm] synonym: "non-striated muscle fiber of descending colon" EXACT [FMA:17520] xref: FMA:17520 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001158 ! descending colon relationship: part_of UBERON:0001158 ! descending colon [Term] id: CL:1000285 name: smooth muscle cell of sigmoid colon namespace: cell def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521] xref: FMA:17521 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:0001159 ! sigmoid colon [Term] id: CL:1000286 name: smooth muscle cell of rectum namespace: cell def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522] synonym: "smooth muscle fiber of rectum" EXACT [] xref: FMA:17522 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: CL:1000287 name: myocyte of anterior internodal tract namespace: cell def: "A muscle cell that is part of the anterior internodal tract." [GOC:tfm] xref: FMA:223276 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000288 name: myocyte of atrial branch of anterior internodal tract namespace: cell def: "A muscle cell that is part of the atrial branch of anterior internodal tract." [GOC:tfm] xref: FMA:223277 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000289 name: myocyte of atrial septal branch of anterior internodal tract namespace: cell def: "A muscle cell that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm] xref: FMA:223278 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000290 name: myocyte of middle internodal tract namespace: cell def: "A muscle cell that is part of the middle internodal tract." [GOC:tfm] xref: FMA:223279 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000291 name: myocyte of posterior internodal tract namespace: cell def: "A muscle cell that is part of the posterior internodal tract." [GOC:tfm] xref: FMA:223280 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000296 name: epithelial cell of urethra namespace: cell def: "An epithelial cell that is part of the urethra." [GOC:tfm] xref: FMA:256165 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell is_a: CL:1001320 ! urethra cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: CL:1000298 name: mesothelial cell of dura mater namespace: cell def: "A mesothelial cell that is part of the dura mater." [GOC:tfm] synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516] xref: FMA:256516 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002363 ! dura mater relationship: part_of UBERON:0002363 ! dura mater [Term] id: CL:1000299 name: fibroblast of connective tissue of prostate namespace: cell def: "A fibroblast that is part of the connective tissue of prostate." [GOC:tfm] xref: FMA:261271 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000300 name: fibroblast of outer membrane of prostatic capsule namespace: cell def: "A fibroblast that is part of the outer membrane of prostatic capsule." [GOC:tfm] xref: FMA:261273 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000301 name: fibroblast of subepithelial connective tissue of prostatic gland namespace: cell def: "A fibroblast that is part of the subepithelial connective tissue of prostatic gland." [GOC:tfm] xref: FMA:261275 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000302 name: fibroblast of papillary layer of dermis namespace: cell def: "A fibroblast that is part of the papillary layer of dermis." [GOC:tfm] xref: FMA:261277 is_a: CL:0002551 {is_inferred="true"} ! fibroblast of dermis intersection_of: CL:0002551 ! fibroblast of dermis intersection_of: part_of UBERON:0001992 ! papillary layer of dermis relationship: part_of UBERON:0001992 ! papillary layer of dermis [Term] id: CL:1000303 name: fibroblast of areolar connective tissue namespace: cell def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] xref: FMA:261279 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0006815 ! areolar connective tissue relationship: part_of UBERON:0006815 ! areolar connective tissue [Term] id: CL:1000304 name: fibroblast of connective tissue of nonglandular part of prostate namespace: cell def: "A fibroblast that is part of the connective tissue of nonglandular part of prostate." [GOC:tfm] xref: FMA:261281 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000305 name: fibroblast of connective tissue of glandular part of prostate namespace: cell def: "A fibroblast that is part of the connective tissue of glandular part of prostate." [GOC:tfm] xref: FMA:261283 is_a: CL:0000057 ! fibroblast relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery namespace: cell def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] xref: FMA:261285 is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue namespace: cell def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0007846 ! dense regular connective tissue relationship: part_of UBERON:0002521 ! elastic tissue relationship: part_of UBERON:0007846 ! dense regular connective tissue [Term] id: CL:1000308 name: fibrocyte of adventitia of ureter namespace: cell def: "A fibrocyte that is part of the adventitia of ureter." [GOC:tfm] xref: FMA:261289 is_a: CL:0000135 {is_inferred="true"} ! fibrocyte is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000135 ! fibrocyte intersection_of: part_of UBERON:0001252 ! adventitia of ureter relationship: part_of UBERON:0001252 ! adventitia of ureter [Term] id: CL:1000309 name: epicardial adipocyte namespace: cell def: "A fat cell that is part of the epicardial fat." [GOC:tfm] synonym: "adipocyte of epicardial fat" EXACT [FMA:261293] synonym: "epicardial fat cell" EXACT [FMA:261293] xref: FMA:261293 is_a: CL:0000136 ! fat cell relationship: part_of UBERON:0002348 ! epicardium [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle namespace: cell def: "A fat cell that is part of the epicardial fat of right ventricle." [GOC:tfm] synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297] synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297] xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle namespace: cell def: "A fat cell that is part of the epicardial fat of left ventricle." [GOC:tfm] synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300] synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300] xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: CL:1000312 name: bronchial goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of bronchus." [GOC:tfm] synonym: "goblet cell of epithelium of bronchus" EXACT [FMA:263032] xref: FMA:263032 is_a: CL:0000160 ! goblet cell is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: CL:1000313 name: gastric goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of stomach." [GOC:tfm] synonym: "goblet cell of epithelium of stomach" EXACT [FMA:263035] xref: FMA:263035 is_a: CL:0000160 ! goblet cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001276 ! epithelium of stomach [Term] id: CL:1000314 name: gastric cardiac gland goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of gastric cardiac gland." [GOC:tfm] synonym: "goblet cell of epithelium of gastric cardiac gland" EXACT [] xref: FMA:263038 is_a: CL:0000152 ! exocrine cell is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0008859 ! cardiac gastric gland relationship: part_of UBERON:0008859 ! cardiac gastric gland [Term] id: CL:1000315 name: principal gastric gland goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of principal gastric gland." [GOC:tfm] synonym: "goblet cell of epithelium of principal gastric gland" EXACT [] xref: FMA:263040 is_a: CL:0000152 ! exocrine cell is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0009971 ! principal gastric gland relationship: part_of UBERON:0009971 ! principal gastric gland [Term] id: CL:1000316 name: obsolete goblet cell of epithelium of small intestine namespace: cell def: "OBSOLETE: A goblet cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263042 is_obsolete: true replaced_by: CL:1000495 [Term] id: CL:1000317 name: intestinal villus goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of intestinal villus." [GOC:tfm] synonym: "goblet cell of epithelium of intestinal villus" EXACT [] xref: FMA:263046 is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000318 name: obsolete small intestine crypt goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263050 is_obsolete: true [Term] id: CL:1000319 name: obsolete goblet cell of epithelium proper of small intestine namespace: cell def: "OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263052 is_obsolete: true [Term] id: CL:1000320 name: large intestine goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of large intestine." [GOC:tfm] synonym: "goblet cell of epithelium of large intestine" EXACT [] xref: FMA:263054 is_a: CL:0000160 ! goblet cell is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine [Term] id: CL:1000321 name: large intestine crypt goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of large intestine." [GOC:tfm] xref: FMA:263056 is_a: CL:1000320 ! large intestine goblet cell [Term] id: CL:1000322 name: pancreatic goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of pancreatic duct." [GOC:tfm] synonym: "goblet cell of epithelium of pancreatic duct" EXACT [FMA:263058] xref: FMA:263058 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0009970 ! epithelium of pancreatic duct [Term] id: CL:1000323 name: pylroric gastric gland goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of pyloric gland." [GOC:tfm] synonym: "goblet cell of epithelium of pyloric gland" EXACT [] xref: FMA:263061 is_a: CL:0000152 ! exocrine cell is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0008861 ! pyloric gastric gland relationship: part_of UBERON:0008861 ! pyloric gastric gland [Term] id: CL:1000324 name: duodenal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of duodenum." [GOC:tfm] synonym: "goblet cell of epithelium proper of duodenum" EXACT [] xref: FMA:263063 is_a: CL:0000160 ! goblet cell is_a: CL:1001589 ! duodenum glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1000325 name: jejunal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of jejunum." [GOC:tfm] synonym: "goblet cell of epithelium proper of jejunum" EXACT [] xref: FMA:263065 is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000326 name: ileal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of ileum." [GOC:tfm] synonym: "goblet cell of epithelium proper of ileum" EXACT [] xref: FMA:263067 is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: CL:1000327 name: appendix goblet cell namespace: cell def: "A goblet cell that is part of the epithelium proper of appendix." [GOC:tfm] synonym: "goblet cell of epithelium proper of appendix" EXACT [] xref: FMA:263069 is_a: CL:0000160 ! goblet cell is_a: CL:1001585 ! appendix glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: CL:1000328 name: obsolete goblet cell of epithelium proper of large intestine namespace: cell def: "OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine." [GOC:tfm] xref: FMA:263071 is_obsolete: true [Term] id: CL:1000329 name: tracheal goblet cell namespace: cell def: "A goblet cell that is part of the epithelium of trachea." [GOC:tfm] synonym: "goblet cell of epithelium of trachea" EXACT [FMA:263075] xref: FMA:263075 is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:0002370 ! respiratory goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:1000330 name: serous cell of epithelium of trachea namespace: cell def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] xref: FMA:263078 is_a: CL:0000313 {is_inferred="true"} ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea [Term] id: CL:1000331 name: serous cell of epithelium of bronchus namespace: cell def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] xref: FMA:263080 is_a: CL:0000313 ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus [Term] id: CL:1000332 name: serous cell of epithelium of terminal bronchiole namespace: cell def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] xref: FMA:263082 is_a: CL:1000333 ! serous cell of epithelium of lobular bronchiole intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium [Term] id: CL:1000333 name: serous cell of epithelium of lobular bronchiole namespace: cell def: "A serous secreting cell that is part of the epithelium of bronchiole." [GOC:tfm] xref: FMA:263084 is_a: CL:1000331 ! serous cell of epithelium of bronchus intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole [Term] id: CL:1000334 name: enterocyte of epithelium of small intestine namespace: cell def: "An enterocyte that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263086 is_a: CL:0000584 {is_inferred="true"} ! enterocyte intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1000335 name: enterocyte of epithelium of intestinal villus namespace: cell def: "An enterocyte that is part of the epithelium of intestinal villus." [GOC:tfm] xref: FMA:263088 is_a: CL:1000334 ! enterocyte of epithelium of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0013636 ! epithelium of intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000337 name: enterocyte of epithelium of duodenal gland namespace: cell def: "An enterocyte that is part of the epithelium of duodenal gland." [GOC:tfm] xref: FMA:263092 is_a: CL:0000584 ! enterocyte intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001212 ! duodenal gland relationship: part_of UBERON:0001212 ! duodenal gland [Term] id: CL:1000338 name: enterocyte of epithelium of crypt of lieberkuhn of small intestine namespace: cell def: "An enterocyte that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263094 is_a: CL:1000334 ! enterocyte of epithelium of small intestine relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn [Term] id: CL:1000339 name: enterocyte of epithelium proper of small intestine namespace: cell def: "An enterocyte that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263096 is_a: CL:1000334 ! enterocyte of epithelium of small intestine [Term] id: CL:1000340 name: enterocyte of epithelium proper of duodenum namespace: cell def: "An enterocyte that is part of the epithelium proper of duodenum." [GOC:tfm] xref: FMA:263098 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine relationship: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000341 name: enterocyte of epithelium proper of jejunum namespace: cell def: "An enterocyte that is part of the epithelium proper of jejunum." [GOC:tfm] xref: FMA:263100 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine [Term] id: CL:1000342 name: enterocyte of epithelium proper of ileum namespace: cell def: "An enterocyte that is part of the epithelium proper of ileum." [GOC:tfm] xref: FMA:263102 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine [Term] id: CL:1000343 name: paneth cell of epithelium of small intestine namespace: cell def: "A paneth cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263104 is_a: CL:0000510 {is_inferred="true"} ! paneth cell is_a: CL:0002254 {is_inferred="true"} ! epithelial cell of small intestine is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1000344 name: paneth cell of epithelium proper of small intestine namespace: cell def: "A Paneth cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263106 is_a: CL:1000343 ! paneth cell of epithelium of small intestine [Term] id: CL:1000345 name: paneth cell of epithelium of crypt of lieberkuhn of small intestine namespace: cell def: "A Paneth cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263108 is_a: CL:1000343 ! paneth cell of epithelium of small intestine relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn [Term] id: CL:1000346 name: vacuolar absorptive cell of epithelium proper of large intestine namespace: cell alt_id: CL:1000336 def: "MERGED DEFINITION: TARGET DEFINITION: A columnar cell of the colon that is part of the epithelium proper of large intestine. SOURCE DEFINITION: An enterocyte that is part of the epithelium proper of large intestine." [GOC:tfm] synonym: "enterocyte of epithelium proper of large intestine" EXACT [] xref: FMA:263090 xref: FMA:263112 is_a: CL:0002071 ! enterocyte of epithelium of large intestine [Term] id: CL:1000347 name: vacuolar absorptive cell of epithelium of colon namespace: cell def: "A columnar cell of the colon that is part of the colonic epithelium." [GOC:tfm] xref: FMA:263114 is_a: CL:0002071 {is_inferred="true"} ! enterocyte of epithelium of large intestine intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine intersection_of: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0000397 ! colonic epithelium [Term] id: CL:1000348 name: basal cell of epithelium of trachea namespace: cell def: "A basal cell that is part of the epithelium of trachea." [GOC:tfm] xref: FMA:263118 is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea [Term] id: CL:1000349 name: basal cell of epithelium of bronchus namespace: cell alt_id: CL:0002331 def: "A basal cell found in the bronchus epithelium." [GOC:tfm] synonym: "basal cell of bronchus" EXACT [] xref: FMA:263120 is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree is_a: CL:0002633 ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus [Term] id: CL:1000350 name: basal cell of epithelium of terminal bronchiole namespace: cell def: "A basal cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] xref: FMA:263122 is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium [Term] id: CL:1000351 name: basal cell of epithelium of respiratory bronchiole namespace: cell def: "A basal cell that is part of the epithelium of respiratory bronchiole." [GOC:tfm] xref: FMA:263124 is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole [Term] id: CL:1000352 name: basal cell of epithelium of lobular bronchiole namespace: cell def: "A basal cell that is part of the epithelium of bronchiole." [GOC:tfm] xref: FMA:263126 is_a: CL:1000349 ! basal cell of epithelium of bronchus intersection_of: CL:0002633 ! respiratory basal cell intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole [Term] id: CL:1000353 name: microfold cell of epithelium of small intestine namespace: cell def: "A M cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263128 is_a: CL:0000682 {is_inferred="true"} ! M cell of gut intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000354 name: microfold cell of epithelium of intestinal villus namespace: cell def: "A M cell that is part of the epithelium of intestinal villus." [GOC:tfm] xref: FMA:263130 is_a: CL:0000682 ! M cell of gut intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000355 name: microfold cell of epithelium proper of small intestine namespace: cell def: "A M cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263132 is_a: CL:1000353 ! microfold cell of epithelium of small intestine [Term] id: CL:1000356 name: microfold cell of epithelium proper of duodenum namespace: cell def: "A M cell that is part of the epithelium proper of duodenum." [GOC:tfm] xref: FMA:263134 is_a: CL:0000682 ! M cell of gut intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1000357 name: microfold cell of epithelium proper of jejunum namespace: cell def: "A M cell that is part of the epithelium proper of jejunum." [GOC:tfm] xref: FMA:263136 is_a: CL:0000682 ! M cell of gut intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000358 name: microfold cell of epithelium proper of ileum namespace: cell def: "A M cell that is part of the epithelium proper of ileum." [GOC:tfm] xref: FMA:263138 is_a: CL:0000682 ! M cell of gut intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum [Term] id: CL:1000359 name: microfold cell of epithelium proper of appendix namespace: cell def: "A M cell that is part of the epithelium proper of appendix." [GOC:tfm] xref: FMA:263140 is_a: CL:0000682 ! M cell of gut is_a: CL:1000405 ! epithelial cell of appendix is_a: UBERON:0009697 ! epithelium of appendix intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: CL:1000360 name: microfold cell of epithelium proper of large intestine namespace: cell def: "A M cell that is part of the epithelium proper of large intestine." [GOC:tfm] xref: FMA:263142 is_a: CL:0000682 ! M cell of gut is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine [Term] id: CL:1000361 name: transitional myocyte of interatrial septum namespace: cell def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] xref: FMA:263152 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum native cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002085 ! interatrial septum relationship: part_of UBERON:0002085 ! interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum namespace: cell def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263154 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum native cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000363 name: transitional myocyte of atrial branch of anterior internodal tract namespace: cell def: "A transitional myocyte that is part of the atrial branch of anterior internodal tract." [GOC:tfm] xref: FMA:263156 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000364 name: transitional myocyte of anterior internodal tract namespace: cell def: "A transitional myocyte that is part of the anterior internodal tract." [GOC:tfm] xref: FMA:263158 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000365 name: transitional myocyte of atrial septal branch of anterior internodal tract namespace: cell def: "A transitional myocyte that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm] xref: FMA:263160 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000366 name: transitional myocyte of middle internodal tract namespace: cell def: "A transitional myocyte that is part of the middle internodal tract." [GOC:tfm] xref: FMA:263162 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000367 name: transitional myocyte of posterior internodal tract namespace: cell def: "A transitional myocyte that is part of the posterior internodal tract." [GOC:tfm] xref: FMA:263164 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000368 name: transitional myocyte of anterior division of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263166 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000369 name: transitional myocyte of septal division of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263168 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000370 name: transitional myocyte of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263170 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0005986 ! left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000371 name: transitional myocyte of right branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the right branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263172 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0005987 ! right branch of atrioventricular bundle relationship: part_of UBERON:0005987 ! right branch of atrioventricular bundle [Term] id: CL:1000372 name: transitional myocyte of atrial part of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the atrial part of atrioventricular bundle." [GOC:tfm] xref: FMA:263174 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle [Term] id: CL:1000373 name: transitional myocyte of ventricular part of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the ventricular part of atrioventricular bundle." [GOC:tfm] xref: FMA:263176 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle [Term] id: CL:1000374 name: transitional myocyte of posterior division of left branch of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263178 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000375 name: myocardial endocrine cell of septal division of left branch of atrioventricular bundle namespace: cell def: "A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm] xref: FMA:263180 is_a: CL:0002074 ! myocardial endocrine cell relationship: part_of UBERON:0005986 ! left branch of atrioventricular bundle [Term] id: CL:1000376 name: purkinje myocyte of interventricular septum namespace: cell def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263182 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum native cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000377 name: dense-core granulated cell of epithelium of trachea namespace: cell def: "A Feyrter cell that is part of the epithelium of trachea." [GOC:tfm] xref: FMA:263184 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002066 {is_inferred="true"} ! Feyrter cell intersection_of: CL:0002066 ! Feyrter cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea [Term] id: CL:1000378 name: type 1 vestibular sensory cell of stato-acoustic epithelium namespace: cell def: "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm] xref: FMA:263186 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002070 ! type I vestibular sensory cell intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: part_of UBERON:0009969 ! stato-acoustic epithelium relationship: part_of UBERON:0009969 ! stato-acoustic epithelium [Term] id: CL:1000379 name: type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth namespace: cell def: "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm] xref: FMA:263188 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002070 ! type I vestibular sensory cell intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth relationship: part_of UBERON:0003241 ! epithelium of utricle [Term] id: CL:1000380 name: type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth namespace: cell def: "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm] xref: FMA:263190 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002070 ! type I vestibular sensory cell intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth relationship: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth relationship: part_of UBERON:0003242 ! epithelium of saccule [Term] id: CL:1000381 name: type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth namespace: cell def: "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm] xref: FMA:263192 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002070 ! type I vestibular sensory cell intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium [Term] id: CL:1000382 name: type 2 vestibular sensory cell of stato-acoustic epithelium namespace: cell def: "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm] xref: FMA:263194 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002069 ! type II vestibular sensory cell intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: part_of UBERON:0009969 ! stato-acoustic epithelium relationship: part_of UBERON:0009969 ! stato-acoustic epithelium [Term] id: CL:1000383 name: type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth namespace: cell def: "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm] xref: FMA:263196 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002069 ! type II vestibular sensory cell intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth relationship: part_of UBERON:0003241 ! epithelium of utricle [Term] id: CL:1000384 name: type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth namespace: cell def: "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm] xref: FMA:263198 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002069 ! type II vestibular sensory cell intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth relationship: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth relationship: part_of UBERON:0003242 ! epithelium of saccule [Term] id: CL:1000385 name: type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth namespace: cell def: "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm] xref: FMA:263200 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0002069 ! type II vestibular sensory cell intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium [Term] id: CL:1000391 name: melanocyte of eyelid namespace: cell def: "A melanocyte that is part of the eyelid." [GOC:tfm] synonym: "eyelid melanocyte" EXACT [FMA:59175] synonym: "sebaceous gland of wolff" EXACT [FMA:59175] xref: FMA:59175 is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] id: CL:1000394 name: myoepithelial cell of intralobular lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct." [GOC:tfm] xref: FMA:62158 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000397 name: endothelial cell of venous sinus of red pulp of spleen namespace: cell def: "An endothelial cell that is part of the venous sinus of red pulp of spleen." [GOC:tfm] comment: todo - add logical definition to UBERON:0009967 xref: FMA:62817 is_a: CL:0002651 ! endothelial cell of venous sinus of spleen intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0009967 ! spleen venous sinus relationship: part_of UBERON:0009967 ! spleen venous sinus [Term] id: CL:1000398 name: endothelial cell of hepatic sinusoid namespace: cell def: "An endothelial cell that is part of the hepatic sinusoid." [GOC:tfm] synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911] xref: FMA:62911 is_a: CL:0002262 {is_inferred="true"} ! endothelial cell of sinusoid intersection_of: CL:0002262 ! endothelial cell of sinusoid intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: part_of UBERON:0001281 ! hepatic sinusoid [Term] id: CL:1000405 name: epithelial cell of appendix namespace: cell def: "An epithelial cell that is part of the appendix." [GOC:tfm] synonym: "columnar epitheliocyte of appendix" EXACT [FMA:63602] synonym: "epithelial cell of vermiform appendix" EXACT [FMA:63602] xref: FMA:63602 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix [Term] id: CL:1000409 name: myocyte of sinoatrial node namespace: cell def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] synonym: "myocyte of sinoatrial node" EXACT [FMA:67102] synonym: "SA nodal myocyte" EXACT [FMA:67102] synonym: "SA node cardiac muscle cell" EXACT [GOC:pr] synonym: "sinoatrial node cell" EXACT [GOC:pr] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [FMA:67102] xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002351 ! sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node namespace: cell def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] synonym: "atrioventricular node cell" EXACT [GOC:pr] synonym: "atrioventricular node myocyte" EXACT [FMA:67106] synonym: "AV nodal myocyte" EXACT [FMA:67106] synonym: "AV node cardiac muscle cell" EXACT [GOC:pr] synonym: "AV node cell" EXACT [GOC:pr] xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002352 ! atrioventricular node relationship: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000411 name: endothelial cell of peyer's patch namespace: cell def: "An endothelial cell that is part of the small intestine Peyer's patch." [GOC:tfm] xref: FMA:67757 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003454 ! small intestine Peyer's patch relationship: part_of UBERON:0003454 ! small intestine Peyer's patch [Term] id: CL:1000412 name: endothelial cell of arteriole namespace: cell def: "An endothelial cell that is part of the arteriole." [GOC:tfm] xref: FMA:67760 xref: KUPO:0001097 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole [Term] id: CL:1000413 name: endothelial cell of artery namespace: cell alt_id: CL:0002542 def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001917 ! endothelium of artery [Term] id: CL:1000414 name: endothelial cell of venule namespace: cell def: "An endothelial cell that is part of the venule." [GOC:tfm] xref: FMA:67762 is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule [Term] id: CL:1000415 name: epithelial cell of gall bladder namespace: cell def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] xref: FMA:67780 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002110 ! gall bladder relationship: part_of UBERON:0002110 ! gall bladder [Term] id: CL:1000416 name: myoepithelial cell of lactiferous gland namespace: cell def: "A myoepithelial cell that is part of the mammary gland." [GOC:tfm] synonym: "basal cell of lactiferous duct" EXACT [FMA:67800] xref: CALOHA:TS-2378 xref: FMA:67800 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] id: CL:1000417 name: myoepithelial cell of sweat gland namespace: cell def: "A myoepithelial cell that is part of the sweat gland." [GOC:tfm] xref: FMA:67801 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001820 ! sweat gland relationship: part_of UBERON:0001820 ! sweat gland [Term] id: CL:1000418 name: myoepithelial cell of lactiferous alveolus namespace: cell def: "A myoepithelial cell that is part of the mammary gland alveolus." [GOC:tfm] synonym: "basal cell of alveolus of lactiferous gland" EXACT [FMA:67802] synonym: "myoepithelial cell of mammary alveolus" EXACT [FMA:67802] xref: FMA:67802 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0003214 ! mammary gland alveolus relationship: part_of UBERON:0003214 ! mammary gland alveolus [Term] id: CL:1000419 name: myoepithelial cell of lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the lactiferous duct." [GOC:tfm] xref: FMA:67803 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001765 ! mammary duct relationship: part_of UBERON:0001765 ! mammary duct [Term] id: CL:1000420 name: myoepithelial cell of terminal lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the terminal lactiferous duct." [GOC:tfm] xref: FMA:67804 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000424 name: chromaffin cell of paraaortic body namespace: cell def: "A chromaffin cell that is part of the paraaortic body." [GOC:tfm] synonym: "chromaffin cell of para-aortic body" EXACT [FMA:69328] xref: FMA:69328 is_a: CL:1000425 ! chromaffin cell of paraganglion intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001237 ! paraaortic body relationship: part_of UBERON:0001237 ! paraaortic body [Term] id: CL:1000425 name: chromaffin cell of paraganglion namespace: cell def: "A chromaffin cell that is part of the paraganglion." [GOC:tfm] xref: FMA:69335 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0012279 ! chromaffin paraganglion relationship: part_of UBERON:0012279 ! chromaffin paraganglion [Term] id: CL:1000426 name: chromaffin cell of adrenal gland namespace: cell def: "A chromaffin cell that is part of the adrenal gland." [GOC:tfm] synonym: "adrenal chromaffin cell" EXACT [GO:0061104] xref: FMA:69794 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002369 ! adrenal gland relationship: part_of UBERON:0002369 ! adrenal gland [Term] id: CL:1000427 name: adrenal cortex chromaffin cell namespace: cell def: "A chromaffin cell that is part of the adrenal cortex." [GOC:tfm] comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin. synonym: "chromaffin cell of adrenal cortex" EXACT [] xref: FMA:69795 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: CL:1000428 name: stem cell of epidermis namespace: cell def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis [Term] id: CL:1000432 name: conjunctival epithelial cell namespace: cell def: "An epithelial cell that is part of the conjunctiva." [GOC:tfm] synonym: "epithelial cell of conjunctiva" EXACT [FMA:70552] xref: FMA:70552 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva [Term] id: CL:1000433 name: epithelial cell of lacrimal canaliculus namespace: cell def: "An epithelial cell that is part of the lacrimal canaliculus." [GOC:tfm] xref: FMA:70553 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001770 ! lacrimal canaliculus relationship: part_of UBERON:0001770 ! lacrimal canaliculus [Term] id: CL:1000434 name: epithelial cell of external acoustic meatus namespace: cell def: "An epithelial cell that is part of the external acoustic meatus." [GOC:tfm] xref: FMA:70555 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001352 ! external acoustic meatus relationship: part_of UBERON:0001352 ! external acoustic meatus [Term] id: CL:1000435 name: epithelial cell of lacrimal duct namespace: cell def: "An epithelial cell that is part of the lacrimal duct." [GOC:tfm] xref: FMA:70559 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0001850 ! lacrimal drainage system relationship: part_of UBERON:0001850 ! lacrimal drainage system [Term] id: CL:1000436 name: epithelial cell of lacrimal sac namespace: cell def: "An epithelial cell that is part of the lacrimal sac." [GOC:tfm] xref: FMA:70560 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001351 ! lacrimal sac relationship: part_of UBERON:0001351 ! lacrimal sac [Term] id: CL:1000437 name: epithelial cell of nasolacrimal duct namespace: cell def: "An epithelial cell that is part of the nasolacrimal duct." [GOC:tfm] xref: FMA:70561 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0002392 ! nasolacrimal duct relationship: part_of UBERON:0002392 ! nasolacrimal duct [Term] id: CL:1000438 name: epithelial cell of wall of inferior part of anal canal namespace: cell def: "An epithelial cell that is part of the wall of inferior part of anal canal." [GOC:tfm] xref: FMA:70562 is_a: CL:0002634 ! epithelial cell of anal column [Term] id: CL:1000441 name: epithelial cell of viscerocranial mucosa namespace: cell def: "An epithelial cell that is part of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70583 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:1000442 name: urothelial cell of trigone of urinary bladder namespace: cell def: "An urothelial cell that is part of the trigone of urinary bladder." [GOC:tfm] synonym: "epithelial cell of vesical trigone" EXACT [FMA:70598] xref: FMA:70598 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder relationship: part_of UBERON:0001257 ! trigone of urinary bladder [Term] id: CL:1000443 name: ciliary muscle cell namespace: cell def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610] xref: FMA:70610 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001775 ! ciliary body relationship: part_of UBERON:0001775 ! ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye namespace: cell def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] xref: FMA:70615 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 ! anterior chamber of eyeball [Term] id: CL:1000445 name: myoepithelial cell of dilator pupillae namespace: cell def: "A myoepithelial cell that is part of the dilatator pupillae." [GOC:tfm] xref: FMA:70619 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001608 ! dilatator pupillae relationship: part_of UBERON:0001608 ! dilatator pupillae [Term] id: CL:1000447 name: epithelial cell of stratum germinativum of esophagus namespace: cell def: "A basal cell that is part of the epithelium of esophagus." [GOC:tfm] synonym: "basal cell of esophageal epithelium" EXACT [FMA:70731] xref: FMA:70731 is_a: CL:0000646 {is_inferred="true"} ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001976 ! epithelium of esophagus relationship: part_of UBERON:0001976 ! epithelium of esophagus [Term] id: CL:1000448 name: epithelial cell of sweat gland namespace: cell def: "An epithelial cell that is part of the sweat gland." [GOC:tfm] xref: FMA:70952 is_a: CL:0002308 ! epithelial cell of skin gland intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001820 ! sweat gland relationship: part_of UBERON:0001820 ! sweat gland [Term] id: CL:1000449 name: epithelial cell of nephron namespace: cell def: "An epithelial cell that is part of the nephron." [GOC:tfm] xref: FMA:70965 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001285 ! nephron relationship: part_of UBERON:0001285 ! nephron [Term] id: CL:1000450 name: epithelial cell of glomerular capsule namespace: cell def: "An epithelial cell that is part of the glomerular capsule." [GOC:tfm] synonym: "Bowmans capsule epithelial cell" EXACT [] synonym: "epithelial cell of Bowman's capsule" EXACT [FMA:70966] xref: FMA:70966 xref: KUPO:0001034 is_a: CL:1000510 ! kidney glomerular epithelial cell is_a: CL:1000612 {is_inferred="true"} ! kidney corpuscule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001230 ! glomerular capsule relationship: part_of UBERON:0001230 ! glomerular capsule [Term] id: CL:1000451 name: epithelial cell of visceral layer of glomerular capsule namespace: cell def: "An epithelial cell that is part of the visceral layer of glomerular capsule." [GOC:tfm] comment: consider merging into CL:0000653 synonym: "glomerular podocyte" NARROW [FMA:70967] xref: FMA:70967 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005751 ! visceral layer of glomerular capsule relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule [Term] id: CL:1000452 name: parietal epithelial cell namespace: cell alt_id: CL:1000897 def: "An epithelial cell that is part of the glomerular parietal epithelium." [GOC:tfm] synonym: "epithelial cell of parietal layer of glomerular capsule" EXACT [FMA:70968] xref: FMA:70968 xref: KUPO:0001035 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0005750 ! glomerular parietal epithelium relationship: part_of UBERON:0005750 ! glomerular parietal epithelium [Term] id: CL:1000453 name: epithelial cell of intermediate tubule namespace: cell def: "An epithelial cell that is part of the intermediate tubule." [GOC:tfm] xref: FMA:70980 is_a: CL:0002371 {is_inferred="true"} ! somatic cell is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: part_of UBERON:0004136 ! intermediate tubule relationship: part_of UBERON:0004136 ! intermediate tubule [Term] id: CL:1000454 name: kidney collecting duct epithelial cell namespace: cell def: "An epithelial cell that is part of the collecting duct of renal tubule." [GOC:tfm] synonym: "epithelial cell of renal collecting tubule" EXACT [FMA:70982] xref: FMA:70982 xref: KUPO:0001059 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum namespace: cell def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] xref: FMA:72142 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001366 ! parietal peritoneum relationship: part_of UBERON:0001366 ! parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum namespace: cell def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] xref: FMA:72143 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001178 ! visceral peritoneum relationship: part_of UBERON:0001178 ! visceral peritoneum [Term] id: CL:1000458 name: melanocyte of skin namespace: cell def: "A melanocyte that is part of the skin of body." [GOC:tfm] synonym: "skin melanocyte" EXACT [FMA:72144] xref: CALOHA:TS-2374 xref: FMA:72144 is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body [Term] id: CL:1000465 name: chromaffin cell of ovary namespace: cell def: "A chromaffin cell that is part of the ovary." [GOC:tfm] xref: FMA:74319 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell is_a: CL:2000064 ! ovarian surface epithelial cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad [Term] id: CL:1000466 name: chromaffin cell of right ovary namespace: cell def: "A chromaffin cell that is part of the right ovary." [GOC:tfm] xref: FMA:74320 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002118 ! right ovary relationship: part_of UBERON:0002118 ! right ovary [Term] id: CL:1000467 name: chromaffin cell of left ovary namespace: cell def: "A chromaffin cell that is part of the left ovary." [GOC:tfm] xref: FMA:74321 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002119 ! left ovary relationship: part_of UBERON:0002119 ! left ovary [Term] id: CL:1000468 name: myoepithelial cell of acinus of lactiferous gland namespace: cell def: "A myoepithelial cell that is part of the acinus of lactiferous gland." [GOC:tfm] synonym: "basal cell of acinus of lactiferous gland" EXACT [FMA:74469] xref: FMA:74469 is_a: CL:0000185 ! myoepithelial cell relationship: part_of UBERON:0001912 ! lobule of mammary gland [Term] id: CL:1000469 name: myoepithelial cell of main lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the main lactiferous duct." [GOC:tfm] xref: FMA:74499 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000470 name: myoepithelial cell of primary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the primary lactiferous duct." [GOC:tfm] xref: FMA:74500 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000471 name: myoepithelial cell of secondary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the secondary lactiferous duct." [GOC:tfm] xref: FMA:74501 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000472 name: myoepithelial cell of tertiary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the tertiary lactiferous duct." [GOC:tfm] xref: FMA:74502 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000473 name: myoepithelial cell of quarternary lactiferous duct namespace: cell def: "A myoepithelial cell that is part of the quarternary lactiferous duct." [GOC:tfm] xref: FMA:74503 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000477 name: cardiac pacemaker cell of sinoatrial node namespace: cell def: "A nodal myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "cardiac pacemaker cell of sinuatrial node" EXACT [] synonym: "pacemaker cell of sinoatrial node" EXACT [] synonym: "pacemaker cell of sinuatrial node" EXACT [] xref: FMA:83383 is_a: CL:1000409 ! myocyte of sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node namespace: cell def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002351 ! sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000479 name: purkinje myocyte of atrioventricular node namespace: cell def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] xref: FMA:83386 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002352 ! atrioventricular node relationship: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000480 name: transitional myocyte of internodal tract namespace: cell def: "A transitional myocyte that is part of the internodal tract." [GOC:tfm] xref: FMA:83387 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:0002096 ! internodal tract myocyte intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract [Term] id: CL:1000481 name: transitional myocyte of atrioventricular bundle namespace: cell def: "A transitional myocyte that is part of the atrioventricular bundle." [GOC:tfm] xref: FMA:83388 xref: FMA:83885 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:0010005 ! atrioventricular bundle cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002353 ! atrioventricular bundle relationship: part_of UBERON:0002353 ! atrioventricular bundle [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum namespace: cell def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] xref: FMA:83390 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum native cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000483 name: purkinje myocyte of internodal tract namespace: cell def: "A Purkinje myocyte that is part of the internodal tract." [GOC:tfm] xref: FMA:83392 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:0002096 ! internodal tract myocyte intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract [Term] id: CL:1000484 name: purkinje myocyte of atrioventricular bundle namespace: cell def: "A Purkinje myocyte that is part of the atrioventricular bundle." [GOC:tfm] xref: FMA:83393 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:0010005 ! atrioventricular bundle cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002353 ! atrioventricular bundle relationship: part_of UBERON:0002353 ! atrioventricular bundle [Term] id: CL:1000486 name: basal cell of urothelium namespace: cell def: "A basal cell that is part of the urothelium." [GOC:tfm] xref: FMA:84150 is_a: CL:0000646 {is_inferred="true"} ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0000365 ! urothelium relationship: part_of UBERON:0000365 ! urothelium [Term] id: CL:1000487 name: smooth muscle cell of prostate namespace: cell def: "A smooth muscle cell that is part of the prostate gland." [GOC:tfm] synonym: "smooth muscle fiber of prostate" EXACT [FMA:84583] xref: FMA:84583 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland [Term] id: CL:1000488 name: cholangiocyte namespace: cell def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] synonym: "epithelial cell of bile duct" EXACT [] xref: FMA:86481 is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0002394 ! bile duct relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002394 ! bile duct [Term] id: CL:1000489 name: reticular cell of splenic cord namespace: cell def: "A reticular cell that is part of the splenic cord." [GOC:tfm] xref: FMA:86497 is_a: CL:0000432 {is_inferred="true"} ! reticular cell intersection_of: CL:0000432 ! reticular cell intersection_of: part_of UBERON:0001266 ! splenic cord relationship: part_of UBERON:0001266 ! splenic cord [Term] id: CL:1000490 name: mesothelial cell of peritoneum namespace: cell def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] synonym: "peritoneal mesothelial cell" EXACT [FMA:86736] xref: FMA:86736 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002358 ! peritoneum relationship: part_of UBERON:0002358 ! peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura namespace: cell def: "A mesothelial cell that is part of the pleura." [GOC:tfm] synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura namespace: cell def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002400 ! parietal pleura relationship: part_of UBERON:0002400 ! parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura namespace: cell def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] xref: FMA:86739 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002401 ! visceral pleura relationship: part_of UBERON:0002401 ! visceral pleura [Term] id: CL:1000494 name: nephron tubule epithelial cell namespace: cell def: "An epithelial cell that is part of a nephron tubule." [GOC:tfm] comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON. synonym: "kidney tubule epithelial cell" EXACT [] xref: FMA:86785 xref: KUPO:0001022 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004810 ! nephron tubule epithelium relationship: part_of UBERON:0004810 ! nephron tubule epithelium [Term] id: CL:1000495 name: small intestine goblet cell namespace: cell def: "A goblet cell that is part of the small intestine." [GOC:tfm] synonym: "goblet cell of epithelium of small intestine" EXACT [] synonym: "goblet cell of small intestine" EXACT [] synonym: "small intestinal goblet cell" EXACT [FMA:86929] xref: FMA:86929 is_a: CL:0000160 ! goblet cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000497 name: kidney cell namespace: cell xref: KUPO:0001010 is_a: CL:0000548 {is_inferred="true"} ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1000500 name: kidney interstitial cell namespace: cell xref: KUPO:0001013 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005215 ! kidney interstitium relationship: part_of UBERON:0005215 ! kidney interstitium [Term] id: CL:1000504 name: kidney medulla cell namespace: cell xref: KUPO:0001017 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla [Term] id: CL:1000505 name: kidney pelvis cell namespace: cell xref: KUPO:0001018 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis [Term] id: CL:1000507 name: kidney tubule cell namespace: cell xref: KUPO:0001020 is_a: CL:0002518 ! kidney epithelial cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0001231 ! nephron tubule [Term] id: CL:1000510 name: kidney glomerular epithelial cell namespace: cell xref: KUPO:0001023 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0004188 ! glomerular epithelium relationship: part_of UBERON:0004188 ! glomerular epithelium [Term] id: CL:1000546 name: kidney medulla collecting duct epithelial cell namespace: cell xref: KUPO:0001060 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005185 ! renal medulla collecting duct relationship: part_of UBERON:0005185 ! renal medulla collecting duct [Term] id: CL:1000547 name: kidney inner medulla collecting duct epithelial cell namespace: cell xref: KUPO:0001061 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005187 relationship: part_of UBERON:0005187 [Term] id: CL:1000548 name: kidney outer medulla collecting duct epithelial cell namespace: cell xref: KUPO:0001062 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005186 relationship: part_of UBERON:0005186 [Term] id: CL:1000549 name: kidney cortex collecting duct epithelial cell namespace: cell xref: KUPO:0001063 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005267 relationship: part_of UBERON:0005267 [Term] id: CL:1000550 name: kidney papillary duct principal epithelial cell namespace: cell xref: KUPO:0001064 is_a: CL:1001225 ! kidney collecting duct cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005167 ! papillary duct relationship: part_of UBERON:0005167 ! papillary duct [Term] id: CL:1000596 name: inner renal cortex cell namespace: cell xref: KUPO:0001111 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0005271 ! juxtamedullary cortex relationship: part_of UBERON:0005271 ! juxtamedullary cortex [Term] id: CL:1000597 name: papillary tips cell namespace: cell xref: KUPO:0001112 is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0009095 ! tip of renal papilla relationship: part_of UBERON:0009095 ! tip of renal papilla [Term] id: CL:1000600 name: lower urinary tract cell namespace: cell xref: KUPO:0001115 is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001556 ! lower urinary tract relationship: part_of UBERON:0001556 ! lower urinary tract [Term] id: CL:1000601 name: ureteral cell namespace: cell xref: KUPO:0001116 is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter [Term] id: CL:1000606 name: kidney nerve cell namespace: cell xref: KUPO:0001015 is_a: CL:0000540 ! neuron is_a: CL:1000500 ! kidney interstitial cell intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1000612 name: kidney corpuscule cell namespace: cell xref: KUPO:0001021 is_a: CL:0002584 {is_inferred="true"} ! renal cortical epithelial cell intersection_of: CL:0002584 ! renal cortical epithelial cell intersection_of: part_of UBERON:0001229 ! renal corpuscle relationship: part_of UBERON:0001229 ! renal corpuscle [Term] id: CL:1000615 name: kidney cortex tubule cell namespace: cell xref: KUPO:0001024 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell is_a: CL:1000507 {is_inferred="true"} ! kidney tubule cell intersection_of: CL:1000507 ! kidney tubule cell intersection_of: part_of UBERON:0006853 ! renal cortex tubule relationship: part_of UBERON:0006853 ! renal cortex tubule [Term] id: CL:1000616 name: kidney outer medulla cell namespace: cell xref: KUPO:0001025 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney [Term] id: CL:1000617 name: kidney inner medulla cell namespace: cell xref: KUPO:0001026 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: CL:1000618 name: juxtaglomerular complex cell namespace: cell synonym: "juxtaglomerulus cell" EXACT [GO:0072052] xref: KUPO:0001028 is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell intersection_of: CL:0002681 ! kidney cortical cell intersection_of: part_of UBERON:0002303 ! juxtaglomerular apparatus relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus [Term] id: CL:1000681 name: kidney cortex interstitial cell namespace: cell xref: KUPO:0001091 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell intersection_of: CL:1000500 ! kidney interstitial cell intersection_of: part_of UBERON:0005270 ! renal cortex interstitium relationship: part_of UBERON:0005270 ! renal cortex interstitium [Term] id: CL:1000682 name: kidney medulla interstitial cell namespace: cell xref: KUPO:0001092 is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000500 ! kidney interstitial cell intersection_of: part_of UBERON:0005211 ! renal medulla interstitium relationship: part_of UBERON:0005211 ! renal medulla interstitium [Term] id: CL:1000691 name: kidney interstitial myofibroblast namespace: cell xref: KUPO:0001101 is_a: CL:0000186 ! myofibroblast cell is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000692 name: kidney interstitial fibroblast namespace: cell xref: KUPO:0001102 is_a: CL:0000057 ! fibroblast is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000693 name: kidney interstitial fibrocyte namespace: cell xref: KUPO:0001103 is_a: CL:0000135 ! fibrocyte is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000695 name: kidney interstitial alternatively activated macrophage namespace: cell xref: KUPO:0001106 is_a: CL:0000890 ! alternatively activated macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000696 name: kidney interstitial inflammatory macrophage namespace: cell xref: KUPO:0001107 is_a: CL:0000863 ! inflammatory macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000697 name: kidney interstitial suppressor macrophage namespace: cell xref: KUPO:0001108 is_a: CL:0000862 ! suppressor macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000698 name: kidney resident macrophage namespace: cell xref: KUPO:0001109 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000699 name: kidney resident dendritic cell namespace: cell xref: KUPO:0001110 is_a: CL:0001007 ! interstitial dendritic cell is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000702 name: kidney pelvis smooth muscle cell namespace: cell xref: KUPO:0001113 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004227 ! kidney pelvis smooth muscle relationship: part_of UBERON:0004227 ! kidney pelvis smooth muscle [Term] id: CL:1000703 name: kidney pelvis urothelial cell namespace: cell xref: KUPO:0001114 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell is_a: CL:1000706 ! ureter urothelial cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: part_of UBERON:0004788 ! kidney pelvis urothelium relationship: part_of UBERON:0004788 ! kidney pelvis urothelium [Term] id: CL:1000706 name: ureter urothelial cell namespace: cell xref: KUPO:0001117 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1000601 {is_inferred="true"} ! ureteral cell intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0001254 ! urothelium of ureter relationship: part_of UBERON:0001254 ! urothelium of ureter [Term] id: CL:1000708 name: ureter adventitial cell namespace: cell xref: KUPO:0001119 is_a: CL:0000115 ! endothelial cell is_a: CL:0002503 ! adventitial cell is_a: CL:1000601 {is_inferred="true"} ! ureteral cell intersection_of: CL:1000601 ! ureteral cell intersection_of: part_of UBERON:0001252 ! adventitia of ureter relationship: part_of UBERON:0001252 ! adventitia of ureter [Term] id: CL:1000714 name: kidney cortex collecting duct principal cell namespace: cell xref: KUPO:0001130 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005267 relationship: part_of UBERON:0005267 [Term] id: CL:1000715 name: kidney cortex collecting duct intercalated cell namespace: cell xref: KUPO:0001131 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005267 relationship: part_of UBERON:0005267 [Term] id: CL:1000716 name: kidney outer medulla collecting duct principal cell namespace: cell xref: KUPO:0001132 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005186 relationship: part_of UBERON:0005186 [Term] id: CL:1000717 name: kidney outer medulla collecting duct intercalated cell namespace: cell xref: KUPO:0001133 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005186 relationship: part_of UBERON:0005186 [Term] id: CL:1000718 name: kidney inner medulla collecting duct principal cell namespace: cell xref: KUPO:0001134 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005187 relationship: part_of UBERON:0005187 [Term] id: CL:1000719 name: kidney inner medulla collecting duct intercalated cell namespace: cell xref: KUPO:0001135 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005187 relationship: part_of UBERON:0005187 [Term] id: CL:1000720 name: kidney papillary duct intercalated cell namespace: cell xref: KUPO:0001136 is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0005167 ! papillary duct relationship: part_of UBERON:0005167 ! papillary duct [Term] id: CL:1000721 name: kidney papillary duct principal cell namespace: cell xref: KUPO:0001137 is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0005167 ! papillary duct relationship: part_of UBERON:0005167 ! papillary duct [Term] id: CL:1000742 name: glomerular mesangial cell namespace: cell def: "Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney." [Wikipedia:Intraglomerular_mesangial_cell] synonym: "intraglomerular mesangial cell" EXACT [CL:cjm] xref: KUPO:0001032 is_a: CL:0000650 ! mesangial cell is_a: CL:1000612 {is_inferred="true"} ! kidney corpuscule cell is_a: CL:1001318 ! renal interstitial pericyte intersection_of: CL:1000612 ! kidney corpuscule cell intersection_of: part_of UBERON:0002320 ! glomerular mesangium relationship: part_of UBERON:0002320 ! glomerular mesangium [Term] id: CL:1000746 name: glomerular cell namespace: cell xref: KUPO:0001036 is_a: CL:1000612 {is_inferred="true"} ! kidney corpuscule cell intersection_of: CL:1000612 ! kidney corpuscule cell intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus [Term] id: CL:1000768 name: kidney connecting tubule epithelial cell namespace: cell xref: KUPO:0001058 is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: part_of UBERON:0005097 ! renal connecting tubule relationship: part_of UBERON:0005097 ! renal connecting tubule [Term] id: CL:1000803 name: kidney inner medulla interstitial cell namespace: cell xref: KUPO:0001093 is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell intersection_of: CL:1000682 ! kidney medulla interstitial cell intersection_of: part_of UBERON:0005214 ! inner renal medulla interstitium relationship: part_of UBERON:0005214 ! inner renal medulla interstitium [Term] id: CL:1000804 name: kidney outer medulla interstitial cell namespace: cell xref: KUPO:0001094 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell intersection_of: CL:1000682 ! kidney medulla interstitial cell intersection_of: part_of UBERON:0005213 ! outer renal medulla interstitium relationship: part_of UBERON:0005213 ! outer renal medulla interstitium [Term] id: CL:1000838 name: kidney proximal convoluted tubule epithelial cell namespace: cell xref: KUPO:0001045 is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule is_a: CL:1000615 {is_inferred="true"} ! kidney cortex tubule cell intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: part_of UBERON:0001287 ! proximal convoluted tubule relationship: part_of UBERON:0001287 ! proximal convoluted tubule [Term] id: CL:1000839 name: kidney proximal straight tubule epithelial cell namespace: cell xref: KUPO:0001046 is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule is_a: CL:1000615 {is_inferred="true"} ! kidney cortex tubule cell is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: part_of UBERON:0001290 ! proximal straight tubule relationship: part_of UBERON:0001290 ! proximal straight tubule [Term] id: CL:1000849 name: kidney distal convoluted tubule epithelial cell namespace: cell xref: KUPO:0001056 is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: part_of UBERON:0001292 ! distal convoluted tubule relationship: part_of UBERON:0001292 ! distal convoluted tubule [Term] id: CL:1000850 name: macula densa epithelial cell namespace: cell xref: KUPO:0001057 is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: part_of UBERON:0002335 ! macula densa relationship: part_of UBERON:0002335 ! macula densa [Term] id: CL:1000854 name: kidney blood vessel cell namespace: cell xref: KUPO:0001014 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: part_of UBERON:0003517 ! kidney blood vessel relationship: part_of UBERON:0003517 ! kidney blood vessel relationship: participates_in GO:0008015 ! blood circulation [Term] id: CL:1000891 name: kidney arterial blood vessel cell namespace: cell xref: KUPO:0001029 is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: part_of UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0003644 ! kidney arterial blood vessel [Term] id: CL:1000892 name: kidney capillary endothelial cell namespace: cell xref: KUPO:0001030 is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:1000854 ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: part_of UBERON:0003527 ! kidney capillary relationship: part_of UBERON:0003527 ! kidney capillary [Term] id: CL:1000893 name: kidney venous blood vessel cell namespace: cell xref: KUPO:0001031 is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: part_of UBERON:0001140 ! renal vein relationship: part_of UBERON:0001140 ! renal vein [Term] id: CL:1000909 name: kidney loop of henle epithelial cell namespace: cell xref: KUPO:0001047 is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: part_of UBERON:0001288 ! loop of Henle relationship: part_of UBERON:0001288 ! loop of Henle [Term] id: CL:1000979 name: ureter smooth muscle cell namespace: cell xref: KUPO:0001118 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1000601 {is_inferred="true"} ! ureteral cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0006855 ! muscular coat of ureter relationship: part_of UBERON:0006855 ! muscular coat of ureter [Term] id: CL:1001005 name: glomerular capillary endothelial cell namespace: cell xref: KUPO:0001037 is_a: CL:0002144 ! capillary endothelial cell is_a: CL:0002188 ! glomerular endothelial cell is_a: CL:1000510 ! kidney glomerular epithelial cell is_a: CL:1000746 {is_inferred="true"} ! glomerular cell is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: part_of UBERON:0004294 ! glomerular capillary endothelium relationship: part_of UBERON:0004294 ! glomerular capillary endothelium [Term] id: CL:1001006 name: kidney afferent arteriole cell namespace: cell xref: KUPO:0001038 is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: part_of UBERON:0004639 ! renal afferent arteriole relationship: part_of UBERON:0004639 ! renal afferent arteriole [Term] id: CL:1001009 name: kidney efferent arteriole cell namespace: cell xref: KUPO:0001041 is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: part_of UBERON:0004640 ! renal efferent arteriole relationship: part_of UBERON:0004640 ! renal efferent arteriole [Term] id: CL:1001016 name: kidney loop of henle ascending limb epithelial cell namespace: cell xref: KUPO:0001048 is_a: CL:0002305 ! epithelial cell of distal tubule is_a: CL:1000909 {is_inferred="true"} ! kidney loop of henle epithelial cell intersection_of: CL:1000909 ! kidney loop of henle epithelial cell intersection_of: part_of UBERON:0005164 ! ascending limb of loop of Henle relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle [Term] id: CL:1001021 name: kidney loop of henle descending limb epithelial cell namespace: cell xref: KUPO:0001053 is_a: CL:1000909 {is_inferred="true"} ! kidney loop of henle epithelial cell intersection_of: CL:1000909 ! kidney loop of henle epithelial cell intersection_of: part_of UBERON:0001289 ! descending limb of loop of Henle relationship: part_of UBERON:0001289 ! descending limb of loop of Henle [Term] id: CL:1001033 name: peritubular capillary endothelial cell namespace: cell xref: KUPO:0001065 is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: part_of UBERON:0005272 ! peritubular capillary relationship: part_of UBERON:0005272 ! peritubular capillary [Term] id: CL:1001036 name: vasa recta cell namespace: cell xref: KUPO:0001068 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell is_a: CL:1000893 ! kidney venous blood vessel cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: part_of UBERON:0004726 ! vasa recta relationship: part_of UBERON:0004726 ! vasa recta [Term] id: CL:1001045 name: kidney cortex artery cell namespace: cell xref: KUPO:0001077 is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: part_of UBERON:0005268 ! renal cortex artery relationship: part_of UBERON:0005268 ! renal cortex artery [Term] id: CL:1001052 name: kidney cortex vein cell namespace: cell xref: KUPO:0001084 is_a: CL:1000893 {is_inferred="true"} ! kidney venous blood vessel cell intersection_of: CL:1000893 ! kidney venous blood vessel cell intersection_of: part_of UBERON:0005269 ! renal cortex vein relationship: part_of UBERON:0005269 ! renal cortex vein [Term] id: CL:1001064 name: kidney artery smooth muscle cell namespace: cell comment: Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure. xref: KUPO:0001096 is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000891 ! kidney arterial blood vessel cell [Term] id: CL:1001066 name: kidney arteriole smooth muscle cell namespace: cell comment: Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure. xref: KUPO:0001098 is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000891 ! kidney arterial blood vessel cell [Term] id: CL:1001068 name: kidney venous system smooth muscle cell namespace: cell comment: Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure. xref: KUPO:0001100 is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000893 ! kidney venous blood vessel cell [Term] id: CL:1001096 name: kidney afferent arteriole endothelial cell namespace: cell xref: KUPO:0001039 is_a: CL:1000412 {is_inferred="true"} ! endothelial cell of arteriole is_a: CL:1001006 ! kidney afferent arteriole cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004639 ! renal afferent arteriole relationship: part_of UBERON:0004639 ! renal afferent arteriole [Term] id: CL:1001097 name: kidney afferent arteriole smooth muscle cell namespace: cell xref: KUPO:0001040 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:1001006 ! kidney afferent arteriole cell is_a: CL:1001066 ! kidney arteriole smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004639 ! renal afferent arteriole relationship: part_of UBERON:0004639 ! renal afferent arteriole [Term] id: CL:1001099 name: kidney efferent arteriole endothelial cell namespace: cell xref: KUPO:0001042 is_a: CL:1000412 {is_inferred="true"} ! endothelial cell of arteriole is_a: CL:1001009 ! kidney efferent arteriole cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004640 ! renal efferent arteriole relationship: part_of UBERON:0004640 ! renal efferent arteriole [Term] id: CL:1001100 name: kidney efferent arteriole smooth muscle cell namespace: cell xref: KUPO:0001043 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:1001009 ! kidney efferent arteriole cell is_a: CL:1001066 ! kidney arteriole smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004640 ! renal efferent arteriole relationship: part_of UBERON:0004640 ! renal efferent arteriole [Term] id: CL:1001106 name: kidney loop of henle thick ascending limb epithelial cell namespace: cell xref: KUPO:0001049 is_a: CL:1000504 ! kidney medulla cell is_a: CL:1001016 {is_inferred="true"} ! kidney loop of henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0001291 ! thick ascending limb of loop of Henle relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle [Term] id: CL:1001107 name: kidney loop of henle thin ascending limb epithelial cell namespace: cell xref: KUPO:0001050 is_a: CL:1001016 {is_inferred="true"} ! kidney loop of henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment relationship: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment [Term] id: CL:1001108 name: kidney loop of henle medullary thick ascending limb epithelial cell namespace: cell xref: KUPO:0001051 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001016 {is_inferred="true"} ! kidney loop of henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0006376 ! premacula segment of distal straight tubule relationship: part_of UBERON:0006376 ! premacula segment of distal straight tubule [Term] id: CL:1001109 name: kidney loop of henle cortical thick ascending limb epithelial cell namespace: cell xref: KUPO:0001052 is_a: CL:1001016 {is_inferred="true"} ! kidney loop of henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of henle ascending limb epithelial cell intersection_of: part_of UBERON:0006854 ! distal straight tubule postmacula segment relationship: part_of UBERON:0006854 ! distal straight tubule postmacula segment [Term] id: CL:1001111 name: kidney loop of henle thin descending limb epithelial cell namespace: cell xref: KUPO:0001054 is_a: CL:1000507 ! kidney tubule cell is_a: CL:1000616 ! kidney outer medulla cell is_a: CL:1001021 {is_inferred="true"} ! kidney loop of henle descending limb epithelial cell intersection_of: CL:1001021 ! kidney loop of henle descending limb epithelial cell intersection_of: part_of UBERON:0005096 ! descending thin limb relationship: part_of UBERON:0005096 ! descending thin limb [Term] id: CL:1001123 name: kidney outer medulla peritubular capillary cell namespace: cell xref: KUPO:0001066 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001033 {is_inferred="true"} ! peritubular capillary endothelial cell intersection_of: CL:1001033 ! peritubular capillary endothelial cell intersection_of: part_of UBERON:0006341 ! outer renal medulla peritubular capillary relationship: part_of UBERON:0006341 ! outer renal medulla peritubular capillary [Term] id: CL:1001124 name: kidney cortex peritubular capillary cell namespace: cell xref: KUPO:0001067 is_a: CL:1001033 {is_inferred="true"} ! peritubular capillary endothelial cell intersection_of: CL:1001033 ! peritubular capillary endothelial cell intersection_of: part_of UBERON:0006851 ! renal cortex peritubular capillary relationship: part_of UBERON:0006851 ! renal cortex peritubular capillary [Term] id: CL:1001126 name: inner renal medulla vasa recta cell namespace: cell xref: KUPO:0001069 is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0004776 ! inner renal medulla vasa recta relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta [Term] id: CL:1001127 name: outer renal medulla vasa recta cell namespace: cell xref: KUPO:0001070 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0004775 ! outer renal medulla vasa recta relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta [Term] id: CL:1001131 name: vasa recta ascending limb cell namespace: cell xref: KUPO:0001074 is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0009091 ! vasa recta ascending limb relationship: part_of UBERON:0009091 ! vasa recta ascending limb [Term] id: CL:1001135 name: arcuate artery cell namespace: cell xref: KUPO:0001078 is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell intersection_of: CL:1001045 ! kidney cortex artery cell intersection_of: part_of UBERON:0001552 ! kidney arcuate artery relationship: part_of UBERON:0001552 ! kidney arcuate artery [Term] id: CL:1001138 name: interlobular artery cell namespace: cell xref: KUPO:0001081 is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell intersection_of: CL:1001045 ! kidney cortex artery cell intersection_of: part_of UBERON:0004723 ! interlobular artery relationship: part_of UBERON:0004723 ! interlobular artery [Term] id: CL:1001142 name: arcuate vein cell namespace: cell xref: KUPO:0001085 is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell intersection_of: CL:1001052 ! kidney cortex vein cell intersection_of: part_of UBERON:0004719 ! kidney arcuate vein relationship: part_of UBERON:0004719 ! kidney arcuate vein [Term] id: CL:1001145 name: interlobular vein cell namespace: cell xref: KUPO:0001088 is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell intersection_of: CL:1001052 ! kidney cortex vein cell intersection_of: part_of UBERON:0005168 ! renal interlobular vein relationship: part_of UBERON:0005168 ! renal interlobular vein [Term] id: CL:1001209 name: inner medulla vasa recta ascending limb cell namespace: cell xref: KUPO:0001075 is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell intersection_of: CL:1001131 ! vasa recta ascending limb cell intersection_of: part_of UBERON:0009092 ! inner medulla vasa recta ascending limb relationship: part_of UBERON:0009092 ! inner medulla vasa recta ascending limb [Term] id: CL:1001210 name: outer medulla vasa recta ascending limb cell namespace: cell xref: KUPO:0001076 is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell intersection_of: CL:1001131 ! vasa recta ascending limb cell intersection_of: part_of UBERON:0009093 ! outer medulla vasa recta ascending limb relationship: part_of UBERON:0009093 ! outer medulla vasa recta ascending limb [Term] id: CL:1001213 name: arcuate artery endothelial cell namespace: cell xref: KUPO:0001079 is_a: CL:1000413 {is_inferred="true"} ! endothelial cell of artery is_a: CL:1001135 ! arcuate artery cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001552 ! kidney arcuate artery relationship: part_of UBERON:0001552 ! kidney arcuate artery [Term] id: CL:1001214 name: arcuate artery smooth muscle cell namespace: cell xref: KUPO:0001080 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:1001064 ! kidney artery smooth muscle cell is_a: CL:1001135 ! arcuate artery cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001552 ! kidney arcuate artery relationship: part_of UBERON:0001552 ! kidney arcuate artery [Term] id: CL:1001216 name: interlobulary artery endothelial cell namespace: cell xref: KUPO:0001082 is_a: CL:1000413 ! endothelial cell of artery is_a: CL:1001138 ! interlobular artery cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004723 ! interlobular artery relationship: part_of UBERON:0004723 ! interlobular