format-version: 1.2 date: 19:10:2009 13:49 saved-by: djs93 auto-generated-by: OBO-Edit 2.1-beta1 default-namespace: FlyBase development CV namespace-id-rule: * FBdv:$sequence(8,7000,17000)$ remark: Drosophila temporal ontology. CVS version 1.17 [Term] id: FBdv:00000054 name: cleavage stage def: "A collective term for stages 1-4." [FBC:DOS] comment: Temporal ordering number - 25. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005288 ! fertilized egg stage [Term] id: FBdv:00004450 name: late extended germ band stage def: "A collective term for stages 11 and 12." [FBC:DOS] comment: Temporal ordering number - 300. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005321 ! extended germ band stage relationship: starts_at_end_of FBdv:00005324 ! embryonic stage 10 relationship: starts_at_end_of FBdv:00014201 ! early extended germ band stage [Term] id: FBdv:00004886 name: oogenesis stage comment: Temporal ordering number - 10000. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle [Term] id: FBdv:00005259 name: developmental stage alt_id: FBdv:00007010 def: "A temporal subdivision of a developmental process." [FBC:DOS] is_a: FBdv:00007008 ! occurrent created_by: djs93 creation_date: 2009-10-01T05:56:56Z [Term] id: FBdv:00005261 name: oogenesis stage S1 def: "Earliest stage of ovarian cyst development - lasts while the 16 cell cyst is within the germarium (region 3)." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10010. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage [Term] id: FBdv:00005262 name: oogenesis stage S2 def: "Oogenesis stage that begins when the cyst leaves the germarium (from this point the cyst is referred to as an egg chamber). During this stage, polyploidation of the nurse cells begins, they reach a ploidy of 8C, and follicle cells start to divide." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10020. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005261 ! oogenesis stage S1 [Term] id: FBdv:00005263 name: oogenesis stage S3 def: "Oogenesis stage that begins when the oocyte chromosomes condense into a karyosome attached to a distinctive spherical structure known as an endobody. The oocyte nucleolus disappears completely. During this stage, nurse cell ploidy reaches 16C." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10030. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005262 ! oogenesis stage S2 [Term] id: FBdv:00005264 name: oogenesis stage S4 def: "Oogenesis stage that begins when the nurse cells chromosomes become bulbous. Nurse cell chromosomes during this stage are polytene and reach a ploidy of 32C. The egg chamber is oval shaped." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10040. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005263 ! oogenesis stage S3 [Term] id: FBdv:00005265 name: oogenesis stage S5 def: "Oogenesis stage that begins when nurse cell chromosomes are no longer bulbous - the association between homologs weakens so that these chromosomes no longer have a polytene structure. During this stage, posterior nurse cell nuclei have a higher ploidy (64C) than anterior ones." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10050. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005264 ! oogenesis stage S4 [Term] id: FBdv:00005266 name: oogenesis stage S6 def: "Oogenesis stage during which follicle cell division ceases." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10060. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005265 ! oogenesis stage S5 [Term] id: FBdv:00005267 name: oogenesis stage S7 def: "Oogenesis stage during which polyploidation and enlargement of follicle cells begins. Nurse cell ploidy ranges from 256C (anterior) to 512C (posterior) and the egg chamber gains an elongated shape." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10070. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005266 ! oogenesis stage S6 [Term] id: FBdv:00005268 name: oogenesis stage S8 def: "Oogenesis stage which begins when yolk first appears in the oocyte. Follicle cell migration over the oocyte begins during this stage (although mostly occurs during stage 9)." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10080. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005267 ! oogenesis stage S7 [Term] id: FBdv:00005269 name: oogenesis stage S9 def: "Oogenesis stage that begins when the border cells begin to migrate. During this stage: the oocyte is about 1/3 the length of the egg chamber with its nucleus located antero-dorsally; follicle cell migration results in an anterior to posterior gradient of follicle cell thickness with posterior cells being thicker (-> columnar) and posterior cells thinner ( -> squamous); border cell migration begins and ends; secretion of vitelline membrane begins." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10090. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005268 ! oogenesis stage S8 [Term] id: FBdv:00005270 name: oogenesis stage S10 def: "." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10100. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005269 ! oogenesis stage S9 [Term] id: FBdv:00005271 name: oogenesis stage S10A def: "Oogenesis which begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous. During this stage, the migrating border cells reach the oocyte. The oocyte is about 50% egg chamber length." [FlyBase:FBrf0021038, FlyBase:FBrf0034074] comment: Temporal ordering number - 10110. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005270 ! oogenesis stage S10 relationship: starts_at_end_of FBdv:00005269 ! oogenesis stage S9 [Term] id: FBdv:00005272 name: oogenesis stage S10B def: "Oogenesis stage that begins when the centripetal follicle cells begin to migrate. As a result, the vitelline membrane extends into the opercular region." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10120. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005270 ! oogenesis stage S10 relationship: starts_at_end_of FBdv:00005271 ! oogenesis stage S10A [Term] id: FBdv:00005273 name: oogenesis stage S11 def: "Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins. The dorsal appendages begin to form during this stage." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0043885, FlyBase:FBrf0064777] comment: Temporal ordering number - 10130. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005270 ! oogenesis stage S10 relationship: starts_at_end_of FBdv:00005272 ! oogenesis stage S10B [Term] id: FBdv:00005274 name: oogenesis stage S12 def: "Oogenesis stage that begins when dying nurse cells form an anterior cap to the oocyte. Shortly after this, nurse cell dumping and growth of the oocyte are complete. Elongation of the dorsal appendages and formation of the innermost chorionic layer and endochondrion begins during this stage." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0043885, FlyBase:FBrf0064777] comment: Temporal ordering number - 10160. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005273 ! oogenesis stage S11 [Term] id: FBdv:00005275 name: oogenesis stage S12A def: "Innermost chorionic layer and endochondrion begin to form in the anterior of the follicle." [FlyBase:FBrf0043885] comment: Temporal ordering number - 10170. