format-version: 1.2 data-version: 2013-04-20 date: 19:04:2013 15:14 saved-by: dph auto-generated-by: OBO-Edit 2.3-beta5 subsetdef: Cross_product_review "Involved_in" subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: mf_needs_review "Catalytic activity terms in need of attention" subsetdef: termgenie_unvetted "Terms created by TermGenie that do not follow a template and require additional vetting by editors" subsetdef: virus_checked "Viral overhaul terms" synonymtypedef: systematic_synonym "Systematic synonym" EXACT default-namespace: gene_ontology remark: cvs version: use data-version ontology: go [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000005 name: ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0042254 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0000006 name: high affinity zinc uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000008 name: thioredoxin namespace: molecular_function alt_id: GO:0000013 def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0003756 consider: GO:0015036 [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248] synonym: "1,6-alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.- xref: Reactome:REACT_22295 "Addition of a third mannose to the N-glycan precursor by Alg2, Saccharomyces cerevisiae" xref: Reactome:REACT_22383 "Addition of a third mannose to the N-glycan precursor by ALG2, Homo sapiens" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [EC:2.5.1.30, RHEA:20839] subset: gosubset_prok synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] xref: EC:2.5.1.30 xref: KEGG:R05612 xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN xref: RHEA:20839 xref: RHEA:27797 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA specific endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] synonym: "ssDNA-specific endodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "enolase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] xref: EC:3.2.1.108 xref: MetaCyc:LACTASE-RXN xref: Reactome:REACT_100439 "lactose + H2O => D-glucose + D-galactose, Gallus gallus" xref: Reactome:REACT_104113 "lactose + H2O => D-glucose + D-galactose, Rattus norvegicus" xref: Reactome:REACT_105850 "lactose + H2O => D-glucose + D-galactose, Bos taurus" xref: Reactome:REACT_109208 "lactose + H2O => D-glucose + D-galactose, Taeniopygia guttata" xref: Reactome:REACT_109391 "lactose + H2O => D-glucose + D-galactose, Sus scrofa" xref: Reactome:REACT_109447 "lactose + H2O => D-glucose + D-galactose, Danio rerio" xref: Reactome:REACT_112431 "lactose + H2O => D-glucose + D-galactose, Caenorhabditis elegans" xref: Reactome:REACT_114967 "lactose + H2O => D-glucose + D-galactose, Drosophila melanogaster" xref: Reactome:REACT_30821 "lactose + H2O => D-glucose + D-galactose, Mus musculus" xref: Reactome:REACT_78084 "lactose + H2O => D-glucose + D-galactose, Canis familiaris" xref: Reactome:REACT_78754 "lactose + H2O => D-glucose + D-galactose, Xenopus tropicalis" xref: Reactome:REACT_9455 "lactose + H2O => D-glucose + D-galactose, Homo sapiens" xref: RHEA:10079 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination relationship: regulates GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it describes a substrate-specific process. is_obsolete: true consider: GO:0045950 [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation relationship: part_of GO:0007052 ! mitotic spindle organization [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "malt sugar metabolic process" EXACT [] synonym: "malt sugar metabolism" EXACT [] synonym: "maltose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0000024 name: maltose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "malt sugar biosynthesis" EXACT [] synonym: "malt sugar biosynthetic process" EXACT [] synonym: "maltose anabolism" EXACT [] synonym: "maltose biosynthesis" EXACT [] synonym: "maltose formation" EXACT [] synonym: "maltose synthesis" EXACT [] is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0000025 name: maltose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "malt sugar catabolic process" EXACT [] synonym: "malt sugar catabolism" EXACT [] synonym: "maltose breakdown" EXACT [] synonym: "maltose degradation" EXACT [] synonym: "maltose hydrolysis" NARROW [] xref: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- xref: Reactome:REACT_22123 "Addition of the seventh mannose to the N-glycan precursor by ALG9, inside the ER lumen, Homo sapiens" xref: Reactome:REACT_22156 "Addition of a fourth and fifth mannose to the N-glycan precursor by ALG11, Homo sapiens" xref: Reactome:REACT_22220 "Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11, Saccharomyces cerevisiae" xref: Reactome:REACT_22307 "Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen., Homo sapiens" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] subset: gosubset_prok synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000028 name: ribosomal small subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl] subset: gosubset_prok synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- xref: Reactome:REACT_1018 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Homo sapiens" xref: Reactome:REACT_105204 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Dictyostelium discoideum" xref: Reactome:REACT_2179 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Homo sapiens" xref: Reactome:REACT_22117 "Addition of the eighth mannose to the N-glycan precursor by ALG12, inside the ER lumen, Homo sapiens" xref: Reactome:REACT_30252 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Rattus norvegicus" xref: Reactome:REACT_34702 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Danio rerio" xref: Reactome:REACT_63412 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Mus musculus" xref: Reactome:REACT_87972 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Canis familiaris" xref: Reactome:REACT_95740 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Gallus gallus" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai] subset: gosubset_prok synonym: "cell wall mannoprotein anabolism" EXACT [] synonym: "cell wall mannoprotein biosynthesis" EXACT [] synonym: "cell wall mannoprotein formation" EXACT [] synonym: "cell wall mannoprotein synthesis" EXACT [] is_a: GO:0006057 ! mannoprotein biosynthetic process is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- xref: Reactome:REACT_22347 "Addition of a second mannose to the N-glycan precursor by ALG2, Homo sapiens" xref: Reactome:REACT_22415 "Addition of the sixth mannose to the N-glycan precursor by ALG3., Homo sapiens" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] subset: gosubset_prok synonym: "ADase activity" EXACT [EC:3.5.4.2] synonym: "adenase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] xref: EC:3.5.4.2 xref: MetaCyc:ADENINE-DEAMINASE-RXN xref: RHEA:23691 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process namespace: molecular_function def: "Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl, GOC:vw] comment: Note that this term was moved from transporter to binding because we decided that ACP is not a true transporter, but instead tethers the growing entity that is acted on to make the fatty acid, so binding is the more correct parent. July 2012. subset: gosubset_prok synonym: "acyl carrier activity" EXACT [] is_a: GO:0044620 ! ACP phosphopantetheine attachment site binding [Term] id: GO:0000038 name: very long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:hjd] subset: gosubset_prok synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf] synonym: "very-long-chain fatty acid metabolic process" EXACT [] synonym: "very-long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0000039 name: plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. is_obsolete: true consider: GO:0005324 consider: GO:0005886 [Term] id: GO:0000040 name: low-affinity iron ion transport namespace: biological_process def: "The directed, low-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] synonym: "low affinity iron ion transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] subset: gosubset_prok synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000042 name: protein targeting to Golgi namespace: biological_process def: "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah] synonym: "protein-Golgi targeting" EXACT [] is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi is_a: GO:0006605 ! protein targeting is_a: GO:0016482 ! cytoplasmic transport is_a: GO:0072600 ! establishment of protein localization to Golgi [Term] id: GO:0000044 name: ascorbate stabilization namespace: biological_process def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "vitamin C stabilization" EXACT [] is_obsolete: true [Term] id: GO:0000045 name: autophagic vacuole assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0007033 ! vacuole organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000046 name: autophagic vacuole fusion namespace: biological_process def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole." [PMID:11099404] synonym: "amphisome-lysosome fusion" NARROW [] synonym: "autolysosome formation" NARROW [] synonym: "fusion of autophagosome with lysosome" NARROW [] is_a: GO:0048284 ! organelle fusion is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000047 name: Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "Rieske iron-sulphur protein" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] xref: EC:2.3.2.12 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: Reactome:REACT_102632 "Peptide transfer from P-site tRNA to the A-site tRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_104123 "Peptide transfer from P-site tRNA to the A-site tRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_112282 "Peptide transfer from P-site tRNA to the A-site tRNA, Gallus gallus" xref: Reactome:REACT_115501 "Peptide transfer from P-site tRNA to the A-site tRNA, Rattus norvegicus" xref: Reactome:REACT_1227 "Peptide transfer from P-site tRNA to the A-site tRNA, Homo sapiens" xref: Reactome:REACT_28090 "Peptide transfer from P-site tRNA to the A-site tRNA, Arabidopsis thaliana" xref: Reactome:REACT_31656 "Peptide transfer from P-site tRNA to the A-site tRNA, Taeniopygia guttata" xref: Reactome:REACT_33679 "Peptide transfer from P-site tRNA to the A-site tRNA, Dictyostelium discoideum" xref: Reactome:REACT_77497 "Peptide transfer from P-site tRNA to the A-site tRNA, Oryza sativa" xref: Reactome:REACT_81539 "Peptide transfer from P-site tRNA to the A-site tRNA, Drosophila melanogaster" xref: Reactome:REACT_87719 "Peptide transfer from P-site tRNA to the A-site tRNA, Mus musculus" xref: Reactome:REACT_90185 "Peptide transfer from P-site tRNA to the A-site tRNA, Danio rerio" xref: Reactome:REACT_90457 "Peptide transfer from P-site tRNA to the A-site tRNA, Canis familiaris" xref: Reactome:REACT_91228 "Peptide transfer from P-site tRNA to the A-site tRNA, Caenorhabditis elegans" xref: Reactome:REACT_95405 "Peptide transfer from P-site tRNA to the A-site tRNA, Plasmodium falciparum" xref: Reactome:REACT_98179 "Peptide transfer from P-site tRNA to the A-site tRNA, Xenopus tropicalis" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle namespace: biological_process alt_id: GO:0006594 alt_id: GO:0006871 def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732] synonym: "ornithine cycle" EXACT [] synonym: "urea biosynthesis" EXACT [] synonym: "urea biosynthetic process" EXACT [] xref: Reactome:REACT_100599 "Urea cycle, Oryza sativa" xref: Reactome:REACT_107747 "Urea cycle, Mus musculus" xref: Reactome:REACT_109525 "Urea cycle, Danio rerio" xref: Reactome:REACT_31787 "Urea cycle, Taeniopygia guttata" xref: Reactome:REACT_32463 "Urea cycle, Drosophila melanogaster" xref: Reactome:REACT_32971 "Urea cycle, Caenorhabditis elegans" xref: Reactome:REACT_33119 "Urea cycle, Bos taurus" xref: Reactome:REACT_78616 "Urea cycle, Plasmodium falciparum" xref: Reactome:REACT_80089 "Urea cycle, Canis familiaris" xref: Reactome:REACT_81058 "Urea cycle, Dictyostelium discoideum" xref: Reactome:REACT_82995 "Urea cycle, Mycobacterium tuberculosis" xref: Reactome:REACT_83831 "Urea cycle, Rattus norvegicus" xref: Reactome:REACT_84694 "Urea cycle, Saccharomyces cerevisiae" xref: Reactome:REACT_847 "Urea cycle, Homo sapiens" xref: Reactome:REACT_88394 "Urea cycle, Gallus gallus" xref: Reactome:REACT_90218 "Urea cycle, Escherichia coli" xref: Reactome:REACT_90565 "Urea cycle, Sus scrofa" xref: Reactome:REACT_92378 "Urea cycle, Xenopus tropicalis" xref: Reactome:REACT_95880 "Urea cycle, Staphylococcus aureus N315" xref: Reactome:REACT_97366 "Urea cycle, Arabidopsis thaliana" xref: Reactome:REACT_98985 "Urea cycle, Schizosaccharomyces pombe" xref: Wikipedia:Urea_cycle is_a: GO:0019627 ! urea metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0000051 name: urea cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. subset: gosubset_prok synonym: "urea cycle intermediate metabolism" EXACT [] is_obsolete: true [Term] id: GO:0000052 name: citrulline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] subset: gosubset_prok synonym: "citrulline metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0000053 name: argininosuccinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732] synonym: "argininosuccinate metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0000054 name: ribosomal subunit export from nucleus namespace: biological_process def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai] subset: goslim_yeast synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah] synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb] is_a: GO:0033753 ! establishment of ribosome localization is_a: GO:0051168 ! nuclear export is_a: GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0000055 name: ribosomal large subunit export from nucleus namespace: biological_process alt_id: GO:0000057 def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal large subunit export from cell nucleus" EXACT [] synonym: "ribosomal large subunit export out of nucleus" EXACT [] synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal large subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000056 name: ribosomal small subunit export from nucleus namespace: biological_process alt_id: GO:0000058 def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal small subunit export from cell nucleus" EXACT [] synonym: "ribosomal small subunit export out of nucleus" EXACT [] synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal small subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000059 name: protein import into nucleus, docking namespace: biological_process def: "A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736] synonym: "protein docking during protein import into nucleus" EXACT [] synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein docking during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] synonym: "protein-nucleus import, docking" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000060 name: protein import into nucleus, translocation namespace: biological_process def: "A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736] comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "protein import into cell nucleus, translocation" EXACT [] synonym: "protein translocation during protein import into nucleus" EXACT [] synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein translocation during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] synonym: "protein-nucleus import, translocation" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0044765 ! single-organism transport relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000061 name: protein import into nucleus, substrate release namespace: biological_process def: "A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515] synonym: "protein import into cell nucleus, substrate release" EXACT [] synonym: "protein substrate release during protein import into nucleus" EXACT [] synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein substrate release during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] synonym: "protein-nucleus import, substrate release" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000062 name: fatty-acyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0000064 name: L-ornithine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "L-ornithine transporter activity" BROAD [] xref: Reactome:REACT_100602 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Mus musculus" xref: Reactome:REACT_102399 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Xenopus tropicalis" xref: Reactome:REACT_103552 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Gallus gallus" xref: Reactome:REACT_103610 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Canis familiaris" xref: Reactome:REACT_104169 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Sus scrofa" xref: Reactome:REACT_109285 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Caenorhabditis elegans" xref: Reactome:REACT_115531 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Gallus gallus" xref: Reactome:REACT_151 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Homo sapiens" xref: Reactome:REACT_28177 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Drosophila melanogaster" xref: Reactome:REACT_30708 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Arabidopsis thaliana" xref: Reactome:REACT_78308 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Dictyostelium discoideum" xref: Reactome:REACT_84383 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Oryza sativa" xref: Reactome:REACT_88886 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Danio rerio" xref: Reactome:REACT_88959 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Rattus norvegicus" xref: Reactome:REACT_90007 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Taeniopygia guttata" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0000066 name: mitochondrial ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015822 ! ornithine transport [Term] id: GO:0000067 name: DNA replication and chromosome cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. is_obsolete: true consider: GO:0006260 consider: GO:0007059 consider: GO:0051276 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai] synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000072 name: M phase specific microtubule process namespace: biological_process def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] synonym: "M-phase specific microtubule process" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000279 ! M phase [Term] id: GO:0000073 name: spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051300 ! spindle pole body organization [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process alt_id: GO:0031576 alt_id: GO:0071779 def: "A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] comment: Note that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. subset: gocheck_do_not_manually_annotate synonym: "G1/S checkpoint" EXACT [] synonym: "G1/S transition checkpoint" EXACT [] synonym: "G2/M checkpoint" EXACT [] synonym: "G2/M transition checkpoint" EXACT [] xref: Reactome:REACT_100401 "Cell Cycle Checkpoints, Gallus gallus" xref: Reactome:REACT_102145 "Cell Cycle Checkpoints, Saccharomyces cerevisiae" xref: Reactome:REACT_102175 "Cell Cycle Checkpoints, Canis familiaris" xref: Reactome:REACT_106487 "Cell Cycle Checkpoints, Rattus norvegicus" xref: Reactome:REACT_109101 "Cell Cycle Checkpoints, Drosophila melanogaster" xref: Reactome:REACT_1538 "Cell Cycle Checkpoints, Homo sapiens" xref: Reactome:REACT_29957 "Cell Cycle Checkpoints, Bos taurus" xref: Reactome:REACT_31789 "Cell Cycle Checkpoints, Dictyostelium discoideum" xref: Reactome:REACT_33305 "Cell Cycle Checkpoints, Oryza sativa" xref: Reactome:REACT_79078 "Cell Cycle Checkpoints, Sus scrofa" xref: Reactome:REACT_84460 "Cell Cycle Checkpoints, Arabidopsis thaliana" xref: Reactome:REACT_89660 "Cell Cycle Checkpoints, Xenopus tropicalis" xref: Reactome:REACT_90285 "Cell Cycle Checkpoints, Mus musculus" xref: Reactome:REACT_90465 "Cell Cycle Checkpoints, Caenorhabditis elegans" xref: Reactome:REACT_92239 "Cell Cycle Checkpoints, Danio rerio" xref: Reactome:REACT_96499 "Cell Cycle Checkpoints, Taeniopygia guttata" xref: Reactome:REACT_99737 "Cell Cycle Checkpoints, Schizosaccharomyces pombe" xref: Wikipedia:Cell_cycle_checkpoint is_a: GO:0022402 ! cell cycle process [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: Wikipedia:DNA_damage_checkpoint xref: Wikipedia:Postreplication_checkpoint is_a: GO:0006974 ! response to DNA damage stimulus is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000078 name: cell shape checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis." [GOC:mtg_cell_cycle] comment: **Check this term. synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw] is_a: GO:0007093 ! mitotic cell cycle checkpoint [Term] id: GO:0000079 name: regulation of cyclin-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] synonym: "regulation of CDK activity" EXACT [] synonym: "regulation of cyclin-dependent protein kinase activity" BROAD [] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity [Term] id: GO:0000080 name: G1 phase of mitotic cell cycle namespace: biological_process def: "G1 phase occurring as part of the mitotic cell cycle. G1 phase is the interval between the completion of DNA segregation (mitosis in a mitotic cell cycle) and the beginning of DNA synthesis. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] subset: gocheck_do_not_annotate xref: Reactome:REACT_101162 "G1 Phase, Bos taurus" xref: Reactome:REACT_1590 "G1 Phase, Homo sapiens" xref: Reactome:REACT_29795 "G1 Phase, Taeniopygia guttata" xref: Reactome:REACT_34060 "G1 Phase, Canis familiaris" xref: Reactome:REACT_78665 "G1 Phase, Gallus gallus" xref: Reactome:REACT_78866 "G1 Phase, Sus scrofa" xref: Reactome:REACT_83686 "G1 Phase, Danio rerio" xref: Reactome:REACT_91654 "G1 Phase, Mus musculus" xref: Reactome:REACT_93384 "G1 Phase, Rattus norvegicus" xref: Reactome:REACT_93574 "G1 Phase, Xenopus tropicalis" is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] xref: Reactome:REACT_101799 "G1/S Transition, Taeniopygia guttata" xref: Reactome:REACT_102687 "G1/S Transition, Arabidopsis thaliana" xref: Reactome:REACT_104020 "G1/S Transition, Canis familiaris" xref: Reactome:REACT_104529 "G1/S Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_104577 "G1/S Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_106054 "G1/S Transition, Mus musculus" xref: Reactome:REACT_107492 "G1/S Transition, Dictyostelium discoideum" xref: Reactome:REACT_109784 "G1/S Transition, Oryza sativa" xref: Reactome:REACT_109821 "G1/S Transition, Danio rerio" xref: Reactome:REACT_110917 "G1/S Transition, Plasmodium falciparum" xref: Reactome:REACT_1783 "G1/S Transition, Homo sapiens" xref: Reactome:REACT_28713 "G1/S Transition, Xenopus tropicalis" xref: Reactome:REACT_45711 "G1/S Transition, Caenorhabditis elegans" xref: Reactome:REACT_84226 "G1/S Transition, Gallus gallus" xref: Reactome:REACT_85355 "G1/S Transition, Sus scrofa" xref: Reactome:REACT_87037 "G1/S Transition, Drosophila melanogaster" xref: Reactome:REACT_88046 "G1/S Transition, Bos taurus" xref: Reactome:REACT_95294 "G1/S Transition, Rattus norvegicus" is_a: GO:0044772 ! mitotic cell cycle phase transition relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000083 name: regulation of transcription involved in G1/S phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1/S-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in G1/S-phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_683 "G1/S-Specific Transcription, Homo sapiens" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: S phase of mitotic cell cycle namespace: biological_process def: "S phase occurring as part of the mitotic cell cycle. S phase is the part of the cell cycle during which DNA synthesis takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "S-phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_105829 "S Phase, Caenorhabditis elegans" xref: Reactome:REACT_108550 "S Phase, Rattus norvegicus" xref: Reactome:REACT_110039 "S Phase, Schizosaccharomyces pombe" xref: Reactome:REACT_28988 "S Phase, Taeniopygia guttata" xref: Reactome:REACT_32013 "S Phase, Mycobacterium tuberculosis" xref: Reactome:REACT_34043 "S Phase, Oryza sativa" xref: Reactome:REACT_78838 "S Phase, Plasmodium falciparum" xref: Reactome:REACT_78845 "S Phase, Xenopus tropicalis" xref: Reactome:REACT_81914 "S Phase, Saccharomyces cerevisiae" xref: Reactome:REACT_82813 "S Phase, Arabidopsis thaliana" xref: Reactome:REACT_85811 "S Phase, Sus scrofa" xref: Reactome:REACT_89318 "S Phase, Drosophila melanogaster" xref: Reactome:REACT_899 "S Phase, Homo sapiens" xref: Reactome:REACT_92500 "S Phase, Mus musculus" xref: Reactome:REACT_92759 "S Phase, Canis familiaris" xref: Reactome:REACT_95174 "S Phase, Gallus gallus" xref: Reactome:REACT_96081 "S Phase, Dictyostelium discoideum" xref: Reactome:REACT_97603 "S Phase, Danio rerio" xref: Reactome:REACT_99645 "S Phase, Bos taurus" is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000085 name: G2 phase of mitotic cell cycle namespace: biological_process def: "G2 phase occurring as part of the mitotic cell cycle. G2 phase is the interval between the completion of DNA synthesis and the beginning of DNA segregation (mitosis in a mitotic cell cycle). A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:REACT_105223 "G2 Phase, Mus musculus" xref: Reactome:REACT_105307 "G2 Phase, Canis familiaris" xref: Reactome:REACT_106415 "G2 Phase, Xenopus tropicalis" xref: Reactome:REACT_106836 "G2 Phase, Bos taurus" xref: Reactome:REACT_1915 "G2 Phase, Homo sapiens" xref: Reactome:REACT_28975 "G2 Phase, Rattus norvegicus" xref: Reactome:REACT_85928 "G2 Phase, Sus scrofa" xref: Reactome:REACT_96332 "G2 Phase, Danio rerio" is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] xref: Reactome:REACT_100942 "G2/M Transition, Danio rerio" xref: Reactome:REACT_103766 "G2/M Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_107882 "G2/M Transition, Sus scrofa" xref: Reactome:REACT_114616 "G2/M Transition, Arabidopsis thaliana" xref: Reactome:REACT_2203 "G2/M Transition, Homo sapiens" xref: Reactome:REACT_28929 "G2/M Transition, Xenopus tropicalis" xref: Reactome:REACT_30388 "G2/M Transition, Gallus gallus" xref: Reactome:REACT_34062 "G2/M Transition, Mus musculus" xref: Reactome:REACT_77778 "G2/M Transition, Taeniopygia guttata" xref: Reactome:REACT_83880 "G2/M Transition, Drosophila melanogaster" xref: Reactome:REACT_87036 "G2/M Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_87230 "G2/M Transition, Canis familiaris" xref: Reactome:REACT_87807 "G2/M Transition, Dictyostelium discoideum" xref: Reactome:REACT_88018 "G2/M Transition, Caenorhabditis elegans" xref: Reactome:REACT_88369 "G2/M Transition, Rattus norvegicus" xref: Reactome:REACT_92702 "G2/M Transition, Bos taurus" is_a: GO:0044772 ! mitotic cell cycle phase transition [Term] id: GO:0000087 name: M phase of mitotic cell cycle namespace: biological_process def: "M phase occurring as part of the mitotic cell cycle. M phase is the part of the cell cycle during which nuclear division takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "M-phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_105412 "M Phase, Mus musculus" xref: Reactome:REACT_107095 "M Phase, Dictyostelium discoideum" xref: Reactome:REACT_109059 "M Phase, Saccharomyces cerevisiae" xref: Reactome:REACT_29488 "M Phase, Canis familiaris" xref: Reactome:REACT_33490 "M Phase, Caenorhabditis elegans" xref: Reactome:REACT_82055 "M Phase, Rattus norvegicus" xref: Reactome:REACT_87132 "M Phase, Bos taurus" xref: Reactome:REACT_88263 "M Phase, Xenopus tropicalis" xref: Reactome:REACT_910 "M Phase, Homo sapiens" xref: Reactome:REACT_92998 "M Phase, Danio rerio" xref: Reactome:REACT_93131 "M Phase, Schizosaccharomyces pombe" xref: Reactome:REACT_93566 "M Phase, Gallus gallus" xref: Reactome:REACT_93720 "M Phase, Drosophila melanogaster" xref: Reactome:REACT_94536 "M Phase, Taeniopygia guttata" is_a: GO:0000279 ! M phase relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "Prophase occurring as part of mitosis. Prophase is the part of nuclear division in which, canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:REACT_100605 "Mitotic Prophase, Saccharomyces cerevisiae" xref: Reactome:REACT_102122 "Mitotic Prophase, Mus musculus" xref: Reactome:REACT_105127 "Mitotic Prophase, Danio rerio" xref: Reactome:REACT_106058 "Mitotic Prophase, Drosophila melanogaster" xref: Reactome:REACT_28443 "Mitotic Prophase, Taeniopygia guttata" xref: Reactome:REACT_28607 "Mitotic Prophase, Rattus norvegicus" xref: Reactome:REACT_32677 "Mitotic Prophase, Xenopus tropicalis" xref: Reactome:REACT_765 "Mitotic Prophase, Homo sapiens" xref: Reactome:REACT_79474 "Mitotic Prophase, Caenorhabditis elegans" xref: Reactome:REACT_80300 "Mitotic Prophase, Gallus gallus" xref: Reactome:REACT_83888 "Mitotic Prophase, Dictyostelium discoideum" xref: Reactome:REACT_90347 "Mitotic Prophase, Canis familiaris" xref: Reactome:REACT_90481 "Mitotic Prophase, Schizosaccharomyces pombe" is_a: GO:0051324 ! prophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "Metaphase occurring as part of mitosis. Metaphase is the part of nuclear division in which, canonically, chromosomes become aligned on the equatorial plate of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0815316194] xref: Reactome:REACT_434 "Mitotic Metaphase, Homo sapiens" is_a: GO:0051323 ! metaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "Anaphase occurring as part of mitosis. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, ISBN:0815316194] subset: gocheck_do_not_annotate xref: Reactome:REACT_1275 "Mitotic Anaphase, Homo sapiens" is_a: GO:0051322 ! anaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [GOC:dph, GOC:mah, ISBN:0815316194] subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GOC:dph, GOC:mah, ISBN:0815316194] subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "Telophase occurring as part of mitosis. Telophase is the part of nuclear division that, canonically, begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:mah, ISBN:0721662544] is_a: GO:0051326 ! telophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000094 name: septin assembly and septum formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. is_obsolete: true consider: GO:0000917 consider: GO:0000918 consider: GO:0000921 [Term] id: GO:0000095 name: S-adenosyl-L-methionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015177 def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine permease activity" EXACT [] synonym: "S-adenosyl methionine transporter activity" EXACT [] synonym: "S-adenosylmethionine permease activity" EXACT [] synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] synonym: "SAM transmembrane transporter activity" EXACT [] is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity is_a: GO:0051185 ! coenzyme transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid metabolism" EXACT [] synonym: "sulphur amino acid metabolic process" EXACT [] synonym: "sulphur amino acid metabolism" EXACT [] xref: Reactome:REACT_115639 "Sulfur amino acid metabolism, Homo sapiens" xref: Reactome:REACT_118084 "Sulfur amino acid metabolism, Rattus norvegicus" xref: Reactome:REACT_118094 "Sulfur amino acid metabolism, Bos taurus" xref: Reactome:REACT_118099 "Sulfur amino acid metabolism, Escherichia coli" xref: Reactome:REACT_118166 "Sulfur amino acid metabolism, Taeniopygia guttata" xref: Reactome:REACT_118184 "Sulfur amino acid metabolism, Canis familiaris" xref: Reactome:REACT_118203 "Sulfur amino acid metabolism, Sus scrofa" xref: Reactome:REACT_118227 "Sulfur amino acid metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_118256 "Sulfur amino acid metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_118291 "Sulfur amino acid metabolism, Caenorhabditis elegans" xref: Reactome:REACT_118309 "Sulfur amino acid metabolism, Gallus gallus" xref: Reactome:REACT_118314 "Sulfur amino acid metabolism, Arabidopsis thaliana" xref: Reactome:REACT_118323 "Sulfur amino acid metabolism, Xenopus tropicalis" xref: Reactome:REACT_118328 "Sulfur amino acid metabolism, Drosophila melanogaster" xref: Reactome:REACT_118349 "Sulfur amino acid metabolism, Oryza sativa" xref: Reactome:REACT_118370 "Sulfur amino acid metabolism, Mus musculus" xref: Reactome:REACT_118388 "Sulfur amino acid metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_118463 "Sulfur amino acid metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_118518 "Sulfur amino acid metabolism, Dictyostelium discoideum" xref: Reactome:REACT_118541 "Sulfur amino acid metabolism, Danio rerio" xref: Reactome:REACT_27187 "Sulfur amino acid metabolism, Mycobacterium tuberculosis" is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid anabolism" EXACT [] synonym: "sulfur amino acid biosynthesis" EXACT [] synonym: "sulfur amino acid formation" EXACT [] synonym: "sulfur amino acid synthesis" EXACT [] synonym: "sulphur amino acid biosynthesis" EXACT [] synonym: "sulphur amino acid biosynthetic process" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000098 name: sulfur amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid breakdown" EXACT [] synonym: "sulfur amino acid catabolism" EXACT [] synonym: "sulfur amino acid degradation" EXACT [] synonym: "sulphur amino acid catabolic process" EXACT [] synonym: "sulphur amino acid catabolism" EXACT [] xref: Reactome:REACT_115654 "Degradation of cysteine and homocysteine, Homo sapiens" is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0000099 name: sulfur amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sulfur amino acid transporter activity" BROAD [] synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] synonym: "sulphur amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000100 name: S-methylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015178 def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "S-methylmethionine permease activity" EXACT [] synonym: "S-methylmethionine transporter activity" BROAD [] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "sulphur amino acid transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000102 name: L-methionine secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "L-methionine porter activity" RELATED [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015191 ! L-methionine transmembrane transporter activity is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process alt_id: GO:0019378 def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] subset: gosubset_prok synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [] synonym: "sulphate assimilation" EXACT [] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [] xref: Reactome:REACT_27155 "Sulfate assimilation, Mycobacterium tuberculosis" is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd] subset: gosubset_prok synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] xref: EC:1.3.99.1 xref: MetaCyc:SUCC-FUM-OXRED-RXN xref: RHEA:16360 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine anabolism" EXACT [] synonym: "histidine biosynthesis" EXACT [] synonym: "histidine formation" EXACT [] synonym: "histidine synthesis" EXACT [] xref: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009076 ! histidine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0000107 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN] subset: gosubset_prok synonym: "glutamine amidotransferase:cyclase activity" BROAD [] synonym: "imidazole glycerol phosphate synthase activity" EXACT [] synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] xref: EC:2.4.2.- xref: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: repairosome namespace: cellular_component def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators. is_obsolete: true replaced_by: GO:0000109 [Term] id: GO:0000109 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000110 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" EXACT [] synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000111 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000112 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000113 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000114 name: regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0000115 name: regulation of transcription involved in S phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] synonym: "S-specific transcription in mitotic cell cycle" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0000116 name: regulation of transcription involved in G2-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle [Term] id: GO:0000117 name: regulation of transcription involved in G2/M-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. synonym: "HDAC complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah] is_a: GO:0005667 ! transcription factor complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] xref: EC:3.1.3.21 xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN xref: RHEA:11479 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0000122 name: negative regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "PCAF histone acetylase-associated complex" EXACT [] synonym: "SPT3-TAF9-PCAF acetylase complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The reversible, calcium-dependent non-sexual aggregation of single-celled organisms." [GOC:jl, GOC:vw] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Flocculation is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0000131 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] is_a: GO:0044424 ! intracellular part [Term] id: GO:0000132 name: establishment of mitotic spindle orientation namespace: biological_process alt_id: GO:0030607 alt_id: GO:0030609 def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "mitotic spindle orientation" EXACT [] synonym: "orienting of mitotic spindle" EXACT [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030427 ! site of polarized growth [Term] id: GO:0000135 name: septin checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642] comment: Is this equivalent to GO:0031565? is_a: GO:0031565 ! cytokinesis checkpoint [Term] id: GO:0000136 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825] is_a: GO:0030173 ! integral to Golgi membrane is_a: GO:0031501 ! mannosyltransferase complex relationship: part_of GO:0000137 ! Golgi cis cisterna [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] synonym: "late Golgi" RELATED [GOC:mah] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+)." [EC:1.1.1.101] synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref: Reactome:REACT_759 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+, Homo sapiens" xref: RHEA:17344 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555] synonym: "neck ring" EXACT [] is_a: GO:0005826 ! actomyosin contractile ring relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000144 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] synonym: "Sec6/8 complex" EXACT [] xref: Wikipedia:Exocyst is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus" is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030866 ! cortical actin cytoskeleton organization [Term] id: GO:0000148 name: 1,3-beta-D-glucan synthase complex namespace: cellular_component def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [EC:2.4.1.34] synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb] synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] synonym: "SNAP receptor binding" EXACT [] xref: Reactome:REACT_100180 "Acetylcholine synaptic vesicle docking and priming, Rattus norvegicus" xref: Reactome:REACT_101078 "Noradrenalin synaptic vesicle docking and priming, Canis familiaris" xref: Reactome:REACT_103740 "Acetylcholine synaptic vesicle docking and priming, Canis familiaris" xref: Reactome:REACT_105540 "Vamp7 associated Lysosome to Plasma membrane transport, Mus musculus" xref: Reactome:REACT_106347 "release of L-Glutamate at the synapse, Canis familiaris" xref: Reactome:REACT_107235 "Vamp2 associated secretory vesicle to plasma membrane transport, Dictyostelium discoideum" xref: Reactome:REACT_107965 "Noradrenalin synaptic vesicle docking and priming, Mus musculus" xref: Reactome:REACT_109894 "Vamp7 associated Lysosome to Plasma membrane transport, Dictyostelium discoideum" xref: Reactome:REACT_110250 "Vamp2 associated secretory vesicle to plasma membrane transport, Canis familiaris" xref: Reactome:REACT_110371 "Release of noradrenaline at the synapse, Rattus norvegicus" xref: Reactome:REACT_110396 "Vamp7 associated Lysosome to Plasma membrane transport, Xenopus tropicalis" xref: Reactome:REACT_112169 "Acetylcholine synaptic vesicle docking and priming, Caenorhabditis elegans" xref: Reactome:REACT_112728 "Release of noradrenaline at the synapse, Caenorhabditis elegans" xref: Reactome:REACT_113606 "Glutamate synaptic vesicle docking and priming, Caenorhabditis elegans" xref: Reactome:REACT_113753 "Exocytosis of Insulin, Danio rerio" xref: Reactome:REACT_114225 "Noradrenalin synaptic vesicle docking and priming, Gallus gallus" xref: Reactome:REACT_114547 "Noradrenalin synaptic vesicle docking and priming, Caenorhabditis elegans" xref: Reactome:REACT_115054 "release of L-Glutamate at the synapse, Xenopus tropicalis" xref: Reactome:REACT_115130 "Acetylcholine synaptic vesicle docking and priming, Gallus gallus" xref: Reactome:REACT_115353 "Release of acetylcholine at the synapse, Xenopus tropicalis" xref: Reactome:REACT_12411 "release of L-Glutamate at the synapse, Homo sapiens" xref: Reactome:REACT_12617 "Glutamate synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_14778 "Vamp7 associated Lysosome to Plasma membrane transport, Homo sapiens" xref: Reactome:REACT_14821 "Vamp8 associated secretory vesicle to plasma membrane transport, Homo sapiens" xref: Reactome:REACT_14822 "Vamp2 associated secretory vesicle to plasma membrane transport, Homo sapiens" xref: Reactome:REACT_15326 "Exocytosis of Insulin, Homo sapiens" xref: Reactome:REACT_15338 "Serotonin loaded synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15404 "Release of acetylcholine at the synapse, Homo sapiens" xref: Reactome:REACT_15411 "Noradrenalin synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15448 "Release of noradrenaline at the synapse, Homo sapiens" xref: Reactome:REACT_15483 "Acetylcholine synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15503 "Release of docked serotonin loaded synaptic vesicle, Homo sapiens" xref: Reactome:REACT_15517 "Dopamine synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15533 "Release of docked dopamine loaded synaptic vesicle, Homo sapiens" xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_23813 "Release of GABA at the synapse, Homo sapiens" xref: Reactome:REACT_23973 "GABA loaded synaptic vesicle Docking and Priming, Homo sapiens" xref: Reactome:REACT_29535 "Acetylcholine synaptic vesicle docking and priming, Danio rerio" xref: Reactome:REACT_31215 "Exocytosis of Insulin, Rattus norvegicus" xref: Reactome:REACT_31588 "Vamp2 associated secretory vesicle to plasma membrane transport, Danio rerio" xref: Reactome:REACT_34035 "Vamp2 associated secretory vesicle to plasma membrane transport, Mus musculus" xref: Reactome:REACT_77361 "Vamp2 associated secretory vesicle to plasma membrane transport, Sus scrofa" xref: Reactome:REACT_77506 "Glutamate synaptic vesicle docking and priming, Danio rerio" xref: Reactome:REACT_77785 "Vamp7 associated Lysosome to Plasma membrane transport, Danio rerio" xref: Reactome:REACT_77831 "release of L-Glutamate at the synapse, Mus musculus" xref: Reactome:REACT_79299 "Glutamate synaptic vesicle docking and priming, Mus musculus" xref: Reactome:REACT_80371 "Vamp2 associated secretory vesicle to plasma membrane transport, Bos taurus" xref: Reactome:REACT_82023 "Acetylcholine synaptic vesicle docking and priming, Mus musculus" xref: Reactome:REACT_82703 "Vamp7 associated Lysosome to Plasma membrane transport, Canis familiaris" xref: Reactome:REACT_83226 "Glutamate synaptic vesicle docking and priming, Rattus norvegicus" xref: Reactome:REACT_84308 "Release of noradrenaline at the synapse, Canis familiaris" xref: Reactome:REACT_84628 "Exocytosis of Insulin, Xenopus tropicalis" xref: Reactome:REACT_87193 "Glutamate synaptic vesicle docking and priming, Canis familiaris" xref: Reactome:REACT_87411 "Vamp8 associated secretory vesicle to plasma membrane transport, Canis familiaris" xref: Reactome:REACT_87768 "Vamp2 associated secretory vesicle to plasma membrane transport, Xenopus tropicalis" xref: Reactome:REACT_90536 "Vamp7 associated Lysosome to Plasma membrane transport, Arabidopsis thaliana" xref: Reactome:REACT_92466 "Vamp8 associated secretory vesicle to plasma membrane transport, Bos taurus" xref: Reactome:REACT_93575 "Release of acetylcholine at the synapse, Rattus norvegicus" xref: Reactome:REACT_93655 "Release of acetylcholine at the synapse, Canis familiaris" xref: Reactome:REACT_93705 "Noradrenalin synaptic vesicle docking and priming, Rattus norvegicus" xref: Reactome:REACT_94126 "Vamp8 associated secretory vesicle to plasma membrane transport, Danio rerio" xref: Reactome:REACT_94434 "Exocytosis of Insulin, Bos taurus" xref: Reactome:REACT_95323 "Vamp7 associated Lysosome to Plasma membrane transport, Oryza sativa" xref: Reactome:REACT_96543 "Glutamate synaptic vesicle docking and priming, Xenopus tropicalis" xref: Reactome:REACT_96609 "release of L-Glutamate at the synapse, Rattus norvegicus" xref: Reactome:REACT_96753 "Acetylcholine synaptic vesicle docking and priming, Xenopus tropicalis" xref: Reactome:REACT_96842 "Vamp8 associated secretory vesicle to plasma membrane transport, Mus musculus" xref: Reactome:REACT_97101 "Exocytosis of Insulin, Canis familiaris" xref: Reactome:REACT_98480 "Noradrenalin synaptic vesicle docking and priming, Xenopus tropicalis" xref: Reactome:REACT_98819 "Noradrenalin synaptic vesicle docking and priming, Danio rerio" xref: Reactome:REACT_99501 "Release of noradrenaline at the synapse, Mus musculus" is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: gosubset_prok synonym: "strand transferase" NARROW [] xref: Reactome:REACT_27300 "Formation of Meiotic Heteroduplex, Homo sapiens" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000154 name: rRNA modification namespace: biological_process alt_id: GO:0016548 def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "rRNA editing" NARROW [GOC:hjd] is_a: GO:0006364 ! rRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0000155 name: phosphorelay sensor kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] subset: gosubset_prok synonym: "two-component sensor activity" NARROW [] synonym: "two-component sensor molecule" NARROW [] synonym: "two-component system sensor activity " NARROW [] xref: EC:2.7.3.- is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0000156 name: phosphorelay response regulator activity namespace: molecular_function def: "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] subset: goslim_metagenomics subset: gosubset_prok synonym: "two-component response regulator activity" NARROW [] is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000160 name: phosphorelay signal transduction system namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: goslim_metagenomics subset: gosubset_prok synonym: "histidyl-aspartyl phosphorelay" EXACT [] synonym: "phosphorelay signal transduction system" NARROW [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0000161 name: MAPK cascade involved in osmosensory signaling pathway namespace: biological_process def: "A MAPK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267] synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736] synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736] synonym: "MAPKKK cascade during osmolarity sensing" EXACT [] synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling] synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] is_a: GO:0000165 ! MAPK cascade relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000162 name: tryptophan biosynthetic process namespace: biological_process alt_id: GO:0009096 def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY] subset: gosubset_prok synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] synonym: "tryptophan anabolism" EXACT [] synonym: "tryptophan biosynthesis" EXACT [] synonym: "tryptophan formation" EXACT [] synonym: "tryptophan synthesis" EXACT [] xref: MetaCyc:TRPSYN-PWY is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046219 ! indolalkylamine biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000165 name: MAPK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. synonym: "ERK/MAPK cascade" NARROW [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade" EXACT [GOC:curators] synonym: "MAPKKK cascade during sporulation" NARROW [] synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] xref: Reactome:REACT_101634 "RAF/MAP kinase cascade, Bos taurus" xref: Reactome:REACT_107261 "RAF/MAP kinase cascade, Saccharomyces cerevisiae" xref: Reactome:REACT_107863 "RAF/MAP kinase cascade, Canis familiaris" xref: Reactome:REACT_108330 "RAF/MAP kinase cascade, Xenopus tropicalis" xref: Reactome:REACT_112235 "RAF/MAP kinase cascade, Dictyostelium discoideum" xref: Reactome:REACT_112942 "RAF/MAP kinase cascade, Arabidopsis thaliana" xref: Reactome:REACT_113285 "RAF/MAP kinase cascade, Oryza sativa" xref: Reactome:REACT_634 "RAF/MAP kinase cascade, Homo sapiens" xref: Reactome:REACT_79658 "RAF/MAP kinase cascade, Schizosaccharomyces pombe" xref: Reactome:REACT_85806 "RAF/MAP kinase cascade, Drosophila melanogaster" xref: Reactome:REACT_87028 "RAF/MAP kinase cascade, Danio rerio" xref: Reactome:REACT_87232 "RAF/MAP kinase cascade, Mus musculus" xref: Reactome:REACT_87855 "RAF/MAP kinase cascade, Rattus norvegicus" xref: Reactome:REACT_92078 "RAF/MAP kinase cascade, Sus scrofa" xref: Reactome:REACT_92987 "RAF/MAP kinase cascade, Caenorhabditis elegans" xref: Reactome:REACT_94585 "RAF/MAP kinase cascade, Taeniopygia guttata" xref: Reactome:REACT_94805 "RAF/MAP kinase cascade, Gallus gallus" xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0036094 ! small molecule binding is_a: GO:1901265 ! nucleoside phosphate binding [Term] id: GO:0000167 name: activation of MAPKKK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity is_a: GO:0047484 ! regulation of response to osmotic stress is_a: GO:0080135 ! regulation of cellular response to stress [Term] id: GO:0000168 name: activation of MAPKK activity involved in osmosensory signaling pathway namespace: biological_process alt_id: GO:0007233 def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "activation of Pbs2 kinase" NARROW [] synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0047484 ! regulation of response to osmotic stress is_a: GO:0080135 ! regulation of cellular response to stress [Term] id: GO:0000169 name: activation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] synonym: "activation of MAPK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0047484 ! regulation of response to osmotic stress is_a: GO:0080135 ! regulation of cellular response to stress [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] xref: Reactome:REACT_100351 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Danio rerio" xref: Reactome:REACT_103503 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Gallus gallus" xref: Reactome:REACT_104963 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Canis familiaris" xref: Reactome:REACT_115687 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Gallus gallus" xref: Reactome:REACT_19258 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Homo sapiens" xref: Reactome:REACT_29940 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Oryza sativa" xref: Reactome:REACT_31871 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Drosophila melanogaster" xref: Reactome:REACT_80095 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Bos taurus" xref: Reactome:REACT_82371 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Xenopus tropicalis" xref: Reactome:REACT_85471 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Dictyostelium discoideum" xref: Reactome:REACT_85651 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Sus scrofa" xref: Reactome:REACT_86222 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Arabidopsis thaliana" xref: Reactome:REACT_91283 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Schizosaccharomyces pombe" xref: Reactome:REACT_92284 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Rattus norvegicus" xref: Reactome:REACT_96037 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Taeniopygia guttata" xref: Reactome:REACT_97092 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Caenorhabditis elegans" xref: Reactome:REACT_99475 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Mus musculus" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] synonym: "RNase MRP" EXACT [] xref: Wikipedia:RNase_MRP is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] synonym: "RNase MRP complex" EXACT [] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex [Term] id: GO:0000173 name: inactivation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT [] synonym: "inactivation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, inactivation of MAPK" EXACT [] synonym: "osmolarity sensing, termination of MAPK activity" EXACT [] synonym: "termination of MAPK activity during osmolarity sensing" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0047484 ! regulation of response to osmotic stress is_a: GO:0080135 ! regulation of cellular response to stress [Term] id: GO:0000174 name: inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13.- xref: Reactome:REACT_102966 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_108214 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Sus scrofa" xref: Reactome:REACT_20588 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Homo sapiens" xref: Reactome:REACT_33991 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Dictyostelium discoideum" xref: Reactome:REACT_34078 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Danio rerio" xref: Reactome:REACT_78363 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Bos taurus" xref: Reactome:REACT_82118 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Rattus norvegicus" xref: Reactome:REACT_88115 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Arabidopsis thaliana" xref: Reactome:REACT_89880 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Oryza sativa" xref: Reactome:REACT_92153 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Caenorhabditis elegans" xref: Reactome:REACT_93499 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Drosophila melanogaster" xref: Reactome:REACT_95913 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Canis familiaris" xref: Reactome:REACT_95921 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Mus musculus" xref: Reactome:REACT_96267 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Taeniopygia guttata" xref: Reactome:REACT_99422 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Xenopus tropicalis" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] synonym: "nuclear exosome (ribonuclease complex)" EXACT [] synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. subset: goslim_pir synonym: "exosome (ribonucleasease complex)" EXACT [] synonym: "exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function alt_id: GO:0043790 def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] subset: gosubset_prok synonym: "18S rRNA dimethylase activity" EXACT [] synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532] synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532] xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0022625 [Term] id: GO:0000181 name: cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0022627 [Term] id: GO:0000182 name: rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah] synonym: "ribosomal DNA binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] synonym: "chromatin silencing at ribosomal DNA" EXACT [] synonym: "heterochromatic silencing at rDNA" EXACT [] synonym: "rDNA chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] synonym: "mRNA catabolism, nonsense-mediated" EXACT [] synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] synonym: "nonsense-mediated mRNA decay" EXACT [] synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] xref: Reactome:REACT_75886 "Nonsense-Mediated Decay, Homo sapiens" xref: Wikipedia:Nonsense-mediated_decay xref: Wikipedia:Nonsense-mediated_mRNA_decay is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000185 name: activation of MAPKKK activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase" EXACT [] synonym: "activation of MAP3K activity" EXACT [GOC:bf] synonym: "activation of MAPKKK activity during sporulation" NARROW [] synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] synonym: "positive regulation of MAPKKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity [Term] id: GO:0000186 name: activation of MAPKK activity namespace: biological_process alt_id: GO:0007255 def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267] synonym: "activation of MAP kinase kinase activity" EXACT [] synonym: "activation of MAP/ERK kinase kinase" EXACT [] synonym: "activation of MAP2K activity" EXACT [GOC:bf] synonym: "activation of MAPKK activity during sporulation" NARROW [] synonym: "positive regulation of MAPKK activity" BROAD [] xref: Reactome:REACT_101798 "Prolonged ERK activation events, Mus musculus" xref: Reactome:REACT_102728 "Prolonged ERK activation events, Schizosaccharomyces pombe" xref: Reactome:REACT_103900 "Prolonged ERK activation events, Gallus gallus" xref: Reactome:REACT_104177 "MEK activation, Danio rerio" xref: Reactome:REACT_104271 "Prolonged ERK activation events, Canis familiaris" xref: Reactome:REACT_110634 "MEK activation, Canis familiaris" xref: Reactome:REACT_113771 "Prolonged ERK activation events, Arabidopsis thaliana" xref: Reactome:REACT_114228 "Prolonged ERK activation events, Dictyostelium discoideum" xref: Reactome:REACT_114817 "Prolonged ERK activation events, Oryza sativa" xref: Reactome:REACT_12005 "Prolonged ERK activation events, Homo sapiens" xref: Reactome:REACT_33773 "Prolonged ERK activation events, Caenorhabditis elegans" xref: Reactome:REACT_81505 "MEK activation, Gallus gallus" xref: Reactome:REACT_81553 "Prolonged ERK activation events, Xenopus tropicalis" xref: Reactome:REACT_82861 "MEK activation, Xenopus tropicalis" xref: Reactome:REACT_86719 "Prolonged ERK activation events, Rattus norvegicus" xref: Reactome:REACT_86891 "Prolonged ERK activation events, Bos taurus" xref: Reactome:REACT_87045 "Prolonged ERK activation events, Taeniopygia guttata" xref: Reactome:REACT_89175 "Prolonged ERK activation events, Danio rerio" xref: Reactome:REACT_89555 "MEK activation, Bos taurus" xref: Reactome:REACT_91625 "Prolonged ERK activation events, Drosophila melanogaster" xref: Reactome:REACT_94138 "Prolonged ERK activation events, Sus scrofa" xref: Reactome:REACT_94626 "MEK activation, Mus musculus" xref: Reactome:REACT_95763 "MEK activation, Taeniopygia guttata" xref: Reactome:REACT_962 "MEK activation, Homo sapiens" xref: Reactome:REACT_97271 "Prolonged ERK activation events, Saccharomyces cerevisiae" xref: Reactome:REACT_98727 "MEK activation, Rattus norvegicus" is_a: GO:0006468 ! protein phosphorylation is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043408 ! regulation of MAPK cascade [Term] id: GO:0000187 name: activation of MAPK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267] synonym: "activation of MAP kinase" EXACT [] synonym: "activation of MAPK activity during sporulation" NARROW [] synonym: "MAPK activation" EXACT [] xref: Reactome:REACT_100881 "activated TAK1 mediates p38 MAPK activation, Canis familiaris" xref: Reactome:REACT_101870 "ERK activation, Caenorhabditis elegans" xref: Reactome:REACT_101978 "ERK activation, Drosophila melanogaster" xref: Reactome:REACT_102664 "activated TAK1 mediates p38 MAPK activation, Caenorhabditis elegans" xref: Reactome:REACT_102813 "activated TAK1 mediates p38 MAPK activation, Arabidopsis thaliana" xref: Reactome:REACT_103235 "ERK activation, Sus scrofa" xref: Reactome:REACT_103251 "activated TAK1 mediates p38 MAPK activation, Dictyostelium discoideum" xref: Reactome:REACT_106101 "ERK activation, Bos taurus" xref: Reactome:REACT_112664 "ERK activation, Oryza sativa" xref: Reactome:REACT_113767 "ERK activation, Dictyostelium discoideum" xref: Reactome:REACT_114778 "ERK activation, Arabidopsis thaliana" xref: Reactome:REACT_1482 "ERK activation, Homo sapiens" xref: Reactome:REACT_21399 "activated TAK1 mediates p38 MAPK activation, Homo sapiens" xref: Reactome:REACT_25355 "MAPK activation in TLR cascade, Gallus gallus" xref: Reactome:REACT_25370 "Activated TAK1 mediates p38 MAP kinase phosphorylation, Gallus gallus" xref: Reactome:REACT_28684 "ERK activation, Gallus gallus" xref: Reactome:REACT_29727 "activated TAK1 mediates p38 MAPK activation, Xenopus tropicalis" xref: Reactome:REACT_30502 "ERK activation, Saccharomyces cerevisiae" xref: Reactome:REACT_32301 "activated TAK1 mediates p38 MAPK activation, Rattus norvegicus" xref: Reactome:REACT_34590 "ERK activation, Rattus norvegicus" xref: Reactome:REACT_77440 "activated TAK1 mediates p38 MAPK activation, Mus musculus" xref: Reactome:REACT_77987 "ERK activation, Taeniopygia guttata" xref: Reactome:REACT_78017 "activated TAK1 mediates p38 MAPK activation, Bos taurus" xref: Reactome:REACT_83894 "activated TAK1 mediates p38 MAPK activation, Sus scrofa" xref: Reactome:REACT_84937 "ERK activation, Schizosaccharomyces pombe" xref: Reactome:REACT_86273 "activated TAK1 mediates p38 MAPK activation, Taeniopygia guttata" xref: Reactome:REACT_86655 "activated TAK1 mediates p38 MAPK activation, Danio rerio" xref: Reactome:REACT_87442 "activated TAK1 mediates p38 MAPK activation, Drosophila melanogaster" xref: Reactome:REACT_88492 "ERK activation, Canis familiaris" xref: Reactome:REACT_88606 "ERK activation, Mus musculus" xref: Reactome:REACT_91962 "activated TAK1 mediates p38 MAPK activation, Oryza sativa" xref: Reactome:REACT_93371 "activated TAK1 mediates p38 MAPK activation, Gallus gallus" xref: Reactome:REACT_98123 "ERK activation, Xenopus tropicalis" xref: Reactome:REACT_99633 "ERK activation, Danio rerio" is_a: GO:0006468 ! protein phosphorylation is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity [Term] id: GO:0000188 name: inactivation of MAPK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] synonym: "inactivation of MAPK during sporulation" NARROW [] synonym: "termination of MAPK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity [Term] id: GO:0000189 name: MAPK import into nucleus namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "nuclear translocation of MAPK" NARROW [GOC:mah] xref: Reactome:REACT_103042 "Nuclear translocation of phospho-ERK-1 dimer, Schizosaccharomyces pombe" xref: Reactome:REACT_105886 "Nuclear translocation of phospho-ERK-2 dimer, Gallus gallus" xref: Reactome:REACT_106064 "Nuclear translocation of phospho-ERK-2 dimer, Mus musculus" xref: Reactome:REACT_107045 "Nuclear translocation of phospho-ERK-1 dimer, Canis familiaris" xref: Reactome:REACT_110766 "Nuclear translocation of phospho-ERK-1 dimer, Danio rerio" xref: Reactome:REACT_113196 "Nuclear translocation of phospho-ERK-1 dimer, Oryza sativa" xref: Reactome:REACT_114932 "Nuclear translocation of phospho-ERK-1 dimer, Dictyostelium discoideum" xref: Reactome:REACT_115101 "Nuclear translocation of phospho-ERK-1 dimer, Arabidopsis thaliana" xref: Reactome:REACT_1866 "Nuclear translocation of phospho-ERK-1 dimer, Homo sapiens" xref: Reactome:REACT_29004 "Nuclear translocation of phospho-ERK-1 dimer, Caenorhabditis elegans" xref: Reactome:REACT_32259 "Nuclear translocation of phospho-ERK-1 dimer, Saccharomyces cerevisiae" xref: Reactome:REACT_33595 "Nuclear translocation of phospho-ERK-1 dimer, Mus musculus" xref: Reactome:REACT_487 "Nuclear translocation of phospho-ERK-2 dimer, Homo sapiens" xref: Reactome:REACT_510 "Nuclear translocation of phospho-ERK-2 dimer, Rattus norvegicus" xref: Reactome:REACT_78269 "Nuclear translocation of phospho-ERK-2 dimer, Danio rerio" xref: Reactome:REACT_79422 "Nuclear translocation of phospho-ERK-2 dimer, Bos taurus" xref: Reactome:REACT_81446 "Nuclear translocation of phospho-ERK-2 dimer, Taeniopygia guttata" xref: Reactome:REACT_87335 "Nuclear translocation of phospho-ERK-2 dimer, Xenopus tropicalis" xref: Reactome:REACT_89933 "Nuclear translocation of phospho-ERK-1 dimer, Drosophila melanogaster" xref: Reactome:REACT_94910 "Nuclear translocation of phospho-ERK-1 dimer, Bos taurus" xref: Reactome:REACT_95119 "Nuclear translocation of phospho-ERK-2 dimer, Sus scrofa" xref: Reactome:REACT_97762 "Nuclear translocation of phospho-ERK-2 dimer, Canis familiaris" is_a: GO:0006606 ! protein import into nucleus relationship: part_of GO:0000165 ! MAPK cascade [Term] id: GO:0000190 name: MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000191 name: activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000192 name: activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000193 name: activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000194 name: inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000195 name: nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000196 name: MAPK cascade involved in cell wall biogenesis namespace: biological_process def: "A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling] synonym: "Mpk1 cascade" NARROW [PMID:10523653] synonym: "Slt2 cascade" NARROW [PMID:10523653] is_a: GO:0000165 ! MAPK cascade relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0000197 name: activation of MAPKKK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity is_a: GO:0044087 ! regulation of cellular component biogenesis [Term] id: GO:0000198 name: activation of MAPKK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0044087 ! regulation of cellular component biogenesis [Term] id: GO:0000199 name: activation of MAPK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0044087 ! regulation of cellular component biogenesis [Term] id: GO:0000200 name: inactivation of MAPK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity is_a: GO:0044087 ! regulation of cellular component biogenesis [Term] id: GO:0000201 name: MAPK import into nucleus involved in cell wall biogenesis namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah] synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah] synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah] is_a: GO:0000189 ! MAPK import into nucleus relationship: part_of GO:0000196 ! MAPK cascade involved in cell wall biogenesis [Term] id: GO:0000202 name: MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000203 name: activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000204 name: activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000205 name: activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000206 name: inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000207 name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000208 name: MAPK import into nucleus involved in osmosensory signaling pathway namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah] synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT [] synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah] synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah] synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah] is_a: GO:0000189 ! MAPK import into nucleus relationship: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194] synonym: "polyubiquitin" RELATED [] synonym: "protein polyubiquitinylation" EXACT [] synonym: "protein polyubiquitylation" EXACT [] xref: Reactome:REACT_75842 "Antigen processing: Ubiquitination & Proteasome degradation, Homo sapiens" is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] subset: gosubset_prok synonym: "NAD diphosphatase activity" EXACT [] synonym: "NAD pyrophosphatase activity" EXACT [] synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] xref: EC:3.6.1.22 xref: MetaCyc:NADPYROPHOSPHAT-RXN xref: RHEA:11803 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. is_obsolete: true consider: GO:0005515 consider: GO:0019941 consider: GO:0042787 [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] synonym: "meiotic spindle organisation" EXACT [GOC:curators] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA-intron endoribonuclease activity" EXACT [] synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] xref: EC:3.1.27.9 xref: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "SEN complex" EXACT [GOC:se, PMID:22391451] synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN is_a: GO:0008665 ! 