artery [Term] id: CL:1001217 name: interlobulary artery smooth muscle cell namespace: cell xref: KUPO:0001083 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:1001064 ! kidney artery smooth muscle cell is_a: CL:1001138 ! interlobular artery cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004723 ! interlobular artery relationship: part_of UBERON:0004723 ! interlobular artery [Term] id: CL:1001220 name: arcuate vein endothelial cell namespace: cell xref: KUPO:0001086 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1001142 ! arcuate vein cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0004719 ! kidney arcuate vein relationship: part_of UBERON:0004719 ! kidney arcuate vein [Term] id: CL:1001221 name: arcuate vein smooth muscle cell namespace: cell xref: KUPO:0001087 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:1001068 ! kidney venous system smooth muscle cell is_a: CL:1001142 ! arcuate vein cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004719 ! kidney arcuate vein relationship: part_of UBERON:0004719 ! kidney arcuate vein [Term] id: CL:1001223 name: interlobulary vein endothelial cell namespace: cell xref: KUPO:0001089 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1001145 ! interlobular vein cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0005168 ! renal interlobular vein relationship: part_of UBERON:0005168 ! renal interlobular vein [Term] id: CL:1001224 name: interlobulary vein smooth muscle cell namespace: cell xref: KUPO:0001090 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:1001068 ! kidney venous system smooth muscle cell is_a: CL:1001145 ! interlobular vein cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0005168 ! renal interlobular vein relationship: part_of UBERON:0005168 ! renal interlobular vein [Term] id: CL:1001225 name: kidney collecting duct cell namespace: cell xref: KUPO:0001012 xref: Wikipedia:Kidney_collecting_duct_cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001285 name: vasa recta descending limb cell namespace: cell xref: KUPO:0001071 is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: part_of UBERON:0009202 ! vasa recta descending limb relationship: part_of UBERON:0009202 ! vasa recta descending limb [Term] id: CL:1001286 name: inner medulla vasa recta descending limb cell namespace: cell xref: KUPO:0001072 is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell intersection_of: CL:1001285 ! vasa recta descending limb cell intersection_of: part_of UBERON:0009089 ! inner medulla vasa recta descending limb relationship: part_of UBERON:0009089 ! inner medulla vasa recta descending limb [Term] id: CL:1001287 name: outer medulla vasa recta descending limb cell namespace: cell xref: KUPO:0001073 is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell intersection_of: CL:1001285 ! vasa recta descending limb cell intersection_of: part_of UBERON:0009090 ! outer medulla vasa recta descending limb relationship: part_of UBERON:0009090 ! outer medulla vasa recta descending limb [Term] id: CL:1001318 name: renal interstitial pericyte namespace: cell xref: KUPO:0001104 is_a: CL:0000669 {is_inferred="true"} ! pericyte cell is_a: CL:1000497 ! kidney cell intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1001319 name: bladder cell namespace: cell xref: KUPO:0001120 is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder [Term] id: CL:1001320 name: urethra cell namespace: cell xref: KUPO:0001123 is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 ! urethra [Term] id: CL:1001428 name: bladder urothelial cell namespace: cell xref: KUPO:0001121 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1001319 {is_inferred="true"} ! bladder cell intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0004645 ! urinary bladder urothelium relationship: part_of UBERON:0004645 ! urinary bladder urothelium [Term] id: CL:1001430 name: urethra urothelial cell namespace: cell xref: KUPO:0001124 is_a: CL:0000731 {is_inferred="true"} ! urothelial cell is_a: CL:1000296 ! epithelial cell of urethra intersection_of: CL:0000731 ! urothelial cell intersection_of: part_of UBERON:0004787 ! urethra urothelium relationship: part_of UBERON:0004787 ! urethra urothelium [Term] id: CL:1001431 name: kidney collecting duct principal cell namespace: cell xref: KUPO:0001128 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001432 name: kidney collecting duct intercalated cell namespace: cell xref: http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells xref: KUPO:0001129 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001433 name: epithelial cell of exocrine pancreas namespace: cell def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: CL:1001434 name: olfactory bulb interneuron namespace: cl def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310] is_a: CL:0000099 ! interneuron is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0002264 ! olfactory bulb [Term] id: CL:1001435 name: periglomerular cell namespace: cl def: "the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [MP:0009943] synonym: "glomerular layer cell" EXACT [NIFSTD:nifext_122] synonym: "olfactory bulb (accessory) glomerular layer cell" EXACT [NIFSTD:nifext_122] synonym: "olfactory bulb glomerular layer cell" EXACT [NIFSTD:nifext_122] synonym: "olfactory bulb glomerularal cell" EXACT [MP:0009943] synonym: "periglomerular cell" EXACT [NIFSTD:nifext_122] xref: BTO:0003796 xref: NIFSTD:nifext_122 is_a: CL:1001434 ! olfactory bulb interneuron relationship: part_of UBERON:0005377 ! olfactory bulb glomerular layer [Term] id: CL:1001436 name: hair-tylotrich neuron namespace: cl def: "the subcutaneous mechanoreceptors that innervate tylotrich hair follicles" [MP:0000977] is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001437 name: hair-down neuron namespace: cl def: "the subcutaneous mechanoreceptors that innervate vellus hairs" [MP:0000979] is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001451 name: sensory neuron of dorsal root ganglion namespace: cl def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297] synonym: "proprioceptive neuron" EXACT [MP:0004297] is_a: CL:0000101 {is_inferred="true"} ! sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: part_of UBERON:0000044 ! dorsal root ganglion relationship: part_of UBERON:0000044 ! dorsal root ganglion [Term] id: CL:1001474 name: medium spiny neuron namespace: cl def: "the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [MP:0008462] synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778] synonym: "striatal medium spiny neuron" EXACT [GO:0021773] xref: BTO:0004778 is_a: CL:0000540 ! neuron relationship: part_of UBERON:0000369 ! corpus striatum [Term] id: CL:1001502 name: mitral cell namespace: cl def: "the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [MP:0009954] is_a: CL:1001434 ! olfactory bulb interneuron relationship: part_of UBERON:0004186 ! olfactory bulb mitral cell layer [Term] id: CL:1001503 name: olfactory bulb tufted cell namespace: cl def: "the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala" [MP:0009955] is_a: CL:0000540 ! neuron relationship: part_of UBERON:0005376 ! olfactory bulb external plexiform layer [Term] id: CL:1001505 name: parvocellular neurosecretory cell namespace: cl def: "the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system" [MP:0010125] synonym: "parvocellular neuron" EXACT [] synonym: "parvocellular neurosecretory neuron" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000381 ! neurosecretory neuron relationship: capable_of GO:0030103 ! vasopressin secretion relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus [Term] id: CL:1001509 name: glycinergic neuron namespace: cl def: "the neurons that utilize glycine as a neurotransmitter" [MP:0010385] is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061537 ! glycine secretion, neurotransmission relationship: capable_of GO:0061537 ! glycine secretion, neurotransmission [Term] id: CL:1001516 name: intestinal enteroendocrine cell namespace: cl def: "the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MP:0010802] is_a: CL:0000164 ! enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001242 ! intestinal mucosa relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: CL:1001517 name: stomach enteroendocrine cell namespace: cl def: "the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MP:0010803] is_a: CL:0000164 ! enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach [Term] id: CL:1001561 name: vomeronasal sensory neuron namespace: cl def: "chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MP:0011679] is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: innervates UBERON:0003367 ! epithelium of vomeronasal organ intersection_of: part_of UBERON:0002255 ! vomeronasal organ relationship: innervates UBERON:0003367 ! epithelium of vomeronasal organ relationship: part_of UBERON:0002255 ! vomeronasal organ [Term] id: CL:1001566 name: bronchioalveolar stem cells namespace: cl def: "a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury." [MP:0011691] is_a: CL:0000034 ! stem cell relationship: part_of UBERON:0000115 ! lung epithelium [Term] id: CL:1001567 name: lung endothelial cell namespace: cl synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000102 ! lung vasculature relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1001568 name: pulmonary artery endothelial cell namespace: cl synonym: "PAEC cell" RELATED [BTO:0001141] xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0005317 ! pulmonary artery endothelium [Term] id: CL:1001569 name: hippocampal interneuron namespace: cl def: "An interneuron of the hippocampus." [GOC:pr] xref: FMA:84777 is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:1001571 name: hippocampal pyramidal neuron namespace: cl def: "A pyramidal neuron of the hippocampus." [GOC:pr, PMID:19342486] synonym: "hippocampus (CA) pyramidal cell" EXACT [NIFSTD:sao131261273] synonym: "hippocampus (CA) pyramidal neuron" EXACT [NIFSTD:sao131261273] xref: NIFSTD:sao131261273 xref: SAO:sao131261273 is_a: CL:0000598 ! pyramidal neuron is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0002313 ! hippocampus pyramidal layer [Term] id: CL:1001572 name: colon endothelial cell def: "Vascular endothelium found in colon blood vessels." [NPX:PDR] synonym: "colon endothelial cells" RELATED PLURAL [CALOHA:TS-2397] synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397] xref: CALOHA:TS-2397 is_a: CL:0000115 ! endothelial cell is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0013695 ! colon endothelium [Term] id: CL:1001573 name: nasopharyngeal epithelial cell def: "Cell of the nasopharyngeal epithelium." [NPX:PDR] synonym: "nasopharynx respiratory epithelial cells" RELATED [CALOHA:TS-2398] xref: CALOHA:TS-2398 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0001951 ! epithelium of nasopharynx [Term] id: CL:1001575 name: uterine cervix squamous cell def: "Squamous cell of uterine cervix epithelium." [NPX:PDR] synonym: "cervix squamous cell" RELATED [CALOHA:TS-1251] synonym: "cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] synonym: "cervix, uterine squamous epithelial cells" RELATED [CALOHA:TS-1251] synonym: "uterine cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] synonym: "uterine cervix squamous epithelial cells" RELATED [CALOHA:TS-1251] xref: CALOHA:TS-1251 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium [Term] id: CL:1001576 name: oral mucosa squamous cell def: "Squamous cell of oral epithelium." [NPX:PDR] synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252] synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252] xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: part_of UBERON:0002424 ! oral epithelium [Term] id: CL:1001577 name: tonsil squamous cell def: "Squamous cell of tonsil epithelium." [NPX:PDR] synonym: "tonsil squamous epithelial cell" RELATED [CALOHA:TS-1253] synonym: "tonsil squamous epithelial cells" RELATED [CALOHA:TS-1253] synonym: "tonsillar squamous cell" RELATED [CALOHA:TS-1253] synonym: "tonsillar squamous epithelial cell" RELATED [CALOHA:TS-1253] xref: CALOHA:TS-1253 is_a: CL:0000076 ! squamous epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0013696 ! tonsil epithelium [Term] id: CL:1001578 name: vagina squamous cell def: "Squamous cell of vaginal epithelium." [NPX:PDR] synonym: "vagina squamous epithelial cell" RELATED [CALOHA:TS-1254] synonym: "vagina squamous epithelial cells" RELATED [CALOHA:TS-1254] synonym: "vaginal squamous cell" RELATED [CALOHA:TS-1254] synonym: "vaginal squamous epithelial cell" RELATED [CALOHA:TS-1254] xref: CALOHA:TS-1254 is_a: CL:0000076 ! squamous epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina relationship: part_of UBERON:0001344 ! epithelium of vagina [Term] id: CL:1001579 name: cerebral cortex glial cell def: "Glial cell of cerebral cortex." [NPX:PDR] synonym: "brain cortex glial cell" RELATED [CALOHA:TS-1256] synonym: "cerebral cortex glial cells" RELATED [CALOHA:TS-1256] synonym: "cerebrum cortex glial cell" RELATED [CALOHA:TS-1256] xref: CALOHA:TS-1256 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:1001580 name: hippocampus glial cell def: "Glial cell of hippocampus." [NPX:PDR] synonym: "hippocampal glial cell" RELATED [CALOHA:TS-1257] synonym: "hippocampus glial cells" RELATED [CALOHA:TS-1257] synonym: "hippocampus neuroglial cell" RELATED [CALOHA:TS-1257] xref: CALOHA:TS-1257 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:1001581 name: lateral ventricle glial cell def: "Glial cell of lateral ventricle." [NPX:PDR] synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258] xref: CALOHA:TS-1258 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: CL:1001582 name: lateral ventricle neuron def: "Neuron of lateral ventricle." [NPX:PDR] synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261] xref: CALOHA:TS-1261 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] id: CL:1001583 name: obsolete breast adipocyte def: "OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma." [HPA:Breast] synonym: "breast adipocytes" RELATED [CALOHA:TS-2377] is_obsolete: true replaced_by: CL:0002617 [Term] id: CL:1001585 name: appendix glandular cell def: "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "appendix glandular cells" RELATED [CALOHA:TS-1271] synonym: "caecal appendix glandular cell" RELATED [CALOHA:TS-1271] synonym: "cecal appendix glandular cell" RELATED [CALOHA:TS-1271] synonym: "vermiform appendix glandular cell" RELATED [CALOHA:TS-1271] xref: CALOHA:TS-1271 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1000405 ! epithelial cell of appendix intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0001154 ! vermiform appendix relationship: part_of UBERON:0009697 ! epithelium of appendix [Term] id: CL:1001586 name: mammary gland glandular cell def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [NPX:PDR;HPA\:HPA] synonym: "breast glandular cell" RELATED [CALOHA:TS-1272] synonym: "breast glandular cells" RELATED [CALOHA:TS-1272] synonym: "mammary glandular cell" RELATED [CALOHA:TS-1272] xref: CALOHA:TS-1272 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0003244 ! epithelium of mammary gland [Term] id: CL:1001587 name: uterine cervix glandular cell def: "Glandular cell of uterine cervix epithelium." [NPX:PDR] synonym: "cervix glandular cell" RELATED [CALOHA:TS-1273] synonym: "cervix, uterine glandular cell" RELATED [CALOHA:TS-1273] synonym: "cervix, uterine glandular cells" RELATED [CALOHA:TS-1273] xref: CALOHA:TS-1273 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium [Term] id: CL:1001588 name: colon glandular cell def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "colon glandular cells" RELATED [CALOHA:TS-1274] xref: CALOHA:TS-1274 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0001155 ! colon [Term] id: CL:1001589 name: duodenum glandular cell def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] synonym: "duodenum glandular cells" RELATED [CALOHA:TS-1275] xref: CALOHA:TS-1275 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1001590 name: epididymis glandular cell def: "Glandular cell of epididymal epithelium." [NPX:PDR] synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276] synonym: "epididymis glandular cells" RELATED [CALOHA:TS-1276] xref: CALOHA:TS-1276 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0004544 ! epididymis epithelium [Term] id: CL:1001591 name: oviduct glandular cell def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [NPX:PDR;HPA\:HPA] synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277] synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277] synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277] xref: CALOHA:TS-1277 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0004804 ! oviduct epithelium [Term] id: CL:1001592 name: gall bladder glandular cell def: "Glandular cell of gall bladder epithelium." [NPX:PDR] synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cell" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278] xref: CALOHA:TS-1278 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1000415 ! epithelial cell of gall bladder intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002110 ! gall bladder relationship: part_of UBERON:0002029 ! epithelium of gall bladder relationship: part_of UBERON:0002110 ! gall bladder [Term] id: CL:1001593 name: parathyroid glandular cell def: "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." [NPX:PDR;HPA\:HPA] synonym: "parathyroid gland glandular cell" RELATED [CALOHA:TS-1279] synonym: "parathyroid gland glandular cells" RELATED [CALOHA:TS-1279] xref: CALOHA:TS-1279 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0011197 ! parathyroid epithelium [Term] id: CL:1001595 name: rectum glandular cell def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281] synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281] xref: CALOHA:TS-1281 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0003354 ! epithelium of rectum [Term] id: CL:1001596 name: salivary gland glandular cell def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [NPX:PDR;HPA\:HPA] synonym: "salivary gland glandular cells" RELATED [CALOHA:TS-1282] xref: CALOHA:TS-1282 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000152 ! exocrine cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001044 ! saliva-secreting gland relationship: part_of UBERON:0001044 ! saliva-secreting gland relationship: part_of UBERON:0004809 ! salivary gland epithelium [Term] id: CL:1001597 name: seminal vesicle glandular cell def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR] synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283] xref: CALOHA:TS-1283 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0004805 ! seminal vesicle epithelium [Term] id: CL:1001598 name: small intestine glandular cell def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell;NPX\:PDR] synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestinal glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286] xref: CALOHA:TS-1286 xref: FMA:86928 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1001599 name: pancreas exocrine glandular cell def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [NPX:PDR;HPA\:HPA] synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242] synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242] xref: BTO:0000028 xref: CALOHA:TS-1242 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium [Term] id: CL:1001601 name: adrenal gland glandular cell def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." [NPX:PDR] synonym: "adrenal gland glandular cells" RELATED [CALOHA:TS-2177] synonym: "adrenal glandular cell" RELATED [CALOHA:TS-2177] synonym: "suprarenal gland glandular cell" RELATED [CALOHA:TS-2177] xref: CALOHA:TS-2177 is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: CL:1001602 name: cerebral cortex endothelial cell def: "Endothelial cells forming the walls of the capillaries within the cerebral cortex." [NPX:PDR] synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372] synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372] xref: CALOHA:TS-2372 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0013694 ! brain endothelium [Term] id: CL:1001603 name: lung macrophage def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [NPX:PDR;HPA\:HPA] synonym: "lung macrophages" RELATED [CALOHA:TS-0576] xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1001606 name: foreskin keratinocyte def: "Keratinocyte from foreskin." [NPX:PDR] xref: CALOHA:TS-0385 is_a: CL:0000312 ! keratinocyte intersection_of: CL:0000312 ! keratinocyte intersection_of: part_of UBERON:0001332 ! prepuce of penis relationship: part_of UBERON:0001332 ! prepuce of penis [Term] id: CL:1001607 name: articular chondrocyte def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR] xref: CALOHA:TS-0056 is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: part_of UBERON:0010996 ! articular cartilage of joint relationship: part_of UBERON:0010996 ! articular cartilage of joint [Term] id: CL:1001608 name: foreskin fibroblast def: "Fibroblast from foreskin." [NPX:PDR] synonym: "BJ fibroblast" EXACT [] xref: CALOHA:TS-0384 is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0001332 ! prepuce of penis relationship: part_of UBERON:0001332 ! prepuce of penis [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [NPX:PDR] xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001630 ! muscle organ relationship: part_of UBERON:0001630 ! muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109] synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109] xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0012429 ! hemopoietic tissue [Term] id: CL:1001611 name: cerebellar neuron def: "Neuron of the cerebellum." [NPX:PDR] synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359] xref: CALOHA:TS-2359 xref: FMA:84665 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:2000000 name: epidermal melanocyte namespace: cell def: "Any melanocyte that is part of a epidermis." [GOC:TermGenie] comment: These cells are found primarily, but not exclusively, in primates including humans is_a: CL:0002484 ! epithelial melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis created_by: TermGenie creation_date: 2014-02-03T23:03:09Z [Term] id: CL:2000001 name: peripheral blood mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood created_by: TermGenie creation_date: 2014-02-11T17:29:04Z [Term] id: CL:2000002 name: decidua cell namespace: cell def: "Any native cell that is part of a decidua." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0002450 ! decidua relationship: part_of UBERON:0002450 ! decidua created_by: TermGenie creation_date: 2014-02-20T23:06:41Z [Term] id: CL:2000004 name: pituitary gland cell namespace: cell def: "Any cell that is part of a pituitary gland." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000007 ! pituitary gland relationship: part_of UBERON:0000007 ! pituitary gland created_by: TermGenie creation_date: 2014-03-26T22:14:56Z [Term] id: CL:2000005 name: brain macroglial cell namespace: cell def: "Any macroglial cell that is part of a brain." [GOC:TermGenie] is_a: CL:0000126 ! macroglial cell intersection_of: CL:0000126 ! macroglial cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain created_by: TermGenie creation_date: 2014-03-28T21:35:27Z [Term] id: CL:2000006 name: tonsil germinal center B cell namespace: cell def: "Any germinal center B cell that is part of a tonsil." [GOC:TermGenie] is_a: CL:0000844 ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: part_of UBERON:0002372 ! tonsil relationship: part_of UBERON:0002372 ! tonsil created_by: TermGenie creation_date: 2014-03-28T21:35:33Z [Term] id: CL:2000007 name: articular chondrocyte of knee joint namespace: cell def: "Chondrocyte forming the hyaline cartilage found in the knee joint." [GOC:TermGenie] is_a: CL:1001607 ! articular chondrocyte intersection_of: CL:1001607 ! articular chondrocyte intersection_of: part_of UBERON:0001485 ! knee joint relationship: part_of UBERON:0001485 ! knee joint created_by: TermGenie creation_date: 2014-06-04T14:40:11Z [Term] id: CL:2000008 name: microvascular endothelial cell namespace: cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium relationship: part_of UBERON:0008339 ! microvascular endothelium created_by: TermGenie creation_date: 2014-06-04T15:07:42Z [Term] id: CL:2000009 name: obsolete microvascular endothelium blood vessel endothelial cell namespace: cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_obsolete: true replaced_by: CL:2000008 created_by: TermGenie creation_date: 2014-06-04T15:09:18Z [Term] id: CL:2000010 name: dermis blood vessel endothelial cell namespace: cell def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: TermGenie creation_date: 2014-06-04T15:12:06Z [Term] id: CL:2000011 name: dermis lymphatic vessel endothelial cell namespace: cell def: "Any endothelial cell of lymphatic vessel that is part of a dermis." [GOC:TermGenie] is_a: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: TermGenie creation_date: 2014-06-04T15:15:08Z [Term] id: CL:2000012 name: fibroblast of pedal digit skin namespace: cell def: "Any skin fibroblast that is part of a pedal digit skin." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0003530 ! pedal digit skin relationship: part_of UBERON:0003530 ! pedal digit skin created_by: TermGenie creation_date: 2014-06-04T15:16:44Z [Term] id: CL:2000013 name: fibroblast of skin of abdomen namespace: cell def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0001416 ! skin of abdomen relationship: part_of UBERON:0001416 ! skin of abdomen created_by: TermGenie creation_date: 2014-06-04T15:18:16Z [Term] id: CL:2000014 name: fibroblast of upper leg skin namespace: cell def: "Any skin fibroblast that is part of a upper leg skin." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0004262 ! upper leg skin relationship: part_of UBERON:0004262 ! upper leg skin created_by: TermGenie creation_date: 2014-06-04T15:19:44Z [Term] id: CL:2000015 name: fibroblast of arm namespace: cell def: "Any skin fibroblast that is part of a arm." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0001460 ! arm relationship: part_of UBERON:0001460 ! arm created_by: TermGenie creation_date: 2014-06-04T15:29:06Z [Term] id: CL:2000016 name: lung microvascular endothelial cell namespace: cell def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:1001567 ! lung endothelial cell intersection_of: CL:1001567 ! lung endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium relationship: part_of UBERON:0008339 ! microvascular endothelium created_by: TermGenie creation_date: 2014-06-04T16:00:56Z [Term] id: CL:2000017 name: fibroblast of peridontal ligament namespace: cell def: "Any fibroblast that is part of a periodontal ligament." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0008266 ! periodontal ligament relationship: part_of UBERON:0008266 ! periodontal ligament created_by: TermGenie creation_date: 2014-06-04T16:50:33Z [Term] id: CL:2000018 name: endothelial cell of coronary artery namespace: cell def: "Any endothelial cell of artery that is part of a coronary artery." [GOC:TermGenie] is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:1000413 ! endothelial cell of artery intersection_of: part_of UBERON:0001621 ! coronary artery relationship: part_of UBERON:0001621 ! coronary artery created_by: TermGenie creation_date: 2014-06-04T17:08:47Z [Term] id: CL:2000019 name: compound eye photoreceptor cell namespace: cell def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000018 ! compound eye relationship: part_of UBERON:0000018 ! compound eye created_by: TermGenie creation_date: 2014-06-24T23:16:45Z [Term] id: CL:2000020 name: inner cell mass native cell namespace: cell def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000087 ! inner cell mass relationship: part_of UBERON:0000087 ! inner cell mass created_by: TermGenie creation_date: 2014-06-24T23:16:53Z [Term] id: CL:2000021 name: sebaceous gland native cell namespace: cell def: "Any native cell that is part of a sebaceous gland." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland created_by: TermGenie creation_date: 2014-06-24T23:17:00Z [Term] id: CL:2000022 name: cardiac septum native cell namespace: cell def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0002099 ! cardiac septum relationship: part_of UBERON:0002099 ! cardiac septum created_by: TermGenie creation_date: 2014-06-24T23:17:07Z [Term] id: CL:2000023 name: spinal cord ventral column interneuron namespace: cell def: "Any interneuron that is part of a spinal cord ventral column." [GOC:TermGenie] is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0005375 ! spinal cord ventral column relationship: part_of UBERON:0005375 ! spinal cord ventral column created_by: TermGenie creation_date: 2014-06-25T00:23:36Z [Term] id: CL:2000024 name: spinal cord medial motor column neuron namespace: cell def: "Any neuron that is part of a spinal cord medial motor column." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0004059 ! spinal cord medial motor column relationship: part_of UBERON:0004059 ! spinal cord medial motor column created_by: TermGenie creation_date: 2014-06-25T00:23:43Z [Term] id: CL:2000025 name: spinal cord oligodendrocyte namespace: cell def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie] is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000128 ! oligodendrocyte intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord created_by: TermGenie creation_date: 2014-06-25T00:23:50Z [Term] id: CL:2000026 name: obsolete cerebellum Golgi cell namespace: cell def: "Any Golgi cell that is part of a cerebellum." [GOC:TermGenie] is_obsolete: true created_by: TermGenie creation_date: 2014-06-25T00:23:57Z [Term] id: CL:2000027 name: cerebellum basket cell namespace: cell def: "Any basket cell that is part of a cerebellum." [GOC:TermGenie] is_a: CL:0000118 ! basket cell is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000118 ! basket cell intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum created_by: TermGenie creation_date: 2014-06-25T00:24:03Z [Term] id: CL:2000028 name: cerebellum glutamatergic neuron namespace: cell def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie] is_a: CL:0000679 ! glutamatergic neuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum created_by: TermGenie creation_date: 2014-06-25T00:24:10Z [Term] id: CL:2000029 name: central nervous system neuron namespace: cell def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system created_by: TermGenie creation_date: 2014-06-25T01:17:43Z [Term] id: CL:2000030 name: hypothalamus native cell namespace: cell def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0001898 ! hypothalamus relationship: part_of UBERON:0001898 ! hypothalamus created_by: TermGenie creation_date: 2014-06-25T01:17:50Z [Term] id: CL:2000031 name: lateral line ganglion neuron namespace: cell def: "Any neuron that is part of a lateral line ganglion." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:2000120 ! lateral line ganglion relationship: part_of UBERON:2000120 ! lateral line ganglion created_by: TermGenie creation_date: 2014-06-25T01:17:57Z [Term] id: CL:2000032 name: peripheral nervous system neuron namespace: cell def: "Any neuron that is part of a peripheral nervous system." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000010 ! peripheral nervous system created_by: TermGenie creation_date: 2014-06-25T02:28:17Z [Term] id: CL:2000033 name: limb basal cell of epidermis namespace: cell def: "Any basal cell of epidermis that is part of a limb." [GOC:TermGenie] is_a: CL:0002187 ! basal cell of epidermis intersection_of: CL:0002187 ! basal cell of epidermis intersection_of: part_of UBERON:0002101 ! limb relationship: part_of UBERON:0002101 ! limb created_by: TermGenie creation_date: 2014-06-25T02:28:25Z [Term] id: CL:2000034 name: anterior lateral line neuromast hair cell namespace: cell def: "Any neuromast hair cell that is part of a anterior lateral line." [GOC:TermGenie] is_a: CL:0000856 ! neuromast hair cell intersection_of: CL:0000856 ! neuromast hair cell intersection_of: part_of UBERON:2001470 ! anterior lateral line relationship: part_of UBERON:2001470 ! anterior lateral line created_by: TermGenie creation_date: 2014-06-25T03:44:37Z [Term] id: CL:2000035 name: anterior lateral line neuromast mantle cell namespace: cell def: "Any neuromast mantle cell that is part of a anterior lateral line." [GOC:TermGenie] is_a: CL:0000851 ! neuromast mantle cell intersection_of: CL:0000851 ! neuromast mantle cell intersection_of: part_of UBERON:2001470 ! anterior lateral line relationship: part_of UBERON:2001470 ! anterior lateral line created_by: TermGenie creation_date: 2014-06-25T03:44:44Z [Term] id: CL:2000036 name: anterior lateral line neuromast support cell namespace: cell def: "Any neuromast support cell that is part of a anterior lateral line." [GOC:TermGenie] is_a: CL:0000852 ! neuromast support cell intersection_of: CL:0000852 ! neuromast support cell intersection_of: part_of UBERON:2001470 ! anterior lateral line relationship: part_of UBERON:2001470 ! anterior lateral line created_by: TermGenie creation_date: 2014-06-25T03:44:51Z [Term] id: CL:2000037 name: posterior lateral line neuromast hair cell namespace: cell def: "Any neuromast hair cell that is part of a posterior lateral line." [GOC:TermGenie] is_a: CL:0000856 ! neuromast hair cell intersection_of: CL:0000856 ! neuromast hair cell intersection_of: part_of UBERON:0006334 ! posterior lateral line relationship: part_of UBERON:0006334 ! posterior lateral line created_by: TermGenie creation_date: 2014-06-25T03:44:57Z [Term] id: CL:2000038 name: posterior lateral line neuromast mantle cell namespace: cell def: "Any neuromast mantle cell that is part of a posterior lateral line." [GOC:TermGenie] is_a: CL:0000851 ! neuromast mantle cell intersection_of: CL:0000851 ! neuromast mantle cell intersection_of: part_of UBERON:0006334 ! posterior lateral line relationship: part_of UBERON:0006334 ! posterior lateral line created_by: TermGenie creation_date: 2014-06-25T03:45:04Z [Term] id: CL:2000039 name: posterior lateral line neuromast support cell namespace: cell def: "Any neuromast support cell that is part of a posterior lateral line." [GOC:TermGenie] is_a: CL:0000852 ! neuromast support cell intersection_of: CL:0000852 ! neuromast support cell intersection_of: part_of UBERON:0006334 ! posterior lateral line relationship: part_of UBERON:0006334 ! posterior lateral line created_by: TermGenie creation_date: 2014-06-25T03:45:11Z [Term] id: CL:2000040 name: bladder microvascular endothelial cell namespace: cell def: "Any microvascular endothelial cell that is part of a urinary bladder." [GOC:TermGenie] is_a: CL:1001319 ! bladder cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder created_by: TermGenie creation_date: 2014-07-09T00:04:47Z [Term] id: CL:2000041 name: dermis microvascular lymphatic vessel endothelial cell namespace: cell def: "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:2000011 ! dermis lymphatic vessel endothelial cell intersection_of: CL:2000011 ! dermis lymphatic vessel endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium relationship: part_of UBERON:0008339 ! microvascular endothelium created_by: TermGenie creation_date: 2014-07-09T00:09:54Z [Term] id: CL:2000042 name: embryonic fibroblast namespace: cell def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo created_by: TermGenie creation_date: 2014-07-09T00:12:00Z [Term] id: CL:2000043 name: brain pericyte namespace: cell def: "Any pericyte cell that is part of a brain." [GOC:TermGenie] is_a: CL:0000669 ! pericyte cell intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain created_by: TermGenie creation_date: 2014-07-09T00:18:22Z [Term] id: CL:2000044 name: brain microvascular endothelial cell namespace: cell def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain created_by: TermGenie creation_date: 2014-07-09T00:24:53Z [Term] id: CL:2000045 name: foreskin melanocyte namespace: cell def: "Any melanocyte that is part of a prepuce of penis." [GOC:TermGenie] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0001332 ! prepuce of penis relationship: part_of UBERON:0001332 ! prepuce of penis created_by: TermGenie creation_date: 2014-07-09T00:45:07Z [Term] id: CL:2000046 name: ventricular cardiac muscle cell namespace: cell def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle created_by: TermGenie creation_date: 2014-08-12T20:50:28Z [Term] id: CL:2000047 name: brainstem motor neuron namespace: cell def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] is_a: CL:0000100 ! motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: part_of UBERON:0002298 ! brainstem relationship: part_of UBERON:0002298 ! brainstem created_by: TermGenie creation_date: 2014-10-02T23:52:53Z [Term] id: CL:2000048 name: ventral horn of spinal cord spinal cord motor neuron namespace: cell def: "Any spinal cord motor neuron that is part of a ventral horn of spinal cord." [GOC:TermGenie] is_a: CL:0011001 ! spinal cord motor neuron intersection_of: CL:0011001 ! spinal cord motor neuron intersection_of: part_of UBERON:0002257 ! ventral horn of spinal cord relationship: part_of UBERON:0002257 ! ventral horn of spinal cord created_by: TermGenie creation_date: 2014-10-03T00:26:27Z [Term] id: CL:2000049 name: primary motor cortex pyramidal cell namespace: cell def: "Any pyramidal cell that is part of a primary motor cortex." [GOC:TermGenie] comment: http://www.ncbi.nlm.nih.gov/pubmed/12524689 is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: part_of UBERON:0001384 ! primary motor cortex relationship: part_of UBERON:0001384 ! primary motor cortex created_by: TermGenie creation_date: 2014-10-06T17:39:04Z [Term] id: CL:2000050 name: obsolete retina retinal ganglion cell namespace: cell def: "Any retinal ganglion cell that is part of a retina." [GOC:TermGenie] comment: http://www.ncbi.nlm.nih.gov/pubmed/2889210 is_obsolete: true created_by: TermGenie creation_date: 2014-10-06T17:43:59Z [Term] id: CL:2000051 name: splenic fibroblast namespace: cell def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-10-06T18:58:47Z [Term] id: CL:2000052 name: umbilical artery endothelial cell namespace: cell def: "Any endothelial cell of artery that is part of a umbilical cord." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=8010 is_a: CL:0000349 ! extraembryonic cell is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:1000413 ! endothelial cell of artery intersection_of: part_of UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0002331 ! umbilical cord created_by: TermGenie creation_date: 2014-10-06T19:01:48Z [Term] id: CL:2000053 name: splenic endothelial cell namespace: cell def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-10-06T19:06:04Z [Term] id: CL:2000054 name: hepatic pit cell namespace: cell def: "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid." [GOC:dos, PMID:9408963] comment: Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit. is_a: CL:0000623 ! natural killer cell relationship: has_part GO:0030141 ! secretory granule relationship: RO:0001025 UBERON:0001281 ! hepatic sinusoid creation_date: 2014-10-06T19:08:51Z [Term] id: CL:2000055 name: liver dendritic cell namespace: cell def: "Any dendritic cell that is part of a liver." [GOC:TermGenie] comment: http://www.jleukbio.org/content/66/2/322.abstract is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: TermGenie creation_date: 2014-10-06T19:16:11Z [Term] id: CL:2000056 name: Meynert cell namespace: cell def: "Any pyramidal cell that is part of a regional part of cerebral cortex." [GOC:TermGenie] is_a: CL:0000598 ! pyramidal neuron is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000598 ! pyramidal neuron intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex created_by: TermGenie creation_date: 2014-10-06T19:20:41Z [Term] id: CL:2000057 name: femural osteoblast namespace: cell def: "Any osteoblast that is part of a femur." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4610 is_a: CL:0000062 ! osteoblast is_a: CL:0001035 ! bone cell intersection_of: CL:0000062 ! osteoblast intersection_of: part_of UBERON:0000981 ! femur relationship: part_of UBERON:0000981 ! femur created_by: TermGenie creation_date: 2014-10-06T19:29:45Z [Term] id: CL:2000058 name: calvarial osteoblast namespace: cell def: "Any osteoblast that is part of a skull." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4600 is_a: CL:0000062 ! osteoblast intersection_of: CL:0000062 ! osteoblast intersection_of: part_of UBERON:0003129 ! skull relationship: part_of UBERON:0003129 ! skull created_by: TermGenie creation_date: 2014-10-06T19:48:30Z [Term] id: CL:2000059 name: prostate gland microvascular endothelial cell namespace: cell def: "Any microvascular endothelial cell that is part of a prostate gland." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4400 is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: TermGenie creation_date: 2014-10-07T17:46:27Z [Term] id: CL:2000060 name: placental villous trophoblast namespace: cell def: "Any trophoblast cell that is part of a placenta." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7120 is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: TermGenie creation_date: 2014-10-07T17:48:27Z [Term] id: CL:2000061 name: placental amniotic mesenchymal stromal cell namespace: cell def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140 is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: TermGenie creation_date: 2014-10-07T17:51:11Z [Term] id: CL:2000062 name: placental villus capillary endothelial cell namespace: cell def: "Any capillary endothelial cell that is part of a placenta." [GOC:TermGenie] comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/ is_a: CL:0002144 ! capillary endothelial cell is_a: CL:0002577 ! placental epithelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: TermGenie creation_date: 2014-10-07T17:55:56Z [Term] id: CL:2000063 name: ovarian fibroblast namespace: cell def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad created_by: TermGenie creation_date: 2014-10-07T17:57:42Z [Term] id: CL:2000064 name: ovarian surface epithelial cell namespace: cell def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad created_by: TermGenie creation_date: 2014-10-07T17:59:13Z [Term] id: CL:2000065 name: ovarian microvascular endothelial cell namespace: cell def: "Any microvascular endothelial cell that is part of a female urethra." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7300 is_a: CL:1000296 ! epithelial cell of urethra is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0001334 ! female urethra relationship: part_of UBERON:0001334 ! female urethra created_by: TermGenie creation_date: 2014-10-07T18:18:01Z [Term] id: CL:2000066 name: cardiac ventricle fibroblast namespace: cell def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle created_by: TermGenie creation_date: 2014-10-07T18:35:38Z [Term] id: CL:2000067 name: cardiac atrium fibroblast namespace: cell def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium created_by: TermGenie creation_date: 2014-10-07T18:36:54Z [Term] id: CL:2000068 name: pericardium fibroblast namespace: cell def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 is_a: CL:0000057 ! fibroblast is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002407 ! pericardium relationship: part_of UBERON:0002407 ! pericardium created_by: TermGenie creation_date: 2014-10-07T18:38:06Z [Term] id: CL:2000069 name: gallbladder fibroblast namespace: cell def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002110 ! gall bladder relationship: part_of UBERON:0002110 ! gall bladder created_by: TermGenie creation_date: 2014-10-07T18:41:43Z [Term] id: CL:2000070 name: optic choroid fibroblast namespace: cell def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001776 ! optic choroid relationship: part_of UBERON:0001776 ! optic choroid created_by: TermGenie creation_date: 2014-10-07T18:50:43Z [Term] id: CL:2000071 name: mammary microvascular endothelial cell namespace: cell def: "Any microvascular endothelial cell that is part of a breast." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7600 is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0000310 ! breast relationship: part_of UBERON:0000310 ! breast created_by: TermGenie creation_date: 2014-10-07T19:55:30Z [Term] id: CL:2000072 name: adipose microvascular endothelial cell namespace: cell def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue created_by: TermGenie creation_date: 2014-10-07T22:13:45Z [Term] id: CL:2000073 name: migratory cardiac neural crest cell namespace: cell def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: part_of UBERON:0000095 ! cardiac neural crest relationship: part_of UBERON:0000095 ! cardiac neural crest created_by: TermGenie creation_date: 2014-11-05T01:18:43Z [Term] id: CL:2000074 name: splenocyte namespace: cell def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-11-05T01:26:50Z [Term] id: CL:2000075 name: anterior visceral endoderm cell namespace: cell def: "Any endodermal cell that is part of a anterior visceral endoderm." [GOC:TermGenie] is_a: CL:0000223 ! endodermal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000223 ! endodermal cell intersection_of: part_of UBERON:0004044 ! anterior visceral endoderm relationship: part_of UBERON:0004044 ! anterior visceral endoderm created_by: TermGenie creation_date: 2014-11-05T01:34:13Z [Term] id: CL:2000076 name: hindlimb stylopod vein endothelial cell namespace: cell def: "Any vein endothelial cell that is part of a hindlimb stylopod." [GOC:TermGenie] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: part_of UBERON:0000376 ! hindlimb stylopod relationship: part_of UBERON:0000376 ! hindlimb stylopod created_by: TermGenie creation_date: 2014-12-02T18:40:47Z [Term] id: CL:2000077 name: skeletal muscle tissue of pectoralis major striated muscle cell namespace: cell def: "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." [GOC:TermGenie] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000737 ! striated muscle cell intersection_of: part_of UBERON:0004510 ! skeletal muscle tissue of pectoralis major relationship: part_of UBERON:0004510 ! skeletal muscle tissue of pectoralis major created_by: TermGenie creation_date: 2014-12-02T18:48:17Z [Term] id: CL:2000078 name: placental pericyte namespace: cell def: "Any pericyte cell that is part of a placenta." [GOC:TermGenie] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0000669 ! pericyte cell intersection_of: CL:0000669 ! pericyte cell intersection_of: part_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta created_by: TermGenie creation_date: 2014-12-02T18:51:03Z [Term] id: CL:2000079 name: mesenchymal stem cell of femoral bone marrow namespace: cell def: "Any mesenchymal stem cell of the bone marrow that is part of a femur." [GOC:TermGenie] is_a: CL:0002092 ! bone marrow cell is_a: CL:0002540 ! mesenchymal stem cell of the bone marrow intersection_of: CL:0002540 ! mesenchymal stem cell of the bone marrow intersection_of: part_of UBERON:0000981 ! femur relationship: part_of UBERON:0000981 ! femur created_by: TermGenie creation_date: 2014-12-02T19:07:31Z [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose namespace: cell def: "Any mesenchymal stem cell of adipose that is part of a abdomen." [GOC:TermGenie] is_a: CL:0002570 ! mesenchymal stem cell of adipose intersection_of: CL:0002570 ! mesenchymal stem cell of adipose intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen created_by: TermGenie creation_date: 2014-12-02T19:10:34Z [Term] id: CL:2000081 name: melanocyte of skin of face namespace: cell def: "Any melanocyte of skin that is part of a skin of face." [GOC:TermGenie] is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:1000458 ! melanocyte of skin intersection_of: part_of UBERON:1000021 ! skin of face relationship: part_of UBERON:1000021 ! skin of face created_by: TermGenie creation_date: 2014-12-02T19:10:40Z [Term] id: CL:2000082 name: melanocyte of foreskin namespace: cell def: "Any melanocyte of skin that is part of a skin of prepuce of penis." [GOC:TermGenie] is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:1000458 ! melanocyte of skin intersection_of: part_of UBERON:0001471 ! skin of prepuce of penis relationship: part_of UBERON:0001471 ! skin of prepuce of penis created_by: TermGenie creation_date: 2014-12-02T19:10:45Z [Term] id: CL:2000083 name: hair follicle dermal papilla cell of scalp namespace: cell def: "Any hair follicle dermal papilla cell that is part of a scalp." [GOC:TermGenie] is_a: CL:0000346 ! hair follicle dermal papilla cell intersection_of: CL:0000346 ! hair follicle dermal papilla cell intersection_of: part_of UBERON:0000403 ! scalp relationship: part_of UBERON:0000403 ! scalp created_by: TermGenie creation_date: 2014-12-02T19:10:50Z [Term] id: CL:2000084 name: conjunctiva goblet cell namespace: cell def: "Any goblet cell that is part of a conjunctiva." [GOC:TermGenie] is_a: CL:0000160 ! goblet cell is_a: CL:1000432 ! conjunctival epithelial cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva created_by: TermGenie creation_date: 2014-12-02T19:28:38Z [Term] id: CL:2000085 name: mononuclear cell of umbilical cord namespace: cell def: "Any mononuclear cell that is part of a umbilical cord." [GOC:TermGenie] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0002331 ! umbilical cord created_by: TermGenie creation_date: 2014-12-02T20:14:16Z [Term] id: CL:2000086 name: neocortex basket cell namespace: cell def: "Any basket cell that is part of a neocortex." [GOC:TermGenie] is_a: CL:0000118 ! basket cell intersection_of: CL:0000118 ! basket cell intersection_of: part_of UBERON:0001950 ! neocortex relationship: part_of UBERON:0001950 ! neocortex created_by: TermGenie creation_date: 2014-12-24T00:37:19Z [Term] id: CL:2000087 name: dentate gyrus of hippocampal formation basket cell namespace: cell def: "Any basket cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie] is_a: CL:0000118 ! basket cell intersection_of: CL:0000118 ! basket cell intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation created_by: TermGenie creation_date: 2014-12-24T00:37:24Z [Term] id: CL:2000088 name: Ammon's horn basket cell namespace: cell def: "Any basket cell that is part of a Ammon's horn." [GOC:TermGenie] is_a: CL:0000118 ! basket cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000118 ! basket cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn created_by: TermGenie creation_date: 2014-12-24T00:37:30Z [Term] id: CL:2000089 name: dentate gyrus of hippocampal formation granule cell namespace: cell def: "The principal cell type of the dentate gyrus." [GOC:TermGenie] comment: The granule cell has a characteristic cone-shaped tree of spiny apical dendrites. is_a: CL:0000120 ! granule cell intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation created_by: TermGenie creation_date: 2015-02-23T05:48:23Z [Term] id: CL:2000090 name: dentate gyrus of hippocampal formation stellate cell namespace: cell def: "Any stellate cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie] is_a: CL:0000122 ! stellate cell intersection_of: CL:0000122 ! stellate cell intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation created_by: TermGenie creation_date: 2015-02-23T05:48:40Z [Term] id: CL:2000091 name: endometrial microvascular endothelial cells namespace: cell def: "Any microvascular endothelial cell that is part of a endometrial blood vessel." [GOC:TermGenie] is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0015172 ! endometrial blood vessel relationship: part_of UBERON:0015172 ! endometrial blood vessel created_by: TermGenie creation_date: 2015-03-31T21:02:36Z [Term] id: CL:2000092 name: hair follicular keratinocyte namespace: cell def: "Any keratinocyte that is part of a hair follicle." [GOC:TermGenie] is_a: CL:0000312 ! keratinocyte is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000312 ! keratinocyte intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: TermGenie creation_date: 2015-03-31T21:07:02Z [Term] id: CL:2000093 name: bronchus fibroblast of lung namespace: cell def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: TermGenie creation_date: 2015-03-31T21:16:22Z [Term] id: CL:2000094 name: nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa namespace: cell def: "Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium." [GOC:TermGenie] is_a: CL:1000441 ! epithelial cell of viscerocranial mucosa intersection_of: CL:1000441 ! epithelial cell of viscerocranial mucosa intersection_of: part_of UBERON:0005385 ! nasal cavity respiratory epithelium relationship: part_of UBERON:0005385 ! nasal cavity respiratory epithelium created_by: TermGenie creation_date: 2015-03-31T22:25:17Z [Term] id: CLO:0000001 name: cell line cell is_a: CL:0000010 ! cultured cell [Term] id: CLO:0000018 name: mortal cell line cell is_a: CLO:0000001 ! cell line cell [Term] id: CLO:0000019 name: immortal cell line cell is_a: CLO:0000001 ! cell line cell [Term] id: CP:0000000 name: neutrophillic cytoplasm namespace: cell def: "Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm created_by: tmeehan creation_date: 2010-05-25T01:36:34Z [Term] id: CP:0000025 name: lobed nucleus namespace: cell def: "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0001979 ! lobed relationship: bearer_of PATO:0001979 ! lobed created_by: tmeehan creation_date: 2009-12-22T03:54:43Z [Term] id: CP:0000027 name: acidophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits molecular interaction for acidic dyes under specific pH conditions." [GOC:tfm] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 ! cytoplasm created_by: tmeehan creation_date: 2009-12-22T04:23:25Z [Term] id: CP:0000028 name: basophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: bearer_of PATO:0002094 ! basophilic relationship: bearer_of PATO:0002094 ! basophilic created_by: tmeehan creation_date: 2009-12-22T04:24:54Z [Term] id: CP:0000035 name: polychromatophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm created_by: tmeehan creation_date: 2009-12-28T04:25:23Z [Term] id: CP:0000037 name: increased nucleus size namespace: cell def: "A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0000586 ! increased size relationship: bearer_of PATO:0000586 ! increased size created_by: tmeehan creation_date: 2009-12-23T10:53:24Z [Term] id: CP:0000039 name: banded nucleus namespace: cell def: "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." [GOC:tfm] is_a: GO:0005634 ! nucleus created_by: tmeehan creation_date: 2009-12-23T02:18:43Z [Term] id: CP:0000040 name: reniform nucleus namespace: cell def: "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0001871 ! reniform relationship: bearer_of PATO:0001871 ! reniform created_by: tmeehan creation_date: 2009-12-23T02:31:25Z [Term] id: CP:0000043 name: cartwheel heterochromatin namespace: cell def: "Heterochromatin that is arranged in a carthwheel pattern." [GOC:tfm] is_a: GO:0000792 ! heterochromatin created_by: tmeehan creation_date: 2009-12-28T04:28:35Z [Term] id: GO:0000018 name: regulation of DNA recombination is_a: GO:0051052 ! regulation of DNA metabolic process [Term] id: GO:0000226 name: microtubule cytoskeleton organization is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0000278 name: mitotic cell cycle is_a: GO:0007049 ! cell cycle [Term] id: GO:0000280 name: nuclear division is_a: GO:0048285 ! organelle fission [Term] id: GO:0000323 name: lytic vacuole is_a: GO:0005773 ! vacuole [Term] id: GO:0000785 name: chromatin is_a: GO:0032991 ! macromolecular complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000791 name: euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0001505 name: regulation of neurotransmitter levels is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0001578 name: microtubule bundle formation is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001649 name: osteoblast differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0001667 name: ameboidal-type cell migration is_a: GO:0016477 ! cell migration [Term] id: GO:0001675 name: acrosome assembly is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033363 ! secretory granule organization is_a: GO:0044702 ! single organism reproductive process is_a: GO:0070925 ! organelle assembly is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0001773 name: myeloid dendritic cell activation is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001775 name: cell activation is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0001816 name: cytokine production is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0001817 name: regulation of cytokine production is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0001818 name: negative regulation of cytokine production is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process [Term] id: GO:0001820 name: serotonin secretion is_a: GO:0006837 ! serotonin transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001894 name: tissue homeostasis is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0001906 name: cell killing is_a: GO:0008150 ! biological_process [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity is_a: GO:0001906 ! cell killing is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0001913 name: T cell mediated cytotoxicity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0044699 ! single-organism process [Term] id: GO:0001974 name: blood vessel remodeling is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0002001 name: renin secretion into blood stream is_a: GO:0009306 ! protein secretion [Term] id: GO:0002200 name: somatic diversification of immune receptors is_a: GO:0002376 ! immune system process [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002215 name: defense response to nematode is_a: GO:0009624 ! response to nematode is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002227 name: innate immune response in mucosa is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002249 name: lymphocyte anergy is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process is_a: GO:0002376 ! immune system process [Term] id: GO:0002263 name: cell activation involved in immune response is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process [Term] id: GO:0002274 name: myeloid leukocyte activation is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002285 name: lymphocyte activation involved in immune response is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0002286 name: T cell activation involved in immune response is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0002288 name: NK T cell activation involved in immune response is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0002312 name: B cell activation involved in immune response is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0002314 name: germinal center B cell differentiation is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002335 name: mature B cell differentiation is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002339 name: B cell selection is_a: GO:0002376 ! immune system process [Term] id: GO:0002343 name: peripheral B cell selection is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation is_a: GO:0002343 ! peripheral B cell selection [Term] id: GO:0002349 name: histamine production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002351 name: serotonin production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002366 name: leukocyte activation involved in immune response is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002367 name: cytokine production involved in immune response is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002369 name: T cell cytokine production is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002376 name: immune system process is_a: GO:0008150 ! biological_process [Term] id: GO:0002385 name: mucosal immune response is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002432 name: granuloma formation is_a: GO:0002252 ! immune effector process [Term] id: GO:0002440 name: production of molecular mediator of immune response is_a: GO:0002376 ! immune system process [Term] id: GO:0002443 name: leukocyte mediated immunity is_a: GO:0002252 ! immune effector process [Term] id: GO:0002449 name: lymphocyte mediated immunity is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002456 name: T cell mediated immunity is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002507 name: tolerance induction is_a: GO:0002376 ! immune system process [Term] id: GO:0002514 name: B cell tolerance induction is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002521 name: leukocyte differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonic acid metabolite production involved in inflammatory response is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002548 name: monocyte chemotaxis is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002573 name: myeloid leukocyte differentiation is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002634 name: regulation of germinal center formation is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0022603 ! regulation of anatomical structure morphogenesis [Term] id: GO:0002637 name: regulation of immunoglobulin production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response [Term] id: GO:0002639 name: positive regulation of immunoglobulin production is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response [Term] id: GO:0002643 name: regulation of tolerance induction is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:0002645 name: positive regulation of tolerance induction is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002658 name: regulation of peripheral tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction [Term] id: GO:0002679 name: respiratory burst involved in defense response is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst [Term] id: GO:0002682 name: regulation of immune system process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0002683 name: negative regulation of immune system process is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process [Term] id: GO:0002684 name: positive regulation of immune system process is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0002685 name: regulation of leukocyte migration is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis [Term] id: GO:0002694 name: regulation of leukocyte activation is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation [Term] id: GO:0002697 name: regulation of immune effector process is_a: GO:0002682 ! regulation of immune system process [Term] id: GO:0002699 name: positive regulation of immune effector process is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response is_a: GO:0002697 ! regulation of immune effector process [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity is_a: GO:0002697 ! regulation of immune effector process [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity is_a: GO:0002703 ! regulation of leukocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002775 name: antimicrobial peptide production is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002776 name: antimicrobial peptide secretion is_a: GO:0002790 ! peptide secretion [Term] id: GO:0002790 name: peptide secretion is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002819 name: regulation of adaptive immune response is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002819 ! regulation of adaptive immune response [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002830 name: positive regulation of type 2 immune response is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response is_a: GO:0002712 ! regulation of B cell mediated immunity [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response [Term] id: GO:0002902 name: regulation of B cell apoptotic process is_a: GO:0070228 ! regulation of lymphocyte apoptotic process [Term] id: GO:0002905 name: regulation of mature B cell apoptotic process is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0032844 ! regulation of homeostatic process [Term] id: GO:0003006 name: developmental process involved in reproduction is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process [Term] id: GO:0003008 name: system process is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0003013 name: circulatory system process is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003674 name: molecular_function [Term] id: GO:0004871 name: signal transducer activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0004872 name: receptor activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0004888 name: transmembrane signaling receptor activity is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0005044 name: scavenger receptor activity is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0005215 name: transporter activity is_a: GO:0003674 ! molecular_function [Term] id: GO:0005319 name: lipid transporter activity is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0005342 name: organic acid transmembrane transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0005488 name: binding is_a: GO:0003674 ! molecular_function [Term] id: GO:0005575 name: cellular_component [Term] id: GO:0005623 name: cell is_a: CARO:0000003 ! anatomical structure is_a: GO:0005575 ! cellular_component [Term] id: GO:0005634 name: nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044464 ! cell part [Term] id: GO:0005730 name: nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044428 ! nuclear part [Term] id: GO:0005737 name: cytoplasm is_a: GO:0044424 ! intracellular part [Term] id: GO:0005764 name: lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005766 name: primary lysosome is_a: GO:0005764 ! lysosome [Term] id: GO:0005773 name: vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005794 name: Golgi apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005840 name: ribosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005902 name: microvillus is_a: GO:0042995 ! cell projection [Term] id: GO:0005911 name: cell-cell junction is_a: GO:0030054 ! cell junction [Term] id: GO:0005929 name: cilium is_a: GO:0042995 ! cell projection is_a: GO:0043226 ! organelle [Term] id: GO:0006022 name: aminoglycan metabolic process is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006023 name: aminoglycan biosynthetic process is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006082 name: organic acid metabolic process is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006259 name: DNA metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006310 name: DNA recombination is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006323 name: DNA packaging is_a: GO:0016043 ! cellular component organization is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006629 name: lipid metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006694 name: steroid biosynthetic process is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006699 name: bile acid biosynthetic process is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0006725 name: cellular aromatic compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006801 name: superoxide metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0006807 name: nitrogen compound metabolic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0006810 name: transport is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: ion transport is_a: GO:0044765 ! single-organism transport [Term] id: GO:0006812 name: cation transport is_a: GO:0006811 ! ion transport [Term] id: GO:0006820 name: anion transport is_a: GO:0006811 ! ion transport [Term] id: GO:0006835 name: dicarboxylic acid transport is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006836 name: neurotransmitter transport is_a: GO:0044765 ! single-organism transport [Term] id: GO:0006837 name: serotonin transport is_a: GO:0006812 ! cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0006865 name: amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0006869 name: lipid transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0006897 name: endocytosis is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006909 name: phagocytosis is_a: GO:0006897 ! endocytosis is_a: GO:0044765 ! single-organism transport [Term] id: GO:0006928 name: movement of cell or subcellular component is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0006935 name: chemotaxis is_a: GO:0042330 ! taxis [Term] id: GO:0006937 name: regulation of muscle contraction is_a: GO:0090257 ! regulation of muscle system process [Term] id: GO:0006940 name: regulation of smooth muscle contraction is_a: GO:0006937 ! regulation of muscle contraction [Term] id: GO:0006950 name: response to stress is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response is_a: GO:0006952 ! defense response [Term] id: GO:0006955 name: immune response is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006996 name: organelle organization is_a: GO:0009987 ! cellular process is_a: GO:0016043 ! cellular component organization [Term] id: GO:0006997 name: nucleus organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0007010 name: cytoskeleton organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0007017 name: microtubule-based process is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007049 name: cell cycle is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007067 name: mitotic nuclear division is_a: GO:0000280 ! nuclear division is_a: GO:0022402 ! cell cycle process is_a: GO:1902589 ! single-organism organelle organization is_a: GO:1903047 ! mitotic cell cycle process [Term] id: GO:0007113 name: endomitotic cell cycle is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007126 name: meiotic nuclear division is_a: GO:0000280 ! nuclear division [Term] id: GO:0007135 name: meiosis II is_a: GO:0007126 ! meiotic nuclear division is_a: GO:0022402 ! cell cycle process is_a: GO:1902589 ! single-organism organelle organization is_a: GO:1903046 ! meiotic cell cycle process [Term] id: GO:0007140 name: male meiosis is_a: GO:0007126 ! meiotic nuclear division [Term] id: GO:0007142 name: male meiosis II is_a: GO:0007135 ! meiosis II [Term] id: GO:0007143 name: female meiotic division is_a: GO:0007126 ! meiotic nuclear division [Term] id: GO:0007147 name: female meiosis II is_a: GO:0007135 ! meiosis II [Term] id: GO:0007154 name: cell communication is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0007155 name: cell adhesion is_a: GO:0022610 ! biological adhesion [Term] id: GO:0007159 name: leukocyte cell-cell adhesion is_a: GO:0016337 ! single organismal cell-cell adhesion [Term] id: GO:0007162 name: negative regulation of cell adhesion is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process [Term] id: GO:0007267 name: cell-cell signaling is_a: GO:0007154 ! cell communication is_a: GO:0044700 ! single organism signaling [Term] id: GO:0007269 name: neurotransmitter secretion is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0023061 ! signal release [Term] id: GO:0007276 name: gamete generation is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0007281 name: germ cell development is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048468 ! cell development [Term] id: GO:0007283 name: spermatogenesis is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007288 name: sperm axoneme assembly is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0035082 ! axoneme assembly is_a: GO:0044702 ! single organism reproductive process [Term] id: GO:0007289 name: spermatid nucleus differentiation is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0007292 name: female gamete generation is_a: GO:0007276 ! gamete generation [Term] id: GO:0007585 name: respiratory gaseous exchange is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0007589 name: body fluid secretion is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007596 name: blood coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation [Term] id: GO:0007599 name: hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0008015 name: blood circulation is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0008104 name: protein localization is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008150 name: biological_process [Term] id: GO:0008152 name: metabolic process is_a: GO:0008150 ! biological_process [Term] id: GO:0008202 name: steroid metabolic process is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0008206 name: bile acid metabolic process is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0008283 name: cell proliferation is_a: GO:0044699 ! single-organism process [Term] id: GO:0008284 name: positive regulation of cell proliferation is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048522 ! positive regulation of cellular process [Term] id: GO:0008285 name: negative regulation of cell proliferation is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048523 ! negative regulation of cellular process [Term] id: GO:0008289 name: lipid binding is_a: GO:0005488 ! binding [Term] id: GO:0008509 name: anion transmembrane transporter activity is_a: GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0008514 name: organic anion transmembrane transporter activity is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0008610 name: lipid biosynthetic process is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009058 name: biosynthetic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0009059 name: macromolecule biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009266 name: response to temperature stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009306 name: protein secretion is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0009314 name: response to radiation is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009399 name: nitrogen fixation is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0009411 name: response to UV is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009416 name: response to light stimulus is_a: GO:0009314 ! response to radiation [Term] id: GO:0009566 name: fertilization is_a: GO:0044702 ! single organism reproductive process [Term] id: GO:0009581 name: detection of external stimulus is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009589 name: detection of UV is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009593 name: detection of chemical stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009605 name: response to external stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009612 name: response to mechanical stimulus is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009617 name: response to bacterium is_a: GO:0051707 ! response to other organism [Term] id: GO:0009624 name: response to nematode is_a: GO:0051707 ! response to other organism [Term] id: GO:0009628 name: response to abiotic stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009629 name: response to gravity is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis is_a: GO:0032502 ! developmental process [Term] id: GO:0009887 name: organ morphogenesis is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0009893 name: positive regulation of metabolic process is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0009914 name: hormone transport is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0044765 ! single-organism transport [Term] id: GO:0009987 name: cellular process is_a: GO:0008150 ! biological_process [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process [Term] id: GO:0010817 name: regulation of hormone levels is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis is_a: GO:0022607 ! cellular component assembly is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0010941 name: regulation of cell death is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0012506 name: vesicle membrane is_a: GO:0031090 ! organelle membrane [Term] id: GO:0014046 name: dopamine secretion is_a: GO:0015872 ! dopamine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0014047 name: glutamate secretion is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006865 ! amino acid transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion [Term] id: GO:0014704 name: intercalated disc is_a: GO:0044291 ! cell-cell contact zone [Term] id: GO:0015031 name: protein transport is_a: GO:0008104 ! protein localization is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015075 name: ion transmembrane transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0015103 name: inorganic anion transmembrane transporter activity is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015125 name: bile acid transmembrane transporter