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005274 ! oogenesis stage S12 relationship: starts_at_end_of FBdv:00005273 ! oogenesis stage S11 [Term] id: FBdv:00005276 name: oogenesis stage S12B def: "Secretion of innermost chorionic layer and endochondrion begins in the main follicle cells." [FlyBase:FBrf0043885] comment: Temporal ordering number - 10180. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005274 ! oogenesis stage S12 relationship: starts_at_end_of FBdv:00005275 ! oogenesis stage S12A [Term] id: FBdv:00005277 name: oogenesis stage S12C def: "Formation of specialized endochondrion structures in the anterior of the follicle: branches in the developing dorsal appendages; compact endochondrion lacking the pillars seen in the rest of the follicle." [FlyBase:FBrf0021038] comment: Temporal ordering number - 10190. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005274 ! oogenesis stage S12 relationship: starts_at_end_of FBdv:00005276 ! oogenesis stage S12B [Term] id: FBdv:00005278 name: oogenesis stage S13 def: "Oogenesis stage that begins when the micropile begins to form. At the beginning of this stage, about 12-15 nurse cell nuclei remain at the anterior of the oocyte. By the end of this stage, none of these nuclei remain. Oocyte meiosis up to arrest at full metaphase I occurs during this stage." [FlyBase:FBrf0021038, FlyBase:FBrf0029744, FlyBase:FBrf0034074, FlyBase:FBrf0064777] comment: Temporal ordering number - 10200. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005274 ! oogenesis stage S12 relationship: starts_at_end_of FBdv:00005277 ! oogenesis stage S12C [Term] id: FBdv:00005279 name: oogenesis stage S13A def: "Oogenesis stage during which 12-15 nurse cell nuclei remain at the anterior of the oocyte. At this stage, the oocyte nucleus has reached its maximum volume and its chromosomes are compressed into a 5-7 micrometer karyosome." [FlyBase:FBrf0029744] comment: Temporal ordering number - 10210. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005278 ! oogenesis stage S13 relationship: starts_at_end_of FBdv:00005277 ! oogenesis stage S12C [Term] id: FBdv:00005280 name: oogenesis stage S13B def: "Oogenesis stage during which 9-11 nurse cell nuclei remain at the anterior of the oocyte. During this stage, the nuclear membrane of the oocyte nucleus disappears, indicating the start of meiotic pro-metaphase." [FlyBase:FBrf0029744] comment: Temporal ordering number - 10220. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005278 ! oogenesis stage S13 relationship: starts_at_end_of FBdv:00005279 ! oogenesis stage S13A [Term] id: FBdv:00005281 name: oogenesis stage S13C def: "Oogenesis stage during which only 7-8 nurse cell nuclei remain at the anterior of the oocyte. At the beginning of this stage, oocyte chromosome bivalents separate from each other - indicating mid-prometaphase of oocyte meiosis." [FlyBase:FBrf0029744] comment: Temporal ordering number - 10230. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005278 ! oogenesis stage S13 relationship: starts_at_end_of FBdv:00005280 ! oogenesis stage S13B [Term] id: FBdv:00005282 name: oogenesis stage S13D def: "Oogenesis stage during which only 5-6 nurse cell nuclei remain at the anterior of the oocyte. The oocyte nucleus is in late prometaphase:the bivalents arrange themselves in on the equatorial plane of the spindle; homologous centromeres are pulled towards the poles." [FlyBase:FBrf0029744] comment: Temporal ordering number - 10240. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005278 ! oogenesis stage S13 relationship: starts_at_end_of FBdv:00005281 ! oogenesis stage S13C [Term] id: FBdv:00005283 name: oogenesis stage S14 def: "The last stage of oogenesis. This stage begins when no nurse cell nuclei remain at the anterior of the egg (chamber). Exochorion formation and secretion occurs during this stage. The dorsal appendages complete their elongation and the follicle cells die." [FlyBase:FBrf0043885] comment: Temporal ordering number - 10260. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004886 ! oogenesis stage relationship: starts_at_end_of FBdv:00005278 ! oogenesis stage S13 relationship: starts_at_end_of FBdv:00005282 ! oogenesis stage S13D [Term] id: FBdv:00005284 name: oogenesis stage S14A def: "Secretion and formation of the outer endochorionic network by throughout the follicle. Crystallization of the innermost chorionic layer of the main body follicle cells." [FlyBase:FBrf0021038, FlyBase:FBrf0043885] comment: Temporal ordering number - 10270. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005283 ! oogenesis stage S14 relationship: starts_at_end_of FBdv:00005282 ! oogenesis stage S13D [Term] id: FBdv:00005285 name: oogenesis stage S14B def: "Secretion of the exochorion begins and ends." [FlyBase:FBrf0021038, FlyBase:FBrf0043885] comment: Temporal ordering number - 10280. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005283 ! oogenesis stage S14 relationship: starts_at_end_of FBdv:00005284 ! oogenesis stage S14A [Term] id: FBdv:00005286 name: egg stage is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle comment: Temporal ordering number - 10290. [Term] id: FBdv:00005287 name: unfertilized egg stage comment: Temporal ordering number - 10300. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005286 ! egg stage relationship: starts_at_end_of FBdv:00005283 ! oogenesis stage S14 relationship: starts_at_end_of FBdv:00005285 ! oogenesis stage S14B [Term] id: FBdv:00005288 name: fertilized egg stage comment: Temporal ordering number - 10. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005286 ! egg stage relationship: starts_at_end_of FBdv:00005287 ! unfertilized egg stage [Term] id: FBdv:00005289 name: embryonic stage comment: Temporal ordering number - 20. is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle relationship: starts_at_end_of FBdv:00005288 ! fertilized egg stage [Term] id: FBdv:00005290 name: pre-blastoderm stage def: "Embryonic stage 1-3." [FBC:DOS] comment: Temporal ordering number - 30. synonym: "pre-blastoderm" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005288 ! fertilized egg stage [Term] id: FBdv:00005291 name: embryonic stage 1 def: "Nuclear divisions 1 and 2. Duration at 25 degrees C\\: approximately 25 minutes (0-25 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 40. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00000054 ! cleavage stage relationship: part_of FBdv:00005290 ! pre-blastoderm stage relationship: starts_at_end_of FBdv:00005288 ! fertilized egg stage [Term] id: FBdv:00005292 name: embryonic cycle 1 def: "The first nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 50. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005291 ! embryonic stage 1 relationship: starts_at_end_of FBdv:00005288 ! fertilized egg stage [Term] id: FBdv:00005293 name: embryonic stage 2 def: "Nuclear divisions 3-8. The egg cytoplasm contracts producing a clear separation from the vitelline membrane and empty spaces at the anterior and posterior. The cleavage nuclei migrate towards the periphery. Duration at 25 degrees C approximately 40 minutes (25-65 minutes AEL)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 70. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00000054 ! cleavage stage relationship: part_of FBdv:00005290 ! pre-blastoderm stage relationship: starts_at_end_of FBdv:00005291 ! embryonic stage 1 [Term] id: FBdv:00005294 name: embryonic cycle 2 def: "The second nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 60. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005292 ! embryonic cycle 1 [Term] id: FBdv:00005295 name: embryonic cycle 3 def: "The third nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 80. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005291 ! embryonic stage 1 relationship: starts_at_end_of FBdv:00005294 ! embryonic cycle 2 [Term] id: FBdv:00005296 name: embryonic cycle 4 def: "The fourth nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 90. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005295 ! embryonic cycle 3 [Term] id: FBdv:00005297 name: embryonic cycle 5 def: "The fifth nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 100. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005296 ! embryonic cycle 4 [Term] id: FBdv:00005298 name: embryonic cycle 6 def: "The sixth nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 110. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005297 ! embryonic cycle 5 [Term] id: FBdv:00005299 name: embryonic cycle 7 def: "The seventh nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 120. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005298 ! embryonic cycle 6 [Term] id: FBdv:00005300 name: embryonic cycle 8 def: "The eight nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 130. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005299 ! embryonic cycle 7 [Term] id: FBdv:00005301 name: embryonic stage 3 def: "Nuclear division 9. The cleavage nuclei complete their migration to the periphery. Polar buds form at the posterior pole and divide once. Duration at 25 degrees C: approximately 15 minutes (65-80 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 140. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00000054 ! cleavage stage relationship: part_of FBdv:00005290 ! pre-blastoderm stage relationship: starts_at_end_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005300 ! embryonic cycle 8 [Term] id: FBdv:00005302 name: embryonic cycle 9 def: "The ninth nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 150. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005301 ! embryonic stage 3 relationship: starts_at_end_of FBdv:00005293 ! embryonic stage 2 relationship: starts_at_end_of FBdv:00005300 ! embryonic cycle 8 [Term] id: FBdv:00005303 name: embryonic cycle 10 def: "The tenth nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 180. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005306 ! embryonic stage 4 relationship: starts_at_end_of FBdv:00005301 ! embryonic stage 3 relationship: starts_at_end_of FBdv:00005302 ! embryonic cycle 9 [Term] id: FBdv:00005304 name: blastoderm stage def: "Embryonic stages 4 and 5." [FBC:DOS] comment: Temporal ordering number - 160. synonym: "blastoderm" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005290 ! pre-blastoderm stage relationship: starts_at_end_of FBdv:00005301 ! embryonic stage 3 [Term] id: FBdv:00005305 name: syncytial blastoderm stage is_obsolete: true [Term] id: FBdv:00005306 name: embryonic stage 4 def: "Nuclear division 10-13. Polar buds divide twice and become tightly grouped at the posterior pole by the end of this stage. Nuclei visible at the rim of the embryo. Stage 4 ends with the beginning of cellularization. Duration at 25 degrees C: approx. 50 minutes (80-130 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 170. synonym: "syncytial blastoderm" RELATED [] synonym: "syncytial blastoderm stage" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00000054 ! cleavage stage relationship: part_of FBdv:00005304 ! blastoderm stage relationship: starts_at_end_of FBdv:00005290 ! pre-blastoderm stage relationship: starts_at_end_of FBdv:00005301 ! embryonic stage 3 relationship: starts_at_end_of FBdv:00005302 ! embryonic cycle 9 [Term] id: FBdv:00005307 name: embryonic cycle 11 def: "The 11th nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 185. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005306 ! embryonic stage 4 relationship: starts_at_end_of FBdv:00005303 ! embryonic cycle 10 [Term] id: FBdv:00005308 name: embryonic cycle 12 def: "The 12th nuclear division of embryogenesis. This division is synchronous across the embryo." [FlyBase:FBrf0089570] comment: Temporal ordering number - 190. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005306 ! embryonic stage 4 relationship: starts_at_end_of FBdv:00005307 ! embryonic cycle 11 [Term] id: FBdv:00005309 name: embryonic cycle 13 def: "The 13th nuclear division of embryogenesis. This is the last synchronous division." [FlyBase:FBrf0089570] comment: Temporal ordering number - 200. is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005306 ! embryonic stage 4 relationship: starts_at_end_of FBdv:00005308 ! embryonic cycle 12 [Term] id: FBdv:00005310 name: cellular blastoderm stage is_obsolete: true [Term] id: FBdv:00005311 name: embryonic stage 5 def: "Cellularization. Stage 5 begins when cellularization starts. Near the end of this stage the pole cells begin to migrate dorsally and ventral midline cells acquire an irregular, wavy appearance. Stage 5 ends when ventral furrow formation becomes apparent. Duration at 25 degrees: approximately 40 minutes (130-170 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 210. synonym: "cellular blastoderm" RELATED [] synonym: "cellular blastoderm stage" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005304 ! blastoderm stage relationship: starts_at_end_of FBdv:00000054 ! cleavage stage relationship: starts_at_end_of FBdv:00005306 ! embryonic stage 4 [Term] id: FBdv:00005312 name: embryonic cycle 14 def: "The 14th nuclear division of embryogenesis. This is the first round of nuclear division to occur in a cellularized embryo, so this is the first round of cell division. Cycle 14 is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains." [FlyBase:FBrf0049535, FlyBase:FBrf0089570] comment: Temporal ordering number - 255. synonym: "first blastoderm mitosis" EXACT [FlyBase:FBrf0089570] is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005309 ! embryonic cycle 13 [Term] id: FBdv:00005313 name: embryonic cycle 14A is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005312 ! embryonic cycle 14 comment: Temporal ordering number - 256. [Term] id: FBdv:00005314 name: embryonic cycle 14B is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005312 ! embryonic cycle 14 comment: Temporal ordering number - 257. [Term] id: FBdv:00005315 name: embryonic cycle 15 def: "The 15th nuclear division of embryogenesis. Asynchronous." [FlyBase:FBrf0089570] comment: Temporal ordering number - 285. synonym: "second blastoderm mitosis" EXACT [FlyBase:FBrf0089570] is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005289 ! embryonic stage [Term] id: FBdv:00005316 name: embryonic cycle 16 def: "The 16th nuclear division of embryogenesis. Asynchronous." [FlyBase:FBrf0089570] comment: Temporal ordering number - 295. synonym: "third blastoderm mitosis" RELATED [FlyBase:FBrf0089570] is_a: FBdv:00007011 ! embryonic cycle relationship: part_of FBdv:00005289 ! embryonic stage [Term] id: FBdv:00005317 name: gastrula stage def: "Stages during which gastrulation occurs. 