2'-phosphotransferase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0000216 name: M/G1 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle] comment: This term was made obsolete because it does not refer to a real biological process. xref: Reactome:REACT_103126 "M/G1 Transition, Sus scrofa" xref: Reactome:REACT_103368 "M/G1 Transition, Taeniopygia guttata" xref: Reactome:REACT_105126 "M/G1 Transition, Caenorhabditis elegans" xref: Reactome:REACT_108209 "M/G1 Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_108301 "M/G1 Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_109437 "M/G1 Transition, Rattus norvegicus" xref: Reactome:REACT_110954 "M/G1 Transition, Dictyostelium discoideum" xref: Reactome:REACT_1725 "M/G1 Transition, Homo sapiens" xref: Reactome:REACT_32146 "M/G1 Transition, Arabidopsis thaliana" xref: Reactome:REACT_32196 "M/G1 Transition, Plasmodium falciparum" xref: Reactome:REACT_77227 "M/G1 Transition, Danio rerio" xref: Reactome:REACT_77394 "M/G1 Transition, Mus musculus" xref: Reactome:REACT_78459 "M/G1 Transition, Gallus gallus" xref: Reactome:REACT_79481 "M/G1 Transition, Drosophila melanogaster" xref: Reactome:REACT_83776 "M/G1 Transition, Oryza sativa" xref: Reactome:REACT_86397 "M/G1 Transition, Canis familiaris" xref: Reactome:REACT_89032 "M/G1 Transition, Xenopus tropicalis" xref: Reactome:REACT_94915 "M/G1 Transition, Bos taurus" is_obsolete: true [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0000219 name: vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" EXACT [] is_obsolete: true consider: GO:0016469 [Term] id: GO:0000220 name: vacuolar proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000221 name: vacuolar proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain generally consists of eight subunits. synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000223 name: plasma membrane proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: MetaCyc:3.5.1.52-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] xref: EC:3.5.1.89 xref: MetaCyc:3.1.1.69-RXN xref: Reactome:REACT_100003 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Gallus gallus" xref: Reactome:REACT_103061 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Taeniopygia guttata" xref: Reactome:REACT_107021 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Caenorhabditis elegans" xref: Reactome:REACT_111009 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Dictyostelium discoideum" xref: Reactome:REACT_114989 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Arabidopsis thaliana" xref: Reactome:REACT_29732 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Schizosaccharomyces pombe" xref: Reactome:REACT_32276 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Saccharomyces cerevisiae" xref: Reactome:REACT_33502 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Bos taurus" xref: Reactome:REACT_33809 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Drosophila melanogaster" xref: Reactome:REACT_77843 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Danio rerio" xref: Reactome:REACT_779 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Homo sapiens" xref: Reactome:REACT_82306 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Oryza sativa" xref: Reactome:REACT_82765 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Mus musculus" xref: Reactome:REACT_88022 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Plasmodium falciparum" xref: Reactome:REACT_88604 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Canis familiaris" xref: Reactome:REACT_91074 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Rattus norvegicus" xref: Reactome:REACT_98776 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Sus scrofa" xref: RHEA:11663 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "oxaloacetate carrier activity" RELATED [] is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000230 name: nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000794 [Term] id: GO:0000231 name: cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000793 [Term] id: GO:0000232 name: nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000228 [Term] id: GO:0000233 name: cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000229 [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] xref: EC:2.1.1.103 xref: KEGG:R02037 xref: MetaCyc:2.1.1.103-RXN xref: RHEA:20366 xref: RHEA:20368 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:dph, GOC:mah, ISBN:0198547684] subset: gocheck_do_not_annotate xref: Reactome:REACT_102823 "Mitotic Prometaphase, Mus musculus" xref: Reactome:REACT_104270 "Mitotic Prometaphase, Bos taurus" xref: Reactome:REACT_105082 "Mitotic Prometaphase, Dictyostelium discoideum" xref: Reactome:REACT_114704 "Mitotic Prometaphase, Schizosaccharomyces pombe" xref: Reactome:REACT_118069 "Mitotic Prometaphase, Gallus gallus" xref: Reactome:REACT_118526 "Mitotic Prometaphase, Saccharomyces cerevisiae" xref: Reactome:REACT_118539 "Mitotic Prometaphase, Taeniopygia guttata" xref: Reactome:REACT_31336 "Mitotic Prometaphase, Danio rerio" xref: Reactome:REACT_31385 "Mitotic Prometaphase, Caenorhabditis elegans" xref: Reactome:REACT_682 "Mitotic Prometaphase, Homo sapiens" xref: Reactome:REACT_79351 "Mitotic Prometaphase, Rattus norvegicus" xref: Reactome:REACT_83126 "Mitotic Prometaphase, Drosophila melanogaster" xref: Reactome:REACT_98905 "Mitotic Prometaphase, Xenopus tropicalis" xref: Reactome:REACT_99376 "Mitotic Prometaphase, Canis familiaris" is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the first stage of prophase I in meiosis, in which chromosomes first become visible." [GOC:dph, GOC:mah, ISBN:0198547684] subset: gocheck_do_not_annotate xref: Wikipedia:Leptotene xref: Wikipedia:Meiosis#Leptotene is_a: GO:0022403 ! cell cycle phase is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:dph, GOC:mah, ISBN:0198547684] subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Zygotene xref: Wikipedia:Zygotene is_a: GO:0022403 ! cell cycle phase is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:dph, GOC:mah, ISBN:0198547684] subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Pachytene xref: Wikipedia:Pachytene is_a: GO:0022403 ! cell cycle phase is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:dph, GOC:mah, ISBN:0198547684] subset: gocheck_do_not_annotate xref: Wikipedia:Diplotene xref: Wikipedia:Meiosis#Diplotene is_a: GO:0022403 ! cell cycle phase is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GOC:dph, GOC:mah, ISBN:0198547684] subset: gocheck_do_not_annotate xref: Wikipedia:Diakinesis xref: Wikipedia:Meiosis#Diakinesis is_a: GO:0022403 ! cell cycle phase is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140] synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah] synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex [Term] id: GO:0000244 name: assembly of spliceosomal tri-snRNP namespace: biological_process alt_id: GO:0000351 alt_id: GO:0000355 def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] synonym: "snRNP recycling" BROAD [] synonym: "spliceosomal tri-snRNP assembly" EXACT [] synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000387 ! spliceosomal snRNP assembly [Term] id: GO:0000245 name: spliceosomal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] synonym: "spliceosome assembly" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18504] subset: gosubset_prok synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "D24(24-1)-sterol reductase activity" EXACT [] synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] synonym: "sterol delta-24(28) reductase activity" EXACT [] synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] xref: EC:1.3.1.71 xref: KEGG:R05641 xref: MetaCyc:1.3.1.71-RXN xref: RHEA:18504 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026] synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] xref: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] synonym: "sterol-C5-desaturase activity" EXACT [] xref: Reactome:REACT_10092 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Homo sapiens" xref: Reactome:REACT_106801 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Taeniopygia guttata" xref: Reactome:REACT_108498 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Rattus norvegicus" xref: Reactome:REACT_110659 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Bos taurus" xref: Reactome:REACT_34122 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Danio rerio" xref: Reactome:REACT_34697 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Saccharomyces cerevisiae" xref: Reactome:REACT_79598 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Mus musculus" xref: Reactome:REACT_84206 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Oryza sativa" xref: Reactome:REACT_85577 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Sus scrofa" xref: Reactome:REACT_86700 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Canis familiaris" xref: Reactome:REACT_98513 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Schizosaccharomyces pombe" is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14624] subset: gosubset_prok synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7] synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "OSC" EXACT [] synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7] synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] xref: EC:5.4.99.7 xref: KEGG:R03199 xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref: Reactome:REACT_106250 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Danio rerio" xref: Reactome:REACT_112890 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Oryza sativa" xref: Reactome:REACT_114747 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Arabidopsis thaliana" xref: Reactome:REACT_29522 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Schizosaccharomyces pombe" xref: Reactome:REACT_33379 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Xenopus tropicalis" xref: Reactome:REACT_78122 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Taeniopygia guttata" xref: Reactome:REACT_84749 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Bos taurus" xref: Reactome:REACT_86645 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Saccharomyces cerevisiae" xref: Reactome:REACT_88346 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Rattus norvegicus" xref: Reactome:REACT_89548 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Gallus gallus" xref: Reactome:REACT_92166 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Dictyostelium discoideum" xref: Reactome:REACT_93681 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Canis familiaris" xref: Reactome:REACT_9391 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Homo sapiens" xref: Reactome:REACT_96289 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Mus musculus" xref: RHEA:14624 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] synonym: "C-3 sterol dehydrogenase activity" RELATED [] synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] xref: EC:1.1.1.- xref: Reactome:REACT_10053 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Homo sapiens" xref: Reactome:REACT_103278 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Sus scrofa" xref: Reactome:REACT_103729 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Bos taurus" xref: Reactome:REACT_105643 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Gallus gallus" xref: Reactome:REACT_106602 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Bos taurus" xref: Reactome:REACT_107465 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Canis familiaris" xref: Reactome:REACT_108692 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Mus musculus" xref: Reactome:REACT_108789 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Rattus norvegicus" xref: Reactome:REACT_109155 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Danio rerio" xref: Reactome:REACT_112688 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Mycobacterium tuberculosis" xref: Reactome:REACT_112771 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Escherichia coli" xref: Reactome:REACT_112854 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Schizosaccharomyces pombe" xref: Reactome:REACT_112960 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Saccharomyces cerevisiae" xref: Reactome:REACT_112995 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Schizosaccharomyces pombe" xref: Reactome:REACT_113072 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Oryza sativa" xref: Reactome:REACT_113373 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Dictyostelium discoideum" xref: Reactome:REACT_113553 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_114106 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Oryza sativa" xref: Reactome:REACT_114356 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Dictyostelium discoideum" xref: Reactome:REACT_115015 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Arabidopsis thaliana" xref: Reactome:REACT_115441 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Arabidopsis thaliana" xref: Reactome:REACT_30127 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Rattus norvegicus" xref: Reactome:REACT_31080 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Taeniopygia guttata" xref: Reactome:REACT_32363 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Sus scrofa" xref: Reactome:REACT_33091 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Canis familiaris" xref: Reactome:REACT_77107 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Gallus gallus" xref: Reactome:REACT_82876 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Xenopus tropicalis" xref: Reactome:REACT_85383 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Mus musculus" xref: Reactome:REACT_89091 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Xenopus tropicalis" xref: Reactome:REACT_91545 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Danio rerio" xref: Reactome:REACT_91980 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Taeniopygia guttata" xref: Reactome:REACT_9949 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Homo sapiens" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function alt_id: GO:0050576 def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3-keto-steroid reductase activity" EXACT [] synonym: "3-KSR activity" EXACT [EC:1.1.1.270] synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.270 xref: MetaCyc:1.1.1.270-RXN xref: MetaCyc:RXN3O-4110 xref: MetaCyc:RXN66-19 xref: MetaCyc:RXN66-24 xref: MetaCyc:RXN66-314 xref: MetaCyc:RXN66-319 xref: Reactome:REACT_10036 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Homo sapiens" xref: Reactome:REACT_10079 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Homo sapiens" xref: Reactome:REACT_101014 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Schizosaccharomyces pombe" xref: Reactome:REACT_102533 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis" xref: Reactome:REACT_103243 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Canis familiaris" xref: Reactome:REACT_103645 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Gallus gallus" xref: Reactome:REACT_106908 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Saccharomyces cerevisiae" xref: Reactome:REACT_107179 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata" xref: Reactome:REACT_108259 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Canis familiaris" xref: Reactome:REACT_31386 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Danio rerio" xref: Reactome:REACT_69122 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Sus scrofa" xref: Reactome:REACT_78849 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Mus musculus" xref: Reactome:REACT_79755 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Rattus norvegicus" xref: Reactome:REACT_82599 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe" xref: Reactome:REACT_82943 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Sus scrofa" xref: Reactome:REACT_84146 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Gallus gallus" xref: Reactome:REACT_88684 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Bos taurus" xref: Reactome:REACT_91551 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Mus musculus" xref: Reactome:REACT_92714 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Rattus norvegicus" xref: Reactome:REACT_95205 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Taeniopygia guttata" xref: Reactome:REACT_96469 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Bos taurus" xref: Reactome:REACT_96959 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Danio rerio" xref: Reactome:REACT_96973 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Xenopus tropicalis" xref: Reactome:REACT_97126 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae" xref: RHEA:18412 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4-methylsterol oxidase activity" EXACT [] synonym: "methylsterol hydroxylase activity" RELATED [] synonym: "methylsterol monooxygenase activity" RELATED [] xref: EC:1.14.13.72 xref: MetaCyc:1.14.13.72-RXN xref: Reactome:REACT_10059 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Homo sapiens" xref: Reactome:REACT_10070 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Homo sapiens" xref: Reactome:REACT_104089 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Danio rerio" xref: Reactome:REACT_104631 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Oryza sativa" xref: Reactome:REACT_105610 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata" xref: Reactome:REACT_105653 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Bos taurus" xref: Reactome:REACT_107576 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Dictyostelium discoideum" xref: Reactome:REACT_112865 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis" xref: Reactome:REACT_115505 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis" xref: Reactome:REACT_28712 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Mus musculus" xref: Reactome:REACT_29355 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Sus scrofa" xref: Reactome:REACT_31445 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Mus musculus" xref: Reactome:REACT_32207 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Sus scrofa" xref: Reactome:REACT_32840 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae" xref: Reactome:REACT_76969 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Oryza sativa" xref: Reactome:REACT_79112 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe" xref: Reactome:REACT_83222 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Gallus gallus" xref: Reactome:REACT_84661 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe" xref: Reactome:REACT_84707 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Arabidopsis thaliana" xref: Reactome:REACT_85609 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata" xref: Reactome:REACT_86519 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Canis familiaris" xref: Reactome:REACT_88988 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Canis familiaris" xref: Reactome:REACT_89551 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae" xref: Reactome:REACT_94158 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Gallus gallus" xref: Reactome:REACT_95387 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Danio rerio" xref: Reactome:REACT_95721 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Dictyostelium discoideum" xref: Reactome:REACT_96643 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Rattus norvegicus" xref: Reactome:REACT_97328 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Bos taurus" xref: Reactome:REACT_99679 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Rattus norvegicus" xref: Reactome:REACT_99766 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Arabidopsis thaliana" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "allantoin metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0000256 name: allantoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "allantoin breakdown" EXACT [] synonym: "allantoin catabolism" EXACT [] synonym: "allantoin degradation" EXACT [] is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] subset: gosubset_prok synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] xref: EC:3.5.5.1 xref: MetaCyc:3.5.5.1-RXN xref: RHEA:21727 xref: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005283 consider: GO:0005304 consider: GO:0015188 [Term] id: GO:0000259 name: intracellular nucleoside transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] comment: This term was made obsolete because it contains component and function information. is_obsolete: true replaced_by: GO:0005337 replaced_by: GO:0005622 [Term] id: GO:0000260 name: hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0000261 name: sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0046962 [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000264 name: heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000265 name: heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission [Term] id: GO:0000267 name: cell fraction namespace: cellular_component def: "OBSOLETE: A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. subset: goslim_pir subset: gosubset_prok is_obsolete: true consider: GO:0005575 [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function alt_id: GO:0005051 def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonym: "peroxisome targeting signal receptor" NARROW [] synonym: "PTS binding" EXACT [] synonym: "PTS receptor" NARROW [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolic process namespace: biological_process alt_id: GO:0009284 def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] subset: gosubset_prok synonym: "murein metabolic process" EXACT [] synonym: "murein metabolism" EXACT [] synonym: "peptidoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0000274 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0000275 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000276 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] subset: goslim_yeast xref: Reactome:REACT_100451 "Cell Cycle, Mitotic, Taeniopygia guttata" xref: Reactome:REACT_104035 "Cell Cycle, Mitotic, Sus scrofa" xref: Reactome:REACT_104195 "Cell Cycle, Mitotic, Canis familiaris" xref: Reactome:REACT_105856 "Cell Cycle, Mitotic, Danio rerio" xref: Reactome:REACT_108233 "Cell Cycle, Mitotic, Saccharomyces cerevisiae" xref: Reactome:REACT_152 "Cell Cycle, Mitotic, Homo sapiens" xref: Reactome:REACT_28464 "Cell Cycle, Mitotic, Xenopus tropicalis" xref: Reactome:REACT_28953 "Cell Cycle, Mitotic, Bos taurus" xref: Reactome:REACT_33388 "Cell Cycle, Mitotic, Rattus norvegicus" xref: Reactome:REACT_53493 "Cell Cycle, Mitotic, Plasmodium falciparum" xref: Reactome:REACT_79085 "Cell Cycle, Mitotic, Schizosaccharomyces pombe" xref: Reactome:REACT_84794 "Cell Cycle, Mitotic, Caenorhabditis elegans" xref: Reactome:REACT_85137 "Cell Cycle, Mitotic, Gallus gallus" xref: Reactome:REACT_85950 "Cell Cycle, Mitotic, Arabidopsis thaliana" xref: Reactome:REACT_90332 "Cell Cycle, Mitotic, Mus musculus" xref: Reactome:REACT_90846 "Cell Cycle, Mitotic, Oryza sativa" xref: Reactome:REACT_96281 "Cell Cycle, Mitotic, Drosophila melanogaster" xref: Reactome:REACT_97744 "Cell Cycle, Mitotic, Dictyostelium discoideum" xref: Reactome:REACT_98208 "Cell Cycle, Mitotic, Mycobacterium tuberculosis" is_a: GO:0007049 ! cell cycle [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division." [GOC:dph, GOC:mah, ISBN:0815316194] subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission [Term] id: GO:0000281 name: cytokinesis after mitosis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000282 name: cellular bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). synonym: "bud site selection/establishment of cell polarity" BROAD [] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0022402 ! cell cycle process is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000284 name: shmoo orientation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. is_obsolete: true replaced_by: GO:0000753 [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] xref: EC:2.7.1.150 xref: KEGG:R05802 xref: MetaCyc:2.7.1.150-RXN xref: RHEA:13612 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+)." [EC:1.4.1.1] subset: gosubset_prok synonym: "AlaDH" RELATED [EC:1.4.1.1] synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] xref: EC:1.4.1.1 xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN xref: RHEA:18408 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] subset: gosubset_prok synonym: "magnesium binding" EXACT [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] synonym: "deadenylation-dependent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] xref: Reactome:REACT_102357 "Deadenylation-dependent mRNA decay, Xenopus tropicalis" xref: Reactome:REACT_103296 "Deadenylation-dependent mRNA decay, Gallus gallus" xref: Reactome:REACT_105200 "Deadenylation-dependent mRNA decay, Plasmodium falciparum" xref: Reactome:REACT_110041 "Deadenylation-dependent mRNA decay, Caenorhabditis elegans" xref: Reactome:REACT_20639 "Deadenylation-dependent mRNA decay, Homo sapiens" xref: Reactome:REACT_49520 "Deadenylation-dependent mRNA decay, Rattus norvegicus" xref: Reactome:REACT_79530 "Deadenylation-dependent mRNA decay, Saccharomyces cerevisiae" xref: Reactome:REACT_82315 "Deadenylation-dependent mRNA decay, Sus scrofa" xref: Reactome:REACT_83961 "Deadenylation-dependent mRNA decay, Schizosaccharomyces pombe" xref: Reactome:REACT_89647 "Deadenylation-dependent mRNA decay, Drosophila melanogaster" xref: Reactome:REACT_90397 "Deadenylation-dependent mRNA decay, Mus musculus" xref: Reactome:REACT_93483 "Deadenylation-dependent mRNA decay, Taeniopygia guttata" xref: Reactome:REACT_95045 "Deadenylation-dependent mRNA decay, Oryza sativa" xref: Reactome:REACT_95337 "Deadenylation-dependent mRNA decay, Arabidopsis thaliana" xref: Reactome:REACT_96238 "Deadenylation-dependent mRNA decay, Dictyostelium discoideum" xref: Reactome:REACT_96993 "Deadenylation-dependent mRNA decay, Bos taurus" xref: Reactome:REACT_97186 "Deadenylation-dependent mRNA decay, Canis familiaris" xref: Reactome:REACT_99680 "Deadenylation-dependent mRNA decay, Danio rerio" is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000289 name: nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] synonym: "3' to 5' mRNA deadenylation" RELATED [] synonym: "mRNA deadenylation" RELATED [] synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] xref: Reactome:REACT_102415 "Deadenylation of mRNA, Rattus norvegicus" xref: Reactome:REACT_104397 "Deadenylation of mRNA, Danio rerio" xref: Reactome:REACT_109691 "Deadenylation of mRNA, Bos taurus" xref: Reactome:REACT_111968 "Deadenylation of mRNA, Drosophila melanogaster" xref: Reactome:REACT_20514 "Deadenylation of mRNA, Homo sapiens" xref: Reactome:REACT_30693 "Deadenylation of mRNA, Xenopus tropicalis" xref: Reactome:REACT_31579 "Deadenylation of mRNA, Canis familiaris" xref: Reactome:REACT_78492 "Deadenylation of mRNA, Mus musculus" xref: Reactome:REACT_83021 "Deadenylation of mRNA, Taeniopygia guttata" is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0031124 ! mRNA 3'-end processing relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000290 name: deadenylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] synonym: "deadenylylation-dependent decapping" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000291 name: nuclear-transcribed mRNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] synonym: "exonucleolytic degradation of mRNA" EXACT [] synonym: "mRNA breakdown, exonucleolytic" EXACT [] synonym: "mRNA degradation, exonucleolytic" EXACT [] synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000292 name: RNA fragment catabolic process namespace: biological_process alt_id: GO:0030452 def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] subset: gosubset_prok synonym: "group I intron catabolic process" NARROW [] synonym: "RNA fragment breakdown" EXACT [] synonym: "RNA fragment catabolism" EXACT [GOC:mah] synonym: "RNA fragment degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN xref: RHEA:15064 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0000294 name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay namespace: biological_process def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] synonym: "endonucleolytic mRNA decay" EXACT [] synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "mRNA catabolic process, endonucleolytic" EXACT [] synonym: "mRNA catabolism, endonucleolytic" EXACT [] synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000295 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870] xref: Reactome:REACT_101864 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Bos taurus" xref: Reactome:REACT_107442 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Rattus norvegicus" xref: Reactome:REACT_113419 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Oryza sativa" xref: Reactome:REACT_16948 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Homo sapiens" xref: Reactome:REACT_28950 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Mus musculus" xref: Reactome:REACT_30244 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Drosophila melanogaster" xref: Reactome:REACT_33254 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Dictyostelium discoideum" xref: Reactome:REACT_80715 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Taeniopygia guttata" xref: Reactome:REACT_83323 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Gallus gallus" xref: Reactome:REACT_85299 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Saccharomyces cerevisiae" xref: Reactome:REACT_86138 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Canis familiaris" xref: Reactome:REACT_86805 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Danio rerio" xref: Reactome:REACT_89005 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Sus scrofa" xref: Reactome:REACT_91614 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Xenopus tropicalis" is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0000296 name: spermine transport namespace: biological_process def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0006812 ! cation transport is_a: GO:0015846 ! polyamine transport [Term] id: GO:0000297 name: spermine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity [Term] id: GO:0000298 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000299 name: integral to membrane of membrane fraction namespace: cellular_component def: "OBSOLETE: Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. is_obsolete: true consider: GO:0016021 [Term] id: GO:0000300 name: peripheral to membrane of membrane fraction namespace: cellular_component def: "OBSOLETE: Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. is_obsolete: true consider: GO:0019898 [Term] id: GO:0000301 name: retrograde transport, vesicle recycling within Golgi namespace: biological_process def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] subset: gosubset_prok synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000304 name: response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000306 name: extrinsic to vacuolar membrane namespace: cellular_component def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0000307 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] subset: goslim_pir synonym: "CDK holoenzyme" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000308 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000309 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] subset: gosubset_prok synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMNAT activity" NARROW [EC:2.7.7.1] xref: EC:2.7.7.1 xref: MetaCyc:2.7.7.1-RXN xref: Reactome:REACT_101807 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Sus scrofa" xref: Reactome:REACT_102033 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Canis familiaris" xref: Reactome:REACT_103802 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Mus musculus" xref: Reactome:REACT_105839 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Xenopus tropicalis" xref: Reactome:REACT_107769 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Canis familiaris" xref: Reactome:REACT_107952 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Drosophila melanogaster" xref: Reactome:REACT_108630 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Sus scrofa" xref: Reactome:REACT_108997 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Sus scrofa" xref: Reactome:REACT_11116 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Homo sapiens" xref: Reactome:REACT_11196 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Homo sapiens" xref: Reactome:REACT_112138 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Arabidopsis thaliana" xref: Reactome:REACT_11237 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Homo sapiens" xref: Reactome:REACT_112385 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Oryza sativa" xref: Reactome:REACT_114383 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Dictyostelium discoideum" xref: Reactome:REACT_114560 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Schizosaccharomyces pombe" xref: Reactome:REACT_114828 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Saccharomyces cerevisiae" xref: Reactome:REACT_115028 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Dictyostelium discoideum" xref: Reactome:REACT_29972 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Caenorhabditis elegans" xref: Reactome:REACT_30979 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Oryza sativa" xref: Reactome:REACT_31171 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Arabidopsis thaliana" xref: Reactome:REACT_31453 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Taeniopygia guttata" xref: Reactome:REACT_70840 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Saccharomyces cerevisiae" xref: Reactome:REACT_77837 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Oryza sativa" xref: Reactome:REACT_78904 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Dictyostelium discoideum" xref: Reactome:REACT_79519 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Rattus norvegicus" xref: Reactome:REACT_79745 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Danio rerio" xref: Reactome:REACT_79909 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Canis familiaris" xref: Reactome:REACT_80724 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Schizosaccharomyces pombe" xref: Reactome:REACT_80917 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Danio rerio" xref: Reactome:REACT_81520 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Taeniopygia guttata" xref: Reactome:REACT_81532 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Bos taurus" xref: Reactome:REACT_83285 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Mus musculus" xref: Reactome:REACT_84119 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Mus musculus" xref: Reactome:REACT_86854 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Xenopus tropicalis" xref: Reactome:REACT_90006 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Saccharomyces cerevisiae" xref: Reactome:REACT_92077 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Gallus gallus" xref: Reactome:REACT_93517 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Drosophila melanogaster" xref: Reactome:REACT_95186 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Rattus norvegicus" xref: Reactome:REACT_96395 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Schizosaccharomyces pombe" xref: Reactome:REACT_96707 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Gallus gallus" xref: Reactome:REACT_97201 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Rattus norvegicus" xref: Reactome:REACT_97323 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Taeniopygia guttata" xref: Reactome:REACT_97434 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Arabidopsis thaliana" xref: Reactome:REACT_98853 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Bos taurus" xref: RHEA:21363 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0000310 name: xanthine phosphoribosyltransferase activity namespace: molecular_function alt_id: GO:0009043 def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt] subset: gosubset_prok synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] xref: EC:2.4.2.22 xref: MetaCyc:XANPRIBOSYLTRAN-RXN xref: RHEA:10803 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000311 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0044435 ! plastid part relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000312 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0044435 ! plastid part relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome is_a: GO:0044422 ! organelle part [Term] id: GO:0000314 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] is_a: GO:0015935 ! small ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000315 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0015934 ! large ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000316 name: sulfite transport namespace: biological_process def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sulphite transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000319 name: sulfite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] synonym: "sulphite transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000324 name: fungal-type vacuole namespace: cellular_component def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0000325 name: plant-type vacuole namespace: cellular_component def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208] synonym: "vacuole, cell cycle-independent morphology" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0000326 name: protein storage vacuole namespace: cellular_component def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409] is_a: GO:0000322 ! storage vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0000327 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] is_a: GO:0000323 ! lytic vacuole is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0000328 name: fungal-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000329 name: fungal-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "fungal-type vacuolar membrane" RELATED [] synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000330 name: plant-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0000331 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, PMID:10503189] xref: Wikipedia:Contractile_vacuole is_a: GO:0005773 ! vacuole is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] is_a: GO:0000497 ! base pairing with DNA relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0000333 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619] is_a: GO:0005697 ! telomerase holoenzyme complex [Term] id: GO:0000334 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17956] subset: gosubset_prok synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3HAO" RELATED [EC:1.13.11.6] xref: EC:1.13.11.6 xref: KEGG:R02665 xref: MetaCyc:1.13.11.6-RXN xref: Reactome:REACT_106067 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Danio rerio" xref: Reactome:REACT_107237 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Rattus norvegicus" xref: Reactome:REACT_108663 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Taeniopygia guttata" xref: Reactome:REACT_108942 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Canis familiaris" xref: Reactome:REACT_612 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Homo sapiens" xref: Reactome:REACT_78765 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Caenorhabditis elegans" xref: Reactome:REACT_81621 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Sus scrofa" xref: Reactome:REACT_83535 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Saccharomyces cerevisiae" xref: Reactome:REACT_83862 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Dictyostelium discoideum" xref: Reactome:REACT_84121 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Gallus gallus" xref: Reactome:REACT_86308 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Xenopus tropicalis" xref: Reactome:REACT_93632 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Bos taurus" xref: Reactome:REACT_94190 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Mus musculus" xref: RHEA:17956 xref: UM-BBD_reactionID:r1027 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0000335 name: negative regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] subset: gosubset_prok synonym: "down regulation of DNA transposition" EXACT [] synonym: "down-regulation of DNA transposition" EXACT [] synonym: "downregulation of DNA transposition" EXACT [] synonym: "inhibition of DNA transposition" NARROW [] synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0045910 ! negative regulation of DNA recombination relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000336 name: positive regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] subset: gosubset_prok synonym: "activation of DNA transposition" NARROW [] synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] synonym: "stimulation of DNA transposition" NARROW [] synonym: "up regulation of DNA transposition" EXACT [] synonym: "up-regulation of DNA transposition" EXACT [] synonym: "upregulation of DNA transposition" EXACT [] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0045911 ! positive regulation of DNA recombination relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000337 name: regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] subset: gosubset_prok synonym: "regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0010528 ! regulation of transposition relationship: regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000338 name: protein deneddylation namespace: biological_process def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0000339 name: RNA cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc] synonym: "binding to mRNA cap" NARROW [] synonym: "mRNA cap binding" NARROW [] synonym: "snRNA cap binding" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000340 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] synonym: "RNA m7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000341 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] synonym: "RNA m2,2,7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000342 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000343 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] synonym: "PEP-A" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000344 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] synonym: "PEP-B" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000345 name: cytosolic DNA-directed RNA polymerase complex namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] subset: gosubset_prok is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000346 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] subset: goslim_pir synonym: "TREX complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000347 name: THO complex namespace: cellular_component def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000348 name: mRNA branch site recognition namespace: biological_process alt_id: GO:0000370 alt_id: GO:0000371 def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). synonym: "nuclear mRNA branch site recognition" EXACT [GOC:vw] synonym: "spliceosomal A complex biosynthesis" NARROW [] synonym: "spliceosomal A complex formation" NARROW [] synonym: "spliceosomal B complex biosynthesis" NARROW [] synonym: "spliceosomal B complex formation" NARROW [] synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly [Term] id: GO:0000349 name: generation of catalytic spliceosome for first transesterification step namespace: biological_process alt_id: GO:0000356 alt_id: GO:0000357 def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-2 complex formation" NARROW [] synonym: "spliceosomal C1 complex biosynthesis" NARROW [] synonym: "spliceosomal C1 complex formation" NARROW [] synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000350 name: generation of catalytic spliceosome for second transesterification step namespace: biological_process alt_id: GO:0000358 alt_id: GO:0000359 def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] synonym: "formation of spliceosomal A2-2 complex" NARROW [] synonym: "formation of spliceosomal C1 complex" NARROW [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-3 complex formation" NARROW [] synonym: "spliceosomal C2 complex biosynthesis" NARROW [] synonym: "spliceosomal C2 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000352 name: trans assembly of SL-containing precatalytic spliceosome namespace: biological_process def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition [Term] id: GO:0000353 name: formation of quadruple SL/U4/U5/U6 snRNP namespace: biological_process def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] comment: Note that this step is analogous to 5' splice site selection in cis-splicing. is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition [Term] id: GO:0000354 name: cis assembly of pre-catalytic spliceosome namespace: biological_process alt_id: GO:0000360 alt_id: GO:0000361 def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] synonym: "formation of spliceosomal A2-1 complex" NARROW [] synonym: "formation of spliceosomal B1 complex" NARROW [] synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-1 complex formation" NARROW [] synonym: "spliceosomal B1 complex biosynthesis" NARROW [] synonym: "spliceosomal B1 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome [Term] id: GO:0000362 name: first U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000363 name: first U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000364 name: second U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000365 name: mRNA trans splicing, via spliceosome namespace: biological_process def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA trans splicing, via spliceosome" EXACT [GOC:vw] synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000366 name: intergenic mRNA trans splicing namespace: biological_process def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] synonym: "intergenic nuclear mRNA trans splicing" EXACT [GOC:vw] is_a: GO:0000365 ! mRNA trans splicing, via spliceosome is_a: GO:0000380 ! alternative mRNA splicing, via spliceosome [Term] id: GO:0000367 name: second U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000372 name: Group I intron splicing namespace: biological_process def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). subset: gosubset_prok synonym: "mRNA splicing" RELATED [] is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile [Term] id: GO:0000373 name: Group II intron splicing namespace: biological_process def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. subset: gosubset_prok synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000374 name: Group III intron splicing namespace: biological_process def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. subset: gosubset_prok synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000375 name: RNA splicing, via transesterification reactions namespace: biological_process alt_id: GO:0000385 alt_id: GO:0031202 def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] synonym: "spliceosomal catalysis" RELATED [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000376 name: RNA splicing, via transesterification reactions with guanosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] subset: gosubset_prok is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000377 name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] subset: gosubset_prok synonym: "lariat RNA biosynthesis" RELATED [] synonym: "lariat RNA formation" RELATED [] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000378 name: RNA exon ligation namespace: biological_process def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] comment: Note that this is not a part of spliceosomal RNA splicing. subset: gosubset_prok is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000379 name: tRNA-type intron splice site recognition and cleavage namespace: biological_process def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: gosubset_prok is_a: GO:0006396 ! RNA processing relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000380 name: alternative mRNA splicing, via spliceosome namespace: biological_process def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. synonym: "alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "splice site selection" BROAD [] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000381 name: regulation of alternative mRNA splicing, via spliceosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] synonym: "regulation of alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "splice site selection" BROAD [] is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome relationship: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome [Term] id: GO:0000384 name: first spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000386 name: second spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000387 name: spliceosomal snRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah] xref: Reactome:REACT_10002 "snRNA Cap hypermethylation, Homo sapiens" xref: Reactome:REACT_10041 "Loading and methylation of Sm proteins onto SMN Complexes, Homo sapiens" xref: Reactome:REACT_100869 "snRNP:Snurportin complex formation, Canis familiaris" xref: Reactome:REACT_100915 "snRNP:Snurportin complex formation, Rattus norvegicus" xref: Reactome:REACT_101141 "snRNP Assembly, Mus musculus" xref: Reactome:REACT_102135 "snRNA Cap hypermethylation, Danio rerio" xref: Reactome:REACT_102362 "snRNP complex assembly, Danio rerio" xref: Reactome:REACT_107811 "snRNP Assembly, Gallus gallus" xref: Reactome:REACT_108169 "snRNA Cap hypermethylation, Rattus norvegicus" xref: Reactome:REACT_108689 "snRNP Assembly, Rattus norvegicus" xref: Reactome:REACT_109502 "Loading and methylation of Sm proteins onto SMN Complexes, Danio rerio" xref: Reactome:REACT_11066 "snRNP Assembly, Homo sapiens" xref: Reactome:REACT_112455 "Loading and methylation of Sm proteins onto SMN Complexes, Xenopus tropicalis" xref: Reactome:REACT_29060 "snRNP:Snurportin complex formation, Drosophila melanogaster" xref: Reactome:REACT_29381 "snRNA Cap hypermethylation, Gallus gallus" xref: Reactome:REACT_29703 "snRNP Assembly, Taeniopygia guttata" xref: Reactome:REACT_29866 "snRNP:Snurportin complex formation, Mus musculus" xref: Reactome:REACT_30125 "snRNP complex assembly, Bos taurus" xref: Reactome:REACT_30397 "snRNP Assembly, Sus scrofa" xref: Reactome:REACT_30799 "snRNP:Snurportin complex formation, Danio rerio" xref: Reactome:REACT_30895 "snRNP complex assembly, Canis familiaris" xref: Reactome:REACT_31007 "snRNP complex assembly, Mus musculus" xref: Reactome:REACT_31363 "snRNP complex assembly, Gallus gallus" xref: Reactome:REACT_31615 "snRNP Assembly, Drosophila melanogaster" xref: Reactome:REACT_32359 "snRNP complex assembly, Rattus norvegicus" xref: Reactome:REACT_54083 "snRNA Cap hypermethylation, Bos taurus" xref: Reactome:REACT_77054 "snRNP Assembly, Canis familiaris" xref: Reactome:REACT_79845 "snRNA Cap hypermethylation, Xenopus tropicalis" xref: Reactome:REACT_81235 "Loading and methylation of Sm proteins onto SMN Complexes, Mus musculus" xref: Reactome:REACT_81911 "snRNP complex assembly, Xenopus tropicalis" xref: Reactome:REACT_82745 "snRNA Cap hypermethylation, Drosophila melanogaster" xref: Reactome:REACT_85882 "snRNP Assembly, Danio rerio" xref: Reactome:REACT_86133 "snRNP complex assembly, Drosophila melanogaster" xref: Reactome:REACT_88437 "snRNP Assembly, Xenopus tropicalis" xref: Reactome:REACT_88858 "snRNA Cap hypermethylation, Canis familiaris" xref: Reactome:REACT_93259 "snRNP:Snurportin complex formation, Xenopus tropicalis" xref: Reactome:REACT_93444 "snRNP Assembly, Bos taurus" xref: Reactome:REACT_93869 "snRNP:Snurportin complex formation, Gallus gallus" xref: Reactome:REACT_95210 "snRNA Cap hypermethylation, Mus musculus" xref: Reactome:REACT_99021 "snRNP:Snurportin complex formation, Bos taurus" xref: Reactome:REACT_9946 "snRNP:Snurportin complex formation, Homo sapiens" xref: Reactome:REACT_9957 "snRNP complex assembly, Homo sapiens" is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000388 name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) namespace: biological_process alt_id: GO:0000396 alt_id: GO:0000397 def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "spliceosomal A1 complex biosynthesis" NARROW [] synonym: "spliceosomal A1 complex formation" NARROW [] synonym: "spliceosomal B2 complex biosynthesis" NARROW [] synonym: "spliceosomal B2 complex formation" NARROW [] synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000389 name: mRNA 3'-splice site recognition namespace: biological_process alt_id: GO:0000382 alt_id: GO:0000383 def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA 3'-splice site recognition" EXACT [GOC:vw] synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection [Term] id: GO:0000390 name: spliceosomal complex disassembly namespace: biological_process alt_id: GO:0000391 alt_id: GO:0000392 def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "spliceosome complex disassembly" EXACT [] synonym: "spliceosome disassembly" BROAD [] synonym: "U12-type spliceosome disassembly" NARROW [] synonym: "U2-type spliceosome disassembly" NARROW [] is_a: GO:0032988 ! ribonucleoprotein complex disassembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000393 name: spliceosomal conformational changes to generate catalytic conformation namespace: biological_process def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000394 name: RNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "mRNA splicing" BROAD [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000395 name: mRNA 5'-splice site recognition namespace: biological_process alt_id: GO:0000368 alt_id: GO:0000369 def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). synonym: "nuclear mRNA 5' splice site recognition" EXACT [] synonym: "nuclear mRNA 5'-splice site recognition" EXACT [GOC:vw] synonym: "spliceosomal CC complex biosynthesis" NARROW [] synonym: "spliceosomal CC complex formation" NARROW [] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome [Term] id: GO:0000398 name: mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0006374 alt_id: GO:0006375 def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. synonym: "mRNA splicing" BROAD [] synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw] synonym: "pre-mRNA splicing" BROAD [] synonym: "splicing AT-AC intron" RELATED [] synonym: "splicing GT-AG intron" RELATED [] xref: Reactome:REACT_101135 "mRNA Splicing - Minor Pathway, Drosophila melanogaster" xref: Reactome:REACT_101749 "mRNA Splicing - Minor Pathway, Caenorhabditis elegans" xref: Reactome:REACT_106268 "mRNA Splicing - Major Pathway, Gallus gallus" xref: Reactome:REACT_107907 "mRNA Splicing - Minor Pathway, Schizosaccharomyces pombe" xref: Reactome:REACT_109091 "mRNA Splicing - Minor Pathway, Rattus norvegicus" xref: Reactome:REACT_112200 "mRNA Splicing - Major Pathway, Arabidopsis thaliana" xref: Reactome:REACT_114266 "mRNA Splicing - Major Pathway, Oryza sativa" xref: Reactome:REACT_114738 "mRNA Splicing - Major Pathway, Taeniopygia guttata" xref: Reactome:REACT_1753 "mRNA Splicing - Minor Pathway, Homo sapiens" xref: Reactome:REACT_30984 "mRNA Splicing - Minor Pathway, Plasmodium falciparum" xref: Reactome:REACT_32449 "mRNA Splicing - Minor Pathway, Canis familiaris" xref: Reactome:REACT_34020 "mRNA Splicing - Minor Pathway, Dictyostelium discoideum" xref: Reactome:REACT_467 "mRNA Splicing - Major Pathway, Homo sapiens" xref: Reactome:REACT_81417 "mRNA Splicing - Major Pathway, Canis familiaris" xref: Reactome:REACT_82149 "mRNA Splicing - Minor Pathway, Danio rerio" xref: Reactome:REACT_85452 "mRNA Splicing - Major Pathway, Bos taurus" xref: Reactome:REACT_86489 "mRNA Splicing - Minor Pathway, Mus musculus" xref: Reactome:REACT_88186 "mRNA Splicing - Minor Pathway, Oryza sativa" xref: Reactome:REACT_89168 "mRNA Splicing - Minor Pathway, Gallus gallus" xref: Reactome:REACT_90296 "mRNA Splicing - Major Pathway, Danio rerio" xref: Reactome:REACT_91088 "mRNA