activity is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015126 name: canalicular bile acid transmembrane transporter activity is_a: GO:0015125 ! bile acid transmembrane transporter activity [Term] id: GO:0015669 name: gas transport is_a: GO:0044765 ! single-organism transport [Term] id: GO:0015671 name: oxygen transport is_a: GO:0015669 ! gas transport [Term] id: GO:0015672 name: monovalent inorganic cation transport is_a: GO:0006812 ! cation transport [Term] id: GO:0015695 name: organic cation transport is_a: GO:0006812 ! cation transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015696 name: ammonium transport is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0015698 ! inorganic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015698 name: inorganic anion transport is_a: GO:0006820 ! anion transport [Term] id: GO:0015711 name: organic anion transport is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015718 name: monocarboxylic acid transport is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0015721 name: bile acid and bile salt transport is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015740 name: C4-dicarboxylate transport is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015800 name: acidic amino acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015807 name: L-amino acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015810 name: aspartate transport is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015800 ! acidic amino acid transport [Term] id: GO:0015812 name: gamma-aminobutyric acid transport is_a: GO:0006865 ! amino acid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015816 name: glycine transport is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport [Term] id: GO:0015833 name: peptide transport is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015844 name: monoamine transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015849 name: organic acid transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015850 name: organic hydroxy compound transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015870 name: acetylcholine transport is_a: GO:0006812 ! cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport [Term] id: GO:0015872 name: dopamine transport is_a: GO:0006812 ! cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015874 name: norepinephrine transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0016020 name: membrane is_a: GO:0005575 ! cellular_component [Term] id: GO:0016023 name: cytoplasmic membrane-bounded vesicle is_a: GO:0031410 ! cytoplasmic vesicle is_a: GO:0031988 ! membrane-bounded vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0016043 name: cellular component organization is_a: GO:0009987 ! cellular process is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016048 name: detection of temperature stimulus is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0016050 name: vesicle organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0016053 name: organic acid biosynthetic process is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0016192 name: vesicle-mediated transport is_a: GO:0006810 ! transport [Term] id: GO:0016337 name: single organismal cell-cell adhesion is_a: GO:0098602 ! single organism cell adhesion is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0016444 name: somatic cell DNA recombination is_a: GO:0006310 ! DNA recombination [Term] id: GO:0016445 name: somatic diversification of immunoglobulins is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0016446 name: somatic hypermutation of immunoglobulin genes is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016447 name: somatic recombination of immunoglobulin gene segments is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016477 name: cell migration is_a: GO:0048870 ! cell motility [Term] id: GO:0017144 name: drug metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0017145 name: stem cell division is_a: GO:0051301 ! cell division [Term] id: GO:0018130 name: heterocycle biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process [Term] id: GO:0019222 name: regulation of metabolic process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0019226 name: transmission of nerve impulse is_a: GO:0035637 ! multicellular organismal signaling is_a: GO:0050877 ! neurological system process [Term] id: GO:0019438 name: aromatic compound biosynthetic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019724 name: B cell mediated immunity is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0019752 name: carboxylic acid metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019814 name: immunoglobulin complex is_a: GO:0043234 ! protein complex [Term] id: GO:0019815 name: B cell receptor complex is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0098802 ! plasma membrane receptor complex [Term] id: GO:0019882 name: antigen processing and presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019884 name: antigen processing and presentation of exogenous antigen is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0021700 name: developmental maturation is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0022402 name: cell cycle process is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion is_a: GO:0030155 ! regulation of cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0022414 name: reproductive process is_a: GO:0008150 ! biological_process [Term] id: GO:0022602 name: ovulation cycle process is_a: GO:0044699 ! single-organism process is_a: GO:0048511 ! rhythmic process [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0022607 name: cellular component assembly is_a: GO:0016043 ! cellular component organization [Term] id: GO:0022610 name: biological adhesion is_a: GO:0008150 ! biological_process [Term] id: GO:0022857 name: transmembrane transporter activity is_a: GO:0005215 ! transporter activity [Term] id: GO:0022891 name: substrate-specific transmembrane transporter activity is_a: GO:0022857 ! transmembrane transporter activity is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0022892 name: substrate-specific transporter activity is_a: GO:0005215 ! transporter activity [Term] id: GO:0023052 name: signaling is_a: GO:0008150 ! biological_process [Term] id: GO:0023061 name: signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0030017 name: sarcomere is_a: GO:0044449 ! contractile fiber part [Term] id: GO:0030030 name: cell projection organization is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0030031 name: cell projection assembly is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization [Term] id: GO:0030054 name: cell junction is_a: GO:0005575 ! cellular_component [Term] id: GO:0030072 name: peptide hormone secretion is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion [Term] id: GO:0030073 name: insulin secretion is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030098 name: lymphocyte differentiation is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030099 name: myeloid cell differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0030103 name: vasopressin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030141 name: secretory granule is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0030154 name: cell differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030155 name: regulation of cell adhesion is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0030182 name: neuron differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0030183 name: B cell differentiation is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation [Term] id: GO:0030186 name: melatonin metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0030187 name: melatonin biosynthetic process is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0030202 name: heparin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process [Term] id: GO:0030203 name: glycosaminoglycan metabolic process is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0030210 name: heparin biosynthetic process is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0030217 name: T cell differentiation is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation [Term] id: GO:0030218 name: erythrocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0030219 name: megakaryocyte differentiation is_a: GO:0002244 ! hematopoietic progenitor cell differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0030221 name: basophil differentiation is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030222 name: eosinophil differentiation is_a: GO:0030851 ! granulocyte differentiation is_a: GO:0048468 ! cell development [Term] id: GO:0030223 name: neutrophil differentiation is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030224 name: monocyte differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030225 name: macrophage differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030252 name: growth hormone secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030261 name: chromosome condensation is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006323 ! DNA packaging is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization [Term] id: GO:0030263 name: apoptotic chromosome condensation is_a: GO:0030261 ! chromosome condensation [Term] id: GO:0030316 name: osteoclast differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030317 name: sperm motility is_a: GO:0048870 ! cell motility [Term] id: GO:0030334 name: regulation of cell migration is_a: GO:2000145 ! regulation of cell motility [Term] id: GO:0030335 name: positive regulation of cell migration is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility [Term] id: GO:0030529 name: ribonucleoprotein complex is_a: GO:0032991 ! macromolecular complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030595 name: leukocyte chemotaxis is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0030659 name: cytoplasmic vesicle membrane is_a: GO:0012506 ! vesicle membrane is_a: GO:0044433 ! cytoplasmic vesicle part [Term] id: GO:0030667 name: secretory granule membrane is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane [Term] id: GO:0030851 name: granulocyte differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0031090 name: organelle membrane is_a: GO:0016020 ! membrane is_a: GO:0044422 ! organelle part [Term] id: GO:0031268 name: pseudopodium organization is_a: GO:0030030 ! cell projection organization [Term] id: GO:0031294 name: lymphocyte costimulation is_a: GO:0002376 ! immune system process is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0031323 name: regulation of cellular metabolic process is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process [Term] id: GO:0031347 name: regulation of defense response is_a: GO:0080134 ! regulation of response to stress [Term] id: GO:0031348 name: negative regulation of defense response is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus [Term] id: GO:0031349 name: positive regulation of defense response is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus [Term] id: GO:0031410 name: cytoplasmic vesicle is_a: GO:0031982 ! vesicle is_a: GO:0043229 ! intracellular organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031982 name: vesicle is_a: GO:0043226 ! organelle [Term] id: GO:0031988 name: membrane-bounded vesicle is_a: GO:0031982 ! vesicle is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0032101 name: regulation of response to external stimulus is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus [Term] id: GO:0032274 name: gonadotropin secretion is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032275 name: luteinizing hormone secretion is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0032394 name: MHC class Ib receptor activity is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0032501 name: multicellular organismal process is_a: GO:0008150 ! biological_process [Term] id: GO:0032502 name: developmental process is_a: GO:0008150 ! biological_process [Term] id: GO:0032606 name: type I interferon production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032609 name: interferon-gamma production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032611 name: interleukin-1 beta production is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032612 name: interleukin-1 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032613 name: interleukin-10 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032616 name: interleukin-13 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032620 name: interleukin-17 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032623 name: interleukin-2 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032626 name: interleukin-22 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032633 name: interleukin-4 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032635 name: interleukin-6 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032637 name: interleukin-8 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032638 name: interleukin-9 production is_a: GO:0001816 ! cytokine production [Term] id: GO:0032640 name: tumor necrosis factor production is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032649 name: regulation of interferon-gamma production is_a: GO:0001817 ! regulation of cytokine production [Term] id: GO:0032689 name: negative regulation of interferon-gamma production is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production [Term] id: GO:0032782 name: bile acid secretion is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015721 ! bile acid and bile salt transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0032787 name: monocarboxylic acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0032814 name: regulation of natural killer cell activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0032844 name: regulation of homeostatic process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0032879 name: regulation of localization is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0032880 name: regulation of protein localization is_a: GO:0032879 ! regulation of localization [Term] id: GO:0032940 name: secretion by cell is_a: GO:0044763 ! single-organism cellular process is_a: GO:0046903 ! secretion is_a: GO:0051649 ! establishment of localization in cell [Term] id: GO:0032941 name: secretion by tissue is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0046903 ! secretion [Term] id: GO:0032943 name: mononuclear cell proliferation is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation [Term] id: GO:0032991 name: macromolecular complex is_a: GO:0005575 ! cellular_component [Term] id: GO:0032997 name: Fc receptor complex is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0033001 name: Fc-gamma receptor III complex is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033036 name: macromolecule localization is_a: GO:0051179 ! localization [Term] id: GO:0033151 name: V(D)J recombination is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus [Term] id: GO:0033152 name: immunoglobulin V(D)J recombination is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments is_a: GO:0033151 ! V(D)J recombination [Term] id: GO:0033326 name: cerebrospinal fluid secretion is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0033363 name: secretory granule organization is_a: GO:0016050 ! vesicle organization [Term] id: GO:0033365 name: protein localization to organelle is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0033366 name: protein localization to secretory granule is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0033374 name: protein localization to T cell secretory granule is_a: GO:0033366 ! protein localization to secretory granule [Term] id: GO:0033375 name: protease localization to T cell secretory granule is_a: GO:0033374 ! protein localization to T cell secretory granule [Term] id: GO:0033380 name: granzyme B localization to T cell secretory granule is_a: GO:0033375 ! protease localization to T cell secretory granule [Term] id: GO:0034102 name: erythrocyte clearance is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0034109 name: homotypic cell-cell adhesion is_a: GO:0016337 ! single organismal cell-cell adhesion [Term] id: GO:0034110 name: regulation of homotypic cell-cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion [Term] id: GO:0034111 name: negative regulation of homotypic cell-cell adhesion is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion [Term] id: GO:0034112 name: positive regulation of homotypic cell-cell adhesion is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion [Term] id: GO:0034613 name: cellular protein localization is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034754 name: cellular hormone metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0035010 name: encapsulation of foreign target is_a: GO:0002252 ! immune effector process [Term] id: GO:0035051 name: cardiocyte differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0035082 name: axoneme assembly is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly [Term] id: GO:0035369 name: pre-B cell receptor complex is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0035637 name: multicellular organismal signaling is_a: GO:0044700 ! single organism signaling is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0035929 name: steroid hormone secretion is_a: GO:0006869 ! lipid transport is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0035930 name: corticosteroid hormone secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0035931 name: mineralocorticoid secretion is_a: GO:0035930 ! corticosteroid hormone secretion [Term] id: GO:0035933 name: glucocorticoid secretion is_a: GO:0035930 ! corticosteroid hormone secretion [Term] id: GO:0035935 name: androgen secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0035936 name: testosterone secretion is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035935 ! androgen secretion [Term] id: GO:0035937 name: estrogen secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0035938 name: estradiol secretion is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035937 ! estrogen secretion [Term] id: GO:0036160 name: melanocyte-stimulating hormone secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0036161 name: calcitonin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0036321 name: ghrelin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0038001 name: paracrine signaling is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0038023 name: signaling receptor activity is_a: GO:0004871 ! signal transducer activity is_a: GO:0004872 ! receptor activity [Term] id: GO:0038024 name: cargo receptor activity is_a: GO:0004872 ! receptor activity [Term] id: GO:0040011 name: locomotion is_a: GO:0008150 ! biological_process [Term] id: GO:0040012 name: regulation of locomotion is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0040017 name: positive regulation of locomotion is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process [Term] id: GO:0042101 name: T cell receptor complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0098802 ! plasma membrane receptor complex relationship: has_part PR:000001020 {comment="To be added to GO"} ! CD3 epsilon [Term] id: GO:0042105 name: alpha-beta T cell receptor complex is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042106 name: gamma-delta T cell receptor complex is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042110 name: T cell activation is_a: GO:0046649 ! lymphocyte activation is_a: GO:0070489 ! T cell aggregation [Term] id: GO:0042113 name: B cell activation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042127 name: regulation of cell proliferation is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0042129 name: regulation of T cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050863 ! regulation of T cell activation [Term] id: GO:0042130 name: negative regulation of T cell proliferation is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050868 ! negative regulation of T cell activation [Term] id: GO:0042267 name: natural killer cell mediated cytotoxicity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0044699 ! single-organism process [Term] id: GO:0042330 name: taxis is_a: GO:0040011 ! locomotion [Term] id: GO:0042430 name: indole-containing compound metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042435 name: indole-containing compound biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042445 name: hormone metabolic process is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0042446 name: hormone biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042470 name: melanosome is_a: GO:0048770 ! pigment granule [Term] id: GO:0042475 name: odontogenesis of dentin-containing tooth is_a: GO:0042476 ! odontogenesis [Term] id: GO:0042476 name: odontogenesis is_a: GO:0009887 ! organ morphogenesis [Term] id: GO:0042481 name: regulation of odontogenesis is_a: GO:2000027 ! regulation of organ morphogenesis [Term] id: GO:0042483 name: negative regulation of odontogenesis is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process [Term] id: GO:0042492 name: gamma-delta T cell differentiation is_a: GO:0030217 ! T cell differentiation is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0042554 name: superoxide anion generation is_a: GO:0006801 ! superoxide metabolic process [Term] id: GO:0042571 name: immunoglobulin complex, circulating is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0044421 ! extracellular region part [Term] id: GO:0042582 name: azurophil granule is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! secretory granule [Term] id: GO:0042589 name: zymogen granule membrane is_a: GO:0030667 ! secretory granule membrane [Term] id: GO:0042590 name: antigen processing and presentation of exogenous peptide antigen via MHC class I is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0042592 name: homeostatic process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0042611 name: MHC protein complex is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0042613 name: MHC class II protein complex is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042692 name: muscle cell differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0042701 name: progesterone secretion is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0042742 name: defense response to bacterium is_a: GO:0009617 ! response to bacterium is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0042886 name: amide transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042981 name: regulation of apoptotic process is_a: GO:0043067 ! regulation of programmed cell death [Term] id: GO:0042995 name: cell projection is_a: GO:0044464 ! cell part [Term] id: GO:0043011 name: myeloid dendritic cell differentiation is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation [Term] id: GO:0043067 name: regulation of programmed cell death is_a: GO:0010941 ! regulation of cell death [Term] id: GO:0043129 name: surfactant homeostasis is_a: GO:0048875 ! chemical homeostasis within a tissue [Term] id: GO:0043134 name: regulation of hindgut contraction is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044058 ! regulation of digestive system process [Term] id: GO:0043170 name: macromolecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043207 name: response to external biotic stimulus is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043208 name: glycosphingolipid binding is_a: GO:0046625 ! sphingolipid binding is_a: GO:0051861 ! glycolipid binding [Term] id: GO:0043226 name: organelle is_a: GO:0005575 ! cellular_component [Term] id: GO:0043227 name: membrane-bounded organelle is_a: GO:0043226 ! organelle [Term] id: GO:0043228 name: non-membrane-bounded organelle is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle is_a: GO:0043226 ! organelle is_a: GO:0044424 ! intracellular part [Term] id: GO:0043231 name: intracellular membrane-bounded organelle is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043234 name: protein complex is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0043235 name: receptor complex is_a: GO:0043234 ! protein complex [Term] id: GO:0043277 name: apoptotic cell clearance is_a: GO:0006909 ! phagocytosis [Term] id: GO:0043368 name: positive T cell selection is_a: GO:0045058 ! T cell selection [Term] id: GO:0043370 name: regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation [Term] id: GO:0043372 name: positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation [Term] id: GO:0043384 name: pre-T cell receptor complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0098802 ! plasma membrane receptor complex [Term] id: GO:0043436 name: oxoacid metabolic process is_a: GO:0006082 ! organic acid metabolic process [Term] id: GO:0043603 name: cellular amide metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0043604 name: amide biosynthetic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0044057 name: regulation of system process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0044058 name: regulation of digestive system process is_a: GO:0044057 ! regulation of system process [Term] id: GO:0044237 name: cellular metabolic process is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044260 name: cellular macromolecule metabolic process is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044272 name: sulfur compound biosynthetic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044281 name: small molecule metabolic process is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0044283 name: small molecule biosynthetic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044711 ! single-organism biosynthetic process [Term] id: GO:0044291 name: cell-cell contact zone is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0044421 name: extracellular region part is_a: GO:0005575 ! cellular_component [Term] id: GO:0044422 name: organelle part is_a: GO:0005575 ! cellular_component [Term] id: GO:0044424 name: intracellular part is_a: GO:0044464 ! cell part [Term] id: GO:0044425 name: membrane part is_a: GO:0005575 ! cellular_component [Term] id: GO:0044427 name: chromosomal part is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0044428 name: nuclear part is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0044433 name: cytoplasmic vesicle part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0044444 name: cytoplasmic part is_a: GO:0044424 ! intracellular part [Term] id: GO:0044446 name: intracellular organelle part is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part [Term] id: GO:0044449 name: contractile fiber part is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0044459 name: plasma membrane part is_a: GO:0044425 ! membrane part is_a: GO:0044464 ! cell part [Term] id: GO:0044464 name: cell part is_a: CARO:0000014 ! cell part is_a: GO:0005575 ! cellular_component [Term] id: GO:0044699 name: single-organism process is_a: GO:0008150 ! biological_process [Term] id: GO:0044700 name: single organism signaling is_a: GO:0023052 ! signaling is_a: GO:0044699 ! single-organism process [Term] id: GO:0044702 name: single organism reproductive process is_a: GO:0022414 ! reproductive process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044707 name: single-multicellular organism process is_a: GO:0032501 ! multicellular organismal process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044710 name: single-organism metabolic process is_a: GO:0008152 ! metabolic process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044711 name: single-organism biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0044763 name: single-organism cellular process is_a: GO:0009987 ! cellular process is_a: GO:0044699 ! single-organism process [Term] id: GO:0044765 name: single-organism transport is_a: GO:0006810 ! transport is_a: GO:0044699 ! single-organism process is_a: GO:1902578 ! single-organism localization [Term] id: GO:0044767 name: single-organism developmental process is_a: GO:0032502 ! developmental process is_a: GO:0044699 ! single-organism process [Term] id: GO:0045058 name: T cell selection is_a: GO:0002376 ! immune system process [Term] id: GO:0045087 name: innate immune response is_a: GO:0006952 ! defense response is_a: GO:0006955 ! immune response [Term] id: GO:0045117 name: azole transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0045184 name: establishment of protein localization is_a: GO:0051234 ! establishment of localization [Term] id: GO:0045190 name: isotype switching is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0045191 name: regulation of isotype switching is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0050864 ! regulation of B cell activation is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:0045321 name: leukocyte activation is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process [Term] id: GO:0045443 name: juvenile hormone secretion is_a: GO:0046865 ! terpenoid transport is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0045444 name: fat cell differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0045453 name: bone resorption is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0045457 name: ecdysteroid secretion is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0045580 name: regulation of T cell differentiation is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050863 ! regulation of T cell activation [Term] id: GO:0045582 name: positive regulation of T cell differentiation is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0045595 name: regulation of cell differentiation is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0045597 name: positive regulation of cell differentiation is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process [Term] id: GO:0045619 name: regulation of lymphocyte differentiation is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:1902105 ! regulation of leukocyte differentiation [Term] id: GO:0045621 name: positive regulation of lymphocyte differentiation is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1902107 ! positive regulation of leukocyte differentiation [Term] id: GO:0045622 name: regulation of T-helper cell differentiation is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0045624 name: positive regulation of T-helper cell differentiation is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0045625 name: regulation of T-helper 1 cell differentiation is_a: GO:0002825 ! regulation of T-helper 1 type immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation [Term] id: GO:0045627 name: positive regulation of T-helper 1 cell differentiation is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation [Term] id: GO:0045628 name: regulation of T-helper 2 cell differentiation is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation [Term] id: GO:0045630 name: positive regulation of T-helper 2 cell differentiation is_a: GO:0002830 ! positive regulation of type 2 immune response is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation [Term] id: GO:0045730 name: respiratory burst is_a: GO:0044710 ! single-organism metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development [Term] id: GO:0045766 name: positive regulation of angiogenesis is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:1904018 ! positive regulation of vasculature development [Term] id: GO:0045785 name: positive regulation of cell adhesion is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048522 ! positive regulation of cellular process [Term] id: GO:0045830 name: positive regulation of isotype switching is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0050871 ! positive regulation of B cell activation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process [Term] id: GO:0045911 name: positive regulation of DNA recombination is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051054 ! positive regulation of DNA metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process [Term] id: GO:0046394 name: carboxylic acid biosynthetic process is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046483 name: heterocycle metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0046625 name: sphingolipid binding is_a: GO:0008289 ! lipid binding [Term] id: GO:0046629 name: gamma-delta T cell activation is_a: GO:0042110 ! T cell activation [Term] id: GO:0046631 name: alpha-beta T cell activation is_a: GO:0042110 ! T cell activation [Term] id: GO:0046634 name: regulation of alpha-beta T cell activation is_a: GO:0050863 ! regulation of T cell activation [Term] id: GO:0046635 name: positive regulation of alpha-beta T cell activation is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0046637 name: regulation of alpha-beta T cell differentiation is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046634 ! regulation of alpha-beta T cell activation [Term] id: GO:0046638 name: positive regulation of alpha-beta T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation [Term] id: GO:0046649 name: lymphocyte activation is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0046651 name: lymphocyte proliferation is_a: GO:0032943 ! mononuclear cell proliferation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0046717 name: acid secretion is_a: GO:0046903 ! secretion [Term] id: GO:0046864 name: isoprenoid transport is_a: GO:0006869 ! lipid transport [Term] id: GO:0046865 name: terpenoid transport is_a: GO:0046864 ! isoprenoid transport [Term] id: GO:0046879 name: hormone secretion is_a: GO:0008150 ! biological_process is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release [Term] id: GO:0046903 name: secretion is_a: GO:0044765 ! single-organism transport [Term] id: GO:0046942 name: carboxylic acid transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0048002 name: antigen processing and presentation of peptide antigen is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0048103 name: somatic stem cell division is_a: GO:0017145 ! stem cell division [Term] id: GO:0048137 name: spermatocyte division is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051301 ! cell division [Term] id: GO:0048232 name: male gamete generation is_a: GO:0007276 ! gamete generation [Term] id: GO:0048240 name: sperm capacitation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048469 ! cell maturation [Term] id: GO:0048241 name: epinephrine transport is_a: GO:0009914 ! hormone transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0048242 name: epinephrine secretion is_a: GO:0046879 ! hormone secretion is_a: GO:0048241 ! epinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048243 name: norepinephrine secretion is_a: GO:0015874 ! norepinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048285 name: organelle fission is_a: GO:0006996 ! organelle organization [Term] id: GO:0048293 name: regulation of isotype switching to IgE isotypes is_a: GO:0045191 ! regulation of isotype switching [Term] id: GO:0048295 name: positive regulation of isotype switching to IgE isotypes is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes [Term] id: GO:0048468 name: cell development is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0048469 name: cell maturation is_a: GO:0021700 ! developmental maturation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0048477 name: oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation [Term] id: GO:0048511 name: rhythmic process is_a: GO:0008150 ! biological_process [Term] id: GO:0048518 name: positive regulation of biological process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0048519 name: negative regulation of biological process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0048520 name: positive regulation of behavior is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior [Term] id: GO:0048522 name: positive regulation of cellular process is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0048523 name: negative regulation of cellular process is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0048583 name: regulation of response to stimulus is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0048584 name: positive regulation of response to stimulus is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0048609 name: multicellular organismal reproductive process is_a: GO:0022414 ! reproductive process [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis is_a: GO:0032502 ! developmental process [Term] id: GO:0048770 name: pigment granule is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0048771 name: tissue remodeling is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0048856 name: anatomical structure development is_a: GO:0032502 ! developmental process [Term] id: GO:0048869 name: cellular developmental process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0048870 name: cell motility is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0040011 ! locomotion [Term] id: GO:0048875 name: chemical homeostasis within a tissue is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0048878 name: chemical homeostasis is_a: GO:0042592 ! homeostatic process [Term] id: GO:0050432 name: catecholamine secretion is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0050670 name: regulation of lymphocyte proliferation is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0050672 name: negative regulation of lymphocyte proliferation is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051250 ! negative regulation of lymphocyte activation [Term] id: GO:0050678 name: regulation of epithelial cell proliferation is_a: GO:0042127 ! regulation of cell proliferation [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation [Term] id: GO:0050708 name: regulation of protein secretion is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell [Term] id: GO:0050714 name: positive regulation of protein secretion is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell [Term] id: GO:0050727 name: regulation of inflammatory response is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:1903034 ! regulation of response to wounding [Term] id: GO:0050728 name: negative regulation of inflammatory response is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:1903035 ! negative regulation of response to wounding [Term] id: GO:0050729 name: positive regulation of inflammatory response is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:1903036 ! positive regulation of response to wounding [Term] id: GO:0050776 name: regulation of immune response is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0050777 name: negative regulation of immune response is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0050778 name: positive regulation of immune response is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0050789 name: regulation of biological process is_a: GO:0065007 ! biological regulation [Term] id: GO:0050793 name: regulation of developmental process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0050794 name: regulation of cellular process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0050795 name: regulation of behavior is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0050817 name: coagulation is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0050863 name: regulation of T cell activation is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion [Term] id: GO:0050864 name: regulation of B cell activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0050865 name: regulation of cell activation is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0050866 name: negative regulation of cell activation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation [Term] id: GO:0050867 name: positive regulation of cell activation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation [Term] id: GO:0050868 name: negative regulation of T cell activation is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion [Term] id: GO:0050870 name: positive regulation of T cell activation is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion [Term] id: GO:0050871 name: positive regulation of B cell activation is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0050877 name: neurological system process is_a: GO:0003008 ! system process [Term] id: GO:0050878 name: regulation of body fluid levels is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050896 name: response to stimulus is_a: GO:0008150 ! biological_process [Term] id: GO:0050900 name: leukocyte migration is_a: GO:0002376 ! immune system process is_a: GO:0016477 ! cell migration [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception is_a: GO:0009584 ! detection of visible light is_a: GO:0050962 ! detection of light stimulus involved in sensory perception [Term] id: GO:0050910 name: detection of mechanical stimulus involved in sensory perception of sound is_a: GO:0050877 ! neurological system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception [Term] id: GO:0050911 name: detection of chemical stimulus involved in sensory perception of smell is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception [Term] id: GO:0050912 name: detection of chemical stimulus involved in sensory perception of taste is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception [Term] id: GO:0050920 name: regulation of chemotaxis is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior [Term] id: GO:0050921 name: positive regulation of chemotaxis is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0050920 ! regulation of chemotaxis [Term] id: GO:0050960 name: detection of temperature stimulus involved in thermoception is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception [Term] id: GO:0050961 name: detection of temperature stimulus involved in sensory perception is_a: GO:0016048 ! detection of temperature stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: GO:0050974 name: detection of mechanical stimulus involved in sensory perception is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050982 ! detection of mechanical stimulus [Term] id: GO:0050976 name: detection of mechanical stimulus involved in sensory perception of touch is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception [Term] id: GO:0050982 name: detection of mechanical stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0051023 name: regulation of immunoglobulin secretion is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0050708 ! regulation of protein secretion [Term] id: GO:0051024 name: positive regulation of immunoglobulin secretion is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0051023 ! regulation of immunoglobulin secretion [Term] id: GO:0051046 name: regulation of secretion is_a: GO:0051049 ! regulation of transport [Term] id: GO:0051047 name: positive regulation of secretion is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport [Term] id: GO:0051049 name: regulation of transport is_a: GO:0032879 ! regulation of localization [Term] id: GO:0051050 name: positive regulation of transport is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport [Term] id: GO:0051052 name: regulation of DNA metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process [Term] id: GO:0051093 name: negative regulation of developmental process is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0051094 name: positive regulation of developmental process is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0051132 name: NK T cell activation is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0051146 name: striated muscle cell differentiation is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process is_a: GO:0019222 ! regulation of metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process [Term] id: GO:0051179 name: localization is_a: GO:0008150 ! biological_process [Term] id: GO:0051222 name: positive regulation of protein transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport [Term] id: GO:0051223 name: regulation of protein transport is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization [Term] id: GO:0051234 name: establishment of localization is_a: GO:0051179 ! localization [Term] id: GO:0051239 name: regulation of multicellular organismal process is_a: GO:0050789 ! regulation of biological process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:0051249 name: regulation of lymphocyte activation is_a: GO:0002694 ! regulation of leukocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation [Term] id: GO:0051270 name: regulation of cellular component movement is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0051272 name: positive regulation of cellular component movement is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement [Term] id: GO:0051276 name: chromosome organization is_a: GO:0006996 ! organelle organization [Term] id: GO:0051301 name: cell division is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0051458 name: corticotropin secretion is_a: GO:0030072 ! peptide hormone secretion is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0051606 name: detection of stimulus is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051608 name: histamine transport is_a: GO:0006812 ! cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0045117 ! azole transport [Term] id: GO:0051641 name: cellular localization is_a: GO:0051179 ! localization [Term] id: GO:0051649 name: establishment of localization in cell is_a: GO:0051234 ! establishment of localization [Term] id: GO:0051704 name: multi-organism process is_a: GO:0008150 ! biological_process [Term] id: GO:0051707 name: response to other organism is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051767 name: nitric-oxide synthase biosynthetic process is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051861 name: glycolipid binding is_a: GO:0008289 ! lipid binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0051937 name: catecholamine transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0055007 name: cardiac muscle cell differentiation is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0060047 name: heart contraction is_a: GO:0003015 ! heart process [Term] id: GO:0060054 name: positive regulation of epithelial cell proliferation involved in wound healing is_a: GO:0050679 ! positive regulation of epithelial cell proliferation [Term] id: GO:0060089 name: molecular transducer activity is_a: GO:0003674 ! molecular_function [Term] id: GO:0060096 name: serotonin secretion, neurotransmission is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0060249 name: anatomical structure homeostasis is_a: GO:0042592 ! homeostatic process [Term] id: GO:0060255 name: regulation of macromolecule metabolic process is_a: GO:0019222 ! regulation of metabolic process [Term] id: GO:0060326 name: cell chemotaxis is_a: GO:0006935 ! chemotaxis is_a: GO:0016477 ! cell migration [Term] id: GO:0060341 name: regulation of cellular localization is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0060374 name: mast cell differentiation is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0060591 name: chondroblast differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0060986 name: endocrine hormone secretion is_a: GO:0046879 ! hormone secretion [Term] id: GO:0061526 name: acetylcholine secretion is_a: GO:0015870 ! acetylcholine transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0061527 name: dopamine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014046 ! dopamine secretion [Term] id: GO:0061528 name: aspartate secretion is_a: GO:0015810 ! aspartate transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0061529 name: epinephrine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0048242 ! epinephrine secretion [Term] id: GO:0061530 name: aspartate secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061528 ! aspartate secretion [Term] id: GO:0061533 name: norepinephrine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0048243 ! norepinephrine secretion [Term] id: GO:0061534 name: gamma-aminobutyric acid secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0061535 name: glutamate secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014047 ! glutamate secretion [Term] id: GO:0061536 name: glycine secretion is_a: GO:0015816 ! glycine transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0061537 name: glycine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061536 ! glycine secretion [Term] id: GO:0061538 name: histamine secretion, neurotransmission is_a: GO:0001821 ! histamine secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0061539 name: octopamine secretion is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0032940 ! secretion by cell is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0061540 name: octopamine secretion, neurotransmission is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061539 ! octopamine secretion [Term] id: GO:0061544 name: peptide secretion, neurotransmission is_a: GO:0002790 ! peptide secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0061584 name: hypocretin secretion is_a: GO:0002790 ! peptide secretion [Term] id: GO:0061585 name: hypocretin secretion, neurotransmission is_a: GO:0061544 ! peptide secretion, neurotransmission is_a: GO:0061584 ! hypocretin secretion [Term] id: GO:0065007 name: biological regulation is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality is_a: GO:0065007 ! biological regulation [Term] id: GO:0070091 name: glucagon secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070201 name: regulation of establishment of protein localization is_a: GO:0032880 ! regulation of protein localization [Term] id: GO:0070228 name: regulation of lymphocyte apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process [Term] id: GO:0070253 name: somatostatin secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070254 name: mucus secretion is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0070278 name: extracellular matrix constituent secretion is_a: GO:0032940 ! secretion by cell [Term] id: GO:0070459 name: prolactin secretion is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070460 name: thyroid-stimulating hormone secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070486 name: leukocyte aggregation is_a: GO:0007159 ! leukocyte cell-cell adhesion is_a: GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0070489 name: T cell aggregation is_a: GO:0045321 ! leukocyte activation is_a: GO:0071593 ! lymphocyte aggregation [Term] id: GO:0070661 name: leukocyte proliferation is_a: GO:0008283 ! cell proliferation [Term] id: GO:0070663 name: regulation of leukocyte proliferation is_a: GO:0042127 ! regulation of cell proliferation [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation [Term] id: GO:0070727 name: cellular macromolecule localization is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization [Term] id: GO:0070820 name: tertiary granule is_a: GO:0030141 ! secretory granule [Term] id: GO:0070925 name: organelle assembly is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0070999 name: detection of mechanical stimulus involved in sensory perception of gravity is_a: GO:0009590 ! detection of gravity is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception [Term] id: GO:0071103 name: DNA conformation change is_a: GO:0051276 ! chromosome organization [Term] id: GO:0071593 name: lymphocyte aggregation is_a: GO:0070486 ! leukocyte aggregation [Term] id: GO:0071622 name: regulation of granulocyte chemotaxis is_a: GO:0002688 ! regulation of leukocyte chemotaxis [Term] id: GO:0071624 name: positive regulation of granulocyte chemotaxis is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis [Term] id: GO:0071702 name: organic substance transport is_a: GO:0006810 ! transport [Term] id: GO:0071704 name: organic substance metabolic process is_a: GO:0008152 ! metabolic process [Term] id: GO:0071705 name: nitrogen compound transport is_a: GO:0006810 ! transport [Term] id: GO:0071706 name: tumor necrosis factor superfamily cytokine production is_a: GO:0001816 ! cytokine production [Term] id: GO:0071707 name: immunoglobulin heavy chain V-D-J recombination is_a: GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: GO:0071708 name: immunoglobulin light chain V-J recombination is_a: GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: GO:0071735 name: IgG immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071736 name: IgG immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071735 ! IgG immunoglobulin complex [Term] id: GO:0071738 name: IgD immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071739 name: IgD immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071738 ! IgD immunoglobulin complex [Term] id: GO:0071742 name: IgE immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071743 name: IgE immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071742 ! IgE immunoglobulin complex [Term] id: GO:0071745 name: IgA immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071746 name: IgA immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071745 ! IgA immunoglobulin complex [Term] id: GO:0071753 name: IgM immunoglobulin complex is_a: GO:0019814 ! immunoglobulin complex [Term] id: GO:0071754 name: IgM immunoglobulin complex, circulating is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071753 ! IgM immunoglobulin complex [Term] id: GO:0071840 name: cellular component organization or biogenesis is_a: GO:0008150 ! biological_process [Term] id: GO:0071912 name: asynchronous neurotransmitter secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0071941 name: nitrogen cycle metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0071971 name: extracellular exosome assembly is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0072593 name: reactive oxygen species metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0080090 name: regulation of primary metabolic process is_a: GO:0019222 ! regulation of metabolic process [Term] id: GO:0080134 name: regulation of response to stress is_a: GO:0048583 ! regulation of response to stimulus [Term] id: GO:0090022 name: regulation of neutrophil chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:1902622 ! regulation of neutrophil migration [Term] id: GO:0090023 name: positive regulation of neutrophil chemotaxis is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis is_a: GO:1902624 ! positive regulation of neutrophil migration [Term] id: GO:0090257 name: regulation of muscle system process is_a: GO:0044057 ! regulation of system process [Term] id: GO:0090304 name: nucleic acid metabolic process is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0097028 name: dendritic cell differentiation is_a: GO:0002521 ! leukocyte differentiation [Term] id: GO:0097186 name: amelogenesis is_a: GO:0042475 ! odontogenesis of dentin-containing tooth is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0097367 name: carbohydrate derivative binding is_a: GO:0005488 ! binding [Term] id: GO:0097529 name: myeloid leukocyte migration is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0098542 name: defense response to other organism is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism [Term] id: GO:0098588 name: bounding membrane of organelle is_a: GO:0031090 ! organelle membrane [Term] id: GO:0098602 name: single organism cell adhesion is_a: GO:0007155 ! cell adhesion is_a: GO:0044699 ! single-organism process [Term] id: GO:0098609 name: cell-cell adhesion is_a: GO:0007155 ! cell adhesion [Term] id: GO:0098754 name: detoxification is_a: GO:0008152 ! metabolic process [Term] id: GO:0098796 name: membrane protein complex is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part [Term] id: GO:0098797 name: plasma membrane protein complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0098802 name: plasma membrane receptor complex is_a: GO:0043235 ! receptor complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0098805 name: whole membrane is_a: GO:0016020 ! membrane [Term] id: GO:1901135 name: carbohydrate derivative metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:1901342 name: regulation of vasculature development is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:1901360 name: organic cyclic compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:1901374 name: acetate ester transport is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:1901564 name: organonitrogen compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:1901576 name: organic substance biosynthetic process is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901615 name: organic hydroxy compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:1901617 name: organic hydroxy compound biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:1901618 name: organic hydroxy compound transmembrane transporter activity is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:1902105 name: regulation of leukocyte differentiation is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1903706 ! regulation of hemopoiesis [Term] id: GO:1902107 name: positive regulation of leukocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis [Term] id: GO:1902578 name: single-organism localization is_a: GO:0044699 ! single-organism process is_a: GO:0051179 ! localization [Term] id: GO:1902589 name: single-organism organelle organization is_a: GO:0006996 ! organelle organization is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:1902622 name: regulation of neutrophil migration is_a: GO:0002685 ! regulation of leukocyte migration [Term] id: GO:1902624 name: positive regulation of neutrophil migration is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:1902622 ! regulation of neutrophil migration [Term] id: GO:1903034 name: regulation of response to wounding is_a: GO:0080134 ! regulation of response to stress [Term] id: GO:1903035 name: negative regulation of response to wounding is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding [Term] id: GO:1903036 name: positive regulation of response to wounding is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding [Term] id: GO:1903037 name: regulation of leukocyte cell-cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion [Term] id: GO:1903038 name: negative regulation of leukocyte cell-cell adhesion is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion [Term] id: GO:1903039 name: positive regulation of leukocyte cell-cell adhesion is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion [Term] id: GO:1903046 name: meiotic cell cycle process is_a: GO:0022402 ! cell cycle process [Term] id: GO:1903047 name: mitotic cell cycle process is_a: GO:0022402 ! cell cycle process [Term] id: GO:1903510 name: mucopolysaccharide metabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:1903530 name: regulation of secretion by cell is_a: GO:0051046 ! regulation of secretion is_a: GO:0060341 ! regulation of cellular localization [Term] id: GO:1903532 name: positive regulation of secretion by cell is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell [Term] id: GO:1903706 name: regulation of hemopoiesis is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:1903708 name: positive regulation of hemopoiesis is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis [Term] id: GO:1904018 name: positive regulation of vasculature development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development [Term] id: GO:2000026 name: regulation of multicellular organismal development is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process [Term] id: GO:2000027 name: regulation of organ morphogenesis is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process is_a: GO:0042981 ! regulation of apoptotic process [Term] id: GO:2000145 name: regulation of cell motility is_a: GO:0040012 ! regulation of locomotion is_a: GO:0051270 ! regulation of cellular component movement [Term] id: GO:2000147 name: positive regulation of cell motility is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility [Term] id: GO:2000514 name: regulation of CD4-positive, alpha-beta T cell activation is_a: GO:0046634 ! regulation of alpha-beta T cell activation [Term] id: GO:2000516 name: positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation [Term] id: NCBITaxon:1 name: root synonym: "all" RELATED [] [Term] id: NCBITaxon:10066 name: Muridae is_a: NCBITaxon:337687 ! Muroidea [Term] id: NCBITaxon:10088 name: Mus synonym: "mice" EXACT [] synonym: "Mus" EXACT [] is_a: NCBITaxon:39107 ! Murinae [Term] id: NCBITaxon:10090 name: Mus musculus synonym: "house mouse" EXACT [] synonym: "mice C57BL/6xCBA/CaJ hybrid" RELATED [] synonym: "mouse" EXACT [] synonym: "Mus muscaris" RELATED [] is_a: NCBITaxon:862507 ! Mus [Term] id: NCBITaxon:10114 name: Rattus synonym: "rat" EXACT [] synonym: "rats" EXACT [] is_a: NCBITaxon:39107 ! Murinae [Term] id: NCBITaxon:10116 name: Rattus norvegicus synonym: "brown rat" EXACT [] synonym: "Gunn rats" RELATED [] synonym: "Norway rat" EXACT [] synonym: "rat" EXACT [] synonym: "rats" EXACT [] synonym: "Rattus norvegicus8" RELATED [] synonym: "Rattus norwegicus" RELATED [] synonym: "Rattus rattiscus" RELATED [] synonym: "Rattus sp. strain Wistar" EXACT [] is_a: NCBITaxon:10114 ! Rattus [Term] id: NCBITaxon:10219 name: Hemichordata synonym: "hemichordates" EXACT [] synonym: "hemichordates" RELATED [] is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:104431 name: Obtectomera is_a: NCBITaxon:37567 ! Ditrysia [Term] id: NCBITaxon:105389 name: Palpata is_a: NCBITaxon:6341 ! Polychaeta [Term] id: NCBITaxon:105390 name: Aciculata is_a: NCBITaxon:105389 ! Palpata [Term] id: NCBITaxon:105391 name: Canalipalpata is_a: NCBITaxon:105389 ! Palpata [Term] id: NCBITaxon:110551 name: Myxininae is_a: NCBITaxon:7762 ! Myxinidae [Term] id: NCBITaxon:110555 name: Myxine is_a: NCBITaxon:110551 ! Myxininae [Term] id: NCBITaxon:110814 name: Xenoturbellida is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:110815 name: Xenoturbella is_a: NCBITaxon:110814 ! Xenoturbellida [Term] id: NCBITaxon:117565 name: Hyperotreti synonym: "Agnatha" RELATED [] synonym: "fish" EXACT [] synonym: "fishes" EXACT [] is_a: NCBITaxon:1476529 ! Cyclostomata [Term] id: NCBITaxon:117569 name: Hyperoartia synonym: "Agnatha" RELATED [] synonym: "Cephalaspidomorphi" RELATED [] synonym: "fish" EXACT [] synonym: "fishes" EXACT [] synonym: "Monorhina" RELATED [] is_a: NCBITaxon:1476529 ! Cyclostomata [Term] id: NCBITaxon:117570 name: Teleostomi is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:117571 name: Euteleostomi synonym: "bony vertebrates" EXACT [] is_a: NCBITaxon:117570 ! Teleostomi [Term] id: NCBITaxon:117893 name: Batoidea synonym: "rays" EXACT [] is_a: NCBITaxon:7778 ! Elasmobranchii [Term] id: NCBITaxon:118072 name: Coelacanthimorpha synonym: "Actinistia" RELATED [] synonym: "Choanichthyes" RELATED [] synonym: "Crossopterygii" RELATED [] synonym: "fish" EXACT [] synonym: "fishes" EXACT [] synonym: "lobe-finned fishes" EXACT [] is_a: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:119089 name: Chromadorea synonym: "Adenophorea" RELATED [] is_a: NCBITaxon:6231 ! Nematoda [Term] id: NCBITaxon:1206794 name: Ecdysozoa is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:1206795 name: Lophotrochozoa is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:123365 name: Neoteleostei is_a: NCBITaxon:1489388 ! Euteleosteomorpha [Term] id: NCBITaxon:123366 name: Eurypterygia synonym: "Eurypterygii" RELATED [] is_a: NCBITaxon:123365 ! Neoteleostei [Term] id: NCBITaxon:123367 name: Ctenosquamata is_a: NCBITaxon:123366 ! Eurypterygia [Term] id: NCBITaxon:123368 name: Acanthomorphata synonym: "Acanthomorpha" RELATED [] is_a: NCBITaxon:123367 ! Ctenosquamata [Term] id: NCBITaxon:123369 name: Euacanthomorphacea synonym: "Euacanthomorpha" RELATED [] is_a: NCBITaxon:123368 ! Acanthomorphata [Term] id: NCBITaxon:126287 name: Didelphinae is_a: NCBITaxon:9265 ! Didelphidae [Term] id: NCBITaxon:1294634 name: Crocodylia synonym: "Crocodilia" RELATED [] synonym: "reptiles" RELATED [] synonym: "Reptilia" RELATED [] is_a: NCBITaxon:8492 ! Archosauria [Term] id: NCBITaxon:1298654 name: Longirostres is_a: NCBITaxon:1294634 ! Crocodylia [Term] id: NCBITaxon:1312402 name: Xenacoelomorpha is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:131567 name: cellular organisms synonym: "biota" RELATED [] is_a: NCBITaxon:1 ! root [Term] id: NCBITaxon:1329799 name: Testudines + Archosauria group synonym: "Archosauria-Testudines" RELATED [] is_a: NCBITaxon:32561 ! Sauria [Term] id: NCBITaxon:1329911 name: Toxicofera is_a: NCBITaxon:1329912 ! Episquamata [Term] id: NCBITaxon:1329912 name: Episquamata is_a: NCBITaxon:1329950 ! Unidentata [Term] id: NCBITaxon:1329950 name: Unidentata is_a: NCBITaxon:1329961 ! Bifurcata [Term] id: NCBITaxon:1329961 name: Bifurcata synonym: "split-tongued squamates" EXACT [] is_a: NCBITaxon:8509 ! Squamata [Term] id: NCBITaxon:133551 name: Eleutherozoa is_a: NCBITaxon:7586 ! Echinodermata [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha is_a: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:13615 name: Monodelphis synonym: "short-tailed opossums" EXACT [] is_a: NCBITaxon:126287 ! Didelphinae [Term] id: NCBITaxon:13616 name: Monodelphis domestica synonym: "gray short-tailed opossum" EXACT [] synonym: "Monodelphis domesticus" RELATED [] is_a: NCBITaxon:13615 ! Monodelphis [Term] id: NCBITaxon:1437010 name: Boreoeutheria synonym: "Boreotheria" RELATED [] is_a: NCBITaxon:9347 ! Eutheria [Term] id: NCBITaxon:147099 name: Acoelomorpha is_a: NCBITaxon:1312402 ! Xenacoelomorpha [Term] id: NCBITaxon:1476529 name: Cyclostomata synonym: "Agnatha" RELATED [] synonym: "jawless vertebrates" EXACT [] is_a: NCBITaxon:7742 ! Vertebrata [Term] id: NCBITaxon:1489340 name: Elopocephalai is_a: NCBITaxon:32443 ! Teleostei [Term] id: NCBITaxon:1489341 name: Osteoglossocephalai is_a: NCBITaxon:32443 ! Teleostei [Term] id: NCBITaxon:1489343 name: Osteoglossocephala is_a: NCBITaxon:1489341 ! Osteoglossocephalai [Term] id: NCBITaxon:1489388 name: Euteleosteomorpha is_a: NCBITaxon:186625 ! Clupeocephala [Term] id: NCBITaxon:1489872 name: Percomorphaceae is_a: NCBITaxon:123369 ! Euacanthomorphacea [Term] id: NCBITaxon:1489873 name: Ophidiimorpharia is_a: NCBITaxon:1489872 ! Percomorphaceae [Term] id: NCBITaxon:1489908 name: Ovalentaria synonym: "Stiassnyiformes" RELATED [] is_a: NCBITaxon:1489872 ! Percomorphaceae [Term] id: NCBITaxon:1489913 name: Atherinomorphae synonym: "Atherinomorpha" RELATED [] is_a: NCBITaxon:1489908 ! Ovalentaria [Term] id: NCBITaxon:1489922 name: Percomorpharia is_a: NCBITaxon:1489872 ! Percomorphaceae [Term] id: NCBITaxon:181400 name: Bythitoidei is_a: NCBITaxon:94929 ! Ophidiiformes [Term] id: NCBITaxon:182222 name: Muraeninae is_a: NCBITaxon:46660 ! Muraenidae [Term] id: NCBITaxon:186285 name: Drosophiliti is_a: NCBITaxon:46879 ! Drosophilina [Term] id: NCBITaxon:186623 name: Actinopteri is_a: NCBITaxon:7898 ! Actinopterygii [Term] id: NCBITaxon:186624 name: Elopocephala is_a: NCBITaxon:1489340 ! Elopocephalai [Term] id: NCBITaxon:186625 name: Clupeocephala is_a: NCBITaxon:1489341 ! Osteoglossocephalai [Term] id: NCBITaxon:186626 name: Otophysa synonym: "Otophysi" RELATED [] is_a: NCBITaxon:32519 ! Ostariophysi [Term] id: NCBITaxon:186627 name: Cypriniphysae synonym: "Cypriniphysi" RELATED [] is_a: NCBITaxon:186626 ! Otophysa [Term] id: NCBITaxon:186634 name: Otomorpha synonym: "Ostarioclupeomorpha" RELATED [] synonym: "Otocephala" RELATED [] is_a: NCBITaxon:186625 ! Clupeocephala [Term] id: NCBITaxon:189497 name: Echidna is_a: NCBITaxon:182222 ! Muraeninae [Term] id: NCBITaxon:197562 name: Pancrustacea is_a: NCBITaxon:197563 ! Mandibulata [Term] id: NCBITaxon:197563 name: Mandibulata synonym: "mandibulates" EXACT [] is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:207598 name: Homininae synonym: "Homo/Pan/Gorilla group" RELATED [] is_a: NCBITaxon:9604 ! Hominidae [Term] id: NCBITaxon:262014 name: Xenopus synonym: "Xenopus" EXACT [] is_a: NCBITaxon:8353 ! Xenopus [Term] id: NCBITaxon:2759 name: Eukaryota synonym: "Eucarya" RELATED [] synonym: "Eucaryotae" RELATED [] synonym: "eucaryotes" EXACT [] synonym: "Eukarya" RELATED [] synonym: "Eukaryotae" RELATED [] synonym: "eukaryotes" EXACT [] synonym: "eukaryotes" RELATED [] is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:27592 name: Bovinae is_a: NCBITaxon:9895 ! Bovidae [Term] id: NCBITaxon:28376 name: Anolis synonym: "Norops" RELATED [] is_a: NCBITaxon:81957 ! Polychrotinae [Term] id: NCBITaxon:28377 name: Anolis carolinensis synonym: "Carolina anole" EXACT [] synonym: "green anole" EXACT [] is_a: NCBITaxon:28376 ! Anolis [Term] id: NCBITaxon:28781 name: Adrianichthyoidei is_a: NCBITaxon:76071 ! Beloniformes [Term] id: NCBITaxon:30319 name: Pipoidea is_a: NCBITaxon:8342 ! Anura [Term] id: NCBITaxon:30458 name: Strigiformes synonym: "owls" EXACT [] is_a: NCBITaxon:8825 ! Neognathae [Term] id: NCBITaxon:30577 name: Erinaceinae synonym: "spiny hedgehogs" EXACT [] is_a: NCBITaxon:9363 ! Erinaceidae [Term] id: NCBITaxon:30648 name: Dipodidae synonym: "jerboas" EXACT [] is_a: NCBITaxon:33553 ! Sciurognathi [Term] id: NCBITaxon:30727 name: Cyprinoidea synonym: "Cyprinoidei" RELATED [] is_a: NCBITaxon:7952 ! Cypriniformes [Term] id: NCBITaxon:31022 name: Tetraodontiformes is_a: NCBITaxon:1489922 ! Percomorpharia [Term] id: NCBITaxon:31028 name: Tetraodontoidei is_a: NCBITaxon:31022 ! Tetraodontiformes [Term] id: NCBITaxon:31031 name: Tetraodontidae synonym: "puffer fishes" EXACT [] synonym: "puffers" EXACT [] is_a: NCBITaxon:32517 ! Tetradontoidea [Term] id: NCBITaxon:31032 name: Takifugu synonym: "Fugu" RELATED [] is_a: NCBITaxon:31031 ! Tetraodontidae [Term] id: NCBITaxon:31033 name: Takifugu rubripes synonym: "Fugu rubripes" RELATED [] synonym: "Sphaeroides rubripes" RELATED [] synonym: "Takifugu rubripes (Temminck & Schlegel, 1850)" RELATED [] synonym: "Tetraodon rubripes" RELATED [] synonym: "tiger puffer" EXACT [] synonym: "torafugu" EXACT [] is_a: NCBITaxon:31032 ! Takifugu [Term] id: NCBITaxon:31089 name: Osteoglossomorpha is_a: NCBITaxon:1489343 ! Osteoglossocephala [Term] id: NCBITaxon:311790 name: Afrotheria is_a: NCBITaxon:9347 ! Eutheria [Term] id: NCBITaxon:314145 name: Laurasiatheria is_a: NCBITaxon:1437010 ! Boreoeutheria [Term] id: NCBITaxon:314146 name: Euarchontoglires is_a: NCBITaxon:1437010 ! Boreoeutheria [Term] id: NCBITaxon:314147 name: Glires synonym: "Rodents and rabbits" EXACT [] is_a: NCBITaxon:314146 ! Euarchontoglires [Term] id: NCBITaxon:314293 name: Simiiformes synonym: "Anthropoidea" RELATED [] is_a: NCBITaxon:376913 ! Haplorrhini [Term] id: NCBITaxon:314294 name: Cercopithecoidea is_a: NCBITaxon:9526 ! Catarrhini [Term] id: NCBITaxon:314295 name: Hominoidea synonym: "ape" EXACT [] synonym: "apes" EXACT [] is_a: NCBITaxon:9526 ! Catarrhini [Term] id: NCBITaxon:32341 name: Sophophora is_a: NCBITaxon:7215 ! Drosophila [Term] id: NCBITaxon:32346 name: melanogaster group is_a: NCBITaxon:32341 ! Sophophora [Term] id: NCBITaxon:32351 name: melanogaster subgroup is_a: NCBITaxon:32346 ! melanogaster group [Term] id: NCBITaxon:32443 name: Teleostei synonym: "teleost fishes" EXACT [] is_a: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32517 name: Tetradontoidea is_a: NCBITaxon:31028 ! Tetraodontoidei [Term] id: NCBITaxon:32519 name: Ostariophysi is_a: NCBITaxon:186634 ! Otomorpha [Term] id: NCBITaxon:32521 name: Elopomorpha is_a: NCBITaxon:186624 ! Elopocephala [Term] id: NCBITaxon:32523 name: Tetrapoda synonym: "tetrapods" EXACT [] is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] id: NCBITaxon:32524 name: Amniota synonym: "amniotes" EXACT [] is_a: NCBITaxon:32523 ! Tetrapoda [Term] id: NCBITaxon:32525 name: Theria synonym: "Theria" EXACT [] is_a: NCBITaxon:40674 ! Mammalia [Term] id: NCBITaxon:32561 name: Sauria synonym: "Diapsida" RELATED [] synonym: "diapsids" EXACT [] is_a: NCBITaxon:8457 ! Sauropsida [Term] id: NCBITaxon:33154 name: Opisthokonta synonym: "Fungi/Metazoa group" RELATED [] synonym: "opisthokonts" RELATED [] is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:33208 name: Metazoa synonym: "Animalia" RELATED [] synonym: "animals" RELATED [] synonym: "metazoans" EXACT [] synonym: "multicellular animals" EXACT [] is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:33213 name: Bilateria is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:33317 name: Protostomia is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:33340 name: Neoptera is_a: NCBITaxon:7496 ! Pterygota [Term] id: NCBITaxon:33392 name: Endopterygota synonym: "Holometabola" RELATED [] is_a: NCBITaxon:33340 ! Neoptera [Term] id: NCBITaxon:33511 name: Deuterostomia synonym: "deuterostomes" EXACT [] is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:33553 name: Sciurognathi is_a: NCBITaxon:9989 ! Rodentia [Term] id: NCBITaxon:33554 name: Carnivora synonym: "carnivores" EXACT [] synonym: "carnivores" RELATED [] is_a: NCBITaxon:314145 ! Laurasiatheria [Term] id: NCBITaxon:337687 name: Muroidea is_a: NCBITaxon:33553 ! Sciurognathi [Term] id: NCBITaxon:34989 name: Colubroidea synonym: "Xenophidia" RELATED [] is_a: NCBITaxon:8570 ! Serpentes [Term] id: NCBITaxon:35497 name: Suina synonym: "Artiodactyla" RELATED [] synonym: "Suiformes" RELATED [] is_a: NCBITaxon:91561 ! Cetartiodactyla [Term] id: NCBITaxon:35500 name: Pecora is_a: NCBITaxon:9845 ! Ruminantia [Term] id: NCBITaxon:35737 name: Dipodinae is_a: NCBITaxon:30648 ! Dipodidae [Term] id: NCBITaxon:37512 name: Ceriantharia synonym: "tube anemones" RELATED [] synonym: "tube-dwelling anemones" EXACT [] is_a: NCBITaxon:6102 ! Hexacorallia [Term] id: NCBITaxon:37567 name: Ditrysia is_a: NCBITaxon:41197 ! Heteroneura [Term] id: NCBITaxon:37572 name: Papilionoidea synonym: "butterflies" EXACT [] synonym: "butterflies" RELATED [] is_a: NCBITaxon:104431 ! Obtectomera [Term] id: NCBITaxon:376912 name: Tarsiiformes is_a: NCBITaxon:376913 ! Haplorrhini [Term] id: NCBITaxon:376913 name: Haplorrhini is_a: NCBITaxon:9443 ! Primates [Term] id: NCBITaxon:378855 name: Atelidae is_a: NCBITaxon:9479 ! Platyrrhini [Term] id: NCBITaxon:379583 name: Feliformia is_a: NCBITaxon:33554 ! Carnivora [Term] id: NCBITaxon:379584 name: Caniformia is_a: NCBITaxon:33554 ! Carnivora [Term] id: NCBITaxon:38066 name: Alouattinae is_a: NCBITaxon:378855 ! Atelidae [Term] id: NCBITaxon:38605 name: Didelphimorphia is_a: NCBITaxon:9263 ! Metatheria [Term] id: NCBITaxon:38609 name: Diprotodontia is_a: NCBITaxon:9263 ! Metatheria [Term] id: NCBITaxon:39107 name: Murinae is_a: NCBITaxon:10066 ! Muridae [Term] id: NCBITaxon:39820 name: Nereididae synonym: "Nereidae" RELATED [] synonym: "sandworms" EXACT [] is_a: NCBITaxon:6348 ! Phyllodocida [Term] id: NCBITaxon:40150 name: Monodon is_a: NCBITaxon:9747 ! Monodontidae [Term] id: NCBITaxon:40151 name: Monodon monoceros synonym: "narwhal" EXACT [] is_a: NCBITaxon:40150 ! Monodon [Term] id: NCBITaxon:40674 name: Mammalia synonym: "mammals" EXACT [] synonym: "mammals" RELATED [] is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:41191 name: Glossata is_a: NCBITaxon:7088 ! Lepidoptera [Term] id: NCBITaxon:41196 name: Neolepidoptera is_a: NCBITaxon:41191 ! Glossata [Term] id: NCBITaxon:41197 name: Heteroneura is_a: NCBITaxon:41196 ! Neolepidoptera [Term] id: NCBITaxon:41324 name: Siboglinidae synonym: "Frenulata" RELATED [] synonym: "Lamellibrachiidae" RELATED [] synonym: "Obturata" RELATED [] synonym: "Oligobrachiidae" RELATED [] synonym: "Perviata" RELATED [] synonym: "Pogonophora" RELATED [] synonym: "pogonophores" EXACT [] synonym: "Polybrachiidae" RELATED [] synonym: "Sclerolinidae" RELATED [] synonym: "tube worms" EXACT [] synonym: "tube worms" RELATED [] synonym: "Vestimentifera" RELATED [] synonym: "vestimentiferans" EXACT [] is_a: NCBITaxon:6362 ! Sabellida [Term] id: NCBITaxon:41665 name: Neopterygii synonym: "Neopterygi" RELATED [] is_a: NCBITaxon:186623 ! Actinopteri [Term] id: NCBITaxon:41666 name: Batrachia is_a: NCBITaxon:8292 ! Amphibia [Term] id: NCBITaxon:41712 name: Osteoglossiformes is_a: NCBITaxon:31089 ! Osteoglossomorpha [Term] id: NCBITaxon:43453 name: Caecilia is_a: NCBITaxon:8446 ! Caeciliidae [Term] id: NCBITaxon:436486 name: Dinosauria is_a: NCBITaxon:8492 ! Archosauria [Term] id: NCBITaxon:436489 name: Saurischia is_a: NCBITaxon:436486 ! Dinosauria [Term] id: NCBITaxon:436491 name: Theropoda is_a: NCBITaxon:436489 ! Saurischia [Term] id: NCBITaxon:436492 name: Coelurosauria is_a: NCBITaxon:436491 ! Theropoda [Term] id: NCBITaxon:43733 name: Muscomorpha synonym: "Asilomorpha" RELATED [] is_a: NCBITaxon:7203 ! Brachycera [Term] id: NCBITaxon:43738 name: Schizophora is_a: NCBITaxon:480117 ! Cyclorrhapha [Term] id: NCBITaxon:43741 name: Acalyptratae is_a: NCBITaxon:43738 ! Schizophora [Term] id: NCBITaxon:43746 name: Ephydroidea is_a: NCBITaxon:43741 ! Acalyptratae [Term] id: NCBITaxon:43845 name: Drosophilinae is_a: NCBITaxon:7214 ! Drosophilidae [Term] id: NCBITaxon:46660 name: Muraenidae synonym: "moray eels" EXACT [] is_a: NCBITaxon:7933 ! Anguilliformes [Term] id: NCBITaxon:46877 name: Drosophilini is_a: NCBITaxon:43845 ! Drosophilinae [Term] id: NCBITaxon:46879 name: Drosophilina is_a: NCBITaxon:46877 ! Drosophilini [Term] id: NCBITaxon:47144 name: Tetraodon is_a: NCBITaxon:31031 ! Tetraodontidae [Term] id: NCBITaxon:47757 name: Adrianichthyidae is_a: NCBITaxon:28781 ! Adrianichthyoidei [Term] id: NCBITaxon:480117 name: Cyclorrhapha is_a: NCBITaxon:480118 ! Eremoneura [Term] id: NCBITaxon:480118 name: Eremoneura is_a: NCBITaxon:43733 ! Muscomorpha [Term] id: NCBITaxon:48867 name: Jaculus is_a: NCBITaxon:35737 ! Dipodinae [Term] id: NCBITaxon:50557 name: Insecta synonym: "true insects" EXACT [] is_a: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:51337 name: Jaculus jaculus synonym: "lesser Egyptian jerboa" EXACT [] is_a: NCBITaxon:48867 ! Jaculus [Term] id: NCBITaxon:55879 name: Rhabditoidea is_a: NCBITaxon:6236 ! Rhabditida [Term] id: NCBITaxon:55885 name: Peloderinae is_a: NCBITaxon:6243 ! Rhabditidae [Term] id: NCBITaxon:6040 name: Porifera synonym: "Parazoa" RELATED [] synonym: "sponges" EXACT [] synonym: "sponges" RELATED [] is_a: NCBITaxon:33208 ! Metazoa [Term] id: NCBITaxon:6072 name: Eumetazoa is_a: NCBITaxon:33208 ! Metazoa [Term] id: NCBITaxon:6073 name: Cnidaria synonym: "cnidarians" EXACT [] synonym: "cnidarians" RELATED [] synonym: "Coelenterata" RELATED [] synonym: "coelenterates" EXACT [] is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:607660 name: Ponginae is_a: NCBITaxon:9604 ! Hominidae [Term] id: NCBITaxon:6101 name: Anthozoa synonym: "anthozoans" EXACT [] synonym: "anthozoans" RELATED [] is_a: NCBITaxon:6073 ! Cnidaria [Term] id: NCBITaxon:6102 name: Hexacorallia synonym: "Zoantharia" RELATED [] is_a: NCBITaxon:6101 ! Anthozoa [Term] id: NCBITaxon:6157 name: Platyhelminthes synonym: "flatworm" EXACT [] synonym: "flatworms" EXACT [] synonym: "flatworms" RELATED [] is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:6178 name: Trematoda is_a: NCBITaxon:6157 ! Platyhelminthes [Term] id: NCBITaxon:6199 name: Cestoda synonym: "tapeworms" EXACT [] is_a: NCBITaxon:6157 ! Platyhelminthes [Term] id: NCBITaxon:6200 name: Eucestoda is_a: NCBITaxon:6199 ! Cestoda [Term] id: NCBITaxon:6201 name: Cyclophyllidea is_a: NCBITaxon:6200 ! Eucestoda [Term] id: NCBITaxon:6208 name: Taeniidae is_a: NCBITaxon:6201 ! Cyclophyllidea [Term] id: NCBITaxon:6209 name: Echinococcus is_a: NCBITaxon:6208 ! Taeniidae [Term] id: NCBITaxon:6211 name: Echinococcus multilocularis is_a: NCBITaxon:6209 ! Echinococcus [Term] id: NCBITaxon:6217 name: Nemertea synonym: "bootlace worms" EXACT [] synonym: "nemertines" EXACT [] synonym: "Nemertini" RELATED [] synonym: "ribbon worms" EXACT [] synonym: "ribbon worms" RELATED [] is_a: NCBITaxon:1206795 ! Lophotrochozoa [Term] id: NCBITaxon:6231 name: Nematoda synonym: "Nemata" RELATED [] synonym: "nematode" EXACT [] synonym: "nematodes" EXACT [] synonym: "nematodes" RELATED [] synonym: "roundworm" EXACT [] synonym: "roundworms" EXACT [] is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:6236 name: Rhabditida is_a: NCBITaxon:119089 ! Chromadorea [Term] id: NCBITaxon:6237 name: Caenorhabditis is_a: NCBITaxon:55885 ! Peloderinae [Term] id: NCBITaxon:6239 name: Caenorhabditis elegans synonym: "Rhabditis elegans" RELATED [] synonym: "roundworm" EXACT [] is_a: NCBITaxon:6237 ! Caenorhabditis [Term] id: NCBITaxon:6243 name: Rhabditidae is_a: NCBITaxon:55879 ! Rhabditoidea [Term] id: NCBITaxon:6340 name: Annelida synonym: "annelid worms" EXACT [] synonym: "segmented worms" RELATED [] is_a: NCBITaxon:1206795 ! Lophotrochozoa [Term] id: NCBITaxon:6341 name: Polychaeta synonym: "polychaetes" EXACT [] is_a: NCBITaxon:6340 ! Annelida [Term] id: NCBITaxon:6348 name: Phyllodocida is_a: NCBITaxon:105390 ! Aciculata [Term] id: NCBITaxon:6358 name: Platynereis is_a: NCBITaxon:39820 ! Nereididae [Term] id: NCBITaxon:6362 name: Sabellida is_a: NCBITaxon:105391 ! Canalipalpata [Term] id: NCBITaxon:6425 name: Riftia is_a: NCBITaxon:41324 ! Siboglinidae [Term] id: NCBITaxon:6447 name: Mollusca synonym: "molluscs" EXACT [] synonym: "molluscs" RELATED [] synonym: "mollusks" EXACT [] is_a: NCBITaxon:1206795 ! Lophotrochozoa [Term] id: NCBITaxon:6448 name: Gastropoda synonym: "gastropods" EXACT [] synonym: "gastropods" RELATED [] is_a: NCBITaxon:6447 ! Mollusca [Term] id: NCBITaxon:6656 name: Arthropoda synonym: "arthropods" EXACT [] synonym: "arthropods" RELATED [] is_a: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6657 name: Crustacea synonym: "crustaceans" EXACT [] synonym: "crustaceans" RELATED [] is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:6830 name: Copepoda synonym: "copepods" EXACT [] is_a: NCBITaxon:72037 ! Maxillopoda [Term] id: NCBITaxon:6843 name: Chelicerata synonym: "chelicerates" EXACT [] is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:6854 name: Arachnida synonym: "arachnids" EXACT [] synonym: "arachnids" RELATED [] is_a: NCBITaxon:6843 ! Chelicerata [Term] id: NCBITaxon:6960 name: Hexapoda synonym: "Atelocerata" RELATED [] synonym: "insects" EXACT [] synonym: "insects" RELATED [] synonym: "Tracheata" RELATED [] synonym: "Uniramia" RELATED [] is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:7088 name: Lepidoptera synonym: "butterflies and moths" EXACT [] synonym: "moths" EXACT [] synonym: "moths" RELATED [] is_a: NCBITaxon:85604 ! Amphiesmenoptera [Term] id: NCBITaxon:7147 name: Diptera synonym: "flies" EXACT [] synonym: "flies" RELATED [] is_a: NCBITaxon:33392 ! Endopterygota [Term] id: NCBITaxon:7203 name: Brachycera is_a: NCBITaxon:7147 ! Diptera [Term] id: NCBITaxon:72037 name: Maxillopoda is_a: NCBITaxon:6657 ! Crustacea [Term] id: NCBITaxon:7214 name: Drosophilidae synonym: "pomace flies" EXACT [] is_a: NCBITaxon:43746 ! Ephydroidea [Term] id: NCBITaxon:7215 name: Drosophila synonym: "Drosophila" EXACT [] synonym: "fruit flies" EXACT [] synonym: "fruit fly" EXACT [] is_a: NCBITaxon:186285 ! Drosophiliti [Term] id: NCBITaxon:7227 name: Drosophila melanogaster synonym: "Drosophila melangaster" RELATED [] synonym: "fruit fly" EXACT [] is_a: NCBITaxon:32351 ! melanogaster subgroup [Term] id: NCBITaxon:7496 name: Pterygota synonym: "Pterygota" EXACT [] synonym: "winged insects" EXACT [] is_a: NCBITaxon:85512 ! Dicondylia [Term] id: NCBITaxon:7586 name: Echinodermata synonym: "echinoderms" EXACT [] synonym: "echinoderms" RELATED [] is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:76071 name: Beloniformes is_a: NCBITaxon:1489913 ! Atherinomorphae [Term] id: NCBITaxon:7624 name: Echinozoa is_a: NCBITaxon:133551 ! Eleutherozoa [Term] id: NCBITaxon:7625 name: Echinoidea synonym: "sea urchins" EXACT [] synonym: "sea urchins" RELATED [] is_a: NCBITaxon:7624 ! Echinozoa [Term] id: NCBITaxon:7711 name: Chordata synonym: "chordates" EXACT [] synonym: "chordates" RELATED [] is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:7712 name: Tunicata synonym: "tunicates" EXACT [] synonym: "tunicates" RELATED [] synonym: "Urochordata" RELATED [] is_a: NCBITaxon:7711 ! Chordata [Term] id: NCBITaxon:7713 name: Ascidiacea synonym: "sea squirts" EXACT [] is_a: NCBITaxon:7712 ! Tunicata [Term] id: NCBITaxon:7735 name: Cephalochordata synonym: "lancelets" RELATED [] is_a: NCBITaxon:7711 ! Chordata [Term] id: NCBITaxon:7736 name: Branchiostomidae synonym: "amphioxi" EXACT [] synonym: "amphioxius" EXACT [] synonym: "Branchiostomatidae" RELATED [] synonym: "lancelets" EXACT [] is_a: NCBITaxon:7735 ! Cephalochordata [Term] id: NCBITaxon:7737 name: Branchiostoma is_a: NCBITaxon:7736 ! Branchiostomidae [Term] id: NCBITaxon:7742 name: Vertebrata synonym: "Vertebrata" EXACT [] synonym: "vertebrates" EXACT [] synonym: "vertebrates" RELATED [] is_a: NCBITaxon:89593 ! Craniata [Term] id: NCBITaxon:7745 name: Petromyzontiformes synonym: "lampreys" RELATED [] synonym: "Petromyzoniformes" RELATED [] is_a: NCBITaxon:117569 ! Hyperoartia [Term] id: NCBITaxon:7746 name: Petromyzontidae synonym: "lampreys" EXACT [] synonym: "Petromyzonidae" RELATED [] is_a: NCBITaxon:7745 ! Petromyzontiformes [Term] id: NCBITaxon:7761 name: Myxiniformes synonym: "hagfishes" RELATED [] synonym: "Myxinoidea" RELATED [] is_a: NCBITaxon:117565 ! Hyperotreti [Term] id: NCBITaxon:7762 name: Myxinidae synonym: "hagfishes" EXACT [] is_a: NCBITaxon:7761 ! Myxiniformes [Term] id: NCBITaxon:7769 name: Myxine glutinosa synonym: "Atlantic hagfish" EXACT [] synonym: "common hagfish" EXACT [] synonym: "hagfish" EXACT [] is_a: NCBITaxon:110555 ! Myxine [Term] id: NCBITaxon:7776 name: Gnathostomata synonym: "Gnathostomata" EXACT [] synonym: "jawed vertebrates" EXACT [] is_a: NCBITaxon:7742 ! Vertebrata [Term] id: NCBITaxon:7777 name: Chondrichthyes synonym: "cartilaginous fishes" EXACT [] synonym: "cartilaginous fishes" RELATED [] synonym: "fish" EXACT [] synonym: "fishes" EXACT [] is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:7778 name: Elasmobranchii synonym: "elasmobranchs" EXACT [] synonym: "sharks and rays" RELATED [] is_a: NCBITaxon:7777 ! Chondrichthyes [Term] id: NCBITaxon:7863 name: Holocephali is_a: NCBITaxon:7777 ! Chondrichthyes [Term] id: NCBITaxon:7864 name: Chimaeriformes synonym: "chimaeras" EXACT [] synonym: "chimaeras" RELATED [] is_a: NCBITaxon:7863 ! Holocephali [Term] id: NCBITaxon:7878 name: Dipnoi synonym: "Choanichthyes" RELATED [] synonym: "Dipneusti" RELATED [] synonym: "dipnoans" EXACT [] synonym: "Dipnomorpha" RELATED [] synonym: "fish" EXACT [] synonym: "fishes" EXACT [] synonym: "lungfishes" EXACT [] synonym: "lungfishes" RELATED [] synonym: "Osteichthyes" RELATED [] is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] id: NCBITaxon:7898 name: Actinopterygii synonym: "Actinopterygi" RELATED [] synonym: "bony fishes" RELATED [] synonym: "fish" EXACT [] synonym: "fishes" EXACT [] synonym: "Osteichthyes" RELATED [] synonym: "ray-finned fishes" EXACT [] is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:7933 name: Anguilliformes synonym: "eels" EXACT [] is_a: NCBITaxon:32521 ! Elopomorpha [Term] id: NCBITaxon:7952 name: Cypriniformes is_a: NCBITaxon:186627 ! Cypriniphysae [Term] id: NCBITaxon:7953 name: Cyprinidae is_a: NCBITaxon:30727 ! Cyprinoidea [Term] id: NCBITaxon:7954 name: Danio synonym: "Brachydanio" RELATED [] synonym: "Celestichthys" RELATED [] is_a: NCBITaxon:7953 ! Cyprinidae [Term] id: NCBITaxon:7955 name: Danio rerio synonym: "Brachidanio rerio" RELATED [] synonym: "Brachydanio rerio" RELATED [] synonym: "Brachydanio rerio frankei" RELATED [] synonym: "Cyprinus rerio" RELATED [] synonym: "Cyprinus rerio Hamilton, 1822" RELATED [] synonym: "Danio frankei" RELATED [] synonym: "Danio rerio (Hamilton, 1822)" RELATED [] synonym: "Danio rerio frankei" RELATED [] synonym: "leopard danio" EXACT [] synonym: "zebra danio" EXACT [] synonym: "zebra fish" EXACT [] synonym: "zebrafish" EXACT [] is_a: NCBITaxon:7954 ! Danio [Term] id: NCBITaxon:8075 name: Atheriniformes is_a: NCBITaxon:1489913 ! Atherinomorphae [Term] id: NCBITaxon:8088 name: Oryziinae synonym: "medakas" EXACT [] synonym: "Oryziatinae" RELATED [] synonym: "ricefishes" EXACT [] is_a: NCBITaxon:47757 ! Adrianichthyidae [Term] id: NCBITaxon:8089 name: Oryzias synonym: "Orizias" RELATED [] synonym: "Xenopoecilus" RELATED [] is_a: NCBITaxon:8088 ! Oryziinae [Term] id: NCBITaxon:8090 name: Oryzias latipes synonym: "Japanese medaka" EXACT [] synonym: "Japanese rice fish" EXACT [] synonym: "medaka" EXACT [] synonym: "Orizias latipes" RELATED [] synonym: "Poecilia latipes" RELATED [] is_a: NCBITaxon:8089 ! Oryzias [Term] id: NCBITaxon:81957 name: Polychrotinae synonym: "Anolinae" RELATED [] synonym: "Polychrinae" RELATED [] synonym: "Polychrotidae" RELATED [] is_a: NCBITaxon:8515 ! Iguanidae [Term] id: NCBITaxon:8287 name: Sarcopterygii is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:8292 name: Amphibia synonym: "amphibians" EXACT [] synonym: "amphibians" RELATED [] is_a: NCBITaxon:32523 ! Tetrapoda [Term] id: NCBITaxon:8293 name: Caudata synonym: "salamanders" RELATED [] synonym: "Urodela" RELATED [] is_a: NCBITaxon:41666 ! Batrachia [Term] id: NCBITaxon:8342 name: Anura synonym: "anurans" EXACT [] synonym: "frogs" EXACT [] synonym: "frogs & toads" RELATED [] synonym: "frogs and toads" EXACT [] synonym: "Salientia" RELATED [] is_a: NCBITaxon:41666 ! Batrachia [Term] id: NCBITaxon:8352 name: Pipidae synonym: "pipid frogs" EXACT [] synonym: "tongueless frogs" EXACT [] is_a: NCBITaxon:30319 ! Pipoidea [Term] id: NCBITaxon:8353 name: Xenopus synonym: "Xenopus" EXACT [] is_a: NCBITaxon:8360 ! Xenopodinae [Term] id: NCBITaxon:8355 name: Xenopus laevis synonym: "African clawed frog" EXACT [] synonym: "Bufo laevis" RELATED [] synonym: "clawed frog" EXACT [] synonym: "common platanna" EXACT [] synonym: "platanna" EXACT [] synonym: "Xenopus laevis (Daudin, 1802)" RELATED [] synonym: "Xenopus leavis" RELATED [] is_a: NCBITaxon:262014 ! Xenopus [Term] id: NCBITaxon:8360 name: Xenopodinae synonym: "Siluraninae" RELATED [] is_a: NCBITaxon:8352 ! Pipidae [Term] id: NCBITaxon:8445 name: Gymnophiona synonym: "caecilians" RELATED [] is_a: NCBITaxon:8292 ! Amphibia [Term] id: NCBITaxon:8446 name: Caeciliidae synonym: "Caeciliinae" RELATED [] synonym: "true caecilians" EXACT [] is_a: NCBITaxon:8445 ! Gymnophiona [Term] id: NCBITaxon:8457 name: Sauropsida synonym: "sauropsids" EXACT [] is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:8459 name: Testudines synonym: "anapsid reptiles" EXACT [] synonym: "Anapsida" RELATED [] synonym: "reptiles" RELATED [] synonym: "Reptilia" RELATED [] synonym: "Testudinata" RELATED [] synonym: "turtles" EXACT [] synonym: "turtles" RELATED [] is_a: NCBITaxon:1329799 ! Testudines + Archosauria group [Term] id: NCBITaxon:8492 name: Archosauria is_a: NCBITaxon:1329799 ! Testudines + Archosauria group [Term] id: NCBITaxon:8493 name: Crocodylidae synonym: "crocodiles" RELATED [] synonym: "crocodilians" EXACT [] is_a: NCBITaxon:1298654 ! Longirostres [Term] id: NCBITaxon:8504 name: Lepidosauria synonym: "lepidosaurs" EXACT [] synonym: "lizards" RELATED [] synonym: "reptiles" RELATED [] synonym: "Reptilia" RELATED [] is_a: NCBITaxon:32561 ! Sauria [Term] id: NCBITaxon:8505 name: Sphenodontia synonym: "beaked reptiles" EXACT [] synonym: "Rhynchocephalia" RELATED [] synonym: "rhynchocephalians" EXACT [] synonym: "Rhynchosauria" RELATED [] is_a: NCBITaxon:8504 ! Lepidosauria [Term] id: NCBITaxon:8506 name: Sphenodontidae is_a: NCBITaxon:8505 ! Sphenodontia [Term] id: NCBITaxon:8507 name: Sphenodon is_a: NCBITaxon:8506 ! Sphenodontidae [Term] id: NCBITaxon:8508 name: Sphenodon punctatus synonym: "hatteria" EXACT [] synonym: "Hatteria punctata" RELATED [] synonym: "tuatara" EXACT [] is_a: NCBITaxon:8507 ! Sphenodon [Term] id: NCBITaxon:8509 name: Squamata synonym: "squamates" EXACT [] is_a: NCBITaxon:8504 ! Lepidosauria [Term] id: NCBITaxon:8511 name: Iguania synonym: "iguanian lizards" EXACT [] synonym: "Lacertilia" RELATED [] is_a: NCBITaxon:1329911 ! Toxicofera [Term] id: NCBITaxon:8515 name: Iguanidae synonym: "iguanid lizards" EXACT [] is_a: NCBITaxon:8511 ! Iguania [Term] id: NCBITaxon:85512 name: Dicondylia is_a: NCBITaxon:50557 ! Insecta [Term] id: NCBITaxon:85604 name: Amphiesmenoptera is_a: NCBITaxon:33392 ! Endopterygota [Term] id: NCBITaxon:8570 name: Serpentes synonym: "Ophidia" RELATED [] synonym: "snakes" EXACT [] synonym: "snakes" RELATED [] is_a: NCBITaxon:1329911 ! Toxicofera [Term] id: NCBITaxon:8578 name: Colubridae synonym: "colubrid snakes" EXACT [] is_a: NCBITaxon:34989 ! Colubroidea [Term] id: NCBITaxon:862507 name: Mus synonym: "Mus" EXACT [] is_a: NCBITaxon:10088 ! Mus [Term] id: NCBITaxon:8782 name: Aves synonym: "birds" EXACT [] synonym: "birds" RELATED [] is_a: NCBITaxon:436492 ! Coelurosauria [Term] id: NCBITaxon:8825 name: Neognathae is_a: NCBITaxon:8782 ! Aves [Term] id: NCBITaxon:8826 name: Anseriformes is_a: NCBITaxon:8825 ! Neognathae [Term] id: NCBITaxon:8827 name: Anhimidae synonym: "screamers" EXACT [] is_a: NCBITaxon:8826 ! Anseriformes [Term] id: NCBITaxon:88770 name: Panarthropoda is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:89593 name: Craniata synonym: "Craniata" EXACT [] is_a: NCBITaxon:7711 ! Chordata [Term] id: NCBITaxon:8976 name: Galliformes synonym: "fowls" EXACT [] is_a: NCBITaxon:8825 ! Neognathae [Term] id: NCBITaxon:9005 name: Phasianidae synonym: "turkeys" EXACT [] is_a: NCBITaxon:8976 ! Galliformes [Term] id: NCBITaxon:9030 name: Gallus is_a: NCBITaxon:9072 ! Phasianinae [Term] id: NCBITaxon:9031 name: Gallus gallus synonym: "bantam" EXACT [] synonym: "chicken" EXACT [] synonym: "chickens" EXACT [] synonym: "Gallus domesticus" RELATED [] synonym: "Gallus gallus domesticus" RELATED [] is_a: NCBITaxon:9030 ! Gallus [Term] id: NCBITaxon:9072 name: Phasianinae is_a: NCBITaxon:9005 ! Phasianidae [Term] id: NCBITaxon:91561 name: Cetartiodactyla synonym: "even-toed ungulates" RELATED [] synonym: "whales, hippos, ruminants, pigs, camels etc." EXACT [] is_a: NCBITaxon:314145 ! Laurasiatheria [Term] id: NCBITaxon:9254 name: Prototheria is_a: NCBITaxon:40674 ! Mammalia [Term] id: NCBITaxon:9255 name: Monotremata synonym: "egg-laying mammals" EXACT [] synonym: "monotremes" RELATED [] is_a: NCBITaxon:9254 ! Prototheria [Term] id: NCBITaxon:9256 name: Ornithorhynchidae is_a: NCBITaxon:9255 ! Monotremata [Term] id: NCBITaxon:9257 name: Ornithorhynchus synonym: "Ornythorhynchus" RELATED [] is_a: NCBITaxon:9256 ! Ornithorhynchidae [Term] id: NCBITaxon:9258 name: Ornithorhynchus anatinus synonym: "duck-billed platypus" EXACT [] synonym: "duckbill platypus" EXACT [] synonym: "Ornythorhynchus anatinus" RELATED [] synonym: "platypus" EXACT [] is_a: NCBITaxon:9257 ! Ornithorhynchus [Term] id: NCBITaxon:9259 name: Tachyglossidae synonym: "echidnas" EXACT [] is_a: NCBITaxon:9255 ! Monotremata [Term] id: NCBITaxon:9263 name: Metatheria synonym: "Marsupialia" RELATED [] synonym: "marsupials" EXACT [] synonym: "marsupials" RELATED [] is_a: NCBITaxon:32525 ! Theria [Term] id: NCBITaxon:9265 name: Didelphidae synonym: "American opossums" EXACT [] synonym: "opossums" EXACT [] is_a: NCBITaxon:38605 ! Didelphimorphia [Term] id: NCBITaxon:9307 name: Macropodidae is_a: NCBITaxon:38609 ! Diprotodontia [Term] id: NCBITaxon:9312 name: Macropus is_a: NCBITaxon:9307 ! Macropodidae [Term] id: NCBITaxon:9321 name: Macropus rufus synonym: "Megaleia rufa" RELATED [] synonym: "red kangaroo" EXACT [] is_a: NCBITaxon:9312 ! Macropus [Term] id: NCBITaxon:9347 name: Eutheria synonym: "eutherian mammals" EXACT [] synonym: "placental mammals" EXACT [] synonym: "Placentalia" RELATED [] synonym: "placentals" EXACT [] synonym: "placentals" RELATED [] is_a: NCBITaxon:32525 ! Theria [Term] id: NCBITaxon:9348 name: Xenarthra synonym: "Edentata" RELATED [] is_a: NCBITaxon:9347 ! Eutheria [Term] id: NCBITaxon:9359 name: Dasypodidae synonym: "armadillo" EXACT [] synonym: "armadillos" EXACT [] is_a: NCBITaxon:948951 ! Cingulata [Term] id: NCBITaxon:9362 name: Insectivora synonym: "hedgehogs, shrews, moles and others" EXACT [] synonym: "insectivores" RELATED [] synonym: "Soricomorpha" RELATED [] is_a: NCBITaxon:314145 ! Laurasiatheria [Term] id: NCBITaxon:9363 name: Erinaceidae synonym: "hedgehogs" EXACT [] is_a: NCBITaxon:9362 ! Insectivora [Term] id: NCBITaxon:9364 name: Erinaceus is_a: NCBITaxon:30577 ! Erinaceinae [Term] id: NCBITaxon:9365 name: Erinaceus europaeus synonym: "common hedgehog" EXACT [] synonym: "Erinaceous europaeus" RELATED [] synonym: "Erinaceus europeus" RELATED [] synonym: "European hedgehog" EXACT [] synonym: "western European hedgehog" EXACT [] is_a: NCBITaxon:9364 ! Erinaceus [Term] id: NCBITaxon:9373 name: Talpidae synonym: "moles, shrew-moles, and desmans" EXACT [] is_a: NCBITaxon:9362 ! Insectivora [Term] id: NCBITaxon:9397 name: Chiroptera synonym: "bats" EXACT [] synonym: "bats" RELATED [] is_a: NCBITaxon:314145 ! Laurasiatheria [Term] id: NCBITaxon:9443 name: Primates synonym: "Primata" RELATED [] synonym: "primate" EXACT [] synonym: "primates" RELATED [] is_a: NCBITaxon:314146 ! Euarchontoglires [Term] id: NCBITaxon:9475 name: Tarsiidae synonym: "tarsiers" EXACT [] is_a: NCBITaxon:376912 ! Tarsiiformes [Term] id: NCBITaxon:9479 name: Platyrrhini synonym: "monkey" EXACT [] synonym: "monkeys" EXACT [] synonym: "New World monkeys" EXACT [] is_a: NCBITaxon:314293 ! Simiiformes [Term] id: NCBITaxon:948951 name: Cingulata is_a: NCBITaxon:9348 ! Xenarthra [Term] id: NCBITaxon:94929 name: Ophidiiformes is_a: NCBITaxon:1489873 ! Ophidiimorpharia [Term] id: NCBITaxon:9499 name: Alouatta synonym: "howler monkeys" EXACT [] is_a: NCBITaxon:38066 ! Alouattinae [Term] id: NCBITaxon:9526 name: Catarrhini is_a: NCBITaxon:314293 ! Simiiformes [Term] id: NCBITaxon:9527 name: Cercopithecidae synonym: "monkey" EXACT [] synonym: "monkeys" EXACT [] synonym: "Old World monkeys" EXACT [] is_a: NCBITaxon:314294 ! Cercopithecoidea [Term] id: NCBITaxon:9528 name: Cercopithecinae is_a: NCBITaxon:9527 ! Cercopithecidae [Term] id: NCBITaxon:9539 name: Macaca synonym: "macaque" EXACT [] synonym: "macaques" EXACT [] is_a: NCBITaxon:9528 ! Cercopithecinae [Term] id: NCBITaxon:9544 name: Macaca mulatta synonym: "rhesus macaque" EXACT [] synonym: "rhesus macaques" EXACT [] synonym: "Rhesus monkey" EXACT [] synonym: "rhesus monkeys" EXACT [] is_a: NCBITaxon:9539 ! Macaca [Term] id: NCBITaxon:9592 name: Gorilla is_a: NCBITaxon:207598 ! Homininae [Term] id: NCBITaxon:9593 name: Gorilla gorilla synonym: "gorilla" EXACT [] synonym: "western gorilla" EXACT [] is_a: NCBITaxon:9592 ! Gorilla [Term] id: NCBITaxon:9596 name: Pan synonym: "chimpanzees" EXACT [] is_a: NCBITaxon:207598 ! Homininae [Term] id: NCBITaxon:9597 name: Pan paniscus synonym: "bonobo" EXACT [] synonym: "pygmy chimpanzee" EXACT [] is_a: NCBITaxon:9596 ! Pan [Term] id: NCBITaxon:9598 name: Pan troglodytes synonym: "Chimpansee troglodytes" RELATED [] synonym: "chimpanzee" EXACT [] is_a: NCBITaxon:9596 ! Pan [Term] id: NCBITaxon:9599 name: Pongo is_a: NCBITaxon:607660 ! Ponginae [Term] id: NCBITaxon:9600 name: Pongo pygmaeus synonym: "Bornean orangutan" EXACT [] synonym: "orang utan" EXACT [] synonym: "Orang-utan" EXACT [] synonym: "Orangutan" EXACT [] is_a: NCBITaxon:9599 ! Pongo [Term] id: NCBITaxon:9604 name: Hominidae synonym: "great apes" EXACT [] synonym: "Pongidae" RELATED [] is_a: NCBITaxon:314295 ! Hominoidea [Term] id: NCBITaxon:9605 name: Homo is_a: NCBITaxon:207598 ! Homininae [Term] id: NCBITaxon:9606 name: Homo sapiens synonym: "human" EXACT [] synonym: "man" EXACT [] is_a: NCBITaxon:9605 ! Homo [Term] id: NCBITaxon:9608 name: Canidae synonym: "dog, coyote, wolf, fox" EXACT [] is_a: NCBITaxon:379584 ! Caniformia [Term] id: NCBITaxon:9611 name: Canis is_a: NCBITaxon:9608 ! Canidae [Term] id: NCBITaxon:9681 name: Felidae synonym: "cat family" EXACT [] is_a: NCBITaxon:379583 ! Feliformia [Term] id: NCBITaxon:9709 name: Phocidae synonym: "crawling seals" EXACT [] synonym: "earless seals" EXACT [] synonym: "seal" EXACT [] synonym: "seals" EXACT [] synonym: "true seals" EXACT [] is_a: NCBITaxon:379584 ! Caniformia [Term] id: NCBITaxon:9721 name: Cetacea synonym: "whale" EXACT [] synonym: "whales" EXACT [] synonym: "whales & dolphins" RELATED [] synonym: "whales, dolphins, and porpoises" EXACT [] is_a: NCBITaxon:91561 ! Cetartiodactyla [Term] id: NCBITaxon:9722 name: Odontoceti synonym: "tooth whales" EXACT [] is_a: NCBITaxon:9721 ! Cetacea [Term] id: NCBITaxon:9747 name: Monodontidae is_a: NCBITaxon:9722 ! Odontoceti [Term] id: NCBITaxon:9750 name: Physeteridae synonym: "sperm whales" EXACT [] is_a: NCBITaxon:9722 ! Odontoceti [Term] id: NCBITaxon:9753 name: Physeter is_a: NCBITaxon:9750 ! Physeteridae [Term] id: NCBITaxon:9761 name: Mysticeti synonym: "baleen whales" EXACT [] is_a: NCBITaxon:9721 ! Cetacea [Term] id: NCBITaxon:9765 name: Balaenopteridae synonym: "finback whales" EXACT [] synonym: "rorquals" EXACT [] is_a: NCBITaxon:9761 ! Mysticeti [Term] id: NCBITaxon:9779 name: Proboscidea synonym: "elephants" EXACT [] synonym: "Proboscidea" EXACT [] is_a: NCBITaxon:311790 ! Afrotheria [Term] id: NCBITaxon:9787 name: Perissodactyla synonym: "odd-toed ungulates" EXACT [] synonym: "odd-toed ungulates" RELATED [] is_a: NCBITaxon:314145 ! Laurasiatheria [Term] id: NCBITaxon:9788 name: Equidae synonym: "horses" EXACT [] is_a: NCBITaxon:9787 ! Perissodactyla [Term] id: NCBITaxon:9815 name: Tubulidentata synonym: "aardvarks" EXACT [] synonym: "Edentata" RELATED [] is_a: NCBITaxon:311790 ! Afrotheria [Term] id: NCBITaxon:9816 name: Orycteropodidae synonym: "aardvark" EXACT [] synonym: "aardvarks" EXACT [] is_a: NCBITaxon:9815 ! Tubulidentata [Term] id: NCBITaxon:9821 name: Suidae synonym: "boars" EXACT [] synonym: "pigs" EXACT [] is_a: NCBITaxon:35497 ! Suina [Term] id: NCBITaxon:9822 name: Sus is_a: NCBITaxon:9821 ! Suidae [Term] id: NCBITaxon:9823 name: Sus scrofa synonym: "pig" EXACT [] synonym: "pigs" EXACT [] synonym: "Sus scrofus" RELATED [] synonym: "swine" EXACT [] synonym: "wild boar" EXACT [] is_a: NCBITaxon:9822 ! Sus [Term] id: NCBITaxon:9834 name: Tylopoda synonym: "Artiodactyla" RELATED [] is_a: NCBITaxon:91561 ! Cetartiodactyla [Term] id: NCBITaxon:9835 name: Camelidae is_a: NCBITaxon:9834 ! Tylopoda [Term] id: NCBITaxon:9836 name: Camelus is_a: NCBITaxon:9835 ! Camelidae [Term] id: NCBITaxon:9845 name: Ruminantia synonym: "Artiodactyla" RELATED [] is_a: NCBITaxon:91561 ! Cetartiodactyla [Term] id: NCBITaxon:9850 name: Cervidae synonym: "deer" EXACT [] is_a: NCBITaxon:35500 ! Pecora [Term] id: NCBITaxon:9892 name: Giraffidae is_a: NCBITaxon:35500 ! Pecora [Term] id: NCBITaxon:9895 name: Bovidae is_a: NCBITaxon:35500 ! Pecora [Term] id: NCBITaxon:9903 name: Bos synonym: "oxen, cattle" EXACT [] is_a: NCBITaxon:27592 ! Bovinae [Term] id: NCBITaxon:9913 name: Bos taurus synonym: "Bos bovis" RELATED [] synonym: "Bos primigenius taurus" RELATED [] synonym: "Bos Tauurus" RELATED [] synonym: "bovine" EXACT [] synonym: "cattle" EXACT [] synonym: "cow" EXACT [] synonym: "domestic cattle" EXACT [] synonym: "domestic cow" EXACT [] is_a: NCBITaxon:9903 ! Bos [Term] id: NCBITaxon:9975 name: Lagomorpha synonym: "rabbits & hares" RELATED [] is_a: NCBITaxon:314147 ! Glires [Term] id: NCBITaxon:99883 name: Tetraodon nigroviridis synonym: "spotted green pufferfish" EXACT [] synonym: "Tetraodon nigroviridis Marion de Proce, 1822" RELATED [] is_a: NCBITaxon:47144 ! Tetraodon [Term] id: NCBITaxon:9989 name: Rodentia synonym: "rodents" EXACT [] synonym: "rodents" RELATED [] is_a: NCBITaxon:314147 ! Glires [Term] id: PATO:0000001 name: quality [Term] id: PATO:0000050 name: life span is_a: PATO:0000165 ! time [Term] id: PATO:0000051 name: morphology is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape is_a: PATO:0000051 ! morphology [Term] id: PATO:0000068 name: qualitative is_a: PATO:0000001 ! quality [Term] id: PATO:0000069 name: deviation(from_normal) is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000117 name: size is_a: PATO:0000051 ! morphology [Term] id: PATO:0000165 name: time is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000261 name: maturity is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000406 name: curved is_a: PATO:0001591 ! curvature [Term] id: PATO:0000586 name: increased size is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality [Term] id: PATO:0000587 name: decreased size is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality [Term] id: PATO:0001018 name: physical quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001241 name: physical object quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001367 name: lobate is_a: PATO:0001925 ! surface feature shape [Term] id: PATO:0001374 name: ploidy is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001375 name: haploid is_a: PATO:0001393 ! euploid [Term] id: PATO:0001393 name: euploid is_a: PATO:0001374 ! ploidy [Term] id: PATO:0001394 name: diploid is_a: PATO:0001393 ! euploid [Term] id: PATO:0001396 name: cellular quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001397 name: cellular potency is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001400 name: unipotent is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001401 name: oligopotent is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001402 name: multipotent is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001404 name: nucleate quality is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001405 name: anucleate is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0001406 name: binucleate is_a: PATO:0001908 ! multinucleate [Term] id: PATO:0001407 name: mononucleate is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001410 name: striated is_a: PATO:0000052 ! shape [Term] id: PATO:0001501 name: immature is_a: PATO:0000261 ! maturity [Term] id: PATO:0001591 name: curvature is_a: PATO:0000052 ! shape [Term] id: PATO:0001604 name: decreased life span is_a: PATO:0000050 ! life span is_a: PATO:0002303 ! decreased object quality [Term] id: PATO:0001789 name: domed is_a: PATO:0000406 ! curved [Term] id: PATO:0001857 name: concave is_a: PATO:0002005 ! concavity [Term] id: PATO:0001871 name: reniform is_a: PATO:0002008 ! concave 3-D shape [Term] id: PATO:0001873 name: cylindrical is_a: PATO:0002007 ! convex 3-D shape [Term] id: PATO:0001874 name: discoid is_a: PATO:0001873 ! cylindrical [Term] id: PATO:0001908 name: multinucleate is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001925 name: surface feature shape is_a: PATO:0000052 ! shape [Term] id: PATO:0001979 name: lobed is_a: PATO:0000052 ! shape [Term] id: PATO:0001995 name: organismal quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0002005 name: concavity is_a: PATO:0000052 ! shape [Term] id: PATO:0002007 name: convex 3-D shape is_a: PATO:0002266 ! 3-D shape [Term] id: PATO:0002008 name: concave 3-D shape is_a: PATO:0002266 ! 3-D shape relationship: has_part PATO:0001857 ! concave [Term] id: PATO:0002039 name: biconcave is_a: PATO:0001857 ! concave [Term] id: PATO:0002070 name: affinity is_a: PATO:0002182 ! molecular quality [Term] id: PATO:0002094 name: basophilic is_a: PATO:0002070 ! affinity [Term] id: PATO:0002182 name: molecular quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0002266 name: 3-D shape is_a: PATO:0000052 ! shape [Term] id: PATO:0002300 name: increased quality is_a: PATO:0000069 ! deviation(from_normal) [Term] id: PATO:0002301 name: decreased quality is_a: PATO:0000069 ! deviation(from_normal) [Term] id: PATO:0002303 name: decreased object quality is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality [Term] id: PATO:0002305 name: increased object quality is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality [Term] id: PATO:0002478 name: transversely striated is_a: PATO:0001410 ! striated [Term] id: PATO:0002479 name: obliquely striated is_a: PATO:0001410 ! striated [Term] id: PATO:0002505 name: nucleated is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0002506 name: alobate is_a: PATO:0001925 ! surface feature shape [Term] id: PR:000000001 name: protein namespace: protein def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA." [] comment: Proteins descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]. is_a: PR:000018263 ! amino acid chain [Term] id: PR:000001002 name: CD19 molecule namespace: protein def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte surface antigen B4" EXACT [] synonym: "CD19" EXACT [] synonym: "differentiation antigen CD19" EXACT [] synonym: "T-cell surface antigen Leu-12" EXACT [] xref: PIRSF:PIRSF016630 is_a: PR:000000001 ! protein [Term] id: PR:000001003 name: CD34 molecule namespace: protein def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [] comment: Category=gene. Requested by=CL. synonym: "CD34" EXACT [] synonym: "hematopoietic progenitor cell antigen CD34" EXACT [] xref: PIRSF:PIRSF028749 is_a: PR:000000001 ! protein [Term] id: PR:000001004 name: CD4 molecule namespace: protein def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [] comment: Category=gene. Requested by=CL. synonym: "CD4" EXACT [] synonym: "T-cell differentiation antigen L3T4" EXACT [] synonym: "T-cell surface antigen T4/Leu-3" EXACT [] synonym: "T-cell surface glycoprotein CD4" EXACT [] xref: PIRSF:PIRSF001977 is_a: PR:000000001 ! protein [Term] id: PR:000001005 name: integrin alpha with A domain namespace: protein def: "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (PF00092) (I-domain) of approximately 200 amino acid residues at the N-terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." [] comment: Category=family. synonym: "integrin alpha with I domain" EXACT [] xref: PIRSF:PIRSF002497 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000001006 name: receptor-type tyrosine-protein phosphatase C namespace: protein def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (PF00041) followed by two copies of the Protein-tyrosine phosphatase (PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [] comment: Category=gene. Requested by=CL. synonym: "CD45" EXACT [] synonym: "L-CA" EXACT [] synonym: "leukocyte common antigen" EXACT [] synonym: "ly-5" EXACT [] synonym: "lymphocyte antigen 5" EXACT [] synonym: "PTPRC" EXACT [] synonym: "T200" BROAD [] xref: PIRSF:PIRSF002004 is_a: PR:000000001 ! protein [Term] id: PR:000001008 name: integrin alpha-2 namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGA2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD49 antigen-like family member B" EXACT [] synonym: "CD49b" EXACT [] synonym: "collagen receptor" EXACT [] synonym: "GPIa" EXACT [] synonym: "ITGA2" EXACT [] synonym: "platelet membrane glycoprotein Ia" EXACT [] synonym: "VLA-2 subunit alpha" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001010 name: integrin alpha-E namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAE gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD103" EXACT [] synonym: "HML-1 antigen" EXACT [] synonym: "integrin alpha M290" EXACT [] synonym: "integrin alpha-IEL" EXACT [] synonym: "ITGAE" EXACT [] synonym: "mucosal lymphocyte 1 antigen" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001012 name: integrin alpha-M namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member B" EXACT [] synonym: "CD11b" EXACT [] synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT [] synonym: "CR-3 alpha chain" EXACT [] synonym: "CR3A" RELATED [] synonym: "ITGAM" EXACT [] synonym: "leukocyte adhesion receptor MO1" EXACT [] synonym: "neutrophil adherence receptor" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001013 name: integrin alpha-X namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." [] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member C" EXACT [] synonym: "CD11c" EXACT [] synonym: "ITGAX" EXACT [] synonym: "Leu M5" EXACT [] synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain" EXACT [] synonym: "leukocyte adhesion receptor p150,95" EXACT [] is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001014 name: receptor-type tyrosine-protein phosphatase C isoform CD45R namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-1." [] comment: Category=sequence. Requested by=CL. synonym: "B220" RELATED [] synonym: "CD45R" EXACT [] synonym: "CD45RABC" EXACT [] synonym: "PTPRC/iso:CD45R" EXACT [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001015 name: receptor-type tyrosine-protein phosphatase C isoform CD45RA namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C)." [] comment: Category=sequence. Requested by=CL. synonym: "CD45RA" EXACT [] synonym: "PTPRC/iso:CD45RA" EXACT [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001017 name: receptor-type tyrosine-protein phosphatase C isoform CD45RO namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-2." [] comment: Category=sequence. Requested by=CL. synonym: "180 kDa form" EXACT [] synonym: "PTPRC/iso:CD45RO" EXACT [] synonym: "T200" RELATED [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001018 name: CD3 subunit with immunoglobulin domain namespace: protein def: "A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [] comment: Category=family. synonym: "CD3 subunit with Ig-like domain" EXACT [] xref: PIRSF:PIRSF001993 is_a: PR:000000001 ! protein [Term] id: PR:000001020 name: CD3 epsilon namespace: protein def: "A CD3 subunit that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD3E" EXACT [] synonym: "CD3e" EXACT [] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain" EXACT [] synonym: "T3E" RELATED [] is_a: PR:000001018 ! CD3 subunit with immunoglobulin domain [Term] id: PR:000001022 name: neural cell adhesion molecule namespace: protein def: "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." [] comment: Category=family. xref: PIRSF:PIRSF002507 is_a: PR:000000001 ! protein [Term] id: PR:000001023 name: neural cell adhesion molecule NCAM namespace: protein def: "A neural cell adhesion molecule which is involved in neuronal development, synaptic plasticity, and regeneration." [] comment: Category=family. xref: PIRSF:PIRSF501037 is_a: PR:000001022 ! neural cell adhesion molecule [Term] id: PR:000001024 name: neural cell adhesion molecule 1 namespace: protein def: "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD56" EXACT [] synonym: "N-CAM-1" EXACT [] synonym: "NCAM" RELATED [] synonym: "NCAM-1" EXACT [] synonym: "NCAM1" EXACT [] is_a: PR:000001023 ! neural cell adhesion molecule NCAM [Term] id: PR:000001025 name: C-type lectin with multiple lectin domains namespace: protein def: "A protein that is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single Fibronectin type II (FNII) domain (PF00040) and eight to ten copies of the Lectin C-type domain (PF00059) (CTLDs). The presence of multiple copies of the CTLD domain is a hallmark of this class." [] comment: Category=family. xref: PIRSF:PIRSF002427 is_a: PR:000000001 ! protein [Term] id: PR:000001026 name: lymphocyte antigen 75 namespace: protein def: "A C-type lectin with multiple lectin domains that is a translation product of the human LY75 gene or a 1:1 ortholog thereof. It consists of 12 extracellular domains (an N-terminal cysteine-rich domain, a fibronectin type II domain and 10 C-type carbohydrate recognition domains), a transmembrane region and a small cytoplasmic C terminus containing a single Tyr residue, but no obvious kinase domain. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment." [] comment: Category=gene. Requested by=CL. synonym: "C-type lectin domain family 13 member B" EXACT [] synonym: "CD205" EXACT [] synonym: "CLEC13B" RELATED [] synonym: "DEC-205" EXACT [] synonym: "gp200-MR6" EXACT [] synonym: "ly-75" EXACT [] synonym: "LY75" EXACT [] is_a: PR:000001025 ! C-type lectin with multiple lectin domains [Term] id: PR:000001083 name: CD2 molecule namespace: protein def: "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD2" EXACT [] synonym: "erythrocyte receptor" EXACT [] synonym: "LFA-2" EXACT [] synonym: "LFA-3 receptor" EXACT [] synonym: "ly-37" EXACT [] synonym: "lymphocyte antigen 37" EXACT [] synonym: "rosette receptor" EXACT [] synonym: "SRBC" RELATED [] synonym: "T-cell surface antigen CD2" EXACT [] synonym: "T-cell surface antigen T11/Leu-5" EXACT [] synonym: "T-cell surface glycoprotein CD2" EXACT [] xref: PIRSF:PIRSF001984 is_a: PR:000000001 ! protein [Term] id: PR:000001084 name: T-cell surface glycoprotein CD8 alpha chain namespace: protein def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [] comment: Category=gene. Requested by=CL. synonym: "CD8A" EXACT [] synonym: "CD8a" EXACT [] synonym: "Lyt-2" RELATED [] synonym: "Lyt2" RELATED [] synonym: "MAL" RELATED [] synonym: "T-cell surface glycoprotein Lyt-2" EXACT [] synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT [] xref: PANTHER:PTHR10441\:SF1 is_a: PR:000000001 ! protein [Term] id: PR:000001085 name: T-cell surface glycoprotein CD8 beta chain namespace: protein def: "A protein that is a translation product of the human CD8B1 gene or a 1:1 ortholog thereof. CCD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [] comment: Category=gene. synonym: "CD8b" EXACT [] synonym: "CD8B1" EXACT [] synonym: "Ly-3" RELATED [] synonym: "lymphocyte antigen 3" EXACT [] synonym: "Lyt-3" RELATED [] synonym: "Lyt3" RELATED [] synonym: "T-cell membrane glycoprotein Ly-3" EXACT [] synonym: "T-cell surface glycoprotein Lyt-3" EXACT [] xref: PIRSF:PIRSF002020 is_a: PR:000000001 ! protein [Term] id: PR:000001094 name: rhodopsin-like G-protein coupled receptor namespace: protein def: "A protein that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." [] comment: Category=family. synonym: "class 1 G-protein coupled receptor" EXACT [] xref: PIRSF:PIRSF800006 is_a: PR:000000001 ! protein [Term] id: PR:000001128 name: chemokine receptor namespace: protein def: "A rhodopsin-like G protein coupled receptor whose active form binds one or more chemokines. Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list." [] comment: Category=family. xref: PIRSF:PIRSF038545 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001197 name: chemokine receptor CCR1/3/1L namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the CCR1, CCR3, or CCR1L1 genes (the last found so far only in mouse)." [] comment: Category=family. xref: PIRSF:PIRSF501024 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001199 name: C-C chemokine receptor type 2 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-2" EXACT [] synonym: "CC-CKR-2" EXACT [] synonym: "CCR-2" EXACT [] synonym: "CCR2" EXACT [] synonym: "CD192" EXACT [] synonym: "chemokine receptor CCR2" EXACT [] synonym: "CMKBR2" RELATED [] synonym: "JE/FIC receptor" EXACT [] synonym: "MCP-1 receptor" EXACT [] synonym: "MCP-1-R" EXACT [] synonym: "monocyte chemoattractant protein 1 receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001200 name: C-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR4 gene or a 1:1 ortholog thereof. The preferred ligands include CCL17 and CCL22." [] comment: Category=gene. synonym: "C-C CKR-4" EXACT [] synonym: "CC-CKR-4" EXACT [] synonym: "CCR-4" EXACT [] synonym: "CCR4" EXACT [] synonym: "CD194" EXACT [] synonym: "chemokine receptor CCR4" EXACT [] synonym: "CMKBR4" RELATED [] synonym: "K5-5" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001201 name: C-C chemokine receptor type 5 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR5 gene or a 1:1 ortholog thereof. The preferred ligands include CCL3, CCL4, CCL5, CCL8, CCL14." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-5" EXACT [] synonym: "CC-CKR-5" EXACT [] synonym: "CCR-5" EXACT [] synonym: "CCR5" EXACT [] synonym: "CD195" EXACT [] synonym: "chemokine receptor CCR5" EXACT [] synonym: "CHEMR13" EXACT [] synonym: "CMKBR5" RELATED [] synonym: "HIV-1 fusion coreceptor" EXACT [] synonym: "MIP-1 alpha receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001202 name: C-C chemokine receptor type 6 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-6" EXACT [] synonym: "CC-CKR-6" EXACT [] synonym: "CCR-6" EXACT [] synonym: "CCR6" EXACT [] synonym: "CD196" EXACT [] synonym: "chemokine receptor CCR6" EXACT [] synonym: "chemokine receptor-like 3" EXACT [] synonym: "CKR-L3" EXACT [] synonym: "CKRL3" RELATED [] synonym: "CMKBR6" RELATED [] synonym: "DRY6" EXACT [] synonym: "G-protein coupled receptor 29" EXACT [] synonym: "GPR-CY4" EXACT [] synonym: "GPR29" RELATED [] synonym: "GPRCY4" EXACT [] synonym: "KY411" EXACT [] synonym: "LARC receptor" EXACT [] synonym: "STRL22" RELATED [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001203 name: C-C chemokine receptor type 7 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." [] comment: Category=gene. Requested by=CL. synonym: "BLR2" EXACT [] synonym: "C-C CKR-7" EXACT [] synonym: "CC-CKR-7" EXACT [] synonym: "CCR-7" EXACT [] synonym: "CCR7" EXACT [] synonym: "CD197" EXACT [] synonym: "CDw197" EXACT [] synonym: "chemokine receptor CCR7" EXACT [] synonym: "CMKBR7" RELATED [] synonym: "EBI1" EXACT [] synonym: "Ebi1h" RELATED [] synonym: "EBV-induced G-protein coupled receptor 1" EXACT [] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1" EXACT [] synonym: "EVI1" RELATED [] synonym: "MIP-3 beta receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001206 name: CX3C chemokine receptor 1 namespace: protein def: "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." [] comment: Category=gene. Requested by=CL. synonym: "beta chemokine receptor-like 1" EXACT [] synonym: "C-X3-C CKR-1" EXACT [] synonym: "chemokine receptor CX3CR1" EXACT [] synonym: "CMK-BRL-1" EXACT [] synonym: "CMK-BRL1" EXACT [] synonym: "CMKBRL1" RELATED [] synonym: "CX3CR1" EXACT [] synonym: "fractalkine receptor" EXACT [] synonym: "G-protein coupled receptor 13" EXACT [] synonym: "GPR13" RELATED [] synonym: "V28" EXACT [] xref: PIRSF:PIRSF501025 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001207 name: C-X-C chemokine receptor type 3 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR3 gene or a 1:1 ortholog thereof. The preferred ligands include CXCL9, CXCL10, CXCL11." [] comment: Category=gene. synonym: "CD183" EXACT [] synonym: "chemokine receptor CXCR3" EXACT [] synonym: "CKR-L2" EXACT [] synonym: "Cmkar3" RELATED [] synonym: "CXC-R3" EXACT [] synonym: "CXCR-3" EXACT [] synonym: "CXCR3" EXACT [] synonym: "G-protein coupled receptor 9" EXACT [] synonym: "GPR9" RELATED [] synonym: "interferon-inducible protein 10 receptor" EXACT [] synonym: "IP-10 receptor" EXACT [] xref: PIRSF:PIRSF501023 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001208 name: C-X-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12." [] comment: Category=gene. Requested by=CL. synonym: "CD184" EXACT [] synonym: "chemokine receptor CXCR4" EXACT [] synonym: "Cmkar4" RELATED [] synonym: "CXC-R4" EXACT [] synonym: "CXCR-4" EXACT [] synonym: "CXCR4" EXACT [] synonym: "FB22" EXACT [] synonym: "fusin" EXACT [] synonym: "HM89" EXACT [] synonym: "LCR1" EXACT [] synonym: "LESTR" EXACT [] synonym: "leukocyte-derived seven transmembrane domain receptor" EXACT [] synonym: "NPYRL" EXACT [] synonym: "PB-CKR" EXACT [] synonym: "pre-B-cell-derived chemokine receptor" EXACT [] synonym: "SDF-1 receptor" EXACT [] synonym: "Sdf1r" RELATED [] synonym: "stromal cell-derived factor 1 receptor" EXACT [] xref: PIRSF:PIRSF501021 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001209 name: C-X-C chemokine receptor type 5 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR5 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL13." [] comment: Category=gene. Requested by=CL. synonym: "BLR1" RELATED [] synonym: "burkitt lymphoma receptor 1" EXACT [] synonym: "burkitt lymphoma receptor 1 homolog" EXACT [] synonym: "CD185" EXACT [] synonym: "chemokine receptor CXCR5" EXACT [] synonym: "CXC-R5" EXACT [] synonym: "CXCR-5" EXACT [] synonym: "CXCR5" EXACT [] synonym: "Gpcr6" RELATED [] synonym: "MDR-15" EXACT [] synonym: "MDR15" RELATED [] synonym: "monocyte-derived receptor 15" EXACT [] xref: PANTHER:PTHR24227\:SF213 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001226 name: high affinity interleukin-8 receptor namespace: protein def: "A chemokine receptor whose active form binds interleukin-8 with high affinity." [] comment: Category=family. xref: PIRSF:PIRSF501022 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001254 name: C-C chemokine receptor type 1 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-1" EXACT [] synonym: "CC-CKR-1" EXACT [] synonym: "CCR-1" EXACT [] synonym: "CCR1" EXACT [] synonym: "CD191" EXACT [] synonym: "chemokine receptor CCR1" EXACT [] synonym: "CMKBR1" RELATED [] synonym: "CMKR1" RELATED [] synonym: "HM145" EXACT [] synonym: "LD78 receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor" EXACT [] synonym: "MIP-1alpha-R" EXACT [] synonym: "RANTES-R" EXACT [] synonym: "SCYAR1" RELATED [] is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001255 name: C-C chemokine receptor type 3 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-3" EXACT [] synonym: "CC-CKR-3" EXACT [] synonym: "CCR-3" EXACT [] synonym: "CCR3" EXACT [] synonym: "CD193" EXACT [] synonym: "chemokine receptor CCR3" EXACT [] synonym: "CKR3" EXACT [] synonym: "Cmkbr1l2" RELATED [] synonym: "CMKBR3" RELATED [] synonym: "eosinophil eotaxin receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT [] synonym: "MIP-1 alpha RL2" EXACT [] is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001256 name: C-X-C chemokine receptor type 1 namespace: protein def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD181" EXACT [] synonym: "CDw128a" EXACT [] synonym: "CMKAR1" RELATED [] synonym: "CXC-R1" EXACT [] synonym: "CXCR-1" EXACT [] synonym: "CXCR1" EXACT [] synonym: "high affinity interleukin-8 receptor A" EXACT [] synonym: "IL-8 receptor type 1" EXACT [] synonym: "IL-8R A" EXACT [] synonym: "IL8RA" RELATED [] is_a: PR:000001226 ! high affinity interleukin-8 receptor [Term] id: PR:000001257 name: C-X-C chemokine receptor type 2 namespace: protein def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD182" EXACT [] synonym: "CDw128b" EXACT [] synonym: "Cmkar2" RELATED [] synonym: "CXC-R2" EXACT [] synonym: "CXCR-2" EXACT [] synonym: "CXCR2" EXACT [] synonym: "Gpcr16" RELATED [] synonym: "GRO/MGSA receptor" EXACT [] synonym: "high affinity interleukin-8 receptor B" EXACT [] synonym: "IL-8 receptor type 2" EXACT [] synonym: "IL-8R B" EXACT [] synonym: "IL8RB" RELATED [] is_a: PR:000001226 ! high affinity interleukin-8 receptor [Term] id: PR:000001281 name: ADP-ribosyl cyclase namespace: protein def: "A protein that contains the ADP-ribosyl cyclase domain (PF02267)." [] comment: Category=family. xref: PIRSF:PIRSF005736 is_a: PR:000000001 ! protein [Term] id: PR:000001288 name: B-cell receptor CD22 namespace: protein def: "A protein that is a translation product of the human CD22 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte cell adhesion molecule" EXACT [] synonym: "BL-CAM" EXACT [] synonym: "CD22" EXACT [] synonym: "Lyb-8" RELATED [] synonym: "sialic acid-binding Ig-like lectin 2" EXACT [] synonym: "siglec-2" EXACT [] synonym: "SIGLEC2" RELATED [] synonym: "T-cell surface antigen Leu-14" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001289 name: membrane-spanning 4-domains subfamily A member 1 namespace: protein def: "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen Ly-44" EXACT [] synonym: "B-cell surface antigen CD20" EXACT [] synonym: "B-lymphocyte antigen CD20" EXACT [] synonym: "B-lymphocyte surface antigen B1" EXACT [] synonym: "Bp35" EXACT [] synonym: "CD20" EXACT [] synonym: "leukocyte surface antigen Leu-16" EXACT [] synonym: "Ly-44" RELATED [] synonym: "lymphocyte antigen 44" EXACT [] synonym: "MS4A1" EXACT [] synonym: "Ms4a2" RELATED [] xref: PIRSF:PIRSF001995 is_a: PR:000000001 ! protein [Term] id: PR:000001290 name: B7-related protein namespace: protein def: "A protein that is a member of a family that includes translation products of genes CD86, CD276, ICOSLG, and others. These are membrane-anchored proteins with a small intracellular domain and an extracellular domain with signal sequence, an Immunoglobulin V-set domain (PF07686), and a CD80-like C2-set immunoglobulin domain (PF08205)." [] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000001292 name: C-type lectin domain family 4 member C namespace: protein def: "A protein that is a translation product of the human CLEC4C gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "BDCA-2" EXACT [] synonym: "BDCA2" RELATED [] synonym: "blood dendritic cell antigen 2" EXACT [] synonym: "C-type lectin superfamily member 7" EXACT [] synonym: "CD303" EXACT [] synonym: "CLEC4C" EXACT [] synonym: "CLECSF11" RELATED [] synonym: "CLECSF7" RELATED [] synonym: "dendritic lectin" EXACT [] synonym: "DLEC" RELATED [] synonym: "HECL" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001293 name: C-type lectin domain family 4 member K namespace: protein def: "A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD207" EXACT [] synonym: "CLEC4K" RELATED [] synonym: "langerin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001300 name: CD209 molecule namespace: protein def: "A protein that is a translation product of the human CD209 gene or a 1:1 ortholog thereof." [] comment: Category=gene. This gene and CLEC4M are products of a recent gene duplication in the primate lineage. Independent duplications of an ancestral gene have given rise to several orthologs in rodents, including CD209A. Requested by=CL. synonym: "C-type lectin domain family 4 member L" EXACT [] synonym: "CD209" EXACT [] synonym: "CD209 antigen" EXACT [] synonym: "CLEC4L" RELATED [] synonym: "DC-SIGN" RELATED [] synonym: "DC-SIGN1" EXACT [] synonym: "dendritic cell-specific ICAM-3-grabbing non-integrin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001307 name: CD44 molecule namespace: protein def: "A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD44" EXACT [] synonym: "CD44 antigen" EXACT [] synonym: "CDw44" EXACT [] synonym: "ECMR-III" EXACT [] synonym: "epican" EXACT [] synonym: "extracellular matrix receptor III" EXACT [] synonym: "GP90 lymphocyte homing/adhesion receptor" EXACT [] synonym: "heparan sulfate proteoglycan" EXACT [] synonym: "hermes antigen" EXACT [] synonym: "HUTCH-I" EXACT [] synonym: "hyaluronate receptor" EXACT [] synonym: "LHR" RELATED [] synonym: "ly-24" EXACT [] synonym: "lymphocyte antigen 24" EXACT [] synonym: "MDU2" RELATED [] synonym: "MDU3" RELATED [] synonym: "MIC4" RELATED [] synonym: "PGP-1" EXACT [] synonym: "PGP-I" RELATED [] synonym: "phagocytic glycoprotein 1" EXACT [] synonym: "phagocytic glycoprotein I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001308 name: CD48 molecule namespace: protein def: "A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte activation marker BLAST-1" EXACT [] synonym: "Bcm-1" RELATED [] synonym: "BCM1" RELATED [] synonym: "BCM1 surface antigen" EXACT [] synonym: "BLAST-1" EXACT [] synonym: "BLAST1" RELATED [] synonym: "CD48" EXACT [] synonym: "CD48 antigen" EXACT [] synonym: "HM48-1" EXACT [] synonym: "leukocyte antigen MEM-102" EXACT [] synonym: "MRC OX-45 surface antigen" EXACT [] synonym: "sgp-60" EXACT [] synonym: "TCT.1" EXACT [] xref: PANTHER:PTHR12080\:SF3 xref: PIRSF:PIRSF001973 is_a: PR:000000001 ! protein [Term] id: PR:000001310 name: CD83 molecule namespace: protein def: "A protein that is a translation product of the human CD83 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell activation protein" EXACT [] synonym: "CD83" EXACT [] synonym: "CD83 antigen" EXACT [] synonym: "cell surface protein HB15" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001318 name: L-selectin namespace: protein def: "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." [] comment: Category=gene. Requested by=CL. synonym: "CD62 antigen-like family member L" EXACT [] synonym: "CD62L" EXACT [] synonym: "gp90-MEL" EXACT [] synonym: "LAM-1" EXACT [] synonym: "LECAM1" EXACT [] synonym: "leukocyte adhesion molecule 1" EXACT [] synonym: "leukocyte surface antigen Leu-8" EXACT [] synonym: "leukocyte-endothelial cell adhesion molecule 1" EXACT [] synonym: "LNHR" RELATED [] synonym: "ly-22" EXACT [] synonym: "Ly22" RELATED [] synonym: "LYAM1" RELATED [] synonym: "lymph node homing receptor" EXACT [] synonym: "lymphocyte antigen 22" EXACT [] synonym: "lymphocyte surface MEL-14 antigen" EXACT [] synonym: "SELL" EXACT [] synonym: "TQ1" EXACT [] xref: PIRSF:PIRSF002421 is_a: PR:000000001 ! protein [Term] id: PR:000001319 name: SLAM family member 5 namespace: protein def: "A protein that is a translation product of the human CD84 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD84" EXACT [] synonym: "cell surface antigen MAX.3" EXACT [] synonym: "hly9-beta" EXACT [] synonym: "leukocyte differentiation antigen CD84" EXACT [] synonym: "signaling lymphocytic activation molecule 5" EXACT [] synonym: "SLAMF5" RELATED [] xref: PANTHER:PTHR12080\:SF6 is_a: PR:000000001 ! protein [Term] id: PR:000001320 name: alpha-(1,3)-fucosyltransferase namespace: protein def: "A protein that is a stand alone version of the Glycosyltransferase family 10 (fucosyltransferase) (PF00852) domain. Proteins in this class may catalyze alpha-1,3 glycosidic linkages." [] comment: Category=family. xref: PIRSF:PIRSF005726 is_a: PR:000000001 ! protein [Term] id: PR:000001326 name: bone marrow stromal antigen 2 namespace: protein def: "A protein that is a translation product of the human BST2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "BST-2" EXACT [] synonym: "BST2" EXACT [] synonym: "CD317" EXACT [] synonym: "HM1.24 antigen" EXACT [] synonym: "tetherin" EXACT [] xref: PIRSF:PIRSF023920 is_a: PR:000000001 ! protein [Term] id: PR:000001327 name: cadherin namespace: protein def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (PF00028), a transmembrane region, and a Cadherin cytoplasmic region (PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [] comment: Category=family. xref: PIRSF:PIRSF002504 is_a: PR:000000001 ! protein [Term] id: PR:000001332 name: carcinoembryonic antigen-related cell adhesion molecule 8 namespace: protein def: "A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "carcinoembryonic antigen CGM6" EXACT [] synonym: "CD66b" EXACT [] synonym: "CD67 antigen" EXACT [] synonym: "CEACAM8" EXACT [] synonym: "CGM6" RELATED [] synonym: "non-specific cross-reacting antigen NCA-95" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001337 name: complement receptor type 1 namespace: protein def: "A protein that is a translation product of the human CR1 gene or a 1:1 ortholog thereof. There is no counterpart in mouse." [] comment: Category=gene. Requested by=CL. synonym: "C3b/C4b receptor" EXACT [] synonym: "C3BR" RELATED [] synonym: "CD35" EXACT [] synonym: "CR1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001338 name: complement receptor type 2 namespace: protein def: "A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C3DR" RELATED [] synonym: "CD21" EXACT [] synonym: "complement C3d receptor" EXACT [] synonym: "CR2" EXACT [] synonym: "Cr2" EXACT [] synonym: "EBV receptor" EXACT [] synonym: "epstein-Barr virus receptor" EXACT [] xref: PIRSF:PIRSF002484 is_a: PR:000000001 ! protein [Term] id: PR:000001343 name: CD69 molecule namespace: protein def: "A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets." [] comment: Category=gene. Requested by=CL. synonym: "activation inducer molecule" EXACT [] synonym: "AIM" EXACT [] synonym: "BL-AC/P26" EXACT [] synonym: "C-type lectin domain family 2 member C" EXACT [] synonym: "CD69" EXACT [] synonym: "CLEC2C" RELATED [] synonym: "EA1" EXACT [] synonym: "early activation antigen CD69" EXACT [] synonym: "early T-cell activation antigen p60" EXACT [] synonym: "GP32/28" EXACT [] synonym: "leukocyte surface antigen Leu-23" EXACT [] synonym: "MLR-3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001344 name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 namespace: protein def: "A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD203c" EXACT [] synonym: "E-NPP 3" EXACT [] synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 3" EXACT [] synonym: "ENPP3" EXACT [] synonym: "PD-Ibeta" EXACT [] synonym: "PDNP3" RELATED [] synonym: "phosphodiesterase I beta" EXACT [] synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001345 name: endoglin namespace: protein def: "A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD105" EXACT [] synonym: "cell surface MJ7/18 antigen" EXACT [] synonym: "Edg" RELATED [] synonym: "END" RELATED [] synonym: "ENG" EXACT [] xref: PIRSF:PIRSF038746 is_a: PR:000000001 ! protein [Term] id: PR:000001350 name: forkhead box protein P3 namespace: protein def: "A protein that is a translation product of the human FOXP3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "FOXP3" EXACT [] synonym: "IPEX" RELATED [] synonym: "scurfin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001352 name: glycophorin namespace: protein def: "A protein that contains an extracellular Glycophorin A domain (PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane." [] comment: Category=family. xref: PIRSF:PIRSF002466 is_a: PR:000000001 ! protein [Term] id: PR:000001355 name: immunoglobulin gamma Fc receptor II/III/IV namespace: protein def: "A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III." [] comment: Category=family. xref: PIRSF:PIRSF001980 is_a: PR:000000001 ! protein [Term] id: PR:000001356 name: immunoglobulin gamma Fc receptor I namespace: protein def: "A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in humans." [] comment: Category=family. synonym: "Fc-gamma receptor" RELATED [] xref: PIRSF:PIRSF001981 is_a: PR:000000001 ! protein [Term] id: PR:000001380 name: interleukin-2 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD25" EXACT [] synonym: "IL-2 receptor subunit alpha" EXACT [] synonym: "IL-2-RA" EXACT [] synonym: "IL-2R subunit alpha" EXACT [] synonym: "IL2-RA" EXACT [] synonym: "Il2r" RELATED [] synonym: "IL2RA" EXACT [] synonym: "p55" RELATED [] synonym: "TAC antigen" EXACT [] xref: PIRSF:PIRSF001954 is_a: PR:000000001 ! protein [Term] id: PR:000001381 name: interleukin-2 receptor subunit beta namespace: protein def: "A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD122" EXACT [] synonym: "high affinity IL-2 receptor subunit beta" EXACT [] synonym: "IL-2 receptor subunit beta" EXACT [] synonym: "IL-2R subunit beta" EXACT [] synonym: "IL-2RB" EXACT [] synonym: "IL2RB" EXACT [] synonym: "p70-75" EXACT [] synonym: "p75" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001398 name: leukocyte immunoglobulin-like receptor subfamily A member 4 namespace: protein def: "A protein that is a translation product of the human LILRA4 gene or a 1:1 ortholog thereof. This gene is a member of a lineage-specific gene expansion in primates." [] comment: Category=gene. Requested by=CL. synonym: "CD85 antigen-like family member G" EXACT [] synonym: "CD85g" EXACT [] synonym: "ILT-7" EXACT [] synonym: "ILT7" RELATED [] synonym: "immunoglobulin-like transcript 7" EXACT [] synonym: "LILRA4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001402 name: killer cell lectin-like receptor subfamily D member 1 namespace: protein def: "A protein that is a translation product of the human KLRD1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD94" EXACT [] synonym: "KLRD1" EXACT [] synonym: "KP43" EXACT [] synonym: "natural killer cells antigen CD94" EXACT [] synonym: "NK cell receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001403 name: tetraspanin namespace: protein def: "A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least 4 cysteine residues, including a highly conserved 'CCG' motif." [] comment: Category=family. xref: PIRSF:PIRSF002419 is_a: PR:000000001 ! protein [Term] id: PR:000001408 name: ADP-ribosyl cyclase 1 namespace: protein def: "An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cADPr hydrolase 1" EXACT [] synonym: "CD38" EXACT [] synonym: "cyclic ADP-ribose hydrolase 1" EXACT [] synonym: "I-19" EXACT [] synonym: "NIM-R5 antigen" EXACT [] synonym: "T10" EXACT [] is_a: PR:000001281 ! ADP-ribosyl cyclase [Term] id: PR:000001412 name: CD86 molecule namespace: protein def: "A B7-related protein that is a translation product of the human CD86 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activation B7-2 antigen" EXACT [] synonym: "B70" EXACT [] synonym: "BU63" EXACT [] synonym: "CD28LG2" RELATED [] synonym: "CD86" EXACT [] synonym: "CD86 antigen" EXACT [] synonym: "CTLA-4 counter-receptor B7.2" EXACT [] synonym: "early T-cell costimulatory molecule 1" EXACT [] synonym: "ETC-1" EXACT [] synonym: "FUN-1" EXACT [] synonym: "T-lymphocyte activation antigen CD86" EXACT [] xref: PANTHER:PTHR25462\:SF45 is_a: PR:000001290 ! B7-related protein [Term] id: PR:000001431 name: N-formyl peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the FPR1, FPR2, or FPR3 gene and whose active form binds N-formyl methionyl peptides." [] comment: Category=family. xref: PIRSF:PIRSF038561 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001438 name: CD80 molecule namespace: protein def: "A B7-related protein that is a translation product of the human CD80 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activation B7-1 antigen" EXACT [] synonym: "B7" EXACT [] synonym: "BB1" EXACT [] synonym: "CD28LG" RELATED [] synonym: "CD28LG1" RELATED [] synonym: "CD80" EXACT [] synonym: "CTLA-4 counter-receptor B7.1" EXACT [] synonym: "LAB7" RELATED [] synonym: "T-lymphocyte activation antigen CD80" EXACT [] is_a: PR:000001290 ! B7-related protein [Term] id: PR:000001444 name: cadherin-5 namespace: protein def: "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "7B4 antigen" EXACT [] synonym: "CD144" EXACT [] synonym: "CDH5" EXACT [] synonym: "vascular endothelial cadherin" EXACT [] synonym: "VE-cadherin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001447 name: cadherin-1 namespace: protein def: "A cadherin that is a translation product of the human CDH1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ARC-1" EXACT [] synonym: "CAM 120/80" EXACT [] synonym: "CD324" EXACT [] synonym: "CDH1" EXACT [] synonym: "CDHE" RELATED [] synonym: "E-cadherin" EXACT [] synonym: "epithelial cadherin" EXACT [] synonym: "UVO" RELATED [] synonym: "uvomorulin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001456 name: alpha-(1,3)-fucosyltransferase FUT4 namespace: protein def: "A fucosyltransferase that is a translation product of the human FUT4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD15" EXACT [] synonym: "ELAM-1 ligand fucosyltransferase" EXACT [] synonym: "ELFT" RELATED [] synonym: "FCT3A" RELATED [] synonym: "Fuc-TIV" EXACT [] synonym: "fucosyltransferase 4" EXACT [] synonym: "fucosyltransferase FUT4" EXACT [] synonym: "fucosyltransferase IV" EXACT [] synonym: "FucT-IV" EXACT [] synonym: "FUT4" EXACT [] synonym: "galactoside 3-L-fucosyltransferase" BROAD [] is_a: PR:000001320 ! alpha-(1,3)-fucosyltransferase [Term] id: PR:000001460 name: glycophorin-A namespace: protein def: "A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain." [] comment: Category=gene. Requested by=CL. synonym: "CD235a" EXACT [] synonym: "GPA" RELATED [] synonym: "GYPA" EXACT [] synonym: "MN sialoglycoprotein" EXACT [] synonym: "PAS-2" EXACT [] synonym: "sialoglycoprotein alpha" EXACT [] is_a: PR:000001352 ! glycophorin [Term] id: PR:000001465 name: high affinity immunoglobulin gamma Fc receptor I namespace: protein def: "An immunoglobulin gamma Fc receptor I that is a translation product of the human FCGR1A gene or a 1:1 ortholog thereof." [] comment: Category=gene. The Fcgr1 gene in mouse is a 1:1 ortholog of FCGR1A, not FCGR1B. Requested by=CL. synonym: "CD64" EXACT [] synonym: "Fc-gamma RI" EXACT [] synonym: "FCG1" RELATED [] synonym: "FCGR1" RELATED [] synonym: "FCGR1A" EXACT [] synonym: "FcRI" EXACT [] synonym: "IGFR1" RELATED [] synonym: "IgG Fc receptor I" EXACT [] is_a: PR:000001356 ! immunoglobulin gamma Fc receptor I [Term] id: PR:000001479 name: low affinity immunoglobulin gamma Fc region receptor II namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD32" BROAD [] synonym: "Fc gamma receptor IIB" EXACT [] synonym: "Fc-gamma RII" EXACT [] synonym: "Fc-gamma-RIIB" EXACT [] synonym: "Fcgr2" EXACT [] synonym: "Fcgr2b" RELATED [] synonym: "FcRII" EXACT [] synonym: "IgG Fc receptor II beta" EXACT [] synonym: "ly-17" EXACT [] synonym: "lymphocyte antigen 17" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001481 name: low affinity immunoglobulin gamma Fc region receptor II-b namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD32" BROAD [] synonym: "CDw32" BROAD [] synonym: "Fc-gamma RII-b" EXACT [] synonym: "Fc-gamma-RIIb" EXACT [] synonym: "FCG2" RELATED [] synonym: "FCGR2B" EXACT [] synonym: "FcRII-b" EXACT [] synonym: "IGFR2" RELATED [] synonym: "IgG Fc receptor II-b" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001483 name: low affinity immunoglobulin gamma Fc region receptor III namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD16" EXACT [] synonym: "Fc-gamma RIII" EXACT [] synonym: "Fcgr3" EXACT [] synonym: "FcRIII" EXACT [] synonym: "IgG Fc receptor III" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001580 name: fMet-Leu-Phe receptor namespace: protein def: "An N-formyl peptide receptor that is a translation product of the human FPR1 gene or a 1:1 ortholog thereof. The preferred ligand is the peptide fMet-Leu-Phe, a bacterial peptide that acts as a chemoattractant in various pathophysiological conditions." [] comment: Category=gene. Requested by=CL. synonym: "fMLP receptor" EXACT [] synonym: "FPR" EXACT [] synonym: "FPR1" EXACT [] synonym: "N-formyl peptide receptor" BROAD [] synonym: "N-formylpeptide chemoattractant receptor" EXACT [] is_a: PR:000001431 ! N-formyl peptide receptor [Term] id: PR:000001753 name: transcription factor NF-kappa-B subunit namespace: protein def: "A protein with a core domain composition consisting of a Rel homology domain (RHD) (PF00554), an IPT/TIG domain (PF01833), six copies of the Ankyrin repeat (PF00023), a Death domain (PF00531) and a C-terminal PEST region." [] comment: Category=family. synonym: "transcription factor NF-kappa-B" RELATED [] xref: PIRSF:PIRSF036310 is_a: PR:000000001 ! protein [Term] id: PR:000001785 name: prominin namespace: protein def: "A protein with core architecture consisting of one Prominin (PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and Homo sapiens prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain." [] comment: Category=family. xref: PANTHER:PTHR22730 xref: PIRSF:PIRSF017831 is_a: PR:000000001 ! protein [Term] id: PR:000001786 name: prominin-1 namespace: protein def: "A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "antigen AC133" EXACT [] synonym: "antigen AC133 homolog" EXACT [] synonym: "CD133" EXACT [] synonym: "Prom" RELATED [] synonym: "PROM1" EXACT [] synonym: "prominin-like protein 1" EXACT [] synonym: "PROML1" RELATED [] is_a: PR:000001785 ! prominin [Term] id: PR:000001800 name: 5'-nucleotidase namespace: protein def: "A protein that is a translation product of the human NT5E gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "5'-NT" EXACT [] synonym: "CD73" EXACT [] synonym: "ecto-5'-nucleotidase" EXACT [] synonym: "NT5" RELATED [] synonym: "NT5E" EXACT [] synonym: "NTE" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001806 name: C-type lectin domain family 6 member A namespace: protein def: "A protein that is a translation product of the human CLEC6A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-type lectin superfamily member 10" EXACT [] synonym: "Clec4n" RELATED [] synonym: "CLEC6A" EXACT [] synonym: "CLECSF10" RELATED [] synonym: "DC-associated C-type lectin 2" EXACT [] synonym: "dectin-2" EXACT [] synonym: "DECTIN2" RELATED [] synonym: "dendritic cell-associated C-type lectin 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001807 name: C-type lectin domain family 7 member A namespace: protein def: "A protein that is a translation product of the human CLEC7A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "beta-glucan receptor" EXACT [] synonym: "BGR" RELATED [] synonym: "C-type lectin superfamily member 12" EXACT [] synonym: "CLEC7A" EXACT [] synonym: "CLECSF12" RELATED [] synonym: "DC-associated C-type lectin 1" EXACT [] synonym: "dectin-1" EXACT [] synonym: "DECTIN1" RELATED [] synonym: "dendritic cell-associated C-type lectin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001809 name: CD59-like glycoprotein namespace: protein def: "A protein that is a translation product of the CD59 or closely related gene. This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues." [] comment: Category=family. Requested by=CL. xref: PIRSF:PIRSF038782 is_a: PR:000000001 ! protein [Term] id: PR:000001810 name: CSF-1/PDGF receptor-type tyrosine-protein kinase namespace: protein def: "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. PF00047 is most common, but other members of the Ig domain clan, PF07679 and PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." [] comment: Category=family. xref: PIRSF:PIRSF000615 is_a: PR:000000001 ! protein [Term] id: PR:000001813 name: EGF-like module-containing mucin-like hormone receptor-like 1 namespace: protein def: "A protein that is a translation product of the human EMR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cell surface glycoprotein F4/80" EXACT [] synonym: "EGF-like module receptor 1" EXACT [] synonym: "EMR1" EXACT [] synonym: "EMR1 hormone receptor" EXACT [] synonym: "Gpf480" RELATED [] synonym: "TM7LN3" RELATED [] xref: PIRSF:PIRSF038685 is_a: PR:000000001 ! protein [Term] id: PR:000001820 name: MHC class II histocompatibility antigen alpha chain namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, an alpha domain (PF00993) and an Immunoglobulin C1-set domain (PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region. There are three major and two minor class II MHC (major histocompatability complex) alpha chain genes in humans. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants. In contrast to MHC Class I alpha chain genes, orthologies can be seem between some human and mouse genes. MHC class II alpha chains form heterodimers with MHLC class II beta chains." [] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000001832 name: SIRP/SHPS-1 family protein namespace: protein def: "A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (PF07686), two Immunoglobulin C1-set domains (PF07654), a single-pass transmembrane region and a very small cytoplasmic region." [] comment: Category=family. xref: PIRSF:PIRSF038063 is_a: PR:000000001 ! protein [Term] id: PR:000001833 name: SLAM family member 1 namespace: protein def: "A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD150" EXACT [] synonym: "CDw150" EXACT [] synonym: "IPO-3" EXACT [] synonym: "SLAM" RELATED [] synonym: "SLAMF1" EXACT [] xref: PANTHER:PTHR12080\:SF1 is_a: PR:000000001 ! protein [Term] id: PR:000001835 name: T-box transcription factor TBX21 namespace: protein def: "A protein that is a translation product of the human TBX21 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "T-box protein 21" EXACT [] synonym: "T-cell-specific T-box transcription factor T-bet" EXACT [] synonym: "TBET" RELATED [] synonym: "TBLYM" RELATED [] synonym: "TBX21" EXACT [] synonym: "transcription factor TBLYM" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001836 name: CD7 molecule namespace: protein def: "A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD7" EXACT [] synonym: "GP40" EXACT [] synonym: "T-cell antigen CD7" EXACT [] synonym: "T-cell leukemia antigen" EXACT [] synonym: "T-cell surface antigen Leu-9" EXACT [] synonym: "TP41" EXACT [] xref: PIRSF:PIRSF038791 is_a: PR:000000001 ! protein [Term] id: PR:000001838 name: T-cell surface glycoprotein CD1 namespace: protein def: "A protein with core architecture consisting of a signal sequence, an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (PF00129) and an Immunoglobulin C1-set domain (PF07654), a single-pass transmembrane region, and a very short cytoplasmic region. Forms a heterodimer with beta-2 microglobulin." [] comment: Category=family. xref: PIRSF:PIRSF038798 is_a: PR:000000001 ! protein [Term] id: PR:000001839 name: T-cell surface glycoprotein CD5 namespace: protein def: "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD5" EXACT [] synonym: "LEU1" RELATED [] synonym: "ly-1" EXACT [] synonym: "lymphocyte antigen 1" EXACT [] synonym: "lymphocyte antigen T1/Leu-1" EXACT [] synonym: "Lyt-1" EXACT [] xref: PANTHER:PTHR19331\:SF6 is_a: PR:000000001 ! protein [Term] id: PR:000001841 name: T-cell-specific surface glycoprotein CD28 namespace: protein def: "A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD28" EXACT [] synonym: "TP44" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001843 name: Thy-1 membrane glycoprotein namespace: protein def: "A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD90" EXACT [] synonym: "CDw90" EXACT [] synonym: "Thy-1" RELATED [] synonym: "Thy-1 antigen" EXACT [] synonym: "THY1" EXACT [] xref: PIRSF:PIRSF038777 is_a: PR:000000001 ! protein [Term] id: PR:000001844 name: arginase-1 namespace: protein def: "A protein that is a translation product of the human ARG1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ARG1" EXACT [] synonym: "liver-type arginase" EXACT [] synonym: "type I arginase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001850 name: cathepsin K namespace: protein def: "A protein that is a translation product of the human CTSK gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cathepsin O" RELATED [] synonym: "cathepsin O2" EXACT [] synonym: "cathepsin X" RELATED [] synonym: "CTSK" EXACT [] synonym: "CTSO" RELATED [] synonym: "CTSO2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001852 name: cytotoxic T-lymphocyte protein 4 namespace: protein def: "A protein that is a translation product of the human CTLA4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD152" EXACT [] synonym: "CTLA-4" EXACT [] synonym: "CTLA4" EXACT [] synonym: "cytotoxic T-lymphocyte-associated antigen 4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001858 name: immunoglobulin iota chain namespace: protein def: "A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells." [] comment: Category=gene. Requested by=CL. synonym: "CD179 antigen-like family member A" EXACT [] synonym: "CD179a" EXACT [] synonym: "protein VPreB1" EXACT [] synonym: "V(pre)B protein" EXACT [] synonym: "VPREB" RELATED [] synonym: "VpreB protein" EXACT [] synonym: "VPREB1" EXACT [] xref: PIRSF:PIRSF038787 is_a: PR:000000001 ! protein [Term] id: PR:000001859 name: immunoglobulin lambda-like polypeptide 1 namespace: protein def: "A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD179 antigen-like family member B" EXACT [] synonym: "CD179b" EXACT [] synonym: "Ig lambda-5" EXACT [] synonym: "Igl-5" RELATED [] synonym: "IGL1" RELATED [] synonym: "IGLL1" EXACT [] synonym: "immunoglobulin omega polypeptide" EXACT [] synonym: "immunoglobulin-related protein 14.1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001860 name: inducible T-cell costimulator namespace: protein def: "A protein that is a translation product of the human ICOS gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activation-inducible lymphocyte immunomediatory molecule" EXACT [] synonym: "AILIM" RELATED [] synonym: "CCLP" EXACT [] synonym: "CD278" EXACT [] synonym: "CD28 and CTLA-4-like protein" EXACT [] synonym: "CD28-related protein 1" EXACT [] synonym: "CRP-1" RELATED [] synonym: "ICOS" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001861 name: integrin beta namespace: protein def: "A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (PF00362), up to four EGF-like domains (PF07974), and an Integrin beta tail domain (PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (PF08725)." [] comment: Category=family. xref: PIRSF:PIRSF002512 is_a: PR:000000001 ! protein [Term] id: PR:000001865 name: interleukin-3 receptor class 2 alpha chain namespace: protein def: "A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD123" EXACT [] synonym: "IL-3 receptor subunit alpha" EXACT [] synonym: "IL-3R subunit alpha" EXACT [] synonym: "IL-3R-alpha" EXACT [] synonym: "IL-3RA" EXACT [] synonym: "IL3R" RELATED [] synonym: "IL3RA" EXACT [] synonym: "interleukin-3 receptor class II alpha chain" EXACT [] synonym: "Sut-1" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001867 name: interleukin-5 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD125" EXACT [] synonym: "CDw125" EXACT [] synonym: "IL-5 receptor subunit alpha" EXACT [] synonym: "IL-5R subunit alpha" EXACT [] synonym: "IL-5R-alpha" EXACT [] synonym: "IL-5RA" EXACT [] synonym: "IL5R" RELATED [] synonym: "IL5RA" EXACT [] xref: PIRSF:PIRSF018419 is_a: PR:000000001 ! protein [Term] id: PR:000001869 name: interleukin-7 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD127" EXACT [] synonym: "CDw127" EXACT [] synonym: "IL-7 receptor subunit alpha" EXACT [] synonym: "IL-7R subunit alpha" EXACT [] synonym: "IL-7R-alpha" EXACT [] synonym: "IL-7RA" EXACT [] synonym: "IL7R" EXACT [] xref: PIRSF:PIRSF001960 is_a: PR:000000001 ! protein [Term] id: PR:000001874 name: KLRB1-like protein namespace: protein def: "A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat." [] comment: Category=family. Requested by=CL. xref: PIRSF:PIRSF038804 is_a: PR:000000001 ! protein [Term] id: PR:000001879 name: leukosialin namespace: protein def: "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen LP-3" EXACT [] synonym: "CD43" EXACT [] synonym: "galactoglycoprotein" EXACT [] synonym: "GALGP" EXACT [] synonym: "leukocyte sialoglycoprotein" EXACT [] synonym: "ly-48" EXACT [] synonym: "lymphocyte antigen 48" EXACT [] synonym: "sialophorin" EXACT [] synonym: "SPN" EXACT [] xref: PIRSF:PIRSF001994 is_a: PR:000000001 ! protein [Term] id: PR:000001880 name: low affinity immunoglobulin epsilon Fc receptor namespace: protein def: "A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "BLAST-2" EXACT [] synonym: "C-type lectin domain family 4 member J" EXACT [] synonym: "CD23" EXACT [] synonym: "CD23A" RELATED [] synonym: "CLEC4J" RELATED [] synonym: "Fc-epsilon-RII" EXACT [] synonym: "FCE2" RELATED [] synonym: "FCER2" EXACT [] synonym: "Fcer2a" RELATED [] synonym: "IGEBF" RELATED [] synonym: "immunoglobulin E-binding factor" EXACT [] synonym: "lymphocyte IgE receptor" EXACT [] xref: PIRSF:PIRSF002426 is_a: PR:000000001 ! protein [Term] id: PR:000001883 name: lysosome-associated membrane protein namespace: protein def: "A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane." [] comment: Category=family. xref: PIRSF:PIRSF002462 is_a: PR:000000001 ! protein [Term] id: PR:000001884 name: macrophage receptor MARCO namespace: protein def: "A protein that is a translation product of the human MARCO gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "macrophage receptor with collagenous structure" EXACT [] synonym: "MARCO" EXACT [] synonym: "SCARA2" RELATED [] synonym: "scavenger receptor class A member 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001885 name: macrophage scavenger receptor types I and II namespace: protein def: "A protein that is a translation product of the human MSR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD204" EXACT [] synonym: "macrophage acetylated LDL receptor I and II" EXACT [] synonym: "MSR1" EXACT [] synonym: "SCARA1" RELATED [] synonym: "scavenger receptor class A member 1" EXACT [] synonym: "scavenger receptor type A" EXACT [] synonym: "Scvr" RELATED [] synonym: "SR-A" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001888 name: membrane alanyl aminopeptidase-like metallopeptidase namespace: protein def: "A protein with core architecture consisting of a Peptidase family M1 domain (PF01433)." [] comment: Category=family. xref: PIRSF:PIRSF005502 is_a: PR:000000001 ! protein [Term] id: PR:000001889 name: CD14 molecule namespace: protein def: "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD14" EXACT [] synonym: "monocyte differentiation antigen CD14" EXACT [] synonym: "myeloid cell-specific leucine-rich glycoprotein" EXACT [] xref: PIRSF:PIRSF002017 is_a: PR:000000001 ! protein [Term] id: PR:000001892 name: CD33 molecule namespace: protein def: "A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD33" EXACT [] synonym: "gp67" EXACT [] synonym: "myeloid cell surface antigen CD33" EXACT [] synonym: "sialic acid-binding Ig-like lectin 3" EXACT [] synonym: "siglec-3" EXACT [] synonym: "SIGLEC3" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001893 name: natural cytotoxicity triggering receptor 1 namespace: protein def: "A protein that is a translation product of the human NCR1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "activating receptor 1" EXACT [] synonym: "CD335" EXACT [] synonym: "LY94" RELATED [] synonym: "lymphocyte antigen 94" EXACT [] synonym: "lymphocyte antigen 94 homolog" EXACT [] synonym: "mAR-1" EXACT [] synonym: "natural killer cell p46-related protein" EXACT [] synonym: "NCR1" EXACT [] synonym: "NK cell-activating receptor" BROAD [] synonym: "NK-p46" EXACT [] synonym: "NKp46" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001896 name: natural killer cell receptor 2B4 namespace: protein def: "A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "2B4" RELATED [] synonym: "CD244" EXACT [] synonym: "NAIL" EXACT [] synonym: "NK cell activation-inducing ligand" EXACT [] synonym: "NK cell type I receptor protein 2B4" EXACT [] synonym: "NKR2B4" EXACT [] synonym: "Nmrk" RELATED [] synonym: "non-MHC restricted killing associated" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001897 name: natural killer cell receptor NKG2 namespace: protein def: "A protein with core architecture consisting of an as yet unnamed domain in the amino-terminal half and a carboxyl-terminal Lectin C-type domain (PF00059)." [] comment: Category=family. xref: PIRSF:PIRSF005558 is_a: PR:000000001 ! protein [Term] id: PR:000001898 name: neprilysin namespace: protein def: "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "atriopeptidase" EXACT [] synonym: "CALLA" EXACT [] synonym: "CD10" EXACT [] synonym: "common acute lymphocytic leukemia antigen" EXACT [] synonym: "enkephalinase" EXACT [] synonym: "EPN" RELATED [] synonym: "MME" EXACT [] synonym: "NEP" EXACT [] synonym: "neutral endopeptidase" EXACT [] synonym: "neutral endopeptidase 24.11" EXACT [] xref: PIRSF:PIRSF501074 is_a: PR:000000001 ! protein [Term] id: PR:000001902 name: nuclear receptor ROR-gamma namespace: protein def: "A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof." [] comment: Category=gene. synonym: "NR1F3" RELATED [] synonym: "nuclear receptor RZR-gamma" EXACT [] synonym: "nuclear receptor subfamily 1 group F member 3" EXACT [] synonym: "retinoid-related orphan receptor-gamma" EXACT [] synonym: "RORC" EXACT [] synonym: "RORG" RELATED [] synonym: "RZRG" RELATED [] synonym: "Thor" RELATED [] synonym: "thymus orphan receptor" EXACT [] synonym: "TOR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001903 name: paired box protein PAX-5 namespace: protein def: "A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell-specific transcription factor" EXACT [] synonym: "BSAP" EXACT [] synonym: "Pax-5" RELATED [] synonym: "PAX5" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001905 name: platelet glycoprotein 4 namespace: protein def: "A protein that is a translation product of the human CD36 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD36" EXACT [] synonym: "FAT" EXACT [] synonym: "fatty acid translocase" EXACT [] synonym: "glycoprotein IIIb" EXACT [] synonym: "GP3B" RELATED [] synonym: "GP4" RELATED [] synonym: "GPIIIB" EXACT [] synonym: "GPIV" EXACT [] synonym: "leukocyte differentiation antigen CD36" EXACT [] synonym: "PAS IV" EXACT [] synonym: "PAS-4" EXACT [] synonym: "platelet collagen receptor" EXACT [] synonym: "platelet glycoprotein IV" EXACT [] synonym: "thrombospondin receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001907 name: platelet glycoprotein Ib alpha chain namespace: protein def: "A protein that is a translation product of the human GP1BA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "antigen CD42b-alpha" EXACT [] synonym: "CD42b" EXACT [] synonym: "glycoprotein Ibalpha" EXACT [] synonym: "GP-Ib alpha" EXACT [] synonym: "GP1BA" EXACT [] synonym: "GPIb-alpha" EXACT [] synonym: "GPIbA" EXACT [] xref: PIRSF:PIRSF002493 is_a: PR:000000001 ! protein [Term] id: PR:000001919 name: programmed cell death protein 1 namespace: protein def: "A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD279" EXACT [] synonym: "PD-1" EXACT [] synonym: "PD1" RELATED [] synonym: "PDCD1" EXACT [] synonym: "protein PD-1" EXACT [] xref: PIRSF:PIRSF018380 is_a: PR:000000001 ! protein [Term] id: PR:000001925 name: scavenger receptor cysteine-rich type 1 protein M130 namespace: protein def: "A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD163" EXACT [] synonym: "hemoglobin scavenger receptor" EXACT [] synonym: "M130" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001927 name: sialic acid-binding Ig-like lectin 5 namespace: protein def: "A protein that is a translation product of the human SIGLEC5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD170" EXACT [] synonym: "CD33 antigen-like 2" EXACT [] synonym: "CD33L2" RELATED [] synonym: "mSiglec-F" EXACT [] synonym: "OB-binding protein 2" EXACT [] synonym: "OB-BP2" EXACT [] synonym: "OBBP2" RELATED [] synonym: "obesity-binding protein 2" EXACT [] synonym: "sialic acid-binding Ig-like lectin F" EXACT [] synonym: "siglec-5" EXACT [] synonym: "siglec-F" EXACT [] synonym: "SIGLEC5" EXACT [] synonym: "Siglecf" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001931 name: sialoadhesin namespace: protein def: "A protein that is a translation product of the human SIGLEC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD169" EXACT [] synonym: "Sa" RELATED [] synonym: "SER" EXACT [] synonym: "sheep erythrocyte receptor" EXACT [] synonym: "sialic acid-binding Ig-like lectin 1" EXACT [] synonym: "siglec-1" EXACT [] synonym: "SIGLEC1" EXACT [] synonym: "SN" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001932 name: signal transducer CD24 namespace: protein def: "A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof." [] comment: Category=gene. The mouse ortholog is Cd24a. Mouse protein Cd24b likely also orthologous. Currently it is not in UniProt. Requested by=CL. synonym: "CD24" EXACT [] synonym: "CD24A" RELATED [] synonym: "HSA" EXACT [] synonym: "ly-52" EXACT [] synonym: "lymphocyte antigen 52" EXACT [] synonym: "M1/69-J11D heat stable antigen" EXACT [] synonym: "nectadrin" EXACT [] synonym: "R13-Ag" EXACT [] synonym: "small cell lung carcinoma cluster 4 antigen" EXACT [] synonym: "X62 heat stable antigen" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001935 name: syndecan-1 namespace: protein def: "A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD138" EXACT [] synonym: "SDC" RELATED [] synonym: "SDC1" EXACT [] synonym: "Synd-1" RELATED [] synonym: "SYND1" EXACT [] xref: PIRSF:PIRSF015854 is_a: PR:000000001 ! protein [Term] id: PR:000001937 name: tartrate-resistant acid phosphatase type 5 namespace: protein def: "A protein that is a translation product of the human ACP5 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ACP5" EXACT [] synonym: "T5ap" RELATED [] synonym: "tartrate-resistant acid ATPase" EXACT [] synonym: "TR-AP" EXACT [] synonym: "Trap" RELATED [] synonym: "TrATPase" EXACT [] synonym: "type 5 acid phosphatase" EXACT [] xref: PIRSF:PIRSF000898 is_a: PR:000000001 ! protein [Term] id: PR:000001938 name: thrombomodulin-like receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (PF00059), 5 or 6 EGF-like domains (PF00008, PF09064, or PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids)." [] comment: Category=family. xref: PIRSF:PIRSF001775 is_a: PR:000000001 ! protein [Term] id: PR:000001941 name: trans-acting T-cell-specific transcription factor GATA-3 namespace: protein def: "A protein that is a translation product of the human GATA3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Gata-3" RELATED [] synonym: "GATA-binding factor 3" EXACT [] synonym: "GATA3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001944 name: transcription factor PU.1 namespace: protein def: "A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "31 kDa-transforming protein" EXACT [] synonym: "SFFV proviral integration 1 protein" EXACT [] synonym: "Sfpi-1" RELATED [] synonym: "Sfpi1" RELATED [] synonym: "SPI1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001945 name: transferrin receptor protein 1 namespace: protein def: "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD71" EXACT [] synonym: "p90" RELATED [] synonym: "T9" EXACT [] synonym: "TfR" EXACT [] synonym: "TfR1" EXACT [] synonym: "TFRC" EXACT [] synonym: "TR" RELATED [] synonym: "Trfr" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001950 name: tumor necrosis factor ligand superfamily member 5 namespace: protein def: "A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD154" EXACT [] synonym: "CD40-L" EXACT [] synonym: "CD40L" RELATED [] synonym: "CD40LG" EXACT [] synonym: "T-cell antigen Gp39" EXACT [] synonym: "TNF-related activation protein" EXACT [] synonym: "TNFSF5" RELATED [] synonym: "TRAP" BROAD [] xref: PIRSF:PIRSF016527 is_a: PR:000000001 ! protein [Term] id: PR:000001954 name: tumor necrosis factor receptor superfamily member 11A namespace: protein def: "A protein that is a translation product of the human TNFRSF11A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD265" EXACT [] synonym: "ODFR" EXACT [] synonym: "osteoclast differentiation factor receptor" EXACT [] synonym: "RANK" RELATED [] synonym: "receptor activator of NF-KB" EXACT [] synonym: "TNFRSF11A" EXACT [] xref: PIRSF:PIRSF038806 is_a: PR:000000001 ! protein [Term] id: PR:000001963 name: CD27 molecule namespace: protein def: "A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD27" EXACT [] synonym: "CD27L receptor" EXACT [] synonym: "T-cell activation antigen CD27" EXACT [] synonym: "T14" EXACT [] synonym: "TNFRSF7" RELATED [] xref: PIRSF:PIRSF001966 is_a: PR:000000001 ! protein [Term] id: PR:000001968 name: tyrosine-protein phosphatase non-receptor type substrate 1 namespace: protein def: "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Bit" EXACT [] synonym: "brain Ig-like molecule with tyrosine-based activation motifs" EXACT [] synonym: "CD172 antigen-like family member A" EXACT [] synonym: "CD172a" EXACT [] synonym: "inhibitory receptor SHPS-1" EXACT [] synonym: "macrophage fusion receptor" EXACT [] synonym: "MFR" RELATED [] synonym: "mSIRP-alpha1" EXACT [] synonym: "MyD-1 antigen" EXACT [] synonym: "MYD1" RELATED [] synonym: "p84" EXACT [] synonym: "PTPNS1" RELATED [] synonym: "SHP substrate 1" EXACT [] synonym: "SHPS-1" EXACT [] synonym: "SHPS1" RELATED [] synonym: "signal-regulatory protein alpha-1" EXACT [] synonym: "signal-regulatory protein alpha-2" EXACT [] synonym: "signal-regulatory protein alpha-3" EXACT [] synonym: "SIRP" RELATED [] synonym: "Sirp-alpha-1" EXACT [] synonym: "Sirp-alpha-2" EXACT [] synonym: "Sirp-alpha-3" EXACT [] synonym: "SIRPA" EXACT [] is_a: PR:000001832 ! SIRP/SHPS-1 family protein [Term] id: PR:000001969 name: urokinase plasminogen activator surface receptor namespace: protein def: "A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD87" EXACT [] synonym: "MO3" RELATED [] synonym: "monocyte activation antigen Mo3" EXACT [] synonym: "PLAUR" EXACT [] synonym: "U-PAR" EXACT [] synonym: "uPAR" EXACT [] xref: PIRSF:PIRSF002022 is_a: PR:000000001 ! protein [Term] id: PR:000001971 name: vascular endothelial growth factor receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (PF00047, PF07679, or PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [] comment: Category=family. xref: PIRSF:PIRSF038502 is_a: PR:000000001 ! protein [Term] id: PR:000002001 name: receptor-type tyrosine-protein kinase FLT3 namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD135" EXACT [] synonym: "fetal liver kinase 2" EXACT [] synonym: "FLK-2" EXACT [] synonym: "FLT-3" EXACT [] synonym: "FLT3" EXACT [] synonym: "Fms-like tyrosine kinase 3" EXACT [] synonym: "stem cell tyrosine kinase 1" EXACT [] synonym: "STK-1" RELATED [] synonym: "STK1" RELATED [] synonym: "tyrosine-protein kinase FLT3" EXACT [] synonym: "tyrosine-protein kinase receptor flk-2" EXACT [] synonym: "tyrosine-protein kinase receptor FLT3" EXACT [] xref: PIRSF:PIRSF500949 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002015 name: MHC class II histocompatibility antigen alpha chain HLA-DRA namespace: protein def: "An MHC class II histocompatibility antigen alpha chain that is a translation product of the human HLA-DRA gene or a 1:1 ortholog thereof." [] comment: Category=gene. The mouse ortholog is called H2-EA. synonym: "H2-Ea" RELATED [] synonym: "H2-IE-alpha" EXACT [] synonym: "HLA-DRA" EXACT [] synonym: "HLA-DRA1" RELATED [] synonym: "MHC class II antigen DRA" EXACT [] is_a: PR:000001820 ! MHC class II histocompatibility antigen alpha chain [Term] id: PR:000002023 name: NKG2-A/NKG2-B type II integral membrane protein namespace: protein def: "A natural killer cell receptor NKG2 that is a translation product of the human KLRC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD159 antigen-like family member A" EXACT [] synonym: "CD159a" EXACT [] synonym: "KLRC1" EXACT [] synonym: "NK cell receptor A" EXACT [] synonym: "NKG2-A/B-activating NK receptor" EXACT [] synonym: "NKG2A" RELATED [] is_a: PR:000001897 ! natural killer cell receptor NKG2 [Term] id: PR:000002025 name: T-cell surface glycoprotein CD1a namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD1A" EXACT [] synonym: "CD1a" EXACT [] synonym: "hTa1 thymocyte antigen" EXACT [] synonym: "T-cell surface antigen T6/Leu-6" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002027 name: T-cell surface glycoprotein CD1c namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1C gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD1C" EXACT [] synonym: "CD1c" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002028 name: antigen-presenting glycoprotein CD1d namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1D gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Cd1.1" RELATED [] synonym: "CD1D" EXACT [] synonym: "CD1d" EXACT [] synonym: "CD1d.1" EXACT [] synonym: "Cd1d1" RELATED [] synonym: "R3G1" EXACT [] synonym: "T-cell surface glycoprotein CD1d" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002031 name: aminopeptidase N namespace: protein def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ANPEP gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "alanyl aminopeptidase" EXACT [] synonym: "aminopeptidase M" EXACT [] synonym: "ANPEP" EXACT [] synonym: "AP-M" EXACT [] synonym: "AP-N" EXACT [] synonym: "APN" RELATED [] synonym: "CD13" EXACT [] synonym: "gp150" EXACT [] synonym: "Lap-1" RELATED [] synonym: "Lap1" RELATED [] synonym: "membrane protein p161" EXACT [] synonym: "microsomal aminopeptidase" EXACT [] synonym: "myeloid plasma membrane glycoprotein CD13" EXACT [] synonym: "PEPN" RELATED [] is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase [Term] id: PR:000002037 name: complement component C1q receptor namespace: protein def: "A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Aa4" RELATED [] synonym: "C1q/MBL/SPA receptor" EXACT [] synonym: "C1qR" EXACT [] synonym: "C1qR(p)" EXACT [] synonym: "C1QR1" RELATED [] synonym: "C1qRp" EXACT [] synonym: "CD93" EXACT [] synonym: "CDw93" EXACT [] synonym: "cell surface antigen AA4" EXACT [] synonym: "complement component 1 q subcomponent receptor 1" EXACT [] synonym: "ly-68" EXACT [] synonym: "Ly68" RELATED [] synonym: "lymphocyte antigen 68" EXACT [] synonym: "matrix-remodeling-associated protein 4" EXACT [] synonym: "MXRA4" RELATED [] is_a: PR:000001938 ! thrombomodulin-like receptor [Term] id: PR:000002039 name: glutamyl aminopeptidase namespace: protein def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "aminopeptidase A" EXACT [] synonym: "AP-A" EXACT [] synonym: "BP-1/6C3 antigen" EXACT [] synonym: "CD249" EXACT [] synonym: "differentiation antigen gp160" EXACT [] synonym: "EAP" RELATED [] synonym: "ENPEP" EXACT [] is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase [Term] id: PR:000002062 name: macrophage colony-stimulating factor 1 receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD115" EXACT [] synonym: "CSF-1-R" EXACT [] synonym: "CSF1R" EXACT [] synonym: "Csfmr" RELATED [] synonym: "FMS" RELATED [] synonym: "proto-oncogene c-Fms" EXACT [] xref: PIRSF:PIRSF500947 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002064 name: macrosialin namespace: protein def: "A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD68" EXACT [] synonym: "gp110" RELATED [] is_a: PR:000001883 ! lysosome-associated membrane protein [Term] id: PR:000002065 name: mast/stem cell growth factor receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD117" EXACT [] synonym: "KIT" EXACT [] synonym: "proto-oncogene c-Kit" EXACT [] synonym: "SCFR" EXACT [] synonym: "Sl" RELATED [] synonym: "tyrosine-protein kinase Kit" EXACT [] xref: PIRSF:PIRSF500951 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002105 name: thrombomodulin namespace: protein def: "A thrombomodulin-like receptor that is a translation product of the human THBD gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD141" EXACT [] synonym: "fetomodulin" EXACT [] synonym: "THBD" EXACT [] synonym: "THRM" RELATED [] synonym: "TM" EXACT [] is_a: PR:000001938 ! thrombomodulin-like receptor [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD309" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "FLK-1" EXACT [] synonym: "FLK1" RELATED [] synonym: "KDR" EXACT [] synonym: "kinase insert domain receptor" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] synonym: "VEGFR-2" EXACT [] is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000002972 name: macrophage mannose receptor 1 namespace: protein def: "A C-type lectin with multiple lectin domains that is a translation product of the human MRC1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C-type lectin domain family 13 member D" EXACT [] synonym: "C-type lectin domain family 13 member D-like" RELATED [] synonym: "CD206" EXACT [] synonym: "CLEC13D" RELATED [] synonym: "CLEC13DL" RELATED [] synonym: "macrophage mannose receptor 1-like protein 1" RELATED [] synonym: "MMR" EXACT [] synonym: "MRC1" EXACT [] synonym: "MRC1L1" RELATED [] is_a: PR:000001025 ! C-type lectin with multiple lectin domains [Term] id: PR:000002976 name: ly-6-like protein namespace: protein def: "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." [] comment: Category=family. xref: PIRSF:PIRSF002021 is_a: PR:000000001 ! protein [Term] id: PR:000002977 name: killer cell lectin-like receptor subfamily B member 1C namespace: protein alt_id: PR:000009625 def: "A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD161 antigen-like family member C" EXACT [] synonym: "CD161c" EXACT [] synonym: "Klrb1c" EXACT [] synonym: "ly-55c" EXACT [] synonym: "Ly55c" RELATED [] synonym: "lymphocyte antigen 55c" EXACT [] synonym: "natural killer cell surface protein P1-40" EXACT [] synonym: "NK1.1" EXACT [] synonym: "NKR-P1 40" EXACT [] synonym: "NKR-P1.9" EXACT [] synonym: "NKR-P1C" EXACT [] synonym: "Nkrp1c" RELATED [] is_a: PR:000001874 ! KLRB1-like protein [Term] id: PR:000002978 name: lymphocyte antigen 6G namespace: protein def: "A ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ly-6G" EXACT [] synonym: "ly-6G.1" EXACT [] synonym: "Ly6g" EXACT [] is_a: PR:000002976 ! ly-6-like protein [Term] id: PR:000002979 name: lymphocyte antigen 6A-2/6E-1 namespace: protein def: "A ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ly-6A.2/Ly-6E.1" EXACT [] synonym: "Ly6" RELATED [] synonym: "Ly6a" EXACT [] synonym: "SCA-1" RELATED [] synonym: "stem cell antigen 1" EXACT [] synonym: "T-cell-activating protein" EXACT [] synonym: "TAP" RELATED [] is_a: PR:000002976 ! ly-6-like protein [Term] id: PR:000002980 name: lymphocyte antigen 6C2 namespace: protein def: "An ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ly-6C2" EXACT [] synonym: "Ly6c" RELATED [] synonym: "Ly6c2" EXACT [] is_a: PR:000002976 ! ly-6-like protein [Term] id: PR:000002981 name: lymphocyte antigen 76 namespace: protein def: "A protein that is a translation product of the mouse Ly76 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Ly76" EXACT [] synonym: "ter-119" EXACT [] synonym: "ter119" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003450 name: B-cell lymphoma 6 protein namespace: protein alt_id: PR:000004700 def: "A protein that is a translation product of the human BCL6 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "B-cell lymphoma 5 protein" EXACT [] synonym: "BCL-5" EXACT [] synonym: "BCL-6" EXACT [] synonym: "BCL5" RELATED [] synonym: "BCL6" EXACT [] synonym: "LAZ3" RELATED [] synonym: "protein LAZ-3" EXACT [] synonym: "ZBTB27" RELATED [] synonym: "zinc finger and BTB domain-containing protein 27" EXACT [] synonym: "zinc finger protein 51" EXACT [] synonym: "ZNF51" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003455 name: nuclear receptor ROR-gamma isoform 2 namespace: protein def: "A nuclear receptor ROR-gamma that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P51450-2 or a 1:1 ortholog thereof." [] comment: Category=sequence. Requested by=CL. synonym: "RORC/iso:2" EXACT [] is_a: PR:000001902 ! nuclear receptor ROR-gamma [Term] id: PR:000003457 name: V(D)J recombination-activating protein 1 namespace: protein alt_id: PR:000013688 def: "A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "RAG-1" EXACT [] synonym: "RAG1" EXACT [] synonym: "RING finger protein 74" EXACT [] synonym: "RNF74" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003460 name: V(D)J recombination-activating protein 2 namespace: protein alt_id: PR:000013690 def: "A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "RAG-2" EXACT [] synonym: "RAG2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003463 name: eomesodermin namespace: protein alt_id: PR:000007101 def: "A T-brain transcription factor that is a translation product of the human EOMES gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "EOMES" EXACT [] synonym: "T-box brain protein 2" EXACT [] synonym: "T-brain-2" EXACT [] synonym: "TBR-2" EXACT [] synonym: "TBR2" RELATED [] is_a: PR:000003506 ! T-brain transcription factor [Term] id: PR:000003466 name: perforin-1 namespace: protein alt_id: PR:000013205 def: "A protein that is a translation product of the human PRF1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cytolysin" EXACT [] synonym: "lymphocyte pore-forming protein" EXACT [] synonym: "P1" RELATED [] synonym: "PFP" EXACT [] synonym: "PRF1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003469 name: early growth response protein 2 namespace: protein alt_id: PR:000006938 def: "A protein that is a translation product of the human EGR2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "AT591" EXACT [] synonym: "EGR-2" EXACT [] synonym: "EGR2" EXACT [] synonym: "Krox-20" RELATED [] synonym: "KROX20" RELATED [] synonym: "Zfp-25" RELATED [] synonym: "zinc finger protein Krox-20" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003499 name: granzyme B namespace: protein alt_id: PR:000003496 def: "A leukocyte granule-associated proteinase that is a translation product of the human GZMB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C11" EXACT [] synonym: "cathepsin G-like 1" EXACT [] synonym: "CGL1" RELATED [] synonym: "CSPB" RELATED [] synonym: "CTLA-1" BROAD [] synonym: "CTLA1" RELATED [] synonym: "CTSGL1" EXACT [] synonym: "cytotoxic T-lymphocyte proteinase 2" EXACT [] synonym: "fragmentin-2" BROAD [] synonym: "granzyme-2" EXACT [] synonym: "GRB" RELATED [] synonym: "GZMB" EXACT [] synonym: "HLP" RELATED [] synonym: "human lymphocyte protein" EXACT [] synonym: "lymphocyte protease" EXACT [] synonym: "SECT" EXACT [] synonym: "T-cell serine protease 1-3E" EXACT [] is_a: PR:000003505 ! leukocyte granule-associated proteinase [Term] id: PR:000003505 name: leukocyte granule-associated proteinase namespace: protein def: "A protein that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." [] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000003506 name: T-brain transcription factor namespace: protein def: "A protein that contains one copy of the T-box domain (PF00907) and it is involved in the anterior neural specification." [] comment: Category=family. synonym: "Eomes/Tbr1/Tbx21 family protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003516 name: lactosylceramide 4-alpha-galactosyltransferase namespace: protein def: "A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "A14GALT" RELATED [] synonym: "A4GALT" EXACT [] synonym: "A4GALT1" RELATED [] synonym: "alpha-1,4-galactosyltransferase" EXACT [] synonym: "alpha-1,4-N-acetylglucosaminyltransferase" BROAD [] synonym: "alpha4Gal-T1" EXACT [] synonym: "CD77 synthase" EXACT [] synonym: "Gb3 synthase" EXACT [] synonym: "globotriaosylceramide synthase" EXACT [] synonym: "P1/Pk synthase" EXACT [] synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005178 name: CD9 molecule namespace: protein def: "A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "5H9 antigen" EXACT [] synonym: "CD9" EXACT [] synonym: "CD9 antigen" EXACT [] synonym: "cell growth-inhibiting gene 2 protein" EXACT [] synonym: "leukocyte antigen MIC3" EXACT [] synonym: "MIC3" RELATED [] synonym: "motility-related protein" EXACT [] synonym: "MRP-1" EXACT [] synonym: "p24" RELATED [] synonym: "tetraspanin-29" EXACT [] synonym: "tspan-29" EXACT [] synonym: "TSPAN29" RELATED [] is_a: PR:000001403 ! tetraspanin [Term] id: PR:000005307 name: CCAAT/enhancer-binding protein alpha namespace: protein def: "A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C/EBP alpha" EXACT [] synonym: "CEBPA" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005310 name: CCAAT/enhancer-binding protein epsilon namespace: protein def: "A protein that is a translation product of the human CEBPE gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "C/EBP epsilon" EXACT [] synonym: "CEBPE" EXACT [] synonym: "Gm294" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000006169 name: cell surface glycoprotein CD200 receptor 3 namespace: protein def: "A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD200 cell surface glycoprotein receptor-like 3" EXACT [] synonym: "CD200 cell surface glycoprotein receptor-like b" EXACT [] synonym: "CD200 receptor-like 3" EXACT [] synonym: "Cd200r3" EXACT [] synonym: "CD200RLb" EXACT [] synonym: "cell surface glycoprotein OX2 receptor 3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006172 name: CD209 molecule-like protein B namespace: protein def: "A protein that is a translation product of the mouse Cd209b gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Cd209b" EXACT [] synonym: "DC-SIGN-related protein 1" EXACT [] synonym: "DC-SIGNR1" EXACT [] synonym: "OtB7" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006611 name: DNA nucleotidylexotransferase namespace: protein def: "A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "DNTT" EXACT [] synonym: "TDT" EXACT [] synonym: "terminal addition enzyme" EXACT [] synonym: "terminal deoxynucleotidyltransferase" EXACT [] synonym: "terminal transferase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007152 name: eosinophil peroxidase namespace: protein def: "A protein that is a translation product of the human EPX gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "EPER" RELATED [] synonym: "EPO" BROAD [] synonym: "EPP" RELATED [] synonym: "EPX" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007431 name: high affinity immunoglobulin epsilon receptor subunit alpha namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Fc-epsilon RI-alpha" EXACT [] synonym: "FCE1A" RELATED [] synonym: "FCER1A" EXACT [] synonym: "FcERI" RELATED [] synonym: "IgE Fc receptor subunit alpha" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000007597 name: proto-oncogene c-Fos namespace: protein def: "A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "cellular oncogene fos" EXACT [] synonym: "FOS" EXACT [] synonym: "G0/G1 switch regulatory protein 7" EXACT [] synonym: "G0S7" RELATED [] synonym: "proto-oncogene protein c-fos" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007857 name: erythroid transcription factor namespace: protein def: "A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Eryf1" EXACT [] synonym: "GATA-1" EXACT [] synonym: "GATA-binding factor 1" EXACT [] synonym: "GATA1" EXACT [] synonym: "GF-1" RELATED [] synonym: "GF1" RELATED [] synonym: "NF-E1 DNA-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007858 name: endothelial transcription factor GATA-2 namespace: protein def: "A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "GATA-binding protein 2" EXACT [] synonym: "GATA2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007939 name: glial fibrillary acidic protein namespace: protein def: "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "GFAP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008467 name: hemoglobin subunit zeta namespace: protein def: "A protein that is a translation product of the human HBZ gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "alpha-like embryonic globin chain x" EXACT [] synonym: "Hba-x" RELATED [] synonym: "HBAZ" EXACT [] synonym: "HBZ" EXACT [] synonym: "Hbz1" RELATED [] synonym: "HBZ2" RELATED [] synonym: "hemoglobin zeta chain" EXACT [] synonym: "zeta-globin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008857 name: hemoglobin subunit beta-1 namespace: protein def: "A protein that is a translation product of the mouse Hbb-b1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "beta-1-globin" EXACT [] synonym: "Hbb-b1" EXACT [] synonym: "hemoglobin beta-1 chain" EXACT [] synonym: "hemoglobin beta-major chain" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008982 name: interleukin-17 receptor B namespace: protein def: "A protein that is a translation product of the human IL17RB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CRL4" RELATED [] synonym: "cytokine receptor-like 4" EXACT [] synonym: "EVI27" RELATED [] synonym: "IL-17 receptor B" EXACT [] synonym: "IL-17 receptor homolog 1" EXACT [] synonym: "IL-17B receptor" EXACT [] synonym: "IL-17ER" EXACT [] synonym: "IL-17RB" EXACT [] synonym: "IL-17Rh1" EXACT [] synonym: "IL17BR" RELATED [] synonym: "IL17RB" EXACT [] synonym: "IL17Rh1" EXACT [] synonym: "interleukin-17B receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008994 name: interleukin-1 receptor-like 1 namespace: protein def: "A protein that is a translation product of the human IL1RL1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "DER4" RELATED [] synonym: "IL1RL1" EXACT [] synonym: "Ly84" RELATED [] synonym: "lymphocyte antigen 84" EXACT [] synonym: "protein ST2" EXACT [] synonym: "protein T1" EXACT [] synonym: "ST2" RELATED [] synonym: "Ste2" RELATED [] synonym: "T1" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000009127 name: integrin alpha-IIb namespace: protein def: "An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD41" EXACT [] synonym: "GP2B" RELATED [] synonym: "GPalpha IIb" EXACT [] synonym: "GPIIb" EXACT [] synonym: "ITGA2B" EXACT [] synonym: "ITGAB" RELATED [] synonym: "platelet membrane glycoprotein IIb" EXACT [] is_a: PR:000025797 ! integrin alpha lacking A domain [Term] id: PR:000009129 name: integrin alpha-4 namespace: protein def: "An integrin alpha lacking A domain that is a translation product of the human ITGA4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "CD49 antigen-like family member D" EXACT [] synonym: "CD49d" EXACT [] synonym: "integrin alpha-IV" EXACT [] synonym: "ITGA4" EXACT [] synonym: "LPAM subunit alpha" EXACT [] synonym: "lymphocyte Peyer patch adhesion molecules subunit alpha" EXACT [] synonym: "VLA-4 subunit alpha" EXACT [] is_a: PR:000025797 ! integrin alpha lacking A domain [Term] id: PR:000009143 name: integrin beta-7 namespace: protein def: "An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Gut homing receptor beta subunit" EXACT [] synonym: "integrin beta-P" EXACT [] synonym: "ITGB7" EXACT [] synonym: "M290 IEL antigen" EXACT [] is_a: PR:000001861 ! integrin beta [Term] id: PR:000009616 name: T-cell surface glycoprotein YE1/48 namespace: protein def: "A protein that is a translation product of the mouse Klra1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Klra1" EXACT [] synonym: "Ly-49" RELATED [] synonym: "ly-49a" EXACT [] synonym: "Ly49" RELATED [] synonym: "Ly49A" RELATED [] synonym: "lymphocyte antigen 49a" EXACT [] synonym: "T lymphocyte antigen A1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009618 name: killer cell lectin-like receptor 3 namespace: protein def: "A protein that is a translation product of the mouse Klra3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "5E6" EXACT [] synonym: "Klra3" EXACT [] synonym: "ly-49c" EXACT [] synonym: "Ly49C" RELATED [] synonym: "lymphocyte antigen 49c" EXACT [] synonym: "T-cell surface glycoprotein Ly-49C" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009619 name: killer cell lectin-like receptor 4 namespace: protein def: "A protein that is a translation product of the mouse Klra4 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Klra4" EXACT [] synonym: "ly-49d" EXACT [] synonym: "Ly49-d" RELATED [] synonym: "Ly49d" RELATED [] synonym: "lymphocyte antigen 49d" EXACT [] synonym: "T-cell surface glycoprotein Ly-49D" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009623 name: killer cell lectin-like receptor 8 namespace: protein def: "A protein that is a translation product of the mouse Klra8 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Klra8" EXACT [] synonym: "ly-49h" EXACT [] synonym: "Ly49-h" RELATED [] synonym: "Ly49H" RELATED [] synonym: "lymphocyte antigen 49h" EXACT [] synonym: "T-cell surface glycoprotein Ly-49H" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009725 name: neutrophil gelatinase-associated lipocalin namespace: protein def: "A protein that is a translation product of the human LCN2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "25 kDa alpha-2-microglobulin-related subunit of MMP-9" EXACT [] synonym: "HNL" RELATED [] synonym: "LCN2" EXACT [] synonym: "lipocalin-2" EXACT [] synonym: "NGAL" EXACT [] synonym: "oncogene 24p3" EXACT [] synonym: "p25" RELATED [] synonym: "SV-40-induced 24P3 protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009766 name: galectin-1 namespace: protein def: "A protein that is a translation product of the human LGALS1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "14 kDa laminin-binding protein" EXACT [] synonym: "14 kDa lectin" EXACT [] synonym: "beta-galactoside-binding lectin L-14-I" EXACT [] synonym: "gal-1" EXACT [] synonym: "galaptin" EXACT [] synonym: "Gbp" RELATED [] synonym: "HBL" EXACT [] synonym: "HLBP14" EXACT [] synonym: "HPL" EXACT [] synonym: "lactose-binding lectin 1" EXACT [] synonym: "lectin galactoside-binding soluble 1" EXACT [] synonym: "LGALS1" EXACT [] synonym: "putative MAPK-activating protein PM12" EXACT [] synonym: "S-Lac lectin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009978 name: lactotransferrin namespace: protein def: "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "lactoferrin" EXACT [] synonym: "LF" RELATED [] synonym: "LTF" EXACT [] synonym: "talalactoferrin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010329 name: tyrosine-protein kinase Mer namespace: protein def: "A protein that is a translation product of the human MERTK gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "MER" RELATED [] synonym: "MERTK" EXACT [] synonym: "proto-oncogene c-Mer" EXACT [] synonym: "proto-oncogene tyrosine-protein kinase MER" EXACT [] synonym: "receptor tyrosine kinase MerTK" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010543 name: myeloperoxidase namespace: protein def: "A protein that is a translation product of the human MPO gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "MPO" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010799 name: myb proto-oncogene protein namespace: protein def: "A protein that is a translation product of the human MYB gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "MYB" EXACT [] synonym: "proto-oncogene c-Myb" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011178 name: nuclear factor NF-kappa-B p100 subunit namespace: protein def: "A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "DNA-binding factor KBF2" EXACT [] synonym: "H2TF1" EXACT [] synonym: "lymphocyte translocation chromosome 10 protein" EXACT [] synonym: "lyt10" EXACT [] synonym: "NFKB2" EXACT [] synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2" EXACT [] synonym: "oncogene Lyt-10" EXACT [] is_a: PR:000001753 ! transcription factor NF-kappa-B subunit [Term] id: PR:000013206 name: bone marrow proteoglycan namespace: protein def: "A protein that is a translation product of the human PRG2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. synonym: "BMPG" EXACT [] synonym: "MBP" RELATED [] synonym: "Mbp-1" RELATED [] synonym: "PRG2" EXACT [] synonym: "proteoglycan 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000014046 name: non-secretory ribonuclease namespace: protein def: "A protein that is a translation product of the human RNASE2 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "Ear4" RELATED [] synonym: "EDN" RELATED [] synonym: "eosinophil cationic-type ribonuclease 4" EXACT [] synonym: "eosinophil-derived neurotoxin" EXACT [] synonym: "MR-4" EXACT [] synonym: "ribonuclease 2" EXACT [] synonym: "ribonuclease US" EXACT [] synonym: "RNase 2" EXACT [] synonym: "RNase UpI-2" EXACT [] synonym: "RNASE2" EXACT [] synonym: "RNS2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000014047 name: eosinophil cationic protein namespace: protein def: "A protein that is a translation product of the human RNASE3 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "ECP" EXACT [] synonym: "ribonuclease 3" RELATED [] synonym: "RNase 3" EXACT [] synonym: "RNASE3" EXACT [] synonym: "RNS3" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000014362 name: runt-related transcription factor 1 namespace: protein def: "A protein that is a translation product of the human RUNX1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "acute myeloid leukemia 1 protein" EXACT [] synonym: "AML1" RELATED [] synonym: "CBF-alpha-2" EXACT [] synonym: "CBFA2" RELATED [] synonym: "core-binding factor subunit alpha-2" EXACT [] synonym: "oncogene AML-1" EXACT [] synonym: "PEA2-alpha B" EXACT [] synonym: "PEBP2-alpha B" EXACT [] synonym: "Pebp2ab" RELATED [] synonym: "polyomavirus enhancer-binding protein 2 alpha B subunit" EXACT [] synonym: "RUNX1" EXACT [] synonym: "SL3-3 enhancer factor 1 alpha B subunit" EXACT [] synonym: "SL3/AKV core-binding factor alpha B subunit" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016043 name: T-cell acute lymphocytic leukemia protein 1 namespace: protein def: "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "bHLHa17" EXACT [] synonym: "class A basic helix-loop-helix protein 17" EXACT [] synonym: "SCL" RELATED [] synonym: "stem cell protein" EXACT [] synonym: "T-cell leukemia/lymphoma protein 5" EXACT [] synonym: "TAL-1" EXACT [] synonym: "TAL1" EXACT [] synonym: "TCL5" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000016401 name: transmembrane emp24 domain-containing protein 1 namespace: protein def: "A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof." [] comment: Category=gene. Requested by=CL. synonym: "IL1RL1L" RELATED [] synonym: "IL1RL1LG" RELATED [] synonym: "interleukin-1 receptor-like 1 ligand" EXACT [] synonym: "putative T1/ST2 receptor-binding protein" EXACT [] synonym: "TMED1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000018263 name: amino acid chain namespace: protein def: "A molecular entity that is a polymer of amino acids linked by peptide bonds." [] synonym: "peptide" NARROW [] synonym: "polypeptide" NARROW [] [Term] id: PR:000018264 name: proteolytic cleavage product namespace: protein def: "An amino acid chain produced as the result of peptide bond cleavage of a longer amino acid chain." [] synonym: "peptide" NARROW [] synonym: "polypeptide" NARROW [] is_a: PR:000018263 ! amino acid chain [Term] id: PR:000018311 name: integrin alpha-E proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from integrin alpha-E." [] comment: Category=modification. synonym: "ITGAE/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018335 name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." [] comment: Category=modification. synonym: "CD8A/SigPep-" EXACT [] is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: PR:000018337 name: T-cell surface glycoprotein CD8 beta chain, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed." [] comment: Category=modification. synonym: "CD8B1/SigPep-" EXACT [] is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain [Term] id: PR:000018381 name: CD48 molecule proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from CD48 molecule." [] comment: Category=modification. synonym: "CD48/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018390 name: L-selectin proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from L-selectin." [] comment: Category=modification. synonym: "SELL/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018406 name: carcinoembryonic antigen-related cell adhesion molecule 8 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from carcinoembryonic antigen-related cell adhesion molecule 8." [] comment: Category=modification. synonym: "CEACAM8/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018481 name: epithelial cadherin proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from epithelial cadherin." [] comment: Category=modification. synonym: "CDH1/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018524 name: 5'-nucleotidase proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from 5'-nucleotidase." [] comment: Category=modification. synonym: "NT5E/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018546 name: Thy-1 membrane glycoprotein proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from Thy-1 membrane glycoprotein." [] comment: Category=modification. synonym: "THY1/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018547 name: cathepsin K proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from cathepsin K." [] comment: Category=modification. synonym: "CTSK/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018568 name: low affinity immunoglobulin epsilon Fc receptor proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from low affinity immunoglobulin epsilon Fc receptor." [] comment: Category=modification. synonym: "FCER2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018575 name: CD14 molecule proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from CD14 molecule." [] comment: Category=modification. synonym: "CD14/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018591 name: platelet glycoprotein Ib alpha chain proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from platelet glycoprotein Ib alpha chain." [] comment: Category=modification. synonym: "GP1BA/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018594 name: scavenger receptor cysteine-rich type 1 protein M130 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from scavenger receptor cysteine-rich type 1 protein M130." [] comment: Category=modification. synonym: "CD163/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018603 name: transferrin receptor protein 1 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from transferrin receptor protein 1." [] comment: Category=modification. synonym: "TFRC/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000018606 name: tumor necrosis factor ligand superfamily member 5 proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from tumor necrosis factor ligand superfamily member 5." [] comment: Category=modification. synonym: "CD40LG/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000019802 name: eosinophil peroxidase proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from eosinophil peroxidase." [] comment: Category=modification. synonym: "EPX/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020329 name: integrin alpha-IIb proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from integrin alpha-IIb." [] comment: Category=modification. synonym: "ITGA2B/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020497 name: lactotransferrin proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from lactotransferrin." [] comment: Category=modification. synonym: "LTF/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020631 name: myeloperoxidase proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from myeloperoxidase." [] comment: Category=modification. synonym: "MPO/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000020735 name: nuclear factor NF-kappa-B p100 subunit proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from nuclear factor NF-kappa-B p100 subunit." [] comment: Category=modification. synonym: "NFKB2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000021081 name: bone marrow proteoglycan, signal peptide removed form namespace: protein def: "A bone marrow proteoglycan that has had the signal peptide removed." [] comment: Category=modification. synonym: "PRG2/SigPep-" EXACT [] is_a: PR:000013206 ! bone marrow proteoglycan [Term] id: PR:000021082 name: bone marrow proteoglycan proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from bone marrow proteoglycan." [] comment: Category=modification. synonym: "PRG2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000022003 name: bone marrow proteoglycan isoform 1 namespace: protein def: "A bone marrow proteoglycan that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P13727-1 or a 1:1 ortholog thereof." [] comment: Category=sequence. synonym: "PRG2/iso:1" EXACT [] is_a: PR:000013206 ! bone marrow proteoglycan [Term] id: PR:000022006 name: eosinophil granule major basic protein namespace: protein def: "A bone marrow proteoglycan proteolytic cleavage product that derives from bone marrow proteoglycan isoform 1, signal peptide removed form that has had the acidic propeptide removed." [] comment: Category=modification. Requested by=CL. is_a: PR:000021082 ! bone marrow proteoglycan proteolytic cleavage product [Term] id: PR:000025402 name: T cell receptor co-receptor CD8 namespace: protein def: "A protein complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." [] comment: Category=complex. Requested by=CL. synonym: "CD8alphabeta" EXACT [] synonym: "TCR co-receptor CD8" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: PR:000025403 name: T-cell surface glycoprotein CD8 alpha chain isoform 1 namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." [] comment: Category=sequence. Requested by=CL. synonym: "CD8A/iso:1" EXACT [] synonym: "mCD8alpha" EXACT [] is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: PR:000025405 name: T-cell surface glycoprotein CD8 beta chain isoform 1 namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof." [] comment: Category=sequence. synonym: "CD8B1/iso:1" EXACT [] synonym: "CD8beta isoform M-1" EXACT [] is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain [Term] id: PR:000025406 name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." [] comment: Category=modification. synonym: "CD8A/iso:1/SigPep-" EXACT [] is_a: PR:000018335 ! T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form is_a: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 [Term] id: PR:000025407 name: T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form." [] comment: Category=modification. synonym: "CD8B1/iso:1/SigPep-" EXACT [] is_a: PR:000018337 ! T-cell surface glycoprotein CD8 beta chain, signal peptide removed form is_a: PR:000025405 ! T-cell surface glycoprotein CD8 beta chain isoform 1 [Term] id: PR:000025408 name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that has been post-translationally modified to include at least one glycosylated residue." [] comment: Category=modification. synonym: "CD8A/iso:1/SigPep-/GlycoRes+" EXACT [] is_a: PR:000025406 ! T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form is_a: PR:000037069 ! glycoprotein [Term] id: PR:000025409 name: T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed glycosylated form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that has been post-translationally modified to include at least one glycosylated residue." [] comment: Category=modification. synonym: "CD8B1/iso:1/SigPep-/GlycoRes+" EXACT [] is_a: PR:000025407 ! T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form is_a: PR:000037069 ! glycoprotein [Term] id: PR:000025455 name: CD2 molecule proteolytic cleavage product namespace: protein def: "A proteolytic cleavage product that is derived from CD2 molecule." [] comment: Category=modification. synonym: "CD2/ClvPrd" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000025466 name: bone marrow proteoglycan isoform 1, signal peptide removed form namespace: protein def: "A bone marrow proteoglycan isoform 1 that has had the signal peptide removed." [] comment: Category=modification. synonym: "PRG2/iso:1/SigPep-" EXACT [] is_a: PR:000021081 ! bone marrow proteoglycan, signal peptide removed form is_a: PR:000022003 ! bone marrow proteoglycan isoform 1 [Term] id: PR:000025796 name: integrin alpha namespace: protein def: "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." [] comment: Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. is_a: PR:000000001 ! protein [Term] id: PR:000025797 name: integrin alpha lacking A domain namespace: protein def: "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." [] comment: Category=family. xref: PIRSF:PIRSF005666 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000037069 name: glycoprotein namespace: protein def: "A protein that contains at least one glycosylated residue." [] comment: Category=modification. synonym: "glycated protein" EXACT [] synonym: "glycosylated protein" EXACT [] synonym: "Prot/GlycoRes+" EXACT [] is_a: PR:000000001 ! protein [Term] id: UBERON:0000002 name: uterine cervix synonym: "canalis cervicis uteri" EXACT [] synonym: "caudal segment of uterus" EXACT [] synonym: "cervical canal" RELATED [] synonym: "cervical canal of uterus" EXACT [] synonym: "cervix" BROAD [] synonym: "cervix of uterus" RELATED [] synonym: "cervix uteri" EXACT [] synonym: "neck of uterus" EXACT [] synonym: "uterine cervix" EXACT [] is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0000006 name: islet of Langerhans synonym: "island of Langerhans" RELATED [] synonym: "island of pancreas" RELATED [] synonym: "islets of langerhans" RELATED [] synonym: "pancreatic insula" EXACT [] synonym: "pancreatic islet" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0034922 ! cell cluster [Term] id: UBERON:0000007 name: pituitary gland synonym: "glandula pituitaria" EXACT [] synonym: "Hp" BROAD [] synonym: "hypophysis" RELATED [] synonym: "hypophysis cerebri" RELATED [] synonym: "pituitary" EXACT [] synonym: "pituitary body" EXACT [] is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010133 ! neuroendocrine gland is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0000010 name: peripheral nervous system synonym: "lateral part of the basal amygdalar nucleus" RELATED [] synonym: "lateral part of the basolateral nucleus" RELATED [] synonym: "nucleus amygdalae basalis, pars lateralis" RELATED [] synonym: "nucleus amygdaloideus basalis, pars lateralis magnocellularis" RELATED [] synonym: "nucleus basalis lateralis amygdalae" RELATED [] synonym: "pars peripherica; systema nervosum periphericum" RELATED [] synonym: "PNS" RELATED [] is_a: UBERON:0011216 ! organ system subdivision [Term] id: UBERON:0000014 name: zone of skin synonym: "portion of skin" EXACT [] synonym: "region of skin" EXACT [] synonym: "skin" EXACT [] synonym: "skin region" EXACT [] synonym: "skin zone" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0000017 name: exocrine pancreas synonym: "exocrine component of pancreas" RELATED [] synonym: "exocrine pancreas" EXACT [] synonym: "exocrine part of pancreas" RELATED [] synonym: "pars exocrina pancreatis" EXACT [] is_a: UBERON:0000409 ! serous gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005177 ! trunk region element [Term] id: UBERON:0000018 name: compound eye synonym: "adult compound eye" RELATED [] synonym: "faceted eye" RELATED [] synonym: "Facettenauge" RELATED [] synonym: "insect eye" RELATED [] synonym: "Komplexauge" RELATED [] synonym: "zusammengesetztes Auge" RELATED [] is_a: UBERON:0015165 ! multi-unit eye [Term] id: UBERON:0000019 name: camera-type eye synonym: "camera-type eye plus associated structures" RELATED [] synonym: "eye" BROAD [] synonym: "eyes" RELATED [] synonym: "orbital part of face" RELATED [] synonym: "orbital region" RELATED [] synonym: "regio orbitalis" EXACT [] synonym: "vertebrate eye" NARROW [] is_a: UBERON:0000047 ! simple eye is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0000020 name: sense organ synonym: "organ of sense organ system" EXACT [] synonym: "organ of sensory organ system" EXACT [] synonym: "organ of sensory system" EXACT [] synonym: "sense organ system organ" EXACT [] synonym: "sensillum" NARROW [] synonym: "sensor" RELATED [] synonym: "sensory organ" EXACT [] synonym: "sensory organ system organ" EXACT [] synonym: "sensory system organ" EXACT [] synonym: "Sinnesorgan" RELATED [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0000025 name: tube synonym: "anatomical tube" EXACT [] synonym: "duct" NARROW [] is_a: UBERON:0004111 ! anatomical conduit [Term] id: UBERON:0000026 name: appendage synonym: "appendages" RELATED [] synonym: "extremitaet" RELATED [] synonym: "extremity" RELATED [] synonym: "limbs/digits/tail" RELATED [] is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0000029 name: lymph node synonym: "lymph gland" RELATED [] synonym: "nodus lymphaticus" RELATED [] is_a: UBERON:0005057 ! immune organ [Term] id: UBERON:0000030 name: lamina propria synonym: "lamina propria mucosa" EXACT [] synonym: "lamina propria mucosae" EXACT [] synonym: "tunica propria" RELATED [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0000042 name: serous membrane synonym: "serosa" RELATED [] synonym: "tunica serosa" EXACT [] synonym: "wall of serous sac" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004457 ! cavity lining [Term] id: UBERON:0000043 name: tendon synonym: "sinew" RELATED [] synonym: "tendo" RELATED [] is_a: UBERON:0007846 ! dense regular connective tissue [Term] id: UBERON:0000044 name: dorsal root ganglion synonym: "dorsal root ganglia" RELATED [] synonym: "dorsal root ganglion" EXACT [] synonym: "DRG" RELATED [] synonym: "ganglion of dorsal root" EXACT [] synonym: "ganglion sensorium nervi spinalis" RELATED [] synonym: "ganglion spinale" RELATED [] synonym: "ganglion spinalis" EXACT [] synonym: "posterior root ganglion" RELATED [] synonym: "spinal ganglion" EXACT [] is_a: UBERON:0001800 ! sensory ganglion is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0000045 name: ganglion synonym: "ganglia" RELATED [] synonym: "neural ganglion" RELATED [] is_a: UBERON:0034922 ! cell cluster [Term] id: UBERON:0000047 name: simple eye is_a: UBERON:0000970 ! eye [Term] id: UBERON:0000054 name: macula synonym: "acoustic macula" RELATED [] synonym: "acoustic maculae" RELATED [] synonym: "macula" EXACT [] synonym: "maculae" EXACT [] synonym: "sensory macula" EXACT [] synonym: "sensory patch" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0000055 name: vessel is_a: UBERON:0004111 ! anatomical conduit [Term] id: UBERON:0000056 name: ureter synonym: "metanephric duct" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0006555 ! excretory tube is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0000057 name: urethra is_a: UBERON:0000062 ! organ is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0000058 name: duct synonym: "anatomical duct" EXACT [] synonym: "ducts" RELATED [] synonym: "exocrine duct" NARROW [] synonym: "exocrine gland duct" NARROW [] is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0000059 name: large intestine synonym: "intestinum crassum" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0000060 name: anatomical wall synonym: "organ wall" RELATED [] synonym: "wall" BROAD [] synonym: "wall of organ" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000061 name: anatomical structure synonym: "biological structure" EXACT [] synonym: "connected biological structure" EXACT [] is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0000062 name: organ synonym: "anatomical unit" RELATED [] synonym: "body organ" RELATED [] synonym: "element" RELATED [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000063 name: organ subunit synonym: "organ region with fixed fiat boundary" RELATED [] synonym: "organ segment" RELATED [] synonym: "segment of organ" RELATED [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000064 name: organ part synonym: "cardinal organ part" EXACT [] synonym: "regional part of organ" RELATED [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000065 name: respiratory tract is_a: UBERON:0001005 ! respiratory airway is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0000072 name: proximo-distal subdivision of respiratory tract synonym: "respiratory tract" RELATED [] synonym: "subdivision of respiratory tract" RELATED [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube [Term] id: UBERON:0000073 name: regional part of nervous system synonym: "part of nervous system" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure [Term] id: UBERON:0000074 name: renal glomerulus synonym: "glomerular capillary tuft" RELATED [] synonym: "glomerular tuft" RELATED [] synonym: "glomerulus" BROAD [] synonym: "glomerulus renis" RELATED [] synonym: "malphigian glomerulus" RELATED [] synonym: "renal corpuscle" RELATED [] synonym: "renal glomeruli" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0000075 name: subdivision of skeletal system synonym: "skeletal system part" RELATED [] synonym: "skeletal system subdivision" EXACT [] is_a: UBERON:0011216 ! organ system subdivision [Term] id: UBERON:0000077 name: mixed endoderm/mesoderm-derived structure is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0000078 name: mixed ectoderm/mesoderm/endoderm-derived structure is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0000080 name: mesonephros synonym: "amphibian adult kidney" RELATED [] synonym: "corpus Wolffi" RELATED [] synonym: "mesonephric kidney" EXACT [] synonym: "mesonephroi" EXACT [] synonym: "middle kidney" RELATED [] synonym: "opisthonephros" RELATED [] synonym: "opisto nephros" RELATED [] synonym: "opistonephros" RELATED [] synonym: "Wolffian body" EXACT [] is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0000081 name: metanephros synonym: "definite kidney" RELATED [] synonym: "definitive kidney" RELATED [] synonym: "hind kidney" RELATED [] synonym: "metanephric kidney" RELATED [] synonym: "metanephron" EXACT [] is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0000083 name: mesonephric tubule synonym: "renal tubules" RELATED [] synonym: "tubuli mesonephrici" RELATED [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005103 ! mesonephric epithelium is_a: UBERON:0006555 ! excretory tube [Term] id: UBERON:0000085 name: morula synonym: "morula (2-16 cells)" RELATED [] is_a: UBERON:0000922 ! embryo [Term] id: UBERON:0000087 name: inner cell mass synonym: "embryoblast" RELATED [] synonym: "embryoblastus; massa cellularis interna; pluriblastus senior" RELATED [] synonym: "ICM" RELATED [] synonym: "pluriblast" RELATED [] is_a: UBERON:0002050 ! embryonic structure [Term] id: UBERON:0000094 name: membrane organ synonym: "membrane" BROAD [] synonym: "membrane of organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0000095 name: cardiac neural crest synonym: "cardiac neural crest complex" RELATED [] synonym: "complexus cristae neuralis cardiacus" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue [Term] id: UBERON:0000102 name: lung vasculature synonym: "lung vascular network" EXACT [] synonym: "pulmonary vasculature" EXACT [] synonym: "vascular network of lung" EXACT [] synonym: "vasculature of lung" EXACT [] is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ [Term] id: UBERON:0000115 name: lung epithelium synonym: "epithelial tissue of lung" EXACT [] synonym: "epithelium of lung" EXACT [] synonym: "lung epithelial tissue" EXACT [] synonym: "pulmonary epithelium" RELATED [] is_a: UBERON:0004815 ! lower respiratory tract epithelium [Term] id: UBERON:0000117 name: respiratory tube synonym: "respiratory conducting tube" NARROW [] synonym: "segment of tracheobronchial tree" EXACT [] synonym: "segment of tracheobronchial tree" NARROW [] synonym: "tracheobronchial tree segment" NARROW [] is_a: UBERON:0000025 ! tube is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0000119 name: cell layer synonym: "cell sheath" RELATED [] synonym: "layer of cells" EXACT [] synonym: "sheath of cells" RELATED [] is_a: UBERON:0000957 ! lamina [Term] id: UBERON:0000121 name: perineurium is_a: UBERON:0011822 ! dense irregular connective tissue [Term] id: UBERON:0000122 name: neuron projection bundle synonym: "funiculus" EXACT [] synonym: "nerve fiber bundle" EXACT [] synonym: "neural fiber bundle" EXACT [] is_a: UBERON:0005162 ! multi cell part structure [Term] id: UBERON:0000125 name: neural nucleus synonym: "nervous system nucleus" EXACT [] synonym: "neuraxis nucleus" EXACT [] synonym: "neuronal nucleus" EXACT [] synonym: "nucleus" BROAD [] synonym: "nucleus of CNS" EXACT [] synonym: "nucleus of neuraxis" RELATED [] is_a: UBERON:0011215 ! central nervous system cell part cluster [Term] id: UBERON:0000158 name: membranous layer synonym: "membrane" BROAD [] synonym: "membranous organ component" EXACT [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0000159 name: anal canal synonym: "anal canal" EXACT [] synonym: "anal canal viewed anatomically" EXACT [] synonym: "anal pad" RELATED [] synonym: "anatomical anal canal" EXACT [] synonym: "anus" RELATED [] synonym: "canalis analis" RELATED [] synonym: "cloaca" RELATED [] synonym: "cloacal chamber" RELATED [] synonym: "mesenteron" RELATED [] synonym: "pars analis recti" RELATED [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0000160 name: intestine synonym: "bowel" EXACT [] synonym: "intestinal tract" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0000168 name: proximal-distal subdivision of colon synonym: "segment of colon" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0000171 name: respiration organ synonym: "apparatus respiratorius organ" EXACT [] synonym: "breathing organ" EXACT [] synonym: "gas exchange organ" RELATED [] synonym: "organ of apparatus respiratorius" EXACT [] synonym: "organ of respiratory system" EXACT [] synonym: "respiratory organ" EXACT [] synonym: "respiratory system organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0000173 name: amniotic fluid synonym: "acqua amnii" RELATED [] synonym: "liquor amnii" RELATED [] is_a: UBERON:0000463 ! organism substance [Term] id: UBERON:0000178 name: blood synonym: "portion of blood" EXACT [] synonym: "vertebrate blood" EXACT [] synonym: "whole blood" RELATED [] is_a: UBERON:0000179 ! haemolymphatic fluid [Term] id: UBERON:0000179 name: haemolymphatic fluid synonym: "blood or blood analog" RELATED [] synonym: "circulating fluid" RELATED [] is_a: UBERON:0006314 ! bodily fluid [Term] id: UBERON:0000211 name: ligament synonym: "ligament organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0000305 name: amnion is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane [Term] id: UBERON:0000310 name: breast synonym: "mamma" RELATED [] synonym: "mammary part of chest" EXACT [] synonym: "mammary region" EXACT [] is_a: UBERON:0034929 ! external soft tissue zone [Term] id: UBERON:0000325 name: gastric gland is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003294 ! gland of foregut [Term] id: UBERON:0000333 name: intestinal gland synonym: "bowel mucosa gland" EXACT [] synonym: "bowel mucosa of organ gland" EXACT [] synonym: "bowel mucous membrane gland" EXACT [] synonym: "bowel organ mucosa gland" EXACT [] synonym: "gland of bowel mucosa" EXACT [] synonym: "gland of bowel mucosa of organ" EXACT [] synonym: "gland of bowel mucous membrane" EXACT [] synonym: "gland of bowel organ mucosa" EXACT [] synonym: "gland of intestinal mucosa" EXACT [] synonym: "gland of intestine mucosa" EXACT [] synonym: "gland of intestine mucosa of organ" EXACT [] synonym: "gland of intestine mucous membrane" EXACT [] synonym: "gland of intestine organ mucosa" EXACT [] synonym: "gland of mucosa of bowel" EXACT [] synonym: "gland of mucosa of intestine" EXACT [] synonym: "gland of mucosa of organ of bowel" EXACT [] synonym: "gland of mucosa of organ of intestine" EXACT [] synonym: "gland of mucous membrane of bowel" EXACT [] synonym: "gland of mucous membrane of intestine" EXACT [] synonym: "gland of organ mucosa of bowel" EXACT [] synonym: "gland of organ mucosa of intestine" EXACT [] synonym: "glandula intestinalis" EXACT [] synonym: "glandulae intestinales" RELATED [] synonym: "intestinal mucosa gland" EXACT [] synonym: "intestine mucosa gland" EXACT [] synonym: "intestine mucosa of organ gland" EXACT [] synonym: "intestine mucous membrane gland" EXACT [] synonym: "intestine organ mucosa gland" EXACT [] synonym: "mucosa of bowel gland" EXACT [] synonym: "mucosa of intestine gland" EXACT [] synonym: "mucosa of organ of bowel gland" EXACT [] synonym: "mucosa of organ of intestine gland" EXACT [] synonym: "mucous membrane of bowel gland" EXACT [] synonym: "mucous membrane of intestine gland" EXACT [] synonym: "organ mucosa of bowel gland" EXACT [] synonym: "organ mucosa of intestine gland" EXACT [] is_a: UBERON:0003408 ! gland of gut [Term] id: UBERON:0000344 name: mucosa synonym: "mucosa of organ" EXACT [] synonym: "mucosa of organ part" EXACT [] synonym: "mucosal region" EXACT [] synonym: "mucous membrane" EXACT [] synonym: "organ mucosa" EXACT [] synonym: "region of mucosa" RELATED [] synonym: "tunica mucosa" RELATED [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0000353 name: parenchyma is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000358 name: blastocyst synonym: "blastocystis" RELATED [] synonym: "blastula" RELATED [] is_a: UBERON:0002050 ! embryonic structure [Term] id: UBERON:0000362 name: renal medulla synonym: "kidney medulla" EXACT [] synonym: "medulla of kidney" EXACT [] synonym: "medulla renalis" EXACT [] synonym: "medullary pyramids" RELATED [] synonym: "pyramides renales" EXACT [] synonym: "renal marrow" RELATED [] synonym: "renal medullae" EXACT [] synonym: "renal medullae set" EXACT [] synonym: "renal pyramids" EXACT [] synonym: "renal pyramids set" EXACT [] is_a: UBERON:0000958 ! medulla of organ [Term] id: UBERON:0000365 name: urothelium synonym: "transitional epithelium" BROAD [] synonym: "uroepithelium" EXACT [] is_a: UBERON:0005910 ! transitional epithelium [Term] id: UBERON:0000369 name: corpus striatum synonym: "striate body" RELATED [] synonym: "striated body" RELATED [] is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0000376 name: hindlimb stylopod synonym: "femur" RELATED [] synonym: "hind limb stylopod" EXACT [] synonym: "hind limb stylopodium" EXACT [] synonym: "hind propodium" EXACT [] synonym: "hindlimb propodium" EXACT [] synonym: "hindlimb stylopod" EXACT [] synonym: "hindlimb stylopodium" EXACT [] synonym: "inferior member stylopod" EXACT [] synonym: "lower extremity stylopod" EXACT [] synonym: "proximal segment of free lower limb" EXACT [] synonym: "stylopod of hind limb" EXACT [] synonym: "stylopod of hindlimb" EXACT [] synonym: "stylopod of inferior member" EXACT [] synonym: "stylopod of lower extremity" EXACT [] synonym: "stylopod of lower limb" EXACT [] synonym: "thigh" EXACT [] synonym: "upper leg" EXACT [] is_a: UBERON:0002472 ! stylopod is_a: UBERON:0008784 ! lower limb segment [Term] id: UBERON:0000378 name: tongue muscle synonym: "muscle of tongue" EXACT [] synonym: "muscle organ of tongue" EXACT [] synonym: "musculi linguae" RELATED [] synonym: "skeletal muscle tissue of tongue" EXACT [] synonym: "tongue skeletal muscle" EXACT [] synonym: "tongue skeletal muscle tissue" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle is_a: UBERON:0013765 ! digestive system element union_of: UBERON:0001575 ! extrinsic muscle of tongue union_of: UBERON:0001576 ! intrinsic muscle of tongue [Term] id: UBERON:0000379 name: tracheal mucosa synonym: "mucosa of organ of trachea" EXACT [] synonym: "mucosa of organ of windpipe" EXACT [] synonym: "mucosa of trachea" EXACT [] synonym: "mucosa of windpipe" EXACT [] synonym: "Mucous membrane of trachea" EXACT [] synonym: "mucous membrane of trachea" EXACT [] synonym: "mucous membrane of windpipe" EXACT [] synonym: "organ mucosa of trachea" EXACT [] synonym: "organ mucosa of windpipe" EXACT [] synonym: "trachea mucosa" EXACT [] synonym: "trachea mucosa of organ" EXACT [] synonym: "trachea mucous membrane" EXACT [] synonym: "trachea organ mucosa" EXACT [] synonym: "Tracheal mucous membrane" EXACT [] synonym: "Tunica mucosa (tracheae)" EXACT [] synonym: "tunica mucosa tracheae" EXACT [] synonym: "windpipe mucosa" EXACT [] synonym: "windpipe mucosa of organ" EXACT [] synonym: "windpipe mucous membrane" EXACT [] synonym: "windpipe organ mucosa" EXACT [] is_a: UBERON:0004785 ! respiratory system mucosa [Term] id: UBERON:0000395 name: cochlear ganglion synonym: "cochlear part of vestibulocochlear ganglion" EXACT [] synonym: "Corti's ganglion" EXACT [] synonym: "ganglion cochlearis" RELATED [] synonym: "ganglion of Corti" EXACT [] synonym: "ganglion spirale" RELATED [] synonym: "ganglion spirale cochleae" RELATED [] synonym: "spiral ganglion" EXACT [] synonym: "spiral ganglion of cochlea" RELATED [] synonym: "vestibulocochlear ganglion cochlear component" RELATED [] synonym: "vestibulocochlear VIII ganglion cochlear component" EXACT [] is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0000397 name: colonic epithelium synonym: "colon epithelial tissue" EXACT [] synonym: "Colon epithelium" EXACT [] synonym: "colon epithelium" EXACT [] synonym: "epithelial tissue of colon" EXACT [] synonym: "epithelial tissue of large bowel" EXACT [] synonym: "epithelium of colon" EXACT [] synonym: "epithelium of large bowel" EXACT [] synonym: "large bowel epithelial tissue" EXACT [] synonym: "large bowel epithelium" EXACT [] synonym: "posterior intestine epithelium" EXACT [] is_a: UBERON:0001278 ! epithelium of large intestine [Term] id: UBERON:0000403 name: scalp synonym: "scalpus" RELATED [] is_a: UBERON:0034921 ! multi organ part structure [Term] id: UBERON:0000409 name: serous gland is_a: UBERON:0002365 ! exocrine gland [Term] id: UBERON:0000412 name: dermal papilla synonym: "dermal papilla cell" RELATED [] synonym: "dermal papillae" EXACT [] synonym: "DPC" RELATED [] synonym: "follicular papilla" EXACT [] synonym: "hair follicle dermal papilla" RELATED [] synonym: "hair papilla" RELATED [] synonym: "papilla corii" RELATED [] synonym: "papilla dermatis" RELATED [] synonym: "papilla dermis" RELATED [] synonym: "papilla of corium" RELATED [] synonym: "papillae dermis" RELATED [] synonym: "skin papilla" RELATED [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0000414 name: mucous gland synonym: "glandula mucosa" EXACT [] synonym: "muciparous gland" RELATED [] synonym: "mucous secreting gland" RELATED [] synonym: "mucus gland" RELATED [] synonym: "mucus-secreting gland" RELATED [] is_a: UBERON:0002365 ! exocrine gland [Term] id: UBERON:0000423 name: eccrine sweat gland synonym: "eccrine gland" RELATED [] synonym: "glandula sudorifera eccrina" EXACT [] synonym: "glandula sudorifera merocrina" EXACT [] synonym: "merocrine sweat gland" RELATED [] is_a: UBERON:0001820 ! sweat gland is_a: UBERON:0010243 ! merocrine gland [Term] id: UBERON:0000444 name: lymphoid follicle synonym: "folliculus lymphaticus" RELATED [] synonym: "lymphatic follicle" RELATED [] synonym: "lymphatic nodule" RELATED [] synonym: "lymphoid nodule" EXACT [] synonym: "nodular lymphoid tissue" EXACT [] synonym: "nodulus lymphaticus" RELATED [] synonym: "nodulus lymphoideus" RELATED [] is_a: UBERON:0001744 ! lymphoid tissue [Term] id: UBERON:0000458 name: endocervix is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0000463 name: organism substance synonym: "body fluid or substance" EXACT [] synonym: "body substance" EXACT [] synonym: "organism substance" EXACT [] synonym: "portion of body substance" EXACT [] is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0000464 name: anatomical space synonym: "lumen" BROAD [] synonym: "lumen space" EXACT [] synonym: "space" BROAD [] is_a: UBERON:0000466 ! immaterial anatomical entity [Term] id: UBERON:0000465 name: material anatomical entity is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000466 name: immaterial anatomical entity synonym: "immaterial physical anatomical entity" EXACT [] is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000467 name: anatomical system synonym: "body system" EXACT [] synonym: "connected anatomical system" EXACT [] synonym: "organ system" EXACT [] synonym: "system" BROAD [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0000468 name: multicellular organism synonym: "animal" NARROW [] synonym: "body" RELATED [] synonym: "Koerper" RELATED [] synonym: "multi-cellular organism" EXACT [] synonym: "organism" EXACT [] synonym: "whole body" RELATED [] synonym: "whole organism" EXACT [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000471 name: compound organ component is_a: UBERON:0000481 ! multi-tissue structure [Term] id: UBERON:0000473 name: testis synonym: "gonad of male genitalia" EXACT [] synonym: "gonad of male reproductive system" EXACT [] synonym: "male gonad" EXACT [] synonym: "orchis" RELATED [] synonym: "testes" RELATED [] synonym: "testicle" EXACT [] synonym: "testiculus" RELATED [] is_a: UBERON:0000991 ! gonad is_a: UBERON:0003135 ! male reproductive organ [Term] id: UBERON:0000475 name: organism subdivision synonym: "anatomic region" EXACT [] synonym: "body part" RELATED [] synonym: "body region" RELATED [] synonym: "cardinal body part" RELATED [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000477 name: anatomical cluster is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000478 name: extraembryonic structure synonym: "extra-embryonic structure" EXACT [] synonym: "extraembryonic tissue" RELATED [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0000479 name: tissue synonym: "portion of tissue" EXACT [] synonym: "simple tissue" NARROW [] synonym: "tissue portion" EXACT [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000481 name: multi-tissue structure is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0000483 name: epithelium synonym: "epithelial tissue" EXACT [] synonym: "portion of epithelium" EXACT [] is_a: UBERON:0000479 ! tissue union_of: UBERON:0000486 ! multilaminar epithelium union_of: UBERON:0000490 ! unilaminar epithelium [Term] id: UBERON:0000484 name: simple cuboidal epithelium synonym: "epithelium simplex cuboideum" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010077 ! cuboidal epithelium [Term] id: UBERON:0000485 name: simple columnar epithelium synonym: "columnar epithelium" BROAD [] synonym: "columnar epithlium" BROAD [] synonym: "epithelium simplex columnare" EXACT [] synonym: "simple columnar epithelium" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium [Term] id: UBERON:0000486 name: multilaminar epithelium synonym: "laminated epithelium" RELATED [] synonym: "stratified epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000487 name: simple squamous epithelium synonym: "epithelium simplex squamosum" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium [Term] id: UBERON:0000488 name: atypical epithelium synonym: "heterogenous epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000489 name: cavitated compound organ synonym: "cavitated organ" EXACT [] is_a: UBERON:0003103 ! compound organ [Term] id: UBERON:0000490 name: unilaminar epithelium synonym: "simple epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000916 name: abdomen synonym: "abdominopelvic region" EXACT [] synonym: "abdominopelvis" EXACT [] synonym: "adult abdomen" RELATED [] synonym: "belly" RELATED [] synonym: "celiac region" RELATED [] is_a: UBERON:0009569 ! subdivision of trunk [Term] id: UBERON:0000922 name: embryo synonym: "developing organism" RELATED [] synonym: "developmental tissue" RELATED [] synonym: "embryonic organism" EXACT [] is_a: UBERON:0000468 ! multicellular organism [Term] id: UBERON:0000923 name: germ layer synonym: "embryonic germ layer" RELATED [] synonym: "embryonic germ layers" RELATED [] synonym: "embryonic tissue" BROAD [] synonym: "germinal layer" EXACT [] synonym: "primary germ layer" NARROW [] is_a: UBERON:0010316 ! germ layer / neural crest [Term] id: UBERON:0000924 name: ectoderm synonym: "embryonic ectoderm" EXACT [] is_a: UBERON:0000923 ! germ layer [Term] id: UBERON:0000925 name: endoderm synonym: "entoderm" RELATED [] is_a: UBERON:0000923 ! germ layer [Term] id: UBERON:0000926 name: mesoderm synonym: "embryonic mesoderm" RELATED [] synonym: "entire mesoderm" RELATED [] synonym: "mesodermal mantle" RELATED [] is_a: UBERON:0000923 ! germ layer [Term] id: UBERON:0000945 name: stomach synonym: "anterior intestine" RELATED [] synonym: "gaster" RELATED [] synonym: "mesenteron" RELATED [] synonym: "stomach chamber" NARROW [] synonym: "Ventricular" RELATED [] synonym: "ventriculus" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0010039 ! food storage organ [Term] id: UBERON:0000948 name: heart synonym: "branchial heart" NARROW [] synonym: "cardium" RELATED [] synonym: "chambered heart" EXACT [] synonym: "Herz@de" RELATED [] synonym: "vertebrate heart" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0007100 ! primary circulatory organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0000955 name: brain synonym: "encephalon" RELATED [] synonym: "suprasegmental levels of nervous system" RELATED [] synonym: "suprasegmental structures" RELATED [] synonym: "synganglion" RELATED [] synonym: "the brain" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0000956 name: cerebral cortex synonym: "brain cortex" RELATED [] synonym: "cortex cerebralis" RELATED [] synonym: "cortex cerebri" RELATED [] synonym: "cortex of cerebral hemisphere" EXACT [] synonym: "cortical plate (areas)" RELATED [] synonym: "cortical plate (CTXpl)" RELATED [] synonym: "pallium of the brain" RELATED [] is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 ! central nervous system gray matter layer [Term] id: UBERON:0000957 name: lamina synonym: "laminar tissue" EXACT [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0000958 name: medulla of organ synonym: "medulla" EXACT [] is_a: UBERON:0000471 ! compound organ component [Term] id: UBERON:0000964 name: cornea synonym: "cornea of camera-type eye" EXACT [] synonym: "tunica cornea" RELATED [] is_a: UBERON:0003102 ! surface structure is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0000965 name: lens of camera-type eye synonym: "camera-type eye lens" EXACT [] synonym: "crystalline lens" RELATED [] synonym: "eye lens" EXACT [] synonym: "lens" EXACT [] synonym: "lens crystallina" EXACT [] synonym: "ocular lens" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005389 ! transparent eye structure [Term] id: UBERON:0000966 name: retina synonym: "inner layer of eyeball" EXACT [] synonym: "Netzhaut" RELATED [] synonym: "retina of camera-type eye" EXACT [] synonym: "tunica interna of eyeball" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005388 ! photoreceptor array [Term] id: UBERON:0000970 name: eye synonym: "light-detecting organ" RELATED [] synonym: "visual apparatus" RELATED [] is_a: UBERON:0000020 ! sense organ [Term] id: UBERON:0000977 name: pleura synonym: "pleura" RELATED [] synonym: "pleural tissue" RELATED [] synonym: "wall of pleural sac" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure [Term] id: UBERON:0000981 name: femur synonym: "femoral bone" RELATED [] synonym: "mesomere 1 of pevlic appendage" RELATED [] synonym: "os femorale" RELATED [] synonym: "os femoris" RELATED [] synonym: "os longissimum" RELATED [] synonym: "proximal metapterygial mesomere of pelvic appendage" RELATED [] synonym: "proximal metapterygial mesomere of pelvic fin" RELATED [] synonym: "thigh bone" EXACT [] is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0003826 ! upper leg bone is_a: UBERON:0008202 ! bone of hip region is_a: UBERON:0015052 ! femur endochondral element [Term] id: UBERON:0000982 name: skeletal joint synonym: "articular joint" RELATED [] synonym: "articulation" BROAD [] synonym: "joint" BROAD [] is_a: UBERON:0004905 ! articulation union_of: UBERON:0002217 ! synovial joint union_of: UBERON:0011134 ! nonsynovial joint [Term] id: UBERON:0000991 name: gonad synonym: "gonada" EXACT [] is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0000992 name: female gonad synonym: "female organism genitalia gonad" EXACT [] synonym: "female organism genitalia gonada" EXACT [] synonym: "female organism reproductive system gonad" EXACT [] synonym: "female organism reproductive system gonada" EXACT [] synonym: "female reproductive system gonad" EXACT [] synonym: "female reproductive system gonada" EXACT [] synonym: "genitalia of female organism gonad" EXACT [] synonym: "genitalia of female organism gonada" EXACT [] synonym: "gonad of female organism genitalia" EXACT [] synonym: "gonad of female organism reproductive system" EXACT [] synonym: "gonad of female reproductive system" EXACT [] synonym: "gonad of genitalia of female organism" EXACT [] synonym: "gonad of reproductive system of female organism" EXACT [] synonym: "gonada of female organism genitalia" EXACT [] synonym: "gonada of female organism reproductive system" EXACT [] synonym: "gonada of female reproductive system" EXACT [] synonym: "gonada of genitalia of female organism" EXACT [] synonym: "gonada of reproductive system of female organism" EXACT [] synonym: "ovaries" RELATED [] synonym: "ovarium" RELATED [] synonym: "ovary" EXACT [] synonym: "ovum-producing ovary" EXACT [] synonym: "reproductive system of female organism gonad" EXACT [] synonym: "reproductive system of female organism gonada" EXACT [] is_a: UBERON:0000991 ! gonad is_a: UBERON:0003134 ! female reproductive organ [Term] id: UBERON:0000993 name: oviduct synonym: "female reproductive tracts" RELATED [] synonym: "ovarian duct" EXACT [] synonym: "ovarian tube" EXACT [] synonym: "tuba uterina" RELATED [] synonym: "tuba uterinae" RELATED [] synonym: "tubular parts of female reproductive system" RELATED [] synonym: "uterine tube" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0000995 name: uterus is_a: UBERON:0013515 ! subdivision of oviduct [Term] id: UBERON:0000996 name: vagina synonym: "distal oviductal region" RELATED [] synonym: "distal portion of oviduct" RELATED [] synonym: "vaginae" RELATED [] is_a: UBERON:0013515 ! subdivision of oviduct [Term] id: UBERON:0000998 name: seminal vesicle synonym: "glandula seminalis" RELATED [] synonym: "glandula vesiculosa" RELATED [] synonym: "gon_male_sves" RELATED [] synonym: "seminal gland" BROAD [] synonym: "vas efferens" RELATED [] synonym: "vesicula seminalis" RELATED [] synonym: "vesiculae seminales" RELATED [] synonym: "vesicular gland" RELATED [] synonym: "vesicular glands" RELATED [] synonym: "vesicular seminalis" RELATED [] synonym: "vesiculæ seminales" RELATED [] synonym: "vesiculæ seminales" RELATED [] is_a: UBERON:0006868 ! seminal fluid secreting gland [Term] id: UBERON:0001003 name: skin epidermis synonym: "epidermis" BROAD [] synonym: "skin" BROAD [] synonym: "vertebrate epidermis" EXACT [] is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure [Term] id: UBERON:0001004 name: respiratory system synonym: "apparatus respiratorius" EXACT [] synonym: "apparatus respiratorius" RELATED [] synonym: "Atmungssystem" RELATED [] synonym: "respiratory system" EXACT [] synonym: "systema respiratorium" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001005 name: respiratory airway synonym: "airway" BROAD [] synonym: "airways" BROAD [] is_a: UBERON:0003103 ! compound organ [Term] id: UBERON:0001008 name: renal system synonym: "excretory system" EXACT [] synonym: "renal or urinary system" RELATED [] synonym: "renal system" EXACT [] synonym: "renal/urinary system" RELATED [] synonym: "systema urinaria" EXACT [] synonym: "systema urinarium" EXACT [] synonym: "urinary system" EXACT [] synonym: "urinary tract" EXACT [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001013 name: adipose tissue synonym: "adipose" RELATED [] synonym: "bodyfat" RELATED [] synonym: "fat" EXACT [] synonym: "fat tissue" EXACT [] synonym: "fatty depot" RELATED [] synonym: "fatty tissue" EXACT [] is_a: UBERON:0011822 ! dense irregular connective tissue [Term] id: UBERON:0001016 name: nervous system synonym: "nerve net" NARROW [] synonym: "neurological system" EXACT [] synonym: "systema nervosum" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001017 name: central nervous system synonym: "cerebrospinal axis" NARROW [] synonym: "CNS" EXACT [] synonym: "neuraxis" RELATED [] synonym: "systema nervosum centrale" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision [Term] id: UBERON:0001021 name: nerve synonym: "nerves" EXACT [] synonym: "neural subtree" RELATED [] synonym: "peripheral nerve" EXACT [] is_a: UBERON:0000122 ! neuron projection bundle [Term] id: UBERON:0001032 name: sensory system synonym: "organa sensuum" EXACT [] synonym: "organa sensuum" RELATED [] synonym: "sense organ subsystem" EXACT [] synonym: "sense organs" EXACT [] synonym: "sense organs set" EXACT [] synonym: "sensory organ system" RELATED [] synonym: "sensory subsystem" EXACT [] synonym: "sensory systems" EXACT [] synonym: "set of sense organs" RELATED [] is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0001040 name: yolk sac synonym: "saccus vitellinus" RELATED [] synonym: "vesicula umbilicalis" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane [Term] id: UBERON:0001043 name: esophagus synonym: "gullet" EXACT [] synonym: "oesophagus" EXACT [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0001044 name: saliva-secreting gland synonym: "glandulae salivariae" RELATED [] synonym: "salivary gland" EXACT [] is_a: UBERON:0010047 ! oral gland [Term] id: UBERON:0001052 name: rectum synonym: "intestinum rectum" RELATED [] synonym: "rectal sac" RELATED [] synonym: "terminal portion of intestine" EXACT [] synonym: "terminal portion of large intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0001054 name: Malpighian tubule synonym: "Malphigian tube" RELATED [] synonym: "tuba Malpighii" RELATED [] is_a: UBERON:0009773 ! renal tubule [Term] id: UBERON:0001062 name: anatomical entity [Term] id: UBERON:0001064 name: ventral pancreatic duct synonym: "canal of Wirsung" RELATED [] synonym: "chief pancreatic duct" EXACT [] synonym: "duct of Wirsung" EXACT [] synonym: "ductus pancreatis ventralis" RELATED [] synonym: "hepaticopancreatic duct" RELATED [] synonym: "main pancreatic duct" EXACT [] synonym: "pancreatic duct" BROAD [] is_a: UBERON:0007329 ! pancreatic duct [Term] id: UBERON:0001084 name: skin of head synonym: "adult head zone of skin" EXACT [] synonym: "head skin" EXACT [] synonym: "head zone of skin" EXACT [] synonym: "zone of skin of adult head" EXACT [] synonym: "zone of skin of head" EXACT [] is_a: UBERON:0012180 ! head or neck skin [Term] id: UBERON:0001085 name: skin of trunk synonym: "torso zone of skin" EXACT [] synonym: "trunk skin" EXACT [] synonym: "trunk zone of skin" EXACT [] synonym: "zone of skin of torso" EXACT [] synonym: "zone of skin of trunk" EXACT [] is_a: UBERON:0000014 ! zone of skin [Term] id: UBERON:0001132 name: parathyroid gland synonym: "epithelial body" RELATED [] synonym: "parathyroid" EXACT [] synonym: "parathyroid secreting cell" RELATED [] is_a: UBERON:0002368 ! endocrine gland [Term] id: UBERON:0001133 name: cardiac muscle tissue synonym: "cardiac muscle" EXACT [] synonym: "cardiac muscle muscle tissue" EXACT [] synonym: "cardiac muscle textus muscularis" EXACT [] synonym: "cardiac musculature" RELATED [] synonym: "heart muscle muscle tissue" EXACT [] synonym: "heart muscle textus muscularis" EXACT [] synonym: "heart myocardium muscle tissue" EXACT [] synonym: "heart myocardium textus muscularis" EXACT [] synonym: "muscle of heart muscle tissue" EXACT [] synonym: "muscle of heart textus muscularis" EXACT [] synonym: "muscle tissue of cardiac muscle" EXACT [] synonym: "muscle tissue of heart muscle" EXACT [] synonym: "muscle tissue of heart myocardium" EXACT [] synonym: "muscle tissue of muscle of heart" EXACT [] synonym: "muscle tissue of myocardium" EXACT [] synonym: "myocardium muscle tissue" EXACT [] synonym: "myocardium textus muscularis" EXACT [] synonym: "textus muscularis of cardiac muscle" EXACT [] synonym: "textus muscularis of heart muscle" EXACT [] synonym: "textus muscularis of heart myocardium" EXACT [] synonym: "textus muscularis of muscle of heart" EXACT [] synonym: "textus muscularis of myocardium" EXACT [] is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001134 name: skeletal muscle tissue synonym: "skeletal muscle" BROAD [] synonym: "skeletal muscle system" RELATED [] synonym: "somatic muscle" RELATED [] is_a: UBERON:0002036 ! striated muscle tissue [Term] id: UBERON:0001135 name: smooth muscle tissue synonym: "involuntary muscle" EXACT [] synonym: "non-striated muscle" EXACT [] synonym: "smooth muscle" EXACT [] synonym: "textus muscularis levis; textus muscularis nonstriatus" RELATED [] synonym: "textus muscularis nonstriatus" EXACT [] synonym: "visceral muscle" NARROW [] synonym: "visceral muscle tissue" NARROW [] is_a: UBERON:0002385 ! muscle tissue [Term] id: UBERON:0001136 name: mesothelium is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0001140 name: renal vein synonym: "kidney vein" EXACT [] synonym: "renal venous tree" EXACT [] synonym: "vein of kidney" EXACT [] synonym: "venae renales" RELATED [] is_a: UBERON:0001638 ! vein [Term] id: UBERON:0001153 name: caecum synonym: "blind intestine" RELATED [] synonym: "blindgut" RELATED [] synonym: "caeca" NARROW [] synonym: "caecum" EXACT [] synonym: "ceca" NARROW [] synonym: "cecum" EXACT [] synonym: "intestinum caecum" RELATED [] synonym: "intestinum crassum caecum" EXACT [] synonym: "intestinum crassum cecum" RELATED [] is_a: UBERON:0000168 ! proximal-distal subdivision of colon is_a: UBERON:0009854 ! digestive tract diverticulum [Term] id: UBERON:0001154 name: vermiform appendix synonym: "apex of caecum" RELATED [] synonym: "apex of cecum" RELATED [] synonym: "appendix" EXACT [] synonym: "appendix vermiformis" EXACT [] synonym: "appendix vermiformis" RELATED [] synonym: "caecal appendix" EXACT [] synonym: "cecal appendix" EXACT [] synonym: "vermix" BROAD [] is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0001155 name: colon synonym: "hindgut" RELATED [] synonym: "large bowel" EXACT [] synonym: "posterior intestine" NARROW [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0001156 name: ascending colon synonym: "colon ascendens" EXACT [] synonym: "spiral colon" RELATED [] is_a: UBERON:0000168 ! proximal-distal subdivision of colon [Term] id: UBERON:0001157 name: transverse colon synonym: "colon transversum" EXACT [] is_a: UBERON:0000168 ! proximal-distal subdivision of colon [Term] id: UBERON:0001158 name: descending colon synonym: "colon descendens" EXACT [] is_a: UBERON:0000168 ! proximal-distal subdivision of colon [Term] id: UBERON:0001159 name: sigmoid colon synonym: "colon sigmoideum" RELATED [] synonym: "pelvic colon" RELATED [] synonym: "sigmoid colon" RELATED [] synonym: "sigmoid flexure" RELATED [] is_a: UBERON:0000168 ! proximal-distal subdivision of colon [Term] id: UBERON:0001160 name: fundus of stomach synonym: "fundus gastricus" RELATED [] synonym: "fundus gastricus (ventricularis)" EXACT [] synonym: "fundus gastricus ventricularis" RELATED [] synonym: "fundus ventricularis" RELATED [] synonym: "fundus ventriculi" RELATED [] synonym: "gastric fundus" EXACT [] synonym: "stomach fundus" EXACT [] is_a: UBERON:0009870 ! zone of stomach [Term] id: UBERON:0001178 name: visceral peritoneum is_a: UBERON:0000042 ! serous membrane [Term] id: UBERON:0001179 name: peritoneal cavity synonym: "cavitas peritonealis" RELATED [] synonym: "saccus serosus peritonei" RELATED [] is_a: UBERON:0002553 ! anatomical cavity [Term] id: UBERON:0001199 name: mucosa of stomach synonym: "gastric mucosa" EXACT [] synonym: "gastric mucous membrane" EXACT [] synonym: "Magenschleimhaut" RELATED [] synonym: "mucosa of organ of stomach" EXACT [] synonym: "mucosa of organ of ventriculus" EXACT [] synonym: "mucosa of ventriculus" EXACT [] synonym: "mucous membrane of stomach" EXACT [] synonym: "mucous membrane of ventriculus" EXACT [] synonym: "organ mucosa of stomach" EXACT [] synonym: "organ mucosa of ventriculus" EXACT [] synonym: "stomach mucosa" EXACT [] synonym: "stomach mucosa of organ" EXACT [] synonym: "stomach mucous membrane" EXACT [] synonym: "stomach organ mucosa" EXACT [] synonym: "tunica mucosa (gaster)" EXACT [] synonym: "tunica mucosa gastricae" EXACT [] synonym: "tunica mucosa gastris" RELATED [] synonym: "ventriculus mucosa" EXACT [] synonym: "ventriculus mucosa of organ" EXACT [] synonym: "ventriculus mucous membrane" EXACT [] synonym: "ventriculus organ mucosa" EXACT [] is_a: UBERON:0004786 ! gastrointestinal system mucosa is_a: UBERON:0009034 ! stomach region [Term] id: UBERON:0001211 name: Peyer's patch synonym: "aggregated lymphoid follicle of intestine" RELATED [] synonym: "aggregated lymphoid nodule" RELATED [] synonym: "noduli lymphoidei aggregati" EXACT [] synonym: "Peyers gland" RELATED [] synonym: "Peyers patch" RELATED [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue [Term] id: UBERON:0001212 name: duodenal gland synonym: "Brunner's gland" EXACT [] synonym: "gland of Brunner" EXACT [] synonym: "glandula duodenales" RELATED [] synonym: "glandula duodenales Brunneri" RELATED [] synonym: "submucosal gland of duodenum" EXACT [] is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0011148 ! submucosal gland [Term] id: UBERON:0001213 name: intestinal villus synonym: "enteric villi" EXACT [] synonym: "enteric villous" EXACT [] synonym: "enteric villus" EXACT [] synonym: "intestinal villi" EXACT [] synonym: "intestinal villus layer" RELATED [] synonym: "small intestine villus" RELATED [] synonym: "villi intestinales" EXACT [] synonym: "villi intestinales" RELATED [] synonym: "villus" EXACT [] synonym: "villus intestinalis (intestinum tenue)" EXACT [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0001224 name: renal pelvis synonym: "kidney pelvis" EXACT [] synonym: "p. renallis" RELATED [] synonym: "pelvis of ureter" EXACT [] synonym: "pyelum" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0001225 name: cortex of kidney synonym: "cortex renalis" EXACT [] synonym: "kidney cortex" EXACT [] synonym: "renal cortex" EXACT [] is_a: UBERON:0001851 ! cortex [Term] id: UBERON:0001229 name: renal corpuscle synonym: "corpusculum renale" EXACT [] synonym: "corpusculum renis" RELATED [] synonym: "cortical renal corpuscle" RELATED [] synonym: "kidney corpuscle" RELATED [] synonym: "malphighian corpuscle" RELATED [] synonym: "malphigian corpuscle" EXACT [] synonym: "Malpighian corpuscle" EXACT [] is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0001230 name: glomerular capsule synonym: "Bowman's capsule" EXACT [] synonym: "bowman's capsule" RELATED [] synonym: "Bowmans capsule" EXACT [] synonym: "capsula glomerularis" EXACT [] synonym: "capsula glomeruli" RELATED [] synonym: "malphigian capsule" RELATED [] synonym: "Mueller capsule" RELATED [] synonym: "Muellerian capsule" RELATED [] synonym: "pronephric glomerular capsule" RELATED [] synonym: "renal glomerular capsule" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001231 name: nephron tubule synonym: "kidney tubule" EXACT [] synonym: "renal tubule" BROAD [] synonym: "tubulus renalis" EXACT [] synonym: "uriniferous tubule" RELATED [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0009773 ! renal tubule [Term] id: UBERON:0001232 name: collecting duct of renal tubule synonym: "arcuate renal tubule" RELATED [] synonym: "collecting duct" EXACT [] synonym: "collecting duct system" RELATED [] synonym: "collecting tubule" RELATED [] synonym: "junctional tube" RELATED [] synonym: "kidney collecting duct" EXACT [] synonym: "kidney collecting tubule" RELATED [] synonym: "renal collecting tubule" EXACT [] synonym: "tubulus renalis arcuatus" EXACT [] synonym: "tubulus renalis colligens" EXACT [] synonym: "ureteric tree" RELATED [] is_a: UBERON:0006555 ! excretory tube [Term] id: UBERON:0001235 name: adrenal cortex synonym: "adrenal gland cortex" EXACT [] synonym: "cortex (glandula suprarenalis)" EXACT [] synonym: "cortex glandulae suprarenalis" RELATED [] synonym: "cortex of adrenal gland" EXACT [] synonym: "cortex of suprarenal gland" EXACT [] synonym: "suprarenal" RELATED [] synonym: "suprarenal cortex" EXACT [] is_a: UBERON:0001851 ! cortex is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0001236 name: adrenal medulla synonym: "adrenal central medulla" RELATED [] synonym: "adrenal gland medulla" EXACT [] synonym: "chromaffin cells" RELATED [] synonym: "medulla (glandula suprarenalis)" EXACT [] synonym: "medulla glandulae suprarenalis" EXACT [] synonym: "medulla of adrenal gland" EXACT [] synonym: "medulla of glandula suprarenalis" RELATED [] synonym: "medulla of suprarenal gland" EXACT [] synonym: "suprarenal medulla" EXACT [] is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0001237 name: paraaortic body synonym: "organ of Zuckerkandl" EXACT [] synonym: "para-aortic body" RELATED [] synonym: "paraganglia of zuckerkandl" RELATED [] synonym: "paraganglion of Zuckerkandl" EXACT [] is_a: UBERON:0012279 ! chromaffin paraganglion [Term] id: UBERON:0001238 name: lamina propria of small intestine synonym: "lamina propria mucosa of small bowel" EXACT [] synonym: "lamina propria mucosa of small intestine" EXACT [] synonym: "lamina propria mucosae of small bowel" EXACT [] synonym: "lamina propria mucosae of small intestine" EXACT [] synonym: "lamina propria of mucosa of small intestine" EXACT [] synonym: "lamina propria of small bowel" EXACT [] synonym: "small bowel lamina propria" EXACT [] synonym: "small bowel lamina propria mucosa" EXACT [] synonym: "small bowel lamina propria mucosae" EXACT [] synonym: "small intestine lamina propria" EXACT [] synonym: "small intestine lamina propria mucosa" EXACT [] synonym: "small intestine lamina propria mucosae" EXACT [] is_a: UBERON:0004780 ! gastrointestinal system lamina propria [Term] id: UBERON:0001242 name: intestinal mucosa synonym: "bowel mucosa" EXACT [] synonym: "bowel mucosa of organ" EXACT [] synonym: "bowel mucous membrane" EXACT [] synonym: "bowel organ mucosa" EXACT [] synonym: "intestine mucosa" EXACT [] synonym: "intestine mucosa of organ" EXACT [] synonym: "intestine mucous membrane" EXACT [] synonym: "intestine organ mucosa" EXACT [] synonym: "mucosa of bowel" EXACT [] synonym: "mucosa of intestine" EXACT [] synonym: "mucosa of organ of bowel" EXACT [] synonym: "mucosa of organ of intestine" EXACT [] synonym: "mucous membrane of bowel" EXACT [] synonym: "mucous membrane of intestine" EXACT [] synonym: "organ mucosa of bowel" EXACT [] synonym: "organ mucosa of intestine" EXACT [] synonym: "tunica mucosa intestini" EXACT [] is_a: UBERON:0004786 ! gastrointestinal system mucosa [Term] id: UBERON:0001249 name: spleen lymphoid follicle synonym: "lymphatic follicle of spleen" EXACT [] synonym: "lymphoid follicle of spleen" EXACT [] synonym: "lymphoid nodule of spleen" EXACT [] synonym: "Malpighian body" EXACT [] synonym: "spleen B cell follicle" EXACT [] synonym: "spleen lymphoid follicle" EXACT [] synonym: "spleen lymphoid nodule" RELATED [] synonym: "splenic B cell follicle" EXACT [] synonym: "splenic lymphatic follicle" EXACT [] synonym: "splenic lymphoid follicle" EXACT [] is_a: UBERON:0000444 ! lymphoid follicle is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0001250 name: red pulp of spleen synonym: "pulpa rubra" EXACT [] synonym: "pulpa splenica" RELATED [] synonym: "red pulp" EXACT [] synonym: "spleen red pulp" EXACT [] synonym: "splenic red pulp" EXACT [] is_a: UBERON:1000023 ! spleen pulp [Term] id: UBERON:0001251 name: marginal zone of spleen synonym: "junctional zone of spleen" EXACT [] synonym: "marginal zone" BROAD [] synonym: "spleen marginal zone" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0001252 name: adventitia of ureter synonym: "external adventitia of ureter" EXACT [] synonym: "ureter adventitia" EXACT [] synonym: "ureteral adventitia" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005742 ! adventitia [Term] id: UBERON:0001254 name: urothelium of ureter synonym: "transitional epithelium of ureter" EXACT [] synonym: "ureter luminal urothelium" RELATED [] synonym: "ureter transitional epithelium" EXACT [] synonym: "ureter urothelium" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000365 ! urothelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0001255 name: urinary bladder synonym: "bladder" BROAD [] synonym: "urocyst" RELATED [] synonym: "vesica" RELATED [] synonym: "vesica urinaria" EXACT [] is_a: UBERON:0002075 ! viscus is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0018707 ! bladder organ [Term] id: UBERON:0001257 name: trigone of urinary bladder synonym: "bladder trigone" EXACT [] synonym: "deep trigone" EXACT [] synonym: "dorsal bladder neck" RELATED [] synonym: "Lieutaud's trigone" EXACT [] synonym: "musculus trigoni vesicae profundus" EXACT [] synonym: "trigone of bladder" EXACT [] synonym: "trigonum vesicae" EXACT [] synonym: "trigonum vesicae urinariae" RELATED [] synonym: "urinary bladder trigone" EXACT [] synonym: "vesical trigone" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0001263 name: pancreatic acinus synonym: "acinus pancreaticus" EXACT [] synonym: "pancreas acinus" EXACT [] synonym: "pancreatic acinar" RELATED [] synonym: "pancreatic acini" RELATED [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013232 ! serous acinus [Term] id: UBERON:0001264 name: pancreas is_a: UBERON:0002075 ! viscus [Term] id: UBERON:0001266 name: splenic cord synonym: "cord of Billroth" EXACT [] synonym: "cord of Bilroth" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0001276 name: epithelium of stomach synonym: "epithelial tissue of stomach" EXACT [] synonym: "epithelial tissue of ventriculus" EXACT [] synonym: "epithelium of ventriculus" EXACT [] synonym: "gastric epithelium" RELATED [] synonym: "stomach epithelial tissue" EXACT [] synonym: "stomach epithelium" EXACT [] synonym: "ventriculus epithelial tissue" EXACT [] synonym: "ventriculus epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004808 ! gastrointestinal system epithelium is_a: UBERON:0015833 ! foregut epithelium [Term] id: UBERON:0001277 name: intestinal epithelium synonym: "bowel epithelial tissue" EXACT [] synonym: "bowel epithelium" EXACT [] synonym: "epithelial tissue of bowel" EXACT [] synonym: "epithelial tissue of intestine" EXACT [] synonym: "epithelium of bowel" EXACT [] synonym: "epithelium of intestine" EXACT [] synonym: "intestine epithelial tissue" EXACT [] synonym: "intestine epithelium" RELATED [] synonym: "villous epithelium" NARROW [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004808 ! gastrointestinal system epithelium [Term] id: UBERON:0001278 name: epithelium of large intestine synonym: "epithelial tissue of large intestine" EXACT [] synonym: "large intestinal epithelium" EXACT [] synonym: "large intestine epithelial tissue" EXACT [] synonym: "large intestine epithelium" EXACT [] is_a: UBERON:0001277 ! intestinal epithelium [Term] id: UBERON:0001281 name: hepatic sinusoid synonym: "hepatic sinusoids" RELATED [] synonym: "liver hepatic sinusoids" EXACT [] synonym: "liver sinusoid" EXACT [] synonym: "liver sinusoidal blood vessel" EXACT [] synonym: "sinusoid of liver" EXACT [] synonym: "sinusoidal blood vessel of liver" EXACT [] synonym: "vas capillare sinusoideum" EXACT [] synonym: "vas sinusoideum" EXACT [] is_a: UBERON:0003909 ! sinusoid is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015796 ! liver blood vessel [Term] id: UBERON:0001285 name: nephron synonym: "mature nephron" NARROW [] synonym: "nephroneum" RELATED [] synonym: "tubulus renalis" RELATED [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001287 name: proximal convoluted tubule synonym: "1st convoluted tubule" RELATED [] synonym: "first convoluted tubule" RELATED [] synonym: "kidney proximal convoluted tubule" RELATED [] synonym: "PCT" RELATED [] synonym: "proximal convoluted renal tubule" EXACT [] synonym: "renal proximal convoluted tubule" RELATED [] synonym: "tubulus contortus proximalis" EXACT [] synonym: "tubulus contortus proximalis" RELATED [] synonym: "tubulus convolutus proximalis" RELATED [] is_a: UBERON:0006534 ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0008404 ! proximale tubular epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0001288 name: loop of Henle synonym: "ansa nephroni" EXACT [] synonym: "Henle loop" EXACT [] synonym: "henle's loop" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0001289 name: descending limb of loop of Henle synonym: "descending limb" BROAD [] synonym: "descending limb of Henle's loop" EXACT [] synonym: "loop of Henle descending limb" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0001290 name: proximal straight tubule synonym: "pars recta" RELATED [] synonym: "pars recta tubuli renalis" RELATED [] synonym: "proximal tubule segment 3" RELATED [] synonym: "S3" EXACT [] synonym: "segment 3 of proximal tubule" RELATED [] synonym: "thick descending limb of proximal tubule" EXACT [] synonym: "tubulus rectus proximalis" EXACT [] is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0008404 ! proximale tubular epithelium is_a: UBERON:0009035 ! renal straight tubule [Term] id: UBERON:0001291 name: thick ascending limb of loop of Henle synonym: "ascending thick limb" EXACT [] synonym: "distal straight tubule" EXACT [] synonym: "loop of Henle ascending limb thick segment" EXACT [] synonym: "straight portion of distal convoluted renal tubule" EXACT [] synonym: "straight portion of distal convoluted tubule" EXACT [] synonym: "thick ascending limb" EXACT [] synonym: "thick ascending limb of distal tubule" EXACT [] synonym: "thick ascending limb of Henle's loop" EXACT [] synonym: "tubulus rectus distalis" EXACT [] synonym: "tubulus rectus distalis" RELATED [] is_a: UBERON:0008408 ! distal tubular epithelium is_a: UBERON:0009035 ! renal straight tubule [Term] id: UBERON:0001292 name: distal convoluted tubule synonym: "distal convoluted renal tubule" EXACT [] synonym: "second convoluted tubule" RELATED [] synonym: "tubulus contortus distalis" EXACT [] synonym: "tubulus contortus distalis" RELATED [] synonym: "tubulus convolutus distalis" RELATED [] is_a: UBERON:0006534 ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0008408 ! distal tubular epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0001293 name: outer medulla of kidney synonym: "kidney outer medulla" RELATED [] synonym: "outer renal medulla" EXACT [] synonym: "outer zone of medulla of kidney" EXACT [] synonym: "outer zone of renal medulla" EXACT [] synonym: "renal outer medulla" EXACT [] synonym: "set of outer region of renal pyramids" RELATED [] synonym: "zona externa (medullaris renalis)" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001294 name: inner medulla of kidney synonym: "inner renal medulla" EXACT [] synonym: "inner zone of medulla of kidney" EXACT [] synonym: "inner zone of renal medulla" EXACT [] synonym: "kidney inner medulla" RELATED [] synonym: "renal inner medulla" EXACT [] synonym: "set of inner region of renal pyramids" EXACT [] synonym: "zona interna (medullaris renalis)" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001295 name: endometrium synonym: "tunica mucosa (endometrium)" EXACT [] synonym: "tunica mucosa uteri" EXACT [] synonym: "uterine endometrium" EXACT [] synonym: "uterine mucosa" RELATED [] synonym: "uterine mucous membrane" RELATED [] is_a: UBERON:0019042 ! reproductive system mucosa [Term] id: UBERON:0001296 name: myometrium synonym: "tunica muscularis" RELATED [] synonym: "tunica muscularis (myometrium)" EXACT [] synonym: "uterine myometrium" RELATED [] synonym: "uterine smooth muscle" RELATED [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034933 ! layer of smooth muscle tissue [Term] id: UBERON:0001301 name: epididymis synonym: "epididymus" EXACT [] synonym: "Nebenhoden@ge" RELATED [] is_a: UBERON:0005904 ! duct of male reproductive system [Term] id: UBERON:0001305 name: ovarian follicle synonym: "egg follicle" RELATED [] synonym: "follicle of ovary" EXACT [] synonym: "follicle of ovary viewed macroscopically" EXACT [] synonym: "folliculi ovarici primarii" RELATED [] synonym: "folliculi ovarici vesiculosi" RELATED [] synonym: "ovary follicle" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0001310 name: umbilical artery synonym: "a. umbilicalis" RELATED [] is_a: UBERON:0001637 ! artery is_a: UBERON:0010260 ! umbilical blood vessel [Term] id: UBERON:0001331 name: skin of penis synonym: "penile skin" EXACT [] synonym: "penis skin" EXACT [] synonym: "penis zone of skin" EXACT [] synonym: "zone of skin of penis" EXACT [] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0001332 name: prepuce of penis synonym: "foreskin" RELATED [] synonym: "penile prepuce" EXACT [] synonym: "praeputium" RELATED [] synonym: "prepuce" BROAD [] synonym: "prepuce of male" EXACT [] synonym: "prepucium" RELATED [] synonym: "preputium" BROAD [] is_a: UBERON:0011374 ! prepuce [Term] id: UBERON:0001334 name: female urethra synonym: "urethra feminina" RELATED [] synonym: "urethra muliebris" RELATED [] is_a: UBERON:0000057 ! urethra [Term] id: UBERON:0001343 name: seminiferous tubule of testis synonym: "seminiferous cord" EXACT [] synonym: "seminiferous tubule" EXACT [] synonym: "testis - seminiferous tubule" EXACT [] synonym: "tubuli seminiferi" EXACT [] synonym: "tubuli seminiferi" RELATED [] is_a: UBERON:0005904 ! duct of male reproductive system [Term] id: UBERON:0001344 name: epithelium of vagina synonym: "epithelial tissue of vagina" EXACT [] synonym: "epithelium, vaginal" RELATED [] synonym: "vagina epithelial tissue" EXACT [] synonym: "vagina epithelium" EXACT [] synonym: "vaginal epithelium" EXACT [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0004804 ! oviduct epithelium [Term] id: UBERON:0001347 name: white adipose tissue synonym: "adipocytus unigutturalis" EXACT [] synonym: "textus adiposus albus" EXACT [] synonym: "textus adiposus albus" RELATED [] synonym: "unilocular adipose tissue" EXACT [] synonym: "white fat" EXACT [] is_a: UBERON:0001013 ! adipose tissue [Term] id: UBERON:0001348 name: brown adipose tissue synonym: "adipocytus multigutturalis" EXACT [] synonym: "brown fat" EXACT [] synonym: "multilocular adipose tissue" EXACT [] synonym: "textus adiposus fuscus" EXACT [] synonym: "textus adiposus fuscus" RELATED [] is_a: UBERON:0001013 ! adipose tissue [Term] id: UBERON:0001351 name: lacrimal sac synonym: "lachrymal sac" EXACT [] synonym: "lacrymal sac" EXACT [] synonym: "saccus lacrimalis" EXACT [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0001352 name: external acoustic meatus synonym: "auditory canal" EXACT [] synonym: "auditory meatus" RELATED [] synonym: "ear canal" EXACT [] synonym: "external acoustic tube" EXACT [] synonym: "external auditory canal" EXACT [] synonym: "external auditory meatus" RELATED [] synonym: "external auditory tube" EXACT [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001366 name: parietal peritoneum synonym: "peritoneal cavity lining" EXACT [] is_a: UBERON:0000042 ! serous membrane [Term] id: UBERON:0001384 name: primary motor cortex synonym: "excitable area" RELATED [] synonym: "gyrus precentralis" RELATED [] synonym: "motor area" RELATED [] synonym: "motor cortex" EXACT [] synonym: "prefrontal gyrus" RELATED [] synonym: "primary motor area" RELATED [] synonym: "Rolando's area" RELATED [] synonym: "somatic motor areas" RELATED [] synonym: "somatomotor areas" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001416 name: skin of abdomen synonym: "abdomen skin" EXACT [] synonym: "abdomen zone of skin" EXACT [] synonym: "abdominal skin" EXACT [] synonym: "skin of abdomen proper" EXACT [] synonym: "zone of skin of abdomen" EXACT [] is_a: UBERON:0003836 ! abdominal segment skin [Term] id: UBERON:0001419 name: skin of limb synonym: "limb skin" EXACT [] synonym: "limb zone of skin" EXACT [] synonym: "zone of skin of limb" EXACT [] is_a: UBERON:0000014 ! zone of skin [Term] id: UBERON:0001460 name: arm synonym: "brachium" RELATED [] synonym: "upper extremity" RELATED [] is_a: UBERON:0006058 ! multi-limb segment region is_a: UBERON:0008785 ! upper limb segment [Term] id: UBERON:0001471 name: skin of prepuce of penis synonym: "foreskin of penis" EXACT [] synonym: "penis foreskin" EXACT [] synonym: "preputial skin" EXACT [] is_a: UBERON:0001331 ! skin of penis [Term] id: UBERON:0001473 name: lymphatic vessel synonym: "lymph vessel" EXACT [] synonym: "vas lymphaticum" RELATED [] is_a: UBERON:0000055 ! vessel [Term] id: UBERON:0001474 name: bone element synonym: "bone" RELATED [] synonym: "bone element" EXACT [] synonym: "bone organ" EXACT [] is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0001485 name: knee joint synonym: "articulatio genus" RELATED [] synonym: "joint of knee" EXACT [] is_a: UBERON:0003840 ! hindlimb joint is_a: UBERON:0011139 ! synovial limb joint [Term] id: UBERON:0001511 name: skin of leg synonym: "leg skin" EXACT [] synonym: "leg zone of skin" EXACT [] synonym: "zone of skin of leg" EXACT [] is_a: UBERON:0003532 ! hindlimb skin [Term] id: UBERON:0001513 name: skin of pes synonym: "autopod of hind limb zone of skin" EXACT [] synonym: "autopod of hindlimb zone of skin" EXACT [] synonym: "autopod of inferior member zone of skin" EXACT [] synonym: "autopod of lower extremity zone of skin" EXACT [] synonym: "distal free limb segment of hind limb zone of skin" EXACT [] synonym: "distal free limb segment of hindlimb zone of skin" EXACT [] synonym: "distal free limb segment of inferior member zone of skin" EXACT [] synonym: "distal free limb segment of lower extremity zone of skin" EXACT [] synonym: "foot skin" EXACT [] synonym: "foot zone of skin" EXACT [] synonym: "hind limb autopod zone of skin" EXACT [] synonym: "hind limb distal free limb segment zone of skin" EXACT [] synonym: "hindlimb autopod zone of skin" EXACT [] synonym: "hindlimb distal free limb segment zone of skin" EXACT [] synonym: "inferior member autopod zone of skin" EXACT [] synonym: "inferior member distal free limb segment zone of skin" EXACT [] synonym: "lower extremity autopod zone of skin" EXACT [] synonym: "lower extremity distal free limb segment zone of skin" EXACT [] synonym: "skin of foot" EXACT [] synonym: "skin of hind-paw" NARROW [] synonym: "terminal segment of free lower limb zone of skin" EXACT [] synonym: "zone of skin of autopod of hind limb" EXACT [] synonym: "zone of skin of autopod of hindlimb" EXACT [] synonym: "zone of skin of autopod of inferior member" EXACT [] synonym: "zone of skin of autopod of lower extremity" EXACT [] synonym: "zone of skin of distal free limb segment of hind limb" EXACT [] synonym: "zone of skin of distal free limb segment of hindlimb" EXACT [] synonym: "zone of skin of distal free limb segment of inferior member" EXACT [] synonym: "zone of skin of distal free limb segment of lower extremity" EXACT [] synonym: "zone of skin of foot" EXACT [] synonym: "zone of skin of hind limb autopod" EXACT [] synonym: "zone of skin of hind limb distal free limb segment" EXACT [] synonym: "zone of skin of hindlimb autopod" EXACT [] synonym: "zone of skin of hindlimb distal free limb segment" EXACT [] synonym: "zone of skin of inferior member autopod" EXACT [] synonym: "zone of skin of inferior member distal free limb segment" EXACT [] synonym: "zone of skin of lower extremity autopod" EXACT [] synonym: "zone of skin of lower extremity distal free limb segment" EXACT [] synonym: "zone of skin of terminal segment of free lower limb" EXACT [] is_a: UBERON:0003532 ! hindlimb skin is_a: UBERON:0015790 ! autopod skin [Term] id: UBERON:0001515 name: thoracic aorta synonym: "aorta thoracalis" RELATED [] synonym: "pars thoracica aortae" RELATED [] synonym: "thoracic part of aorta" EXACT [] is_a: UBERON:0005800 ! section of aorta [Term] id: UBERON:0001529 name: brachiocephalic artery synonym: "brachiocephalic trunk" EXACT [] synonym: "innominate" BROAD [] synonym: "innominate artery" EXACT [] synonym: "truncus brachiocephalicus" EXACT [] synonym: "truncus brachiocephalicus" RELATED [] is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0001533 name: subclavian artery synonym: "arteria subclavia" EXACT [] synonym: "arteria subclavia" RELATED [] synonym: "arterial tree of upper limb" EXACT [] synonym: "PA" RELATED [] synonym: "pectoral artery" EXACT [] synonym: "subclavian arterial tree" EXACT [] is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0001552 name: kidney arcuate artery synonym: "arcuate artery" BROAD [] synonym: "renal arcuate artery" EXACT [] is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel [Term] id: UBERON:0001555 name: digestive tract synonym: "alimentary canal" NARROW [] synonym: "alimentary tract" NARROW [] synonym: "digestive canal" RELATED [] synonym: "digestive tube" EXACT [] synonym: "enteric tract" EXACT [] synonym: "gut" BROAD [] synonym: "gut tube" RELATED [] is_a: UBERON:0000025 ! tube [Term] id: UBERON:0001556 name: lower urinary tract is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0001557 name: upper respiratory tract is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract [Term] id: UBERON:0001558 name: lower respiratory tract is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract [Term] id: UBERON:0001560 name: neck of organ synonym: "organ neck" EXACT [] is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0001575 name: extrinsic muscle of tongue synonym: "extrinsic lingual muscle" EXACT [] synonym: "extrinsic tongue muscle" EXACT [] is_a: UBERON:0000378 ! tongue muscle [Term] id: UBERON:0001576 name: intrinsic muscle of tongue synonym: "intrinsic lingual muscle" EXACT [] synonym: "intrinsic tongue muscle" EXACT [] is_a: UBERON:0000078 ! mixed ectoderm/mesoderm/endoderm-derived structure is_a: UBERON:0000378 ! tongue muscle [Term] id: UBERON:0001606 name: muscle of iris synonym: "iris muscle" EXACT [] synonym: "iris muscle organ" EXACT [] synonym: "muscle organ of iris" EXACT [] is_a: UBERON:0011222 ! intra-ocular muscle [Term] id: UBERON:0001607 name: sphincter pupillae synonym: "circular fibers" RELATED [] synonym: "constrictor pupillae" RELATED [] synonym: "iris constrictor" RELATED [] synonym: "iris constrictor muscle" RELATED [] synonym: "iris sphincter" RELATED [] synonym: "iris sphincter muscle" EXACT [] synonym: "M. sphincter pupillae" EXACT [] synonym: "m. sphincter pupillae" RELATED [] synonym: "musculus sphincter pupillae" EXACT [] synonym: "pupillary constrictor muscle" RELATED [] synonym: "pupillary sphincter" RELATED [] synonym: "pupillary sphincter muscle" RELATED [] synonym: "sphincter muscle of pupil" EXACT [] synonym: "sphincter pupillae" RELATED [] synonym: "sphincter pupillae muscle" RELATED [] synonym: "spincter pupillae" RELATED [] is_a: UBERON:0001606 ! muscle of iris is_a: UBERON:0004234 ! iris smooth muscle is_a: UBERON:0007521 ! smooth muscle sphincter [Term] id: UBERON:0001608 name: dilatator pupillae synonym: "dilator muscle of pupil" EXACT [] synonym: "dilator of pupil" EXACT [] synonym: "dilator pupillae" EXACT [] synonym: "dilator pupillae muscle" EXACT [] synonym: "dilator pupillae muscle" RELATED [] synonym: "iris dilator" RELATED [] synonym: "iris dilator muscle" EXACT [] synonym: "musculus dilatator pupillae" EXACT [] synonym: "musculus dilatator pupillae" RELATED [] synonym: "musculus dilator pupillae" RELATED [] synonym: "pupil dilator" RELATED [] synonym: "pupil dilator muscle" RELATED [] synonym: "pupillary dilator" RELATED [] synonym: "pupillary dilator muscle" EXACT [] synonym: "pupillary muscle" RELATED [] synonym: "radial muscle" RELATED [] synonym: "radial muscle of iris" EXACT [] synonym: "radiating fibers" RELATED [] is_a: UBERON:0004234 ! iris smooth muscle [Term] id: UBERON:0001621 name: coronary artery synonym: "coronary arterial tree" EXACT [] synonym: "coronary vessel" RELATED [] is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0001630 name: muscle organ synonym: "muscle" BROAD [] is_a: UBERON:0000062 ! organ is_a: UBERON:0005090 ! muscle structure [Term] id: UBERON:0001637 name: artery synonym: "arterial subtree" EXACT [] synonym: "arterial system" RELATED [] synonym: "arterial tree organ part" EXACT [] synonym: "arterial vessel" RELATED [] synonym: "arteries" EXACT [] is_a: UBERON:0003509 ! arterial blood vessel [Term] id: UBERON:0001638 name: vein synonym: "vascular element" RELATED [] synonym: "vena" RELATED [] synonym: "venae" RELATED [] synonym: "venous subtree" BROAD [] synonym: "venous tree organ part" EXACT [] synonym: "venous vessel" BROAD [] is_a: UBERON:0003920 ! venous blood vessel [Term] id: UBERON:0001711 name: eyelid synonym: "blephara" RELATED [] synonym: "blepharon" EXACT [] synonym: "eye lid" EXACT [] synonym: "palpebra" EXACT [] synonym: "palpebrae" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001714 name: cranial ganglion synonym: "cranial ganglia" RELATED [] synonym: "cranial ganglion" EXACT [] synonym: "cranial ganglion part of peripheral nervous system" EXACT [] synonym: "cranial ganglion/nerve" EXACT [] synonym: "cranial nerve ganglion" EXACT [] synonym: "cranial neural ganglion" EXACT [] synonym: "cranial neural tree organ ganglion" EXACT [] synonym: "ganglion of cranial nerve" EXACT [] synonym: "ganglion of cranial neural tree organ" EXACT [] synonym: "head ganglion" RELATED [] synonym: "presumptive cranial ganglia" RELATED [] is_a: UBERON:0000045 ! ganglion [Term] id: UBERON:0001728 name: nasopharynx synonym: "epipharynx" RELATED [] synonym: "nasal part of pharynx" EXACT [] synonym: "Nasenrachenraum" RELATED [] synonym: "pars nasalis pharyngis" RELATED [] synonym: "rhinopharynx" EXACT [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0001744 name: lymphoid tissue synonym: "lymphatic tissue" EXACT [] synonym: "lymphocytic tissue" EXACT [] is_a: UBERON:0034769 ! lymphomyeloid tissue [Term] id: UBERON:0001745 name: secondary nodular lymphoid tissue synonym: "peripheral lymphoid tissue" EXACT [] synonym: "secondary lymphoid nodule" EXACT [] synonym: "secondary lymphoid tissue" EXACT [] is_a: UBERON:0000444 ! lymphoid follicle [Term] id: UBERON:0001747 name: parenchyma of thyroid gland synonym: "parenchyma glandulae thyroideae" RELATED [] synonym: "parenchyma of thyroid" EXACT [] synonym: "parenchyma of thyroid follicle" EXACT [] synonym: "parenchyma of thyroid gland follicle" EXACT [] synonym: "thyroid follicle parenchyma" EXACT [] synonym: "thyroid gland follicle parenchyma" EXACT [] synonym: "thyroid gland parenchyma" EXACT [] synonym: "thyroid parenchyma" EXACT [] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001751 name: dentine synonym: "dentin" EXACT [] synonym: "dentine of tooth" EXACT [] synonym: "predentin" NARROW [] is_a: UBERON:0010365 ! odontoid tissue is_a: UBERON:4000013 ! mineralized skeletal tissue [Term] id: UBERON:0001752 name: enamel synonym: "enamel of tooth" EXACT [] synonym: "enamel tissue" EXACT [] synonym: "enameloid" RELATED [] synonym: "tooth enamel" EXACT [] is_a: UBERON:0010365 ! odontoid tissue is_a: UBERON:4000013 ! mineralized skeletal tissue [Term] id: UBERON:0001753 name: cementum synonym: "bone of attachment" RELATED [] synonym: "cement" EXACT [] synonym: "cement of tooth" EXACT [] synonym: "cementum" EXACT [] synonym: "cementum of tooth" EXACT [] is_a: UBERON:0010365 ! odontoid tissue [Term] id: UBERON:0001754 name: dental pulp synonym: "dental pulp cell" RELATED [] synonym: "pulp of tooth" EXACT [] synonym: "tooth pulp" EXACT [] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011825 ! loose connective tissue [Term] id: UBERON:0001758 name: periodontium synonym: "paradentium" RELATED [] synonym: "periodontal ligament" RELATED [] synonym: "periodontal membrane" RELATED [] synonym: "tooth supporting structure" RELATED [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0001763 name: odontogenic papilla synonym: "dental papilla" RELATED [] synonym: "dentinal papilla" RELATED [] synonym: "dermal papilla" RELATED [] synonym: "odontogenic condensation" EXACT [] synonym: "papilla dentis" RELATED [] synonym: "pharyngeal tooth mesenchyme" NARROW [] synonym: "tooth mesenchyme" RELATED [] is_a: UBERON:0003856 ! odontogenic mesenchyme is_a: UBERON:0005856 ! developing mesenchymal condensation [Term] id: UBERON:0001765 name: mammary duct synonym: "ductus lactiferi" RELATED [] synonym: "galactophorous duct" RELATED [] synonym: "galactophorous tubule" RELATED [] synonym: "lactiferous duct" EXACT [] synonym: "lactiferous gland duct" EXACT [] synonym: "lactiferous tubule" RELATED [] synonym: "mammary gland duct" EXACT [] synonym: "mammilary duct" RELATED [] is_a: UBERON:0000058 ! duct is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0003914 ! epithelial tube [Term] id: UBERON:0001766 name: anterior chamber of eyeball synonym: "anterior chamber" EXACT [] synonym: "anterior chamber of eye" EXACT [] synonym: "camera anterior" EXACT [] synonym: "camera anterior bulbi" RELATED [] synonym: "camera anterior bulbi oculi" RELATED [] synonym: "camera oculi anterior" RELATED [] synonym: "eye anterior chamber" EXACT [] is_a: UBERON:0006311 ! chamber of eyeball [Term] id: UBERON:0001770 name: lacrimal canaliculus synonym: "canaliculus lacrimalis" RELATED [] is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001773 name: sclera synonym: "scleral capsule" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0001775 name: ciliary body synonym: "anterior uvea" RELATED [] synonym: "ciliary bodies" RELATED [] synonym: "corpus ciliare" RELATED [] synonym: "ocular ciliary body" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001776 name: optic choroid synonym: "chorioid" RELATED [] synonym: "choroid" EXACT [] synonym: "choroid coat" EXACT [] synonym: "choroidea" EXACT [] synonym: "choroidea" RELATED [] synonym: "eye choroid" EXACT [] synonym: "optic choroid" RELATED [] synonym: "posterior uvea" EXACT [] is_a: UBERON:0002203 ! vasculature of eye [Term] id: UBERON:0001777 name: substantia propria of cornea synonym: "corneal stroma" EXACT [] synonym: "stroma of cornea" EXACT [] synonym: "substantia propria" BROAD [] is_a: UBERON:0003891 ! stroma is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0001780 name: spinal nerve synonym: "backbone nerve" EXACT [] synonym: "nerve of backbone" EXACT [] synonym: "nerve of spinal column" EXACT [] synonym: "nerve of spine" EXACT [] synonym: "nerve of vertebral column" EXACT [] synonym: "nervi spinales" RELATED [] synonym: "spinal column nerve" EXACT [] synonym: "spinal nerve tree" EXACT [] synonym: "spinal nerves" RELATED [] synonym: "spine nerve" EXACT [] synonym: "vertebral column nerve" EXACT [] is_a: UBERON:0001021 ! nerve [Term] id: UBERON:0001781 name: layer of retina synonym: "retina layer" EXACT [] synonym: "retina neuronal layer" EXACT [] synonym: "retinal layer" EXACT [] synonym: "retinal neuronal layer" EXACT [] is_a: UBERON:0022303 ! nervous system cell part layer [Term] id: UBERON:0001782 name: pigmented layer of retina synonym: "epithelium, retinal pigment" RELATED [] synonym: "outer pigmented layer of retina" EXACT [] synonym: "p. pigmentosa retinae" RELATED [] synonym: "pigment epithelium of retina" EXACT [] synonym: "pigmented epithelium" RELATED [] synonym: "pigmented retina" RELATED [] synonym: "pigmented retina epithelium" EXACT [] synonym: "pigmented retinal epithelium" EXACT [] synonym: "PRE" RELATED [] synonym: "retinal pigment epithelium" EXACT [] synonym: "retinal pigment layer" RELATED [] synonym: "retinal pigmented epithelium" EXACT [] synonym: "RPE" RELATED [] synonym: "stratum pigmentosa retinae" RELATED [] synonym: "stratum pigmentosum (retina)" EXACT [] is_a: UBERON:0000957 ! lamina is_a: UBERON:0001781 ! layer of retina is_a: UBERON:0015808 ! eye epithelium [Term] id: UBERON:0001785 name: cranial nerve synonym: "cranial nerves" RELATED [] synonym: "cranial neural tree organ" EXACT [] synonym: "nervus cranialis" RELATED [] is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0034713 ! cranial neuron projection bundle [Term] id: UBERON:0001791 name: inner nuclear layer of retina synonym: "INL" NARROW [] synonym: "inner nuclear layer" EXACT [] synonym: "intermediate cell layer" EXACT [] synonym: "layer of inner granules" RELATED [] synonym: "neural retina inner nuclear layer" EXACT [] synonym: "retina inner nuclear layer" EXACT [] synonym: "retina, inner nuclear layer" RELATED [] synonym: "retinal inner nuclear layer" EXACT [] synonym: "stratum nucleare internum" EXACT [] is_a: UBERON:0001781 ! layer of retina [Term] id: UBERON:0001800 name: sensory ganglion synonym: "ganglion sensorium" EXACT [] is_a: UBERON:0000045 ! ganglion [Term] id: UBERON:0001803 name: epithelium of lens synonym: "epithelial tissue of eye lens" EXACT [] synonym: "epithelial tissue of lens" EXACT [] synonym: "epithelium lentis" EXACT [] synonym: "epithelium of eye lens" EXACT [] synonym: "eye lens epithelial tissue" EXACT [] synonym: "eye lens epithelium" EXACT [] synonym: "lens epithelial tissue" EXACT [] synonym: "lens epithelium" EXACT [] is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0015808 ! eye epithelium [Term] id: UBERON:0001811 name: conjunctiva synonym: "conjunctivae" EXACT [] synonym: "conjunctivas" EXACT [] synonym: "wall of conjunctival sac" EXACT [] is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001820 name: sweat gland synonym: "glandula sudorifera" RELATED [] synonym: "sudoriferous gland" RELATED [] synonym: "sudoriparous gland" RELATED [] is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0019319 ! exocrine gland of integumental system [Term] id: UBERON:0001821 name: sebaceous gland synonym: "glandula sebacea" RELATED [] synonym: "glandula sebaceae" RELATED [] synonym: "sebaceous follicle" RELATED [] is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0012344 ! holocrine gland is_a: UBERON:0019319 ! exocrine gland of integumental system [Term] id: UBERON:0001826 name: nasal cavity mucosa synonym: "mucosa of nose" EXACT [] synonym: "mucous membrane of nose" EXACT [] synonym: "nasal mucosa" RELATED [] synonym: "tunica mucosa nasalis" EXACT [] synonym: "tunica mucosa nasi" EXACT [] is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001828 name: gingiva synonym: "gingival mucosa" RELATED [] synonym: "gum" EXACT [] synonym: "gum tissue" EXACT [] synonym: "gums" EXACT [] is_a: UBERON:0003729 ! mouth mucosa [Term] id: UBERON:0001844 name: cochlea synonym: "cochleae" RELATED [] synonym: "cochlear duct" RELATED [] synonym: "cochlear organ" RELATED [] synonym: "cochlear part of bony labyrinth" EXACT [] synonym: "lagena" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0034921 ! multi organ part structure [Term] id: UBERON:0001850 name: lacrimal drainage system synonym: "tear duct" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0001851 name: cortex synonym: "cortex" EXACT [] synonym: "cortex of organ" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0001862 name: vestibular labyrinth synonym: "inner ear vestibular component" EXACT [] synonym: "labyrinthus vestibularis" RELATED [] synonym: "vestibular apparatus" RELATED [] synonym: "vestibular component" BROAD [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001885 name: dentate gyrus of hippocampal formation synonym: "area dentata" EXACT [] synonym: "dentate area" RELATED [] synonym: "dentate area (dentate gyrus)" EXACT [] synonym: "dentate gyrus" EXACT [] synonym: "fascia dentata" NARROW [] synonym: "gyrus dentatus" RELATED [] synonym: "hippocampal dentate gyrus" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001886 name: choroid plexus synonym: "chorioid plexus" EXACT [] synonym: "choroid plexus of cerebral hemisphere" RELATED [] synonym: "CP" BROAD [] synonym: "plexus choroideus" EXACT [] synonym: "plexus choroideus" RELATED [] synonym: "ventricular choroid plexus" RELATED [] is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005629 ! vascular plexus is_a: UBERON:0006876 ! vasculature of organ [Term] id: UBERON:0001890 name: forebrain synonym: "FB" BROAD [] synonym: "prosencephalon" RELATED [] is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0001898 name: hypothalamus synonym: "Hy" BROAD [] synonym: "hypothalamus" RELATED [] synonym: "preoptico-hypothalamic area" EXACT [] synonym: "preoptico-hypothalamic region" EXACT [] is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0001901 name: epithelium of trachea synonym: "epithelial tissue of trachea" EXACT [] synonym: "epithelial tissue of windpipe" EXACT [] synonym: "epithelium of windpipe" EXACT [] synonym: "trachea epithelial tissue" EXACT [] synonym: "trachea epithelium" EXACT [] synonym: "tracheal epithelium" EXACT [] synonym: "windpipe epithelial tissue" EXACT [] synonym: "windpipe epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0004815 ! lower respiratory tract epithelium [Term] id: UBERON:0001902 name: epithelium of small intestine synonym: "epithelial tissue of small bowel" EXACT [] synonym: "epithelial tissue of small intestine" EXACT [] synonym: "epithelium of small bowel" EXACT [] synonym: "mid intestine epithelium" EXACT [] synonym: "small bowel epithelial tissue" EXACT [] synonym: "small bowel epithelium" EXACT [] synonym: "small intestinal epithelium" EXACT [] synonym: "small intestine epithelial tissue" EXACT [] synonym: "small intestine epithelium" EXACT [] is_a: UBERON:0001277 ! intestinal epithelium [Term] id: UBERON:0001905 name: pineal body synonym: "conarium" RELATED [] synonym: "corpus pineale" EXACT [] synonym: "epiphysis" RELATED [] synonym: "epiphysis cerebri" RELATED [] synonym: "frontal organ" RELATED [] synonym: "glandula pinealis" EXACT [] synonym: "Pi" BROAD [] synonym: "pineal" RELATED [] synonym: "pineal gland" EXACT [] synonym: "pineal gland (Galen)" RELATED [] synonym: "pineal organ" EXACT [] synonym: "stirnorgan" RELATED [] is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010134 ! secretory circumventricular organ [Term] id: UBERON:0001911 name: mammary gland synonym: "Brustdruese" RELATED [] synonym: "dug" RELATED [] synonym: "glandula mammaria" EXACT [] synonym: "glandula mammaria" RELATED [] synonym: "lactiferous gland" EXACT [] synonym: "lobe of breast" NARROW [] synonym: "lobe of mammary gland" RELATED [] synonym: "mamma" RELATED [] synonym: "mammae" RELATED [] synonym: "milk patch" NARROW [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0019319 ! exocrine gland of integumental system [Term] id: UBERON:0001912 name: lobule of mammary gland synonym: "acinus of mammary gland" EXACT [] synonym: "lactiferous acinus" EXACT [] synonym: "lactiferous gland lobule" EXACT [] synonym: "lactiferous lobule" EXACT [] synonym: "lobule of lactiferous gland" EXACT [] synonym: "lobule of mammary gland" EXACT [] synonym: "mammary acinus" EXACT [] synonym: "mammary gland lobule" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0009911 ! lobule [Term] id: UBERON:0001915 name: endothelium of capillary synonym: "blood capillary endothelium" EXACT [] synonym: "capillary endothelium" EXACT [] synonym: "capillary vessel endothelium" EXACT [] synonym: "endothelium of blood capillary" EXACT [] synonym: "endothelium of capillary vessel" EXACT [] is_a: UBERON:0004638 ! blood vessel endothelium [Term] id: UBERON:0001917 name: endothelium of artery synonym: "arterial endothelium" EXACT [] synonym: "artery endothelium" EXACT [] is_a: UBERON:0003915 ! endothelial tube is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium [Term] id: UBERON:0001930 name: paraventricular nucleus of hypothalamus synonym: "filiform nucleus" EXACT [] synonym: "nuclei paraventriculares" RELATED [] synonym: "nuclei paraventricularis hypothalami" RELATED [] synonym: "nucleus filiformis" RELATED [] synonym: "nucleus hypothalami filiformis" RELATED [] synonym: "nucleus hypothalami paraventricularis" RELATED [] synonym: "nucleus paraventricularis hypothalami" RELATED [] synonym: "Pa" BROAD [] synonym: "paraventricular hypothalamic nucleus" EXACT [] synonym: "paraventricular nucleus" EXACT [] synonym: "paraventricular nucleus hypothalamus (Malone)" RELATED [] synonym: "paraventricular nucleus of the hypothalamus" RELATED [] synonym: "parvocellular hypothalamic nucleus" RELATED [] synonym: "subcommissural nucleus (Ziehen)" RELATED [] is_a: UBERON:0006568 ! hypothalamic nucleus [Term] id: UBERON:0001949 name: gingival epithelium synonym: "epithelial tissue of gingiva" EXACT [] synonym: "epithelium of gingiva" EXACT [] synonym: "gingiva epithelial tissue" EXACT [] synonym: "gingiva epithelium" EXACT [] is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0006915 ! stratified squamous epithelium is_a: UBERON:0035037 ! jaw epithelium [Term] id: UBERON:0001950 name: neocortex synonym: "cerebral neocortex" EXACT [] synonym: "homogenetic cortex" EXACT [] synonym: "homotypical cortex" EXACT [] synonym: "iso-cortex" RELATED [] synonym: "isocortex" NARROW [] synonym: "isocortex (sensu lato)" EXACT [] synonym: "neocortex (isocortex)" EXACT [] synonym: "neopallial cortex" EXACT [] synonym: "neopallium" EXACT [] synonym: "nonolfactory cortex" RELATED [] synonym: "nucleus hypoglossalis" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001951 name: epithelium of nasopharynx synonym: "epithelial tissue of nasal part of pharynx" EXACT [] synonym: "epithelial tissue of nasopharynx" EXACT [] synonym: "epithelial tissue of rhinopharynx" EXACT [] synonym: "epithelium of nasal part of pharynx" EXACT [] synonym: "epithelium of rhinopharynx" EXACT [] synonym: "nasal part of pharynx epithelial tissue" EXACT [] synonym: "nasal part of pharynx epithelium" EXACT [] synonym: "nasopharyngeal epithelium" RELATED [] synonym: "nasopharynx epithelial tissue" EXACT [] synonym: "nasopharynx epithelium" EXACT [] synonym: "rhinopharynx epithelial tissue" EXACT [] synonym: "rhinopharynx epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003351 ! pharyngeal epithelium is_a: UBERON:0004814 ! upper respiratory tract epithelium [Term] id: UBERON:0001954 name: Ammon's horn synonym: "ammon gyrus" EXACT [] synonym: "ammon horn" EXACT [] synonym: "Ammon horn fields" RELATED [] synonym: "Ammon's horn" EXACT [] synonym: "Ammons horn" RELATED [] synonym: "cornu ammonis" RELATED [] synonym: "hippocampus" RELATED [] synonym: "hippocampus major" EXACT [] synonym: "hippocampus proper" EXACT [] synonym: "hippocampus proprius" EXACT [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0001955 name: epithelium of respiratory bronchiole synonym: "bronchiolus respiratorius epithelial tissue" EXACT [] synonym: "bronchiolus respiratorius epithelium" EXACT [] synonym: "epithelial tissue of bronchiolus respiratorius" EXACT [] synonym: "epithelial tissue of respiratory bronchiole" EXACT [] synonym: "epithelium of bronchiolus respiratorius" EXACT [] synonym: "respiratory bronchiole epithelial tissue" EXACT [] synonym: "respiratory bronchiole epithelium" EXACT [] is_a: UBERON:0002051 ! epithelium of bronchiole [Term] id: UBERON:0001958 name: terminal bronchiole epithelium synonym: "bronchiolus terminalis epithelial tissue" EXACT [] synonym: "bronchiolus terminalis epithelium" EXACT [] synonym: "epithelial tissue of bronchiolus terminalis" EXACT [] synonym: "epithelial tissue of terminal bronchiole" EXACT [] synonym: "epithelium of bronchiolus terminalis" EXACT [] synonym: "epithelium of terminal bronchiole" EXACT [] synonym: "terminal bronchiole epithelial tissue" EXACT [] synonym: "terminal bronchiole epithelium" EXACT [] is_a: UBERON:0002051 ! epithelium of bronchiole [Term] id: UBERON:0001959 name: white pulp of spleen synonym: "noduli lymphoidei splenici" RELATED [] synonym: "pulpa alba" EXACT [] synonym: "spleen white pulp" EXACT [] synonym: "splenic white pulp" EXACT [] synonym: "white pulp" EXACT [] is_a: UBERON:1000023 ! spleen pulp [Term] id: UBERON:0001961 name: mucosa-associated lymphoid tissue synonym: "epithelio-lymphoid tissue" EXACT [] synonym: "MALT" EXACT [] synonym: "mucosa associated lymphatic tissue" EXACT [] synonym: "mucosa associated lymphoid tissue" EXACT [] synonym: "mucosa-associated lymphoid tissue" EXACT [] synonym: "mucosal-associated lymphatic tissue" EXACT [] synonym: "mucosal-associated lymphoid tissue" EXACT [] is_a: UBERON:0012069 ! epithelium-associated lymphoid tissue [Term] id: UBERON:0001962 name: gut-associated lymphoid tissue synonym: "GALT" RELATED [] synonym: "gut associated lymphoid tissue" EXACT [] is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: UBERON:0001963 name: bronchial-associated lymphoid tissue synonym: "BALT" RELATED [] synonym: "bronchus associated lymphoid tissue" EXACT [] is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0001976 name: epithelium of esophagus synonym: "epithelial tissue of esophagus" EXACT [] synonym: "epithelial tissue of gullet" EXACT [] synonym: "epithelial tissue of oesophagus" EXACT [] synonym: "epithelium of gullet" EXACT [] synonym: "epithelium of oesophagus" EXACT [] synonym: "esophageal epithelium" EXACT [] synonym: "esophagus epithelial tissue" EXACT [] synonym: "esophagus epithelium" EXACT [] synonym: "gullet epithelial tissue" EXACT [] synonym: "gullet epithelium" EXACT [] synonym: "oesophagus epithelial tissue" EXACT [] synonym: "oesophagus epithelium" RELATED [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium [Term] id: UBERON:0001979 name: venule synonym: "venula" RELATED [] is_a: UBERON:0003920 ! venous blood vessel [Term] id: UBERON:0001980 name: arteriole synonym: "arteriola" RELATED [] is_a: UBERON:0003509 ! arterial blood vessel [Term] id: UBERON:0001981 name: blood vessel synonym: "region of vascular tree organ" EXACT [] synonym: "vas sanguineum" RELATED [] synonym: "vascular element" BROAD [] synonym: "vascular tree organ region" EXACT [] is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0001982 name: capillary synonym: "blood capillary" EXACT [] synonym: "capillary vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0010523 ! microcirculatory vessel [Term] id: UBERON:0001983 name: crypt of Lieberkuhn synonym: "crypt of lieberkuhn" EXACT [] synonym: "crypt of Lieberkühn" EXACT [] synonym: "crypts of Lieberkühn" EXACT [] synonym: "follicles of lieberkuhn" EXACT [] synonym: "intestinal crypt" EXACT [] synonym: "intestinal crypts" EXACT [] synonym: "intestinal gland" BROAD [] synonym: "Lieberkuhn crypt" EXACT [] synonym: "lieberkuhn crypt" EXACT [] synonym: "Lieberkuhn gland" EXACT [] synonym: "Lieberkuhn's gland" EXACT [] synonym: "Lieberkuhn's glands" EXACT [] is_a: UBERON:0000333 ! intestinal gland [Term] id: UBERON:0001986 name: endothelium is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0001987 name: placenta synonym: "allantoic placenta" EXACT [] synonym: "eutherian placenta" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0001992 name: papillary layer of dermis synonym: "corpus papillary" EXACT [] synonym: "dermal papillary layer" RELATED [] synonym: "dermis papillary layer" EXACT [] synonym: "papillary dermis" EXACT [] synonym: "papillary layer" EXACT [] synonym: "papillary layer of dermis" EXACT [] synonym: "stratum papillare" EXACT [] synonym: "stratum papillare" RELATED [] synonym: "stratum papillare corii" EXACT [] synonym: "superficial dermis" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0001994 name: hyaline cartilage tissue synonym: "chondroid cartilage" RELATED [] synonym: "hyaline cartilage" EXACT [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0001995 name: fibrocartilage synonym: "fibrocartilage tissue" EXACT [] synonym: "stratified cartilage tissue" EXACT [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0001997 name: olfactory epithelium synonym: "main olfactory epithelium" EXACT [] synonym: "MOE" RELATED [] synonym: "nasal cavity olfactory epithelium" EXACT [] synonym: "nasal epithelium" RELATED [] synonym: "nasal sensory epithelium" RELATED [] synonym: "olfactory membrane" EXACT [] synonym: "olfactory sensory epithelium" EXACT [] synonym: "pseudostratified main olfactory epithelium" RELATED [] synonym: "sensory olfactory epithelium" EXACT [] is_a: UBERON:0005384 ! nasal cavity epithelium is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium [Term] id: UBERON:0002005 name: enteric nervous system synonym: "enteric PNS" EXACT [] synonym: "PNS - enteric" EXACT [] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011216 ! organ system subdivision [Term] id: UBERON:0002006 name: cortex of lymph node synonym: "cortex nodi lymphoidei" RELATED [] synonym: "lymph node cortex" EXACT [] is_a: UBERON:0001851 ! cortex [Term] id: UBERON:0002012 name: pulmonary artery synonym: "arteria pulmonalis" RELATED [] synonym: "pulmonary arterial tree" EXACT [] synonym: "pulmonary arterial tree organ part" EXACT [] synonym: "truncus pulmonalis" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001637 ! artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013768 ! great vessel of heart [Term] id: UBERON:0002018 name: synovial membrane of synovial joint synonym: "membrana synovialis capsulae articularis" EXACT [] synonym: "stratum synoviale" EXACT [] synonym: "synovial layer" BROAD [] synonym: "synovial layer of articular capsule of synovial joint" RELATED [] synonym: "synovial membrane" BROAD [] synonym: "synovial membrane of articular capsule of synovial joint" RELATED [] synonym: "synovium" BROAD [] synonym: "synovium of articular capsule of synovial joint" RELATED [] is_a: UBERON:0006915 ! stratified squamous epithelium is_a: UBERON:0007616 ! layer of synovial tissue is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0002020 name: gray matter synonym: "gray mater" RELATED [] synonym: "gray matter" EXACT [] synonym: "gray matter of neuraxis" EXACT [] synonym: "grey matter" EXACT [] synonym: "grey matter of neuraxis" EXACT [] synonym: "grey substance" EXACT [] synonym: "grisea" RELATED [] synonym: "neuronal grey matter" EXACT [] synonym: "substantia grisea" EXACT [] is_a: UBERON:0011215 ! central nervous system cell part cluster [Term] id: UBERON:0002025 name: stratum basale of epidermis synonym: "basal cell layer of epidermis" EXACT [] synonym: "basal cell layer of skin" RELATED [] synonym: "basal layer of epidermis" RELATED [] synonym: "epidermal basal stratum" EXACT [] synonym: "epidermis basal layer" RELATED [] synonym: "epidermis sensorial layer" RELATED [] synonym: "epidermis stratum basale" EXACT [] synonym: "epidermis stratum germinativum" RELATED [] synonym: "Malpighian layer" RELATED [] synonym: "rete Malphighii" EXACT [] synonym: "stratum basale" BROAD [] synonym: "stratum basalis of epidermis" EXACT [] synonym: "stratum germinativum" EXACT [] synonym: "stratum germinosum" BROAD [] synonym: "stratum germinosum of epidermis" EXACT [] synonym: "stratum Malphighi" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0002026 name: stratum spinosum of epidermis synonym: "epidermis prickle cell layer" RELATED [] synonym: "epidermis stratum spinosum" EXACT [] synonym: "prickle cell layer" RELATED [] synonym: "prickle cell layer of epidermis" EXACT [] synonym: "squamous cell layer of epidermis" EXACT [] synonym: "stratum malphighii" EXACT [] synonym: "stratum spinosum" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0002027 name: stratum corneum of epidermis synonym: "cornified layer" EXACT [] synonym: "epidermis stratum corneum" EXACT [] synonym: "horny layer" BROAD [] synonym: "horny layer of epidermis" EXACT [] synonym: "keratinized squame layer" BROAD [] synonym: "keratinized squame layer of epidermis" EXACT [] synonym: "stratum corneum" BROAD [] synonym: "stratum corneum epidermidis" RELATED [] is_a: UBERON:0003055 ! periderm is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0002029 name: epithelium of gall bladder synonym: "biliary epithelium" RELATED [] synonym: "epithelial tissue of gall bladder" EXACT [] synonym: "epithelial tissue of gallbladder" EXACT [] synonym: "epithelium of gallbladder" EXACT [] synonym: "gall bladder epithelial tissue" EXACT [] synonym: "gall bladder epithelium" EXACT [] synonym: "gallbladder epithelial tissue" EXACT [] synonym: "gallbladder epithelium" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005911 ! endo-epithelium [Term] id: UBERON:0002031 name: epithelium of bronchus synonym: "bronchi epithelial tissue" EXACT [] synonym: "bronchi epithelium" EXACT [] synonym: "bronchial epithelium" EXACT [] synonym: "bronchial trunk epithelial tissue" EXACT [] synonym: "bronchial trunk epithelium" EXACT [] synonym: "bronchus epithelial tissue" EXACT [] synonym: "bronchus epithelium" EXACT [] synonym: "epithelial tissue of bronchi" EXACT [] synonym: "epithelial tissue of bronchial trunk" EXACT [] synonym: "epithelial tissue of bronchus" EXACT [] synonym: "epithelium of bronchi" EXACT [] synonym: "epithelium of bronchial trunk" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0004815 ! lower respiratory tract epithelium [Term] id: UBERON:0002036 name: striated muscle tissue synonym: "striated muscle" EXACT [] is_a: UBERON:0002385 ! muscle tissue [Term] id: UBERON:0002037 name: cerebellum synonym: "corpus cerebelli" RELATED [] synonym: "epencephalon-1" EXACT [] synonym: "infratentorial region" BROAD [] synonym: "parencephalon" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002038 name: substantia nigra synonym: "nucleus of basis pedunculi" EXACT [] synonym: "nucleus pigmentosus subthalamo-peduncularis" RELATED [] synonym: "SN" BROAD [] synonym: "Soemmering's substance" EXACT [] synonym: "substancia nigra" RELATED [] synonym: "substantia nigra (Soemmerringi)" RELATED [] is_a: UBERON:0009661 ! midbrain nucleus [Term] id: UBERON:0002046 name: thyroid gland synonym: "glandula thyroidea" RELATED [] synonym: "thyroid" EXACT [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002048 name: lung synonym: "pulmo" EXACT [] is_a: UBERON:0000171 ! respiration organ is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0002049 name: vasculature synonym: "vascular network" EXACT [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0002050 name: embryonic structure synonym: "developing embryonic structure" EXACT [] synonym: "developing structure" RELATED [] synonym: "embryonale Struktur" RELATED [] synonym: "embryonic anatomical structure" EXACT [] is_a: UBERON:0000061 ! anatomical structure is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0002051 name: epithelium of bronchiole synonym: "bronchiolar epithelium" EXACT [] synonym: "bronchiole epithelial tissue" EXACT [] synonym: "bronchiole epithelium" EXACT [] synonym: "epithelial tissue of bronchiole" EXACT [] synonym: "epithelial tissue of lobular bronchiole" EXACT [] synonym: "epithelium of lobular bronchiole" EXACT [] synonym: "lobular bronchiole epithelial tissue" EXACT [] synonym: "lobular bronchiole epithelium" EXACT [] is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus is_a: UBERON:0003350 ! epithelium of mucosa [Term] id: UBERON:0002053 name: zona glomerulosa of adrenal gland synonym: "adrenal gland zona glomerulosa" EXACT [] synonym: "glomerulosa" RELATED [] synonym: "zona glomerulosa" EXACT [] synonym: "zona glomerulosa of suprarenal gland" EXACT [] is_a: UBERON:0009753 ! adrenal gland cortex zone [Term] id: UBERON:0002062 name: endocardial cushion synonym: "atrioventricular cushion" EXACT [] synonym: "AV cushion" EXACT [] synonym: "cardiac cushion" EXACT [] synonym: "endocardial cushion tissue" EXACT [] synonym: "endocardial cushions" RELATED [] is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0009751 ! cardiac mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest [Term] id: UBERON:0002066 name: umbilical vein synonym: "vena umbilicalis" RELATED [] is_a: UBERON:0001638 ! vein is_a: UBERON:0010260 ! umbilical blood vessel [Term] id: UBERON:0002067 name: dermis synonym: "corium" RELATED [] synonym: "cutis" RELATED [] synonym: "vertebrate dermis" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0002069 name: stratum granulosum of epidermis synonym: "epidermis granular layer" RELATED [] synonym: "epidermis stratum granulosum" EXACT [] synonym: "granular layer of epidermis" EXACT [] synonym: "stratum granulosum" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0002072 name: hypodermis synonym: "hypoderm" EXACT [] synonym: "sub-tegumental tissue" RELATED [] synonym: "subcutaneous tissue" RELATED [] synonym: "subcutis" RELATED [] synonym: "subtegumental tissue" RELATED [] synonym: "superficial fascia" RELATED [] synonym: "tela subcutanea" RELATED [] synonym: "vertebrate hypodermis" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer [Term] id: UBERON:0002073 name: hair follicle synonym: "folliculus pili" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002075 name: viscus synonym: "Organsystem@ge" RELATED [] synonym: "splanchnic tissue" RELATED [] synonym: "viscera" RELATED [] synonym: "visceral organ" EXACT [] synonym: "visceral organ system" EXACT [] synonym: "visceral tissue" RELATED [] is_a: UBERON:0005177 ! trunk region element [Term] id: UBERON:0002080 name: heart right ventricle synonym: "cardiac right ventricle" EXACT [] synonym: "right cardiac ventricle" RELATED [] synonym: "right ventricle" EXACT [] synonym: "right ventricle of heart" EXACT [] synonym: "ventriculus dexter" RELATED [] is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035554 ! right cardiac chamber [Term] id: UBERON:0002081 name: cardiac atrium synonym: "atria" EXACT [] synonym: "atrial tissue" RELATED [] synonym: "atrium" EXACT [] synonym: "atrium of heart" EXACT [] synonym: "Cardiac atria" EXACT [] synonym: "cardiac atria" EXACT [] synonym: "heart atrium" EXACT [] is_a: UBERON:0004151 ! cardiac chamber [Term] id: UBERON:0002082 name: cardiac ventricle synonym: "heart ventricle" EXACT [] synonym: "lower chamber of heart" EXACT [] synonym: "ventricle" BROAD [] synonym: "ventricle of heart" EXACT [] is_a: UBERON:0004151 ! cardiac chamber [Term] id: UBERON:0002084 name: heart left ventricle synonym: "cardiac left ventricle" EXACT [] synonym: "left cardiac ventricle" EXACT [] synonym: "left ventricle" EXACT [] synonym: "left ventricle of heart" EXACT [] synonym: "ventriculus sinister cordis" RELATED [] is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035553 ! left cardiac chamber [Term] id: UBERON:0002085 name: interatrial septum synonym: "atrial septum" EXACT [] synonym: "atrium septum" EXACT [] synonym: "interatrial septal wall" EXACT [] is_a: UBERON:0002099 ! cardiac septum [Term] id: UBERON:0002094 name: interventricular septum synonym: "heart interventricular septum" EXACT [] synonym: "heart ventricular septum" EXACT [] synonym: "interventricular septum of heart" RELATED [] synonym: "interventriculare cordis" RELATED [] synonym: "intraventricular septum" RELATED [] synonym: "s. interventriculare cordis" RELATED [] synonym: "septum inferius" RELATED [] synonym: "septum membranaceum" RELATED [] synonym: "ventricle septum" RELATED [] synonym: "ventricular septum" RELATED [] is_a: UBERON:0002099 ! cardiac septum [Term] id: UBERON:0002095 name: mesentery synonym: "generic mesentery" EXACT [] synonym: "mesentery (generic)" EXACT [] is_a: UBERON:0000042 ! serous membrane [Term] id: UBERON:0002097 name: skin of body synonym: "entire integument" RELATED [] synonym: "entire skin" EXACT [] synonym: "integument" RELATED [] synonym: "integumental organ" RELATED [] synonym: "pelt" RELATED [] synonym: "skin" RELATED [] synonym: "skin organ" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0002099 name: cardiac septum synonym: "cardiac septa" EXACT [] synonym: "heart septa" EXACT [] synonym: "heart septum" EXACT [] synonym: "septum of heart" EXACT [] synonym: "spiral septa" RELATED [] is_a: UBERON:0003037 ! septum is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002101 name: limb synonym: "extremities" RELATED [] synonym: "extremity" RELATED [] synonym: "flipper" NARROW [] synonym: "free limb" EXACT [] synonym: "limb sensu vertebrata" EXACT [] synonym: "pentadactyl limb" EXACT [] synonym: "tetrapod limb" EXACT [] is_a: UBERON:0004708 ! paired limb/fin [Term] id: UBERON:0002106 name: spleen synonym: "lien" RELATED [] is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0017672 ! abdominal viscera [Term] id: UBERON:0002107 name: liver synonym: "iecur" RELATED [] synonym: "jecur" RELATED [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006925 ! digestive gland [Term] id: UBERON:0002108 name: small intestine synonym: "anterior intestine" RELATED [] synonym: "intestinum tenue" RELATED [] synonym: "mid intestine" RELATED [] synonym: "small bowel" EXACT [] synonym: "small intestine" EXACT [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0002110 name: gall bladder synonym: "gall bladder" EXACT [] synonym: "gallbladder" EXACT [] synonym: "vesica biliaris" RELATED [] synonym: "vesica fellea" RELATED [] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0017672 ! abdominal viscera is_a: UBERON:0018707 ! bladder organ [Term] id: UBERON:0002113 name: kidney synonym: "reniculate kidney" NARROW [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0002114 name: duodenum synonym: "proximal intestine" RELATED [] synonym: "upper intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0002115 name: jejunum synonym: "intestinum jejunum" RELATED [] synonym: "mid-intestine" RELATED [] synonym: "middle intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0002116 name: ileum synonym: "distal intestine" RELATED [] synonym: "intestinum ileum" RELATED [] synonym: "lower intestine" RELATED [] synonym: "posterior intestine" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0002118 name: right ovary is_a: UBERON:0000992 ! female gonad is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0002119 name: left ovary is_a: UBERON:0000992 ! female gonad is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0002123 name: cortex of thymus synonym: "thymic cortex" EXACT [] synonym: "thymus cortex" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001851 ! cortex [Term] id: UBERON:0002124 name: medulla of thymus synonym: "medulla of thymus gland" EXACT [] synonym: "thymus gland medulla" EXACT [] synonym: "thymus medulla" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000958 ! medulla of organ [Term] id: UBERON:0002129 name: cerebellar cortex synonym: "cortex cerebellaris" RELATED [] synonym: "cortex cerebelli" RELATED [] synonym: "cortex of cerebellar hemisphere" EXACT [] is_a: UBERON:0019263 ! gray matter of hindbrain [Term] id: UBERON:0002165 name: endocardium synonym: "endocardial lining" EXACT [] synonym: "endocardial tissue" EXACT [] synonym: "heart endocardial tissue" RELATED [] synonym: "heart endocardium" EXACT [] is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0005983 ! heart layer is_a: UBERON:0008307 ! heart endothelium [Term] id: UBERON:0002185 name: bronchus synonym: "bronchi" EXACT [] synonym: "bronchial tissue" RELATED [] synonym: "bronchial trunk" EXACT [] is_a: UBERON:0000117 ! respiratory tube [Term] id: UBERON:0002190 name: subcutaneous adipose tissue synonym: "fatty layer of subcutaneous tissue" EXACT [] synonym: "hypodermis fat layer" EXACT [] synonym: "panniculus adiposus" BROAD [] synonym: "panniculus adiposus (tela subcutanea)" EXACT [] synonym: "panniculus adiposus telae subcutaneae" EXACT [] synonym: "subcutaneous fat" RELATED [] synonym: "subcutaneous fat layer" EXACT [] is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002194 name: capsule of lymph node synonym: "lymph node capsule" EXACT [] is_a: UBERON:0003893 ! capsule [Term] id: UBERON:0002196 name: adenohypophysis synonym: "AHP" BROAD [] synonym: "anterior hypophysis" EXACT [] synonym: "anterior lobe (hypophysis)" EXACT [] synonym: "anterior lobe of hypophysis" EXACT [] synonym: "anterior lobe of pituitary" EXACT [] synonym: "anterior lobe of pituitary gland" EXACT [] synonym: "anterior lobe of the pituitary" RELATED [] synonym: "anterior pituitary" EXACT [] synonym: "anterior pituitary gland" RELATED [] synonym: "cranial lobe" RELATED [] synonym: "lobus anterior" RELATED [] synonym: "lobus anterior (glandula pituitaria)" EXACT [] synonym: "lobus anterior hypophysis" EXACT [] synonym: "pituitary anterior lobe" RELATED [] synonym: "pituitary gland, anterior lobe" EXACT [] synonym: "pituitary glandanterior lobe" RELATED [] synonym: "rostral lobe" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002200 name: vasculature of head synonym: "adult head vascular network" EXACT [] synonym: "adult head vasculature" EXACT [] synonym: "cranial vasculature" EXACT [] synonym: "head vascular network" EXACT [] synonym: "head vasculature" RELATED [] synonym: "vascular network of adult head" EXACT [] synonym: "vascular network of head" EXACT [] synonym: "vasculature of adult head" EXACT [] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0002201 name: vasculature of trunk synonym: "torso vascular network" EXACT [] synonym: "torso vasculature" EXACT [] synonym: "trunk vascular network" EXACT [] synonym: "trunk vasculature" EXACT [] synonym: "vascular network of torso" EXACT [] synonym: "vascular network of trunk" EXACT [] synonym: "vasculature of torso" EXACT [] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0002203 name: vasculature of eye synonym: "eye vascular network" EXACT [] synonym: "eye vasculature" RELATED [] synonym: "ocular blood vessel" EXACT [] synonym: "ocular vasculature" EXACT [] synonym: "optic vasculature" RELATED [] synonym: "vascular network of eye" EXACT [] is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0006876 ! vasculature of organ [Term] id: UBERON:0002212 name: macula of saccule of membranous labyrinth synonym: "macula of membranous labyrinth saccule" EXACT [] synonym: "macula of saccule" EXACT [] synonym: "macula of sacculus (labyrinthus vestibularis)" EXACT [] synonym: "macula saccule" EXACT [] synonym: "macula sacculi" EXACT [] synonym: "macula sacculi" RELATED [] synonym: "membranous labyrinth saccule macula" EXACT [] synonym: "saccular macula" EXACT [] synonym: "saccular macula of membranous labyrinth" EXACT [] synonym: "saccular maculs" RELATED [] synonym: "saccule macula" EXACT [] synonym: "saccule of membranous labyrinth macula" EXACT [] synonym: "sacculus (labyrinthus vestibularis) macula" EXACT [] is_a: UBERON:0000054 ! macula [Term] id: UBERON:0002214 name: macula of utricle of membranous labyrinth synonym: "macula of membranous labyrinth utricle" EXACT [] synonym: "macula of utricle" EXACT [] synonym: "macula of utriculus (labyrinthus vestibularis)" EXACT [] synonym: "macula utricle" EXACT [] synonym: "macula utriculi" EXACT [] synonym: "macula utriculi" RELATED [] synonym: "membranous labyrinth utricle macula" EXACT [] synonym: "utricle macula" EXACT [] synonym: "utricle of membranous labyrinth macula" EXACT [] synonym: "utricular macula" RELATED [] synonym: "utriculus (labyrinthus vestibularis) macula" EXACT [] is_a: UBERON:0000054 ! macula [Term] id: UBERON:0002217 name: synovial joint synonym: "articulatio synoviale" EXACT [] synonym: "diarthrodial joints" RELATED [] synonym: "diarthroses" EXACT [] synonym: "diarthrosis" EXACT [] synonym: "diarthrosis joint" EXACT [] is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0002227 name: spiral organ of cochlea synonym: "basilar papilla" RELATED [] synonym: "cochlear spiral organ" EXACT [] synonym: "Corti's organ" RELATED [] synonym: "organ of Corti" RELATED [] synonym: "organum spirale" EXACT [] synonym: "papilla basilaris" RELATED [] synonym: "spiral organ" EXACT [] synonym: "spiral organ of Corti" EXACT [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002240 name: spinal cord synonym: "cerebro-cerebellar fissure" RELATED [] synonym: "cerebrocerebellar fissure" RELATED [] synonym: "fissura cerebro-cerebellaris" RELATED [] synonym: "fissura cerebrocerebellaris" RELATED [] synonym: "medulla spinalis" RELATED [] synonym: "SpC" RELATED [] synonym: "spinal cord structure" RELATED [] synonym: "spinal medulla" RELATED [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002242 name: nucleus pulposus synonym: "nucleus propulsus" RELATED [] synonym: "nucleus propulsus of intervertebral disk" RELATED [] synonym: "nucleus pulposus (diskus intervertebralis)" EXACT [] synonym: "nucleus pulposus of intervertebral disk" RELATED [] synonym: "pulpy nucleus" EXACT [] is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0002255 name: vomeronasal organ synonym: "Jacobson's organ" EXACT [] synonym: "organ of Jacobsen" RELATED [] synonym: "organon vomeronasale" EXACT [] synonym: "organum vomeronasale" EXACT [] synonym: "VNO" RELATED [] is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0002256 name: dorsal horn of spinal cord synonym: "cornu dorsale" EXACT [] synonym: "cornu posterius medullae spinalis" EXACT [] synonym: "dorsal gray column of spinal cord" EXACT [] synonym: "dorsal gray horn" EXACT [] synonym: "dorsal gray matter of spinal cord" EXACT [] synonym: "dorsal grey column of spinal cord" EXACT [] synonym: "dorsal grey horn" BROAD [] synonym: "dorsal horn" BROAD [] synonym: "dorsal horn of the spinal cord" RELATED [] synonym: "dorsal horn spinal cord" EXACT [] synonym: "dorsal region of mature spinal cord" BROAD [] synonym: "dorsal region of spinal cord" BROAD [] synonym: "dorsal spinal cord" BROAD [] synonym: "posterior gray column of spinal cord" EXACT [] synonym: "posterior gray horn of spinal cord" EXACT [] synonym: "posterior grey column of spinal cord" EXACT [] synonym: "posterior horn of spinal cord" EXACT [] synonym: "spinal cord dorsal horn" EXACT [] synonym: "spinal cord dorsal horns" RELATED [] synonym: "spinal cord posterior horn" EXACT [] is_a: UBERON:0016550 ! spinal cord column [Term] id: UBERON:0002257 name: ventral horn of spinal cord synonym: "anterior column" RELATED [] synonym: "anterior column of the spinal cord" RELATED [] synonym: "anterior gray column of spinal cord" EXACT [] synonym: "anterior gray horn of spinal cord" EXACT [] synonym: "anterior grey column of spinal cord" EXACT [] synonym: "anterior horn" EXACT [] synonym: "anterior horn (spinal cord)" RELATED [] synonym: "cornu anterius medullae spinalis" RELATED [] synonym: "spinal cord anterior horn" EXACT [] synonym: "spinal cord ventral horn" EXACT [] synonym: "ventral gray column of spinal cord" EXACT [] synonym: "ventral gray matter of spinal cord" EXACT [] synonym: "ventral grey column of spinal cord" EXACT [] synonym: "ventral grey horn" EXACT [] synonym: "ventral horn of the spinal cord" RELATED [] synonym: "ventral horn spinal cord" EXACT [] synonym: "ventral horns spinal cord" RELATED [] synonym: "ventral region of spinal cord" EXACT [] synonym: "ventral spinal cord" EXACT [] is_a: UBERON:0016550 ! spinal cord column [Term] id: UBERON:0002264 name: olfactory bulb synonym: "bulbus olfactorius" EXACT [] synonym: "bulbus olfactorius" RELATED [] synonym: "bulbus olfactorius (Morgagni)" RELATED [] synonym: "olfactory lobe" RELATED [] synonym: "olfactory lobe (Barr & Kiernan)" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0002276 name: lamina of spiral limbus synonym: "limbus lamina spiralis" EXACT [] synonym: "limbus laminae spiralis" EXACT [] synonym: "limbus laminae spiralis osseae" EXACT [] synonym: "spiral limbus" RELATED [] synonym: "spiral limbus lamina" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002282 name: stria vascularis of cochlear duct synonym: "psalterial cord" EXACT [] synonym: "stria vascularis" EXACT [] synonym: "stria vascularis ductus cochlearis" RELATED [] synonym: "stria vascularis of cochlea" EXACT [] synonym: "vascular stria of cochlear duct" RELATED [] synonym: "vascular stripe of cochlear duct" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002285 name: telencephalic ventricle synonym: "forebrain ventricle" RELATED [] synonym: "lateral ventricle" EXACT [] synonym: "lateral ventricle of brain" RELATED [] synonym: "lateral ventricles" EXACT [] synonym: "tectal ventricle" RELATED [] synonym: "telencephalic ventricle" EXACT [] synonym: "Telencephalic ventricles" RELATED [] synonym: "telencephalic vesicle" RELATED [] synonym: "telencephalon lateral ventricle" EXACT [] is_a: UBERON:0004086 ! brain ventricle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002298 name: brainstem synonym: "accessory medullary lamina of pallidum" RELATED [] synonym: "brain stem" EXACT [] synonym: "lamella pallidi incompleta" RELATED [] synonym: "lamina medullaris accessoria" RELATED [] synonym: "lamina medullaris incompleta pallidi" RELATED [] synonym: "lamina pallidi incompleta" RELATED [] synonym: "truncus encephali" EXACT [] synonym: "truncus encephalicus" RELATED [] is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002299 name: alveolus of lung synonym: "alveoli" RELATED [] synonym: "alveolus" BROAD [] synonym: "alveolus pulmonis" EXACT [] synonym: "alveolus pulmonis" RELATED [] synonym: "lung alveolus" EXACT [] synonym: "pulmonary alveolus" EXACT [] synonym: "respiratory alveoli" RELATED [] synonym: "respiratory alveolus" EXACT [] is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0002303 name: juxtaglomerular apparatus synonym: "complexus juxtaglomerularis" EXACT [] synonym: "juxtaglomerular complex" EXACT [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0002305 name: layer of hippocampus synonym: "cytoarchitectural fields of hippocampal formation" EXACT [] synonym: "hippocampus layer" EXACT [] is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 ! central nervous system gray matter layer [Term] id: UBERON:0002308 name: nucleus of brain synonym: "brain nucleus" EXACT [] is_a: UBERON:0000125 ! neural nucleus [Term] id: UBERON:0002313 name: hippocampus pyramidal layer synonym: "gyrus occipitalis inferior" RELATED [] synonym: "gyrus occipitalis tertius" RELATED [] synonym: "hippocampal pyramidal cell layer" RELATED [] synonym: "hippocampal pyramidal layer" RELATED [] synonym: "hippocampus pyramidal cell layer" RELATED [] synonym: "hippocampus stratum pyramidale" RELATED [] synonym: "pyramidal cell layer of the hippocampus" EXACT [] synonym: "pyramidal layer of hippocampus" EXACT [] synonym: "stratum pyramidale" EXACT [] synonym: "stratum pyramidale hippocampi" EXACT [] is_a: UBERON:0002305 ! layer of hippocampus [Term] id: UBERON:0002320 name: glomerular mesangium is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002321 name: extraglomerular mesangium is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002323 name: coelemic cavity lumen synonym: "body cavity" RELATED [] synonym: "celom" RELATED [] synonym: "coelom" RELATED [] synonym: "coelome" RELATED [] synonym: "coelomic cavity" EXACT [] synonym: "coelomic cavity lumen" EXACT [] synonym: "hemocoel" RELATED [] synonym: "space of body compartment" EXACT [] synonym: "ventral body cavity" NARROW [] is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0004458 ! body cavity or lining [Term] id: UBERON:0002325 name: epithelium of urethra synonym: "epithelial tissue of urethra" EXACT [] synonym: "urethra epithelial tissue" EXACT [] synonym: "urethra epithelium" EXACT [] synonym: "urethral epithelium" RELATED [] synonym: "urethral plate" RELATED [] synonym: "urethral seam" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0006555 ! excretory tube is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0002328 name: notochord synonym: "embryonic notocord" EXACT [] synonym: "notochorda" RELATED [] synonym: "notocord" EXACT [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0002331 name: umbilical cord synonym: "birth cord" RELATED [] synonym: "chorda umbilicalis" EXACT [] synonym: "connecting stalk" RELATED [] synonym: "funiculus umbilicalis" EXACT [] synonym: "funiculus umbilicalis" RELATED [] synonym: "yolk stalk" RELATED [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002335 name: macula densa is_a: UBERON:0008408 ! distal tubular epithelium [Term] id: UBERON:0002342 name: neural crest synonym: "crista neuralis" RELATED [] synonym: "NC" EXACT [] synonym: "neural crest material" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010316 ! germ layer / neural crest [Term] id: UBERON:0002348 name: epicardium synonym: "heart epicardium" EXACT [] synonym: "lamina visceralis pericardii serosi" RELATED [] synonym: "pericardium visceral mesothelium" RELATED [] synonym: "visceral serous pericardium of heart" EXACT [] synonym: "visceral serous pericardium proper" EXACT [] is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005983 ! heart layer [Term] id: UBERON:0002351 name: sinoatrial node synonym: "cardiac pacemaker" EXACT [] synonym: "Koch's node" EXACT [] synonym: "node of Keith-Flack" EXACT [] synonym: "nodus sinuatrialis" EXACT [] synonym: "nodus sinuatrialis" RELATED [] synonym: "SA nodal muscle tissue" EXACT [] synonym: "SA node" EXACT [] synonym: "sinoatrial node" EXACT [] synonym: "sinu-atrial node" EXACT [] synonym: "sinuatrial nodal muscle tissue" EXACT [] synonym: "sinuatrial node" EXACT [] synonym: "sinus node" EXACT [] synonym: "sinus node of Keith and Flack" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart [Term] id: UBERON:0002352 name: atrioventricular node synonym: "A-V node" RELATED [] synonym: "aschoff-tawara node" EXACT [] synonym: "atrio-ventricular node" RELATED [] synonym: "atrioventricular nodal muscle tissue" EXACT [] synonym: "atriovetricular node" RELATED [] synonym: "AV nodal muscle tissue" EXACT [] synonym: "AV node" EXACT [] synonym: "node of Tawara" EXACT [] synonym: "nodus atrioventricularis" RELATED [] is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart [Term] id: UBERON:0002353 name: atrioventricular bundle synonym: "A-V bundle" RELATED [] synonym: "atrio-ventricular bundle" RELATED [] synonym: "atrioventricular bundle muscle tissue" EXACT [] synonym: "atrioventricular fasciculus" EXACT [] synonym: "AV bundle" EXACT [] synonym: "bundle of His" EXACT [] synonym: "fasciculus atrioventricularis" EXACT [] synonym: "His bundle" EXACT [] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle [Term] id: UBERON:0002358 name: peritoneum synonym: "peritonaeum" RELATED [] is_a: UBERON:0000042 ! serous membrane [Term] id: UBERON:0002360 name: meninx synonym: "layer of meninges" EXACT [] synonym: "meningeal layer" EXACT [] synonym: "meninx primitiva" NARROW [] is_a: UBERON:0000094 ! membrane organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002363 name: dura mater synonym: "dura" RELATED [] synonym: "dura mater of neuraxis" EXACT [] synonym: "pachymeninges" EXACT [] is_a: UBERON:0002360 ! meninx is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002364 name: tympanic membrane synonym: "ear drum" EXACT [] synonym: "eardrum" EXACT [] synonym: "lateral wall of tympanic cavity" EXACT [] synonym: "membranous wall of tympanic cavity" EXACT [] synonym: "myrinx" EXACT [] synonym: "paries membranaceus cavi tympani" EXACT [] synonym: "Rivinus' membrane" EXACT [] synonym: "tympanum" RELATED [] is_a: UBERON:0000094 ! membrane organ is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002365 name: exocrine gland synonym: "ducted gland" EXACT [] synonym: "glandula exocrina" EXACT [] is_a: UBERON:0002530 ! gland [Term] id: UBERON:0002367 name: prostate gland synonym: "male prostate" EXACT [] synonym: "prostata" RELATED [] synonym: "prostate" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0010147 ! male accessory sex gland [Term] id: UBERON:0002368 name: endocrine gland synonym: "ductless gland" EXACT [] synonym: "ductless gland" RELATED [] synonym: "glandula endocrina" EXACT [] synonym: "glandulae endocrinae" RELATED [] is_a: UBERON:0002530 ! gland [Term] id: UBERON:0002369 name: adrenal gland synonym: "adrenal" RELATED [] synonym: "adrenal capsule" RELATED [] synonym: "adrenal medulla cell" RELATED [] synonym: "atrabiliary capsule" RELATED [] synonym: "epinephric gland" RELATED [] synonym: "epinephros" RELATED [] synonym: "glandula adrenalis" EXACT [] synonym: "glandula suprarenalis" EXACT [] synonym: "glandula suprarenalis" RELATED [] synonym: "interrenal gland" RELATED [] synonym: "suprarenal capsule" RELATED [] synonym: "suprarenal gland" RELATED [] is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006858 ! adrenal/interrenal gland is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0002370 name: thymus synonym: "thymus gland" EXACT [] synonym: "thymus organ" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0005058 ! hemolymphoid system gland [Term] id: UBERON:0002371 name: bone marrow synonym: "medulla of bone" RELATED [] synonym: "medulla ossea" EXACT [] synonym: "medulla ossium" EXACT [] is_a: UBERON:0012429 ! hemopoietic tissue [Term] id: UBERON:0002372 name: tonsil synonym: "Mandel" RELATED [] is_a: UBERON:0001962 ! gut-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0002384 name: connective tissue synonym: "Bindegewebe" RELATED [] synonym: "portion of connective tissue" EXACT [] synonym: "textus connectivus" EXACT [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0002385 name: muscle tissue synonym: "muscular tissue" EXACT [] synonym: "portion of muscle tissue" EXACT [] synonym: "textus muscularis" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0002392 name: nasolacrimal duct synonym: "d. nasolacrimalis" RELATED [] synonym: "nasolacrimal duct - posterior naris" BROAD [] synonym: "tear duct" RELATED [] is_a: UBERON:0000058 ! duct is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0002394 name: bile duct synonym: "bile tube" RELATED [] synonym: "biliary duct" RELATED [] synonym: "gall duct" RELATED [] synonym: "hepatic duct" RELATED [] is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0002400 name: parietal pleura synonym: "pleura parietalis" RELATED [] is_a: UBERON:0000977 ! pleura is_a: UBERON:0022351 ! parietal serous membrane [Term] id: UBERON:0002401 name: visceral pleura synonym: "lung mesothelium" RELATED [] synonym: "lung pleura" RELATED [] synonym: "pleura pulmonalis" EXACT [] synonym: "pleura visceralis" EXACT [] synonym: "pleura visceralis (pulmonalis)" EXACT [] synonym: "pulmonary pleura" EXACT [] is_a: UBERON:0000977 ! pleura is_a: UBERON:0022351 ! parietal serous membrane [Term] id: UBERON:0002405 name: immune system is_a: UBERON:0000467 ! anatomical system [Term] id: UBERON:0002407 name: pericardium is_a: UBERON:0004457 ! cavity lining is_a: UBERON:0006914 ! squamous epithelium [Term] id: UBERON:0002410 name: autonomic nervous system synonym: "ANS" RELATED [] synonym: "autonomic division of peripheral nervous system" EXACT [] synonym: "autonomic part of peripheral nervous system" EXACT [] synonym: "divisio autonomica systematis nervosi peripherici" EXACT [] synonym: "divisio autonomica systematis nervosi peripherici" RELATED [] synonym: "pars autonomica systematis nervosi peripherici" EXACT [] synonym: "peripheral autonomic nervous system" EXACT [] synonym: "visceral nervous system" EXACT [] is_a: UBERON:0011216 ! organ system subdivision [Term] id: UBERON:0002412 name: vertebra synonym: "vertebra bone" EXACT [] synonym: "vertebrae" EXACT [] is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0008001 ! irregular bone is_a: UBERON:0010913 ! vertebral element is_a: UBERON:0015005 ! vertebra endochondral element [Term] id: UBERON:0002418 name: cartilage tissue synonym: "cartilage" RELATED [] synonym: "cartilage tissue" EXACT [] synonym: "cartilages" RELATED [] synonym: "cartilaginous tissue" EXACT [] synonym: "chondrogenic tissue" EXACT [] is_a: UBERON:0004755 ! skeletal tissue [Term] id: UBERON:0002419 name: skin gland synonym: "glandulae cutis" EXACT [] synonym: "set of skin glands" RELATED [] synonym: "skin glands" RELATED [] synonym: "skin glands set" RELATED [] is_a: UBERON:0003297 ! gland of integumental system is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006003 ! integumentary adnexa [Term] id: UBERON:0002424 name: oral epithelium synonym: "epithelium of mucosa of mouth" EXACT [] synonym: "epithelium of oral mucosa" EXACT [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0002428 name: limb bone synonym: "bone of extremity" EXACT [] synonym: "bone of limb" EXACT [] synonym: "free limb bone" EXACT [] is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0004375 ! bone of free limb or fin is_a: UBERON:0015061 ! limb endochondral element [Term] id: UBERON:0002435 name: striatum synonym: "caudate putamen" RELATED [] synonym: "corpus striatum" RELATED [] synonym: "corpus striatum (Zilles)" RELATED [] synonym: "dorsal striatum" RELATED [] synonym: "neostriatum" EXACT [] synonym: "neuraxis striatum" EXACT [] synonym: "striate nucleus" EXACT [] synonym: "striated nucleus" RELATED [] synonym: "striatum" EXACT [] synonym: "striatum of neuraxis" EXACT [] is_a: UBERON:0011300 ! gray matter of telencephalon [Term] id: UBERON:0002450 name: decidua synonym: "decidous membrane" EXACT [] synonym: "decidua basalis" RELATED [] synonym: "endometrium" RELATED [] synonym: "extraembryonic part of placenta" RELATED [] synonym: "extraembryonic placenta" RELATED [] synonym: "maternal decidual layer" RELATED [] synonym: "maternal part of placenta" RELATED [] synonym: "maternal placenta" RELATED [] synonym: "placenta maternal decidual layer" RELATED [] synonym: "uterine decidua" RELATED [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0002456 name: internal thoracic artery synonym: "arteria mammaria interna" RELATED [] synonym: "arteria thoracica interna" RELATED [] synonym: "internal mammary artery" EXACT [] synonym: "internal thoracic mammary artery" EXACT [] synonym: "mammary artery" RELATED [] is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0002472 name: stylopod synonym: "propodium" EXACT [] synonym: "proximal free limb segment" EXACT [] synonym: "proximal part of limb" BROAD [] synonym: "proximal segment of free limb" RELATED [] synonym: "stylopodial limb segment" EXACT [] synonym: "stylopodium" EXACT [] is_a: UBERON:0002529 ! limb segment [Term] id: UBERON:0002481 name: bone tissue synonym: "bone" RELATED [] synonym: "calcium tissue" EXACT [] synonym: "mineralized bone tissue" NARROW [] synonym: "osseous tissue" EXACT [] synonym: "osteogenic tissue" EXACT [] is_a: UBERON:0004755 ! skeletal tissue [Term] id: UBERON:0002485 name: prostate duct synonym: "duct of prostate" EXACT [] synonym: "duct of prostate gland" EXACT [] synonym: "prostate duct" EXACT [] synonym: "prostate gland duct" EXACT [] synonym: "prostatic duct" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system [Term] id: UBERON:0002495 name: long bone synonym: "os longum" RELATED [] is_a: UBERON:0001474 ! bone element [Term] id: UBERON:0002506 name: iris epithelium synonym: "epithelial tissue of iris" EXACT [] synonym: "epithelium of iris" EXACT [] synonym: "epithelium pigmentosum (iris)" EXACT [] synonym: "epithelium pigmentosum iridis" EXACT [] synonym: "iris epithelial tissue" EXACT [] synonym: "iris epithelium" EXACT [] synonym: "iris pigmented epithelium" RELATED [] synonym: "pigmented epithelium of iris" EXACT [] is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium [Term] id: UBERON:0002512 name: corpus luteum synonym: "corpora lutea" EXACT [] synonym: "corpus luteum of ovary" EXACT [] synonym: "luteal gland" RELATED [] synonym: "ovarian corpus luteum" EXACT [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0005398 ! female reproductive gland [Term] id: UBERON:0002513 name: endochondral bone synonym: "cartilaginous bone" RELATED [] synonym: "ossified chondrogenic bone" EXACT [] is_a: UBERON:0001474 ! bone element is_a: UBERON:0010363 ! endochondral element [Term] id: UBERON:0002521 name: elastic tissue synonym: "elastic connective tissue" EXACT [] synonym: "elastic fiber" NARROW [] synonym: "textus connectivus elasticus" EXACT [] is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0002523 name: tunica intima synonym: "Bichat's tunic" RELATED [] synonym: "intima" RELATED [] synonym: "tunica intima vasorum" RELATED [] is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004797 ! blood vessel layer [Term] id: UBERON:0002529 name: limb segment synonym: "extremity part" RELATED [] synonym: "free limb segment" EXACT [] synonym: "limb region" RELATED [] synonym: "region of limb" RELATED [] synonym: "segment of limb" EXACT [] synonym: "subdivision of limb" EXACT [] is_a: UBERON:0010538 ! paired limb/fin segment [Term] id: UBERON:0002530 name: gland synonym: "Druese" RELATED [] synonym: "glandula" RELATED [] synonym: "glandular organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0002553 name: anatomical cavity synonym: "cavity" BROAD [] is_a: UBERON:0000464 ! anatomical space [Term] id: UBERON:0002616 name: regional part of brain synonym: "anatomical structure of brain" EXACT [] synonym: "biological structure of brain" EXACT [] synonym: "brain anatomical structure" EXACT [] synonym: "brain biological structure" EXACT [] synonym: "brain part" EXACT [] synonym: "neuraxis segment" EXACT [] synonym: "neuroanatomical region" EXACT [] synonym: "segment of brain" EXACT [] is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0003037 name: septum synonym: "septa" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0003055 name: periderm synonym: "epidermis epithelial layer" RELATED [] synonym: "epidermis outer layer" RELATED [] synonym: "epitrichium" RELATED [] synonym: "EVL" RELATED [] synonym: "periderm" RELATED [] synonym: "skin periderm" EXACT [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0003059 name: presomitic mesoderm synonym: "presumptive somite mesoderm" RELATED [] synonym: "PSM" RELATED [] synonym: "segmental plate" EXACT [] synonym: "somitogenic mesoderm" RELATED [] synonym: "somitomeric mesoderm" RELATED [] synonym: "unsegmented mesenchyme" RELATED [] synonym: "unsegmented paraxial mesoderm" EXACT [] is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0003102 name: surface structure synonym: "anatomical surface feature" EXACT [] synonym: "surface feature" RELATED [] synonym: "surface region" RELATED [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0003103 name: compound organ synonym: "organ" RELATED [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0003104 name: mesenchyme synonym: "mesenchyma" RELATED [] synonym: "mesenchymal tissue" EXACT [] synonym: "mesenchyme tissue" EXACT [] synonym: "portion of mesenchymal tissue" EXACT [] synonym: "portion of mesenchyme tissue" EXACT [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0003124 name: chorion synonym: "chorion (vertebrates)" EXACT [] synonym: "chorion frondosum" RELATED [] synonym: "chorionic sac" RELATED [] synonym: "embryonic chorion" EXACT [] synonym: "fetal chorion" EXACT [] synonym: "uterine chorion" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane [Term] id: UBERON:0003126 name: trachea synonym: "cartilaginous trachea" EXACT [] synonym: "tracheal tubule" RELATED [] synonym: "vertebrate trachea" EXACT [] synonym: "windpipe" EXACT [] is_a: UBERON:0000117 ! respiratory tube [Term] id: UBERON:0003129 name: skull synonym: "cranial skeleton" RELATED [] synonym: "skeletal system of head" RELATED [] is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0003133 name: reproductive organ synonym: "genital organ" EXACT [] synonym: "genitalia" RELATED [] synonym: "reproductive system organ" EXACT [] synonym: "sex organ" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0003134 name: female reproductive organ synonym: "female organism reproductive organ" EXACT [] synonym: "female organism reproductive structure" EXACT [] synonym: "female organism reproductive system organ" EXACT [] synonym: "female organism sex organ" EXACT [] synonym: "female reproductive gland/organ" EXACT [] synonym: "female reproductive system organ" EXACT [] synonym: "female sex organ" EXACT [] synonym: "reproductive organ of female organism" EXACT [] synonym: "reproductive structure of female organism" EXACT [] synonym: "reproductive system organ of female organism" EXACT [] synonym: "sex organ of female organism" EXACT [] is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0003135 name: male reproductive organ synonym: "male organism reproductive organ" EXACT [] synonym: "male organism reproductive structure" EXACT [] synonym: "male organism reproductive system organ" EXACT [] synonym: "male organism sex organ" EXACT [] synonym: "male reproductive gland/organ" EXACT [] synonym: "male reproductive system organ" EXACT [] synonym: "male sex organ" EXACT [] synonym: "reproductive organ of male organism" EXACT [] synonym: "reproductive structure of male organism" EXACT [] synonym: "reproductive system organ of male organism" EXACT [] synonym: "sex organ of male organism" EXACT [] is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0003210 name: blood-cerebrospinal fluid barrier is_a: UBERON:0000119 ! cell layer [Term] id: UBERON:0003214 name: mammary gland alveolus synonym: "alveolus of lactiferous gland" EXACT [] synonym: "alveolus of lobe of breast" EXACT [] synonym: "alveolus of lobe of mammary gland" EXACT [] synonym: "alveolus of mammary gland" EXACT [] synonym: "lactiferous alveolus" EXACT [] synonym: "lactiferous gland alveolus" EXACT [] synonym: "lobe of breast alveolus" EXACT [] synonym: "lobe of mammary gland alveolus" EXACT [] synonym: "mammary alveoli" RELATED [] synonym: "mammary alveolus" EXACT [] is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0003215 name: alveolus is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0003241 name: epithelium of utricle synonym: "epithelial tissue of membranous labyrinth utricle" EXACT [] synonym: "epithelial tissue of utricle" EXACT [] synonym: "epithelial tissue of utricle of membranous labyrinth" EXACT [] synonym: "epithelial tissue of utriculus (labyrinthus vestibularis)" EXACT [] synonym: "epithelium of macula of utricle of membranous labyrinth" NARROW [] synonym: "epithelium of membranous labyrinth utricle" EXACT [] synonym: "epithelium of utricle of membranous labyrinth" EXACT [] synonym: "epithelium of utriculus (labyrinthus vestibularis)" EXACT [] synonym: "membranous labyrinth utricle epithelial tissue" EXACT [] synonym: "membranous labyrinth utricle epithelium" EXACT [] synonym: "utricle epithelial tissue" EXACT [] synonym: "utricle epithelium" EXACT [] synonym: "utricle of membranous labyrinth epithelial tissue" EXACT [] synonym: "utricle of membranous labyrinth epithelium" EXACT [] synonym: "utriculus (labyrinthus vestibularis) epithelial tissue" EXACT [] synonym: "utriculus (labyrinthus vestibularis) epithelium" EXACT [] is_a: UBERON:0006932 ! vestibular epithelium [Term] id: UBERON:0003242 name: epithelium of saccule synonym: "epithelial tissue of membranous labyrinth saccule" EXACT [] synonym: "epithelial tissue of saccule" EXACT [] synonym: "epithelial tissue of saccule of membranous labyrinth" EXACT [] synonym: "epithelial tissue of sacculus (labyrinthus vestibularis)" EXACT [] synonym: "epithelium of macula of saccule of membranous labyrinth" RELATED [] synonym: "epithelium of membranous labyrinth saccule" EXACT [] synonym: "epithelium of saccule of membranous labyrinth" EXACT [] synonym: "epithelium of sacculus (labyrinthus vestibularis)" EXACT [] synonym: "membranous labyrinth saccule epithelial tissue" EXACT [] synonym: "membranous labyrinth saccule epithelium" EXACT [] synonym: "saccule epithelial tissue" EXACT [] synonym: "saccule epithelium" EXACT [] synonym: "saccule of membranous labyrinth epithelial tissue" EXACT [] synonym: "saccule of membranous labyrinth epithelium" EXACT [] synonym: "sacculus (labyrinthus vestibularis) epithelial tissue" EXACT [] synonym: "sacculus (labyrinthus vestibularis) epithelium" EXACT [] is_a: UBERON:0006932 ! vestibular epithelium [Term] id: UBERON:0003244 name: epithelium of mammary gland synonym: "epithelium of lactiferous gland" EXACT [] synonym: "lactiferous gland epithelium" EXACT [] synonym: "mammary epithelium" EXACT [] synonym: "mammary gland epithelial tissue" EXACT [] synonym: "mammary gland epithelium" EXACT [] is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0003273 name: obsolete skeletal muscle tissue of tongue is_obsolete: true [Term] id: UBERON:0003294 name: gland of foregut synonym: "foregut gland" EXACT [] is_a: UBERON:0003408 ! gland of gut [Term] id: UBERON:0003296 name: gland of diencephalon synonym: "diencephalon gland" EXACT [] synonym: "interbrain gland" EXACT [] is_a: UBERON:0002530 ! gland is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0003297 name: gland of integumental system synonym: "integumental gland" EXACT [] synonym: "integumental system gland" EXACT [] synonym: "integumentary gland" EXACT [] is_a: UBERON:0002530 ! gland [Term] id: UBERON:0003350 name: epithelium of mucosa synonym: "lamina epithelialis mucosa" RELATED [] synonym: "lamina epithelialis mucosae" RELATED [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0003351 name: pharyngeal epithelium synonym: "epithelial tissue of pharynx" EXACT [] synonym: "epithelium of pharynx" EXACT [] synonym: "pharynx epithelial tissue" EXACT [] synonym: "pharynx epithelium" EXACT [] is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium [Term] id: UBERON:0003354 name: epithelium of rectum synonym: "epithelial tissue of rectum" EXACT [] synonym: "rectal epithelium" EXACT [] synonym: "rectum epithelial tissue" EXACT [] synonym: "rectum epithelium" EXACT [] is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0016885 ! epithelium of terminal part of digestive tract [Term] id: UBERON:0003367 name: epithelium of vomeronasal organ synonym: "epithelial tissue of Jacobson's organ" EXACT [] synonym: "epithelial tissue of vomeronasal organ" EXACT [] synonym: "epithelium of Jacobson's organ" EXACT [] synonym: "Jacobson's organ epithelial tissue" EXACT [] synonym: "Jacobson's organ epithelium" EXACT [] synonym: "vomeronasal epithelium" EXACT [] synonym: "vomeronasal organ epithelial tissue" EXACT [] synonym: "vomeronasal organ epithelium" EXACT [] synonym: "vomeronasal organ sensory epithelium" EXACT [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0019306 ! nose epithelium [Term] id: UBERON:0003386 name: smooth muscle of eye synonym: "ocular smooth muscle" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0003408 name: gland of gut synonym: "digestive tract gland" EXACT [] synonym: "gland of digestive tract" EXACT [] synonym: "gland of lower gastrointestinal tract" EXACT [] synonym: "gut gland" EXACT [] synonym: "lower gastrointestinal tract gland" EXACT [] is_a: UBERON:0002530 ! gland is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0003422 name: mesenchyme of umbilical cord synonym: "umbilical cord mesenchyme" EXACT [] synonym: "Wharton's jelly" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue [Term] id: UBERON:0003454 name: small intestine Peyer's patch synonym: "aggregated lymphoid follicle of small intestine" EXACT [] synonym: "noduli lymphoidei aggregati intestini tenuis" EXACT [] synonym: "Peyer's patch" BROAD [] synonym: "Peyer's patch of small bowel" EXACT [] synonym: "Peyer's patch of small intestine" EXACT [] synonym: "small bowel Peyer's patch" EXACT [] synonym: "small intestine Peyer's patch" EXACT [] is_a: UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0003464 name: hindlimb bone synonym: "bone of hind limb" EXACT [] synonym: "bone of hindlimb" EXACT [] synonym: "bone of inferior member" EXACT [] synonym: "bone of lower extremity" EXACT [] synonym: "bone organ of hind limb" EXACT [] synonym: "bone organ of hindlimb" EXACT [] synonym: "bone organ of inferior member" EXACT [] synonym: "bone organ of lower extremity" EXACT [] synonym: "hind limb bone" EXACT [] synonym: "hind limb bone organ" EXACT [] synonym: "hindlimb bone organ" EXACT [] synonym: "inferior member bone" EXACT [] synonym: "inferior member bone organ" EXACT [] synonym: "lower extremity bone" EXACT [] synonym: "lower extremity bone organ" EXACT [] is_a: UBERON:0002428 ! limb bone is_a: UBERON:0010742 ! bone of pelvic complex is_a: UBERON:0015022 ! hindlimb endochondral element [Term] id: UBERON:0003487 name: skin sebaceous gland synonym: "cutaneous sebaceous gland" EXACT [] synonym: "sebaceous gland of skin" EXACT [] is_a: UBERON:0001821 ! sebaceous gland [Term] id: UBERON:0003497 name: abdomen blood vessel synonym: "blood vessel of abdomen" EXACT [] is_a: UBERON:0003835 ! abdominal segment blood vessel [Term] id: UBERON:0003498 name: heart blood vessel synonym: "blood vessel of heart" EXACT [] synonym: "cardiac blood vessel" RELATED [] is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0005985 ! coronary vessel [Term] id: UBERON:0003509 name: arterial blood vessel is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0003513 name: trunk blood vessel synonym: "blood vessel of torso" EXACT [] synonym: "blood vessel of trunk" EXACT [] synonym: "torso blood vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0003517 name: kidney blood vessel synonym: "blood vessel of kidney" EXACT [] synonym: "renal blood vessel" EXACT [] is_a: UBERON:0003497 ! abdomen blood vessel [Term] id: UBERON:0003527 name: kidney capillary synonym: "blood capillary of kidney" EXACT [] synonym: "capillary of kidney" EXACT [] synonym: "capillary vessel of kidney" EXACT [] synonym: "kidney blood capillary" EXACT [] synonym: "kidney capillary vessel" EXACT [] synonym: "renal capillary" EXACT [] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003517 ! kidney blood vessel [Term] id: UBERON:0003528 name: brain gray matter synonym: "brain grey matter" EXACT [] synonym: "brain grey substance" EXACT [] synonym: "gray matter of brain" EXACT [] synonym: "grey matter of brain" EXACT [] synonym: "grey substance of brain" EXACT [] is_a: UBERON:0002020 ! gray matter [Term] id: UBERON:0003530 name: pedal digit skin synonym: "digit of foot skin" EXACT [] synonym: "digit of terminal segment of free lower limb skin" EXACT [] synonym: "digitus pedis skin" EXACT [] synonym: "foot digit skin" EXACT [] synonym: "foot digit skin" NARROW [] synonym: "hind limb digit skin" EXACT [] synonym: "skin of digit of foot" EXACT [] synonym: "skin of digit of terminal segment of free lower limb" EXACT [] synonym: "skin of digitus pedis" EXACT [] synonym: "skin of foot digit" EXACT [] synonym: "skin of terminal segment of free lower limb digit" EXACT [] synonym: "skin of toe" EXACT [] synonym: "terminal segment of free lower limb digit skin" EXACT [] synonym: "toe skin" EXACT [] is_a: UBERON:0001513 ! skin of pes is_a: UBERON:0015249 ! digit skin [Term] id: UBERON:0003532 name: hindlimb skin synonym: "hind limb skin" EXACT [] synonym: "inferior member skin" EXACT [] synonym: "lower extremity skin" EXACT [] synonym: "lower limb skin" EXACT [] synonym: "skin of hind limb" EXACT [] synonym: "skin of hindlimb" EXACT [] synonym: "skin of inferior member" EXACT [] synonym: "skin of lower extremity" EXACT [] synonym: "skin of lower limb" EXACT [] is_a: UBERON:0001419 ! skin of limb [Term] id: UBERON:0003606 name: limb long bone synonym: "long bone of limb" EXACT [] is_a: UBERON:0002428 ! limb bone is_a: UBERON:0002495 ! long bone [Term] id: UBERON:0003608 name: hindlimb long bone synonym: "hind limb long bone" EXACT [] synonym: "inferior member long bone" EXACT [] synonym: "long bone of hind limb" EXACT [] synonym: "long bone of hindlimb" EXACT [] synonym: "long bone of inferior member" EXACT [] synonym: "long bone of lower extremity" EXACT [] synonym: "lower extremity long bone" EXACT [] is_a: UBERON:0003464 ! hindlimb bone is_a: UBERON:0003606 ! limb long bone [Term] id: UBERON:0003644 name: kidney arterial blood vessel synonym: "kidney arterial system" RELATED [] is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:0003517 ! kidney blood vessel [Term] id: UBERON:0003657 name: limb joint synonym: "joint of limb" EXACT [] synonym: "joint of limb skeletal system" EXACT [] synonym: "skeletal limb joint" EXACT [] is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0003688 name: omentum is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0003729 name: mouth mucosa synonym: "buccal mucosa" RELATED [] synonym: "mouth mucosa" EXACT [] synonym: "mouth mucous membrane" EXACT [] synonym: "mouth organ mucosa" EXACT [] synonym: "mucosa of mouth" EXACT [] synonym: "mucosal lining of mouth" RELATED [] synonym: "mucous membrane of mouth" EXACT [] synonym: "oral mucosa" RELATED [] synonym: "oral mucous membrane" EXACT [] synonym: "oral part of viscerocranial mucosa" EXACT [] synonym: "tunica mucosa oris" EXACT [] synonym: "tunica mucosa oris" RELATED [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0003826 name: upper leg bone synonym: "femur" RELATED [] is_a: UBERON:0005893 ! leg bone [Term] id: UBERON:0003834 name: thoracic segment blood vessel synonym: "blood vessel of thorax" EXACT [] synonym: "thorax blood vessel" EXACT [] synonym: "upper body blood vessel" RELATED [] is_a: UBERON:0003513 ! trunk blood vessel [Term] id: UBERON:0003835 name: abdominal segment blood vessel synonym: "abdominal segment of trunk blood vessel" EXACT [] synonym: "blood vessel of abdominal segment of trunk" EXACT [] is_a: UBERON:0003513 ! trunk blood vessel [Term] id: UBERON:0003836 name: abdominal segment skin synonym: "abdominal segment of trunk skin" EXACT [] synonym: "skin of abdominal segment of trunk" EXACT [] is_a: UBERON:0001085 ! skin of trunk [Term] id: UBERON:0003840 name: hindlimb joint synonym: "hind limb joint of limb" EXACT [] synonym: "hind limb limb joint" EXACT [] synonym: "hindlimb joint of limb" EXACT [] synonym: "hindlimb limb joint" EXACT [] synonym: "inferior member joint of limb" EXACT [] synonym: "inferior member limb joint" EXACT [] synonym: "joint of free lower limb" EXACT [] synonym: "joint of limb of hind limb" EXACT [] synonym: "joint of limb of hindlimb" EXACT [] synonym: "joint of limb of inferior member" EXACT [] synonym: "joint of limb of lower extremity" EXACT [] synonym: "joint of lower limb" EXACT [] synonym: "limb joint of hind limb" EXACT [] synonym: "limb joint of hindlimb" EXACT [] synonym: "limb joint of inferior member" EXACT [] synonym: "limb joint of lower extremity" EXACT [] synonym: "lower extremity joint of limb" EXACT [] synonym: "lower extremity limb joint" EXACT [] is_a: UBERON:0003657 ! limb joint [Term] id: UBERON:0003856 name: odontogenic mesenchyme synonym: "dental mesenchyme" EXACT [] synonym: "dental organ mesenchyme" EXACT [] synonym: "enamel organ mesenchyme" EXACT [] synonym: "tooth enamel organ mesenchyme" EXACT [] synonym: "tooth mesenchyme" EXACT [] is_a: UBERON:0007213 ! mesenchyme derived from head neural crest [Term] id: UBERON:0003860 name: hindlimb mesenchyme synonym: "hind limb mesenchyme" EXACT [] synonym: "inferior member mesenchyme" EXACT [] synonym: "lower extremity mesenchyme" EXACT [] synonym: "mesenchyme of hind limb" EXACT [] synonym: "mesenchyme of hindlimb" EXACT [] synonym: "mesenchyme of inferior member" EXACT [] synonym: "mesenchyme of lower extremity" EXACT [] is_a: UBERON:0009749 ! limb mesenchyme [Term] id: UBERON:0003891 name: stroma synonym: "stromal connective tissue" RELATED [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0003893 name: capsule is_a: UBERON:0000158 ! membranous layer [Term] id: UBERON:0003898 name: skeletal muscle tissue of trunk synonym: "skeletal muscle of torso" EXACT [] synonym: "skeletal muscle tissue of torso" EXACT [] synonym: "skeletal muscle tissue of trunk" EXACT [] synonym: "torso skeletal muscle" EXACT [] synonym: "torso skeletal muscle tissue" EXACT [] synonym: "trunk skeletal muscle" EXACT [] synonym: "trunk skeletal muscle tissue" EXACT [] is_a: UBERON:0001134 ! skeletal muscle tissue [Term] id: UBERON:0003902 name: retinal neural layer synonym: "neural layer of retina" EXACT [] synonym: "neural retina" EXACT [] synonym: "neural retinal epithelium" RELATED [] synonym: "neuroretina" EXACT [] synonym: "stratum nervosum (retina)" EXACT [] is_a: UBERON:0001781 ! layer of retina [Term] id: UBERON:0003909 name: sinusoid synonym: "endothelium of irregular blood filled space" RELATED [] synonym: "sinusoidal blood vessel" EXACT [] synonym: "sinusoidal blood vessel endothelium" EXACT [] synonym: "sinusoidal capillary" RELATED [] synonym: "sinusoidal endothelium" RELATED [] is_a: UBERON:2005260 ! fenestrated capillary [Term] id: UBERON:0003914 name: epithelial tube synonym: "epithelial or endothelial tube" EXACT [] is_a: UBERON:0000025 ! tube is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0003915 name: endothelial tube is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003914 ! epithelial tube [Term] id: UBERON:0003920 name: venous blood vessel synonym: "segment of venous tree organ" EXACT [] synonym: "venous tree organ segment" EXACT [] is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0003928 name: digestive system duct synonym: "duct of digestive system" EXACT [] synonym: "duct of gastrointestinal system" EXACT [] synonym: "gastrointestinal system duct" EXACT [] is_a: UBERON:0000058 ! duct [Term] id: UBERON:0003929 name: digestive tract epithelium synonym: "alimentary tract epithelium" RELATED [] synonym: "digestive tract epithelial tissue" EXACT [] synonym: "epithelial tissue of digestive tract" EXACT [] synonym: "epithelial tissue of gut" EXACT [] synonym: "epithelium of digestive tract" EXACT [] synonym: "epithelium of gut" EXACT [] synonym: "gastrodermis" EXACT [] synonym: "gut epithelial tissue" EXACT [] synonym: "gut epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0003937 name: sex gland synonym: "genitalia gland" EXACT [] synonym: "gland of genitalia" EXACT [] synonym: "gland of reproductive system" EXACT [] synonym: "reproductive gland" EXACT [] synonym: "reproductive system gland" EXACT [] is_a: UBERON:0002530 ! gland is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0003947 name: brain ventricle/choroid plexus is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010000 ! multicellular anatomical structure union_of: UBERON:0001886 ! choroid plexus union_of: UBERON:0004086 ! brain ventricle [Term] id: UBERON:0003990 name: spinal cord motor column is_a: UBERON:0016550 ! spinal cord column [Term] id: UBERON:0004001 name: olfactory bulb layer synonym: "cytoarchitectural part of olfactory bulb" EXACT [] is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer [Term] id: UBERON:0004044 name: anterior visceral endoderm synonym: "AVE" RELATED [] is_a: UBERON:0004877 ! visceral endoderm [Term] id: UBERON:0004059 name: spinal cord medial motor column is_a: UBERON:0003990 ! spinal cord motor column [Term] id: UBERON:0004086 name: brain ventricle synonym: "brain ventricles" EXACT [] synonym: "cerebral ventricle" EXACT [] synonym: "region of ventricular system of brain" EXACT [] is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005358 ! ventricle of nervous system [Term] id: UBERON:0004111 name: anatomical conduit synonym: "foramen" NARROW [] synonym: "foramina" NARROW [] synonym: "opening" RELATED [] synonym: "ostia" RELATED [] synonym: "ostium" RELATED [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0004119 name: endoderm-derived structure is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0004120 name: mesoderm-derived structure is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0004121 name: ectoderm-derived structure is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0004129 name: growth plate cartilage synonym: "growth plate" RELATED [] is_a: UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0004134 name: proximal tubule synonym: "kidney proximal tubule" EXACT [] synonym: "proximal kidney tubule" EXACT [] synonym: "renal proximal tubule" EXACT [] is_a: UBERON:0006853 ! renal cortex tubule [Term] id: UBERON:0004135 name: distal tubule synonym: "kidney distal tubule" EXACT [] synonym: "renal distal tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0004136 name: intermediate tubule synonym: "renal intermediate tubule" EXACT [] synonym: "tubulus attenuatus" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0004146 name: His-Purkinje system synonym: "distal conduction system" EXACT [] synonym: "His-Purkinji network" EXACT [] synonym: "HPS" EXACT [] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle [Term] id: UBERON:0004151 name: cardiac chamber synonym: "chamber of heart" EXACT [] synonym: "heart chamber" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0004164 name: branchiomeric muscle synonym: "branchial head muscle" EXACT [] synonym: "branchiomeric skeletal muscle" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0004177 name: hemopoietic organ synonym: "haematological system organ" EXACT [] synonym: "haemopoietic system organ" EXACT [] synonym: "hematopoeitic or lymphoid organ" NARROW [] synonym: "hematopoeitic organ" EXACT [] synonym: "hematopoietic system organ" EXACT [] synonym: "lymph organ" NARROW [] synonym: "lymphoid organ" NARROW [] synonym: "organ of haematological system" EXACT [] synonym: "organ of haemopoietic system" EXACT [] synonym: "organ of hematopoietic system" EXACT [] synonym: "organ of organa haemopoietica" EXACT [] synonym: "organa haemopoietica organ" EXACT [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0004178 name: aorta smooth muscle tissue synonym: "aorta non-striated muscle" EXACT [] synonym: "aorta smooth muscle" EXACT [] synonym: "aortic smooth muscle" EXACT [] is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle [Term] id: UBERON:0004179 name: prostate glandular acinus synonym: "prostatic acinus" EXACT [] synonym: "prostatic follicle" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0009842 ! glandular acinus [Term] id: UBERON:0004186 name: olfactory bulb mitral cell layer synonym: "mitral cell body layer" EXACT [] synonym: "mitral cell layer" EXACT [] synonym: "mitral cell layer of the olfactory bulb" RELATED [] synonym: "OB mitral cell layer" EXACT [] synonym: "olfactory bulb main mitral cell body layer" RELATED [] is_a: UBERON:0004001 ! olfactory bulb layer [Term] id: UBERON:0004188 name: glomerular epithelium synonym: "epithelium of glomerulus" EXACT [] synonym: "epithelium of kidney glomerulus" EXACT [] synonym: "epithelium of renal glomerulus" EXACT [] synonym: "glomerular epithelial cell" RELATED [] synonym: "kidney glomerular epithelium" EXACT [] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0004189 name: glomerular endothelium synonym: "endothelium of renal glomerulus" EXACT [] synonym: "renal glomerulus endothelium" EXACT [] is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0004852 ! cardiovascular system endothelium [Term] id: UBERON:0004193 name: loop of Henle ascending limb thin segment synonym: "ascending limb thin segment of loop of Henle" EXACT [] synonym: "ascending thin limb" EXACT [] synonym: "pars ascendens (tubulus attenuatus)" EXACT [] synonym: "thin ascending limb" EXACT [] synonym: "thin ascending limb of loop of Henle" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0008408 ! distal tubular epithelium [Term] id: UBERON:0004211 name: nephron epithelium synonym: "epithelial tissue of nephron" EXACT [] synonym: "epithelium of nephron" EXACT [] synonym: "nephron epithelial tissue" EXACT [] is_a: UBERON:0004819 ! kidney epithelium [Term] id: UBERON:0004227 name: kidney pelvis smooth muscle synonym: "kidney pelvis smooth muscle" EXACT [] synonym: "pelvic smooth muscle" RELATED [] synonym: "renal pelvis smooth muscle" EXACT [] synonym: "smooth muscle tissue of renal pelvis" EXACT [] is_a: UBERON:0009919 ! ureter smooth muscle [Term] id: UBERON:0004234 name: iris smooth muscle synonym: "involuntary muscle of iris" EXACT [] synonym: "iridial smooth muscle" EXACT [] synonym: "iris involuntary muscle" EXACT [] synonym: "iris non-striated muscle" EXACT [] synonym: "iris smooth muscle tissue" EXACT [] synonym: "non-striated muscle of iris" EXACT [] synonym: "smooth muscle of iris" EXACT [] synonym: "smooth muscle tissue of iris" EXACT [] is_a: UBERON:0003386 ! smooth muscle of eye [Term] id: UBERON:0004237 name: blood vessel smooth muscle synonym: "blood vessel involuntary muscle" EXACT [] synonym: "blood vessel non-striated muscle" EXACT [] synonym: "blood vessel smooth muscle tissue" EXACT [] synonym: "involuntary muscle of blood vessel" EXACT [] synonym: "non-striated muscle of blood vessel" EXACT [] synonym: "smooth muscle of blood vessel" EXACT [] synonym: "smooth muscle tissue of blood vessel" EXACT [] synonym: "vascular smooth muscle" EXACT [] synonym: "vascular smooth muscle tissue" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue [Term] id: UBERON:0004262 name: upper leg skin synonym: "hind limb stylopod skin" EXACT [] synonym: "hindlimb stylopod skin" EXACT [] synonym: "inferior member stylopod skin" EXACT [] synonym: "lower extremity stylopod skin" EXACT [] synonym: "Proximal segment of free lower limb skin" EXACT [] synonym: "skin of hind limb stylopod" EXACT [] synonym: "skin of hindlimb stylopod" EXACT [] synonym: "skin of inferior member stylopod" EXACT [] synonym: "skin of lower extremity stylopod" EXACT [] synonym: "skin of Proximal segment of free lower limb" EXACT [] synonym: "skin of stylopod of hind limb" EXACT [] synonym: "skin of stylopod of hindlimb" EXACT [] synonym: "skin of stylopod of inferior member" EXACT [] synonym: "skin of stylopod of lower extremity" EXACT [] synonym: "skin of stylopod of lower limb" EXACT [] synonym: "skin of thigh" EXACT [] synonym: "skin of upper leg" EXACT [] synonym: "stylopod of hind limb skin" EXACT [] synonym: "stylopod of hindlimb skin" EXACT [] synonym: "stylopod of inferior member skin" EXACT [] synonym: "stylopod of lower extremity skin" EXACT [] synonym: "stylopod of lower limb skin" EXACT [] synonym: "thigh skin" EXACT [] is_a: UBERON:0001511 ! skin of leg [Term] id: UBERON:0004277 name: eye muscle is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0004294 name: glomerular capillary endothelium synonym: "renal glomerulus capillary endothelium" EXACT [] is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004189 ! glomerular endothelium [Term] id: UBERON:0004375 name: bone of free limb or fin synonym: "appendage bone" EXACT [] synonym: "bone of appendage" EXACT [] synonym: "bone of free segment of appendicular skeleton" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010740 ! bone of appendage girdle complex [Term] id: UBERON:0004457 name: cavity lining is_a: UBERON:0004458 ! body cavity or lining is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0004458 name: body cavity or lining is_a: UBERON:0001062 ! anatomical entity union_of: UBERON:0002323 ! coelemic cavity lumen union_of: UBERON:0004457 ! cavity lining [Term] id: UBERON:0004491 name: cardiac muscle tissue of interatrial septum synonym: "interatrial septum cardiac muscle tissue" EXACT [] synonym: "interatrial septum heart muscle" EXACT [] synonym: "interatrial septum muscle" EXACT [] synonym: "interatrial septum myocardium" EXACT [] is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum [Term] id: UBERON:0004492 name: cardiac muscle tissue of cardiac septum synonym: "cardiac septum cardiac muscle tissue" EXACT [] synonym: "cardiac septum heart muscle" EXACT [] synonym: "cardiac septum muscle" EXACT [] synonym: "cardiac septum myocardium" EXACT [] is_a: UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0004493 name: cardiac muscle tissue of myocardium is_a: UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0004510 name: skeletal muscle tissue of pectoralis major is_a: UBERON:0003898 ! skeletal muscle tissue of trunk [Term] id: UBERON:0004536 name: lymph vasculature synonym: "lymphatic trunks and ducts" EXACT [] synonym: "lymphatic vasculature" EXACT [] synonym: "lymphatic vessel network" EXACT [] synonym: "lymphatic vessels set" EXACT [] synonym: "set of lymphatic vessels" EXACT [] synonym: "trunci et ductus lymphatici" EXACT [] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0004544 name: epididymis epithelium synonym: "Epididymis epithelium" EXACT [] synonym: "epithelium of epididymis" EXACT [] is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0034969 ! epithelial layer of duct [Term] id: UBERON:0004573 name: systemic artery synonym: "systemic arterial subtree" EXACT [] is_a: UBERON:0001637 ! artery [Term] id: UBERON:0004590 name: sphincter muscle synonym: "circular muscle" RELATED [] synonym: "sphincter" EXACT [] is_a: UBERON:0001630 ! muscle organ [Term] id: UBERON:0004638 name: blood vessel endothelium is_a: UBERON:0004852 ! cardiovascular system endothelium [Term] id: UBERON:0004639 name: renal afferent arteriole synonym: "afferent arteriole" EXACT [] synonym: "afferent glomerular arteriole" EXACT [] synonym: "afferent glomerular arteriole of kidney" EXACT [] synonym: "arteriola glomerularis afferens" RELATED [] synonym: "kidney afferent arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel [Term] id: UBERON:0004640 name: renal efferent arteriole synonym: "arteriola glomerularis efferens capsulae renalis" RELATED [] synonym: "efferent arteriole" EXACT [] synonym: "efferent glomerular arteriole" EXACT [] synonym: "efferent glomerular arteriole of kidney" EXACT [] synonym: "kidney efferent arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel [Term] id: UBERON:0004645 name: urinary bladder urothelium synonym: "bladder transitional cell epithelium" EXACT [] synonym: "epithelium of bladder" RELATED [] synonym: "transitional epithelium" RELATED [] synonym: "transitional epithelium of urinary bladder" EXACT [] synonym: "urinary bladder transitional epithelium" EXACT [] synonym: "urothelium" BROAD [] synonym: "urothelium of urinary bladder" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000365 ! urothelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0004664 name: aorta tunica adventitia synonym: "tunica adventitia of aorta" EXACT [] is_a: UBERON:0005734 ! tunica adventitia of blood vessel [Term] id: UBERON:0004684 name: raphe nuclei synonym: "nuclei raphes" EXACT [] synonym: "nuclei raphes" RELATED [] synonym: "raphe cluster" RELATED [] synonym: "raphe nuclei" EXACT [] synonym: "raphe nuclei set" EXACT [] synonym: "raphe nucleus" RELATED [] synonym: "Raphe of mesenchephalon" RELATED [] synonym: "set of raphe nuclei" RELATED [] is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0004695 name: arterial system smooth muscle is_a: UBERON:0001135 ! smooth muscle tissue [Term] id: UBERON:0004700 name: arterial system endothelium is_a: UBERON:0004852 ! cardiovascular system endothelium [Term] id: UBERON:0004708 name: paired limb/fin synonym: "girdle-associated appendage" EXACT [] synonym: "jointed paired lateral appendage" NARROW [] synonym: "limb or fin" EXACT [] synonym: "limb/fin" EXACT [] synonym: "paired appendage" NARROW [] synonym: "pectoral or pelvic appendage" EXACT [] synonym: "pelvic/pectoral appendage" EXACT [] is_a: UBERON:0000026 ! appendage [Term] id: UBERON:0004715 name: annulus fibrosus disci intervertebralis synonym: "annulus fibrosus" BROAD [] synonym: "annulus fibrosus of intervertebral disc" RELATED [] synonym: "anulus fibrosus (diskus intervertebralis)" EXACT [] synonym: "anulus fibrosus of intervertebral disk" EXACT [] synonym: "fibrous ring of intervertebral disc" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006444 ! annulus fibrosus [Term] id: UBERON:0004719 name: kidney arcuate vein synonym: "arciform vein of kidney" EXACT [] synonym: "arcuate vein" BROAD [] synonym: "arcuate vein of kidney" EXACT [] synonym: "arcuate veins" RELATED [] synonym: "renal arcuate vein" EXACT [] synonym: "venae arcuatae renis" EXACT [] is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel [Term] id: UBERON:0004723 name: interlobular artery synonym: "arteriae corticales radiatae" RELATED [] synonym: "arteriae interlobulares renis" RELATED [] synonym: "cortical radial arteries" RELATED [] synonym: "interlobular" RELATED [] synonym: "interlobular renal artery" EXACT [] synonym: "kidney interlobular artery" EXACT [] is_a: UBERON:0003644 ! kidney arterial blood vessel [Term] id: UBERON:0004726 name: vasa recta synonym: "arteria recta" RELATED [] synonym: "arteriae rectae" RELATED [] synonym: "arteriolae rectae renis" EXACT [] synonym: "arteriolae rectae renis" RELATED [] synonym: "arteriolae recti" RELATED [] synonym: "kidney vasa recta" EXACT [] synonym: "renal medullary capillary" EXACT [] synonym: "set of straight arterioles of kidney" EXACT [] synonym: "straight arterioles of kidney" EXACT [] synonym: "vasa recta of kidney" EXACT [] synonym: "vasa recta renis" EXACT [] synonym: "vasa rectae" RELATED [] is_a: UBERON:0001140 ! renal vein [Term] id: UBERON:0004734 name: gastrula synonym: "blastocystis trilaminaris" RELATED [] synonym: "gastrula embryo" EXACT [] synonym: "tri-laminar disc" RELATED [] synonym: "tri-laminar disk" RELATED [] synonym: "trilaminar blastocyst" RELATED [] synonym: "trilaminar blastoderm" RELATED [] synonym: "trilaminar disc" RELATED [] synonym: "trilaminar disk" RELATED [] synonym: "trilaminar germ" RELATED [] is_a: UBERON:0000922 ! embryo [Term] id: UBERON:0004755 name: skeletal tissue is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0004765 name: skeletal element is_a: UBERON:0000062 ! organ [Term] id: UBERON:0004775 name: outer renal medulla vasa recta synonym: "kidney outer medulla vasa recta" EXACT [] synonym: "kidney outer renal medulla vasa recta" EXACT [] synonym: "outer medulla of kidney vasa recta" EXACT [] synonym: "outer zone of medulla of kidney vasa recta" EXACT [] synonym: "outer zone of renal medulla vasa recta" EXACT [] synonym: "vasa recta of outer medulla of kidney" EXACT [] synonym: "vasa recta of outer renal medulla" EXACT [] synonym: "vasa recta of outer zone of medulla of kidney" EXACT [] synonym: "vasa recta of outer zone of renal medulla" EXACT [] is_a: UBERON:0004726 ! vasa recta is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel [Term] id: UBERON:0004776 name: inner renal medulla vasa recta synonym: "inner medulla of kidney vasa recta" EXACT [] synonym: "inner zone of medulla of kidney vasa recta" EXACT [] synonym: "inner zone of renal medulla vasa recta" EXACT [] synonym: "set of inner region of renal pyramids vasa recta" EXACT [] synonym: "vasa recta of inner medulla of kidney" EXACT [] synonym: "vasa recta of inner renal medulla" EXACT [] synonym: "vasa recta of inner zone of medulla of kidney" EXACT [] synonym: "vasa recta of inner zone of renal medulla" EXACT [] synonym: "vasa recta of set of inner region of renal pyramids" EXACT [] is_a: UBERON:0004726 ! vasa recta is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel [Term] id: UBERON:0004780 name: gastrointestinal system lamina propria is_a: UBERON:0000030 ! lamina propria [Term] id: UBERON:0004785 name: respiratory system mucosa synonym: "apparatus respiratorius mucosa" EXACT [] synonym: "apparatus respiratorius mucosa of organ" EXACT [] synonym: "apparatus respiratorius mucous membrane" EXACT [] synonym: "laryngeal mucous membrane" RELATED [] synonym: "mucosa of apparatus respiratorius" EXACT [] synonym: "mucosa of organ of apparatus respiratorius" EXACT [] synonym: "mucosa of organ of respiratory system" EXACT [] synonym: "mucosa of respiratory system" EXACT [] synonym: "mucous membrane of apparatus respiratorius" EXACT [] synonym: "mucous membrane of respiratory system" EXACT [] synonym: "respiratory mucosa" RELATED [] synonym: "respiratory system mucosa of organ" EXACT [] synonym: "respiratory system mucous membrane" EXACT [] synonym: "respiratory tract mucosa" RELATED [] is_a: UBERON:0000344 ! mucosa [Term] id: UBERON:0004786 name: gastrointestinal system mucosa synonym: "digestive tract mucosa" EXACT [] synonym: "gut mucosa" EXACT [] synonym: "gut mucuous membrane" EXACT [] synonym: "mucosa of gut" EXACT [] is_a: UBERON:0000344 ! mucosa [Term] id: UBERON:0004787 name: urethra urothelium synonym: "urethra Uroepithelium" EXACT [] synonym: "uroepithelium of urethra" EXACT [] synonym: "urothelium of urethra" EXACT [] is_a: UBERON:0000365 ! urothelium is_a: UBERON:0002325 ! epithelium of urethra [Term] id: UBERON:0004788 name: kidney pelvis urothelium synonym: "kidney pelvis transitional epithelium" EXACT [] synonym: "kidney pelvis Uroepithelium" EXACT [] synonym: "pelvic urothelium" RELATED [] synonym: "pelvis of ureter Uroepithelium" EXACT [] synonym: "pelvis of ureter urothelium" EXACT [] synonym: "renal pelvis transitional epithelium" EXACT [] synonym: "renal pelvis Uroepithelium" EXACT [] synonym: "renal pelvis urothelium" EXACT [] synonym: "transitional epithelium