6-8." [FBC:DOS] comment: Temporal ordering number - 220. synonym: "gastrula" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005304 ! blastoderm stage relationship: starts_at_end_of FBdv:00005311 ! embryonic stage 5 [Term] id: FBdv:00005318 name: embryonic stage 6 def: "Stage 6 begins when the ventral furrow becomes apparent, an event which is followed rapidly by the formation of the cephalic furrow. Stage 6 ends when the pole cells have adopted a dorsal (horizontal) position at the posterior. Duration at 25 degrees C: approximately 10 minutes (170-180 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 230. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005317 ! gastrula stage relationship: starts_at_end_of FBdv:00005304 ! blastoderm stage relationship: starts_at_end_of FBdv:00005311 ! embryonic stage 5 [Term] id: FBdv:00005319 name: embryonic stage 7 def: "Stage 7 begins when the pole cells have adopted a dorsal (horizontal) position at the posterior. Invagination of the anterior and posterior midgut and hindgut follows. The 'discoid plate' that carries the pole cells forms a pocket. Transverse furrows (dorsal folds) form on the dorsal surface. This stage ends when the anterior wall of the amnioproctodeal invagination starts moving anteriorly and the pole cells are no longer visible externally. Duration at 25 degrees C: approximately 10 minutes (180-190 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 240. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005317 ! gastrula stage relationship: starts_at_end_of FBdv:00005318 ! embryonic stage 6 [Term] id: FBdv:00005320 name: germ band stage is_obsolete: true [Term] id: FBdv:00005321 name: extended germ band stage def: "Stages during which the germ band is extended - 9-12." [FBC:DOS] comment: Temporal ordering number - 260. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005317 ! gastrula stage relationship: starts_at_end_of FBdv:00005322 ! embryonic stage 8 [Term] id: FBdv:00005322 name: embryonic stage 8 def: "Stage 8 starts with the rapid phase of germ band extension and ends with the beginning of mesodermal segmentation. By the end of this stage germ band extension has progressed to the point where the proctodeal opening is at about 60% egg length and the dorsal folds (transverse furrows) are no longer visible. Duration at 25 degrees C: approximately 30 minutes (190-220 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 250. synonym: "rapidly extending germ band stage" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005317 ! gastrula stage relationship: starts_at_end_of FBdv:00005319 ! embryonic stage 7 [Term] id: FBdv:00005323 name: embryonic stage 9 def: "Stage 9 begins when mesodermal segmentation becomes (transiently) visible\\, and ends with the appearance of the stomodeal invagination slightly ventral to the anterior pole. Duration at 25 degrees C: approximately 40 minutes (220-260 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 280. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00014201 ! early extended germ band stage relationship: starts_at_end_of FBdv:00005317 ! gastrula stage relationship: starts_at_end_of FBdv:00005322 ! embryonic stage 8 [Term] id: FBdv:00005324 name: embryonic stage 10 def: "Stage 10 begins with the appearance of the stomodeal invagination, slightly ventral to the anterior pole. Periodic furrows appear in the embryonic epidermis around the middle of the stage. The germ band continues to extend, reaching its maximum extent of 75% egg length towards the end of the stage. The end of the stage is marked by the beginning of invagination of the tracheal placodes. Duration at 25 degrees : approximately 60 minutes (260-320 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 290. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00014201 ! early extended germ band stage relationship: starts_at_end_of FBdv:00005323 ! embryonic stage 9 [Term] id: FBdv:00005325 name: embryonic stage 11 def: "Stage 11 begins with the invagination of the tracheal placodes. Para-segmental furrow form and segment boundary furrows become deep folds. Within the head, gnathal protuberances become apparent. The end of this stage is signaled by the appearance of a distinct cleft at the posterior pole of the embryo, which becomes detached from the vitelline membrane. This marks the beginning of germ-band retraction. Duration at 25 degrees C: approximately 120 minutes (320-440 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 310. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004450 ! late extended germ band stage relationship: starts_at_end_of FBdv:00005324 ! embryonic stage 10 relationship: starts_at_end_of FBdv:00014201 ! early extended germ band stage [Term] id: FBdv:00005326 name: contracted germ band stage is_obsolete: true [Term] id: FBdv:00005327 name: embryonic stage 12 def: "Germ band retraction. Stage 12 begins when germ-band retraction starts and ends when this process is complete so that the prospective anal plate occupies the posterior pole. During this stage the posterior and anterior hindgut primordia meet and fuse and the tracheal pits fuse to form the tracheal tree. Duration at 25 degrees C: approximately 120 minutes (440-560 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 320. synonym: "retracting germ band stage" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00004450 ! late extended germ band stage relationship: starts_at_end_of FBdv:00005325 ! embryonic stage 11 [Term] id: FBdv:00005328 name: embryonic stage 13 def: "Stage 13 begins at the completion of germ-band retraction, when the prospective anal plate occupy the posterior pole. The dorsal ridge becomes apparent externally; the clypeolabrum retracts, leaving a triangular shaped gap at the anterior pole; the labium moves to the ventral midline. This stage ends when head involution begins. Duration at 25 degrees C: Approximately 60 minutes (560-620 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 340. synonym: "contracted germ band stage" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005331 ! dorsal closure stage relationship: starts_at_end_of FBdv:00004450 ! late extended germ band stage relationship: starts_at_end_of FBdv:00005321 ! extended germ band stage relationship: starts_at_end_of FBdv:00005327 ! embryonic stage 12 [Term] id: FBdv:00005329 name: head involution stage is_obsolete: true [Term] id: FBdv:00005330 name: embryonic stage 14 def: "Stage 14 begins with the initiation of head involution. Closure of the midgut around the yolk and dorsal closure continue. Dorsal closure is 80% complete by the end of this stage. This stage ends with the appearance of the second midgut constriction. Duration at 25 degrees C: approximately 60 minutes (620-680 minutes after egg laying)" [FlyBase:FBrf0089570] comment: Temporal ordering number - 350. synonym: "head involution stage" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005331 ! dorsal closure stage relationship: starts_at_end_of FBdv:00005328 ! embryonic stage 13 [Term] id: FBdv:00005331 name: dorsal closure stage def: "A collective term for stages 13-15." [FBC:DOS] comment: Temporal ordering number - 330. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00004450 ! late extended germ band stage relationship: starts_at_end_of FBdv:00005321 ! extended germ band stage relationship: starts_at_end_of FBdv:00005327 ! embryonic stage 12 [Term] id: FBdv:00005332 name: embryonic stage 15 def: "Stage 15 begins with the appearance of the second midgut constriction. During this stage the 1st and 3rd midgut constrictions form, dorsal closure is completed, and epidermal segmentation is accomplished. This stage ends when the intersegmental grooves can be distinguished at mid-dorsal level. Duration at 25 degrees C: approximately 100 minutes (680-780 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 360. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005331 ! dorsal closure stage relationship: starts_at_end_of FBdv:00005330 ! embryonic stage 14 [Term] id: FBdv:00005333 name: late embryonic stage def: "Embryonic stages 16-17." [FBC:DOS] comment: Temporal ordering number - 370. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005331 ! dorsal closure stage relationship: starts_at_end_of FBdv:00005332 ! embryonic stage 15 [Term] id: FBdv:00005334 name: embryonic stage 16 def: "Stage 16 begins when the intersegmental grooves can be distinguished at mid-dorsal level, and ends when the dorsal ridge (frontal sac) has overgrown the tip of the cylpeolabrum, which is thereby enclosed in the atrium. During this stage the ventral cord retracts to about 60% egg length. Duration at 25 degrees C: approximately 180 minutes (780-960 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 380. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005333 ! late embryonic stage relationship: starts_at_end_of FBdv:00005331 ! dorsal closure stage relationship: starts_at_end_of FBdv:00005332 ! embryonic stage 15 [Term] id: FBdv:00005335 name: embryonic stage 17 def: "Stage 17 begins when the dorsal ridge (frontal sac) has overgrown the tip of the cylpeolabrum, which is thereby enclosed in the atrium. It lasts until hatching of the embryo (approximately 24 hours after egg laying), during which time much terminal differentiation occurs, the tracheal tree fills with air, so becoming completely visible, and the ventral cord continues to retract. Duration at 25 degrees C: approximately 8 hours (960-1440 minutes after egg laying)." [FlyBase:FBrf0089570] comment: Temporal ordering number - 390. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005333 ! late embryonic stage relationship: starts_at_end_of FBdv:00005334 ! embryonic stage 16 [Term] id: FBdv:00005336 name: larval stage comment: Temporal ordering number - 400. is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle relationship: starts_at_end_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005335 ! embryonic stage 17 [Term] id: FBdv:00005337 name: first instar larval stage def: "The first larval instar begins at hatching and ends at the first larval molt. Anterior spiracles are not yet present; posterior spiracles have two openings each. Salivary glands are very small and all cells are uniform in size. Mouth hooks typically have one tooth. Duration at 25 degrees C: approximately 25 hours (24-49 hours after egg laying; 0-25 hours after hatching)." [FlyBase:FBrf0007733] comment: Temporal ordering number - 410. synonym: "first instar larva" EXACT [] synonym: "L1" EXACT [] is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv:00005336 ! larval stage relationship: starts_at_end_of FBdv:00005289 ! embryonic stage relationship: starts_at_end_of FBdv:00005333 ! late embryonic stage relationship: starts_at_end_of FBdv:00005335 ! embryonic stage 17 [Term] id: FBdv:00005338 name: second instar larval stage def: "The second larval instar begins at the first larval molt and ends at the second larval molt. Larvae are actively feeding and crawling in the food. Distinct anterior spiracles are present as enlargements at the end of the tracheal trunk, but not open to the outside; posterior spiracles have three openings each, and four groups of small unbranched hairs. The salivary glands extend to the first abdominal segment, and have cells that are uniform in size. Mouth hooks typically have two or three teeth. Duration at 25 degrees C: approximately 23 hours (49-72 hours after egg laying; 25-48 hours after hatching)." [FlyBase:FBrf0007733] comment: Temporal ordering number - 420. synonym: "L2" EXACT [] synonym: "second instar larva" EXACT [] is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv:00005336 ! larval stage relationship: starts_at_end_of FBdv:00005337 ! first instar larval stage [Term] id: FBdv:00005339 name: third instar larval stage def: "The third larval instar begins at the second larval molt and ends at puparium formation. Anterior spiracles are open to the outside; posterior spiracles have three openings each, and four groups of large branched hairs. The salivary glands extend to the second abdominal segment, with cells larger in the posterior than in the anterior of the gland. Mouth hooks typically have 9-12 teeth. About 24 hours before pupariation (at 25 degree C), larvae stop feeding and climb away from their food. Duration at 25 degrees C: approximately 48 hours (72-120 hours after egg laying; 48-96 hours after hatching)." [FlyBase:FBrf0007733] comment: Temporal ordering number - 430. synonym: "L3" EXACT [] synonym: "third instar larva" RELATED [] is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv:00005336 ! larval stage relationship: starts_at_end_of FBdv:00005338 ! second instar larval stage [Term] id: FBdv:00005340 name: early third instar larval stage def: "Third instar larva prior to the wandering stage (approximately the first 24 hours of the third instar larval stage under standard conditions at 25'C.)." [FlyBase:FBrf0049147] comment: Temporal ordering number - 440. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005339 ! third instar larval stage relationship: starts_at_end_of FBdv:00005338 ! second instar larval stage created_by: david creation_date: 2008-11-13T11:51:56Z [Term] id: FBdv:00005341 name: wandering third instar larval stage def: "Stage of the third larval instar during which the larva wanders out of the food and climbs. Under optimum conditions at 25'C, this occurs approximately 24 hours after the start of the third instar larval stage." [FlyBase:FBrf0049147] comment: Temporal ordering number - 460. synonym: "late third instar" BROAD [] synonym: "post-feeding larva" BROAD [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00007007 ! late third instar larval stage relationship: starts_at_end_of FBdv:00005340 ! early third instar larval stage created_by: david creation_date: 2008-11-13T11:55:46Z [Term] id: FBdv:00005342 name: prepupal stage def: "The prepupal stage begins at puparium formation and ends when larval/pupal apolysis is complete, as indicated by the completion of imaginal head sac eversion and the expulsion of the oral armature of the larva. Duration at 25 degrees C: approximately 12 hours. (120-132.2 hours after egg laying; 0-12.2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 500. is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv:00007001 ! P-stage relationship: starts_at_end_of FBdv:00005336 ! larval stage relationship: starts_at_end_of FBdv:00005339 ! third instar larval stage relationship: starts_at_end_of FBdv:00007005 ! third instar larval stage L2 relationship: starts_at_end_of FBdv:00007007 ! late third instar larval stage [Term] id: FBdv:00005343 name: prepupal stage P1 def: "Extends from puparium formation through tanning of the pupal cuticle. Posterior spiracles and ridge between anterior spiracles tan orange. Wriggling stops completely. Puparium becomes brown to the unaided eye. Duration at 25 degrees C: approximately 20 minutes. (120-120.3 hours after egg laying; 0-0.