Splicing - Minor Pathway, Arabidopsis thaliana" xref: Reactome:REACT_91611 "mRNA Splicing - Major Pathway, Drosophila melanogaster" xref: Reactome:REACT_91773 "mRNA Splicing - Minor Pathway, Bos taurus" xref: Reactome:REACT_93740 "mRNA Splicing - Major Pathway, Caenorhabditis elegans" xref: Reactome:REACT_93843 "mRNA Splicing - Major Pathway, Rattus norvegicus" xref: Reactome:REACT_95764 "mRNA Splicing - Major Pathway, Mus musculus" xref: Reactome:REACT_99123 "mRNA Splicing - Major Pathway, Xenopus tropicalis" xref: Reactome:REACT_99763 "mRNA Splicing - Minor Pathway, Xenopus tropicalis" is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile is_a: GO:0006397 ! mRNA processing [Term] id: GO:0000399 name: cellular bud neck septin structure namespace: cellular_component def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] is_a: GO:0032155 ! cell division site part relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000400 name: four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "forked DNA binding" BROAD [] synonym: "Holliday junction binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000401 name: open form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "open form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000402 name: crossed form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "crossed form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000403 name: Y-form DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] synonym: "forked DNA binding" BROAD [] synonym: "splayed Y-form DNA binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000404 name: loop DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0000405 name: bubble DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, GOC:vw, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000406 name: double-strand/single-strand DNA junction binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000407 name: pre-autophagosomal structure namespace: cellular_component def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] synonym: "isolation membrane" RELATED [] synonym: "PAS" EXACT [] synonym: "perivacuolar space" NARROW [] synonym: "phagophore" RELATED [GOC:bf] synonym: "phagophore assembly site" RELATED [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000408 name: EKC/KEOPS complex namespace: cellular_component def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308] synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT [] synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000409 name: regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0000410 name: negative regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah] synonym: "down regulation of transcription by galactose" EXACT [] synonym: "down-regulation of transcription by galactose" EXACT [] synonym: "downregulation of transcription by galactose" EXACT [] synonym: "inhibition of transcription by galactose" NARROW [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000411 name: positive regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by galactose" NARROW [] synonym: "stimulation of transcription by galactose" NARROW [] synonym: "up regulation of transcription by galactose" EXACT [] synonym: "up-regulation of transcription by galactose" EXACT [] synonym: "upregulation of transcription by galactose" EXACT [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000412 name: histone peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] synonym: "histone proline isomerization" EXACT [] is_a: GO:0000413 ! protein peptidyl-prolyl isomerization is_a: GO:0016570 ! histone modification [Term] id: GO:0000413 name: protein peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] synonym: "protein proline isomerization" EXACT [] is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0000414 name: regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000415 name: negative regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "down regulation of histone H3-K36 methylation" EXACT [] synonym: "down-regulation of histone H3-K36 methylation" EXACT [] synonym: "downregulation of histone H3-K36 methylation" EXACT [] synonym: "inhibition of histone H3-K36 methylation" NARROW [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031061 ! negative regulation of histone methylation relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000416 name: positive regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "activation of histone H3-K36 methylation" NARROW [] synonym: "stimulation of histone H3-K36 methylation" NARROW [] synonym: "up regulation of histone H3-K36 methylation" EXACT [] synonym: "up-regulation of histone H3-K36 methylation" EXACT [] synonym: "upregulation of histone H3-K36 methylation" EXACT [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031062 ! positive regulation of histone methylation relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000417 name: HIR complex namespace: cellular_component def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105] is_a: GO:0043234 ! protein complex [Term] id: GO:0000418 name: DNA-directed RNA polymerase IV complex namespace: cellular_component alt_id: GO:0000420 def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459] synonym: "DNA-directed RNA polymerase IVa complex" EXACT [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000419 name: DNA-directed RNA polymerase V complex namespace: cellular_component alt_id: GO:0080137 def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459] synonym: "DNA-directed RNA polymerase IVb complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000421 name: autophagic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete] synonym: "autophagosome membrane" EXACT [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005776 ! autophagic vacuole [Term] id: GO:0000422 name: mitochondrion degradation namespace: biological_process def: "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [PMID:15798367] synonym: "mitophagy" EXACT [] xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy xref: Wikipedia:Mitophagy is_a: GO:0006914 ! autophagy [Term] id: GO:0000423 name: macromitophagy namespace: biological_process def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367] is_a: GO:0000422 ! mitochondrion degradation is_a: GO:0016236 ! macroautophagy [Term] id: GO:0000424 name: micromitophagy namespace: biological_process def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367] is_a: GO:0000422 ! mitochondrion degradation is_a: GO:0016237 ! microautophagy [Term] id: GO:0000425 name: macropexophagy namespace: biological_process def: "Degradation of a peroxisome by macropexophagy." [PMID:12914914, PMID:16973210] is_a: GO:0016236 ! macroautophagy is_a: GO:0030242 ! peroxisome degradation [Term] id: GO:0000426 name: micropexophagy namespace: biological_process def: "Degradation of a peroxisome by micropexophagy." [PMID:12914914, PMID:16973210] is_a: GO:0016237 ! microautophagy is_a: GO:0030242 ! peroxisome degradation [Term] id: GO:0000427 name: plastid-encoded plastid RNA polymerase complex namespace: cellular_component def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044435 ! plastid part [Term] id: GO:0000428 name: DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0000429 name: carbon catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0000430 name: regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0000431 name: regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000432 name: positive regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter is_a: GO:0046016 ! positive regulation of transcription by glucose [Term] id: GO:0000433 name: negative regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter is_a: GO:0045014 ! negative regulation of transcription by glucose [Term] id: GO:0000434 name: negative regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] is_a: GO:0000410 ! negative regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter [Term] id: GO:0000435 name: positive regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] is_a: GO:0000411 ! positive regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter [Term] id: GO:0000436 name: carbon catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000437 name: carbon catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc] synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000438 name: core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000439 ! core TFIIH complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0000443 ! SSL2-core TFIIH complex portion of holo TFIIH complex [Term] id: GO:0000439 name: core TFIIH complex namespace: cellular_component def: "The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex relationship: part_of GO:0000441 ! SSL2-core TFIIH complex [Term] id: GO:0000440 name: core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000439 ! core TFIIH complex relationship: part_of GO:0000442 ! SSL2-core TFIIH complex portion of NEF3 complex [Term] id: GO:0000441 name: SSL2-core TFIIH complex namespace: cellular_component def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] subset: goslim_pir is_a: GO:0043234 ! protein complex [Term] id: GO:0000442 name: SSL2-core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000441 ! SSL2-core TFIIH complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex [Term] id: GO:0000443 name: SSL2-core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000441 ! SSL2-core TFIIH complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0005675 ! holo TFIIH complex [Term] id: GO:0000444 name: MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] synonym: "Mis12 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000445 name: THO complex part of transcription export complex namespace: cellular_component def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] synonym: "THO complex part of TREX complex" EXACT [] is_a: GO:0000347 ! THO complex relationship: part_of GO:0000346 ! transcription export complex [Term] id: GO:0000446 name: nucleoplasmic THO complex namespace: cellular_component def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] is_a: GO:0000347 ! THO complex is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0000447 name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A2" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000448 name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:0000490 def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "cleavage at C2" RELATED [] synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000449 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000450 name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000451 name: rRNA 2'-O-methylation namespace: biological_process def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0000452 name: snoRNA guided rRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337] synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000453 name: enzyme-directed rRNA 2'-O-methylation namespace: biological_process def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000454 name: snoRNA guided rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000455 name: enzyme-directed rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000456 name: dimethylation involved in SSU-rRNA maturation namespace: biological_process def: "Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337] is_a: GO:0031167 ! rRNA methylation relationship: part_of GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000457 name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000458 name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000459 name: exonucleolytic trimming involved in rRNA processing namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic [Term] id: GO:0000460 name: maturation of 5.8S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000461 name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at site D" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000462 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:1990041 def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] synonym: "maturation of 18S rRNA" NARROW [] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000463 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000464 name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at A3" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000465 name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000466 name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000467 name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000468 name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] synonym: "processing at B2" NARROW [] is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000469 name: cleavage involved in rRNA processing namespace: biological_process def: "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis relationship: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000470 name: maturation of LSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000471 name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000472 name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A1" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000473 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000474 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000475 name: maturation of 2S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000476 name: maturation of 4.5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000477 name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "processing at C1" NARROW [] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000478 name: endonucleolytic cleavage involved in rRNA processing namespace: biological_process def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic [Term] id: GO:0000479 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000480 name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] synonym: "endonucleolytic cleavage at A0" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000481 name: maturation of 5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000482 name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000481 ! maturation of 5S rRNA [Term] id: GO:0000483 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000484 name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000485 name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA [Term] id: GO:0000486 name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000487 name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000488 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000489 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000491 name: small nucleolar ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "snoRNP assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0000492 name: box C/D snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000493 name: box H/ACA snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000494 name: box C/D snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc] synonym: "box C/D snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0000495 name: box H/ACA snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] synonym: "box H/ACA snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0000496 name: base pairing namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: Wikipedia:Base_pair is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0000497 name: base pairing with DNA namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000496 ! base pairing is_a: GO:0003677 ! DNA binding [Term] id: GO:0000498 name: base pairing with RNA namespace: molecular_function def: "Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000496 ! base pairing is_a: GO:0003723 ! RNA binding [Term] id: GO:0000499 name: base pairing with mRNA namespace: molecular_function def: "Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0000500 name: RNA polymerase I upstream activating factor complex namespace: cellular_component def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] synonym: "RNA polymerase I upstream activation factor complex" EXACT [] synonym: "UAF" EXACT [] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0000501 name: flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The non-sexual aggregation of cells mediated by protein (flocculin)-carbohydrate interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae." [DOI:10.1016/S0963-9969(99)00021-6, GOC:mcc, GOC:sgd_curators, GOC:vw] subset: gosubset_prok is_a: GO:0000128 ! flocculation [Term] id: GO:0000502 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb] subset: goslim_pir synonym: "26S proteasome" NARROW [] synonym: "proteasome" EXACT [GOC:cjm] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000504 name: proteasome regulatory particle (sensu Bacteria) namespace: cellular_component def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. synonym: "26S proteasome" NARROW [] is_obsolete: true [Term] id: GO:0000506 name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. synonym: "GPI-GlcNAc transferase complex" EXACT [] synonym: "GPI-GnT complex" EXACT [] synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0000578 name: embryonic axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] synonym: "embryonic axis determination" RELATED [] is_a: GO:0009798 ! axis specification is_a: GO:0009880 ! embryonic pattern specification [Term] id: GO:0000700 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000701 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2.- is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0000702 name: oxidized base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000703 name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0019004 def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. subset: gosubset_prok synonym: "bifunctional DNA glycosylase" BROAD [] synonym: "DNA glycosylase/AP-lyase" BROAD [] synonym: "DNA glycosylase/beta-lyase" BROAD [] synonym: "endodeoxyribonuclease III" RELATED [] synonym: "endonuclease III" RELATED [] synonym: "endonuclease VIII activity" RELATED [] synonym: "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT [GOC:go_curators] synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: Reactome:REACT_101001 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Plasmodium falciparum" xref: Reactome:REACT_101090 "Cleavage of dihydrouracil by hNTH1 glycosylase, Escherichia coli" xref: Reactome:REACT_101315 "Cleavage of cytosine glycol by hNTH1 glycosylase, Danio rerio" xref: Reactome:REACT_101744 "Cleavage of thymine glycol by hNTH1 glycosylase, Mus musculus" xref: Reactome:REACT_102306 "Cleavage of cytosine glycol by hNTH1 glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_103688 "Cleavage of thymine glycol by hNTH1 glycosylase, Gallus gallus" xref: Reactome:REACT_103837 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Saccharomyces cerevisiae" xref: Reactome:REACT_104179 "Cleavage of cytosine glycol by hNTH1 glycosylase, Oryza sativa" xref: Reactome:REACT_104266 "Cleavage of thymine glycol by hNTH1 glycosylase, Saccharomyces cerevisiae" xref: Reactome:REACT_104313 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_105538 "Cleavage of cytosine glycol by hNTH1 glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_105622 "Cleavage of thymine glycol by hNTH1 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_105635 "Cleavage of cytosine glycol by hNTH1 glycosylase, Escherichia coli" xref: Reactome:REACT_105967 "Cleavage of thymine glycol by hNTH1 glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_106253 "Cleavage of thymine glycol by hNTH1 glycosylase, Taeniopygia guttata" xref: Reactome:REACT_107207 "Cleavage of cytosine glycol by hNTH1 glycosylase, Bos taurus" xref: Reactome:REACT_107703 "Cleavage of dihydrouracil by hNTH1 glycosylase, Taeniopygia guttata" xref: Reactome:REACT_107763 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Danio rerio" xref: Reactome:REACT_108637 "Cleavage of cytosine glycol by hNTH1 glycosylase, Canis familiaris" xref: Reactome:REACT_108860 "Cleavage of dihydrouracil by hNTH1 glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_109023 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Bos taurus" xref: Reactome:REACT_109743 "Cleavage of cytosine glycol by hNTH1 glycosylase, Gallus gallus" xref: Reactome:REACT_2021 "Cleavage of cytosine glycol by hNTH1 glycosylase, Homo sapiens" xref: Reactome:REACT_2157 "Cleavage of dihydrouracil by hNTH1 glycosylase, Homo sapiens" xref: Reactome:REACT_2255 "Cleavage of thymine glycol by hNTH1 glycosylase, Homo sapiens" xref: Reactome:REACT_28127 "Cleavage of cytosine glycol by hNTH1 glycosylase, Mus musculus" xref: Reactome:REACT_28180 "Cleavage of thymine glycol by hNTH1 glycosylase, Caenorhabditis elegans" xref: Reactome:REACT_29323 "Cleavage of dihydrouracil by hNTH1 glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_29518 "Cleavage of cytosine glycol by hNTH1 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_30621 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Mus musculus" xref: Reactome:REACT_30642 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Oryza sativa" xref: Reactome:REACT_30750 "Cleavage of dihydrouracil by hNTH1 glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_32240 "Cleavage of cytosine glycol by hNTH1 glycosylase, Drosophila melanogaster" xref: Reactome:REACT_32421 "Cleavage of thymine glycol by hNTH1 glycosylase, Danio rerio" xref: Reactome:REACT_32931 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Escherichia coli" xref: Reactome:REACT_33078 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Taeniopygia guttata" xref: Reactome:REACT_33307 "Cleavage of cytosine glycol by hNTH1 glycosylase, Dictyostelium discoideum" xref: Reactome:REACT_33417 "Cleavage of cytosine glycol by hNTH1 glycosylase, Plasmodium falciparum" xref: Reactome:REACT_33820 "Cleavage of thymine glycol by hNTH1 glycosylase, Bos taurus" xref: Reactome:REACT_33839 "Cleavage of thymine glycol by hNTH1 glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_33951 "Cleavage of dihydrouracil by hNTH1 glycosylase, Drosophila melanogaster" xref: Reactome:REACT_34296 "Cleavage of dihydrouracil by hNTH1 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_77336 "Cleavage of cytosine glycol by hNTH1 glycosylase, Rattus norvegicus" xref: Reactome:REACT_77526 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Dictyostelium discoideum" xref: Reactome:REACT_78108 "Cleavage of cytosine glycol by hNTH1 glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_78298 "Cleavage of dihydrouracil by hNTH1 glycosylase, Saccharomyces cerevisiae" xref: Reactome:REACT_78343 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Sus scrofa" xref: Reactome:REACT_78458 "Cleavage of dihydrouracil by hNTH1 glycosylase, Danio rerio" xref: Reactome:REACT_78529 "Cleavage of dihydrouracil by hNTH1 glycosylase, Gallus gallus" xref: Reactome:REACT_79663 "Cleavage of dihydrouracil by hNTH1 glycosylase, Dictyostelium discoideum" xref: Reactome:REACT_79864 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_80155 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_81464 "Cleavage of dihydrouracil by hNTH1 glycosylase, Rattus norvegicus" xref: Reactome:REACT_81531 "Cleavage of thymine glycol by hNTH1 glycosylase, Oryza sativa" xref: Reactome:REACT_82850 "Cleavage of dihydrouracil by hNTH1 glycosylase, Sus scrofa" xref: Reactome:REACT_83701 "Cleavage of thymine glycol by hNTH1 glycosylase, Dictyostelium discoideum" xref: Reactome:REACT_83784 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Gallus gallus" xref: Reactome:REACT_84042 "Cleavage of dihydrouracil by hNTH1 glycosylase, Plasmodium falciparum" xref: Reactome:REACT_84141 "Cleavage of cytosine glycol by hNTH1 glycosylase, Caenorhabditis elegans" xref: Reactome:REACT_84471 "Cleavage of dihydrouracil by hNTH1 glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_85485 "Cleavage of dihydrouracil by hNTH1 glycosylase, Oryza sativa" xref: Reactome:REACT_87055 "Cleavage of cytosine glycol by hNTH1 glycosylase, Saccharomyces cerevisiae" xref: Reactome:REACT_87146 "Cleavage of cytosine glycol by hNTH1 glycosylase, Sus scrofa" xref: Reactome:REACT_87389 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Caenorhabditis elegans" xref: Reactome:REACT_87494 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_87850 "Cleavage of thymine glycol by hNTH1 glycosylase, Rattus norvegicus" xref: Reactome:REACT_87925 "Cleavage of dihydrouracil by hNTH1 glycosylase, Caenorhabditis elegans" xref: Reactome:REACT_890 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Homo sapiens" xref: Reactome:REACT_89137 "Cleavage of dihydrouracil by hNTH1 glycosylase, Bos taurus" xref: Reactome:REACT_89396 "Cleavage of cytosine glycol by hNTH1 glycosylase, Taeniopygia guttata" xref: Reactome:REACT_90163 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Drosophila melanogaster" xref: Reactome:REACT_90552 "Cleavage of thymine glycol by hNTH1 glycosylase, Canis familiaris" xref: Reactome:REACT_92193 "Cleavage of dihydrouracil by hNTH1 glycosylase, Canis familiaris" xref: Reactome:REACT_92466 "Cleavage of cytosine glycol by hNTH1 glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_93244 "Cleavage of thymine glycol by hNTH1 glycosylase, Sus scrofa" xref: Reactome:REACT_93473 "Cleavage of dihydrouracil by hNTH1 glycosylase, Mus musculus" xref: Reactome:REACT_94304 "Cleavage of thymine glycol by hNTH1 glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_95145 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Rattus norvegicus" xref: Reactome:REACT_96277 "Cleavage of thymine glycol by hNTH1 glycosylase, Escherichia coli" xref: Reactome:REACT_96754 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_97913 "Cleavage of thymine glycol by hNTH1 glycosylase, Drosophila melanogaster" xref: Reactome:REACT_97922 "Cleavage of thymine glycol by hNTH1 glycosylase, Plasmodium falciparum" xref: Reactome:REACT_98089 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Canis familiaris" xref: Reactome:REACT_99032 "Cleavage of thymine glycol by hNTH1 glycosylase, Mycobacterium tuberculosis" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity [Term] id: GO:0000704 name: pyrimidine dimer DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000705 name: achiasmate meiosis I namespace: biological_process def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] is_a: GO:0007127 ! meiosis I [Term] id: GO:0000706 name: meiotic DNA double-strand break processing namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000707 name: meiotic DNA recombinase assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000708 name: meiotic strand invasion namespace: biological_process def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] synonym: "meiotic D-loop biosynthesis" RELATED [] synonym: "meiotic D-loop formation" RELATED [] synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw] is_a: GO:0022402 ! cell cycle process is_a: GO:0042148 ! strand invasion is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000709 name: meiotic joint molecule formation namespace: biological_process def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000710 name: meiotic mismatch repair namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] is_a: GO:0006298 ! mismatch repair is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000711 name: meiotic DNA repair synthesis namespace: biological_process def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000712 name: resolution of meiotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] synonym: "crossover biosynthesis" NARROW [] synonym: "crossover formation" NARROW [] synonym: "formation of chiasmata" NARROW [] synonym: "homologous chromosome separation at meiosis I" EXACT [] synonym: "meiotic homologous chromosome separation" RELATED [] synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah] is_a: GO:0051307 ! meiotic chromosome separation relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000713 name: meiotic heteroduplex formation namespace: biological_process def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] is_a: GO:0022402 ! cell cycle process is_a: GO:0030491 ! heteroduplex formation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0006310 ! DNA recombination relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000714 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0000732 ! strand displacement is_a: GO:0022402 ! cell cycle process is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000715 name: nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] xref: Reactome:REACT_107456 "DNA Damage Recognition in GG-NER, Drosophila melanogaster" xref: Reactome:REACT_112311 "DNA Damage Recognition in GG-NER, Caenorhabditis elegans" xref: Reactome:REACT_115249 "DNA Damage Recognition in GG-NER, Xenopus tropicalis" xref: Reactome:REACT_115544 "DNA damage recognition in global genomic repair, Gallus gallus" xref: Reactome:REACT_29640 "DNA Damage Recognition in GG-NER, Dictyostelium discoideum" xref: Reactome:REACT_30130 "DNA Damage Recognition in GG-NER, Rattus norvegicus" xref: Reactome:REACT_31764 "DNA Damage Recognition in GG-NER, Taeniopygia guttata" xref: Reactome:REACT_476 "DNA Damage Recognition in GG-NER, Homo sapiens" xref: Reactome:REACT_77558 "DNA Damage Recognition in GG-NER, Danio rerio" xref: Reactome:REACT_81184 "DNA Damage Recognition in GG-NER, Bos taurus" xref: Reactome:REACT_82635 "DNA Damage Recognition in GG-NER, Canis familiaris" xref: Reactome:REACT_86796 "DNA Damage Recognition in GG-NER, Gallus gallus" xref: Reactome:REACT_89770 "DNA Damage Recognition in GG-NER, Arabidopsis thaliana" xref: Reactome:REACT_92224 "DNA Damage Recognition in GG-NER, Mus musculus" xref: Reactome:REACT_94418 "DNA Damage Recognition in GG-NER, Sus scrofa" xref: Reactome:REACT_95988 "DNA Damage Recognition in GG-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_97740 "DNA Damage Recognition in GG-NER, Oryza sativa" xref: Reactome:REACT_98000 "DNA Damage Recognition in GG-NER, Schizosaccharomyces pombe" is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000716 name: transcription-coupled nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] xref: Reactome:REACT_100470 "RNA Pol II is blocked by the lesion leading to reduced transcription, Plasmodium falciparum" xref: Reactome:REACT_100673 "RNA Pol II is blocked by the lesion leading to reduced transcription, Dictyostelium discoideum" xref: Reactome:REACT_100817 "RNA Pol II is blocked by the lesion leading to reduced transcription, Mus musculus" xref: Reactome:REACT_101583 "RNA Pol II is blocked by the lesion leading to reduced transcription, Drosophila melanogaster" xref: Reactome:REACT_103224 "RNA Pol II is blocked by the lesion leading to reduced transcription, Saccharomyces cerevisiae" xref: Reactome:REACT_104426 "RNA Pol II is blocked by the lesion leading to reduced transcription, Oryza sativa" xref: Reactome:REACT_106854 "RNA Pol II is blocked by the lesion leading to reduced transcription, Schizosaccharomyces pombe" xref: Reactome:REACT_1947 "RNA Pol II is blocked by the lesion leading to reduced transcription, Homo sapiens" xref: Reactome:REACT_78581 "RNA Pol II is blocked by the lesion leading to reduced transcription, Gallus gallus" xref: Reactome:REACT_78888 "RNA Pol II is blocked by the lesion leading to reduced transcription, Canis familiaris" xref: Reactome:REACT_80099 "RNA Pol II is blocked by the lesion leading to reduced transcription, Xenopus tropicalis" xref: Reactome:REACT_86060 "RNA Pol II is blocked by the lesion leading to reduced transcription, Bos taurus" xref: Reactome:REACT_86572 "RNA Pol II is blocked by the lesion leading to reduced transcription, Taeniopygia guttata" xref: Reactome:REACT_86848 "RNA Pol II is blocked by the lesion leading to reduced transcription, Caenorhabditis elegans" xref: Reactome:REACT_88150 "RNA Pol II is blocked by the lesion leading to reduced transcription, Danio rerio" xref: Reactome:REACT_90318 "RNA Pol II is blocked by the lesion leading to reduced transcription, Arabidopsis thaliana" xref: Reactome:REACT_96982 "RNA Pol II is blocked by the lesion leading to reduced transcription, Rattus norvegicus" is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair [Term] id: GO:0000717 name: nucleotide-excision repair, DNA duplex unwinding namespace: biological_process def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus" xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa" xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens" xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata" xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus" xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio" xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans" xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis" xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus" xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster" xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris" xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus" xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae" xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana" xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa" is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000718 name: nucleotide-excision repair, DNA damage removal namespace: biological_process def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:REACT_102444 "Dual incision reaction in GG-NER, Oryza sativa" xref: Reactome:REACT_104645 "Dual incision reaction in GG-NER, Taeniopygia guttata" xref: Reactome:REACT_109019 "Dual incision reaction in GG-NER, Bos taurus" xref: Reactome:REACT_30192 "Dual incision reaction in GG-NER, Xenopus tropicalis" xref: Reactome:REACT_311 "Dual incision reaction in GG-NER, Homo sapiens" xref: Reactome:REACT_31322 "Dual incision reaction in GG-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_32014 "Dual incision reaction in GG-NER, Danio rerio" xref: Reactome:REACT_52725 "Dual incision reaction in GG-NER, Gallus gallus" xref: Reactome:REACT_89200 "Dual incision reaction in GG-NER, Sus scrofa" xref: Reactome:REACT_90961 "Dual incision reaction in GG-NER, Arabidopsis thaliana" xref: Reactome:REACT_91383 "Dual incision reaction in GG-NER, Drosophila melanogaster" xref: Reactome:REACT_92216 "Dual incision reaction in GG-NER, Canis familiaris" xref: Reactome:REACT_92900 "Dual incision reaction in GG-NER, Rattus norvegicus" xref: Reactome:REACT_93068 "Dual incision reaction in GG-NER, Schizosaccharomyces pombe" xref: Reactome:REACT_96787 "Dual incision reaction in GG-NER, Caenorhabditis elegans" xref: Reactome:REACT_99802 "Dual incision reaction in GG-NER, Mus musculus" is_a: GO:0006308 ! DNA catabolic process is_a: GO:0044349 ! DNA excision relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000719 name: photoreactive repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] subset: gosubset_prok synonym: "pyrimidine-dimer repair by photolyase" NARROW [] is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000720 name: pyrimidine dimer repair by nucleotide-excision repair namespace: biological_process def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. subset: gosubset_prok is_a: GO:0006289 ! nucleotide-excision repair is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000721 name: (R,R)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+)." [EC:1.1.1.4] subset: gosubset_prok synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] xref: EC:1.1.1.4 xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN xref: RHEA:24343 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000722 name: telomere maintenance via recombination namespace: biological_process def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] synonym: "telomerase-independent telomere maintenance" RELATED [] xref: Reactome:REACT_101373 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_101439 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Danio rerio" xref: Reactome:REACT_101498 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Oryza sativa" xref: Reactome:REACT_101756 "Polymerase switching on the C-strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_101953 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Oryza sativa" xref: Reactome:REACT_102170 "Polymerase switching on the C-strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_102248 "RPA binds to the Flap on the C-strand, Danio rerio" xref: Reactome:REACT_102860 "Polymerase switching on the C-strand of the telomere, Canis familiaris" xref: Reactome:REACT_102881 "Removal of the Flap Intermediate from the C-strand, Oryza sativa" xref: Reactome:REACT_103207 "Telomere C-strand synthesis initiation, Dictyostelium discoideum" xref: Reactome:REACT_103350 "Telomere C-strand synthesis initiation, Schizosaccharomyces pombe" xref: Reactome:REACT_103501 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_103857 "Recruitment of Dna2 endonuclease to the C strand, Sus scrofa" xref: Reactome:REACT_104171 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Danio rerio" xref: Reactome:REACT_104453 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_104638 "Polymerase switching on the C-strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_105177 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Mus musculus" xref: Reactome:REACT_105258 "Formation of Processive Complex on the C-strand of the telomere, Mus musculus" xref: Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa" xref: Reactome:REACT_105491 "Formation of Processive Complex on the C-strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_106206 "Removal of the Flap Intermediate from the C-strand, Schizosaccharomyces pombe" xref: Reactome:REACT_106874 "Polymerase switching on the C-strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_106919 "Joining of adjacent Okazaki fragments of the C-strand, Oryza sativa" xref: Reactome:REACT_106924 "Removal of remaining Flap from the C-strand, Bos taurus" xref: Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe" xref: Reactome:REACT_107163 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_107299 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Gallus gallus" xref: Reactome:REACT_107682 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_108058 "Formation of Processive Complex on the C-strand of the telomere, Oryza sativa" xref: Reactome:REACT_108279 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_108285 "Processive synthesis on the C-strand of the telomere, Oryza sativa" xref: Reactome:REACT_108323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_108876 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_109084 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Bos taurus" xref: Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus" xref: Reactome:REACT_109676 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Bos taurus" xref: Reactome:REACT_110206 "Recruitment of Dna2 endonuclease to the C strand, Canis familiaris" xref: Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris" xref: Reactome:REACT_110586 "Removal of remaining Flap from the C-strand, Xenopus tropicalis" xref: Reactome:REACT_110741 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_28301 "Removal of remaining Flap from the C-strand, Danio rerio" xref: Reactome:REACT_28337 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_28438 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Danio rerio" xref: Reactome:REACT_28735 "Formation of the Flap Intermediate on the C-strand, Oryza sativa" xref: Reactome:REACT_28845 "Removal of the Flap Intermediate from the C-strand, Xenopus tropicalis" xref: Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio" xref: Reactome:REACT_29091 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Danio rerio" xref: Reactome:REACT_29268 "Polymerase switching on the C-strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_29498 "Joining of adjacent Okazaki fragments of the C-strand, Mus musculus" xref: Reactome:REACT_29561 "Telomere C-strand synthesis initiation, Caenorhabditis elegans" xref: Reactome:REACT_29730 "Processive synthesis on the C-strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_29736 "Removal of remaining Flap from the C-strand, Oryza sativa" xref: Reactome:REACT_30132 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_30146 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Canis familiaris" xref: Reactome:REACT_30357 "Recruitment of Dna2 endonuclease to the C strand, Oryza sativa" xref: Reactome:REACT_30676 "Processive synthesis on the C-strand of the telomere, Taeniopygia guttata" xref: Reactome:REACT_31415 "Polymerase switching on the C-strand of the telomere, Gallus gallus" xref: Reactome:REACT_31855 "Recruitment of Dna2 endonuclease to the C strand, Xenopus tropicalis" xref: Reactome:REACT_31896 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Mus musculus" xref: Reactome:REACT_32409 "Formation of Processive Complex on the C-strand of the telomere, Bos taurus" xref: Reactome:REACT_32656 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Oryza sativa" xref: Reactome:REACT_32714 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_32801 "Recruitment of Dna2 endonuclease to the C strand, Schizosaccharomyces pombe" xref: Reactome:REACT_33015 "Formation of the Flap Intermediate on the C-strand, Sus scrofa" xref: Reactome:REACT_33071 "Polymerase switching on the C-strand of the telomere, Bos taurus" xref: Reactome:REACT_33514 "Recruitment of Dna2 endonuclease to the C strand, Danio rerio" xref: Reactome:REACT_33663 "Processive synthesis on the C-strand of the telomere, Mus musculus" xref: Reactome:REACT_33974 "Formation of the Flap Intermediate on the C-strand, Mus musculus" xref: Reactome:REACT_34757 "Polymerase switching on the C-strand of the telomere, Taeniopygia guttata" xref: Reactome:REACT_57279 "Processive synthesis on the C-strand of the telomere, Bos taurus" xref: Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa" xref: Reactome:REACT_77820 "Formation of Processive Complex on the C-strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_77906 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_78056 "Formation of the Flap Intermediate on the C-strand, Rattus norvegicus" xref: Reactome:REACT_78182 "Telomere C-strand synthesis initiation, Rattus norvegicus" xref: Reactome:REACT_78501 "Formation of the Flap Intermediate on the C-strand, Bos taurus" xref: Reactome:REACT_78969 "Joining of adjacent Okazaki fragments of the C-strand, Bos taurus" xref: Reactome:REACT_79008 "Recruitment of Dna2 endonuclease to the C strand, Arabidopsis thaliana" xref: Reactome:REACT_79101 "Removal of the Flap Intermediate from the C-strand, Danio rerio" xref: Reactome:REACT_7949 "RPA binds to the Flap on the C-strand, Homo sapiens" xref: Reactome:REACT_7955 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Homo sapiens" xref: Reactome:REACT_7967 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Homo sapiens" xref: Reactome:REACT_7973 "Formation of the Flap Intermediate on the C-strand, Homo sapiens" xref: Reactome:REACT_7975 "Removal of remaining Flap from the C-strand, Homo sapiens" xref: Reactome:REACT_7979 "Formation of Processive Complex on the C-strand of the telomere, Homo sapiens" xref: Reactome:REACT_7987 "Polymerase switching on the C-strand of the telomere, Homo sapiens" xref: Reactome:REACT_7993 "Telomere C-strand synthesis initiation, Homo sapiens" xref: Reactome:REACT_7994 "Joining of adjacent Okazaki fragments of the C-strand, Homo sapiens" xref: Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_7998 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Homo sapiens" xref: Reactome:REACT_7999 "Removal of the Flap Intermediate from the C-strand, Homo sapiens" xref: Reactome:REACT_8000 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Homo sapiens" xref: Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Homo sapiens" xref: Reactome:REACT_8008 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Homo sapiens" xref: Reactome:REACT_8015 "Recruitment of Dna2 endonuclease to the C strand, Homo sapiens" xref: Reactome:REACT_80165 "Removal of the Flap Intermediate from the C-strand, Taeniopygia guttata" xref: Reactome:REACT_8027 "Processive synthesis on the C-strand of the telomere, Homo sapiens" xref: Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens" xref: Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_80567 "Polymerase switching on the C-strand of the telomere, Mus musculus" xref: Reactome:REACT_80653 "Telomere C-strand synthesis initiation, Sus scrofa" xref: Reactome:REACT_80757 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_80999 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_81201 "Removal of remaining Flap from the C-strand, Mus musculus" xref: Reactome:REACT_81258 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_81387 "Formation of Processive Complex on the C-strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_81697 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Taeniopygia guttata" xref: Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Sus scrofa" xref: Reactome:REACT_81990 "Joining of adjacent Okazaki fragments of the C-strand, Danio rerio" xref: Reactome:REACT_82014 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_82097 "Processive synthesis on the C-strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_82465 "Processive synthesis on the C-strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_82605 "Telomere C-strand synthesis initiation, Canis familiaris" xref: Reactome:REACT_82834 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Canis familiaris" xref: Reactome:REACT_83118 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_83299 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Danio rerio" xref: Reactome:REACT_83482 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Xenopus tropicalis" xref: Reactome:REACT_83617 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Oryza sativa" xref: Reactome:REACT_83805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_84276 "Recruitment of Dna2 endonuclease to the C strand, Taeniopygia guttata" xref: Reactome:REACT_84292 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Bos taurus" xref: Reactome:REACT_84527 "Joining of adjacent Okazaki fragments of the C-strand, Xenopus tropicalis" xref: Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Mus musculus" xref: Reactome:REACT_85303 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_85614 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Rattus norvegicus" xref: Reactome:REACT_85781 "Joining of adjacent Okazaki fragments of the C-strand, Schizosaccharomyces pombe" xref: Reactome:REACT_85910 "Joining of adjacent Okazaki fragments of the C-strand, Canis familiaris" xref: Reactome:REACT_85945 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_86438 "Removal of the Flap Intermediate from the C-strand, Mus musculus" xref: Reactome:REACT_86551 "Formation of the Flap Intermediate on the C-strand, Danio rerio" xref: Reactome:REACT_86566 "RPA binds to the Flap on the C-strand, Mus musculus" xref: Reactome:REACT_86673 "Processive synthesis on the C-strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_86894 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Bos taurus" xref: Reactome:REACT_87128 "Processive synthesis on the C-strand of the telomere, Canis familiaris" xref: Reactome:REACT_87148 "Recruitment of Dna2 endonuclease to the C strand, Rattus norvegicus" xref: Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_87564 "Recruitment of Dna2 endonuclease to the C strand, Mus musculus" xref: Reactome:REACT_87776 "Removal of the Flap Intermediate from the C-strand, Canis familiaris" xref: Reactome:REACT_87852 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Canis familiaris" xref: Reactome:REACT_87982 "Removal of the Flap Intermediate from the C-strand, Arabidopsis thaliana" xref: Reactome:REACT_88080 "Telomere C-strand synthesis initiation, Mus musculus" xref: Reactome:REACT_88200 "Formation of the Flap Intermediate on the C-strand, Canis familiaris" xref: Reactome:REACT_88586 "RPA binds to the Flap on the C-strand, Rattus norvegicus" xref: Reactome:REACT_88760 "Removal of remaining Flap from the C-strand, Sus scrofa" xref: Reactome:REACT_88793 "RPA binds to the Flap on the C-strand, Bos taurus" xref: Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Danio rerio" xref: Reactome:REACT_89109 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Canis familiaris" xref: Reactome:REACT_89136 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_89422 "RPA binds to the Flap on the C-strand, Xenopus tropicalis" xref: Reactome:REACT_89618 "Joining of adjacent Okazaki fragments of the C-strand, Rattus norvegicus" xref: Reactome:REACT_89731 "Polymerase switching on the C-strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_89859 "Polymerase switching on the C-strand of the telomere, Danio rerio" xref: Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus" xref: Reactome:REACT_90432 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_90507 "Polymerase switching on the C-strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_90656 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_91185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Bos taurus" xref: Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Oryza sativa" xref: Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus" xref: Reactome:REACT_91568 "Recruitment of Dna2 endonuclease to the C strand, Bos taurus" xref: Reactome:REACT_91624 "Telomere C-strand synthesis initiation, Saccharomyces cerevisiae" xref: Reactome:REACT_91633 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Gallus gallus" xref: Reactome:REACT_91661 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_92017 "Telomere C-strand synthesis initiation, Arabidopsis thaliana" xref: Reactome:REACT_92092 "Joining of adjacent Okazaki fragments of the C-strand, Sus scrofa" xref: Reactome:REACT_92189 "Processive synthesis on the C-strand of the telomere, Danio rerio" xref: Reactome:REACT_92339 "Removal of remaining Flap from the C-strand, Rattus norvegicus" xref: Reactome:REACT_92420 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Sus scrofa" xref: Reactome:REACT_92505 "Removal of the Flap Intermediate from the C-strand, Rattus norvegicus" xref: Reactome:REACT_92773 "Formation of Processive Complex on the C-strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_93121 "Polymerase switching on the C-strand of the telomere, Sus scrofa" xref: Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana" xref: Reactome:REACT_93603 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Taeniopygia guttata" xref: Reactome:REACT_93674 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_93682 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_93745 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Canis familiaris" xref: Reactome:REACT_93893 "Removal of the Flap Intermediate from the C-strand, Bos taurus" xref: Reactome:REACT_94317 "Joining of adjacent Okazaki fragments of the C-strand, Arabidopsis thaliana" xref: Reactome:REACT_94323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Canis familiaris" xref: Reactome:REACT_94685 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_94878 "Formation of the Flap Intermediate on the C-strand, Xenopus tropicalis" xref: Reactome:REACT_94930 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_95256 "Polymerase switching on the C-strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_95355 "Polymerase switching on the C-strand of the telomere, Oryza sativa" xref: Reactome:REACT_95570 "RPA binds to the Flap on the C-strand, Canis familiaris" xref: Reactome:REACT_95593 "Telomere C-strand synthesis initiation, Bos taurus" xref: Reactome:REACT_95767 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_95954 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Mus musculus" xref: Reactome:REACT_96276 "Removal of remaining Flap from the C-strand, Schizosaccharomyces pombe" xref: Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_96454 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_96676 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Mus musculus" xref: Reactome:REACT_96810 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Bos taurus" xref: Reactome:REACT_97146 "Removal of remaining Flap from the C-strand, Arabidopsis thaliana" xref: Reactome:REACT_97211 "Telomere C-strand synthesis initiation, Drosophila melanogaster" xref: Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis" xref: Reactome:REACT_97574 "Formation of the Flap Intermediate on the C-strand, Arabidopsis thaliana" xref: Reactome:REACT_97781 "Telomere C-strand synthesis initiation, Danio rerio" xref: Reactome:REACT_97849 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_98163 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Mus musculus" xref: Reactome:REACT_98508 "Telomere C-strand synthesis initiation, Oryza sativa" xref: Reactome:REACT_98514 "Telomere C-strand synthesis initiation, Xenopus tropicalis" xref: Reactome:REACT_98606 "Formation of Processive Complex on the C-strand of the telomere, Danio rerio" xref: Reactome:REACT_98653 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_98674 "Formation of Processive Complex on the C-strand of the telomere, Canis familiaris" xref: Reactome:REACT_98759 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_98885 "Formation of the Flap Intermediate on the C-strand, Schizosaccharomyces pombe" xref: Reactome:REACT_99121 "Removal of the Flap Intermediate from the C-strand, Sus scrofa" xref: Reactome:REACT_99658 "Processive synthesis on the C-strand of the telomere, Sus scrofa" xref: Reactome:REACT_99801 "Polymerase switching on the C-strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_99836 "Telomere C-strand synthesis initiation, Plasmodium falciparum" is_a: GO:0000723 ! telomere maintenance is_a: GO:0006312 ! mitotic recombination [Term] id: GO:0000723 name: telomere maintenance namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] xref: Reactome:REACT_102051 "Telomere Maintenance, Sus scrofa" xref: Reactome:REACT_102166 "Telomere Maintenance, Schizosaccharomyces pombe" xref: Reactome:REACT_103257 "Telomere Maintenance, Bos taurus" xref: Reactome:REACT_103618 "Telomere Maintenance, Canis familiaris" xref: Reactome:REACT_104398 "Telomere Maintenance, Dictyostelium discoideum" xref: Reactome:REACT_105276 "Disassociation of Processive Complex and Completed Telomere End, Canis familiaris" xref: Reactome:REACT_105401 "Packaging Of Telomere Ends, Rattus norvegicus" xref: Reactome:REACT_105641 "Disassociation of Processive Complex and Completed Telomere End, Mus musculus" xref: Reactome:REACT_107344 "Disassociation of Processive Complex and Completed Telomere End, Xenopus tropicalis" xref: Reactome:REACT_109055 "Disassociation of Processive Complex and Completed Telomere End, Schizosaccharomyces pombe" xref: Reactome:REACT_110319 "Telomere Maintenance, Rattus norvegicus" xref: Reactome:REACT_115102 "Packaging Of Telomere Ends, Canis familiaris" xref: Reactome:REACT_115503 "Packaging Of Telomere Ends, Danio rerio" xref: Reactome:REACT_115535 "Telomere maintenance, Gallus gallus" xref: Reactome:REACT_31996 "Disassociation of Processive Complex and Completed Telomere End, Rattus norvegicus" xref: Reactome:REACT_32322 "Packaging Of Telomere Ends, Sus scrofa" xref: Reactome:REACT_78001 "Telomere Maintenance, Danio rerio" xref: Reactome:REACT_78680 "Telomere Maintenance, Saccharomyces cerevisiae" xref: Reactome:REACT_7954 "Disassociation of Processive Complex and Completed Telomere End, Homo sapiens" xref: Reactome:REACT_7963 "Packaging Of Telomere Ends, Homo sapiens" xref: Reactome:REACT_7970 "Telomere Maintenance, Homo sapiens" xref: Reactome:REACT_80940 "Telomere Maintenance, Plasmodium falciparum" xref: Reactome:REACT_82431 "Disassociation of Processive Complex and Completed Telomere End, Danio rerio" xref: Reactome:REACT_83277 "Disassociation of Processive Complex and Completed Telomere End, Bos taurus" xref: Reactome:REACT_84888 "Telomere Maintenance, Mus musculus" xref: Reactome:REACT_85317 "Disassociation of Processive Complex and Completed Telomere End, Oryza sativa" xref: Reactome:REACT_85782 "Telomere Maintenance, Arabidopsis thaliana" xref: Reactome:REACT_86038 "Telomere Maintenance, Drosophila melanogaster" xref: Reactome:REACT_86194 "Disassociation of Processive Complex and Completed Telomere End, Arabidopsis thaliana" xref: Reactome:REACT_87184 "Telomere Maintenance, Caenorhabditis elegans" xref: Reactome:REACT_88530 "Packaging Of Telomere Ends, Mus musculus" xref: Reactome:REACT_94176 "Telomere Maintenance, Gallus gallus" xref: Reactome:REACT_94707 "Telomere Maintenance, Oryza sativa" xref: Reactome:REACT_96013 "Telomere Maintenance, Taeniopygia guttata" xref: Reactome:REACT_96166 "Telomere Maintenance, Xenopus tropicalis" is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032200 ! telomere organization is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0000724 name: double-strand break repair via homologous recombination namespace: biological_process alt_id: GO:0016924 def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] subset: gosubset_prok synonym: "HDR" EXACT [GOC:vk] synonym: "homologous recombinational repair" EXACT [] synonym: "homology-directed repair" EXACT [GOC:vk] synonym: "HRR" EXACT [] synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] synonym: "Rhp51-dependent recombinational repair" EXACT [] xref: Reactome:REACT_103005 "Homologous Recombination Repair, Caenorhabditis elegans" xref: Reactome:REACT_108237 "Homologous Recombination Repair, Saccharomyces cerevisiae" xref: Reactome:REACT_115539 "Recruitment of repair and signaling proteins to double-strand breaks, Gallus gallus" xref: Reactome:REACT_115585 "Homologous recombination repair of replication-dependent double-strand breaks, Gallus gallus" xref: Reactome:REACT_115626 "Homologous DNA pairing and strand exchange, Gallus gallus" xref: Reactome:REACT_115651 "ATM mediated response to DNA double-strand break, Gallus gallus" xref: Reactome:REACT_115715 "ATM mediated phosphorylation of repair proteins, Gallus gallus" xref: Reactome:REACT_115769 "Homologous recombination repair, Gallus gallus" xref: Reactome:REACT_115931 "Processing of DNA double-strand break ends, Gallus gallus" xref: Reactome:REACT_115936 "Homologous recombination repair (HRR) of replication-independent double-strand breaks, Gallus gallus" xref: Reactome:REACT_1874 "Homologous Recombination Repair, Homo sapiens" xref: Reactome:REACT_29815 "Homologous Recombination Repair, Sus scrofa" xref: Reactome:REACT_33853 "Homologous Recombination Repair, Oryza sativa" xref: Reactome:REACT_42307 "Homologous Recombination Repair, Gallus gallus" xref: Reactome:REACT_80576 "Homologous Recombination Repair, Schizosaccharomyces pombe" xref: Reactome:REACT_82771 "Homologous Recombination Repair, Xenopus tropicalis" xref: Reactome:REACT_83941 "Homologous Recombination Repair, Plasmodium falciparum" xref: Reactome:REACT_84594 "Homologous Recombination Repair, Dictyostelium discoideum" xref: Reactome:REACT_84793 "Homologous Recombination Repair, Danio rerio" xref: Reactome:REACT_85965 "Homologous Recombination Repair, Drosophila melanogaster" xref: Reactome:REACT_87979 "Homologous Recombination Repair, Mycobacterium tuberculosis" xref: Reactome:REACT_90944 "Homologous Recombination Repair, Mus musculus" xref: Reactome:REACT_92384 "Homologous Recombination Repair, Canis familiaris" xref: Reactome:REACT_92897 "Homologous Recombination Repair, Arabidopsis thaliana" xref: Reactome:REACT_97339 "Homologous Recombination Repair, Taeniopygia guttata" xref: Reactome:REACT_99066 "Homologous Recombination Repair, Rattus norvegicus" xref: Reactome:REACT_99423 "Homologous Recombination Repair, Bos taurus" is_a: GO:0000725 ! recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0000725 name: recombinational repair namespace: biological_process def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok xref: Wikipedia:Recombinational_repair is_a: GO:0006281 ! DNA repair is_a: GO:0006310 ! DNA recombination [Term] id: GO:0000726 name: non-recombinational repair namespace: biological_process def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000727 name: double-strand break repair via break-induced replication namespace: biological_process def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] subset: gosubset_prok is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0000728 name: gene conversion at mating-type locus, DNA double-strand break formation namespace: biological_process def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000729 name: DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] xref: Reactome:REACT_172 "Resection of double-strand break ends, Homo sapiens" is_a: GO:0000738 ! DNA catabolic process, exonucleolytic relationship: part_of GO:0006302 ! double-strand break repair [Term] id: GO:0000730 name: DNA recombinase assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw] xref: Reactome:REACT_100225 "Assembly of the RAD51-ssDNA nucleoprotein complex, Gallus gallus" xref: Reactome:REACT_100616 "Assembly of the RAD51-ssDNA nucleoprotein complex, Plasmodium falciparum" xref: Reactome:REACT_101062 "Assembly of the RAD51-ssDNA nucleoprotein complex, Arabidopsis thaliana" xref: Reactome:REACT_102016 "Assembly of the RAD51-ssDNA nucleoprotein complex, Dictyostelium discoideum" xref: Reactome:REACT_103788 "Assembly of the RAD51-ssDNA nucleoprotein complex, Drosophila melanogaster" xref: Reactome:REACT_104366 "Assembly of the RAD51-ssDNA nucleoprotein complex, Schizosaccharomyces pombe" xref: Reactome:REACT_106498 "Assembly of the RAD51-ssDNA nucleoprotein complex, Taeniopygia guttata" xref: Reactome:REACT_110494 "Assembly of the RAD51-ssDNA nucleoprotein complex, Mus musculus" xref: Reactome:REACT_2141 "Assembly of the RAD51-ssDNA nucleoprotein complex, Homo sapiens" xref: Reactome:REACT_28107 "Assembly of the RAD51-ssDNA nucleoprotein complex, Saccharomyces cerevisiae" xref: Reactome:REACT_32257 "Assembly of the RAD51-ssDNA nucleoprotein complex, Bos taurus" xref: Reactome:REACT_78586 "Assembly of the RAD51-ssDNA nucleoprotein complex, Canis familiaris" xref: Reactome:REACT_79561 "Assembly of the RAD51-ssDNA nucleoprotein complex, Sus scrofa" xref: Reactome:REACT_81810 "Assembly of the RAD51-ssDNA nucleoprotein complex, Xenopus tropicalis" xref: Reactome:REACT_82066 "Assembly of the RAD51-ssDNA nucleoprotein complex, Caenorhabditis elegans" xref: Reactome:REACT_85201 "Assembly of the RAD51-ssDNA nucleoprotein complex, Oryza sativa" xref: Reactome:REACT_88197 "Assembly of the RAD51-ssDNA nucleoprotein complex, Rattus