of kidney pelvis" EXACT [] synonym: "transitional epithelium of renal pelvis" EXACT [] synonym: "uroepithelium of kidney pelvis" EXACT [] synonym: "uroepithelium of pelvis of ureter" EXACT [] synonym: "uroepithelium of renal pelvis" EXACT [] synonym: "urothelium of kidney pelvis" EXACT [] synonym: "urothelium of pelvis of ureter" EXACT [] synonym: "urothelium of renal pelvis" EXACT [] is_a: UBERON:0001254 ! urothelium of ureter is_a: UBERON:0004819 ! kidney epithelium [Term] id: UBERON:0004797 name: blood vessel layer is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0004801 name: cervix epithelium synonym: "cervical canal epithelial tissue" EXACT [] synonym: "cervical canal epithelium" EXACT [] synonym: "cervical epithelium" EXACT [] synonym: "cervix epithelial tissue" EXACT [] synonym: "epithelium of cervix" EXACT [] is_a: UBERON:0006955 ! uterine epithelium [Term] id: UBERON:0004802 name: respiratory tract epithelium synonym: "airway epithelium" RELATED [] synonym: "epithelial tissue of respiratory tract" EXACT [] synonym: "epithelium of respiratory tract" EXACT [] synonym: "respiratory epithelium" RELATED [] synonym: "respiratory tract epithelial tissue" EXACT [] is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium [Term] id: UBERON:0004804 name: oviduct epithelium synonym: "columnar epithelium of the Fallopian tube" RELATED [] synonym: "columnar epithelium of the oviduct" RELATED [] synonym: "epithelial tissue of oviduct" EXACT [] synonym: "epithelium of fallopian tube" EXACT [] synonym: "epithelium of oviduct" EXACT [] synonym: "epithelium of uterine tube" EXACT [] synonym: "fallopian tube epithelium" RELATED [] synonym: "oviduct epithelial tissue" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0004805 name: seminal vesicle epithelium synonym: "epithelial tissue of seminal gland" EXACT [] synonym: "epithelial tissue of seminal vesicle" EXACT [] synonym: "epithelium of seminal gland" EXACT [] synonym: "epithelium of seminal vesicle" EXACT [] synonym: "seminal gland epithelial tissue" EXACT [] synonym: "seminal gland epithelium" EXACT [] synonym: "seminal vesicle epithelial tissue" EXACT [] is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0034969 ! epithelial layer of duct [Term] id: UBERON:0004807 name: respiratory system epithelium synonym: "apparatus respiratorius epithelial tissue" EXACT [] synonym: "apparatus respiratorius epithelium" EXACT [] synonym: "epithelial tissue of apparatus respiratorius" EXACT [] synonym: "epithelial tissue of respiratory system" EXACT [] synonym: "epithelium of apparatus respiratorius" EXACT [] synonym: "epithelium of respiratory system" EXACT [] synonym: "respiratory system epithelial tissue" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0004808 name: gastrointestinal system epithelium synonym: "digestive system epithelial tissue" EXACT [] synonym: "digestive system epithelium" EXACT [] synonym: "epithelial tissue of digestive system" EXACT [] synonym: "epithelial tissue of gastrointestinal system" EXACT [] synonym: "epithelium of digestive system" EXACT [] synonym: "epithelium of gastrointestinal system" EXACT [] synonym: "gastrointestinal system epithelial tissue" EXACT [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0004809 name: salivary gland epithelium synonym: "epithelial tissue of salivary gland" EXACT [] synonym: "epithelium of salivary gland" EXACT [] synonym: "salivary gland epithelial tissue" EXACT [] is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0004810 name: nephron tubule epithelium synonym: "epithelial tissue of nephron tubule" EXACT [] synonym: "epithelial tissue of renal tubule" EXACT [] synonym: "epithelial tissue of tubulus renalis" EXACT [] synonym: "epithelium of nephron tubule" EXACT [] synonym: "epithelium of renal tubule" EXACT [] synonym: "epithelium of tubulus renalis" EXACT [] synonym: "kidney tubule epithelium" EXACT [] synonym: "nephron tubule epithelial tissue" EXACT [] synonym: "nephron tubule epithelium" EXACT [] synonym: "renal tubule epithelial tissue" EXACT [] synonym: "tubulus renalis epithelial tissue" EXACT [] synonym: "tubulus renalis epithelium" EXACT [] is_a: UBERON:0004211 ! nephron epithelium [Term] id: UBERON:0004813 name: seminiferous tubule epithelium synonym: "epithelial tissue of seminiferous tubule" EXACT [] synonym: "epithelial tissue of seminiferous tubule of testis" EXACT [] synonym: "epithelium of seminiferous tubule" EXACT [] synonym: "epithelium of seminiferous tubule of testis" EXACT [] synonym: "germinal epithelium (male)" EXACT [] synonym: "male germinal epithelium" EXACT [] synonym: "seminiferous epithelium" EXACT [] synonym: "seminiferous tubule epithelial tissue" EXACT [] synonym: "testis germinal epithelium" EXACT [] synonym: "wall of seminiferous tubule" EXACT [] is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0034969 ! epithelial layer of duct [Term] id: UBERON:0004814 name: upper respiratory tract epithelium synonym: "epithelial tissue of upper respiratory tract" EXACT [] synonym: "epithelium of upper respiratory tract" EXACT [] synonym: "upper respiratory tract epithelial tissue" EXACT [] is_a: UBERON:0004802 ! respiratory tract epithelium [Term] id: UBERON:0004815 name: lower respiratory tract epithelium synonym: "epithelial tissue of lower respiratory tract" EXACT [] synonym: "epithelium of lower respiratory tract" EXACT [] synonym: "lower respiratory tract epithelial tissue" EXACT [] is_a: UBERON:0004802 ! respiratory tract epithelium [Term] id: UBERON:0004819 name: kidney epithelium synonym: "epithelial tissue of kidney" EXACT [] synonym: "epithelium of kidney" EXACT [] synonym: "kidney epithelial tissue" EXACT [] synonym: "renal epithelium" RELATED [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0004820 name: bile duct epithelium synonym: "biliary duct epithelium" EXACT [] synonym: "epithelium of bile duct" EXACT [] synonym: "epithelium of biliary duct" EXACT [] is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0034932 ! epithelium of biliary system is_a: UBERON:0034969 ! epithelial layer of duct [Term] id: UBERON:0004821 name: pulmonary alveolus epithelium synonym: "alveolar epithelium" RELATED [] synonym: "alveolus epithelial tissue" EXACT [] synonym: "alveolus epithelium" EXACT [] synonym: "epithelial tissue of alveolus" EXACT [] synonym: "epithelium of alveolus" EXACT [] synonym: "epithelium of pulmonary alveolus" EXACT [] synonym: "pulmonary alveolar epithelium" EXACT [] synonym: "pulmonary alveolus epithelium" EXACT [] is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000487 ! simple squamous epithelium [Term] id: UBERON:0004823 name: intrahepatic bile duct epithelium synonym: "epithelial tissue of intrahepatic bile duct" EXACT [] synonym: "epithelium of intrahepatic bile duct" EXACT [] synonym: "intrahepatic bile duct epithelial tissue" EXACT [] is_a: UBERON:0004820 ! bile duct epithelium [Term] id: UBERON:0004852 name: cardiovascular system endothelium synonym: "vascular endothelia" RELATED [] is_a: UBERON:0001986 ! endothelium [Term] id: UBERON:0004877 name: visceral endoderm is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue [Term] id: UBERON:0004880 name: chordamesoderm synonym: "axial chorda mesoderm" EXACT [] synonym: "chorda mesoderm" EXACT [] synonym: "dorsal mesoderm" EXACT [] synonym: "presumptive notochord" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0004905 name: articulation synonym: "joint" NARROW [] is_a: UBERON:0034921 ! multi organ part structure [Term] id: UBERON:0004909 name: epithelium of gonad synonym: "gonad epithelium" EXACT [] synonym: "gonadal epithelium" EXACT [] synonym: "gonadal sheath" RELATED [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0004910 name: epithelium of male gonad synonym: "testis epithelium" EXACT [] synonym: "testis sheath" NARROW [] is_a: UBERON:0004909 ! epithelium of gonad [Term] id: UBERON:0004921 name: subdivision of digestive tract synonym: "alimentary system subdivision" RELATED [] synonym: "intestinal tract" RELATED [] synonym: "segment of intestinal tract" RELATED [] synonym: "subdivision of alimentary system" RELATED [] is_a: UBERON:0013522 ! subdivision of tube [Term] id: UBERON:0004923 name: organ component layer is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0004997 name: mucosa of pyloric antrum synonym: "antral mucosa" EXACT [] synonym: "antrum of stomach mucosa" EXACT [] synonym: "antrum of stomach mucosa of organ" EXACT [] synonym: "antrum of stomach mucous membrane" EXACT [] synonym: "antrum of stomach organ mucosa" EXACT [] synonym: "gastric antrum mucosa" RELATED [] synonym: "mucosa of antrum of stomach" EXACT [] synonym: "mucosa of organ of antrum of stomach" EXACT [] synonym: "mucosa of organ of pyloric antrum" EXACT [] synonym: "mucosa of organ of stomach pyloric antrum" EXACT [] synonym: "mucosa of stomach pyloric antrum" EXACT [] synonym: "mucous membrane of antrum of stomach" EXACT [] synonym: "mucous membrane of pyloric antrum" EXACT [] synonym: "mucous membrane of stomach pyloric antrum" EXACT [] synonym: "organ mucosa of antrum of stomach" EXACT [] synonym: "organ mucosa of pyloric antrum" EXACT [] synonym: "organ mucosa of stomach pyloric antrum" EXACT [] synonym: "pyloric antrum mucosa" EXACT [] synonym: "pyloric antrum mucosa of organ" EXACT [] synonym: "pyloric antrum mucous membrane" EXACT [] synonym: "pyloric antrum organ mucosa" EXACT [] synonym: "stomach pyloric antrum mucosa" EXACT [] synonym: "stomach pyloric antrum mucosa of organ" EXACT [] synonym: "stomach pyloric antrum mucous membrane" EXACT [] synonym: "stomach pyloric antrum organ mucosa" EXACT [] is_a: UBERON:0004998 ! mucosa of pylorus [Term] id: UBERON:0004998 name: mucosa of pylorus synonym: "antropyloric mucosa" RELATED [] synonym: "mucosa of organ of pyloric part of stomach" EXACT [] synonym: "mucosa of organ of pylorus" EXACT [] synonym: "mucosa of organ of stomach pyloric region" EXACT [] synonym: "mucosa of pyloric part of stomach" EXACT [] synonym: "mucosa of stomach pyloric region" EXACT [] synonym: "mucous membrane of pyloric part of stomach" EXACT [] synonym: "mucous membrane of pylorus" EXACT [] synonym: "mucous membrane of stomach pyloric region" EXACT [] synonym: "organ mucosa of pyloric part of stomach" EXACT [] synonym: "organ mucosa of pylorus" EXACT [] synonym: "organ mucosa of stomach pyloric region" EXACT [] synonym: "pyloric part of stomach mucosa" EXACT [] synonym: "pyloric part of stomach mucosa of organ" EXACT [] synonym: "pyloric part of stomach mucous membrane" EXACT [] synonym: "pyloric part of stomach organ mucosa" EXACT [] synonym: "pylorus mucosa" EXACT [] synonym: "pylorus mucosa of organ" EXACT [] synonym: "pylorus mucous membrane" EXACT [] synonym: "pylorus organ mucosa" EXACT [] synonym: "stomach pyloric region mucosa" EXACT [] synonym: "stomach pyloric region mucosa of organ" EXACT [] synonym: "stomach pyloric region mucous membrane" EXACT [] synonym: "stomach pyloric region organ mucosa" EXACT [] is_a: UBERON:0001199 ! mucosa of stomach [Term] id: UBERON:0005057 name: immune organ synonym: "immune system organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0005058 name: hemolymphoid system gland synonym: "haemolymphoid system gland" RELATED [] synonym: "hemopoietic or lymphoid gland" EXACT [] synonym: "hemopoietic or lymphoid organ" BROAD [] is_a: UBERON:0002530 ! gland [Term] id: UBERON:0005090 name: muscle structure synonym: "muscle" RELATED [] synonym: "muscle element" RELATED [] synonym: "musculus" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0005096 name: descending thin limb synonym: "descending limb of henle%27s loop" RELATED [] synonym: "descending limb of loop of henle" RELATED [] synonym: "descending thin limb of loop of Henle" EXACT [] synonym: "loop of Henle descending thin limb" EXACT [] synonym: "loop of henle thin descending limb" EXACT [] synonym: "pars descendens (tubulus attenuatus)" EXACT [] synonym: "thin descending limb" EXACT [] synonym: "thin descending limb of loop of henle" RELATED [] synonym: "thin descending limb of the loop of henle" RELATED [] synonym: "thin descending loop of henle" RELATED [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0005097 name: renal connecting tubule synonym: "connecting tubule" EXACT [] synonym: "kidney connecting tubule" EXACT [] synonym: "tubulus renalis arcuatus" RELATED [] is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0005103 name: mesonephric epithelium is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0005106 name: metanephric tubule is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005108 ! metanephric epithelium is_a: UBERON:0006555 ! excretory tube [Term] id: UBERON:0005108 name: metanephric epithelium is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0005134 name: metanephric nephron epithelium is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0005108 ! metanephric epithelium [Term] id: UBERON:0005146 name: metanephric nephron tubule is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0005106 ! metanephric tubule is_a: UBERON:0005134 ! metanephric nephron epithelium [Term] id: UBERON:0005156 name: reproductive structure synonym: "reproductive system element" EXACT [] synonym: "reproductive system structure" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0005162 name: multi cell part structure synonym: "cell part cluster" RELATED [] synonym: "multi-cell-component structure" EXACT [] synonym: "multi-cell-part structure" EXACT [] is_a: UBERON:0000477 ! anatomical cluster [Term] id: UBERON:0005164 name: ascending limb of loop of Henle synonym: "ascending limb" BROAD [] synonym: "ascending limb of Henle's loop" EXACT [] synonym: "distal straight tubule" RELATED [] synonym: "loop of Henle ascending limb" EXACT [] is_a: UBERON:0004135 ! distal tubule [Term] id: UBERON:0005167 name: papillary duct synonym: "Bellini's duct" RELATED [] synonym: "duct of Bellini" RELATED [] synonym: "papillary duct" EXACT [] synonym: "papillary duct of kidney" EXACT [] synonym: "renal papillary duct" EXACT [] is_a: UBERON:0001232 ! collecting duct of renal tubule [Term] id: UBERON:0005168 name: renal interlobular vein synonym: "interlobular vein" EXACT [] synonym: "interlobular veins of kidney" RELATED [] synonym: "set of interlobular veins of kidney" RELATED [] synonym: "venae interlobulares renis" EXACT [] synonym: "venae interlobulares renis" RELATED [] is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel [Term] id: UBERON:0005169 name: interstitial tissue synonym: "interstitium" EXACT [] is_a: UBERON:0003891 ! stroma [Term] id: UBERON:0005172 name: abdomen element synonym: "abdomen organ" EXACT [] is_a: UBERON:0005173 ! abdominal segment element [Term] id: UBERON:0005173 name: abdominal segment element synonym: "abdominal segment organ" EXACT [] is_a: UBERON:0005177 ! trunk region element [Term] id: UBERON:0005174 name: dorsal region element synonym: "back organ" EXACT [] synonym: "dorsal region organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0005176 name: tooth enamel organ synonym: "dental organ" EXACT [] synonym: "enamel organ" EXACT [] synonym: "odontogenic organ" RELATED [] synonym: "organum enameleum" RELATED [] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0005177 name: trunk region element synonym: "trunk organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0005178 name: thoracic cavity element synonym: "thoracic cavity organ" EXACT [] is_a: UBERON:0005181 ! thoracic segment organ [Term] id: UBERON:0005179 name: pelvic region element synonym: "pelvic element" EXACT [] synonym: "pelvis organ" EXACT [] synonym: "pelvis region organ" EXACT [] is_a: UBERON:0005173 ! abdominal segment element [Term] id: UBERON:0005181 name: thoracic segment organ synonym: "upper body organ" RELATED [] is_a: UBERON:0005177 ! trunk region element [Term] id: UBERON:0005185 name: renal medulla collecting duct synonym: "kidney medulla collecting duct" EXACT [] synonym: "medullary collecting duct" EXACT [] is_a: UBERON:0013522 ! subdivision of tube [Term] id: UBERON:0005211 name: renal medulla interstitium synonym: "kidney medulla interstitium" EXACT [] synonym: "medullary interstitium" NARROW [] synonym: "medullary stroma" RELATED [] synonym: "renal medullary interstitial tissue" EXACT [] synonym: "renal medullary interstitium" EXACT [] is_a: UBERON:0005215 ! kidney interstitium [Term] id: UBERON:0005212 name: Leydig cell region of testis synonym: "interstitium of testis" EXACT [] synonym: "interstitium of the testis" EXACT [] synonym: "testis - interstitial" EXACT [] synonym: "testis interstitial tissue" EXACT [] synonym: "testis interstitium" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005169 ! interstitial tissue [Term] id: UBERON:0005213 name: outer renal medulla interstitium synonym: "kidney outer medulla interstitium" EXACT [] synonym: "outer medullary interstitium" EXACT [] is_a: UBERON:0005211 ! renal medulla interstitium [Term] id: UBERON:0005214 name: inner renal medulla interstitium synonym: "inner medullary interstitium" EXACT [] synonym: "kidney inner medulla interstitium" EXACT [] synonym: "papillary interstitium" RELATED [] is_a: UBERON:0005211 ! renal medulla interstitium [Term] id: UBERON:0005215 name: kidney interstitium synonym: "interstitial tissue of kidney" EXACT [] synonym: "kidney interstitium group" RELATED [] synonym: "renal interstitial tissue" EXACT [] synonym: "renal interstitium" EXACT [] synonym: "renal stroma" EXACT [] synonym: "stroma of kidney" EXACT [] is_a: UBERON:0005169 ! interstitial tissue [Term] id: UBERON:0005253 name: head mesenchyme synonym: "cephalic mesenchyme" EXACT [] synonym: "cranial mesenchyme" RELATED [] synonym: "desmocranium" RELATED [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue [Term] id: UBERON:0005254 name: upper leg mesenchyme is_a: UBERON:0003860 ! hindlimb mesenchyme [Term] id: UBERON:0005256 name: trunk mesenchyme synonym: "trunk and cervical mesenchyme" RELATED [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue [Term] id: UBERON:0005268 name: renal cortex artery synonym: "kidney cortex artery" EXACT [] synonym: "renal cortex arterial system" RELATED [] synonym: "renal cortex artery" EXACT [] is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel [Term] id: UBERON:0005269 name: renal cortex vein synonym: "kidney cortex vein" RELATED [] synonym: "renal cortex venous system" RELATED [] is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel [Term] id: UBERON:0005270 name: renal cortex interstitium synonym: "cortical stroma" RELATED [] synonym: "kidney cortex interstitium" EXACT [] synonym: "renal cortical interstitial tissue" EXACT [] is_a: UBERON:0005215 ! kidney interstitium [Term] id: UBERON:0005271 name: juxtamedullary cortex synonym: "inner cortex of kidney" EXACT [] synonym: "inner renal cortex" EXACT [] synonym: "juxtamedullary cortex of kidney" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0005272 name: peritubular capillary is_a: UBERON:0003527 ! kidney capillary [Term] id: UBERON:0005291 name: embryonic tissue synonym: "developing tissue" RELATED [] synonym: "portion of embryonic tissue" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0002050 ! embryonic structure [Term] id: UBERON:0005292 name: extraembryonic tissue synonym: "extra-embryonic tissue" EXACT [] is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0005310 name: pronephric nephron tubule synonym: "pronephric tubule" EXACT [] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0012275 ! meso-epithelium [Term] id: UBERON:0005317 name: pulmonary artery endothelium synonym: "pulmonary artery endothelial tube" EXACT [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0005329 name: mesonephric nephron tubule synonym: "mesonephric renal tubule" EXACT [] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium [Term] id: UBERON:0005330 name: mesonephric nephron epithelium is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0005103 ! mesonephric epithelium [Term] id: UBERON:0005358 name: ventricle of nervous system synonym: "region of wall of ventricular system of neuraxis" RELATED [] synonym: "ventricular layer" EXACT [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0005375 name: spinal cord ventral column synonym: "anterior column" EXACT [] synonym: "spinal cord anterior column" EXACT [] synonym: "ventral column" EXACT [] is_a: UBERON:0016550 ! spinal cord column [Term] id: UBERON:0005376 name: olfactory bulb external plexiform layer synonym: "EPL" RELATED [] synonym: "external plexiform layer" BROAD [] synonym: "external plexiform layer of the olfactory bulb" RELATED [] synonym: "OB outer plexiform layer" RELATED [] synonym: "olfactory bulb main external plexiform layer" EXACT [] is_a: UBERON:0009950 ! olfactory bulb plexiform layer [Term] id: UBERON:0005377 name: olfactory bulb glomerular layer synonym: "glomerular layer" BROAD [] synonym: "glomerular layer of the olfactory bulb" RELATED [] synonym: "olfactory bulb main glomerulus" EXACT [] synonym: "stratum glomerulosum bulbi olfactorii" EXACT [] is_a: UBERON:0004001 ! olfactory bulb layer [Term] id: UBERON:0005384 name: nasal cavity epithelium synonym: "nasal epithelium" EXACT [] synonym: "nasal mucosa" RELATED [] is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004814 ! upper respiratory tract epithelium is_a: UBERON:0019306 ! nose epithelium [Term] id: UBERON:0005385 name: nasal cavity respiratory epithelium is_a: UBERON:0005384 ! nasal cavity epithelium is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium [Term] id: UBERON:0005388 name: photoreceptor array synonym: "light-sensitive tissue" EXACT [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0005389 name: transparent eye structure synonym: "lens" NARROW [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0005396 name: carotid artery segment synonym: "carotid" EXACT [] synonym: "carotid artery" EXACT [] synonym: "common carotid arterial subdivision" RELATED [] synonym: "subdivision of common carotid artery" EXACT [] is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0005398 name: female reproductive gland is_a: UBERON:0003937 ! sex gland [Term] id: UBERON:0005399 name: male reproductive gland synonym: "accessory sex gland" RELATED [] is_a: UBERON:0003937 ! sex gland [Term] id: UBERON:0005406 name: perirenal fat synonym: "adipose capsule of kidney" RELATED [] synonym: "capsula adiposa renis" RELATED [] synonym: "fatty capsule of kidney" RELATED [] synonym: "perinephric fat" RELATED [] synonym: "periphrenic fascia" RELATED [] synonym: "perirenal fascia" EXACT [] synonym: "perirenal fascia" RELATED [] synonym: "perirenal fat capsule" RELATED [] synonym: "perirenal fat pad" RELATED [] is_a: UBERON:0001013 ! adipose tissue [Term] id: UBERON:0005408 name: circumventricular organ synonym: "circumventricular organ" EXACT [] synonym: "circumventricular organ of neuraxis" EXACT [] synonym: "CVO" EXACT [] is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0005423 name: developing anatomical structure synonym: "developing structure" RELATED [] synonym: "developmental structure" RELATED [] synonym: "developmental tissue" RELATED [] is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0005629 name: vascular plexus synonym: "plexus vasculosus" EXACT [] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0005631 name: extraembryonic membrane is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0000478 ! extraembryonic structure [Term] id: UBERON:0005636 name: caecum epithelium is_a: UBERON:0000397 ! colonic epithelium [Term] id: UBERON:0005725 name: olfactory system is_a: UBERON:0005726 ! chemosensory system [Term] id: UBERON:0005726 name: chemosensory system is_a: UBERON:0001032 ! sensory system [Term] id: UBERON:0005734 name: tunica adventitia of blood vessel synonym: "adventitia externa" EXACT [] synonym: "external coat" RELATED [] synonym: "tunica adventitia" EXACT [] synonym: "tunica adventitia of vessel" EXACT [] synonym: "tunica adventitia vasorum" RELATED [] synonym: "tunica externa vasorum" RELATED [] is_a: UBERON:0004797 ! blood vessel layer is_a: UBERON:0005742 ! adventitia [Term] id: UBERON:0005742 name: adventitia synonym: "tunica advetitia" NARROW [] synonym: "tunica externa" NARROW [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0005750 name: glomerular parietal epithelium synonym: "Bowman's parietal epithelium" EXACT [] synonym: "capsular epithelium" EXACT [] synonym: "glomerular capsule parietal layer" EXACT [] synonym: "kidney parietal epithelium" RELATED [] synonym: "outer layer of glomerular capsule" EXACT [] synonym: "parietal capsular epithelium" EXACT [] synonym: "parietal epithelial layer" EXACT [] synonym: "parietal epithelium of Bowman's capsule" EXACT [] synonym: "parietal layer of Bowman capsule" EXACT [] synonym: "parietal layer of Bowman's capsule" EXACT [] synonym: "parietal layer of glomerular capsule" EXACT [] synonym: "renal glomerular capsule epithelium" EXACT [] is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0004188 ! glomerular epithelium [Term] id: UBERON:0005751 name: visceral layer of glomerular capsule synonym: "Bowman's visceral epithelium" EXACT [] synonym: "glomerular capsule visceral layer" EXACT [] synonym: "inner epithelial layer of Bowman's capsule" EXACT [] synonym: "podocyte layer of Bowman's capsule" EXACT [] synonym: "visceral epithelium of Bowman's capsule" EXACT [] synonym: "visceral layer of Bowman's capsule" EXACT [] synonym: "visceral layer of glomerular capsule" EXACT [] is_a: UBERON:0004211 ! nephron epithelium [Term] id: UBERON:0005800 name: section of aorta synonym: "aortic section" EXACT [] synonym: "aortic segment" RELATED [] synonym: "portion of aorta" RELATED [] synonym: "segment of aorta" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube [Term] id: UBERON:0005856 name: developing mesenchymal condensation synonym: "mesenchyme condensation" EXACT [] is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0011585 ! cell condensation [Term] id: UBERON:0005863 name: cartilaginous condensation synonym: "cartilage condensation" EXACT [] synonym: "cartilagenous condensation" EXACT [] synonym: "chondrogenic condensation" EXACT [] is_a: UBERON:0005856 ! developing mesenchymal condensation [Term] id: UBERON:0005866 name: pre-cartilage condensation synonym: "pre-chondrogenic condensation" EXACT [] synonym: "precartilage condensation" EXACT [] synonym: "precartilagenous condensation" EXACT [] synonym: "prechondrogenic condensation" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0006598 ! presumptive structure [Term] id: UBERON:0005893 name: leg bone is_a: UBERON:0003464 ! hindlimb bone [Term] id: UBERON:0005904 name: duct of male reproductive system is_a: UBERON:0000058 ! duct is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0005910 name: transitional epithelium synonym: "epithelium transitionale" EXACT [] synonym: "urothelium" NARROW [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium [Term] id: UBERON:0005911 name: endo-epithelium synonym: "endoderm-derived epithelium" EXACT [] synonym: "endoepithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0005933 name: hair root sheath is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0005941 name: hair inner root sheath synonym: "hair follicle inner root sheath" EXACT [] synonym: "inner root sheath" RELATED [] synonym: "inner root sheath of hair follicle" EXACT [] synonym: "inner sheath of hair follicle" EXACT [] synonym: "internal root sheath of hair follicle" EXACT [] is_a: UBERON:0005933 ! hair root sheath [Term] id: UBERON:0005942 name: hair outer root sheath synonym: "external root sheath of hair follicle" EXACT [] synonym: "hair follicle outer root sheath" EXACT [] synonym: "ORS" RELATED [] synonym: "outer hair sheath" RELATED [] synonym: "outer root sheath" RELATED [] synonym: "outer root sheath of hair follicle" EXACT [] is_a: UBERON:0005933 ! hair root sheath [Term] id: UBERON:0005969 name: eye trabecular meshwork synonym: "cribiform ligament" RELATED [] synonym: "eye trabecular meshwork" EXACT [] synonym: "Hueck's ligament" RELATED [] synonym: "iridis" RELATED [] synonym: "ligamentum peactin-tum iridis" RELATED [] synonym: "ligamentum pectinatum" RELATED [] synonym: "ligamentum pectinatum anguli iridocornealis" RELATED [] synonym: "ligamentum pectinatum iridis" RELATED [] synonym: "pectinate ligament" RELATED [] synonym: "pectinate ligament of iris" RELATED [] synonym: "reticulum trabeculare" EXACT [] synonym: "reticulum trabeculare sclerae" RELATED [] synonym: "scleral trabeculae" RELATED [] synonym: "scleral trabecular" RELATED [] synonym: "scleral trabecule" RELATED [] synonym: "scribiform ligament" RELATED [] synonym: "trabecular mesh" RELATED [] synonym: "trabecular meshwork" RELATED [] synonym: "trabecular meshwork of the eye" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0005983 name: heart layer is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0005985 name: coronary vessel is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0005986 name: left branch of atrioventricular bundle synonym: "crus sinistrum (fasciculi atrioventricularis)" EXACT [] synonym: "left bundle branch" EXACT [] synonym: "left bundle branch of bundle of His" EXACT [] synonym: "left bundle of atrioventricular bundle" EXACT [] synonym: "left crus of atrioventricular bundle" EXACT [] synonym: "left posterior branch" EXACT [] synonym: "left posterior bundle" EXACT [] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle [Term] id: UBERON:0005987 name: right branch of atrioventricular bundle synonym: "crus dextrum (fasciculi atrioventricularis)" EXACT [] synonym: "right bundle" EXACT [] synonym: "right bundle branch" EXACT [] synonym: "right bundle branch of bundle of His" EXACT [] synonym: "right right crus of atrioventricular bundle" EXACT [] synonym: "right ventricular bundle" EXACT [] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle [Term] id: UBERON:0006003 name: integumentary adnexa synonym: "adnexae cutis" RELATED [] synonym: "body hair or bristle" NARROW [] synonym: "skin adnexa" RELATED [] synonym: "skin adnexal structure" RELATED [] synonym: "skin appendage" RELATED [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0006004 name: hair follicle matrix region synonym: "germinal matrix of hair bulb" EXACT [] synonym: "lower part of bulb of hair follicle" EXACT [] synonym: "lower zone of bulb of hair follicle" EXACT [] is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0006058 name: multi-limb segment region is_a: UBERON:0010758 ! subdivision of organism along appendicular axis [Term] id: UBERON:0006234 name: femur pre-cartilage condensation synonym: "femoral pre-cartilage condensation" RELATED [] is_a: UBERON:0005254 ! upper leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010882 ! limb bone pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015052 ! femur endochondral element is_a: UBERON:0017650 ! developing mesenchymal structure [Term] id: UBERON:0006311 name: chamber of eyeball synonym: "chamber of eye" RELATED [] synonym: "eye chamber" EXACT [] synonym: "eyeball chamber" EXACT [] is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0006314 name: bodily fluid synonym: "body fluid" EXACT [] synonym: "fluid" BROAD [] is_a: UBERON:0000463 ! organism substance [Term] id: UBERON:0006331 name: brainstem nucleus synonym: "brain stem nucleus" RELATED [] is_a: UBERON:0002308 ! nucleus of brain [Term] id: UBERON:0006334 name: posterior lateral line synonym: "pll" EXACT [] is_a: UBERON:0010202 ! lateral line [Term] id: UBERON:0006341 name: outer renal medulla peritubular capillary synonym: "kidney outer medulla peritubular capillary" EXACT [] is_a: UBERON:0005272 ! peritubular capillary [Term] id: UBERON:0006376 name: premacula segment of distal straight tubule synonym: "distal straight tubule premacula segment" EXACT [] synonym: "kidney medulla loop of Henle ascending limb thick segment" EXACT [] synonym: "medullary thick ascending limb of Henle's loop" EXACT [] synonym: "renal medulla loop of Henle ascending limb thick segment" EXACT [] synonym: "renal medulla thick ascending limb" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0008408 ! distal tubular epithelium [Term] id: UBERON:0006444 name: annulus fibrosus synonym: "anulus" BROAD [] synonym: "anulus fibrosus" EXACT [] synonym: "fibrocartilaginous ring" EXACT [] synonym: "fibrous ring" RELATED [] is_a: UBERON:0001995 ! fibrocartilage [Term] id: UBERON:0006534 name: renal convoluted tubule synonym: "convoluted tubule" EXACT [] synonym: "kidney convoluted tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0006555 name: excretory tube is_a: UBERON:0000025 ! tube [Term] id: UBERON:0006568 name: hypothalamic nucleus synonym: "nucleus of hypothalamus" EXACT [] is_a: UBERON:0006569 ! diencephalic nucleus [Term] id: UBERON:0006569 name: diencephalic nucleus is_a: UBERON:0002308 ! nucleus of brain [Term] id: UBERON:0006598 name: presumptive structure synonym: "future structure" EXACT [] synonym: "presumptive structures" EXACT [] is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0006615 name: venous sinus synonym: "blood sinus" RELATED [] is_a: UBERON:0003920 ! venous blood vessel [Term] id: UBERON:0006660 name: muscular coat synonym: "muscular coat" RELATED [] synonym: "muscular layer" EXACT [] synonym: "muscularis" RELATED [] synonym: "muscularis externa" RELATED [] synonym: "muscularis layer" EXACT [] synonym: "muscularis propria" RELATED [] synonym: "transverse muscular fibers" RELATED [] synonym: "tunica externa" RELATED [] synonym: "tunica muscularis" EXACT [] synonym: "tunica muscularis" RELATED [] is_a: UBERON:0018260 ! layer of muscle tissue [Term] id: UBERON:0006725 name: spiral ligament synonym: "ligamentum spirale ductus cochlearis" EXACT [] synonym: "spiral cochlear ligament" EXACT [] synonym: "spiral ligament of cochlea" EXACT [] synonym: "spiral ligament of cochlear duct" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0008845 ! nonskeletal ligament is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0006799 name: glandular epithelium is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0006815 name: areolar connective tissue synonym: "areolar tissue" RELATED [] synonym: "loose areolar connective tissue" EXACT [] synonym: "loose connective tissue" RELATED [] is_a: UBERON:0011825 ! loose connective tissue [Term] id: UBERON:0006851 name: renal cortex peritubular capillary synonym: "kidney cortex peritubular capillary" EXACT [] is_a: UBERON:0005272 ! peritubular capillary [Term] id: UBERON:0006853 name: renal cortex tubule synonym: "cortical tubule" RELATED [] synonym: "kidney cortex tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0006854 name: distal straight tubule postmacula segment synonym: "cortical thick ascending limb of Henle's loop" EXACT [] synonym: "kidney cortex loop of Henle ascending limb thick segment" EXACT [] synonym: "renal cortex loop of Henle ascending limb thick segment" EXACT [] synonym: "renal cortex thick ascending limb" EXACT [] is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0008408 ! distal tubular epithelium [Term] id: UBERON:0006855 name: muscular coat of ureter synonym: "muscular coat of ureter" EXACT [] synonym: "muscular layer of ureter" EXACT [] synonym: "muscularis of ureter" EXACT [] synonym: "tunica muscularis (ureter)" EXACT [] synonym: "tunica muscularis ureteris" EXACT [] synonym: "ureteral smooth muscle layer" RELATED [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006660 ! muscular coat [Term] id: UBERON:0006858 name: adrenal/interrenal gland synonym: "adrenal - interrenal gland" RELATED [] synonym: "adrenal gland - interrenal gland" EXACT [] synonym: "adrenal gland/interrenal tissue" EXACT [] synonym: "suprarenal gland - interrenal gland" RELATED [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0006868 name: seminal fluid secreting gland is_a: UBERON:0005399 ! male reproductive gland [Term] id: UBERON:0006876 name: vasculature of organ synonym: "organ vasculature" EXACT [] synonym: "set of blood vessels of organ" EXACT [] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0006914 name: squamous epithelium is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0006915 name: stratified squamous epithelium synonym: "epithelium stratificatum squamosum" EXACT [] is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium [Term] id: UBERON:0006925 name: digestive gland synonym: "digestive system gland" EXACT [] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0006932 name: vestibular epithelium synonym: "epithelium of vestibular labyrinth" EXACT [] synonym: "inner ear vestibular component epithelium" EXACT [] synonym: "vestibular sensory epithelium" EXACT [] is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0006937 ! inner ear epithelium [Term] id: UBERON:0006934 name: sensory epithelium synonym: "neuroepithelium" RELATED [] is_a: UBERON:0000488 ! atypical epithelium [Term] id: UBERON:0006935 name: crista ampullaris neuroepithelium synonym: "ampullary crest neuroepithelium" RELATED [] synonym: "epithelium of crista of ampulla of semicircular duct of membranous labyrinth" EXACT [] is_a: UBERON:0006932 ! vestibular epithelium [Term] id: UBERON:0006937 name: inner ear epithelium is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0015807 ! ear epithelium [Term] id: UBERON:0006955 name: uterine epithelium synonym: "uterus epithelium" RELATED [] is_a: UBERON:0004804 ! oviduct epithelium [Term] id: UBERON:0006964 name: pars distalis of adenohypophysis synonym: "anterior lobe" RELATED [] synonym: "DHP" BROAD [] synonym: "distal part of hypophysis" EXACT [] synonym: "distal part of the hypophysis" RELATED [] synonym: "pars anterior" BROAD [] synonym: "pars anterior of adenohypophysis" EXACT [] synonym: "pars distalis" RELATED [] synonym: "pars distalis (glandula pituitaria)" EXACT [] synonym: "pars distalis (hypophysis)" RELATED [] synonym: "pars distalis adenohypophyseos" RELATED [] synonym: "pars distalis adenohypophysis" EXACT [] synonym: "pars distalis lobi anterioris hypophyseos" RELATED [] synonym: "pars distalis of anterior lobe of pituitary gland" EXACT [] synonym: "pars glandularis" RELATED [] synonym: "pars glandularis of adenohypophysis" EXACT [] is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0007100 name: primary circulatory organ synonym: "adult heart" RELATED [] synonym: "dorsal tube" NARROW [] synonym: "heart" NARROW [] is_a: UBERON:0015228 ! circulatory organ [Term] id: UBERON:0007196 name: tracheobronchial tree synonym: "tracheobronchial system" RELATED [] is_a: UBERON:0000062 ! organ is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0007213 name: mesenchyme derived from head neural crest synonym: "head mesenchyme from cranial neural crest" EXACT [] synonym: "head mesenchyme from neural crest" EXACT [] synonym: "head neural crest derived mesenchyme" EXACT [] is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest [Term] id: UBERON:0007329 name: pancreatic duct synonym: "duct of pancreas" EXACT [] synonym: "ductus pancreaticus" RELATED [] synonym: "pancreas duct" EXACT [] is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure [Term] id: UBERON:0007376 name: outer epithelium synonym: "epidermis" EXACT [] synonym: "epidermis (sensu Metazoa)" EXACT [] synonym: "hypoderm" RELATED [] synonym: "hypodermis" RELATED [] synonym: "outer epidermal layer" EXACT [] synonym: "outer epithelial layer" EXACT [] is_a: UBERON:0003102 ! surface structure is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0007475 name: matrix-based tissue is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0007521 name: smooth muscle sphincter is_a: UBERON:0004590 ! sphincter muscle [Term] id: UBERON:0007524 name: dense mesenchyme tissue is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0007592 name: ciliated columnar epithelium is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0007601 ! ciliated epithelium [Term] id: UBERON:0007601 name: ciliated epithelium is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0007616 name: layer of synovial tissue synonym: "stratum synoviale" NARROW [] synonym: "synovial layer" NARROW [] synonym: "synovial membrane" NARROW [] synonym: "synovial tissue" RELATED [] synonym: "synovium" EXACT [] is_a: UBERON:0000042 ! serous membrane [Term] id: UBERON:0007625 name: pigment epithelium of eye synonym: "eye pigment epithelium" RELATED [] is_a: UBERON:0019304 ! sensory organ epithelium [Term] id: UBERON:0007635 name: nucleus of medulla oblongata is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus [Term] id: UBERON:0007685 name: region of nephron tubule synonym: "region of renal tubule" RELATED [] synonym: "renal tubule region" EXACT [] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0004810 ! nephron tubule epithelium [Term] id: UBERON:0007771 name: epidermis gland synonym: "epidermal gland" EXACT [] synonym: "gland of epidermis" EXACT [] is_a: UBERON:0002419 ! skin gland [Term] id: UBERON:0007844 name: cartilage element synonym: "cartilage" RELATED [] synonym: "cartilage organ" EXACT [] synonym: "cartilaginous element" EXACT [] synonym: "chondrogenic element" EXACT [] is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0007845 name: regular connective tissue is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0007846 name: dense regular connective tissue synonym: "dense fibrous connective tissue" EXACT [] synonym: "dense regular collagenous connective tissue" EXACT [] synonym: "dense regular collagenous tissue" EXACT [] synonym: "regular dense connective tissue" EXACT [] synonym: "typus regularis (textus connectivus collagenosus compactus)" EXACT [] is_a: UBERON:0007845 ! regular connective tissue is_a: UBERON:0011823 ! dense connective tissue [Term] id: UBERON:0008001 name: irregular bone synonym: "os irregulare" EXACT [] synonym: "os irregulare" RELATED [] is_a: UBERON:0001474 ! bone element [Term] id: UBERON:0008202 name: bone of hip region is_a: UBERON:0001474 ! bone element [Term] id: UBERON:0008266 name: periodontal ligament synonym: "alveolar periosteum" RELATED [] synonym: "alveolodental ligament" RELATED [] synonym: "alveolodental membrane" RELATED [] synonym: "desmodontium" RELATED [] synonym: "fibra periodontalis" EXACT [] synonym: "odontoperiosteum" RELATED [] synonym: "paradentium" RELATED [] synonym: "PDL" RELATED [] synonym: "peridental membrane" RELATED [] synonym: "peridontal fiber" RELATED [] synonym: "peridontal fibre" RELATED [] synonym: "peridontal ligament" RELATED [] synonym: "peridontal ligament fiber" RELATED [] synonym: "peridontal ligament fibre" RELATED [] synonym: "peridontal membrane" RELATED [] synonym: "peridontium" RELATED [] synonym: "periodontal fiber" EXACT [] synonym: "periodontal fibre" EXACT [] is_a: UBERON:0008846 ! skeletal ligament is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0008307 name: heart endothelium synonym: "cardiac endothelium" RELATED [] is_a: UBERON:0004852 ! cardiovascular system endothelium [Term] id: UBERON:0008339 name: microvascular endothelium is_a: UBERON:0004852 ! cardiovascular system endothelium [Term] id: UBERON:0008346 name: duodenal epithelium synonym: "epithelium of duodenum" EXACT [] is_a: UBERON:0013636 ! epithelium of intestinal villus [Term] id: UBERON:0008404 name: proximale tubular epithelium synonym: "proximale tubule epithelium" RELATED [] is_a: UBERON:0004810 ! nephron tubule epithelium [Term] id: UBERON:0008408 name: distal tubular epithelium synonym: "distal tubule epithelium" RELATED [] is_a: UBERON:0004810 ! nephron tubule epithelium [Term] id: UBERON:0008784 name: lower limb segment synonym: "free lower limb segment" EXACT [] synonym: "free lower limb subdivision" EXACT [] synonym: "segment of free lower limb" EXACT [] synonym: "subdivision of free lower limb" EXACT [] is_a: UBERON:0002529 ! limb segment [Term] id: UBERON:0008785 name: upper limb segment synonym: "free upper limb segment" EXACT [] synonym: "free upper limb subdivision" EXACT [] synonym: "segment of free upper limb" EXACT [] synonym: "subdivision of free upper limb" EXACT [] is_a: UBERON:0002529 ! limb segment [Term] id: UBERON:0008845 name: nonskeletal ligament synonym: "fibrous ligament" RELATED [] synonym: "non-skeletal ligament" EXACT [] is_a: UBERON:0000211 ! ligament [Term] id: UBERON:0008846 name: skeletal ligament synonym: "articular larua" EXACT [] synonym: "articular ligament" EXACT [] synonym: "ligament" BROAD [] synonym: "true ligament" EXACT [] is_a: UBERON:0000211 ! ligament [Term] id: UBERON:0008859 name: cardiac gastric gland synonym: "cardiac gland" RELATED [] synonym: "gardiac gland" EXACT [] synonym: "gastric cardiac gland" EXACT [] synonym: "gastric cardiac mucuous gland" EXACT [] synonym: "gastric gland of cardia" EXACT [] synonym: "glandula cardiaca (gaster)" EXACT [] is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland [Term] id: UBERON:0008861 name: pyloric gastric gland synonym: "glandula pylorica" EXACT [] synonym: "pyloric antrum gland" EXACT [] synonym: "pyloric gland" EXACT [] synonym: "pyloric mucuous gland" EXACT [] is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland [Term] id: UBERON:0008883 name: osteoid synonym: "osteoid tissue" EXACT [] synonym: "pre-bone" EXACT [] synonym: "prebone" EXACT [] synonym: "prebone tissue" EXACT [] is_a: UBERON:0002481 ! bone tissue is_a: UBERON:0007475 ! matrix-based tissue [Term] id: UBERON:0008904 name: neuromast synonym: "cyatocïde@fr" EXACT [] synonym: "lateral line neuromast" EXACT [] synonym: "lateral line organ" BROAD [] synonym: "neuromast organ" EXACT [] synonym: "neuromaste superficiel@fr" EXACT [] synonym: "neuromasts" EXACT [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0035555 ! lateral line sense organ [Term] id: UBERON:0008906 name: lateral line nerve synonym: "lateral line nerves" EXACT [] is_a: UBERON:0001785 ! cranial nerve [Term] id: UBERON:0009034 name: stomach region is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0009035 name: renal straight tubule synonym: "kidney straight tubule" EXACT [] synonym: "straight tubule" EXACT [] is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0009089 name: inner medulla vasa recta descending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009090 name: outer medulla vasa recta descending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009091 name: vasa recta ascending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009092 name: inner medulla vasa recta ascending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009093 name: outer medulla vasa recta ascending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009095 name: tip of renal papilla synonym: "papillary tip" EXACT [] synonym: "papillary tips" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009202 name: vasa recta descending limb is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009569 name: subdivision of trunk synonym: "region of trunk" EXACT [] synonym: "trunk subdivision" EXACT [] is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0009661 name: midbrain nucleus is_a: UBERON:0002308 ! nucleus of brain [Term] id: UBERON:0009662 name: hindbrain nucleus is_a: UBERON:0002308 ! nucleus of brain [Term] id: UBERON:0009697 name: epithelium of appendix synonym: "appendix epithelium" EXACT [] synonym: "epithelium of vermiform appendix" EXACT [] is_a: UBERON:0005636 ! caecum epithelium [Term] id: UBERON:0009749 name: limb mesenchyme synonym: "limb mesoderm" RELATED [] is_a: UBERON:0003104 ! mesenchyme [Term] id: UBERON:0009751 name: cardiac mesenchyme synonym: "heart mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0009753 name: adrenal gland cortex zone synonym: "adrenal cortical region" EXACT [] synonym: "region of adrenal cortex" RELATED [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0009773 name: renal tubule synonym: "renal tubule (generic)" EXACT [] synonym: "tubule of excretory system" EXACT [] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0006555 ! excretory tube [Term] id: UBERON:0009842 name: glandular acinus synonym: "acini" RELATED [] synonym: "acinus" BROAD [] is_a: UBERON:0034922 ! cell cluster [Term] id: UBERON:0009854 name: digestive tract diverticulum synonym: "diverticulum of gut" RELATED [] synonym: "intestinal pouch" RELATED [] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0009856 ! sac [Term] id: UBERON:0009856 name: sac synonym: "diverticulum" RELATED [] synonym: "pouch" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0009859 name: endosteum is_a: UBERON:0000158 ! membranous layer [Term] id: UBERON:0009870 name: zone of stomach synonym: "gastric zone" EXACT [] synonym: "region of stomach" EXACT [] synonym: "section of stomach" EXACT [] is_a: UBERON:0009034 ! stomach region is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0009882 name: anal column synonym: "column of Morgagni" EXACT [] synonym: "columnae anales" RELATED [] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0009911 name: lobule is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0009918 name: retrotrapezoid nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata [Term] id: UBERON:0009919 name: ureter smooth muscle synonym: "ureteral smooth muscle" EXACT [] synonym: "ureteral smooth muscle layer" EXACT [] is_a: UBERON:0001135 ! smooth muscle tissue [Term] id: UBERON:0009950 name: olfactory bulb plexiform layer synonym: "plexiform layer" BROAD [] is_a: UBERON:0004001 ! olfactory bulb layer [Term] id: UBERON:0009966 name: internodal tract synonym: "interatrial conduction tract" EXACT [] synonym: "internodal conduction tract" EXACT [] synonym: "internodal fasciculus" EXACT [] synonym: "internodal tract muscle tissue" EXACT [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart [Term] id: UBERON:0009967 name: spleen venous sinus synonym: "sinus lienalis" EXACT [] synonym: "sinus splenicus" EXACT [] synonym: "splenic sinus" EXACT [] synonym: "venous sinus of red pulp of spleen" EXACT [] is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0006615 ! venous sinus [Term] id: UBERON:0009969 name: stato-acoustic epithelium is_a: UBERON:0006934 ! sensory epithelium [Term] id: UBERON:0009970 name: epithelium of pancreatic duct synonym: "pancreatic duct epithelium" EXACT [] synonym: "pancreatic ductal epithelium" EXACT [] is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0013697 ! exocrine pancreas epithelium is_a: UBERON:0034969 ! epithelial layer of duct [Term] id: UBERON:0009971 name: principal gastric gland synonym: "acid gland" EXACT [] synonym: "gastric follicle" RELATED [] synonym: "gastric gland" BROAD [] synonym: "glandula gastrica propria" EXACT [] synonym: "main gastric gland" EXACT [] synonym: "oxyntic gland" EXACT [] synonym: "principal gland of fundus of stomach" EXACT [] synonym: "Wassman gland" RELATED [] is_a: UBERON:0000325 ! gastric gland [Term] id: UBERON:0010000 name: multicellular anatomical structure synonym: "multicellular structure" EXACT [] is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0010001 name: cell cluster organ is_a: UBERON:0000062 ! organ is_a: UBERON:0034922 ! cell cluster [Term] id: UBERON:0010039 name: food storage organ is_a: UBERON:0013765 ! digestive system element [Term] id: UBERON:0010047 name: oral gland synonym: "buccal gland" NARROW [] synonym: "gland of oral opening" RELATED [] synonym: "gland of oral region" RELATED [] synonym: "mouth gland" RELATED [] synonym: "oral cavity gland" RELATED [] synonym: "oral region gland" RELATED [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003408 ! gland of gut is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0010077 name: cuboidal epithelium is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0010129 name: femur cartilage element synonym: "femoral cartilage condensation" EXACT [] is_a: UBERON:0005254 ! upper leg mesenchyme is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010881 ! limb cartilage element is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015052 ! femur endochondral element [Term] id: UBERON:0010131 name: conducting tissue of heart synonym: "specialized conducting tissue of heart" EXACT [] synonym: "specialized muscle tissue of heart" EXACT [] is_a: UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0010133 name: neuroendocrine gland is_a: UBERON:0002368 ! endocrine gland [Term] id: UBERON:0010134 name: secretory circumventricular organ is_a: UBERON:0005408 ! circumventricular organ is_a: UBERON:0010133 ! neuroendocrine gland [Term] id: UBERON:0010147 name: male accessory sex gland synonym: "male accessory gland" RELATED [] is_a: UBERON:0005399 ! male reproductive gland [Term] id: UBERON:0010202 name: lateral line synonym: "lateral lines" EXACT [] is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0010243 name: merocrine gland is_a: UBERON:0002365 ! exocrine gland [Term] id: UBERON:0010260 name: umbilical blood vessel synonym: "allantoic vessel" EXACT [] synonym: "umbilical cord blood vessel" EXACT [] synonym: "umbilical cord blood vessels" RELATED [] synonym: "umbilical vasculature" RELATED [] synonym: "umbilical vessel" EXACT [] is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0010302 name: amnioserosa synonym: "amnion-serosa" RELATED [] is_a: UBERON:0010303 ! extraembryonic epithelium [Term] id: UBERON:0010303 name: extraembryonic epithelium synonym: "extra-embryonic epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005292 ! extraembryonic tissue [Term] id: UBERON:0010313 name: neural crest-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0010314 name: structure with developmental contribution from neural crest is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0010316 name: germ layer / neural crest is_a: UBERON:0005291 ! embryonic tissue [Term] id: UBERON:0010363 name: endochondral element synonym: "endochondral replacement element" EXACT [] is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0010365 name: odontoid tissue synonym: "dental tissue" RELATED [] synonym: "odontogenic tissue" EXACT [] synonym: "portion of substance of tooth" NARROW [] synonym: "substance of tooth" NARROW [] synonym: "tooth hard tissue" RELATED [] synonym: "tooth substance" NARROW [] synonym: "tooth tissue" RELATED [] is_a: UBERON:0004755 ! skeletal tissue is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0010371 name: ecto-epithelium synonym: "ectoderm-derived epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0010498 name: pseudostratified columnar epithelium is_a: UBERON:0000485 ! simple columnar epithelium [Term] id: UBERON:0010499 name: pseudostratified ciliated columnar epithelium synonym: "epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)" EXACT [] is_a: UBERON:0007592 ! ciliated columnar epithelium is_a: UBERON:0010498 ! pseudostratified columnar epithelium [Term] id: UBERON:0010521 name: electroreceptor organ synonym: "electric sense organ" EXACT [] synonym: "electroreception organ" EXACT [] is_a: UBERON:0000020 ! sense organ [Term] id: UBERON:0010523 name: microcirculatory vessel synonym: "microcirculatory vessels" RELATED [] is_a: UBERON:0000055 ! vessel [Term] id: UBERON:0010538 name: paired limb/fin segment synonym: "limb/fin segment" EXACT [] is_a: UBERON:0010758 ! subdivision of organism along appendicular axis [Term] id: UBERON:0010740 name: bone of appendage girdle complex synonym: "bone of extended limb/fin region" RELATED [] synonym: "limb bone" RELATED [] is_a: UBERON:0001474 ! bone element [Term] id: UBERON:0010742 name: bone of pelvic complex synonym: "hindlimb bone" RELATED [] is_a: UBERON:0010740 ! bone of appendage girdle complex [Term] id: UBERON:0010758 name: subdivision of organism along appendicular axis synonym: "appendage segment" EXACT [] synonym: "appendicular segment" EXACT [] is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0010881 name: limb cartilage element is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015061 ! limb endochondral element [Term] id: UBERON:0010882 name: limb bone pre-cartilage condensation is_a: UBERON:0015061 ! limb endochondral element [Term] id: UBERON:0010885 name: hindlimb cartilage element synonym: "hindlimb cartilage condensation" EXACT [] is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015022 ! hindlimb endochondral element [Term] id: UBERON:0010886 name: hindlimb pre-cartilage condensation synonym: "hindlimb pre-cartilage condensation" EXACT [] is_a: UBERON:0015022 ! hindlimb endochondral element [Term] id: UBERON:0010913 name: vertebral element is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0010959 name: craniocervical muscle synonym: "muscle of head and neck" RELATED [] synonym: "muscle of head or neck" EXACT [] is_a: UBERON:0014892 ! skeletal muscle organ [Term] id: UBERON:0010996 name: articular cartilage of joint synonym: "articular cartilage" EXACT [] synonym: "cartilago articularis" EXACT [] synonym: "hyaline cartilage" RELATED [] synonym: "joint-associated cartilage" RELATED [] is_a: UBERON:0001994 ! hyaline cartilage tissue [Term] id: UBERON:0011094 name: vertebra cartilage element synonym: "vertebral cartilage condensation" EXACT [] is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0010913 ! vertebral element is_a: UBERON:0015005 ! vertebra endochondral element [Term] id: UBERON:0011095 name: vertebra pre-cartilage condensation synonym: "vertebral pre-cartilage condensation" EXACT [] is_a: UBERON:0010913 ! vertebral element is_a: UBERON:0015005 ! vertebra endochondral element [Term] id: UBERON:0011134 name: nonsynovial joint synonym: "solid joint" EXACT [] is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0011139 name: synovial limb joint synonym: "synovial joint of free limb segment" EXACT [] is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0003657 ! limb joint [Term] id: UBERON:0011148 name: submucosal gland is_a: UBERON:0000414 ! mucous gland [Term] id: UBERON:0011197 name: parathyroid epithelium is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0006799 ! glandular epithelium [Term] id: UBERON:0011215 name: central nervous system cell part cluster synonym: "cell part cluster of neuraxis" EXACT [] synonym: "neuraxis layer" EXACT [] is_a: UBERON:0005162 ! multi cell part structure [Term] id: UBERON:0011216 name: organ system subdivision is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0011222 name: intra-ocular muscle synonym: "intrinsic muscle of eyeball" EXACT [] synonym: "intrinsic ocular muscle" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004277 ! eye muscle [Term] id: UBERON:0011300 name: gray matter of telencephalon synonym: "predominantly gray regional part of telencephalon" EXACT [] is_a: UBERON:0019264 ! gray matter of forebrain [Term] id: UBERON:0011374 name: prepuce is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034929 ! external soft tissue zone [Term] id: UBERON:0011585 name: cell condensation is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0011595 name: jaw region is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest [Term] id: UBERON:0011779 name: nerve of head region synonym: "cephalic nerve" RELATED [] synonym: "head nerve" RELATED [] is_a: UBERON:0001021 ! nerve [Term] id: UBERON:0011821 name: irregular connective tissue is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0011822 name: dense irregular connective tissue synonym: "irregular dense connective tissue" EXACT [] synonym: "typus irregularis (textus connectivus collagenosus compactus)" EXACT [] is_a: UBERON:0011821 ! irregular connective tissue is_a: UBERON:0011823 ! dense connective tissue [Term] id: UBERON:0011823 name: dense connective tissue is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0011825 name: loose connective tissue is_a: UBERON:0011821 ! irregular connective tissue [Term] id: UBERON:0011858 name: acinus of exocrine gland synonym: "exocrine gland acinus" EXACT [] is_a: UBERON:0009842 ! glandular acinus [Term] id: UBERON:0012069 name: epithelium-associated lymphoid tissue is_a: UBERON:0001744 ! lymphoid tissue [Term] id: UBERON:0012180 name: head or neck skin is_a: UBERON:0000014 ! zone of skin [Term] id: UBERON:0012274 name: columnar epithelium is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0012275 name: meso-epithelium synonym: "mesoderm-derived epithelium" EXACT [] synonym: "mesoepithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0012279 name: chromaffin paraganglion synonym: "chromaffin body" RELATED [] synonym: "chromaffin paraganglia" RELATED [] synonym: "chromaffin paraganglion" RELATED [] synonym: "paraganglion" BROAD [] is_a: UBERON:0034978 ! paraganglion (generic) [Term] id: UBERON:0012344 name: holocrine gland is_a: UBERON:0002365 ! exocrine gland [Term] id: UBERON:0012429 name: hemopoietic tissue synonym: "bone marrow tissue" NARROW [] synonym: "haemopoietic tissue" EXACT [] synonym: "hematopoietic tissue" EXACT [] synonym: "textus haemopoieticus" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034769 ! lymphomyeloid tissue [Term] id: UBERON:0013126 name: vein of abdomen synonym: "abdominal vein" EXACT [] is_a: UBERON:0001638 ! vein is_a: UBERON:0003497 ! abdomen blood vessel [Term] id: UBERON:0013192 name: ovarian medulla synonym: "medulla of ovary" EXACT [] synonym: "medulla ovarii (zona vasculosa)" EXACT [] synonym: "zona vasculosa of Waldeyer" RELATED [] is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0013232 name: serous acinus synonym: "acinus of serous gland" EXACT [] is_a: UBERON:0011858 ! acinus of exocrine gland [Term] id: UBERON:0013515 name: subdivision of oviduct synonym: "subdivision of fallopian tube" NARROW [] synonym: "subdivision of oviduct" EXACT [] synonym: "subdivision of uterine tube" EXACT [] synonym: "uterine tube zone" EXACT [] synonym: "zone of uterine tube" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube [Term] id: UBERON:0013522 name: subdivision of tube is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0013636 name: epithelium of intestinal villus synonym: "intestinal villus epithelium" EXACT [] synonym: "villous epithelium" RELATED [] synonym: "villus epithelium" RELATED [] is_a: UBERON:0001902 ! epithelium of small intestine [Term] id: UBERON:0013694 name: brain endothelium synonym: "cerebromicrovascular endothelium" RELATED [] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0013695 name: colon endothelium synonym: "colon endothelial cell" RELATED [] synonym: "colon endothelial cells" RELATED [] synonym: "colonic endothelial cell" RELATED [] synonym: "colonic endothelium" RELATED [] synonym: "colorectal endothelial cell" RELATED [] synonym: "colorectal endothelium" RELATED [] is_a: UBERON:0000397 ! colonic epithelium is_a: UBERON:0001986 ! endothelium [Term] id: UBERON:0013696 name: tonsil epithelium synonym: "epithelium of tonsil" RELATED [] synonym: "tonsil epithelial cell" RELATED [] is_a: UBERON:0003351 ! pharyngeal epithelium [Term] id: UBERON:0013697 name: exocrine pancreas epithelium synonym: "epithelium of exocrine pancreas" RELATED [] synonym: "exocrine pancreas epithelial cell" RELATED [] is_a: UBERON:0005911 ! endo-epithelium [Term] id: UBERON:0013754 name: integumentary system layer synonym: "layer of skin" NARROW [] synonym: "skin layer" NARROW [] is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0013765 name: digestive system element synonym: "digestive organ" EXACT [] synonym: "digestive system organ" EXACT [] is_a: UBERON:0000062 ! organ [Term] id: UBERON:0013768 name: great vessel of heart synonym: "great vessel" BROAD [] synonym: "great vessel of thorax" EXACT [] is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0014387 name: mesenchyme derived from neural crest synonym: "mesenchyme from neural crest" EXACT [] synonym: "neural crest derived mesenchyme" EXACT [] synonym: "neural crest mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0014401 name: renal venous blood vessel synonym: "kidney venous blood vessel" EXACT [] synonym: "kidney venous system" RELATED [] synonym: "venous blood vessel of kidney" EXACT [] is_a: UBERON:0003517 ! kidney blood vessel is_a: UBERON:0003920 ! venous blood vessel [Term] id: UBERON:0014892 name: skeletal muscle organ synonym: "skeletal muscle" BROAD [] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:0015005 name: vertebra endochondral element synonym: "vertebra element" EXACT [] synonym: "vertebra skeletal element" BROAD [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0002412 ! vertebra union_of: UBERON:0011094 ! vertebra cartilage element union_of: UBERON:0011095 ! vertebra pre-cartilage condensation [Term] id: UBERON:0015022 name: hindlimb endochondral element synonym: "hindlimb bone skeletal element" BROAD [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004765 ! skeletal element union_of: UBERON:0003464 ! hindlimb bone union_of: UBERON:0010885 ! hindlimb cartilage element union_of: UBERON:0010886 ! hindlimb pre-cartilage condensation [Term] id: UBERON:0015052 name: femur endochondral element synonym: "femur element" EXACT [] synonym: "femur skeletal element" BROAD [] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015061 ! limb endochondral element union_of: UBERON:0000981 ! femur union_of: UBERON:0006234 ! femur pre-cartilage condensation union_of: UBERON:0010129 ! femur cartilage element [Term] id: UBERON:0015061 name: limb endochondral element synonym: "limb bone endochondral element" EXACT [] synonym: "limb bone skeletal element" BROAD [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0002428 ! limb bone union_of: UBERON:0010881 ! limb cartilage element union_of: UBERON:0010882 ! limb bone pre-cartilage condensation [Term] id: UBERON:0015165 name: multi-unit eye is_a: UBERON:0000970 ! eye [Term] id: UBERON:0015172 name: endometrial blood vessel synonym: "blood vessel of endometrium" EXACT [] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0015212 name: lateral structure is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0015228 name: circulatory organ synonym: "cardiac pump" EXACT [] synonym: "cardiac structure" RELATED [] synonym: "circulatory vessel" NARROW [] synonym: "heart" BROAD [] synonym: "heart or heart like organ" EXACT [] is_a: UBERON:0003103 ! compound organ [Term] id: UBERON:0015249 name: digit skin is_a: UBERON:0015790 ! autopod skin [Term] id: UBERON:0015757 name: heterogeneous tissue synonym: "portion of heterogeneous tissue" EXACT [] is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0015790 name: autopod skin synonym: "paw skin" RELATED [] is_a: UBERON:0001419 ! skin of limb [Term] id: UBERON:0015796 name: liver blood vessel synonym: "hepatic blood vessel" RELATED [] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003497 ! abdomen blood vessel [Term] id: UBERON:0015807 name: ear epithelium is_a: UBERON:0019304 ! sensory organ epithelium [Term] id: UBERON:0015808 name: eye epithelium is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0015833 name: foregut epithelium is_a: UBERON:0003929 ! digestive tract epithelium [Term] id: UBERON:0016548 name: central nervous system gray matter layer synonym: "CNS gray matter layer" EXACT [] synonym: "CNS grey matter layer" EXACT [] synonym: "gray matter layer of neuraxis" EXACT [] synonym: "grey matter layer" BROAD [] synonym: "grey matter layer of neuraxis" EXACT [] is_a: UBERON:0022303 ! nervous system cell part layer [Term] id: UBERON:0016550 name: spinal cord column is_a: UBERON:0011215 ! central nervous system cell part cluster [Term] id: UBERON:0016885 name: epithelium of terminal part of digestive tract synonym: "rectum epithelium" NARROW [] is_a: UBERON:0003929 ! digestive tract epithelium [Term] id: UBERON:0017650 name: developing mesenchymal structure is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0017672 name: abdominal viscera synonym: "abdominal viscera" EXACT [] synonym: "abdominal viscera set" EXACT [] synonym: "set of abdominal viscera" EXACT [] is_a: UBERON:0002075 ! viscus is_a: UBERON:0005172 ! abdomen element [Term] id: UBERON:0018260 name: layer of muscle tissue is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0018649 name: cardiac muscle tissue of ventricle synonym: "ventricular cardiac muscle tissue" EXACT [] synonym: "ventricular heart muscle" EXACT [] synonym: "ventricular muscle" RELATED [] is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium [Term] id: UBERON:0018707 name: bladder organ synonym: "bladder" NARROW [] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0009856 ! sac [Term] id: UBERON:0019042 name: reproductive system mucosa synonym: "genital mucosa" EXACT [] is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure [Term] id: UBERON:0019263 name: gray matter of hindbrain synonym: "gray matter of the hindbrain" EXACT [] is_a: UBERON:0003528 ! brain gray matter [Term] id: UBERON:0019264 name: gray matter of forebrain is_a: UBERON:0003528 ! brain gray matter [Term] id: UBERON:0019304 name: sensory organ epithelium is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0019306 name: nose epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0019304 ! sensory organ epithelium [Term] id: UBERON:0019319 name: exocrine gland of integumental system synonym: "integumental exocrine gland" EXACT [] synonym: "integumental system exocrine gland" EXACT [] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003297 ! gland of integumental system [Term] id: UBERON:0022303 name: nervous system cell part layer synonym: "lamina" BROAD [] synonym: "layer" BROAD [] is_a: UBERON:0005162 ! multi cell part structure [Term] id: UBERON:0022351 name: parietal serous membrane synonym: "parietal wall of serous membrane" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer [Term] id: UBERON:0034713 name: cranial neuron projection bundle synonym: "cranial nerve fiber bundle" RELATED [] synonym: "cranial nerve fiber tract" RELATED [] synonym: "cranial nerve or tract" RELATED [] synonym: "neuron projection bundle from brain" RELATED [] is_a: UBERON:0000122 ! neuron projection bundle [Term] id: UBERON:0034769 name: lymphomyeloid tissue is_a: UBERON:0015757 ! heterogeneous tissue [Term] id: UBERON:0034921 name: multi organ part structure synonym: "anatomical cluster" RELATED [] is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0034922 name: cell cluster is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0034929 name: external soft tissue zone is_a: UBERON:0010000 ! multicellular anatomical structure [Term] id: UBERON:0034932 name: epithelium of biliary system synonym: "biliary epithelium" RELATED [] synonym: "biliary system epithelium" EXACT [] synonym: "biliary tract epithelium" RELATED [] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0034933 name: layer of smooth muscle tissue is_a: UBERON:0018260 ! layer of muscle tissue [Term] id: UBERON:0034943 name: saccus vasculosus is_a: UBERON:0005408 ! circumventricular organ [Term] id: UBERON:0034944 name: zone of organ synonym: "organ sector" EXACT [] synonym: "organ zonal region" EXACT [] synonym: "organ zone" EXACT [] is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0034969 name: epithelial layer of duct synonym: "duct epithelium" RELATED [] synonym: "ductal epithelium" RELATED [] is_a: UBERON:0003914 ! epithelial tube [Term] id: UBERON:0034978 name: paraganglion (generic) synonym: "paraganglia" RELATED [] is_a: UBERON:0010001 ! cell cluster organ is_a: UBERON:0010313 ! neural crest-derived structure [Term] id: UBERON:0035037 name: jaw epithelium is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0010371 ! ecto-epithelium [Term] id: UBERON:0035553 name: left cardiac chamber is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0035554 name: right cardiac chamber is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure [Term] id: UBERON:0035555 name: lateral line sense organ is_a: UBERON:0010521 ! electroreceptor organ [Term] id: UBERON:1000021 name: skin of face synonym: "face skin" EXACT [] synonym: "facial skin" RELATED [] is_a: UBERON:0001084 ! skin of head [Term] id: UBERON:1000023 name: spleen pulp synonym: "malpighian corpuscles" EXACT [] synonym: "pulp of spleen" EXACT [] synonym: "splenic pulp" EXACT [] is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure [Term] id: UBERON:2000120 name: lateral line ganglion synonym: "lateral line ganglia" EXACT [] synonym: "LLG" EXACT [] is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:2000175 name: posterior lateral line nerve synonym: "caudal lateral line nerve" EXACT [] is_a: UBERON:0008906 ! lateral line nerve [Term] id: UBERON:2000425 name: anterior lateral line nerve synonym: "rostral lateral line nerve" EXACT [] is_a: UBERON:0008906 ! lateral line nerve [Term] id: UBERON:2001314 name: posterior lateral line ganglion is_a: UBERON:2000120 ! lateral line ganglion [Term] id: UBERON:2001391 name: anterior lateral line ganglion synonym: "anterior lateral line ganglia" RELATED [] is_a: UBERON:2000120 ! lateral line ganglion [Term] id: UBERON:2001470 name: anterior lateral line is_a: UBERON:0010202 ! lateral line [Term] id: UBERON:2005260 name: fenestrated capillary synonym: "fenestrated blood vessel endothelium" BROAD [] synonym: "fenestrated capillary vessel" EXACT [] is_a: UBERON:0001982 ! capillary is_a: UBERON:0004638 ! blood vessel endothelium [Term] id: UBERON:3000961 name: external integument structure is_a: UBERON:0003102 ! surface structure [Term] id: UBERON:4000013 name: mineralized skeletal tissue synonym: "mineralized tissue" BROAD [] is_a: UBERON:0004755 ! skeletal tissue [Term] id: http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 name: alobate nucleus is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0002506 ! alobate relationship: bearer_of PATO:0002506 ! alobate [Typedef] id: adjacent_to name: adjacent_to xref: RO:0002220 [Typedef] id: bearer_of name: bearer of xref: BFO:0000053 [Typedef] id: capable_of name: capable_of def: "A relation between a material entity (such as a cell) and a process. This is a shortcut relation, translation rule for which is: capable_of P <-> bearer_of (some realized_by only P). Example: osteoclast capable of bone resorption." [GOC:cjm] xref: RO:0002215 expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000053 some (http://purl.obolibrary.org/obo/BFO_0000054 only ?Y)" [] [Typedef] id: develops_from name: develops_from xref: RO:0002202 [Typedef] id: develops_into name: develops into xref: RO:0002203 is_transitive: true inverse_of: develops_from ! develops_from [Typedef] id: has_completed name: has_completed xref: has_completed [Typedef] id: has_high_plasma_membrane_amount name: has_high_plasma_membrane_amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] xref: has_high_plasma_membrane_amount is_a: has_plasma_membrane_part ! has_plasma_membrane_part [Typedef] id: has_low_plasma_membrane_amount name: has_low_plasma_membrane_amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] xref: has_low_plasma_membrane_amount is_a: has_plasma_membrane_part ! has_plasma_membrane_part [Typedef] id: has_not_completed name: has_not_completed xref: has_not_completed [Typedef] id: has_part name: has_part xref: BFO:0000051 is_transitive: true [Typedef] id: has_plasma_membrane_part name: has_plasma_membrane_part def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." [PMID:19243617] xref: RO:0002104 is_a: has_part ! has_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] [Typedef] id: has_relational_adjective name: has_relational_adjective namespace: uberon comment: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. xref: UBPROP:0000007 is_metadata_tag: true [Typedef] id: has_synaptic_terminal_in name: has synaptic terminal in xref: RO:0002130 [Typedef] id: immediate_transformation_of name: immediate_transformation_of synonym: "direct_transformation_of" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "immediately transforms from" EXACT [SIO:000658] xref: http://semanticscience.org/resource/SIO_000658 xref: SIO:000658 property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl [Typedef] id: lacks_part name: lacks_part xref: lacks_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y" [] [Typedef] id: lacks_plasma_membrane_part name: lacks_plasma_membrane_part xref: lacks_plasma_membrane_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] [Typedef] id: negatively_regulates name: negatively_regulates xref: RO:0002212 is_a: regulates ! regulates [Typedef] id: occurs_in name: occurs in xref: BFO:0000066 transitive_over: part_of ! part_of [Typedef] id: overlaps name: overlaps xref: RO:0002131 [Typedef] id: part_of name: part_of xref: BFO:0000050 is_transitive: true inverse_of: has_part ! has_part [Typedef] id: participates_in name: participates in xref: BFO:0000056 [Typedef] id: positively_regulates name: positively_regulates xref: RO:0002213 is_a: regulates ! regulates [Typedef] id: produces name: produces xref: RO:0003000 [Typedef] id: realized_by name: realized by xref: BFO:0000054 [Typedef] id: regulates name: regulates xref: RO:0002211 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl transitive_over: part_of ! part_of [Typedef] id: seeAlso name: see also namespace: uberon xref: http://www.w3.org/2000/01/rdf-schema#seeAlso is_metadata_tag: true [Typedef] id: synapsed_to name: synapsed to xref: RO:0002120