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 510. synonym: "pupal stage P0" NARROW [FlyBase:FBrf0036849] synonym: "pupal stage P1" EXACT [] synonym: "puparium formation" EXACT [FlyBase:FBrf0036849] synonym: "white prepupa" EXACT [FlyBase:FBrf0036849] synonym: "white puparium" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005342 ! prepupal stage relationship: starts_at_end_of FBdv:00005336 ! larval stage relationship: starts_at_end_of FBdv:00005339 ! third instar larval stage relationship: starts_at_end_of FBdv:00007005 ! third instar larval stage L2 relationship: starts_at_end_of FBdv:00007007 ! late third instar larval stage [Term] id: FBdv:00005344 name: prepupal stage P2 def: "Male gonads become less distinct. Oral armature stops moving permanently. Dorsal medial abdominal contractions stop. Gas bubble becomes visible within abdomen. Duration at 25 degrees C: approximately 100 minutes. (120.3-122 hours after egg laying; 0.3-2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 520. synonym: "brown puparium" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P2" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005342 ! prepupal stage relationship: starts_at_end_of FBdv:00005343 ! prepupal stage P1 [Term] id: FBdv:00005345 name: prepupal stage P3 def: "Ridge of the operculum becomes distinct. Puparium begins to separate from underlying epidermis. Becomes positively buoyant. Duration at 25 degrees C: approximately 4 hours, 45 minutes. (122-126.75 hours after egg laying; 2-6.75 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 530. synonym: "bubble prepupa" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P3" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005342 ! prepupal stage relationship: starts_at_end_of FBdv:00005344 ! prepupal stage P2 [Term] id: FBdv:00005346 name: prepupal stage P4 def: "Prepupal stage P4 begins as the lateral trunk trachea become obscured and ends when the imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 5 hours, 30 minutes. (126.75-132.2 hours after egg laying; 6.75-12.2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 540. synonym: "cryptocephalic pupa" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P4" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005342 ! prepupal stage relationship: starts_at_end_of FBdv:00005345 ! prepupal stage P3 [Term] id: FBdv:00005347 name: prepupal stage P4(i) def: "Lateral trunk tracheae become obscured. Dorsal medial abdominal contractions occur. Everted leg and wing discs become visible. Bubble appears in posterior of puparium, displacing the pupa anteriorly; abdominal bubble disappears. Duration at 25 degrees C: approximately 5 hours, 15 minutes. (126.75-132 hours after egg laying; 6.75-12 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 550. synonym: "buoyant" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P4(i)" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005346 ! prepupal stage P4 relationship: starts_at_end_of FBdv:00005345 ! prepupal stage P3 [Term] id: FBdv:00005348 name: prepupal stage P4(ii) def: "Bubble is displaced to anterior end of the puparium, and pupa withdraws to the posterior end. Imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 12 minutes. (132-132.2 hours after egg laying; 12-12.2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 560. synonym: "moving bubble" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P4(ii)" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005346 ! prepupal stage P4 relationship: starts_at_end_of FBdv:00005347 ! prepupal stage P4(i) [Term] id: FBdv:00005349 name: pupal stage def: "The pupal stage starts once larval/pupal apolysis is complete as indicated by the expulsion of the larval armature. Early in this stage, the legs and wings reach full extension along the abdomen. The stage ends when the pupal cuticle separates from the underlying epidermis (pupal/adult apolysis), and the eye cup becomes yellow at its periphery. Duration at 25 degrees C: approximately 32 hours. (132.2-164.3 hours after egg laying; 12.2-44.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 570. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for Cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head and expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage. synonym: "phanerocephalic pupa" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv:00007001 ! P-stage relationship: starts_at_end_of FBdv:00005342 ! prepupal stage [Term] id: FBdv:00005350 name: pupal stage P5 def: "Pupal stage P5 starts when the legs and wings reach full extension along the abdomen and ends as the Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 6 hours, 30 minutes. (132.2-138.7 hours after egg laying; 12.2-18.7 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 580. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005349 ! pupal stage relationship: starts_at_end_of FBdv:00005342 ! prepupal stage relationship: starts_at_end_of FBdv:00005346 ! prepupal stage P4 relationship: starts_at_end_of FBdv:00005348 ! prepupal stage P4(ii) [Term] id: FBdv:00005351 name: pupal stage P5(i) def: "Legs and wings reach full extension along abdomen. Enlarged initial segments of anterior pair Malpighian tubules move from thorax into abdomen. Translucent patch that lacks adhering fat body cells becomes discernible in the middle of the eye region. Pair of white Malpighian tubules becomes visible dorsally in the abdomen. Duration at 25 degrees C: approximately 66 minutes. (132.2-133.3 hours after egg laying; 12.2-13.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 590. synonym: "Malpighian tubules migrating" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005350 ! pupal stage P5 relationship: starts_at_end_of FBdv:00005346 ! prepupal stage P4 relationship: starts_at_end_of FBdv:00005348 ! prepupal stage P4(ii) [Term] id: FBdv:00005352 name: pupal stage P5(ii) def: "Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 5 hours, 25 minutes. (133.3-138.7 hours after egg laying; 13.3-18.7 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 600. synonym: "white Malpighian tubules" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005350 ! pupal stage P5 relationship: starts_at_end_of FBdv:00005351 ! pupal stage P5(i) [Term] id: FBdv:00005353 name: pupal stage P6 def: "Dark green 'yellow body' appears between the anterior ends of the two Malpighian tubule segments, mid-dorsally at the anterior of the abdomen. Duration at 25 degrees C: approximately 13 hours, 45 minutes. (138.7-152.4 hours after egg laying; 18.7-32.4 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 610. synonym: "green Malpighian tubules" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005349 ! pupal stage relationship: starts_at_end_of FBdv:00005350 ! pupal stage P5 relationship: starts_at_end_of FBdv:00005352 ! pupal stage P5(ii) [Term] id: FBdv:00005354 name: pupal stage P7 def: "The 'yellow body' moves back between the Malpighian tubules. The transparent pupal cuticle separates from the underlying epidermis. Eye cup becomes yellow at its perimeter. Duration at 25 degrees C: approximately 12 hours. (152.4-164.3 hours after egg laying; 32.4-44.