norvegicus" xref: Reactome:REACT_96901 "Assembly of the RAD51-ssDNA nucleoprotein complex, Danio rerio" is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0000731 name: DNA synthesis involved in DNA repair namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template." [PMID:10357855] subset: gosubset_prok synonym: "DNA repair synthesis" BROAD [] synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb] synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah] xref: Reactome:REACT_973 "DNA repair synthesis, Homo sapiens" is_a: GO:0071897 ! DNA biosynthetic process relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0000732 name: strand displacement namespace: biological_process def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] subset: gosubset_prok synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw] xref: Reactome:REACT_287 "Dissociation of the extended strands, Homo sapiens" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000733 name: DNA strand renaturation namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0000734 name: gene conversion at mating-type locus, DNA repair synthesis namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000735 name: removal of nonhomologous ends namespace: biological_process def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0000737 ! DNA catabolic process, endonucleolytic is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000736 name: double-strand break repair via single-strand annealing, removal of nonhomologous ends namespace: biological_process def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] subset: gosubset_prok is_a: GO:0000735 ! removal of nonhomologous ends relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0000737 name: DNA catabolic process, endonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] subset: gosubset_prok synonym: "DNA breakdown, endonucleolytic" EXACT [] synonym: "DNA degradation, endonucleolytic" EXACT [] synonym: "endonucleolytic degradation of DNA" EXACT [] synonym: "endonucleolytic DNA catabolism" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0000738 name: DNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] subset: gosubset_prok synonym: "DNA breakdown, exonucleolytic" EXACT [] synonym: "DNA degradation, exonucleolytic" EXACT [] synonym: "exonucleolytic degradation of DNA" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0000739 name: DNA strand annealing activity namespace: molecular_function def: "OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] comment: This term was made obsolete because it describes a process and not an activity. is_obsolete: true consider: GO:0000733 consider: GO:0036292 consider: GO:0036310 [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0000742 name: karyogamy involved in conjugation with cellular fusion namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000743 name: nuclear migration involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0006946 def: "The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt] synonym: "nuclear congression" BROAD [] synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000744 name: karyogamy involved in conjugation with mutual genetic exchange namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh] synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000745 name: nuclear migration involved in conjugation with mutual genetic exchange namespace: biological_process def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Conjugation is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0000746 ! conjugation is_a: GO:0019953 ! sexual reproduction [Term] id: GO:0000748 name: conjugation with mutual genetic exchange namespace: biological_process def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] synonym: "conjugation without cellular fusion" EXACT [] is_a: GO:0000746 ! conjugation [Term] id: GO:0000749 name: response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007328 alt_id: GO:0030434 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0071444 ! cellular response to pheromone relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000750 name: pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007330 alt_id: GO:0030454 def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "transduction of mating signal" BROAD [] is_a: GO:0007186 ! G-protein coupled receptor signaling pathway is_a: GO:0032005 ! signal transduction involved in conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000751 name: cell cycle arrest in response to pheromone namespace: biological_process alt_id: GO:0030571 def: "The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:tb] is_a: GO:0007050 ! cell cycle arrest is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000752 name: agglutination involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007334 def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] synonym: "agglutination" BROAD [] synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] synonym: "cell-cell adhesion during mating" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000753 name: cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007332 def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] synonym: "shmoo orientation" NARROW [] synonym: "shmooing" NARROW [] is_a: GO:0000767 ! cell morphogenesis involved in conjugation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000754 name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007331 alt_id: GO:0030453 def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] is_a: GO:0000749 ! response to pheromone involved in conjugation with cellular fusion is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0000755 name: cytogamy namespace: biological_process alt_id: GO:0000218 alt_id: GO:0030462 def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "zygote formation" RELATED [] is_a: GO:0022413 ! reproductive process in single-celled organism relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000756 name: response to pheromone involved in conjugation with mutual genetic exchange namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt] synonym: "response to pheromone involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007154 ! cell communication is_a: GO:0071444 ! cellular response to pheromone relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000757 name: signal transduction involved in conjugation with mutual genetic exchange namespace: biological_process def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor signaling pathway relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000758 name: agglutination involved in conjugation with mutual genetic exchange namespace: biological_process def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000771 ! agglutination involved in conjugation relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000759 name: cell morphogenesis involved in conjugation with mutual genetic exchange namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000767 ! cell morphogenesis involved in conjugation relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000760 name: adaptation to pheromone involved in conjugation with mutual genetic exchange namespace: biological_process def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] is_a: GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000761 name: conjugant formation namespace: biological_process def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000762 name: pheromone-induced unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] is_a: GO:0009291 ! unidirectional conjugation [Term] id: GO:0000763 name: cell morphogenesis involved in unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. is_obsolete: true [Term] id: GO:0000764 name: cellular morphogenesis involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0000765 name: response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation." [GOC:clt] synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_a: GO:0019236 ! response to pheromone relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0000766 name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] is_a: GO:0000765 ! response to pheromone involved in pheromone-induced unidirectional conjugation is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000767 name: cell morphogenesis involved in conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" EXACT [] is_a: GO:0006949 ! syncytium formation [Term] id: GO:0000769 name: syncytium formation by mitosis without cytokinesis namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb] synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah] is_a: GO:0006949 ! syncytium formation [Term] id: GO:0000770 name: peptide pheromone export namespace: biological_process alt_id: GO:0007325 def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] synonym: "a-factor export" NARROW [] is_a: GO:0009914 ! hormone transport is_a: GO:0015833 ! peptide transport [Term] id: GO:0000771 name: agglutination involved in conjugation namespace: biological_process def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] is_a: GO:0007157 ! heterophilic cell-cell adhesion relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000772 name: mating pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0000773 name: phosphatidyl-N-methylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] subset: gosubset_prok synonym: "methyltransferase II" RELATED [EC:2.1.1.71] synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: MetaCyc:2.1.1.71-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000774 name: adenyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] subset: gosubset_prok is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0000775 name: chromosome, centromeric region namespace: cellular_component def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "centromere" RELATED [] synonym: "chromosome, centric region" EXACT [] synonym: "chromosome, pericentric region" RELATED [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000776 name: kinetochore namespace: cellular_component alt_id: GO:0005699 def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. subset: goslim_pir xref: Wikipedia:Kinetochore is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0000777 name: condensed chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000776 ! kinetochore relationship: part_of GO:0000779 ! condensed chromosome, centromeric region [Term] id: GO:0000778 name: condensed nuclear chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000777 ! condensed chromosome kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region [Term] id: GO:0000779 name: condensed chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed chromosome, centric region" EXACT [] synonym: "condensed chromosome, centromere" RELATED [] synonym: "condensed chromosome, pericentric region" RELATED [] is_a: GO:0000775 ! chromosome, centromeric region relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000780 name: condensed nuclear chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed nuclear chromosome, centric region" EXACT [] synonym: "condensed nuclear chromosome, centromere" RELATED [] synonym: "condensed nuclear chromosome, pericentric region" RELATED [] is_a: GO:0000779 ! condensed chromosome, centromeric region is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000781 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000782 name: telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir subset: gosubset_prok is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0000783 name: nuclear telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. is_a: GO:0000782 ! telomere cap complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0000784 name: nuclear chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "nuclear chromosome, telomere" EXACT [] is_a: GO:0000781 ! chromosome, telomeric region is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] synonym: "chromosome scaffold" RELATED [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000786 name: nucleosome namespace: cellular_component alt_id: GO:0005718 def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] subset: goslim_pir xref: Wikipedia:Nucleosome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000785 ! chromatin [Term] id: GO:0000787 name: cytoplasmic nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000789 ! cytoplasmic chromatin [Term] id: GO:0000788 name: nuclear nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000789 name: cytoplasmic chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000790 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000793 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] is_a: GO:0005694 ! chromosome [Term] id: GO:0000794 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000793 ! condensed chromosome [Term] id: GO:0000795 name: synaptonemal complex namespace: cellular_component alt_id: GO:0005716 def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh] xref: Wikipedia:Synaptonemal_complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000796 name: condensin complex namespace: cellular_component alt_id: GO:0005676 alt_id: GO:0008620 def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] subset: goslim_pir synonym: "13S condensin complex" NARROW [] synonym: "SMC complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000797 name: condensin core heterodimer namespace: cellular_component alt_id: GO:0008621 def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] synonym: "8S condensin complex" NARROW [] synonym: "Smc2-Smc4 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000796 ! condensin complex [Term] id: GO:0000798 name: nuclear cohesin complex namespace: cellular_component def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0008278 ! cohesin complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000799 name: nuclear condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] is_a: GO:0000796 ! condensin complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000800 name: lateral element namespace: cellular_component def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000801 name: central element namespace: cellular_component def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000802 name: transverse filament namespace: cellular_component def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome [Term] id: GO:0000804 name: W chromosome namespace: cellular_component def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000805 name: X chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089] xref: Wikipedia:X_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000806 name: Y chromosome namespace: cellular_component def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089] xref: Wikipedia:Y_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000807 name: Z chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000808 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir subset: gosubset_prok synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: Wikipedia:Origin_recognition_complex is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000809 name: cytoplasmic origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] subset: gosubset_prok synonym: "cytoplasmic ORC" EXACT [] synonym: "prokaryotic ORC" RELATED [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000810 name: diacylglycerol diphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [EC:3.1.3.81, GOC:kad, MetaCyc:RXN-11277, PMID:8567632, PMID:9452443] comment: The enzyme entry for EC 3.1.3.81 states that this is a bifunctional enzyme (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/81.html). However, reaction details are only provided for the cumulative enzymatic activity, therefore this term has not been split into two. synonym: "DGPP phosphatase activity" EXACT [] synonym: "DGPP phosphohydrolase activity" EXACT [] synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT [] xref: EC:3.1.3.81 xref: MetaCyc:RXN-11277 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000811 name: GINS complex namespace: cellular_component def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] synonym: "Go, Ichi, Ni and San complex" EXACT [] is_a: GO:0031261 ! DNA replication preinitiation complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000812 name: Swr1 complex namespace: cellular_component def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820] synonym: "SWR-C" EXACT [] is_a: GO:0044454 ! nuclear chromosome part is_a: GO:0097346 ! INO80-type complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000813 name: ESCRT I complex namespace: cellular_component def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000814 name: ESCRT II complex namespace: cellular_component def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000815 name: ESCRT III complex namespace: cellular_component def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000817 name: COMA complex namespace: cellular_component def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000818 name: nuclear MIS12/MIND complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] synonym: "MIND complex" EXACT [] synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] is_a: GO:0000444 ! MIS12/MIND type complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization [Term] id: GO:0000820 name: regulation of glutamine family amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] synonym: "regulation of glutamine family amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0000821 name: regulation of arginine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] synonym: "regulation of arginine metabolism" EXACT [] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process relationship: regulates GO:0006525 ! arginine metabolic process [Term] id: GO:0000822 name: inositol hexakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0000823 name: inositol-1,4,5-trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "inositol trisphosphate 6-kinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: EC:2.7.1.151 xref: KEGG:R05800 xref: MetaCyc:2.7.1.151-RXN is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0000824 name: inositol tetrakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000825 name: inositol tetrakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] xref: MetaCyc:RXN-7184 is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000826 name: inositol pyrophosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326] comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them. synonym: "inositol diphosphate synthase activity" EXACT [] is_obsolete: true consider: GO:0052746 [Term] id: GO:0000827 name: inositol-1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242] synonym: "EC:2.7.4.21" BROAD [] is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000828 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, PMID:16429326] is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000829 name: inositol heptakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326] is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000830 name: inositol hexakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000831 name: inositol hexakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000832 name: inositol hexakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN] synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] xref: EC:2.7.4.21 xref: KEGG:R09087 xref: MetaCyc:2.7.1.152-RXN is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000833 name: inositol heptakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] synonym: "IP7 4-kinase activity" EXACT [] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0000834 name: inositol heptakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0000835 name: ER ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the ER." [GOC:elh] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000836 name: Hrd1p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000837 name: Doa10p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] synonym: "Ssm4p ubiquitin ligase complex" EXACT [] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000838 name: Hrd1p ubiquitin ligase ERAD-M complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000839 name: Hrd1p ubiquitin ligase ERAD-L complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000900 name: translation repressor activity, nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw] is_a: GO:0030371 ! translation repressor activity is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0000901 name: translation repressor activity, non-nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "cellular morphogenesis" EXACT [] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0000903 name: regulation of cell shape during vegetative growth phase namespace: biological_process alt_id: GO:0090061 def: "Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw] synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw] synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED [] is_a: GO:0008360 ! regulation of cell shape relationship: part_of GO:0072690 ! vegetative growth of a single-celled organism [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation namespace: biological_process def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0048468 ! cell development [Term] id: GO:0000905 name: sporocarp development involved in asexual reproduction namespace: biological_process def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] synonym: "conidium development" NARROW [] synonym: "fruiting body formation involved in asexual reproduction" BROAD [] synonym: "haploid fruiting" RELATED [] synonym: "homokaryotic fruiting" RELATED [] synonym: "imperfect stage fruiting body development" NARROW [] synonym: "monokaryotic fruiting" RELATED [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019954 ! asexual reproduction [Term] id: GO:0000906 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:5.4.-.- is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0000907 name: sulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] subset: gosubset_prok synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] synonym: "sulphonate dioxygenase activity" EXACT [] xref: EC:1.14.11.- is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0000908 name: taurine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15912] subset: gosubset_prok synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] xref: EC:1.14.11.17 xref: KEGG:R05320 xref: MetaCyc:RXN0-299 xref: RHEA:15912 is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0000909 name: sporocarp development involved in sexual reproduction namespace: biological_process def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] synonym: "ascus development" NARROW [] synonym: "fruiting body development involved in sexual reproduction" BROAD [] synonym: "fruiting body formation involved in sexual reproduction" BROAD [] synonym: "perfect stage fruiting body development" NARROW [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 def: "The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components, and occurs after division of the nucleus." [GOC:ai, GOC:bf] comment: Note that most eukaryotic gene products involved in canonical cytokinesis during the cell cycle can be annotated to 'cell cycle cytokinesis ; GO:0033205' or its descendants. See also 'cell division ; GO:0051301'. Note that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division. subset: goslim_aspergillus subset: goslim_candida subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_101918 "Mitotic Telophase /Cytokinesis, Mus musculus" xref: Reactome:REACT_108805 "Mitotic Telophase /Cytokinesis, Dictyostelium discoideum" xref: Reactome:REACT_1932 "Mitotic Telophase /Cytokinesis, Homo sapiens" xref: Reactome:REACT_30667 "Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe" xref: Reactome:REACT_32636 "Mitotic Telophase /Cytokinesis, Bos taurus" xref: Reactome:REACT_78494 "Mitotic Telophase /Cytokinesis, Danio rerio" xref: Reactome:REACT_84722 "Mitotic Telophase /Cytokinesis, Gallus gallus" xref: Reactome:REACT_87726 "Mitotic Telophase /Cytokinesis, Xenopus tropicalis" xref: Reactome:REACT_92849 "Mitotic Telophase /Cytokinesis, Taeniopygia guttata" xref: Reactome:REACT_93374 "Mitotic Telophase /Cytokinesis, Canis familiaris" xref: Reactome:REACT_94382 "Mitotic Telophase /Cytokinesis, Drosophila melanogaster" xref: Reactome:REACT_98952 "Mitotic Telophase /Cytokinesis, Rattus norvegicus" xref: Reactome:REACT_99118 "Mitotic Telophase /Cytokinesis, Caenorhabditis elegans" xref: Wikipedia:Cytokinesis is_a: GO:0044763 ! single-organism cellular process relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000911 name: cytokinesis by cell plate formation namespace: biological_process def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000912 name: assembly of actomyosin apparatus involved in cell cycle cytokinesis namespace: biological_process def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:mah] synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000913 name: preprophase band assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah] synonym: "preprophase band formation" RELATED [GOC:mah] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000914 name: phragmoplast assembly namespace: biological_process def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] synonym: "phragmoplast formation" RELATED [goc:dph] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000915 name: cytokinesis, actomyosin contractile ring assembly namespace: biological_process alt_id: GO:0045573 def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] synonym: "constriction ring assembly" NARROW [] synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] synonym: "cytokinesis, actomyosin ring formation" RELATED [] synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis [Term] id: GO:0000916 name: actomyosin contractile ring contraction namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0036213 ! contractile ring contraction relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000917 name: barrier septum assembly namespace: biological_process def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:clt, GOC:mah] synonym: "barrier septum formation" EXACT [GOC:mah] synonym: "formation of barrier septum" EXACT [] synonym: "septation" BROAD [] synonym: "septin assembly and septum biosynthesis" RELATED [] synonym: "septin assembly and septum formation" RELATED [] is_a: GO:0090529 ! cell septum assembly [Term] id: GO:0000918 name: barrier septum site selection namespace: biological_process def: "The process of marking the site where a barrier septum will form." [GOC:clt] synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] synonym: "selection of site for barrier cell septum formation" EXACT [] synonym: "selection of site for barrier septum formation" EXACT [GOC:curators] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] synonym: "septum positioning" EXACT [] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000917 ! barrier septum assembly [Term] id: GO:0000919 name: cell plate assembly namespace: biological_process def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] synonym: "cell plate formation" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000920 name: cytokinetic cell separation namespace: biological_process def: "The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:clt] synonym: "cell separation during cytokinesis" RELATED [GOC:dph, GOC:tb] synonym: "rotokinesis" NARROW [] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0000921 name: septin ring assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] subset: gosubset_prok synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0031106 ! septin ring organization [Term] id: GO:0000922 name: spindle pole namespace: cellular_component alt_id: GO:0030615 def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0000923 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] is_a: GO:0005815 ! microtubule organizing center is_a: GO:0032155 ! cell division site part [Term] id: GO:0000924 name: gamma-tubulin ring complex, centrosomal namespace: cellular_component alt_id: GO:0000925 alt_id: GO:0000926 def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] synonym: "gamma-tubulin large complex, centrosomal" EXACT [] is_a: GO:0008274 ! gamma-tubulin ring complex relationship: part_of GO:0000242 ! pericentriolar material [Term] id: GO:0000927 name: gamma-tubulin small complex, centrosomal namespace: cellular_component def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0008275 ! gamma-tubulin small complex [Term] id: GO:0000928 name: gamma-tubulin small complex, spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075] synonym: "Tub4 complex" EXACT [] is_a: GO:0008275 ! gamma-tubulin small complex relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0000930 name: gamma-tubulin complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044450 ! microtubule organizing center part [Term] id: GO:0000931 name: gamma-tubulin large complex namespace: cellular_component alt_id: GO:0000929 def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0000932 name: cytoplasmic mRNA processing body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "P body" EXACT [] synonym: "P-body" EXACT [] xref: Wikipedia:P_body is_a: GO:0035770 ! ribonucleoprotein granule is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000933 name: adventitious septum namespace: cellular_component def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] is_a: GO:0030428 ! cell septum [Term] id: GO:0000934 name: porous cell septum namespace: cellular_component def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] synonym: "porous septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000935 name: barrier septum namespace: cellular_component def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt] synonym: "complete septum" EXACT [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000936 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000937 name: dolipore septum namespace: cellular_component def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] is_a: GO:0000934 ! porous cell septum [Term] id: GO:0000938 name: GARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] synonym: "Golgi associated retrograde protein complex" EXACT [] synonym: "VFT tethering complex" EXACT [] synonym: "Vps fifty three tethering complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0000939 name: condensed chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] synonym: "inner centromere core complex" RELATED [] synonym: "inner kinetochore of condensed chromosome" EXACT [GOC:curators] synonym: "inner kinetochore plate" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000940 name: condensed chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] synonym: "outer kinetochore of condensed chromosome" EXACT [GOC:curators] synonym: "outer kinetochore plate" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000941 name: condensed nuclear chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [GOC:curators] is_a: GO:0000939 ! condensed chromosome inner kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000942 name: condensed nuclear chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [GOC:curators] is_a: GO:0000940 ! condensed chromosome outer kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000943 name: retrotransposon nucleocapsid namespace: cellular_component def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] synonym: "Virus-like particle" EXACT [] synonym: "VLP" EXACT [] xref: Wikipedia:Virus-like_particle is_a: GO:0044428 ! nuclear part [Term] id: GO:0000944 name: base pairing with rRNA namespace: molecular_function def: "Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA is_a: GO:0019843 ! rRNA binding [Term] id: GO:0000945 name: base pairing with snRNA namespace: molecular_function def: "Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA is_a: GO:0017069 ! snRNA binding [Term] id: GO:0000946 name: base pairing with tRNA namespace: molecular_function def: "Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000049 ! tRNA binding is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0000947 name: amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0000948 name: amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0000949 name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000950 name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] synonym: "branched chain family amino acid catabolic process to alcohol via Ehrlich pathway" EXACT [GOC:krc] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009083 ! branched-chain amino acid catabolic process [Term] id: GO:0000951 name: methionine catabolic process to 3-methylthiopropanol namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000952 name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000953 name: branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] synonym: "branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway" EXACT [GOC:krc] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009083 ! branched-chain amino acid catabolic process [Term] id: GO:0000954 name: methionine catabolic process to 3-methylthiopropanoate namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009087 ! methionine catabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000955 name: amino acid catabolic process via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0000956 name: nuclear-transcribed mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] synonym: "nuclear mRNA breakdown" EXACT [] synonym: "nuclear mRNA catabolism" EXACT [] synonym: "nuclear mRNA degradation" EXACT [] is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000958 name: mitochondrial mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000957 ! mitochondrial RNA catabolic process is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000963 name: mitochondrial RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006396 ! RNA processing is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000964 name: mitochondrial RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 5' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0000966 ! RNA 5'-end processing [Term] id: GO:0000965 name: mitochondrial RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 3' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0000966 name: RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] synonym: "RNA 5' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0000967 name: rRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] synonym: "rRNA 5' end processing" EXACT [] is_a: GO:0034471 ! ncRNA 5'-end processing [Term] id: GO:0000968 name: tRNA exon ligation namespace: biological_process def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc] is_a: GO:0000378 ! RNA exon ligation relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000969 name: tRNA exon ligation utilizing ATP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000970 name: tRNA exon ligation utilizing GTP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000971 name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000972 name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0000973 name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049] is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Term] id: GO:0000974 name: Prp19 complex namespace: cellular_component def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890] synonym: "nineteen complex" NARROW [] synonym: "NTC" RELATED [] synonym: "Prp19/CDC5 complex" NARROW [] is_a: GO:0043234 ! protein complex [Term] id: GO:0000975 name: regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003677 ! DNA binding [Term] id: GO:0000976 name: transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0043565 ! sequence-specific DNA binding is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0000977 name: RNA polymerase II regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding [Term] id: GO:0000978 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH] comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer". synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED [] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding [Term] id: GO:0000979 name: RNA polymerase II core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000980 name: RNA polymerase II distal enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] comment: Note that distal enhancers of the type found in mammalian cells are not known to occur in either Saccharomyces cerevisiae or Schizosaccharomyces pombe. While some S. cerevisiae literature does refer to sequences distal to the initiation site, these distal sites do not seem to function independently of position or orientation as mammalian distal enhancers do and are not considered to be enhancers. is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001158 ! enhancer sequence-specific DNA binding [Term] id: GO:0000981 name: sequence-specific DNA binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0000982 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:txnOH] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0000983 name: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0000984 name: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". subset: gosubset_prok synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001017 ! bacterial-type RNA polymerase regulatory region DNA binding [Term] id: GO:0000985 name: bacterial-type RNA polymerase core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in a bacterial-type RNA polymerase core promoter, the region composed of the transcription start site and binding sites for transcription factors of the basal transcription machinery, in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] subset: gosubset_prok synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000986 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase." [GOC:txnOH] subset: gosubset_prok synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding [Term] id: GO:0000987 name: core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001159 ! core promoter proximal region DNA binding [Term] id: GO:0000988 name: protein binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of protein binding, e.g. transcription factor binding or RNA polymerase binding. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "transcription factor activity" BROAD [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0000989 name: transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000988 ! protein binding transcription factor activity [Term] id: GO:0000990 name: core RNA polymerase binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000988 ! protein binding transcription factor activity [Term] id: GO:0000991 name: core RNA polymerase II binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0000992 name: polymerase III regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0000993 name: RNA polymerase II core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH] is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding is_a: GO:0032403 ! protein complex binding is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0000994 name: RNA polymerase III core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0000995 name: core RNA polymerase III binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:12381659] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0000996 name: core DNA-dependent RNA polymerase binding promoter specificity activity namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA-dependent core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of promoter DNA sequence motifs." [GOC:txnOH] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0000997 name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of the core promoter for the mitochondrial RNA polymerase." [GOC:txnOH] is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000999 name: RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 1 promoters require TFIIIA for promoter recognition, which then recruits TFIIIC. TFIIIC in turn recruits TFIIIB, which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly relationship: part_of GO:0001022 ! transcription initiation from RNA polymerase III type 1 promoter [Term] id: GO:0001000 name: bacterial-type RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH] comment: Should omega be included here? subset: gosubset_prok synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT [] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001001 name: mitochondrial single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182] is_a: GO:0001050 ! single-subunit type RNA polymerase binding [Term] id: GO:0001002 name: RNA polymerase III type 1 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001030 ! RNA polymerase III type 1 promoter DNA binding [Term] id: GO:0001003 name: RNA polymerase III type 2 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001031 ! RNA polymerase III type 2 promoter DNA binding [Term] id: GO:0001004 name: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in an RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter." [GOC:txnOH, PMID:12381659] is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity is_a: GO:0001034 ! sequence-specific DNA binding RNA polymerase III transcription factor activity is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity [Term] id: GO:0001005 name: RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIA. synonym: "TFIIIA activity" RELATED [] synonym: "TFIIIC-type activity" RELATED [] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001006 name: RNA polymerase III type 3 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001032 ! RNA polymerase III type 3 promoter DNA binding [Term] id: GO:0001007 name: RNA polymerase III transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001008 name: RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence motif in a type 2 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 2 Pol III promoters, this requires TFIIIC activity." [GOC:txnOH, PMID:12381659] synonym: "TFIIIC-type activity" RELATED [] synonym: "type 2 RNA polymerase III promoter recognition" EXACT [] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001009 name: transcription from RNA polymerase III type 2 promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 2 RNAP III promoter. Type 2 RNAP III promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001010 name: sequence-specific DNA binding transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH] is_a: GO:0001134 ! transcription factor recruiting transcription factor activity is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001011 name: sequence-specific DNA binding RNA polymerase recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001012 name: RNA polymerase II regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001013 name: RNA polymerase I regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001014 name: snoRNA transcription from a type 2 RNA polymerase III promoter namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH] is_a: GO:0001009 ! transcription from RNA polymerase III type 2 promoter is_a: GO:0009302 ! snoRNA transcription [Term] id: GO:0001015 name: snoRNA transcription from an RNA polymerase II promoter namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0006366 ! transcription from RNA polymerase II promoter is_a: GO:0009302 ! snoRNA transcription [Term] id: GO:0001016 name: RNA polymerase III regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001017 name: bacterial-type RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] subset: gosubset_prok synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001018 name: mitochondrial RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by mitochondrial RNA polymerase. Binding may occur as a high affinity and sequence specific interaction or as a lower affinity interaction observed once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:20056105] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001019 name: plastid RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001020 name: RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly relationship: part_of GO:0001024 ! transcription initiation from RNA polymerase III type 3 promoter [Term] id: GO:0001021 name: RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a type 2 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 2 promoters require TFIIIC for promoter recognition, which then recruits TFIIIB, which in turn which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly relationship: part_of GO:0001023 ! transcription initiation from RNA polymerase III type 2 promoter [Term] id: GO:0001022 name: transcription initiation from RNA polymerase III type 1 promoter namespace: biological_process def: "A transcription initiation process on a type 1 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0042791 ! 5S class rRNA transcription from RNA polymerase III type 1 promoter [Term] id: GO:0001023 name: transcription initiation from RNA polymerase III type 2 promoter namespace: biological_process def: "A transcription initiation process on a type 2 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0001009 ! transcription from RNA polymerase III type 2 promoter [Term] id: GO:0001024 name: transcription initiation from RNA polymerase III type 3 promoter namespace: biological_process def: "A transcription initiation process on a type 3 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0001035 ! transcription from RNA polymerase III type 3 promoter [Term] id: GO:0001025 name: RNA polymerase III transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001026 name: TFIIIB-type transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH] synonym: "RNA polymerase III recruiting transcription factor activity" EXACT [] is_a: GO:0000995 ! core RNA polymerase III binding transcription factor activity is_a: GO:0001007 ! RNA polymerase III transcription factor binding transcription factor activity [Term] id: GO:0001027 name: RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED [] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001028 name: RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED [] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001029 name: RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED [] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001030 name: RNA polymerase III type 1 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding is_a: GO:0080084 ! 5S rDNA binding [Term] id: GO:0001031 name: RNA polymerase III type 2 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001032 name: RNA polymerase III type 3 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001033 name: RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 3 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 3 Pol III promoters, this requires SNAPc activity." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIC. synonym: "SNAPc-type activity" RELATED [] synonym: "type 3 RNA polymerase III promoter recognition" EXACT [] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001034 name: sequence-specific DNA binding RNA polymerase III transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase III. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:12381659] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001035 name: transcription from RNA polymerase III type 3 promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 3 RNAP III promoter. A type 3 RNAP III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] synonym: "U6 snRNA transcription (mammalian)" NARROW [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001036 name: transcription initiation from RNA polymerase III hybrid type promoter namespace: biological_process def: "A transcription initiation process on a hybrid type RNA polymerase III (Pol III) that results in RNA synthesis by Pol III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: part_of GO:0001041 ! transcription from a RNA polymerase III hybrid type promoter [Term] id: GO:0001037 name: RNA polymerase III hybrid type promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001038 name: RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity namespace: molecular_function def: "Once recruited to an RNA polymerase III hybrid type promoter by sequence-specific DNA binding transcription factors, direct DNA binding, or a combination of both, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [Term] id: GO:0001039 name: RNA polymerase III hybrid type promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding [Term] id: GO:0001040 name: RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659] is_a: GO:0001026 ! TFIIIB-type transcription factor activity [Term] id: GO:0001041 name: transcription from a RNA polymerase III hybrid type promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at a hybrid type RNA polymerase III (RNAP III) promoter. A hybrid RNAP III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW [] is_a: GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001042 name: RNA polymerase I core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001043 name: RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a hybrid type RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Hybrid type promoters contain both gene-internal and upstream elements. An example of a hybrid promoter is the U6 snRNA gene." [GOC:txnOH, PMID:12381659] is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly [Term] id: GO:0001044 name: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that controls the transcription of a region of DNA by mitochondrial RNA polymerase." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001018 ! mitochondrial RNA polymerase regulatory region DNA binding [Term] id: GO:0001045 name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase." [GOC:txnOH, PMID:20670382] is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding [Term] id: GO:0001046 name: core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001047 ! core promoter binding [Term] id: GO:0001047 name: core promoter binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001048 name: RNA polymerase IV core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001049 name: RNA polymerase V core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001050 name: single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] synonym: "SP6-type RNA polymerase binding" EXACT [] synonym: "T3-type RNA polymerase binding" EXACT [] synonym: "T3/T7 type RNA polymerase binding" EXACT [] synonym: "T7-type RNA polymerase binding" EXACT [] is_a: GO:0070063 ! RNA polymerase binding [Term] id: GO:0001051 name: plastid single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] is_a: GO:0001050 ! single-subunit type RNA polymerase binding [Term] id: GO:0001052 name: plastid PEP RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995] is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding [Term] id: GO:0001053 name: plastid sigma factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a plastid PEP core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of plastid PEP core promoter DNA sequence motifs." [GOC:txnOH, PMID:20701995] subset: gosubset_prok synonym: "sigma transcription factor" RELATED [] is_a: GO:0016987 ! sigma factor activity [Term] id: GO:0001054 name: RNA polymerase I activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001055 name: RNA polymerase II activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001056 name: RNA polymerase III activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001057 name: RNA polymerase IV activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001058 name: RNA polymerase V activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001059 name: transcription from RNA polymerase IV promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase IV (Pol III), originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459] synonym: "transcription from RNA pol IV promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001060 name: transcription from RNA polymerase V promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase V (Pol III), originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459] synonym: "transcription from RNA pol V promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001061 name: bacterial-type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001062 name: plastid PEP-A RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity [Term] id: GO:0001063 name: plastid PEP-B RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity [Term] id: GO:0001064 name: single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "T3/T7 type RNA polymerase activity" EXACT [] is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0001065 name: mitochondrial single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type mitochondrial RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0001064 ! single subunit type RNA polymerase activity [Term] id: GO:0001066 name: plastid single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001064 ! single subunit type RNA polymerase activity [Term] id: GO:0001067 name: regulatory region nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0001068 name: transcription regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0001069 ! regulatory region RNA binding [Term] id: GO:0001069 name: regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003723 ! RNA binding [Term] id: GO:0001070 name: RNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:8332211] synonym: "transcription factor activity" BROAD [] is_a: GO:0001071 ! nucleic acid binding transcription factor activity [Term] id: GO:0001071 name: nucleic acid binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of nucleic acid binding, e.g. RNA or DNA. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "transcription factor activity" BROAD [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0001072 name: RNA binding transcription antitermination factor activity namespace: molecular_function def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211] subset: gosubset_prok is_a: GO:0001070 ! RNA binding transcription factor activity [Term] id: GO:0001073 name: DNA binding transcription antitermination factor activity namespace: molecular_function def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211] subset: gosubset_prok is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001074 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [Term] id: GO:0001075 name: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT [] is_a: GO:0000983 ! RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [Term] id: GO:0001076 name: RNA polymerase II transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001077 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity is_a: GO:0001228 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Term] id: GO:0001078 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity is_a: GO:0001227 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Term] id: GO:0001079 name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0090293 ! nitrogen catabolite regulation of transcription [Term] id: GO:0001080 name: nitrogen catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090294 ! nitrogen catabolite activation of transcription [Term] id: GO:0001081 name: nitrogen catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090295 ! nitrogen catabolite repression of transcription [Term] id: GO:0001082 name: RNA polymerase I transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001083 name: RNA polymerase II basal transcription factor binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity [Term] id: GO:0001084 name: TFIID-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001085 name: RNA polymerase II transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001086 name: TFIIA-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001087 name: TFIIB-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001088 name: TFIIE-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001089 name: TFIIF-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001090 name: TFIIH-class binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001091 name: RNA polymerase II basal transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] is_a: GO:0001085 ! RNA polymerase II transcription factor binding is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding [Term] id: GO:0001092 name: TFIIA-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001093 name: TFIIB-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001094 name: TFIID-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001095 name: TFIIE-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001096 name: TFIIF-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001097 name: TFIIH-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding [Term] id: GO:0001098 name: basal transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. is_a: GO:0005515 ! protein binding [Term] id: GO:0001099 name: basal RNA polymerase II transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. is_a: GO:0001098 ! basal transcription machinery binding [Term] id: GO:0001100 name: negative regulation of exit from mitosis namespace: biological_process def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] synonym: "down regulation of exit from mitosis" EXACT [] synonym: "down-regulation of exit from mitosis" EXACT [] synonym: "downregulation of exit from mitosis" EXACT [] synonym: "inhibition of exit from mitosis" NARROW [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0010948 ! negative regulation of cell cycle process relationship: negatively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0001101 name: response to acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:rn] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0001102 name: RNA polymerase II activating transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] is_a: GO:0001085 ! RNA polymerase II transcription factor binding is_a: GO:0033613 ! activating transcription factor binding [Term] id: GO:0001103 name: RNA polymerase II repressing transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH] is_a: GO:0001085 ! RNA polymerase II transcription factor binding is_a: GO:0070491 ! repressing transcription factor binding [Term] id: GO:0001104 name: RNA polymerase II transcription cofactor activity namespace: molecular_function alt_id: GO:0016455 def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] subset: gosubset_prok synonym: "RNA polymerase II transcription mediator activity" RELATED [] synonym: "RNA polymerase II transcriptional co-regulator" EXACT [] synonym: "RNA polymerase II transcriptional cofactor activity" EXACT [] synonym: "thyroid receptor-associated protein" RELATED [] synonym: "TRAP protein" RELATED [] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity is_a: GO:0003712 ! transcription cofactor activity [Term] id: GO:0001105 name: RNA polymerase II transcription coactivator activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor. subset: gosubset_prok synonym: "RNA polymerase II transcription co-activator activity" EXACT [] is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity is_a: GO:0001190 ! RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription is_a: GO:0003713 ! transcription coactivator activity [Term] id: GO:0001106 name: RNA polymerase II transcription corepressor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] synonym: "RNA polymerase II transcription co-repressor activity" EXACT [] is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity is_a: GO:0001191 ! RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription is_a: GO:0003714 ! transcription corepressor activity [Term] id: GO:0001108 name: bacterial-type RNA polymerase holo enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH] subset: gosubset_prok synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT [] is_a: GO:0001098 ! basal transcription machinery binding [Term] id: GO:0001109 name: promoter clearance during DNA-dependent transcription namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "promoter escape" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001110 name: promoter clearance from RNA polymerase III promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0001111 name: promoter clearance from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047] synonym: "promoter escape from RNA polymerase II promoter" EXACT [] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0001112 name: DNA-dependent transcriptional open complex formation namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "promoter melting" BROAD [] is_a: GO:0001120 ! protein-DNA complex remodeling relationship: part_of GO:0006352 ! DNA-dependent transcription, initiation [Term] id: GO:0001113 name: transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "RNA polymerase II promoter melting" EXACT [] is_a: GO:0001112 ! DNA-dependent transcriptional open complex formation relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0001114 name: protein-DNA-RNA complex namespace: cellular_component def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH] is_a: GO:0032991 ! macromolecular complex [Term] id: GO:0001115 name: protein-DNA-RNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH] synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization [Term] id: GO:0001116 name: protein-DNA-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034622 ! cellular macromolecular complex assembly [Term] id: GO:0001117 name: protein-DNA-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0032984 ! macromolecular complex disassembly [Term] id: GO:0001118 name: transcription ternary complex disassembly namespace: biological_process def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH] synonym: "transcription protein-DNA-RNA complex disassembly" EXACT [] is_a: GO:0001117 ! protein-DNA-RNA complex disassembly relationship: part_of GO:0006353 ! DNA-dependent transcription, termination [Term] id: GO:0001119 name: protein-DNA-RNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034367 ! macromolecular complex remodeling [Term] id: GO:0001120 name: protein-DNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0034367 ! macromolecular complex remodeling is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0001121 name: transcription from bacterial-type RNA polymerase promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter." [GOC:txnOH] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0001122 name: promoter clearance from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor." [GOC:txnOH, PMID:18280161] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001123 name: transcription initiation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:txnOH, PMID:18280161] is_a: GO:0006352 ! DNA-dependent transcription, initiation relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001124 name: transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] synonym: "RNA elongation from bacterial-type RNA polymerase promoter" EXACT [] is_a: GO:0006354 ! DNA-dependent transcription, elongation relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001125 name: transcription termination from bacterial-type RNA polymerase promoter namespace: biological_process def: "The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed." [GOC:txnOH, PMID:18280161] is_a: GO:0006353 ! DNA-dependent transcription, termination relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter [Term] id: GO:0001126 name: bacterial-type RNA polymerase preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:18280161] synonym: "bacterial-type RNA polymerase transcription PIC biosynthesis" EXACT [] synonym: "bacterial-type RNA polymerase transcription PIC formation" EXACT [] synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" EXACT [] is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001127 name: transcriptional open complex formation at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:18280161] is_a: GO:0001112 ! DNA-dependent transcriptional open complex formation relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001128 name: RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867] comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor. is_a: GO:0001105 ! RNA polymerase II transcription coactivator activity [Term] id: GO:0001129 name: TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] comment: For example, both TFIIA as well as TFIIB interact with TBP bound to DNA to stabilize formation of the preinitiation complex. synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW [] is_a: GO:0001132 ! TBP-class protein binding RNA polymerase II transcription factor activity [Term] id: GO:0001130 name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001131 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001132 name: TBP-class protein binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867] synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW [] synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW [] is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity [Term] id: GO:0001133 name: sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity [Term] id: GO:0001134 name: transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:16858867] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0001135 name: RNA polymerase II transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity is_a: GO:0001134 ! transcription factor recruiting transcription factor activity [Term] id: GO:0001136 name: TFIIE-class transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIE-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001088 ! TFIIE-class binding transcription factor activity is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: GO:0001137 name: TFIIF-class transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIF-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001089 ! TFIIF-class binding transcription factor activity is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: GO:0001138 name: TFIIH-class transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867] is_a: GO:0001090 ! TFIIH-class binding transcription factor activity is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: GO:0001139 name: core RNA polymerase II recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] is_a: GO:0000991 ! core RNA polymerase II binding transcription factor activity [Term] id: GO:0001140 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:20491932, PMID:20629756] is_a: GO:0001131 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity is_a: GO:0001216 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription [Term] id: GO:0001141 name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter." [GOC:txnOH, PMID:20491932, PMID:20629756] is_a: GO:0001131 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity is_a: GO:0001217 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription [Term] id: GO:0001142 name: sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001143 name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence that is part of the core promoter for mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175] is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity [Term] id: GO:0001144 name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175] is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity [Term] id: GO:0001145 name: mitochondrial RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175] is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding [Term] id: GO:0001146 name: mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase in order to promote transcription termination by mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175] is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity [Term] id: GO:0001147 name: transcription termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175] comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation. is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001160 ! transcription termination site DNA binding [Term] id: GO:0001148 name: bacterial-type RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding [Term] id: GO:0001149 name: bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001150 name: bacterial-type RNA polymerase enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:11282468, PMID:20629756] comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer". synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001158 ! enhancer sequence-specific DNA binding [Term] id: GO:0001151 name: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a bacterial-type enhancer region in order to activate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:20629756] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001152 name: RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIA. synonym: "TFIIIA activity" RELATED [] synonym: "type 1 RNA polymerase III promoter recognition" EXACT [] is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity [Term] id: GO:0001153 name: RNA polymerase III transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH] is_a: GO:0001007 ! RNA polymerase III transcription factor binding transcription factor activity is_a: GO:0001134 ! transcription factor recruiting transcription factor activity [Term] id: GO:0001154 name: TFIIIB-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III transcription factor binding [Term] id: GO:0001155 name: TFIIIA-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at type 1 promoters (5S genes) by RNA polymerase III." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III transcription factor binding [Term] id: GO:0001156 name: TFIIIC-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III transcription factor binding [Term] id: GO:0001157 name: RNA polymerase III type 1 promoter TFIIIB recruiting transcription factor activity namespace: molecular_function def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659] comment: This represents TFIIIA. synonym: "TFIIIC-type activity" RELATED [] is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity [Term] id: GO:0001158 name: enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0035326 ! enhancer binding [Term] id: GO:0001159 name: core promoter proximal region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001160 name: transcription termination site DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001161 name: intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0044213 ! intronic transcription regulatory region DNA binding [Term] id: GO:0001162 name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding [Term] id: GO:0001163 name: RNA polymerase I regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] is_a: GO:0001013 ! RNA polymerase I regulatory region DNA binding [Term] id: GO:0001164 name: RNA polymerase I CORE element sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I core element sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase I core promoter sequence-specific DNA binding" EXACT [] is_a: GO:0001046 ! core promoter sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001165 name: RNA polymerase I upstream control element sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED [] is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001166 name: RNA polymerase I enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001158 ! enhancer sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001167 name: sequence-specific DNA binding RNA polymerase I transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001168 name: RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: GO:0001169 name: RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT [] is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: GO:0001170 name: RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: GO:0001171 name: reverse transcription namespace: biological_process def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252] xref: Wikipedia:Reverse_transcription is_a: GO:0006278 ! RNA-dependent DNA replication [Term] id: GO:0001172 name: transcription, RNA-dependent namespace: biological_process def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH] subset: gosubset_prok is_a: GO:0032774 ! RNA biosynthetic process [Term] id: GO:0001173 name: DNA-dependent transcriptional start site selection namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006352 ! DNA-dependent transcription, initiation [Term] id: GO:0001174 name: transcriptional start site selection at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] is_a: GO:0001173 ! DNA-dependent transcriptional start site selection relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0001175 name: transcriptional start site selection at RNA polymerase III promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0001173 ! DNA-dependent transcriptional start site selection relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter [Term] id: GO:0001176 name: transcriptional start site selection at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0001173 ! DNA-dependent transcriptional start site selection relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001177 name: regulation of transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter relationship: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter [Term] id: GO:0001178 name: regulation of transcriptional start site selection at RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter [Term] id: GO:0001179 name: RNA polymerase I transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001180 name: transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript, resulting in the subsequent synthesis of rRNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:txnOH] is_a: GO:0006361 ! transcription initiation from RNA polymerase I promoter relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Term] id: GO:0001181 name: core RNA polymerase I binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase I (RNAP I) complex, typically composed of fourteen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity [Term] id: GO:0001182 name: promoter clearance from RNA polymerase I promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0001183 name: transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:txnOH] is_a: GO:0006362 ! transcription elongation from RNA polymerase I promoter relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Term] id: GO:0001184 name: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] is_a: GO:0001182 ! promoter clearance from RNA polymerase I promoter relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Term] id: GO:0001185 name: termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript namespace: biological_process def: "The process in which the synthesis of an rRNA molecule from a promoter for the nuclear large ribosomal RNA (rRNA) transcript by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:txnOH] is_a: GO:0006363 ! termination of RNA polymerase I transcription relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Term] id: GO:0001186 name: RNA polymerase I transcription factor recruiting transcription factor activity namespace: molecular_function def: "The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] is_a: GO:0001082 ! RNA polymerase I transcription factor binding transcription factor activity is_a: GO:0001134 ! transcription factor recruiting transcription factor activity [Term] id: GO:0001187 name: RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] is_a: GO:0001169 ! RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity is_a: GO:0001186 ! RNA polymerase I transcription factor recruiting transcription factor activity [Term] id: GO:0001188 name: RNA polymerase I transcriptional preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly relationship: part_of GO:0006361 ! transcription initiation from RNA polymerase I promoter [Term] id: GO:0001189 name: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on CORE promoter element DNA of the nuclear large ribosomal RNA (rRNA) transcript to form a transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the large rRNA promoter, resulting in the subsequent synthesis of the large rRNA transcript." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] is_a: GO:0001188 ! RNA polymerase I transcriptional preinitiation complex assembly relationship: part_of GO:0001180 ! transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript [Term] id: GO:0001190 name: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity [Term] id: GO:0001191 name: RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836] is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity [Term] id: GO:0001192 name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006354 ! DNA-dependent transcription, elongation [Term] id: GO:0001193 name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-dependent transcription elongation relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0001194 name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter." [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-dependent transcription elongation relationship: part_of GO:0001124 ! transcription elongation from bacterial-type RNA polymerase promoter [Term] id: GO:0001195 name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-dependent transcription elongation relationship: part_of GO:0006385 ! transcription elongation from RNA polymerase III promoter [Term] id: GO:0001196 name: regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-dependent [Term] id: GO:0001197 name: positive regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter is_a: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-dependent [Term] id: GO:0001198 name: negative regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW [] is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter is_a: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-dependent [Term] id: GO:0001199 name: metal ion regulated sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity [Term] id: GO:0001200 name: metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity [Term] id: GO:0001201 name: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor that binds the core promoter proximal region in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity is_a: GO:0001200 ! metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001202 name: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001203 name: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), in such a way that zinc ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:22084422] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001204 name: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity [Term] id: GO:0001205 name: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" EXACT [] is_a: GO:0001228 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription is_a: GO:0003705 ! RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Term] id: GO:0001206 name: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" EXACT [] is_a: GO:0001227 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription is_a: GO:0003705 ! RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Term] id: GO:0001207 name: histone displacement namespace: biological_process def: "The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0001208 name: histone H2A-H2B dimer displacement namespace: biological_process def: "The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0001207 ! histone displacement [Term] id: GO:0001209 name: metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity [Term] id: GO:0001210 name: metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity [Term] id: GO:0001211 name: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001202 ! copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity is_a: GO:0001213 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription [Term] id: GO:0001212 name: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001203 ! zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity is_a: GO:0001213 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription [Term] id: GO:0001213 name: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001077 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001214 name: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH, PMID:22084422, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001078 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001215 name: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001204 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity is_a: GO:0001209 ! metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Term] id: GO:0001216 name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:krc] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001217 name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:krc] is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity [Term] id: GO:0001218 name: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688] comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor. is_a: GO:0001204 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity is_a: GO:0001210 ! metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Term] id: GO:0001219 name: copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), in such a way that copper ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase." [GOC:krc, PMID:12829264, PMID:12829265, PMID:19928961] synonym: "copper ion sensor" RELATED [] is_a: GO:0001218 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription [Term] id: GO:0001220 name: cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with cadmium (Cd) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd), in such a way that cadmium (Cd) ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase." [GOC:krc, PMID:12829264, PMID:12829265, PMID:19456862] synonym: "cadmium ion sensor" RELATED [] is_a: GO:0001218 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription [Term] id: GO:0001221 name: transcription cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001222 name: transcription corepressor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding [Term] id: GO:0001223 name: transcription coactivator binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding [Term] id: GO:0001224 name: RNA polymerase II transcription cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding [Term] id: GO:0001225 name: RNA polymerase II transcription coactivator binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001223 ! transcription coactivator binding is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding [Term] id: GO:0001226 name: RNA polymerase II transcription corepressor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001222 ! transcription corepressor binding is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding [Term] id: GO:0001227 name: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001228 name: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:krc] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0001300 name: chronological cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] synonym: "chronological cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001301 name: progressive alteration of chromatin involved in cell aging namespace: biological_process def: "The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938] synonym: "age-dependent accumulation of genetic damage" RELATED [] synonym: "progressive alteration of chromatin during cell ageing" EXACT [] synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0016568 ! chromatin modification relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0001302 name: replicative cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] synonym: "replicative cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001303 name: nucleolar fragmentation involved in replicative aging namespace: biological_process def: "A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] synonym: "nucleolar fragmentation during replicative ageing" RELATED [] synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007576 ! nucleolar fragmentation relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001304 name: progressive alteration of chromatin involved in replicative cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001305 name: progressive alteration of chromatin involved in chronological cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED [] synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001306 name: age-dependent response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] is_a: GO:0006979 ! response to oxidative stress relationship: part_of GO:0007571 ! age-dependent general metabolic decline [Term] id: GO:0001307 name: extrachromosomal circular DNA accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging [Term] id: GO:0001308 name: negative regulation of chromatin silencing involved in replicative cell aging namespace: biological_process def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] synonym: "loss of chromatin silencing during replicative cell ageing" RELATED [] synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT [] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0031936 ! negative regulation of chromatin silencing [Term] id: GO:0001309 name: age-dependent telomere shortening namespace: biological_process def: "Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0010834 ! telomere maintenance via telomere shortening [Term] id: GO:0001310 name: extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [] is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001311 name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED [] is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging is_a: GO:0045458 ! recombination within rDNA repeats relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001312 name: replication of extrachromosomal rDNA circles involved in replicative cell aging namespace: biological_process def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED [] synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED [] is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001313 name: formation of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT [] synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001325 ! formation of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001314 name: replication of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001326 ! replication of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001315 name: age-dependent response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] subset: gosubset_prok synonym: "age-dependent response to active oxygen species" EXACT [] synonym: "age-dependent response to AOS" EXACT [] synonym: "age-dependent response to reactive oxidative species" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] synonym: "age-dependent response to ROI" EXACT [] synonym: "age-dependent response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001306 ! age-dependent response to oxidative stress [Term] id: GO:0001316 name: age-dependent response to reactive oxygen species involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] subset: Cross_product_review synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED [] synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during replicative cell aging" RELATED [] synonym: "age-dependent response to ROS during replicative cell aging" RELATED [] is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001317 name: accumulation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] subset: Cross_product_review synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging [Term] id: GO:0001318 name: formation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001319 name: inheritance of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0008105 ! asymmetric protein localization relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001320 name: age-dependent response to reactive oxygen species involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED [] synonym: "age-dependent response to AOS during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during chronological cell aging" RELATED [] synonym: "age-dependent response to ROS during chronological cell aging" RELATED [] is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001321 name: age-dependent general metabolic decline involved in replicative cell aging namespace: biological_process def: "A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED [] synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001322 name: age-dependent response to oxidative stress involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0034599 ! cellular response to oxidative stress relationship: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging [Term] id: GO:0001323 name: age-dependent general metabolic decline involved in chronological cell aging namespace: biological_process def: "A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED [] synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001324 name: age-dependent response to oxidative stress involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0034599 ! cellular response to oxidative stress relationship: part_of GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging [Term] id: GO:0001325 name: formation of extrachromosomal circular DNA namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] subset: gosubset_prok synonym: "assembly of extrachromosomal circular DNA" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0001326 name: replication of extrachromosomal circular DNA namespace: biological_process def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] subset: gosubset_prok is_a: GO:0006260 ! DNA replication [Term] id: GO:0001400 name: mating projection base namespace: cellular_component def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] synonym: "base of shmoo tip" NARROW [] synonym: "conjugation tube base" NARROW [] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0001401 name: mitochondrial sorting and assembly machinery complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. synonym: "SAM complex" EXACT [] synonym: "TOB complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0001402 name: signal transduction involved in filamentous growth namespace: biological_process def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0030447 ! filamentous growth [Term] id: GO:0001403 name: invasive growth in response to glucose limitation namespace: biological_process def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395] comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. subset: goslim_yeast synonym: "colony morphology" RELATED [] is_a: GO:0036267 ! invasive filamentous growth [Term] id: GO:0001404 name: invasive growth namespace: biological_process def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] comment: This term was made obsolete because more appropriate terms were created. synonym: "tissue invasion" EXACT [] is_obsolete: true consider: GO:0044409 [Term] id: GO:0001405 name: presequence translocase-associated import motor namespace: cellular_component def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855] synonym: "mitochondrial import motor" EXACT [] synonym: "PAM complex" EXACT [] synonym: "pre-sequence translocase-associated import motor" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex [Term] id: GO:0001406 name: glycerophosphodiester transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity [Term] id: GO:0001407 name: glycerophosphodiester transport namespace: biological_process def: "The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0001408 name: guanine nucleotide transport namespace: biological_process def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc] is_a: GO:0015858 ! nucleoside transport is_a: GO:0015868 ! purine ribonucleotide transport [Term] id: GO:0001409 name: guanine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0001410 name: chlamydospore formation namespace: biological_process alt_id: GO:0055027 def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] synonym: "chlamydospore development" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0001411 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida is_a: GO:0030427 ! site of polarized growth [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development [Term] id: GO:0001502 name: cartilage condensation namespace: biological_process def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0001504 name: neurotransmitter uptake namespace: biological_process def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft." [ISBN:0123668387] synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "neurotransmitter import into glial cell" NARROW [] synonym: "neurotransmitter import into neuron" NARROW [] synonym: "neurotransmitter recycling" BROAD [] synonym: "neurotransmitter reuptake" EXACT [] xref: Reactome:REACT_106095 "Neurotransmitter uptake and Metabolism In Glial Cells, Gallus gallus" xref: Reactome:REACT_106673 "Neurotransmitter uptake and Metabolism In Glial Cells, Bos taurus" xref: Reactome:REACT_107830 "Neurotransmitter uptake and Metabolism In Glial Cells, Arabidopsis thaliana" xref: Reactome:REACT_114027 "Neurotransmitter uptake and Metabolism In Glial Cells, Staphylococcus aureus N315" xref: Reactome:REACT_13594 "Neurotransmitter uptake and Metabolism In Glial Cells, Homo sapiens" xref: Reactome:REACT_29399 "Neurotransmitter uptake and Metabolism In Glial Cells, Drosophila melanogaster" xref: Reactome:REACT_30311 "Neurotransmitter uptake and Metabolism In Glial Cells, Rattus norvegicus" xref: Reactome:REACT_82534 "Neurotransmitter uptake and Metabolism In Glial Cells, Caenorhabditis elegans" xref: Reactome:REACT_88126 "Neurotransmitter uptake and Metabolism In Glial Cells, Escherichia coli" xref: Reactome:REACT_89424 "Neurotransmitter uptake and Metabolism In Glial Cells, Sus scrofa" xref: Reactome:REACT_92363 "Neurotransmitter uptake and Metabolism In Glial Cells, Canis familiaris" xref: Reactome:REACT_93291 "Neurotransmitter uptake and Metabolism In Glial Cells, Taeniopygia guttata" xref: Reactome:REACT_94616 "Neurotransmitter uptake and Metabolism In Glial Cells, Schizosaccharomyces pombe" xref: Reactome:REACT_97761 "Neurotransmitter uptake and Metabolism In Glial Cells, Saccharomyces cerevisiae" xref: Reactome:REACT_98224 "Neurotransmitter uptake and Metabolism In Glial Cells, Oryza sativa" xref: Reactome:REACT_98482 "Neurotransmitter uptake and Metabolism In Glial Cells, Xenopus tropicalis" xref: Reactome:REACT_98978 "Neurotransmitter uptake and Metabolism In Glial Cells, Danio rerio" xref: Reactome:REACT_99735 "Neurotransmitter uptake and Metabolism In Glial Cells, Mus musculus" is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport [Term] id: GO:0001505 name: regulation of neurotransmitter levels namespace: biological_process def: "Any process that modulates levels of neurotransmitter." [GOC:jl] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0001506 name: neurotransmitter biosynthetic process and storage namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] comment: This term was made obsolete because it is an amalgamation of its two children. synonym: "neurotransmitter anabolism and storage" EXACT [] synonym: "neurotransmitter formation and storage" EXACT [] synonym: "neurotransmitter synthesis and storage" EXACT [] is_obsolete: true consider: GO:0042136 consider: GO:0042137 [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0001508 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001509 name: legumain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] comment: This term was made obsolete because it represents a gene product. synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "citvac" RELATED [EC:3.4.22.34] synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] xref: EC:3.4.22.34 xref: MetaCyc:3.4.22.34-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0001510 name: RNA methylation namespace: biological_process def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] subset: gosubset_prok is_a: GO:0009451 ! RNA modification is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0001511 name: fibrillin namespace: molecular_function def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0001527 consider: GO:0005509 [Term] id: GO:0001512 name: dihydronicotinamide riboside quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] synonym: "NQO2" RELATED [EC:1.10.99.2] synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] synonym: "QR2 activity" RELATED [EC:1.10.99.2] synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: MetaCyc:1.10.99.2-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0001514 name: selenocysteine incorporation namespace: biological_process def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] subset: gosubset_prok xref: RESID:AA0022 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732] is_a: GO:0005102 ! receptor binding [Term] id: GO:0001516 name: prostaglandin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] subset: gosubset_prok synonym: "prostaglandin anabolism" EXACT [] synonym: "prostaglandin biosynthesis" EXACT [] synonym: "prostaglandin formation" EXACT [] synonym: "prostaglandin synthesis" EXACT [] is_a: GO:0006693 ! prostaglandin metabolic process is_a: GO:0046457 ! prostanoid biosynthetic process [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001518 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: NIF_Subcellular:sao785001660 is_a: GO:0034706 ! sodium channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0001519 name: peptide amidation namespace: biological_process def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] subset: gosubset_prok is_a: GO:0031179 ! peptide modification [Term] id: GO:0001520 name: outer dense fiber namespace: cellular_component def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820] synonym: "outer dense fibre" EXACT [] is_a: GO:0044447 ! axoneme part [Term] id: GO:0001522 name: pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] subset: gosubset_prok synonym: "pseudouridylation" EXACT [] xref: Wikipedia:Pseudouridine xref: Wikipedia:Pseudouridylation is_a: GO:0009451 ! RNA modification [Term] id: GO:0001523 name: retinoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732] subset: gosubset_prok synonym: "retinoid metabolism" EXACT [] xref: Reactome:REACT_24968 "Vitamin A uptake in enterocytes, Homo sapiens" is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0001524 name: globin namespace: molecular_function def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001526 name: proteoglycan sulfate transfer namespace: biological_process def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] comment: This term was made obsolete because it represents a group of molecular functions. synonym: "proteoglycan sulphate transfer" EXACT [] is_obsolete: true consider: GO:0006029 consider: GO:0006790 consider: GO:0050698 [Term] id: GO:0001527 name: microfibril namespace: cellular_component def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235] synonym: "extended fibrils" EXACT [] synonym: "fibrillin" RELATED [] is_a: GO:0043205 ! fibril [Term] id: GO:0001528 name: elastin namespace: molecular_function def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001529 name: elastin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001530 name: lipopolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] synonym: "endotoxin binding" BROAD [] synonym: "LPS binding" EXACT [] is_a: GO:0008289 ! lipid binding [Term] id: GO:0001531 name: interleukin-21 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai] synonym: "IL-21" NARROW [] synonym: "interleukin-21 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0001532 name: interleukin-21 receptor activity namespace: molecular_function def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-21 receptor activity" EXACT [GOC:mah] synonym: "IL-21R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0001533 name: cornified envelope namespace: cellular_component def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0001534 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] subset: goslim_pir xref: Wikipedia:Radial_spoke is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0001535 name: radial spokehead namespace: cellular_component def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001536 name: radial spoke stalk namespace: cellular_component def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001537 name: N-acetylgalactosamine 4-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001539 name: ciliary or flagellar motility namespace: biological_process def: "Cell motility due to movement of cilia or flagella." [GOC:hjd] subset: gosubset_prok synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0001540 name: beta-amyloid binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd] is_a: GO:0042277 ! peptide binding [Term] id: GO:0001541 name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators] synonym: "follicular phase" RELATED [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001542 name: ovulation from ovarian follicle namespace: biological_process def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030728 ! ovulation relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001543 name: ovarian follicle rupture namespace: biological_process def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001542 ! ovulation from ovarian follicle [Term] id: GO:0001544 name: initiation of primordial ovarian follicle growth namespace: biological_process def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001545 name: primary ovarian follicle growth namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001546 name: preantral ovarian follicle growth namespace: biological_process def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development relationship: part_of GO:0048162 ! multi-layer follicle stage [Term] id: GO:0001547 name: antral ovarian follicle growth namespace: biological_process def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001548 name: follicular fluid formation in ovarian follicle antrum namespace: biological_process def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu] synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth [Term] id: GO:0001549 name: cumulus cell differentiation namespace: biological_process def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu] synonym: "ovarian cumulus cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001550 name: ovarian cumulus expansion namespace: biological_process def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu] synonym: "ovarian cumulus growth" RELATED [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001551 name: ovarian follicle endowment namespace: biological_process def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001552 name: ovarian follicle atresia namespace: biological_process def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, http://ovary.stanford.edu, PMID:18638134] is_a: GO:0048610 ! cellular process involved in reproduction relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001553 name: luteinization namespace: biological_process def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu] synonym: "luteal phase" RELATED [] xref: Wikipedia:Luteal_phase xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001554 name: luteolysis namespace: biological_process def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [http://ovary.stanford.edu, PMID:10617764] xref: Wikipedia:Luteolysis is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001557 name: metabolic process resulting in cell growth namespace: biological_process def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms. is_obsolete: true replaced_by: GO:0008152 replaced_by: GO:0016049 [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] subset: gosubset_prok xref: Reactome:REACT_6201 "DTOR is positively regulated by DRheb-GTP, Drosophila melanogaster" is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001559 name: regulation of cell growth by detection of nuclear:cytoplasmic ratio namespace: biological_process def: "Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio is_a: GO:0061387 ! regulation of extent of cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth relationship: part_of GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0001561 name: fatty acid alpha-oxidation namespace: biological_process def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html] subset: gosubset_prok xref: MetaCyc:PWY-2501 xref: Reactome:REACT_103076 "Alpha-oxidation of phytanate, Dictyostelium discoideum" xref: Reactome:REACT_106518 "Alpha-oxidation of phytanate, Drosophila melanogaster" xref: Reactome:REACT_106956 "Alpha-oxidation of phytanate, Mus musculus" xref: Reactome:REACT_107335 "Alpha-oxidation of phytanate, Taeniopygia guttata" xref: Reactome:REACT_109097 "Alpha-oxidation of phytanate, Saccharomyces cerevisiae" xref: Reactome:REACT_17003 "Alpha-oxidation of phytanate, Homo sapiens" xref: Reactome:REACT_29885 "Alpha-oxidation of phytanate, Oryza sativa" xref: Reactome:REACT_47735 "Alpha-oxidation of phytanate, Gallus gallus" xref: Reactome:REACT_78088 "Alpha-oxidation of phytanate, Bos taurus" xref: Reactome:REACT_81097 "Alpha-oxidation of phytanate, Xenopus tropicalis" xref: Reactome:REACT_83317 "Alpha-oxidation of phytanate, Caenorhabditis elegans" xref: Reactome:REACT_87622 "Alpha-oxidation of phytanate, Sus scrofa" xref: Reactome:REACT_87835 "Alpha-oxidation of phytanate, Arabidopsis thaliana" xref: Reactome:REACT_90750 "Alpha-oxidation of phytanate, Canis familiaris" xref: Reactome:REACT_92361 "Alpha-oxidation of phytanate, Mycobacterium tuberculosis" xref: Reactome:REACT_94726 "Alpha-oxidation of phytanate, Escherichia coli" xref: Reactome:REACT_94872 "Alpha-oxidation of phytanate, Rattus norvegicus" xref: Reactome:REACT_96409 "Alpha-oxidation of phytanate, Danio rerio" xref: Reactome:REACT_98637 "Alpha-oxidation of phytanate, Schizosaccharomyces pombe" is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0001562 name: response to protozoan namespace: biological_process alt_id: GO:0042833 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] synonym: "resistance to pathogenic protozoa" RELATED [] synonym: "response to protozoa" EXACT [] synonym: "response to protozoon" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0001563 name: detection of protozoan namespace: biological_process def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] synonym: "detection of protozoa" EXACT [] synonym: "detection of protozoon" EXACT [] synonym: "perception of protozoa" RELATED [] is_a: GO:0001562 ! response to protozoan is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0001564 name: resistance to pathogenic protozoa namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0001562 [Term] id: GO:0001565 name: phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0001566 name: non-kinase phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570] is_a: GO:0001565 ! phorbol ester receptor activity [Term] id: GO:0001567 name: cholesterol 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21107] synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] xref: EC:1.14.99.38 xref: KEGG:R07218 xref: MetaCyc:1.14.99.38-RXN xref: RHEA:21107 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001569 name: patterning of blood vessels namespace: biological_process def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "branching involved in blood vessel morphogenesis" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process is_a: GO:0048754 ! branching morphogenesis of an epithelial tube relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001571 name: non-tyrosine kinase fibroblast growth factor receptor activity namespace: molecular_function def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238] synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] synonym: "non-tyrosine kinase FGFR activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0001572 name: lactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501] subset: gosubset_prok synonym: "lactosylceramide anabolism" EXACT [] synonym: "lactosylceramide biosynthesis" EXACT [] synonym: "lactosylceramide formation" EXACT [] synonym: "lactosylceramide synthesis" EXACT [] is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046478 ! lactosylceramide metabolic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0001573 name: ganglioside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] subset: gosubset_prok synonym: "ganglioside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001574 name: ganglioside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] subset: gosubset_prok synonym: "ganglioside anabolism" EXACT [] synonym: "ganglioside biosynthesis" EXACT [] synonym: "ganglioside formation" EXACT [] synonym: "ganglioside synthesis" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0001575 name: globoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732] subset: gosubset_prok synonym: "globoside metabolism" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001576 name: globoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732] subset: gosubset_prok synonym: "globoside anabolism" EXACT [] synonym: "globoside biosynthesis" EXACT [] synonym: "globoside formation" EXACT [] synonym: "globoside synthesis" EXACT [] is_a: GO:0001575 ! globoside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001577 name: galectin namespace: molecular_function def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] comment: This term was made obsolete because it refers to a class of gene products. synonym: "S-type lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0016936 [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001579 name: medium-chain fatty acid transport namespace: biological_process def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0001580 name: detection of chemical stimulus involved in sensory perception of bitter taste namespace: biological_process def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "bitter taste detection" EXACT [] synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of bitter taste" EXACT [] synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] synonym: "sensory transduction of bitter taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050913 ! sensory perception of bitter taste [Term] id: GO:0001581 name: detection of chemical stimulus involved in sensory perception of sour taste namespace: biological_process def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory detection of sour taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory transduction of sour taste" EXACT [] synonym: "sour taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050915 ! sensory perception of sour taste [Term] id: GO:0001582 name: detection of chemical stimulus involved in sensory perception of sweet taste namespace: biological_process def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory detection of sweet taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory transduction of sweet taste" EXACT [] synonym: "sweet taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050916 ! sensory perception of sweet taste [Term] id: GO:0001583 name: detection of chemical stimulus involved in sensory perception of salty taste namespace: biological_process def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] synonym: "salty taste detection" EXACT [] synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory detection of salty taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory transduction of salty taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050914 ! sensory perception of salty taste [Term] id: GO:0001584 name: rhodopsin-like receptor activity namespace: molecular_function alt_id: GO:0001620 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] comment: This term was made obsolete because it represents a gene product and is named based on protein features. subset: gosubset_prok synonym: "Class A G protein coupled receptor" EXACT [] synonym: "Class A G-protein coupled receptor" EXACT [] synonym: "Class A GPCR" EXACT [] synonym: "class A orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001586 name: Gi/o-coupled serotonin receptor activity namespace: molecular_function def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247] synonym: "5-HT1 receptor activity" EXACT [GOC:bf] synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf] is_a: GO:0004993 ! serotonin receptor activity [Term] id: GO:0001587 name: Gq/11-coupled serotonin receptor activity namespace: molecular_function def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043] synonym: "5-HT2 receptor activity" BROAD [GOC:bf] synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf] is_a: GO:0004993 ! serotonin receptor activity [Term] id: GO:0001588 name: dopamine neurotransmitter receptor activity, coupled via Gs namespace: molecular_function alt_id: GO:0001589 alt_id: GO:0001590 def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260] synonym: "dopamine D1 receptor activity" NARROW [GOC:bf] synonym: "dopamine D5 receptor activity" NARROW [GOC:bf] is_a: GO:0004952 ! dopamine neurotransmitter receptor activity [Term] id: GO:0001591 name: dopamine neurotransmitter receptor activity, coupled via Gi/Go namespace: molecular_function alt_id: GO:0001592 alt_id: GO:0001593 alt_id: GO:0001670 def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258] synonym: "dopamine D2 receptor activity" NARROW [GOC:bf] synonym: "dopamine D3 receptor activity" NARROW [GOC:bf] synonym: "dopamine D4 receptor activity" NARROW [GOC:bf] is_a: GO:0004952 ! dopamine neurotransmitter receptor activity [Term] id: GO:0001594 name: trace-amine receptor activity namespace: molecular_function def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0001595 name: angiotensin receptor activity namespace: molecular_function def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G-protein coupled peptide receptor activity [Term] id: GO:0001596 name: angiotensin type I receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869] is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0001597 name: apelin-like receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because the function it represents does not exist. synonym: "APJ-like receptor" EXACT [] is_obsolete: true consider: GO:0031704 [Term] id: GO:0001598 name: chemokine receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001601 name: peptide YY receptor activity namespace: molecular_function def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001602 name: pancreatic polypeptide receptor activity namespace: molecular_function def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001603 name: vasopressin-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] is_obsolete: true [Term] id: GO:0001604 name: urotensin II receptor activity namespace: molecular_function def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493] is_a: GO:0008528 ! G-protein coupled peptide receptor activity [Term] id: GO:0001605 name: adrenomedullin receptor activity namespace: molecular_function def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] synonym: "G10D receptor" NARROW [] is_a: GO:0008528 ! G-protein coupled peptide receptor activity [Term] id: GO:0001606 name: GPR37/endothelin B-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001607 name: neuromedin U receptor activity namespace: molecular_function def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] synonym: "NMUR activity" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0001608 name: G-protein coupled nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294] synonym: "G protein coupled nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled nucleotide receptor activity" EXACT [] synonym: "nucleotide receptor activity, G protein coupled" EXACT [] synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001609 name: G-protein coupled adenosine receptor activity namespace: molecular_function alt_id: GO:0001610 alt_id: GO:0001611 alt_id: GO:0001612 alt_id: GO:0001613 alt_id: GO:0008501 def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289] synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "adenosine nucleotide receptor" BROAD [] synonym: "adenosine receptor activity, G protein coupled" EXACT [] synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] synonym: "G protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled adenosine receptor activity" EXACT [] synonym: "P1 receptor" EXACT [PMID:9755289] xref: Reactome:REACT_105855 "TRKA activation by adenosine A2a receptor, Bos taurus" xref: Reactome:REACT_110350 "TRKA activation by adenosine A2a receptor, Canis familiaris" xref: Reactome:REACT_11079 "TrkA activation by adenosine A2a receptor, Rattus norvegicus" xref: Reactome:REACT_29695 "TRKA activation by adenosine A2a receptor, Sus scrofa" xref: Reactome:REACT_36513 "TRKA activation by adenosine A2a receptor, Gallus gallus" xref: Reactome:REACT_79823 "TRKA activation by adenosine A2a receptor, Danio rerio" xref: Reactome:REACT_89799 "TRKA activation by adenosine A2a receptor, Taeniopygia guttata" xref: Reactome:REACT_97530 "TRKA activation by adenosine A2a receptor, Xenopus tropicalis" xref: Reactome:REACT_9980 "TRKA activation by adenosine A2a receptor, Homo sapiens" xref: Reactome:REACT_99869 "TRKA activation by adenosine A2a receptor, Mus musculus" is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0035586 ! purinergic receptor activity [Term] id: GO:0001614 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "P2 receptor" RELATED [PMID:9755289] is_a: GO:0016502 ! nucleotide receptor activity is_a: GO:0035586 ! purinergic receptor activity [Term] id: GO:0001615 name: thyrotropin releasing hormone and secretagogue-like receptors activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001616 name: growth hormone secretagogue receptor activity namespace: molecular_function def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853] synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001617 name: growth hormone secretagogue-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001618 name: viral receptor activity namespace: molecular_function def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403] is_a: GO:0004872 ! receptor activity [Term] id: GO:0001619 name: lysosphingolipid and lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] is_obsolete: true consider: GO:0038036 consider: GO:0070915 [Term] id: GO:0001621 name: ADP receptor activity namespace: molecular_function def: "Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:11196645] synonym: "K101 receptor" NARROW [] synonym: "platelet ADP receptor activity" NARROW [GOC:mah] is_a: GO:0045028 ! G-protein coupled purinergic nucleotide receptor activity [Term] id: GO:0001626 name: nociceptin receptor activity namespace: molecular_function def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432] synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf] synonym: "OFQ receptor activity" EXACT [PR:000012940] synonym: "ORPH receptor" EXACT [] synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf] synonym: "X-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0001627 name: leucine-rich G-protein receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] synonym: "LGR-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001628 name: gastropyloric receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the gastropyloric receptor is a type of neuron. synonym: "GPR receptor" EXACT [] is_obsolete: true [Term] id: GO:0001629 name: G-protein receptor 45-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "G protein receptor 45-like receptor activity" EXACT [] synonym: "GPR45-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001630 name: GP40-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001631 name: cysteinyl leukotriene receptor activity namespace: molecular_function def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] synonym: "CysLT receptor" EXACT [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001632 name: leukotriene B4 receptor activity namespace: molecular_function def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732] synonym: "BLT receptor" NARROW [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001633 name: secretin-like receptor activity namespace: molecular_function alt_id: GO:0001638 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class B G protein coupled receptor" EXACT [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "class B GPCR" EXACT [] synonym: "class B orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001634 name: pituitary adenylate cyclase-activating polypeptide receptor activity namespace: molecular_function alt_id: GO:0016522 def: "A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb] synonym: "PACAP receptor" EXACT [] synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED [] synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED [] synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] xref: Reactome:REACT_10128 "TRKA activation by PACAP type 1 receptor, Homo sapiens" xref: Reactome:REACT_101685 "TRKA activation by PACAP type 1 receptor, Canis familiaris" xref: Reactome:REACT_109490 "TRKA activation by PACAP type 1 receptor, Taeniopygia guttata" xref: Reactome:REACT_11114 "TrkA activation by PACAP type 1 receptor, Rattus norvegicus" xref: Reactome:REACT_34105 "TRKA activation by PACAP type 1 receptor, Mus musculus" xref: Reactome:REACT_86120 "TRKA activation by PACAP type 1 receptor, Xenopus tropicalis" xref: Reactome:REACT_87714 "TRKA activation by PACAP type 1 receptor, Bos taurus" xref: Reactome:REACT_91558 "TRKA activation by PACAP type 1 receptor, Danio rerio" xref: Reactome:REACT_92997 "TRKA activation by PACAP type 1 receptor, Gallus gallus" xref: Reactome:REACT_96326 "TRKA activation by PACAP type 1 receptor, Sus scrofa" is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001635 name: calcitonin gene-related polypeptide receptor activity namespace: molecular_function def: "Combining with a calcitonin gene-related polypeptide to initiate a change in cell activity." [GOC:mah, PMID:12037140] synonym: "CGRP receptor" EXACT [] xref: Wikipedia:CALCRL is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001636 name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001637 name: G-protein coupled chemoattractant receptor activity namespace: molecular_function def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah] synonym: "G protein chemoattractant receptor activity" EXACT [] synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf] is_a: GO:0008528 ! G-protein coupled peptide receptor activity [Term] id: GO:0001639 name: PLC activating G-protein coupled glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] synonym: "Group I metabotropic glutamate receptor" RELATED [] synonym: "group I metabotropic glutamate receptor activity" RELATED [] synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf] is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0001640 name: adenylate cyclase inhibiting G-protein coupled glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph] synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf] synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0001641 name: group II metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] is_a: GO:0001640 ! adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [Term] id: GO:0001642 name: group III metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] is_a: GO:0001640 ! adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [Term] id: GO:0001646 name: cAMP receptor activity namespace: molecular_function alt_id: GO:0001644 def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg] synonym: "3',5' cAMP receptor activity" EXACT [] synonym: "3',5'-cAMP receptor activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] synonym: "class E G protein coupled receptor" BROAD [] synonym: "class E G-protein coupled receptor" BROAD [] synonym: "class E GPCR" BROAD [] synonym: "cyclic AMP receptor activity" EXACT [] is_a: GO:0001614 ! purinergic nucleotide receptor activity [Term] id: GO:0001647 name: G-protein coupled cytokinin receptor activity namespace: molecular_function def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled cytokinin receptor activity" EXACT [] synonym: "G-protein-coupled cytokinin receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0001648 name: proteinase activated receptor activity namespace: molecular_function def: "A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985] is_a: GO:0008528 ! G-protein coupled peptide receptor activity [Term] id: GO:0001649 name: osteoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] synonym: "osteoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001503 ! ossification [Term] id: GO:0001650 name: fibrillar center namespace: cellular_component def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] synonym: "fibrillar centre" EXACT [] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001651 name: dense fibrillar component namespace: cellular_component def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] synonym: "pars fibrosa" BROAD [NIF_Subcellular:sao1841764412] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001652 name: granular component namespace: cellular_component def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] synonym: "pars granulosa" BROAD [NIF_Subcellular:sao1217793903] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development [Term] id: GO:0001656 name: metanephros development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] is_a: GO:0001822 ! kidney development [Term] id: GO:0001657 name: ureteric bud development namespace: biological_process def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0035295 ! tube development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0001658 name: branching involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] synonym: "ureteric bud branching" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001660 name: fever generation namespace: biological_process def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl] synonym: "pyrexia" BROAD [] xref: Wikipedia:Fever is_a: GO:0006953 ! acute-phase response is_a: GO:0031649 ! heat generation [Term] id: GO:0001661 name: conditioned taste aversion namespace: biological_process def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] xref: Wikipedia:Conditioned_taste_aversion xref: Wikipedia:Taste_aversion is_a: GO:0007631 ! feeding behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0001662 name: behavioral fear response namespace: biological_process def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] synonym: "behavioural fear response" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0042596 ! fear response is_a: GO:0044708 ! single-organism behavior [Term] id: GO:0001664 name: G-protein coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein-coupled receptor binding" EXACT [GOC:bf] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:REACT_21309 "Activation of GRIK3 homomer, Homo sapiens" is_a: GO:0005102 ! receptor binding [Term] id: GO:0001665 name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] xref: EC:2.4.99.3 xref: MetaCyc:2.4.99.3-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to lowered oxygen tension" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001669 name: acrosomal vesicle namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732] synonym: "acrosomal granule" EXACT [GOC:sart] synonym: "acrosome" RELATED [GOC:dph] xref: Wikipedia:Acrosome is_a: GO:0030141 ! secretory granule [Term] id: GO:0001671 name: ATPase activator activity namespace: molecular_function def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp] synonym: "ATPase stimulator activity" EXACT [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0001672 name: regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:0033044 ! regulation of chromosome organization relationship: regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0001673 name: male germ cell nucleus namespace: cellular_component alt_id: GO:0043081 def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] synonym: "male germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001676 name: long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp] subset: gosubset_prok synonym: "long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] subset: gosubset_prok synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001678 name: cellular glucose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0001680 name: tRNA 3'-terminal CCA addition namespace: biological_process def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [EC:2.7.7.72, GOC:go_curators] subset: gosubset_prok synonym: "-C-C-A pyrophosphorylase activity" RELATED [EC:2.7.7.72] synonym: "ATP(CTP)-tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CCA tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CCA-adding enzyme activity" EXACT [EC:2.7.7.72] synonym: "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity" EXACT [EC:2.7.7.72] synonym: "CTP(ATP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CTP:tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity" EXACT [EC:2.7.7.72] synonym: "ribonucleic cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate adenyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate adenylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "transfer ribonucleic acid nucleotidyl transferase activity" BROAD [EC:2.7.7.72] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase activity" RELATED [EC:2.7.7.72] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "transfer RNA adenylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer-RNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "tRNA adenylyl(cytidylyl)transferase activity" BROAD [EC:2.7.7.72] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72] synonym: "tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72] xref: EC:2.7.7.72 xref: KEGG:R09382 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0042780 ! tRNA 3'-end processing [Term] id: GO:0001681 name: sialate O-acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] subset: gosubset_prok synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] xref: EC:3.1.1.53 xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0001682 name: tRNA 5'-leader removal namespace: biological_process def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] subset: gosubset_prok synonym: "tRNA 5' leader removal" EXACT [] is_a: GO:0008033 ! tRNA processing [Term] id: GO:0001683 name: axonemal dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001684 name: axonemal dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001685 name: axonemal dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001686 name: axonemal dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001687 name: cytoplasmic dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001688 name: cytoplasmic dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001689 name: cytoplasmic dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001690 name: cytoplasmic dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001691 name: pseudophosphatase activity namespace: molecular_function def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] is_a: GO:0019212 ! phosphatase inhibitor activity [Term] id: GO:0001692 name: histamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process [Term] id: GO:0001694 name: histamine biosynthetic process namespace: biological_process alt_id: GO:0001693 def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine anabolism" EXACT [] synonym: "histamine biosynthesis" EXACT [] synonym: "histamine formation" EXACT [] synonym: "histamine synthesis" EXACT [] xref: Reactome:REACT_115661 "Histidine is decarboxylated to histamine, Homo sapiens" is_a: GO:0001692 ! histamine metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0001695 name: histamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine breakdown" EXACT [] synonym: "histamine catabolism" EXACT [] synonym: "histamine degradation" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001697 name: histamine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001698 name: gastrin-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001699 name: acetylcholine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development [Term] id: GO:0001702 name: gastrulation with mouth forming second namespace: biological_process alt_id: GO:0010003 alt_id: GO:0048276 def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "deuterostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001703 name: gastrulation with mouth forming first namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "protostomic gastrulation" NARROW [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007492 ! endoderm development [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0001708 name: cell fate specification namespace: biological_process def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001709 name: cell fate determination namespace: biological_process def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] xref: Wikipedia:Cell_fate_determination is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001710 name: mesodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] synonym: "mesoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0048333 ! mesodermal cell differentiation [Term] id: GO:0001711 name: endodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] synonym: "endoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0035987 ! endodermal cell differentiation [Term] id: GO:0001712 name: ectodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0001705 ! ectoderm formation relationship: part_of GO:0010668 ! ectodermal cell differentiation [Term] id: GO:0001713 name: ectodermal cell fate determination namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001714 name: endodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "endoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0001715 name: ectodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "ectoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001716 name: L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2] subset: gosubset_prok synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] xref: EC:1.4.3.2 xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN xref: RHEA:13784 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0001717 name: conversion of seryl-tRNAsec to selenocys-tRNAsec namespace: biological_process def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X] subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001720 name: conversion of lysyl-tRNA to pyrrolysyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001721 name: intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "IFAP" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001722 name: type I intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001723 name: type II intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001724 name: type III intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0001725 name: stress fiber namespace: cellular_component def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] synonym: "actin cable" RELATED [GOC:mah] synonym: "stress fibre" EXACT [] is_a: GO:0032432 ! actin filament bundle is_a: GO:0042641 ! actomyosin [Term] id: GO:0001726 name: ruffle namespace: cellular_component def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] synonym: "membrane ruffle" RELATED [] is_a: GO:0042995 ! cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0001727 name: lipid kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] subset: gosubset_prok is_a: GO:0016301 ! kinase activity [Term] id: GO:0001729 name: ceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] xref: EC:2.7.1.138 xref: MetaCyc:CERAMIDE-KINASE-RXN xref: Reactome:REACT_116045 "Ceramide kinase (CERK) mediates the phosphorylation of ceramide, Homo sapiens" xref: RHEA:17932 is_a: GO:0001727 ! lipid kinase activity [Term] id: GO:0001730 name: 2'-5'-oligoadenylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732] synonym: "(2-5')oligo(A) synthetase activity" EXACT [] synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] synonym: "2-5A synthetase activity" EXACT [] synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] xref: MetaCyc:RXN-10798 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0001731 name: formation of translation preinitiation complex namespace: biological_process def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. subset: gosubset_prok synonym: "formation of translation pre-initiation complex" EXACT [] synonym: "translation preinitiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001732 name: formation of translation initiation complex namespace: biological_process def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] subset: gosubset_prok synonym: "translation initiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001733 name: galactosylceramide sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "cerebroside sulfotransferase activity" EXACT [] synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactosylceramide sulphotransferase activity" EXACT [] synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "GSase" EXACT [EC:2.8.2.11] xref: EC:2.8.2.11 xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN xref: Reactome:REACT_115577 "Galactosylceramide sulfotransferase (GAL3ST1) mediates the sulfation of membrane glycolipids, Homo sapiens" xref: RHEA:20616 is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity [Term] id: GO:0001734 name: mRNA (N6-adenosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd] xref: Reactome:REACT_101890 "Internal Methylation of mRNA, Oryza sativa" xref: Reactome:REACT_1720 "Internal Methylation of mRNA, Homo sapiens" xref: Reactome:REACT_28538 "Internal Methylation of mRNA, Canis familiaris" xref: Reactome:REACT_28726 "Internal Methylation of mRNA, Arabidopsis thaliana" xref: Reactome:REACT_30916 "Internal Methylation of mRNA, Drosophila melanogaster" xref: Reactome:REACT_32129 "Internal Methylation of mRNA, Rattus norvegicus" xref: Reactome:REACT_85371 "Internal Methylation of mRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_88666 "Internal Methylation of mRNA, Mus musculus" xref: Reactome:REACT_90117 "Internal Methylation of mRNA, Bos taurus" xref: Reactome:REACT_91818 "Internal Methylation of mRNA, Plasmodium falciparum" xref: Reactome:REACT_92618 "Internal Methylation of mRNA, Danio rerio" xref: Reactome:REACT_96892 "Internal Methylation of mRNA, Xenopus tropicalis" is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0001735 name: prenylcysteine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd] synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] xref: EC:1.8.3.5 xref: MetaCyc:1.8.3.5-RXN is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0001736 name: establishment of planar polarity namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] synonym: "establishment of planar cell polarity" NARROW [] is_a: GO:0007164 ! establishment of tissue polarity relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0001737 name: establishment of imaginal disc-derived wing hair orientation namespace: biological_process def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] synonym: "establishment of wing hair orientation" EXACT [] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0001738 name: morphogenesis of a polarized epithelium namespace: biological_process def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] synonym: "epithelial polarization" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732] is_a: GO:0005720 ! nuclear heterochromatin relationship: part_of GO:0000803 ! sex chromosome [Term] id: GO:0001740 name: Barr body namespace: cellular_component def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] xref: Wikipedia:Barr_body is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000805 ! X chromosome [Term] id: GO:0001741 name: XY body namespace: cellular_component def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] is_a: GO:0000803 ! sex chromosome [Term] id: GO:0001742 name: oenocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] synonym: "oenocyte cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0001743 name: optic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048598 ! embryonic morphogenesis [Term] id: GO:0001744 name: optic lobe placode formation namespace: biological_process alt_id: GO:0007457 def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] is_a: GO:0001743 ! optic placode formation relationship: part_of GO:0001748 ! optic lobe placode development [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0001746 name: Bolwig's organ morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0055034 ! Bolwig's organ development [Term] id: GO:0001748 name: optic lobe placode development namespace: biological_process alt_id: GO:0048049 def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] synonym: "optic placode development" BROAD [] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0001750 name: photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820] is_a: GO:0031513 ! nonmotile primary cilium [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0001752 name: compound eye photoreceptor fate commitment namespace: biological_process alt_id: GO:0007459 def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0001753 name: adult eye photoreceptor development (sensu Drosophila) namespace: biological_process def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. is_obsolete: true consider: GO:0042051 [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0046530 ! photoreceptor cell differentiation relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0001667 ! ameboidal cell migration relationship: part_of GO:0014032 ! neural crest cell development [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0001757 name: somite specification namespace: biological_process def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph] is_a: GO:0007379 ! segment specification is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0001758 name: retinal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] xref: EC:1.2.1.36 xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN xref: RHEA:16180 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0001759 name: organ induction namespace: biological_process def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] synonym: "induction of an organ" EXACT [GOC:curators] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0031128 ! developmental induction is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0010092 ! specification of organ identity [Term] id: GO:0001760 name: aminocarboxymuconate-semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16560] subset: gosubset_prok synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] xref: EC:4.1.1.45 xref: KEGG:R04323 xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN xref: RHEA:16560 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0001761 name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0001762 name: beta-alanine transport namespace: biological_process def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0044767 ! single-organism developmental process [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [GOC:go_curators] synonym: "neuron chemotaxis" EXACT [GOC:curators] synonym: "neuron guidance" RELATED [GOC:curators] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0001765 name: membrane raft assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] synonym: "lipid raft assembly" EXACT [GOC:mah] synonym: "lipid raft formation" RELATED [] synonym: "membrane raft formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031579 ! membrane raft organization [Term] id: GO:0001766 name: membrane raft polarization namespace: biological_process def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889] synonym: "lipid raft polarization" EXACT [] is_a: GO:0031580 ! membrane raft distribution [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042110 ! T cell activation [Term] id: GO:0001769 name: establishment of B cell polarity namespace: biological_process def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. synonym: "B cell polarization" EXACT [] synonym: "B lymphocyte polarization" EXACT [] synonym: "B-cell polarization" EXACT [] synonym: "establishment of B lymphocyte polarity" EXACT [] synonym: "establishment of B-cell polarity" EXACT [] synonym: "establishment of B-lymphocyte polarity" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042113 ! B cell activation [Term] id: GO:0001770 name: establishment of natural killer cell polarity namespace: biological_process def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] synonym: "establishment of NK cell polarity" EXACT [] synonym: "natural killer cell polarization" EXACT [] synonym: "NK cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0030101 ! natural killer cell activation [Term] id: GO:0001771 name: immunological synapse formation namespace: biological_process def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] synonym: "formation of immunological synapse" EXACT [GOC:curators] is_a: GO:0009988 ! cell-cell recognition relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001772 name: immunological synapse namespace: cellular_component def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] synonym: "c-SMAC" NARROW [PMID:14724296] synonym: "supramolecular activation cluster" EXACT [PMID:14724296] xref: Wikipedia:Immunological_synapse is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0042116 ! macrophage activation [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0044763 ! single-organism cellular process [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0001778 name: plasma membrane repair namespace: biological_process def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0001779 name: natural killer cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development" RELATED [GOC:add] synonym: "NK cell differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0001780 name: neutrophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266] comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0001781 name: neutrophil apoptotic process namespace: biological_process def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266] synonym: "apoptosis of neutrophils" EXACT [] synonym: "neutrophil apoptosis" NARROW [] synonym: "neutrophil programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] synonym: "programmed cell death, neutrophils" EXACT [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process relationship: part_of GO:0001780 ! neutrophil homeostasis [Term] id: GO:0001782 name: B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429] comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "B lymphocyte homeostasis" EXACT [] synonym: "B-cell homeostasis" EXACT [] synonym: "B-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0001783 name: B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of B cells" EXACT [] synonym: "apoptosis of B lymphocytes" EXACT [] synonym: "apoptosis of B-cells" EXACT [] synonym: "apoptosis of B-lymphocytes" EXACT [] synonym: "B cell apoptosis" NARROW [] synonym: "B cell programmed cell death by apoptosis" EXACT [] synonym: "B lymphocyte apoptosis" EXACT [] synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "B-cell apoptosis" EXACT [] synonym: "B-cell programmed cell death by apoptosis" EXACT [] synonym: "B-lymphocyte apoptosis" EXACT [] synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of B cells by apoptosis" EXACT [] synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of B-cells by apoptosis" EXACT [] synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, B cells" EXACT [] synonym: "programmed cell death, B lymphocytes" EXACT [] synonym: "programmed cell death, B-cells" EXACT [] synonym: "programmed cell death, B-lymphocytes" EXACT [] is_a: GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0001784 name: phosphotyrosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0001785 name: prostaglandin J receptor activity namespace: molecular_function def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] synonym: "PGJ receptor activity" RELATED [] synonym: "PGJ(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0001786 name: phosphatidylserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961] is_a: GO:0005543 ! phospholipid binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0001787 name: natural killer cell proliferation namespace: biological_process def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149] synonym: "NK cell proliferation" EXACT [] is_a: GO:0030101 ! natural killer cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0001788 name: antibody-dependent cellular cytotoxicity namespace: biological_process def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795] synonym: "ADCC" EXACT [] synonym: "antibody dependent cell death" EXACT [] synonym: "antibody dependent cell killing" EXACT [] synonym: "antibody-dependent cell death" EXACT [] synonym: "antibody-dependent cell killing" EXACT [] synonym: "type VI hypersensitivity" EXACT [] xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity is_a: GO:0001794 ! type IIa hypersensitivity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0044699 ! single-organism process [Term] id: GO:0001789 name: G-protein coupled receptor signaling pathway, coupled to S1P second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of sphingosine kinase and a subsequent increase in cellular levels of sphingosine-1-phosphate (S1P)." [GOC:dph, GOC:signaling, PMID:14592418] synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "GPCR signaling pathway via activation of sphingosine kinase activity" EXACT [GOC:signaling] synonym: "sphingosine kinase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling] synonym: "sphingosine kinase-activating GPCR signaling pathway" EXACT [GOC:signaling] is_a: GO:0007186 ! G-protein coupled receptor signaling pathway [Term] id: GO:0001790 name: polymeric immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001791 name: IgM binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001792 name: polymeric immunoglobulin receptor activity namespace: molecular_function def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001793 name: IgM receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001794 name: type IIa hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149] comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001795 name: type IIb hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. synonym: "type V hypersensitivity" EXACT [] is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001796 name: regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001797 name: negative regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IIa hypersensitivity" EXACT [] synonym: "down-regulation of type IIa hypersensitivity" EXACT [] synonym: "downregulation of type IIa hypersensitivity" EXACT [] synonym: "inhibition of type IIa hypersensitivity" NARROW [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001798 name: positive regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IIa hypersensitivity" NARROW [] synonym: "stimulation of type IIa hypersensitivity" NARROW [] synonym: "up regulation of type IIa hypersensitivity" EXACT [] synonym: "up-regulation of type IIa hypersensitivity" EXACT [] synonym: "upregulation of type IIa hypersensitivity" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001799 name: regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001800 name: negative regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IIb hypersensitivity" EXACT [] synonym: "down-regulation of type IIb hypersensitivity" EXACT [] synonym: "downregulation of type IIb hypersensitivity" EXACT [] synonym: "inhibition of type IIb hypersensitivity" NARROW [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001801 name: positive regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IIb hypersensitivity" NARROW [] synonym: "stimulation of type IIb hypersensitivity" NARROW [] synonym: "up regulation of type IIb hypersensitivity" EXACT [] synonym: "up-regulation of type IIb hypersensitivity" EXACT [] synonym: "upregulation of type IIb hypersensitivity" EXACT [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001802 name: type III hypersensitivity namespace: biological_process def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149] comment: Note that the Arthus reaction is an example of type III hypersensitivity. xref: Wikipedia:Type_III_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0001803 name: regulation of type III hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001804 name: negative regulation of type III hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type III hypersensitivity" EXACT [] synonym: "down-regulation of type III hypersensitivity" EXACT [] synonym: "downregulation of type III hypersensitivity" EXACT [] synonym: "inhibition of type III hypersensitivity" NARROW [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001805 name: positive regulation of type III hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type III hypersensitivity" NARROW [] synonym: "stimulation of type III hypersensitivity" NARROW [] synonym: "up regulation of type III hypersensitivity" EXACT [] synonym: "up-regulation of type III hypersensitivity" EXACT [] synonym: "upregulation of type III hypersensitivity" EXACT [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001806 name: type IV hypersensitivity namespace: biological_process alt_id: GO:0016069 def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149] synonym: "delayed hypersensitivity response" EXACT [] synonym: "delayed-type hypersensitivity" EXACT [] xref: Wikipedia:Type_IV_hypersensitivity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002524 ! hypersensitivity [Term] id: GO:0001807 name: regulation of type IV hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002883 ! regulation of hypersensitivity relationship: regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001808 name: negative regulation of type IV hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IV hypersensitivity" EXACT [] synonym: "down-regulation of type IV hypersensitivity" EXACT [] synonym: "downregulation of type IV hypersensitivity" EXACT [] synonym: "inhibition of type IV hypersensitivity" NARROW [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002884 ! negative regulation of hypersensitivity relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001809 name: positive regulation of type IV hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IV hypersensitivity" NARROW [] synonym: "stimulation of type IV hypersensitivity" NARROW [] synonym: "up regulation of type IV hypersensitivity" EXACT [] synonym: "up-regulation of type IV hypersensitivity" EXACT [] synonym: "upregulation of type IV hypersensitivity" EXACT [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002885 ! positive regulation of hypersensitivity relationship: positively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001810 name: regulation of type I hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001811 name: negative regulation of type I hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type I hypersensitivity" EXACT [] synonym: "down-regulation of type I hypersensitivity" EXACT [] synonym: "downregulation of type I hypersensitivity" EXACT [] synonym: "inhibition of type I hypersensitivity" NARROW [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001812 name: positive regulation of type I hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type I hypersensitivity" NARROW [] synonym: "stimulation of type I hypersensitivity" NARROW [] synonym: "up regulation of type I hypersensitivity" EXACT [] synonym: "up-regulation of type I hypersensitivity" EXACT [] synonym: "upregulation of type I hypersensitivity" EXACT [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001813 name: regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of antibody dependent cell death" EXACT [] synonym: "regulation of antibody dependent cell killing" EXACT [] synonym: "regulation of antibody-dependent cell death" EXACT [] synonym: "regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001814 name: negative regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "negative regulation of antibody dependent cell death" EXACT [] synonym: "negative regulation of antibody dependent cell killing" EXACT [] synonym: "negative regulation of antibody-dependent cell death" EXACT [] synonym: "negative regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001815 name: positive regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "positive regulation of antibody dependent cell death" EXACT [] synonym: "positive regulation of antibody dependent cell killing" EXACT [] synonym: "positive regulation of antibody-dependent cell death" EXACT [] synonym: "positive regulation of antibody-dependent cell killing" EXACT [] synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. subset: goslim_pir synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah] is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0001816 ! cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine production" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "activation of cytokine production" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion namespace: biological_process def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149] is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001822 name: kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] synonym: "nephrogenesis" RELATED [GOC:dph, GOC:tb] xref: Wikipedia:Kidney_development is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048513 ! organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0001823 name: mesonephros development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314] is_a: GO:0001822 ! kidney development [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001701 ! in utero embryonic development [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001827 name: inner cell mass cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0044767 ! single-organism developmental process is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001828 name: inner cell mass cellular morphogenesis namespace: biological_process def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001830 name: trophectodermal cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell fate commitment" EXACT [] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001835 name: blastocyst hatching namespace: biological_process def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. is_a: GO:0035188 ! hatching relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001836 name: release of cytochrome c from mitochondria namespace: biological_process def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. is_a: GO:0008637 ! apoptotic mitochondrial changes relationship: part_of GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0014031 ! mesenchymal cell development [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001840 ! neural plate development [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001843 name: neural tube closure namespace: biological_process def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] is_a: GO:0060606 ! tube closure relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001844 name: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway namespace: biological_process def: "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892] comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [] synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:dph, GOC:tb] synonym: "protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [] synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [] xref: Reactome:REACT_101395 "Translocation of BMF to mitochondria, Gallus gallus" xref: Reactome:REACT_101818 "Translocation of BIM to mitochondria, Sus scrofa" xref: Reactome:REACT_102379 "Translocation of BIM to mitochondria, Bos taurus" xref: Reactome:REACT_104 "Translocation of PUMA protein to mitochondria, Homo sapiens" xref: Reactome:REACT_105818 "Translocation of BIM to mitochondria, Rattus norvegicus" xref: Reactome:REACT_105883 "Translocation of activated BAD protein to mitochondria, Bos taurus" xref: Reactome:REACT_109143 "Translocation of activated BAX to the mitochondria, Danio rerio" xref: Reactome:REACT_110253 "Translocation of BMF to mitochondria, Taeniopygia guttata" xref: Reactome:REACT_110902 "Translocation of activated BAD protein to mitochondria, Sus scrofa" xref: Reactome:REACT_112264 "Translocation of activated BAD protein to mitochondria, Xenopus tropicalis" xref: Reactome:REACT_112484 "Translocation of NOXA to mitochondria, Mus musculus" xref: Reactome:REACT_112773 "Translocation of NOXA to mitochondria, Rattus norvegicus" xref: Reactome:REACT_113120 "Translocation of BIM to mitochondria, Xenopus tropicalis" xref: Reactome:REACT_113968 "Translocation of NOXA to mitochondria, Sus scrofa" xref: Reactome:REACT_115488 "Translocation of NOXA to mitochondria, Canis familiaris" xref: Reactome:REACT_1286 "Translocation of activated BAX to the mitochondria, Homo sapiens" xref: Reactome:REACT_1585 "Translocation of NOXA to mitochondria, Homo sapiens" xref: Reactome:REACT_2046 "Translocation of activated BAD protein to mitochondria, Homo sapiens" xref: Reactome:REACT_32202 "Translocation of activated BAX to the mitochondria, Xenopus tropicalis" xref: Reactome:REACT_32704 "Translocation of activated BAD protein to mitochondria, Canis familiaris" xref: Reactome:REACT_600 "Translocation of BMF to mitochondria, Homo sapiens" xref: Reactome:REACT_750 "Translocation of BIM to mitochondria, Homo sapiens" xref: Reactome:REACT_78961 "Translocation of activated BAD protein to mitochondria, Danio rerio" xref: Reactome:REACT_81932 "Translocation of activated BAX to the mitochondria, Bos taurus" xref: Reactome:REACT_83771 "Translocation of BMF to mitochondria, Bos taurus" xref: Reactome:REACT_85921 "Translocation of BIM to mitochondria, Canis familiaris" xref: Reactome:REACT_87251 "Translocation of activated BAD protein to mitochondria, Rattus norvegicus" xref: Reactome:REACT_87865 "Translocation of activated BAX to the mitochondria, Rattus norvegicus" xref: Reactome:REACT_89314 "Translocation of BMF to mitochondria, Rattus norvegicus" xref: Reactome:REACT_91622 "Translocation of activated BAD protein to mitochondria, Mus musculus" xref: Reactome:REACT_92580 "Translocation of activated BAX to the mitochondria, Mus musculus" xref: Reactome:REACT_94530 "Translocation of BMF to mitochondria, Mus musculus" xref: Reactome:REACT_95929 "Translocation of BIM to mitochondria, Mus musculus" xref: Reactome:REACT_97369 "Translocation of activated BAX to the mitochondria, Taeniopygia guttata" xref: Reactome:REACT_97409 "Translocation of activated BAX to the mitochondria, Sus scrofa" xref: Reactome:REACT_97453 "Translocation of BMF to mitochondria, Canis familiaris" xref: Reactome:REACT_99030 "Translocation of activated BAX to the mitochondria, Canis familiaris" xref: Reactome:REACT_99700 "Translocation of BMF to mitochondria, Xenopus tropicalis" is_a: GO:0051204 ! protein insertion into mitochondrial membrane relationship: part_of GO:0097190 ! apoptotic signaling pathway relationship: part_of GO:0097345 ! mitochondrial outer membrane permeabilization [Term] id: GO:0001845 name: phagolysosome assembly namespace: biological_process def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149] synonym: "late phagosome biosynthesis" RELATED [] synonym: "late phagosome formation" RELATED [] synonym: "phagolysosome formation" RELATED [GOC:mah] is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0090382 ! phagosome maturation [Term] id: GO:0001846 name: opsonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149] comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. is_a: GO:0005515 ! protein binding [Term] id: GO:0001847 name: opsonin receptor activity namespace: molecular_function def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0001848 name: complement binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0005515 ! protein binding [Term] id: GO:0001849 name: complement component C1q binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001850 name: complement component C3a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001851 name: complement component C3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001852 name: complement component iC3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001853 name: complement component C3dg binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001854 name: complement component C3d binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001855 name: complement component C4b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001856 name: complement component C5a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001857 name: complement component C1q receptor activity namespace: molecular_function def: "Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001858 name: complement component iC3b receptor activity namespace: molecular_function def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001859 name: complement component C3dg receptor activity namespace: molecular_function def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001860 name: complement component C3d receptor activity namespace: molecular_function def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001861 name: complement component C4b receptor activity namespace: molecular_function def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001862 name: collectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149] comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001863 name: collectin receptor activity namespace: molecular_function def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001847 ! opsonin receptor activity [Term] id: GO:0001864 name: pentraxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001865 name: NK T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer T cell differentiation" EXACT [] synonym: "natural T cell differentiation" EXACT [] synonym: "NK T cell development" RELATED [GOC:add] synonym: "NK T lymphocyte differentiation" EXACT [] synonym: "NK T-cell differentiation" EXACT [] synonym: "NK T-lymphocyte differentiation" EXACT [] synonym: "NKT cell differentiation" EXACT [] synonym: "NT cell differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0001866 name: NK T cell proliferation namespace: biological_process def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell proliferation" EXACT [] synonym: "natural T cell proliferation" EXACT [] synonym: "NK T lymphocyte proliferation" EXACT [] synonym: "NK T-cell proliferation" EXACT [] synonym: "NK T-lymphocyte proliferation" EXACT [] synonym: "NKT cell proliferation" EXACT [] synonym: "NT cell proliferation" EXACT [] is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0001867 name: complement activation, lectin pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. synonym: "complement cascade, lectin pathway" EXACT [GOC:add] xref: Reactome:REACT_114752 "Lectin pathway of complement activation, Canis familiaris" xref: Reactome:REACT_30334 "Lectin pathway of complement activation, Rattus norvegicus" xref: Reactome:REACT_31122 "Lectin pathway of complement activation, Bos taurus" xref: Reactome:REACT_33084 "Lectin pathway of complement activation, Mus musculus" xref: Reactome:REACT_7964 "Lectin pathway of complement activation, Homo sapiens" xref: Reactome:REACT_89631 "Lectin pathway of complement activation, Sus scrofa" xref: Reactome:REACT_96749 "Lectin pathway of complement activation, Gallus gallus" is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0001868 name: regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149] synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001869 name: negative regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] synonym: "down regulation of complement activation, lectin pathway" EXACT [] synonym: "down-regulation of complement activation, lectin pathway" EXACT [] synonym: "downregulation of complement activation, lectin pathway" EXACT [] synonym: "inhibition of complement activation, lectin pathway" NARROW [] synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001870 name: positive regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] synonym: "activation of complement activation, lectin pathway" NARROW [] synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, lectin pathway" NARROW [] synonym: "up regulation of complement activation, lectin pathway" EXACT [] synonym: "up-regulation of complement activation, lectin pathway" EXACT [] synonym: "upregulation of complement activation, lectin pathway" EXACT [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001871 name: pattern binding namespace: molecular_function def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead. subset: goslim_pir subset: gosubset_prok synonym: "pattern recognition activity" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0001872 name: (1->3)-beta-D-glucan binding namespace: molecular_function alt_id: GO:0080087 def: "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091] synonym: "1,3-beta-D-glucan binding" EXACT [] synonym: "callose binding" NARROW [] synonym: "zymosan binding" NARROW [GOC:tb] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001873 name: polysaccharide receptor activity namespace: molecular_function def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091] is_a: GO:0008329 ! pattern recognition receptor activity [Term] id: GO:0001874 name: (1->3)-beta-D-glucan receptor activity namespace: molecular_function def: "Combining with (1->3)-beta-D-glucans to initiate a change in cell activity." [PMID:14707091] synonym: "(1,3)-beta-D-glucan receptor activity" EXACT [] synonym: "1,3-beta-D-glucan receptor activity" EXACT [] synonym: "beta-1,3-D-glucan receptor activity" EXACT [] synonym: "zymosan receptor activity" NARROW [GOC:tb] is_a: GO:0001873 ! polysaccharide receptor activity [Term] id: GO:0001875 name: lipopolysaccharide receptor activity namespace: molecular_function def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] synonym: "endotoxin receptor activity" BROAD [] synonym: "LPS receptor activity" EXACT [] is_a: GO:0008329 ! pattern recognition receptor activity [Term] id: GO:0001876 name: lipoarabinomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073] synonym: "LAM binding" EXACT [] is_a: GO:0001871 ! pattern binding is_a: GO:0034235 ! GPI anchor binding [Term] id: GO:0001877 name: lipoarabinomannan receptor activity namespace: molecular_function def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073] synonym: "LAM receptor activity" EXACT [] is_a: GO:0008329 ! pattern recognition receptor activity [Term] id: GO:0001878 name: response to yeast namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] is_a: GO:0009620 ! response to fungus [Term] id: GO:0001879 name: detection of yeast namespace: biological_process def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] is_a: GO:0001878 ! response to yeast is_a: GO:0016046 ! detection of fungus [Term] id: GO:0001880 name: Mullerian duct regression namespace: biological_process def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0001881 name: receptor recycling namespace: biological_process def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] is_a: GO:0043112 ! receptor metabolic process relationship: part_of GO:0023051 ! regulation of signaling [Term] id: GO:0001882 name: nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0001883 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001884 name: pyrimidine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0045446 ! endothelial cell differentiation [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0001885 ! endothelial cell development [Term] id: GO:0001887 name: selenium compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456] subset: gosubset_prok synonym: "selenium compound metabolism" EXACT [] synonym: "selenium metabolic process" EXACT [] synonym: "selenium metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0001888 name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] xref: EC:2.4.1.223 xref: MetaCyc:2.4.1.223-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048513 ! organ development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0001890 name: placenta development namespace: biological_process def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048513 ! organ development [Term] id: GO:0001891 name: phagocytic cup namespace: cellular_component def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001892 name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "fetal placenta development" EXACT [GOC:dph] is_a: GO:0048568 ! embryonic organ development relationship: part_of GO:0001701 ! in utero embryonic development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001893 name: maternal placenta development namespace: biological_process def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "decidua development" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development is_a: GO:0060135 ! maternal process involved in female pregnancy relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: part_of GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001895 name: retina homeostasis namespace: biological_process def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0001896 name: autolysis namespace: biological_process def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add] subset: gosubset_prok xref: Wikipedia:Autolysis is_a: GO:0019835 ! cytolysis [Term] id: GO:0001897 name: cytolysis by symbiont of host cells namespace: biological_process def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "cytolysis by organism of host cells" EXACT [] is_a: GO:0001907 ! killing by symbiont of host cells is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0001898 name: regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001899 name: negative regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001900 name: positive regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "activation by symbiont of cytolysis of host cells" NARROW [] synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001905 name: activation of membrane attack complex namespace: biological_process def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149] synonym: "activation of MAC" EXACT [] synonym: "activation of TCC" NARROW [] synonym: "activation of terminal complement complex" NARROW [GOC:add] synonym: "activation of the terminal complement cascade" NARROW [] synonym: "MAC assembly" EXACT [GOC:rl] synonym: "MAC formation" EXACT [GOC:rl] synonym: "membrane attack complex assembly" EXACT [GOC:rl] synonym: "membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0006956 ! complement activation [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir subset: gosubset_prok synonym: "necrosis" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0001907 name: killing by symbiont of host cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok is_a: GO:0044004 ! disruption by symbiont of host cell is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:11911826] comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. synonym: "immune cell mediated cell death" EXACT [] synonym: "immune cell mediated cell killing" EXACT [] synonym: "immune cell mediated cytotoxicity" EXACT [] synonym: "leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001906 ! cell killing is_a: GO:0002252 ! immune effector process [Term] id: GO:0001910 name: regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "regulation of immune cell mediated cell death" EXACT [] synonym: "regulation of immune cell mediated cell killing" EXACT [] synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0031341 ! regulation of cell killing relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001911 name: negative regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0031342 ! negative regulation of cell killing relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001912 name: positive regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0031343 ! positive regulation of cell killing relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001913 name: T cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. synonym: "T cell mediated apoptosis" EXACT [] synonym: "T cell mediated cell death" EXACT [] synonym: "T cell mediated cell killing" EXACT [] synonym: "T cell mediated cytolysis" RELATED [] synonym: "T lymphocyte mediated cytotoxicity" EXACT [] synonym: "T-cell mediated apoptosis" EXACT [] synonym: "T-cell mediated cell death" EXACT [] synonym: "T-cell mediated cell killing" EXACT [] synonym: "T-cell mediated cytotoxicity" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0044699 ! single-organism process [Term] id: GO:0001914 name: regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of T cell mediated apoptosis" EXACT [] synonym: "regulation of T cell mediated cell death" EXACT [] synonym: "regulation of T cell mediated cell killing" EXACT [] synonym: "regulation of T cell mediated cytolysis" RELATED [] synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "regulation of T-cell mediated apoptosis" EXACT [] synonym: "regulation of T-cell mediated cell death" EXACT [] synonym: "regulation of T-cell mediated cell killing" EXACT [] synonym: "regulation of T-cell mediated cytolysis" RELATED [] synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001915 name: negative regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of T cell mediated apoptosis" EXACT [] synonym: "negative regulation of T cell mediated cell death" EXACT [] synonym: "negative regulation of T cell mediated cell killing" EXACT [] synonym: "negative regulation of T cell mediated cytolysis" RELATED [] synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] synonym: "negative regulation of T-cell mediated cell death" EXACT [] synonym: "negative regulation of T-cell mediated cell killing" EXACT [] synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002710 ! negative regulation of T cell mediated immunity relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001916 name: positive regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of T cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of T cell mediated apoptosis" EXACT [] synonym: "positive regulation of T cell mediated cell death" EXACT [] synonym: "positive regulation of T cell mediated cell killing" EXACT [] synonym: "positive regulation of T cell mediated cytolysis" RELATED [] synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] synonym: "positive regulation of T-cell mediated cell death" EXACT [] synonym: "positive regulation of T-cell mediated cell killing" EXACT [] synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002711 ! positive regulation of T cell mediated immunity relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001917 name: photoreceptor inner segment namespace: cellular_component def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] subset: goslim_pir is_a: GO:0044464 ! cell part [Term] id: GO:0001918 name: farnesylated protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765] is_a: GO:0005515 ! protein binding [Term] id: GO:0001919 name: regulation of receptor recycling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] is_a: GO:0023051 ! regulation of signaling is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0001881 ! receptor recycling [Term] id: GO:0001920 name: negative regulation of receptor recycling namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add] synonym: "down regulation of receptor recycling" EXACT [] synonym: "down-regulation of receptor recycling" EXACT [] synonym: "downregulation of receptor recycling" EXACT [] synonym: "inhibition of receptor recycling" NARROW [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0031324 ! negative regulation of cellular metabolic process relationship: negatively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001921 name: positive regulation of receptor recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] synonym: "activation of receptor recycling" NARROW [] synonym: "stimulation of receptor recycling" NARROW [] synonym: "up regulation of receptor recycling" EXACT [] synonym: "up-regulation of receptor recycling" EXACT [] synonym: "upregulation of receptor recycling" EXACT [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0031325 ! positive regulation of cellular metabolic process relationship: positively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001922 name: B-1 B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. synonym: "B-1 B lymphocyte homeostasis" EXACT [] synonym: "B-1 B-cell homeostasis" EXACT [] synonym: "B-1 B-lymphocyte homeostasis" EXACT [] is_a: GO:0001782 ! B cell homeostasis [Term] id: GO:0001923 name: B-1 B cell differentiation namespace: biological_process def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] synonym: "B-1 B cell development" RELATED [GOC:add] synonym: "B-1 B lymphocyte differentiation" EXACT [] synonym: "B-1 B-cell differentiation" EXACT [] synonym: "B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0001924 name: regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B-1 B cell development" RELATED [GOC:add] synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "regulation of B-1 B-cell differentiation" EXACT [] synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001925 name: negative regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B-1 B cell differentiation" EXACT [] synonym: "down-regulation of B-1 B cell differentiation" EXACT [] synonym: "downregulation of B-1 B cell differentiation" EXACT [] synonym: "inhibition of B-1 B cell differentiation" NARROW [] synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add] synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045578 ! negative regulation of B cell differentiation relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001926 name: positive regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B-1 B cell differentiation" NARROW [] synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add] synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B-1 B cell differentiation" NARROW [] synonym: "up regulation of B-1 B cell differentiation" EXACT [] synonym: "up-regulation of B-1 B cell differentiation" EXACT [] synonym: "upregulation of B-1 B cell differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045579 ! positive regulation of B cell differentiation relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001927 name: exocyst assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis [Term] id: GO:0001928 name: regulation of exocyst assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001929 name: negative regulation of exocyst assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd] synonym: "down regulation of exocyst assembly" EXACT [] synonym: "down-regulation of exocyst assembly" EXACT [] synonym: "downregulation of exocyst assembly" EXACT [] synonym: "inhibition of exocyst assembly" NARROW [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031333 ! negative regulation of protein complex assembly relationship: negatively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001930 name: positive regulation of exocyst assembly namespace: biological_process def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] synonym: "activation of exocyst assembly" NARROW [] synonym: "stimulation of exocyst assembly" NARROW [] synonym: "up regulation of exocyst assembly" EXACT [] synonym: "up-regulation of exocyst assembly" EXACT [] synonym: "upregulation of exocyst assembly" EXACT [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031334 ! positive regulation of protein complex assembly relationship: positively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001931 name: uropod namespace: cellular_component def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] synonym: "distal pole complex" RELATED [] synonym: "retractile pole" RELATED [] synonym: "uropodium" EXACT [] is_a: GO:0042995 ! cell projection relationship: part_of GO:0031254 ! trailing edge [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] subset: gosubset_prok synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gosubset_prok synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation relationship: negatively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gosubset_prok synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation relationship: positively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: positively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001939 name: female pronucleus namespace: cellular_component def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001940 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph] synonym: "post-synaptic membrane organization" EXACT [] synonym: "postsynaptic membrane organisation" EXACT [GOC:curators] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0001942 name: hair follicle development namespace: biological_process alt_id: GO:0001943 def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073] is_a: GO:0008544 ! epidermis development is_a: GO:0022405 ! hair cycle process [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [GOC:curators] is_a: GO:0048731 ! system development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0001945 name: lymph vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001946 name: lymphangiogenesis namespace: biological_process def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] synonym: "lymph vessel formation" EXACT systematic_synonym [] xref: Wikipedia:Lymphangiogenesis is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0036303 ! lymph vessel morphogenesis [Term] id: GO:0001947 name: heart looping namespace: biological_process def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232] synonym: "cardiac looping" EXACT [] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0001948 name: glycoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732] is_a: GO:0005515 ! protein binding [Term] id: GO:0001949 name: sebaceous gland cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0048733 ! sebaceous gland development [Term] id: GO:0001950 name: plasma membrane enriched fraction namespace: cellular_component def: "OBSOLETE: The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "PME fraction" RELATED [GOC:mah] is_obsolete: true consider: GO:0005886 [Term] id: GO:0001951 name: intestinal D-glucose absorption namespace: biological_process def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] is_a: GO:0015758 ! glucose transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0001952 name: regulation of cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] is_a: GO:0010810 ! regulation of cell-substrate adhesion relationship: regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001953 name: negative regulation of cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] synonym: "down regulation of cell-matrix adhesion" EXACT [] synonym: "down-regulation of cell-matrix adhesion" EXACT [] synonym: "downregulation of cell-matrix adhesion" EXACT [] synonym: "inhibition of cell-matrix adhesion" NARROW [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010812 ! negative regulation of cell-substrate adhesion relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001954 name: positive regulation of cell-matrix adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] synonym: "activation of cell-matrix adhesion" NARROW [] synonym: "stimulation of cell-matrix adhesion" NARROW [] synonym: "up regulation of cell-matrix adhesion" EXACT [] synonym: "up-regulation of cell-matrix adhesion" EXACT [] synonym: "upregulation of cell-matrix adhesion" EXACT [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010811 ! positive regulation of cell-substrate adhesion relationship: positively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051590 ! positive regulation of neurotransmitter transport relationship: positively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0001958 name: endochondral ossification namespace: biological_process def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437] xref: Wikipedia:Endochondral_ossification is_a: GO:0036075 ! replacement ossification relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0060759 ! regulation of response to cytokine stimulus relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060761 ! negative regulation of response to cytokine stimulus relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060760 ! positive regulation of response to cytokine stimulus relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001962 name: alpha-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427] synonym: "isoglobotriaosylceramide synthase" NARROW [] xref: EC:2.4.1.