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 620. synonym: "yellow body" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005349 ! pupal stage relationship: starts_at_end_of FBdv:00005353 ! pupal stage P6 [Term] id: FBdv:00005355 name: pharate adult stage P8 def: "Pale yellow pigmentation spreads inwards across the eye. Eye color becomes bright yellow, then changes to amber. Duration at 25 degrees C: approximately 12 hours 20 minutes. (164.3-176.6 hours after egg laying; 44.3-56.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 630. synonym: "pupal stage P8" EXACT [] synonym: "yellow-eyed" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005349 ! pupal stage relationship: starts_at_end_of FBdv:00005354 ! pupal stage P7 [Term] id: FBdv:00005356 name: pharate adult stage P9 def: "Eye color darkens to deep amber, then becomes pale pink. Duration at 25 degrees C: approximately 18 hours. (176.6-194.5 hours after egg laying; 56.6-74.5 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 640. synonym: "amber-eyed" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P9" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005355 ! pharate adult stage P8 [Term] id: FBdv:00005357 name: pharate adult stage P10 def: "Eyes become bright red. Orbital and ocellar bristles and vibrissae darken. Duration at 25 degrees C: approximately 6 minutes. (194.5-194.6 hours after egg laying; 74.5-74.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 650. synonym: "pupal stage P10" EXACT [] synonym: "red-eye bald" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005356 ! pharate adult stage P9 [Term] id: FBdv:00005358 name: pharate adult stage P11 def: "Thoracic bristles become visible, and the tips of the wings turn grey. Duration at 25 degrees C: approximately 2 hours. (194.6-196.6 hours after egg laying; 74.6-76.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 660. synonym: "pupal stage P11" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005357 ! pharate adult stage P10 [Term] id: FBdv:00005359 name: pharate adult stage P11(i) def: "Dorsal thoracic microchaetes and macrochaetes become visible. Duration at 25 degrees C: approximately 80 minutes (194.6-195.5 hours after egg laying; 74.6-75.9 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 670. synonym: "head bristles" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P11(i)" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005358 ! pharate adult stage P11 relationship: starts_at_end_of FBdv:00005357 ! pharate adult stage P10 [Term] id: FBdv:00005360 name: pharate adult stage P11(ii) def: "Tips of folded wings become grey. Duration at 25 degrees C: approximately 45 minutes (195.5-196.6 hours after egg laying; 75.9-76.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 680. synonym: "pupal stage P11(ii)" EXACT [] synonym: "thoracic bristles" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005358 ! pharate adult stage P11 relationship: starts_at_end_of FBdv:00005359 ! pharate adult stage P11(i) [Term] id: FBdv:00005361 name: pharate adult stage P12 def: "Pharate adult stage P12 begins as the abdominal tergite bristles become visible, and ends as the wings darken to black. Duration at 25 degrees C: approximately 2 hours. (196.6-198.6 hours after egg laying; 76.6-78.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 690. synonym: "pupal stage P12" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005358 ! pharate adult stage P11 relationship: starts_at_end_of FBdv:00005360 ! pharate adult stage P11(ii) [Term] id: FBdv:00005362 name: pharate adult stage P12(i) def: "Bristles of the abdominal tergites become visible, and the wings become grey. Duration at 25 degrees C: approximately 55 minutes. (196.6-197.5 hours after egg laying; 76.6-77.5 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 700. synonym: "pupal stage P12(i)" EXACT [] synonym: "wing tips grey" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005361 ! pharate adult stage P12 relationship: starts_at_end_of FBdv:00005358 ! pharate adult stage P11 relationship: starts_at_end_of FBdv:00005360 ! pharate adult stage P11(ii) [Term] id: FBdv:00005363 name: pharate adult stage P12(ii) def: "Sex combs darken in males. Wings darken to black. Duration at 25 degrees C: approximately 65 minutes. (197.5-198.6 hours after egg laying; 77.5-78.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 710. synonym: "pupal stage P12(ii)" EXACT [] synonym: "wings grey" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005361 ! pharate adult stage P12 relationship: starts_at_end_of FBdv:00005362 ! pharate adult stage P12(i) [Term] id: FBdv:00005364 name: pharate adult stage P13 def: "Tarsal bristles darken and claws become black. Duration at 25 degrees C: approximately 3 hours, 20 minutes. (198.6-201.9 hours after egg laying; 78.6-81.9 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 720. synonym: "pupal stage P13" EXACT [] synonym: "wings black" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005361 ! pharate adult stage P12 relationship: starts_at_end_of FBdv:00005363 ! pharate adult stage P12(ii) [Term] id: FBdv:00005365 name: pharate adult stage P14 def: "The meconium appears dorsally at the posterior tip of the abdomen. Duration at 25 degrees C: approximately 9 hours, 30 minutes (201.9-211.5 hours after egg laying; 81.9-91.5 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 730. synonym: "mature bristles" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P14" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005364 ! pharate adult stage P13 [Term] id: FBdv:00005366 name: pharate adult stage P15 def: "Pharate adult stage P15 begins with the tanning of the tergites and ends with eclosion. Duration at 25 degrees C: approximately 8 hours, 30 minutes. (211.5-220 hours after egg laying; 91.5-100 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 740. synonym: "pupal stage P15" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00005365 ! pharate adult stage P14 [Term] id: FBdv:00005367 name: pharate adult stage P15(i) def: "Tanning of the tergites obscures the Malpighian tubules and the 'yellow body'. Legs begin to twitch; fly is able to walk if puparium is removed prematurely. Ptilinum expands by hydrostatic pressure, opening the operculum. Duration at 25 degrees C: approximately 8 hours, 6 minutes. (211.5-219.6 hours after egg laying; 91.5-99.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 750. synonym: "meconium" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P15(i)" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005366 ! pharate adult stage P15 relationship: starts_at_end_of FBdv:00005365 ! pharate adult stage P14 [Term] id: FBdv:00005368 name: pharate adult stage P15(ii) def: "Stage which starts when the operculum opens and ends when eclosion is completed. Duration at 25 degrees C: approximately 24 minutes. (219.6-220 hours after egg laying; 99.6-100 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355] comment: Temporal ordering number - 760. synonym: "eclosion" EXACT [FlyBase:FBrf0036849] synonym: "pupal stage P15(ii)" EXACT [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005366 ! pharate adult stage P15 relationship: starts_at_end_of FBdv:00005367 ! pharate adult stage P15(i) [Term] id: FBdv:00005369 name: adult stage comment: Temporal ordering number - 770. is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle relationship: starts_at_end_of FBdv:00005366 ! pharate adult stage P15 relationship: starts_at_end_of FBdv:00005368 ! pharate adult stage P15(ii) relationship: starts_at_end_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00007001 ! P-stage [Term] id: FBdv:00005370 name: adult stage A1 alt_id: FBdv:00005373 def: "Newly eclosed adult stage. During this stage, the wings unfold flatten and harden and the abdomen becomes broader." [FlyBase:FBrf0049147] comment: Temporal ordering number - 780. synonym: "adult stage I" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005369 ! adult stage relationship: starts_at_end_of FBdv:00005368 ! pharate adult stage P15(ii) relationship: starts_at_end_of FBdv:00006011 ! pharate adult stage relationship: starts_at_end_of FBdv:00007001 ! P-stage [Term] id: FBdv:00005371 name: adult stage A2 alt_id: FBdv:00005374 def: "Wings extended. Abdominal tergites tan to shiny brown." [FlyBase:FBrf0049147] comment: Temporal ordering number - 790. synonym: "adult stage II" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005369 ! adult stage relationship: starts_at_end_of FBdv:00005370 ! adult stage A1 [Term] id: FBdv:00005412 name: gamete comment: This should be considered as a type of cell rather than as a stage. Please use FBbt:00005412. is_obsolete: true [Term] id: FBdv:00006011 name: pharate adult stage def: "The developing adult after pupal-adult apolysis , i.e.- from stage P8 (when yellow eye color first becomes visible through the pupal case), to eclosion. Duration at 25 degrees C: approximately 55.7 hours (164.3-220 hours after egg laying; 44.3-100 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355, FlyBase:FBrf0049147] comment: Temporal ordering number - 625. is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv:00007001 ! P-stage relationship: starts_at_end_of FBdv:00005349 ! pupal stage [Term] id: FBdv:00006012 name: adult stage A3 alt_id: FBdv:00005375 def: "Tergites tanned." [FlyBase:FBrf0049147] comment: Temporal ordering number - 10310. synonym: "adult stage III" RELATED [] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005369 ! adult stage relationship: starts_at_end_of FBdv:00005371 ! adult stage A2 [Term] id: FBdv:00007000 name: spermatogenesis is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle created_by: david creation_date: 2008-06-05T04:51:08Z comment: Temporal ordering number - 800. [Term] id: FBdv:00007001 name: P-stage def: "Stage of the Drosophila life-cycle from the formation of the puparium (beginning of the prepupal stage) to eclosion." [FlyBase:DS] comment: Temporal ordering number - 490. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for Cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head an expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage. synonym: "metamorphosis" BROAD [] synonym: "pupal stage" RELATED [] is_a: FBdv:00007012 ! life cycle stage relationship: part_of FBdv_root:00000000 ! Drosophila life cycle relationship: starts_at_end_of FBdv:00005336 ! larval stage relationship: starts_at_end_of FBdv:00005339 ! third instar larval stage relationship: starts_at_end_of FBdv:00007005 ! third instar larval stage L2 relationship: starts_at_end_of FBdv:00007007 ! late third instar larval stage created_by: david creation_date: 2008-06-05T04:51:40Z [Term] id: FBdv:00007002 name: oogenesis stage S11a comment: Temporal ordering number - 10140. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005273 ! oogenesis stage S11 [Term] id: FBdv:00007003 name: oogenesis stage S11b comment: Temporal ordering number - 10150. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005273 ! oogenesis stage S11 [Term] id: FBdv:00007004 name: third instar larval stage L1 def: "Stage which begins when wandering third instar larva stops crawling. The larva everts its anterior spiracles during this stage." [FlyBase:FBrf0036849] comment: Temporal ordering number - 470. synonym: "late third-instar" BROAD [] synonym: "post-feeding larva" BROAD [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00007007 ! late third instar larval stage relationship: starts_at_end_of FBdv:00005341 ! wandering third instar larval stage [Term] id: FBdv:00007005 name: third instar larval stage L2 def: "The anterior spiracles are fully everted, with 7-9 finger-like projections. The body shortens, withdrawing three apparent abdominal segments and the larva sticks to its substrate." [FlyBase:FBrf0036849] comment: Temporal ordering number - 480. synonym: "late third instar" BROAD [] synonym: "spiracles everted larva" EXACT [FlyBase:FBrf0036849] is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00007007 ! late third instar larval stage relationship: starts_at_end_of FBdv:00007004 ! third instar larval stage L1 [Term] id: FBdv:00007006 name: oogenesis stage S13E def: "Oogenesis stage during which the number of nurse cell nuclei at the anterior of the oocyte reduce from 4 to zero. The oocyte chromosomes reach full metaphase I during this stage, at which point meiosis is arrested (until fertilization)." [FlyBase:FBrf0029744] comment: Temporal ordering number - 10250. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005278 ! oogenesis stage S13 created_by: david creation_date: 2008-11-13T06:27:57Z [Term] id: FBdv:00007007 name: late third instar larval stage def: "Third instar larva from the beginning of wandering to the beginning of puparium formation." [FBC:DOS] comment: Temporal ordering number - 450. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005339 ! third instar larval stage created_by: david creation_date: 2008-12-11T01:19:53Z [Term] id: FBdv:00007008 name: occurrent xref: span:Occurrent created_by: djs93 creation_date: 2009-10-01T05:56:28Z [Term] id: FBdv:00007009 name: developmental process xref: GO:0032502 is_a: FBdv:00007008 ! occurrent created_by: djs93 creation_date: 2009-10-01T05:56:42Z [Term] id: FBdv:00007011 name: embryonic cycle is_a: FBdv:00007009 ! developmental process created_by: djs93 creation_date: 2009-10-01T05:57:41Z [Term] id: FBdv:00007012 name: life cycle stage is_a: FBdv:00005259 ! developmental stage created_by: djs93 creation_date: 2009-10-01T05:59:22Z [Term] id: FBdv:00014201 name: early extended germ band stage def: "A collective term for stages 9 and 10." [FBC:DOS] comment: Temporal ordering number - 270. is_a: FBdv:00005259 ! developmental stage relationship: part_of FBdv:00005321 ! extended germ band stage relationship: starts_at_end_of FBdv:00005317 ! gastrula stage relationship: starts_at_end_of FBdv:00005322 ! embryonic stage 8 [Term] id: FBdv_root:00000000 name: Drosophila life cycle is_a: FBdv:00007008 ! occurrent [Typedef] id: part_of name: part_of xref: OBO_REL:part_of is_transitive: true [Typedef] id: preceded_by name: preceded_by xref: OBO_REL:preceded_by is_transitive: true created_by: djs93 creation_date: 2009-10-09T10:00:53Z [Typedef] id: starts_at_end_of name: starts_at_end_of is_a: preceded_by ! preceded_by