- is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0001963 name: synaptic transmission, dopaminergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph] is_a: GO:0007270 ! neuron-neuron synaptic transmission [Term] id: GO:0001964 name: startle response namespace: biological_process def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] xref: Wikipedia:Startle_reaction is_a: GO:0009605 ! response to external stimulus is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0001965 name: G-protein alpha-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] synonym: "G-alpha protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0001966 name: thigmotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] synonym: "stereotaxis" EXACT [] synonym: "taxis in response to mechanical stimulus" BROAD [] synonym: "taxis in response to touch stimulus" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0001967 name: suckling behavior namespace: biological_process def: "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph] synonym: "nursing behavior" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0001969 name: regulation of activation of membrane attack complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "regulation of activation of MAC" EXACT [GOC:mah] synonym: "regulation of activation of TCC" NARROW [GOC:mah] synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "regulation of MAC assembly" EXACT [GOC:rl] synonym: "regulation of MAC formation" EXACT [GOC:rl] synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0030449 ! regulation of complement activation relationship: regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001970 name: positive regulation of activation of membrane attack complex namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "activation of activation of membrane attack complex" NARROW [] synonym: "positive regulation of activation of MAC" EXACT [GOC:mah] synonym: "positive regulation of activation of TCC" NARROW [GOC:mah] synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "positive regulation of MAC assembly" EXACT [GOC:rl] synonym: "positive regulation of MAC formation" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl] synonym: "stimulation of activation of membrane attack complex" NARROW [] synonym: "up regulation of activation of membrane attack complex" EXACT [] synonym: "up-regulation of activation of membrane attack complex" EXACT [] synonym: "upregulation of activation of membrane attack complex" EXACT [] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001971 name: negative regulation of activation of membrane attack complex namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "down regulation of activation of membrane attack complex" EXACT [] synonym: "down-regulation of activation of membrane attack complex" EXACT [] synonym: "downregulation of activation of membrane attack complex" EXACT [] synonym: "inhibition of activation of membrane attack complex" NARROW [] synonym: "negative regulation of activation of MAC" EXACT [GOC:mah] synonym: "negative regulation of activation of TCC" NARROW [GOC:mah] synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "negative regulation of MAC assembly" EXACT [GOC:rl] synonym: "negative regulation of MAC formation" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001972 name: retinoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] is_a: GO:0005501 ! retinoid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0001973 name: adenosine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph] synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289] synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah] synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035588 ! G-protein coupled purinergic receptor signaling pathway [Term] id: GO:0001974 name: blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0001975 name: response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef] is_a: GO:0014075 ! response to amine stimulus [Term] id: GO:0001976 name: neurological system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0001977 name: renal system process involved in regulation of blood volume namespace: biological_process def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "renal blood volume control of blood pressure" RELATED [] synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0050878 ! regulation of body fluid levels [Term] id: GO:0001978 name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "baroreceptor feedback control of blood pressure" RELATED [] synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X] synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0001979 name: regulation of systemic arterial blood pressure by chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "chemoreceptor control of blood pressure" RELATED [] synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001980 name: regulation of systemic arterial blood pressure by ischemic conditions namespace: biological_process def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "CNS ischemic response" RELATED [ISBN:0721643949] synonym: "ischemic control of blood pressure" RELATED [] synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001981 name: baroreceptor detection of arterial stretch namespace: biological_process def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0001982 name: baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0001983 name: baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0001984 name: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001985 name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949] synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001986 name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0045822 ! negative regulation of heart contraction relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001987 name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001988 name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001989 name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [] synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process [Term] id: GO:0001991 name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949] synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] synonym: "renin-angiotensin blood pressure control" RELATED [] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0001993 name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949] synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0001994 name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001995 name: norepinephrine-epinephrine catabolic process in blood stream namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] is_a: GO:0042419 ! epinephrine catabolic process relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0001996 name: positive regulation of heart rate by epinephrine-norepinephrine namespace: biological_process def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001997 name: positive regulation of the force of heart contraction by epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] synonym: "increased inotropy by epinephrine-norepinephrine " RELATED [] synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001998 name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949] synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin [Term] id: GO:0001999 name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure namespace: biological_process def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002000 name: detection of renal blood flow namespace: biological_process def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949] is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002001 name: renin secretion into blood stream namespace: biological_process def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949] synonym: "renin release into blood stream" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002002 name: regulation of angiotensin levels in blood namespace: biological_process def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph] synonym: "control of angiotensin levels in blood" RELATED [] synonym: "control of blood angiotensin level" RELATED [] synonym: "regulation of blood angiotensin level" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0060177 ! regulation of angiotensin metabolic process relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002003 name: angiotensin maturation namespace: biological_process def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949] is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002004 name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure namespace: biological_process def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949] synonym: "secretion of vasopressin during fast control of blood pressure" RELATED [] synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0030103 ! vasopressin secretion relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002005 name: angiotensin catabolic process in blood namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949] is_a: GO:0044254 ! multicellular organismal protein catabolic process relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002006 name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002007 name: detection of hypoxic conditions in blood by chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0010850 ! regulation of blood pressure by chemoreceptor signaling pathway is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002008 name: excitation of vasomotor center by chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0002010 name: excitation of vasomotor center by baroreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0002012 name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002013 name: detection of carbon dioxide by vasomotor center namespace: biological_process def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002014 name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure namespace: biological_process def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002015 name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback namespace: biological_process def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "atrial control of blood pressure" RELATED [] synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] synonym: "atrial reflex" RELATED [GOC:dph] is_a: GO:0003015 ! heart process relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0002016 name: regulation of blood volume by renin-angiotensin namespace: biological_process def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "renin-angiotensin control of body fluid levels" RELATED [] synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0002017 name: regulation of blood volume by renal aldosterone namespace: biological_process def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "aldosterone mediated control of body fluids" RELATED [] synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002018 name: renin-angiotensin regulation of aldosterone production namespace: biological_process def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949] synonym: "renin-angiotensin control of aldosterone production" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002019 name: regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "angiotensin mediated control of renal output" RELATED [] synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002020 name: protease binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0002021 name: response to dietary excess namespace: biological_process def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [PMID:12161655] is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0050896 ! response to stimulus relationship: part_of GO:0040014 ! regulation of multicellular organism growth [Term] id: GO:0002022 name: detection of dietary excess namespace: biological_process def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002023 name: reduction of food intake in response to dietary excess namespace: biological_process def: "The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food." [PMID:12161655] is_a: GO:0042755 ! eating behavior relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002024 name: diet induced thermogenesis namespace: biological_process def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002025 name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0002026 name: regulation of the force of heart contraction namespace: biological_process def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] synonym: "heart inotropy" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006814 ! sodium ion transport [Term] id: GO:0002029 name: desensitization of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717] synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] is_a: GO:0022401 ! negative adaptation of signaling pathway is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002030 name: inhibitory G-protein coupled receptor phosphorylation namespace: biological_process def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002031 name: G-protein coupled receptor internalization namespace: biological_process def: "The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle." [PMID:8396717] is_a: GO:0031623 ! receptor internalization relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002032 name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin namespace: biological_process def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway is_a: GO:0032091 ! negative regulation of protein binding [Term] id: GO:0002033 name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951, PMID:10425188] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin [Term] id: GO:0002034 name: regulation of blood vessel size by renin-angiotensin namespace: biological_process def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb] synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin is_a: GO:0050880 ! regulation of blood vessel size [Term] id: GO:0002035 name: brain renin-angiotensin system namespace: biological_process def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002036 name: regulation of L-glutamate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd] is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002037 name: negative regulation of L-glutamate transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd] synonym: "down regulation of L-glutamate transport" EXACT [] synonym: "down-regulation of L-glutamate transport" EXACT [] synonym: "downregulation of L-glutamate transport" EXACT [] synonym: "inhibition of L-glutamate transport" NARROW [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0051956 ! negative regulation of amino acid transport relationship: negatively_regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002038 name: positive regulation of L-glutamate transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd] synonym: "activation of L-glutamate transport" NARROW [] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "upregulation of L-glutamate transport" EXACT [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0051957 ! positive regulation of amino acid transport relationship: positively_regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002039 name: p53 binding namespace: molecular_function def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002040 name: sprouting angiogenesis namespace: biological_process def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002041 name: intussusceptive angiogenesis namespace: biological_process def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002042 name: cell migration involved in sprouting angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002043 name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003] synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0001935 ! endothelial cell proliferation relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002044 name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002045 name: regulation of cell adhesion involved in intussusceptive angiogenesis namespace: biological_process def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002046 name: opsin binding namespace: molecular_function alt_id: GO:0016030 def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] synonym: "metarhodopsin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0002047 name: phenazine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] subset: gosubset_prok synonym: "acridizine biosynthesis" RELATED [] synonym: "acridizine biosynthetic process" RELATED [] synonym: "azophenylene biosynthesis" RELATED [] synonym: "azophenylene biosynthetic process" RELATED [] synonym: "dibenzo-p-diazine biosynthesis" RELATED [] synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] synonym: "dibenzopyrazine biosynthesis" RELATED [] synonym: "dibenzopyrazine biosynthetic process" RELATED [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0002048 name: pyoverdine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] synonym: "pyoverdine metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0002049 name: pyoverdine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0002050 name: pyoverdine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0002051 name: osteoblast fate commitment namespace: biological_process def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation relationship: positively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0002054 name: nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0002055 name: adenine binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd] synonym: "6-aminopurine binding" EXACT [] is_a: GO:0002060 ! purine nucleobase binding [Term] id: GO:0002056 name: cytosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with cytosine." [GOC:hjd, GOC:vw] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002057 name: guanine binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanine." [GOC:hjd] is_a: GO:0002060 ! purine nucleobase binding [Term] id: GO:0002058 name: uracil binding namespace: molecular_function def: "Interacting selectively and non-covalently with uracil." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002059 name: thymine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thymine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002060 name: purine nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton." [CHEBI:26386, GOC:hjd] synonym: "purine base binding" EXACT [GOC:go_curators] synonym: "purine binding" RELATED [GOC:curators] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002061 name: pyrimidine nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [CHEBI:26432, GOC:hjd] synonym: "1,3-diazine binding" NARROW [] synonym: "pyrimidine base binding" EXACT [GOC:go_curators] synonym: "pyrimidine binding" RELATED [GOC:curators] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0002062 ! chondrocyte differentiation [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0002067 ! glandular epithelial cell differentiation [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0002068 ! glandular epithelial cell development [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0002074 name: extraocular skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002075 name: somitomeric trunk muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0002076 name: osteoblast development namespace: biological_process def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002077 name: acrosome matrix dispersal namespace: biological_process def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029] is_a: GO:0048610 ! cellular process involved in reproduction is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002078 name: membrane fusion involved in acrosome reaction namespace: biological_process def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002079 name: inner acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002080 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0002081 name: outer acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002082 name: regulation of oxidative phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy relationship: regulates GO:0006119 ! oxidative phosphorylation [Term] id: GO:0002083 name: 4-hydroxybenzoate decaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230] xref: EC:2.5.1.39 xref: MetaCyc:RXN-9230 is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0002084 name: protein depalmitoylation namespace: biological_process def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] is_a: GO:0035601 ! protein deacylation is_a: GO:0042159 ! lipoprotein catabolic process [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tairtb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0002086 name: diaphragm contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] is_a: GO:0003011 ! involuntary skeletal muscle contraction is_a: GO:0003016 ! respiratory system process [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by neurological system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! neurological system process [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0002090 name: regulation of receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0031623 ! receptor internalization [Term] id: GO:0002091 name: negative regulation of receptor internalization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "down regulation of receptor internalization" EXACT [] synonym: "down-regulation of receptor internalization" EXACT [] synonym: "downregulation of receptor internalization" EXACT [] synonym: "inhibition of receptor internalization" NARROW [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis relationship: negatively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002092 name: positive regulation of receptor internalization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "activation of receptor internalization" NARROW [] synonym: "stimulation of receptor internalization" NARROW [] synonym: "up regulation of receptor internalization" EXACT [] synonym: "up-regulation of receptor internalization" EXACT [] synonym: "upregulation of receptor internalization" EXACT [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis relationship: positively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002093 name: auditory receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] synonym: "hair cell morphogenesis" BROAD [GO:dph] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060117 ! auditory receptor cell development [Term] id: GO:0002094 name: polyprenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] subset: gosubset_prok is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0002095 name: caveolar macromolecular signaling complex namespace: cellular_component def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] synonym: "caveolar macromolecular signalling complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005901 ! caveola [Term] id: GO:0002096 name: polkadots namespace: cellular_component def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0002097 name: tRNA wobble base modification namespace: biological_process def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002098 name: tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002099 name: tRNA wobble guanine modification namespace: biological_process def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002100 name: tRNA wobble adenosine to inosine editing namespace: biological_process def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002101 name: tRNA wobble cytosine modification namespace: biological_process def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002102 name: podosome namespace: cellular_component def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. xref: Wikipedia:Podosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0002103 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0002104 name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002105 name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002106 name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002107 name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III namespace: biological_process def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] is_a: GO:0000481 ! maturation of 5S rRNA is_a: GO:0031125 ! rRNA 3'-end processing [Term] id: GO:0002108 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0002109 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0002110 name: cotranscriptional mitochondrial rRNA nucleotide insertion namespace: biological_process def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965] is_a: GO:0000154 ! rRNA modification is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0002111 name: BRCA2-BRAF35 complex namespace: cellular_component def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0002112 name: interleukin-33 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd] synonym: "IL-33" NARROW [GOC:mah] synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0002113 name: interleukin-33 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd] synonym: "IL-33 binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0002114 name: interleukin-33 receptor activity namespace: molecular_function def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "IL-33 receptor activity" EXACT [GOC:mah] synonym: "IL-33R" EXACT [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0002115 name: store-operated calcium entry namespace: biological_process def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. synonym: "calcium ion import" BROAD [] synonym: "capacitative calcium entry" EXACT [] synonym: "SOCE" EXACT [] synonym: "store-operated calcium import" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0002116 name: semaphorin receptor complex namespace: cellular_component def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] synonym: "plexin-neurophilin complex" EXACT [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0002117 name: amphibian larval development namespace: biological_process def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/] is_a: GO:0002164 ! larval development [Term] id: GO:0002118 name: aggressive behavior namespace: biological_process def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] synonym: "aggression" EXACT [] xref: Wikipedia:Aggression is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002119 name: nematode larval development namespace: biological_process def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] is_a: GO:0002164 ! larval development [Term] id: GO:0002120 name: predatory behavior namespace: biological_process def: "Aggressive behavior involving attack on prey by a predator." [GOC:hjd] synonym: "predatory aggression" EXACT [] synonym: "predatory aggressive behavior" EXACT [] is_a: GO:0002118 ! aggressive behavior is_a: GO:0044366 ! feeding on or from other organism [Term] id: GO:0002121 name: inter-male aggressive behavior namespace: biological_process def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] synonym: "inter-male aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002122 name: fear-induced aggressive behavior namespace: biological_process def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] synonym: "fear-induced aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002123 name: irritable aggressive behavior namespace: biological_process def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] synonym: "irritable aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002124 name: territorial aggressive behavior namespace: biological_process def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] synonym: "territorial aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002125 name: maternal aggressive behavior namespace: biological_process def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] comment: Paternal aggression also exists. Serves to protect the offspring from intruders. synonym: "maternal aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002126 name: instrumental aggressive behavior namespace: biological_process def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] synonym: "instrumental aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002127 name: wobble base cytosine methylation namespace: biological_process def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X] synonym: "wobble position m5C biosynthesis" EXACT [] is_a: GO:0002101 ! tRNA wobble cytosine modification is_a: GO:0002946 ! tRNA C5-cytosine methylation [Term] id: GO:0002128 name: tRNA nucleoside ribose methylation namespace: biological_process def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002129 name: wobble position guanine ribose methylation namespace: biological_process def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation is_a: GO:0002938 ! tRNA guanine ribose methylation [Term] id: GO:0002130 name: wobble position ribose methylation namespace: biological_process def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002131 name: wobble position cytosine ribose methylation namespace: biological_process def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002132 name: wobble position uridine ribose methylation namespace: biological_process def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002133 name: polycystin complex namespace: cellular_component def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144] comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). is_a: GO:0043234 ! protein complex [Term] id: GO:0002134 name: UTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732] is_a: GO:0032551 ! pyrimidine ribonucleoside binding is_a: GO:0032557 ! pyrimidine ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0002135 name: CTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607] is_a: GO:0032551 ! pyrimidine ribonucleoside binding is_a: GO:0032557 ! pyrimidine ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0002136 name: wobble base lysidine biosynthesis namespace: biological_process def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617] comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. is_a: GO:0002101 ! tRNA wobble cytosine modification [Term] id: GO:0002137 name: nuclear cluster namespace: cellular_component def: "Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1)." [PMID:9413993] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0031618 ! nuclear centromeric heterochromatin [Term] id: GO:0002138 name: retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd] synonym: "retinoic acid anabolic process" EXACT [] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042573 ! retinoic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0002139 name: stereocilia coupling link namespace: cellular_component def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142] is_a: GO:0044464 ! cell part [Term] id: GO:0002140 name: stereocilia tip link namespace: cellular_component def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787] is_a: GO:0002139 ! stereocilia coupling link [Term] id: GO:0002141 name: stereocilia ankle link namespace: cellular_component def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809] is_a: GO:0002139 ! stereocilia coupling link [Term] id: GO:0002142 name: stereocilia ankle link complex namespace: cellular_component def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part relationship: part_of GO:0002141 ! stereocilia ankle link [Term] id: GO:0002143 name: tRNA wobble position uridine thiolation namespace: biological_process def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah] synonym: "wobble position s2U biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0034227 ! tRNA thio-modification [Term] id: GO:0002144 name: cytosolic tRNA wobble base thiouridylase complex namespace: cellular_component def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219] synonym: "Cut1-Cut2 complex" NARROW [] synonym: "tRNA thiouridylase" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0002145 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543] synonym: "HMP-PP diphosphatase" EXACT [] synonym: "HMP-PP pyrophosphatase" EXACT [] xref: MetaCyc:RXN0-3543 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0002146 name: steroid hormone receptor import into nucleus namespace: biological_process def: "The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd] comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex. synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0002147 name: glucocorticoid receptor import into nucleus namespace: biological_process def: "The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd] synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah] is_a: GO:0002146 ! steroid hormone receptor import into nucleus relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway [Term] id: GO:0002148 name: hypochlorous acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024] synonym: "HClO metabolic process" EXACT [] synonym: "HOCl metabolic process" EXACT [] synonym: "hypochlorite metabolic process" RELATED [] synonym: "hypochlorous acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0002149 name: hypochlorous acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils. synonym: "HClO biosynthetic process" EXACT [] synonym: "HOCl biosynthetic process" EXACT [] synonym: "hypochlorite biosynthetic process" RELATED [] synonym: "hypochlorous acid biosynthesis" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0002150 name: hypochlorous acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add] synonym: "HClO catabolic process" EXACT [] synonym: "HOCl catabolic process" EXACT [] synonym: "hypochlorite catabolic process" RELATED [] synonym: "hypochlorous acid catabolism" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0002151 name: G-quadruplex RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720] comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. synonym: "G quadruplex binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:hjd] synonym: "G quartet RNA binding" EXACT [GOC:hjd] synonym: "G-quartet binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0002152 name: bile acid conjugation namespace: biological_process def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413] comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). is_a: GO:0008206 ! bile acid metabolic process [Term] id: GO:0002153 name: steroid receptor RNA activator RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993] comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). synonym: "SRA binding" EXACT [] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0002154 name: thyroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd] synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0002155 name: regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002156 name: negative regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002157 name: positive regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0002159 name: desmosome assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0002160 name: desmosome maintenance namespace: biological_process def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0045217 ! cell-cell junction maintenance [Term] id: GO:0002161 name: aminoacyl-tRNA editing activity namespace: molecular_function def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] synonym: "amino acid proofreading activity" RELATED [] synonym: "aminoacyl-tRNA hydrolysis activity" RELATED [] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0002162 name: dystroglycan binding namespace: molecular_function alt_id: GO:0002163 alt_id: GO:0002166 def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd] synonym: "alpha-dystroglycan binding" NARROW [] synonym: "beta-dystroglycan binding" NARROW [] is_a: GO:0001948 ! glycoprotein binding [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002165 name: instar larval or pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002167 name: VRK3/VHR/ERK complex namespace: cellular_component def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380] is_a: GO:0043234 ! protein complex [Term] id: GO:0002168 name: instar larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002164 ! larval development is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0002169 name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial namespace: cellular_component def: "A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:hjd, PMID:15868465] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0002170 name: high affinity IgA receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] is_a: GO:0019766 ! IgA receptor activity [Term] id: GO:0002171 name: low affinity IgA receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] is_a: GO:0019766 ! IgA receptor activity [Term] id: GO:0002172 name: high affinity IgM receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] is_a: GO:0001793 ! IgM receptor activity [Term] id: GO:0002173 name: low affinity IgM receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] is_a: GO:0001793 ! IgM receptor activity [Term] id: GO:0002174 name: mammary stem cell proliferation namespace: biological_process def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0002175 name: protein localization to paranode region of axon namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321] synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0002176 name: male germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd] is_a: GO:0036093 ! germ cell proliferation [Term] id: GO:0002177 name: manchette namespace: cellular_component def: "A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation." [PMID:15018141] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0002178 name: palmitoyltransferase complex namespace: cellular_component def: "A protein complex with palmitoyltransferase activity." [GOC:hjd] is_a: GO:0043234 ! protein complex [Term] id: GO:0002179 name: homodimeric serine palmitoyltransferase complex namespace: cellular_component def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd] comment: This complex occurs primarily in bacteria. is_a: GO:0002178 ! palmitoyltransferase complex [Term] id: GO:0002180 name: 5-lipoxygenase complex namespace: cellular_component def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240] is_a: GO:0043234 ! protein complex is_a: GO:0044453 ! nuclear membrane part [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] subset: goslim_pombe subset: goslim_yeast is_a: GO:0006412 ! translation [Term] id: GO:0002182 name: cytoplasmic translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] is_a: GO:0006414 ! translational elongation relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002184 name: cytoplasmic translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] is_a: GO:0006415 ! translational termination relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002185 name: creatine kinase complex namespace: cellular_component def: "A protein complex having creatine kinase activity." [GOC:hjd] is_a: GO:0043234 ! protein complex [Term] id: GO:0002186 name: cytosolic creatine kinase complex namespace: cellular_component def: "A dimeric protein complex having creatine kinase activity." [PMID:173175] is_a: GO:0002185 ! creatine kinase complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0002187 name: mitochondrial creatine kinase complex namespace: cellular_component def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486] is_a: GO:0002185 ! creatine kinase complex is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0002188 name: translation reinitiation namespace: biological_process def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792] is_a: GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0002189 name: ribose phosphate diphosphokinase complex namespace: cellular_component def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095] comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits. synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095] synonym: "PRPP synthetase complex" EXACT [PMID:9348095] is_a: GO:0043234 ! protein complex [Term] id: GO:0002190 name: cap-independent translational initiation namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590] is_a: GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0002191 name: cap-dependent translational initiation namespace: biological_process def: "The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130] is_a: GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0002192 name: IRES-dependent translational initiation namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590] is_a: GO:0002190 ! cap-independent translational initiation [Term] id: GO:0002193 name: MAML1-RBP-Jkappa- ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869] synonym: "MAML1-CSL-ICN1" EXACT [] synonym: "MAML1-CSL-Notch1 complex" EXACT [] synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: GO:0002194 name: hepatocyte cell migration namespace: biological_process def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819] is_a: GO:0016477 ! cell migration [Term] id: GO:0002195 name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis namespace: biological_process def: "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729] comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli. is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002196 name: Ser-tRNA(Ala) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375] is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] id: GO:0002197 name: xanthine dehydrogenase complex namespace: cellular_component def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915] is_a: GO:0043234 ! protein complex [Term] id: GO:0002198 name: S/G2 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931] comment: This term was made obsolete because it does not refer to a real biological process. is_obsolete: true [Term] id: GO:0002199 name: zona pellucida receptor complex namespace: cellular_component def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] synonym: "sperm protein complex I" RELATED [] is_a: GO:0043234 ! protein complex [Term] id: GO:0002200 name: somatic diversification of immune receptors namespace: biological_process def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002201 name: somatic diversification of DSCAM-based immune receptors namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174] comment: Note that this type of immune receptor may not be limited to insects. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002202 name: somatic diversification of variable lymphocyte receptors of jawless fish namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579] comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002203 name: proteolysis by cytosolic proteases associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody genes during immune response" RELATED [] synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002205 name: somatic hypermutation of immunoglobulin genes involved in immune response namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701] synonym: "somatic hypermutation of antibody genes during immune response" RELATED [] synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: part_of GO:0002344 ! B cell affinity maturation [Term] id: GO:0002206 name: gene conversion of immunoglobulin genes namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes" EXACT [] is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion is_a: GO:0016445 ! somatic diversification of immunoglobulins is_a: GO:0035822 ! gene conversion [Term] id: GO:0002207 name: gene conversion of immunoglobulin genes involved in immune response namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes during immune response" RELATED [] synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002206 ! gene conversion of immunoglobulin genes is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] synonym: "somatic diversification of antibodies during immune response" RELATED [] synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002209 name: behavioral defense response namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural defense response" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0007610 ! behavior [Term] id: GO:0002210 name: behavioral response to wounding namespace: biological_process def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural response to wounding" EXACT [] is_a: GO:0009611 ! response to wounding is_a: GO:0044708 ! single-organism behavior [Term] id: GO:0002211 name: behavioral defense response to insect namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "behavioural defense response to insect" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002213 ! defense response to insect is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002212 name: behavioral defense response to nematode namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] synonym: "behavioural defense response to nematode" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002215 ! defense response to nematode is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002213 name: defense response to insect namespace: biological_process alt_id: GO:0002214 def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009625 ! response to insect [Term] id: GO:0002215 name: defense response to nematode namespace: biological_process alt_id: GO:0002216 def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] synonym: "physiological defense response to nematode" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009624 ! response to nematode [Term] id: GO:0002218 name: activation of innate immune response namespace: biological_process alt_id: GO:0002219 def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] comment: This term was added by GO_REF:0000022. xref: Reactome:REACT_75835 "RLR (RIG-like receptor) mediated induction of IFN alpha/beta, Gallus gallus" is_a: GO:0002253 ! activation of immune response is_a: GO:0045089 ! positive regulation of innate immune response [Term] id: GO:0002220 name: innate immune response activating cell surface receptor signaling pathway namespace: biological_process def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002221 name: pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002222 name: stimulatory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002223 name: stimulatory C-type lectin receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002224 name: toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. synonym: "TLR signaling pathway" EXACT [ISBN:0781735149] synonym: "toll-like receptor signalling pathway" EXACT [] xref: Reactome:REACT_25035 "Innate immune response mediated by toll like receptors, Gallus gallus" is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] synonym: "activation of antimicrobial peptide production" NARROW [] synonym: "antimicrobial peptide induction" EXACT [] synonym: "stimulation of antimicrobial peptide production" NARROW [] synonym: "up regulation of antimicrobial peptide production" EXACT [] synonym: "up-regulation of antimicrobial peptide production" EXACT [] synonym: "upregulation of antimicrobial peptide production" EXACT [] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production relationship: positively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity namespace: biological_process def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "NK cell mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002229 name: defense response to oomycetes namespace: biological_process def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] is_a: GO:0002239 ! response to oomycetes is_a: GO:0006952 ! defense response [Term] id: GO:0002230 name: positive regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "activation of antiviral response by host" NARROW [] synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of antiviral response by host" NARROW [] synonym: "up regulation of antiviral response by host" EXACT [] synonym: "up-regulation of antiviral response by host" EXACT [] synonym: "upregulation of antiviral response by host" EXACT [] is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0002231 name: detection of oomycetes namespace: biological_process def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] is_a: GO:0002239 ! response to oomycetes is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002234 name: detection of endoplasmic reticulum overloading namespace: biological_process def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] synonym: "detection of ER overloading" EXACT [] is_a: GO:0006983 ! ER overload response is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002235 name: detection of unfolded protein namespace: biological_process def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0002236 name: detection of misfolded protein namespace: biological_process def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051788 ! response to misfolded protein [Term] id: GO:0002237 name: response to molecule of bacterial origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] synonym: "response to bacteria associated molecule" EXACT [] synonym: "response to bacterial associated molecule" EXACT [] synonym: "response to bacterium associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0009617 ! response to bacterium [Term] id: GO:0002238 name: response to molecule of fungal origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm] synonym: "response to fungus associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0009620 ! response to fungus [Term] id: GO:0002239 name: response to oomycetes namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] is_a: GO:0051707 ! response to other organism [Term] id: GO:0002240 name: response to molecule of oomycetes origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] synonym: "response to oomycetes associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0002239 ! response to oomycetes [Term] id: GO:0002241 name: response to parasitic plant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0002242 name: defense response to parasitic plant namespace: biological_process def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0006952 ! defense response [Term] id: GO:0002243 name: detection of parasitic plant namespace: biological_process def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0009602 ! detection of symbiont [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002247 name: clearance of damaged tissue involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002248 name: connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph] synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002249 name: lymphocyte anergy namespace: biological_process def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "acquired immune response" EXACT [ISBN:068340007X] xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process [Term] id: GO:0002253 name: activation of immune response namespace: biological_process def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002254 name: kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002526 ! acute inflammatory response is_a: GO:0072376 ! protein activation cascade [Term] id: GO:0002255 name: tissue kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] synonym: "glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002256 name: regulation of kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0002254 ! kinin cascade [Term] id: GO:0002257 name: negative regulation of kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "down regulation of kinin cascade" EXACT [] synonym: "down-regulation of kinin cascade" EXACT [] synonym: "downregulation of kinin cascade" EXACT [] synonym: "inhibition of kinin cascade" NARROW [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:2000258 ! negative regulation of protein activation cascade relationship: negatively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002258 name: positive regulation of kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "activation of kinin cascade" NARROW [] synonym: "stimulation of kinin cascade" NARROW [] synonym: "up regulation of kinin cascade" EXACT [] synonym: "up-regulation of kinin cascade" EXACT [] synonym: "upregulation of kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:2000259 ! positive regulation of protein activation cascade relationship: positively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002259 name: endothelial cell activation within high endothelial venule involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb] is_a: GO:0002264 ! endothelial cell activation involved in immune response [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis [Term] id: GO:0002261 name: mucosal lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation [Term] id: GO:0002266 name: follicular dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] is_a: GO:0001775 ! cell activation [Term] id: GO:0002267 name: follicular dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0002266 ! follicular dendritic cell activation [Term] id: GO:0002268 name: follicular dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002270 name: plasmacytoid dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002271 name: plasmacytoid dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002272 name: plasmacytoid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation [Term] id: GO:0002273 name: plasmacytoid dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002521 ! leukocyte differentiation [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002276 name: basophil activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "basophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045575 ! basophil activation [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response [Term] id: GO:0002278 name: eosinophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "eosinophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0043307 ! eosinophil activation [Term] id: GO:0002279 name: mast cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045576 ! mast cell activation [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "macrophage activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042116 ! macrophage activation [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response [Term] id: GO:0002283 name: neutrophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "neutrophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042119 ! neutrophil activation [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] synonym: "alpha-beta T-cell activation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0002288 name: NK T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte activation during immune response" RELATED [] synonym: "natural killer T-cell activation during immune response" RELATED [] synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] synonym: "NK T cell activation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte activation during immune response" RELATED [] synonym: "NK T-cell activation during immune response" RELATED [] synonym: "NK T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0002289 name: NK T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] synonym: "natural killer T-cell proliferation during immune response" RELATED [] synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte proliferation during immune response" RELATED [] synonym: "NK T-cell proliferation during immune response" RELATED [] synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0001866 ! NK T cell proliferation is_a: GO:0002288 ! NK T cell activation involved in immune response is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] synonym: "gamma-delta T-cell activation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0002291 name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development involved in immune response" RELATED [GOC:add] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0002293 name: alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002294 name: CD4-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002295 name: T-helper cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149] synonym: "T-helper cell fate commitment" EXACT [] synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149] synonym: "Thp lineage commitment" RELATED [ISBN:0781735149] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042093 ! T-helper cell differentiation [Term] id: GO:0002296 name: T-helper 1 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149] synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149] synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149] synonym: "Th1 fate commitment" EXACT [ISBN:0781735149] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0002297 name: T-helper 2 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149] synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149] synonym: "Th2 fate commitment" EXACT [ISBN:0781735149] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0002298 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002299 name: alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002300 name: CD8-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002301 name: CD4-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002302 name: CD8-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add] synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002304 name: gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002305 name: CD8-positive, gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002306 name: CD4-positive gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002307 name: CD8-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002308 name: CD8-positive, alpha-beta cytotoxic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0002310 name: alpha-beta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0002311 name: gamma-delta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0002312 name: B cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] synonym: "B cell activation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte activation during immune response" RELATED [] synonym: "B-cell activation during immune response" RELATED [] synonym: "B-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B cell development involved in immune response" RELATED [GOC:add] synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] synonym: "mature B lymphocyte differentiation during immune response" RELATED [] synonym: "mature B-cell differentiation during immune response" RELATED [] synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0002314 name: germinal center B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "germinal center B cell development" RELATED [GOC:add] synonym: "germinal center B lymphocyte differentiation" EXACT [] synonym: "germinal center B-cell differentiation" EXACT [] synonym: "germinal center B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002315 name: marginal zone B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "marginal zone B cell development" RELATED [GOC:add] synonym: "marginal zone B lymphocyte differentiation" EXACT [] synonym: "marginal zone B-cell differentiation" EXACT [] synonym: "marginal zone B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002316 name: follicular B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "follicular B cell development" RELATED [GOC:add] synonym: "follicular B lymphocyte differentiation" EXACT [] synonym: "follicular B-cell differentiation" EXACT [] synonym: "follicular B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002317 name: plasma cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "plasma cell development" RELATED [GOC:add] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation [Term] id: GO:0002319 name: memory B cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory B cell development" RELATED [GOC:add] synonym: "memory B lymphocyte differentiation" EXACT [] synonym: "memory B-cell differentiation" EXACT [] synonym: "memory B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation [Term] id: GO:0002321 name: natural killer cell progenitor differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002322 name: B cell proliferation involved in immune response namespace: biological_process def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] synonym: "B cell proliferation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte proliferation during immune response" RELATED [] synonym: "B-cell proliferation during immune response" RELATED [] synonym: "B-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0002324 name: natural killer cell proliferation involved in immune response namespace: biological_process def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK cell proliferation during immune response" RELATED [] is_a: GO:0001787 ! natural killer cell proliferation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002325 name: natural killer cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "NK cell differentiation during immune response" RELATED [] is_a: GO:0001779 ! natural killer cell differentiation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002326 name: B cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149] synonym: "B lymphocyte lineage commitment" EXACT [] synonym: "B-cell lineage commitment" EXACT [] synonym: "B-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002327 name: immature B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "immature B cell development" RELATED [GOC:add] synonym: "immature B lymphocyte differentiation" EXACT [] synonym: "immature B-cell differentiation" EXACT [] synonym: "immature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002328 name: pro-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149] synonym: "pro-B cell development" RELATED [GOC:add] synonym: "pro-B lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002329 name: pre-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "pre-B cell development" RELATED [GOC:add] synonym: "pre-B lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002330 name: pre-B cell receptor expression namespace: biological_process def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:jal, ISBN:0781735149] is_a: GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002331 name: pre-B cell allelic exclusion namespace: biological_process def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:jal, ISBN:0781735149] synonym: "pre-B lymphocyte allelic exclusion" EXACT [] is_a: GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002332 name: transitional stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "transitional stage B cell development" RELATED [GOC:add] synonym: "transitional stage B lymphocyte differentiation" EXACT [] synonym: "transitional stage B-cell differentiation" EXACT [] synonym: "transitional stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002333 name: transitional one stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T1 stage B cell differentiation" EXACT [] synonym: "transitional one stage B cell development" RELATED [GOC:add] synonym: "transitional one stage B lymphocyte differentiation" EXACT [] synonym: "transitional one stage B-cell differentiation" EXACT [] synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002334 name: transitional two stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T2 stage B cell differentiation" EXACT [] synonym: "transitional two stage B cell development" RELATED [GOC:add] synonym: "transitional two stage B lymphocyte differentiation" EXACT [] synonym: "transitional two stage B-cell differentiation" EXACT [] synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002335 name: mature B cell differentiation namespace: biological_process def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B lymphocyte differentiation" EXACT [] synonym: "mature B-cell differentiation" EXACT [] synonym: "mature B-lymphocyte differentiation" EXACT [] synonym: "mature cell development" RELATED [GOC:add] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002336 name: B-1 B cell lineage commitment namespace: biological_process def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149] synonym: "B-1 B lymphocyte lineage commitment" EXACT [] synonym: "B-1 B-cell lineage commitment" EXACT [] synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] is_a: GO:0002326 ! B cell lineage commitment relationship: part_of GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002337 name: B-1a B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1a B cell development" RELATED [GOC:add] synonym: "B-1a B lymphocyte differentiation" EXACT [] synonym: "B-1a B-cell differentiation" EXACT [] synonym: "B-1a B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002338 name: B-1b B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1b B cell development" RELATED [GOC:add] synonym: "B-1b B lymphocyte differentiation" EXACT [] synonym: "B-1b B-cell differentiation" EXACT [] synonym: "B-1b B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002339 name: B cell selection namespace: biological_process def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] synonym: "B lymphocyte selection" EXACT [] synonym: "B-cell selection" EXACT [] synonym: "B-lymphocyte selection" EXACT [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002340 name: central B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] synonym: "central B lymphocyte selection" EXACT [] synonym: "central B-cell selection" EXACT [] synonym: "central B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002341 name: central B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte anergy" EXACT [] synonym: "central B-cell anergy" EXACT [] synonym: "central B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002342 name: central B cell deletion namespace: biological_process def: "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis] synonym: "central B lymphocyte deletion" EXACT [] synonym: "central B-cell deletion" EXACT [] synonym: "central B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002343 name: peripheral B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte selection" EXACT [] synonym: "peripheral B-cell selection" EXACT [] synonym: "peripheral B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation namespace: biological_process def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "B lymphocyte affinity maturation" EXACT [] synonym: "B-cell affinity maturation" EXACT [] synonym: "B-lymphocyte affinity maturation" EXACT [] is_a: GO:0002343 ! peripheral B cell selection relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002345 name: peripheral B cell receptor editing namespace: biological_process def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] synonym: "peripheral B lymphocyte receptor editing" EXACT [] synonym: "peripheral B-cell receptor editing" EXACT [] synonym: "peripheral B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002346 name: B cell positive selection namespace: biological_process def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] synonym: "B lymphocyte positive selection" EXACT [] synonym: "B-cell positive selection" EXACT [] synonym: "B-lymphocyte positive selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002347 name: response to tumor cell namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0002348 name: central B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "central B lymphocyte positive selection" EXACT [] synonym: "central B-cell positive selection" EXACT [] synonym: "central B-lymphocyte positive selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002349 name: histamine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "histamine production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002350 name: peripheral B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "peripheral B lymphocyte positive selection" EXACT [] synonym: "peripheral B-cell positive selection" EXACT [] synonym: "peripheral B-lymphocyte positive selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002352 name: B cell negative selection namespace: biological_process def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] synonym: "B lymphocyte negative selection" EXACT [] synonym: "B-cell negative selection" EXACT [] synonym: "B-lymphocyte negative selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002353 name: plasma kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002354 name: central B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte negative selection" EXACT [] synonym: "central B-cell negative selection" EXACT [] synonym: "central B-lymphocyte negative selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002355 name: detection of tumor cell namespace: biological_process def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002356 name: peripheral B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte negative selection" EXACT [] synonym: "peripheral B-cell negative selection" EXACT [] synonym: "peripheral B-lymphocyte negative selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002357 name: defense response to tumor cell namespace: biological_process def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006952 ! defense response [Term] id: GO:0002358 name: B cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] synonym: "B lymphocyte homeostatic proliferation" EXACT [] synonym: "B-cell homeostatic proliferation" EXACT [] synonym: "B-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002359 name: B-1 B cell proliferation namespace: biological_process def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] synonym: "B-1 B lymphocyte proliferation" EXACT [] synonym: "B-1 B-cell proliferation" EXACT [] synonym: "B-1 B-lymphocyte proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002360 name: T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte lineage commitment" EXACT [] synonym: "T-cell lineage commitment" EXACT [] synonym: "T-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002361 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002362 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002363 name: alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "alpha-beta T-cell lineage commitment" EXACT [] synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002364 name: NK T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149] synonym: "natural killer T lymphocyte lineage commitment" EXACT [] synonym: "natural killer T-cell lineage commitment" EXACT [] synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] synonym: "NK T lymphocyte lineage commitment" EXACT [] synonym: "NK T-cell lineage commitment" EXACT [] synonym: "NK T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0001865 ! NK T cell differentiation [Term] id: GO:0002365 name: gamma-delta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149] synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] synonym: "gamma-delta T-cell lineage commitment" EXACT [] synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. synonym: "cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002368 name: B cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149] synonym: "B lymphocyte cytokine production" EXACT [] synonym: "B-cell cytokine production" EXACT [] synonym: "B-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002370 name: natural killer cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149] synonym: "NK cell cytokine production" EXACT [] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0002373 name: plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002374 name: cytokine secretion involved in immune response namespace: biological_process def: "The regulated release of cytokines from a cell that contributes to an immune response." [GOC:add, ISBN:0781735149] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002375 name: cytokine biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149] synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process [Term] id: GO:0002377 name: immunoglobulin production namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "antibody production" EXACT [] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002378 name: immunoglobulin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149] synonym: "antibody biosynthesis" EXACT [] synonym: "antibody biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0002379 name: immunoglobulin biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "antibody biosynthesis during immune response" RELATED [] synonym: "antibody biosynthetic process during immune response" RELATED [] synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002378 ! immunoglobulin biosynthetic process relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002380 name: immunoglobulin secretion involved in immune response namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:9185563] synonym: "antibody secretion during immune response" RELATED [] synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph] is_a: GO:0048305 ! immunoglobulin secretion relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin mediated immune response namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "antibody production during immune response" RELATED [] synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] is_a: GO:0002377 ! immunoglobulin production relationship: part_of GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002382 name: regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002383 name: immune response in brain or nervous system namespace: biological_process def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149] synonym: "immune response in MALT" EXACT [] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149] synonym: "immune response in GALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002388 name: immune response in Peyer's patch namespace: biological_process def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002389 name: tolerance induction in Peyer's patch namespace: biological_process def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149] is_a: GO:0002388 ! immune response in Peyer's patch is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue [Term] id: GO:0002390 name: platelet activating factor production namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] is_a: GO:0001816 ! cytokine production [Term] id: GO:0002391 name: platelet activating factor production involved in inflammatory response namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "platelet activating factor production involved in acute inflammatory response" BROAD [] is_a: GO:0002390 ! platelet activating factor production is_a: GO:0002534 ! cytokine production involved in inflammatory response [Term] id: GO:0002392 name: platelet activating factor secretion namespace: biological_process def: "The regulated release of platelet activating factor by a cell." [GOC:add, ISBN:0781735149] is_a: GO:0006812 ! cation transport is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015914 ! phospholipid transport is_a: GO:0050663 ! cytokine secretion [Term] id: GO:0002393 name: lysosomal enzyme production involved in inflammatory response namespace: biological_process def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002394 name: tolerance induction in gut-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149] synonym: "oral tolerance" RELATED [] synonym: "tolerance induction in GALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149] synonym: "immune response in NALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0002397 name: MHC class I protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002398 name: MHC class Ib protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002400 name: tolerance induction in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149] synonym: "nasal tolerance" RELATED [] synonym: "tolerance induction in NALT" EXACT [] is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002401 name: tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149] synonym: "tolerance induction in MALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002402 name: B cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149] synonym: "B cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002403 name: T cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002404 name: antigen sampling in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] synonym: "antigen sampling in MALT" EXACT [] synonym: "antigen transport in MALT" RELATED [] synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002405 name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] synonym: "antigen sampling by dendritic cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002406 name: antigen sampling by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] synonym: "antigen sampling by M cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002409 name: Langerhans cell chemotaxis namespace: biological_process def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] is_a: GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:0002410 name: plasmacytoid dendritic cell chemotaxis namespace: biological_process def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002411 name: T cell tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002413 ! tolerance induction to tumor cell is_a: GO:0002424 ! T cell mediated immune response to tumor cell is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002412 name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411] synonym: "antigen transcytosis by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] is_a: GO:0045056 ! transcytosis relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue [Term] id: GO:0002413 name: tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002414 name: immunoglobulin transcytosis in epithelial cells namespace: biological_process def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] is_a: GO:0045056 ! transcytosis [Term] id: GO:0002415 name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor namespace: biological_process def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] synonym: "antibody transcytosis mediated by pIgR" EXACT [] synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002416 name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor namespace: biological_process def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X] synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells [Term] id: GO:0002417 name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis [Term] id: GO:0002418 name: immune response to tumor cell namespace: biological_process def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006955 ! immune response [Term] id: GO:0002419 name: T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001913 ! T cell mediated cytotoxicity is_a: GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002420 name: natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell is_a: GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0002421 name: B cell antigen processing and presentation following pinocytosis namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002422 name: immune response in urogenital tract namespace: biological_process def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002423 name: natural killer cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002418 ! immune response to tumor cell [Term] id: GO:0002424 name: T cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002425 name: tolerance induction in urogenital tract namespace: biological_process def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] is_a: GO:0002422 ! immune response in urogenital tract is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002426 name: immunoglobulin production in mucosal tissue namespace: biological_process def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] synonym: "antibody production in mucosal tissue " EXACT [] is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002385 ! mucosal immune response [Term] id: GO:0002427 name: mucosal tolerance induction namespace: biological_process def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] is_a: GO:0002385 ! mucosal immune response is_a: GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002428 name: antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002429 name: immune response-activating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002757 ! immune response-activating signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002430 name: complement receptor mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "complement receptor mediated signalling pathway" EXACT [] synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002431 name: Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002432 name: granuloma formation namespace: biological_process def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process relationship: part_of GO:0002544 ! chronic inflammatory response [Term] id: GO:0002433 name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis namespace: biological_process def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah] synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT [GO_REF:0000022] is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0002434 name: immune complex clearance namespace: biological_process def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process [Term] id: GO:0002435 name: immune complex clearance by erythrocytes namespace: biological_process def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352] synonym: "immune complex clearance by RBCs" EXACT [CL:0000232] synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002436 name: immune complex clearance by monocytes and macrophages namespace: biological_process def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002437 name: inflammatory response to antigenic stimulus namespace: biological_process def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response is_a: GO:0006955 ! immune response [Term] id: GO:0002438 name: acute inflammatory response to antigenic stimulus namespace: biological_process def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002439 name: chronic inflammatory response to antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response namespace: biological_process def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "histamine secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0002349 ! histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002445 name: type II hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] xref: Wikipedia:Type_II_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002446 name: neutrophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002447 name: eosinophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002448 name: mast cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002450 name: B cell antigen processing and presentation namespace: biological_process def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation" EXACT [] synonym: "B-cell antigen processing and presentation" EXACT [] synonym: "B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0019724 ! B cell mediated immunity [Term] id: GO:0002451 name: peripheral B cell tolerance induction namespace: biological_process def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte tolerance induction" EXACT [] synonym: "peripheral B-cell tolerance induction" EXACT [] synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002514 ! B cell tolerance induction is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002452 name: B cell receptor editing namespace: biological_process def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte receptor editing" EXACT [] synonym: "B-cell receptor editing" EXACT [] synonym: "B-lymphocyte receptor editing" EXACT [] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002453 name: peripheral B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte anergy" EXACT [] synonym: "peripheral B-cell anergy" EXACT [] synonym: "peripheral B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002454 name: peripheral B cell deletion namespace: biological_process def: "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "peripheral B lymphocyte deletion" EXACT [] synonym: "peripheral B-cell deletion" EXACT [] synonym: "peripheral B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002455 name: humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "circulating antibody mediated immune response" EXACT [] synonym: "circulating immunoglobulin mediated immune response" EXACT [] synonym: "humoral defence mechanism" RELATED [] synonym: "humoral immune response mediated by circulating antibody" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0002456 ! T cell mediated immunity [Term] id: GO:0002458 name: peripheral T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149] synonym: "peripheral T lymphocyte tolerance induction" EXACT [] synonym: "peripheral T-cell tolerance induction" EXACT [] synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002459 name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579] synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] synonym: "adaptive immune response in jawless fish" EXACT [] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002461 name: tolerance induction dependent upon immune response namespace: biological_process def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "immune response-dependent tolerance induction" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002462 name: tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002463 name: central tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002508 ! central tolerance induction [Term] id: GO:0002464 name: peripheral tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002465 name: peripheral tolerance induction namespace: biological_process def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002466 name: peripheral tolerance induction to self antigen namespace: biological_process def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002467 name: germinal center formation namespace: biological_process def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002470 name: plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002473 name: non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] xref: Reactome:REACT_110097 "Class I MHC mediated antigen processing & presentation, Sus scrofa" xref: Reactome:REACT_114442 "Class I MHC mediated antigen processing & presentation, Xenopus tropicalis" xref: Reactome:REACT_75820 "Class I MHC mediated antigen processing & presentation, Homo sapiens" xref: Reactome:REACT_77569 "Class I MHC mediated antigen processing & presentation, Rattus norvegicus" xref: Reactome:REACT_83138 "Class I MHC mediated antigen processing & presentation, Bos taurus" xref: Reactome:REACT_84092 "Class I MHC mediated antigen processing & presentation, Taeniopygia guttata" xref: Reactome:REACT_86224 "Class I MHC mediated antigen processing & presentation, Mus musculus" xref: Reactome:REACT_88020 "Class I MHC mediated antigen processing & presentation, Danio rerio" xref: Reactome:REACT_90151 "Class I MHC mediated antigen processing & presentation, Canis familiaris" xref: Reactome:REACT_94042 "Class I MHC mediated antigen processing & presentation, Gallus gallus" is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002475 name: antigen processing and presentation via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002476 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0002477 name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "exogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002479 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] xref: Reactome:REACT_111056 "Cross-presentation of soluble exogenous antigens (endosomes), Homo sapiens" xref: Reactome:REACT_111174 "Cross-presentation of particulate exogenous antigens (phagosomes), Homo sapiens" xref: Reactome:REACT_111178 "ER-Phagosome pathway, Homo sapiens" is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002480 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] xref: Reactome:REACT_111168 "Endosomal/Vacuolar pathway, Homo sapiens" is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002481 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002482 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002483 name: antigen processing and presentation of endogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "endogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002484 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002485 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002486 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002487 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002488 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib [Term] id: GO:0002489 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002490 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002491 name: antigen processing and presentation of endogenous peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002492 name: peptide antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002493 name: lipid antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0065005 ! protein-lipid complex assembly relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002494 name: lipid antigen transport namespace: biological_process def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002496 name: proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002497 name: proteasomal proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0002498 name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002499 name: proteolysis within endosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002500 name: proteolysis within lysosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation is_a: GO:0007039 ! vacuolar protein catabolic process [Term] id: GO:0002501 name: peptide antigen assembly with MHC protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0002396 ! MHC protein complex assembly relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002502 name: peptide antigen assembly with MHC class I protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002397 ! MHC class I protein complex assembly relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002503 name: peptide antigen assembly with MHC class II protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002505 name: antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002506 name: polysaccharide assembly with MHC class II protein complex namespace: biological_process def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240] is_a: GO:0065006 ! protein-carbohydrate complex assembly relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002507 name: tolerance induction namespace: biological_process def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002508 name: central tolerance induction namespace: biological_process def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002509 name: central tolerance induction to self antigen namespace: biological_process def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002510 name: central B cell tolerance induction namespace: biological_process def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte tolerance induction" EXACT [] synonym: "central B-cell tolerance induction" EXACT [] synonym: "central B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002511 name: central B cell receptor editing namespace: biological_process def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte receptor editing" EXACT [] synonym: "central B-cell receptor editing" EXACT [] synonym: "central B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002512 name: central T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149] synonym: "central T lymphocyte tolerance induction" EXACT [] synonym: "central T-cell tolerance induction" EXACT [] synonym: "central T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002513 name: tolerance induction to self antigen namespace: biological_process def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002514 name: B cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922] synonym: "B lymphocyte tolerance induction" EXACT [] synonym: "B-cell tolerance induction" EXACT [] synonym: "B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy namespace: biological_process def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte anergy" EXACT [] synonym: "B-cell anergy" EXACT [] synonym: "B-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002516 name: B cell deletion namespace: biological_process def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149] synonym: "B lymphocyte deletion" EXACT [] synonym: "B-cell deletion" EXACT [] synonym: "B-lymphocyte deletion" EXACT [] is_a: GO:0001783 ! B cell apoptotic process relationship: part_of GO:0002514 ! B cell tolerance induction [Term] id: GO:0002517 name: T cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T lymphocyte tolerance induction" EXACT [] synonym: "T-cell tolerance induction" EXACT [] synonym: "T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002518 name: lymphocyte chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0002519 name: natural killer cell tolerance induction namespace: biological_process def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] synonym: "NK cell tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002524 name: hypersensitivity namespace: biological_process def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149] synonym: "hypersensitivity response" RELATED [ISBN:0781735149] xref: Wikipedia:Hypersensitivity is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002525 name: acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002527 name: vasodilation involved in acute inflammatory response namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal] synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002528 name: regulation of vascular permeability involved in acute inflammatory response namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0043114 ! regulation of vascular permeability relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002529 name: regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] is_a: GO:0002256 ! regulation of kinin cascade relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002530 name: regulation of systemic arterial blood pressure involved in acute-phase response namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] synonym: "blood pressure regulation during acute phase response" RELATED [] synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb] is_a: GO:0003073 ! regulation of systemic arterial blood pressure relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002531 name: regulation of heart contraction involved in acute-phase response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] synonym: "regulation of cardiac contraction during acute phase response" RELATED [] synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb] is_a: GO:0008016 ! regulation of heart contraction relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0044707 ! single-multicellular organism process relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002533 name: lysosomal enzyme secretion involved in inflammatory response namespace: biological_process def: "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514] synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah] synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0033299 ! secretion of lysosomal enzymes relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002535 name: platelet activating factor secretion involved in inflammatory response namespace: biological_process def: "The regulated release of platelet activating factor by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD [] is_a: GO:0002392 ! platelet activating factor secretion relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "oxidative burst during acute inflammatory response " BROAD [] synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] synonym: "respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response namespace: biological_process def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] synonym: "production of nitric oxide involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonic acid metabolite production involved in inflammatory response namespace: biological_process def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "leukotriene production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002541 name: activation of plasma proteins involved in acute inflammatory response namespace: biological_process def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149] is_a: GO:0016485 ! protein processing relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002542 name: Factor XII activation namespace: biological_process def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] synonym: "Hageman factor activation" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0010954 ! positive regulation of protein processing relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response [Term] id: GO:0002543 name: activation of blood coagulation via clotting cascade namespace: biological_process def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149] synonym: "activation of clotting cascade" EXACT [] is_a: GO:0030194 ! positive regulation of blood coagulation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response namespace: biological_process def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002545 name: chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002546 name: negative regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002547 name: positive regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002549 name: negative regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002550 name: positive regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002551 name: mast cell chemotaxis namespace: biological_process def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002552 name: serotonin secretion by mast cell namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] synonym: "serotonin release by mast cell" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002553 name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002554 name: serotonin secretion by platelet namespace: biological_process def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149] synonym: "serotonin release by platelet" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002555 name: histamine secretion by platelet namespace: biological_process def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002556 name: serotonin secretion by basophil namespace: biological_process def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149] synonym: "serotonin release by basophil" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002557 name: histamine secretion by basophil namespace: biological_process def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002558 name: type I hypersensitivity mediated by mast cells namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] is_a: GO:0002448 ! mast cell mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002559 name: type I hypersensitivity mediated by basophils namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] is_a: GO:0002560 ! basophil mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002560 name: basophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002561 name: basophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002276 ! basophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002560 ! basophil mediated immunity [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus namespace: biological_process def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002563 name: somatic diversification of immune receptors via alternate splicing namespace: biological_process def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002564 name: alternate splicing of immunoglobulin genes namespace: biological_process def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563] synonym: "alternate splicing of antibody genes" EXACT [] is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002565 name: somatic diversification of immune receptors via gene conversion namespace: biological_process def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation namespace: biological_process def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002567 name: somatic diversification of FREP-based immune receptors namespace: biological_process def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575] comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002568 name: somatic diversification of T cell receptor genes namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of TCR genes" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002569 name: somatic diversification of immune receptors by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002570 name: somatic diversification of immunoglobulin genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of antibody genes by N region addition" EXACT [] is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002571 name: somatic diversification of T cell receptor genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of TCR genes by N region addition" EXACT [] is_a: GO:0002568 ! somatic diversification of T cell receptor genes is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] synonym: "pro-T lymphocyte differentiation " EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002575 name: basophil chemotaxis namespace: biological_process def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002576 name: platelet degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] synonym: "platelet exocytosis" EXACT [] xref: Reactome:REACT_100828 "Platelet degranulation, Oryza sativa" xref: Reactome:REACT_102232 "Platelet degranulation, Mus musculus" xref: Reactome:REACT_102739 "Platelet degranulation, Rattus norvegicus" xref: Reactome:REACT_102744 "Platelet degranulation, Sus scrofa" xref: Reactome:REACT_104057 "Platelet degranulation, Saccharomyces cerevisiae" xref: Reactome:REACT_104856 "Platelet degranulation, Caenorhabditis elegans" xref: Reactome:REACT_118371 "Platelet degranulation, Escherichia coli" xref: Reactome:REACT_29845 "Platelet degranulation, Bos taurus" xref: Reactome:REACT_30497 "Platelet degranulation, Canis familiaris" xref: Reactome:REACT_31557 "Platelet degranulation, Gallus gallus" xref: Reactome:REACT_318 "Platelet degranulation, Homo sapiens" xref: Reactome:REACT_33703 "Platelet degranulation, Schizosaccharomyces pombe" xref: Reactome:REACT_80537 "Platelet degranulation, Drosophila melanogaster" xref: Reactome:REACT_81075 "Platelet degranulation, Xenopus tropicalis" xref: Reactome:REACT_81265 "Platelet degranulation, Danio rerio" xref: Reactome:REACT_81408 "Platelet degranulation, Arabidopsis thaliana" xref: Reactome:REACT_87179 "Platelet degranulation, Plasmodium falciparum" xref: Reactome:REACT_97581 "Platelet degranulation, Taeniopygia guttata" xref: Reactome:REACT_99712 "Platelet degranulation, Dictyostelium discoideum" is_a: GO:0006887 ! exocytosis [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process relationship: negatively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process relationship: positively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002583 name: regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002584 name: negative regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002585 name: positive regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002586 name: regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002587 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002588 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002589 name: regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002590 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002591 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002592 name: regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002593 name: negative regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002594 name: positive regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002595 name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002596 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002597 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002598 name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002599 name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002600 name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002601 name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002602 name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002603 name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002610 name: regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002611 name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002612 name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002619 name: regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002620 name: negative regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002621 name: positive regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002622 name: regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of B-cell antigen processing and presentation" EXACT [] synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002623 name: negative regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "down regulation of B cell antigen processing and presentation" EXACT [] synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] synonym: "downregulation of B cell antigen processing and presentation" EXACT [] synonym: "inhibition of B cell antigen processing and presentation" NARROW [] synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002624 name: positive regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "activation of B cell antigen processing and presentation" NARROW [] synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of B cell antigen processing and presentation" NARROW [] synonym: "up regulation of B cell antigen processing and presentation" EXACT [] synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] synonym: "upregulation of B cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002628 name: regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002629 name: negative regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0045861 ! negative regulation of proteolysis relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002630 name: positive regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0045862 ! positive regulation of proteolysis relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002631 name: regulation of granuloma formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002432 ! granuloma formation [Term] id: GO:0002632 name: negative regulation of granuloma formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "down regulation of granuloma formation" EXACT [] synonym: "down-regulation of granuloma formation" EXACT [] synonym: "downregulation of granuloma formation" EXACT [] synonym: "inhibition of granuloma formation" NARROW [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002698 ! negative regulation of immune effector process relationship: negatively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002633 name: positive regulation of granuloma formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "activation of granuloma formation" NARROW [] synonym: "stimulation of granuloma formation" NARROW [] synonym: "up regulation of granuloma formation" EXACT [] synonym: "up-regulation of granuloma formation" EXACT [] synonym: "upregulation of granuloma formation" EXACT [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002699 ! positive regulation of immune effector process relationship: positively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002634 name: regulation of germinal center formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002467 ! germinal center formation [Term] id: GO:0002635 name: negative regulation of germinal center formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "down regulation of germinal center formation" EXACT [] synonym: "down-regulation of germinal center formation" EXACT [] synonym: "downregulation of germinal center formation" EXACT [] synonym: "inhibition of germinal center formation" NARROW [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002636 name: positive regulation of germinal center formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "activation of germinal center formation" NARROW [] synonym: "stimulation of germinal center formation" NARROW [] synonym: "up regulation of germinal center formation" EXACT [] synonym: "up-regulation of germinal center formation" EXACT [] synonym: "upregulation of germinal center formation" EXACT [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002637 name: regulation of immunoglobulin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002638 name: negative regulation of immunoglobulin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "down regulation of immunoglobulin production" EXACT [] synonym: "down-regulation of immunoglobulin production" EXACT [] synonym: "downregulation of immunoglobulin production" EXACT [] synonym: "inhibition of immunoglobulin production" NARROW [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response relationship: negatively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002639 name: positive regulation of immunoglobulin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "activation of immunoglobulin production" NARROW [] synonym: "stimulation of immunoglobulin production" NARROW [] synonym: "up regulation of immunoglobulin production" EXACT [] synonym: "up-regulation of immunoglobulin production" EXACT [] synonym: "upregulation of immunoglobulin production" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response relationship: positively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002640 name: regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002641 name: negative regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "down regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "downregulation of immunoglobulin biosynthetic process" EXACT [] synonym: "inhibition of immunoglobulin biosynthetic process" NARROW [] is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002642 name: positive regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "activation of immunoglobulin biosynthetic process" NARROW [] synonym: "stimulation of immunoglobulin biosynthetic process" NARROW [] synonym: "up regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "upregulation of immunoglobulin biosynthetic process" EXACT [] is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002643 name: regulation of tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0002507 ! tolerance induction [Term] id: GO:0002644 name: negative regulation of tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "down regulation of tolerance induction" EXACT [] synonym: "down-regulation of tolerance induction" EXACT [] synonym: "downregulation of tolerance induction" EXACT [] synonym: "inhibition of tolerance induction" NARROW [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002683 ! negative regulation of immune system process relationship: negatively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002645 name: positive regulation of tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "activation of tolerance induction" NARROW [] synonym: "stimulation of tolerance induction" NARROW [] synonym: "up regulation of tolerance induction" EXACT [] synonym: "up-regulation of tolerance induction" EXACT [] synonym: "upregulation of tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process relationship: positively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002646 name: regulation of central tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002647 name: negative regulation of central tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "down regulation of central tolerance induction" EXACT [] synonym: "down-regulation of central tolerance induction" EXACT [] synonym: "downregulation of central tolerance induction" EXACT [] synonym: "inhibition of central tolerance induction" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction relationship: negatively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002648 name: positive regulation of central tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "activation of central tolerance induction" NARROW [] synonym: "stimulation of central tolerance induction" NARROW [] synonym: "up regulation of central tolerance induction" EXACT [] synonym: "up-regulation of central tolerance induction" EXACT [] synonym: "upregulation of central tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction relationship: positively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002649 name: regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002650 name: negative regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "down regulation of tolerance induction to self antigen" EXACT [] synonym: "down-regulation of tolerance induction to self antigen" EXACT [] synonym: "downregulation of tolerance induction to self antigen" EXACT [] synonym: "inhibition of tolerance induction to self antigen" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002651 name: positive regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "activation of tolerance induction to self antigen" NARROW [] synonym: "stimulation of tolerance induction to self antigen" NARROW [] synonym: "up regulation of tolerance induction to self antigen" EXACT [] synonym: "up-regulation of tolerance induction to self antigen" EXACT [] synonym: "upregulation of tolerance induction to self antigen" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002653 name: negative regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "activation of tolerance induction dependent upon immune response" NARROW [] synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002655 name: regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response relationship: regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002656 name: negative regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002657 name: positive regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "activation of tolerance induction to nonself antigen" NARROW [] synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002658 name: regulation of peripheral tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response relationship: regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002659 name: negative regulation of peripheral tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "down regulation of peripheral tolerance induction" EXACT [] synonym: "down-regulation of peripheral tolerance induction" EXACT [] synonym: "downregulation of peripheral tolerance induction" EXACT [] synonym: "inhibition of peripheral tolerance induction" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "activation of peripheral tolerance induction" NARROW [] synonym: "stimulation of peripheral tolerance induction" NARROW [] synonym: "up regulation of peripheral tolerance induction" EXACT [] synonym: "up-regulation of peripheral tolerance induction" EXACT [] synonym: "upregulation of peripheral tolerance induction" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction relationship: positively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002661 name: regulation of B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "regulation of B lymphocyte tolerance induction" EXACT [] synonym: "regulation of B-cell tolerance induction" EXACT [] synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002662 name: negative regulation of B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "down regulation of B cell tolerance induction" EXACT [] synonym: "down-regulation of B cell tolerance induction" EXACT [] synonym: "downregulation of B cell tolerance induction" EXACT [] synonym: "inhibition of B cell tolerance induction" NARROW [] synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of B-cell tolerance induction" EXACT [] synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: negatively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002663 name: positive regulation of B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "activation of B cell tolerance induction" NARROW [] synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of B-cell tolerance induction" EXACT [] synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of B cell tolerance induction" NARROW [] synonym: "up regulation of B cell tolerance induction" EXACT [] synonym: "up-regulation of B cell tolerance induction" EXACT [] synonym: "upregulation of B cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: positively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002664 name: regulation of T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "regulation of T lymphocyte tolerance induction" EXACT [] synonym: "regulation of T-cell tolerance induction" EXACT [] synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002665 name: negative regulation of T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "down regulation of T cell tolerance induction" EXACT [] synonym: "down-regulation of T cell tolerance induction" EXACT [] synonym: "downregulation of T cell tolerance induction" EXACT [] synonym: "inhibition of T cell tolerance induction" NARROW [] synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of T-cell tolerance induction" EXACT [] synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction relationship: negatively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002666 name: positive regulation of T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "activation of T cell tolerance induction" NARROW [] synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of T-cell tolerance induction" EXACT [] synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of T cell tolerance induction" NARROW [] synonym: "up regulation of T cell tolerance induction" EXACT [] synonym: "up-regulation of T cell tolerance induction" EXACT [] synonym: "upregulation of T cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction relationship: positively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002667 name: regulation of T cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "regulation of T lymphocyte anergy" EXACT [] synonym: "regulation of T-cell anergy" EXACT [] synonym: "regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: regulates GO:0002870 ! T cell anergy [Term] id: GO:0002668 name: negative regulation of T cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "down regulation of T cell anergy" EXACT [] synonym: "down-regulation of T cell anergy" EXACT [] synonym: "downregulation of T cell anergy" EXACT [] synonym: "inhibition of T cell anergy" NARROW [] synonym: "negative regulation of T lymphocyte anergy" EXACT [] synonym: "negative regulation of T-cell anergy" EXACT [] synonym: "negative regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy relationship: negatively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002669 name: positive regulation of T cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "activation of T cell anergy" NARROW [] synonym: "positive regulation of T lymphocyte anergy" EXACT [] synonym: "positive regulation of T-cell anergy" EXACT [] synonym: "positive regulation of T-lymphocyte anergy" EXACT [] synonym: "stimulation of T cell anergy" NARROW [] synonym: "up regulation of T cell anergy" EXACT [] synonym: "up-regulation of T cell anergy" EXACT [] synonym: "upregulation of T cell anergy" EXACT [] is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy relationship: positively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002670 name: regulation of B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "regulation of B lymphocyte anergy" EXACT [] synonym: "regulation of B-cell anergy" EXACT [] synonym: "regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: regulates GO:0002515 ! B cell anergy [Term] id: GO:0002671 name: negative regulation of B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "down regulation of B cell anergy" EXACT [] synonym: "down-regulation of B cell anergy" EXACT [] synonym: "downregulation of B cell anergy" EXACT [] synonym: "inhibition of B cell anergy" NARROW [] synonym: "negative regulation of B lymphocyte anergy" EXACT [] synonym: "negative regulation of B-cell anergy" EXACT [] synonym: "negative regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy relationship: negatively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002672 name: positive regulation of B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "activation of B cell anergy" NARROW [] synonym: "positive regulation of B lymphocyte anergy" EXACT [] synonym: "positive regulation of B-cell anergy" EXACT [] synonym: "positive regulation of B-lymphocyte anergy" EXACT [] synonym: "stimulation of B cell anergy" NARROW [] synonym: "up regulation of B cell anergy" EXACT [] synonym: "up-regulation of B cell anergy" EXACT [] synonym: "upregulation of B cell anergy" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy relationship: positively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response relationship: regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response relationship: negatively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response relationship: positively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002676 name: regulation of chronic inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response relationship: regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002677 name: negative regulation of chronic inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "down regulation of chronic inflammatory response" EXACT [] synonym: "down-regulation of chronic inflammatory response" EXACT [] synonym: "downregulation of chronic inflammatory response" EXACT [] synonym: "inhibition of chronic inflammatory response" NARROW [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response relationship: negatively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002678 name: positive regulation of chronic inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "activation of chronic inflammatory response" NARROW [] synonym: "stimulation of chronic inflammatory response" NARROW [] synonym: "up regulation of chronic inflammatory response" EXACT [] synonym: "up-regulation of chronic inflammatory response" EXACT [] synonym: "upregulation of chronic inflammatory response" EXACT [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response relationship: positively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002680 name: pro-T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149] synonym: "pro-T cell fate commitment" EXACT [] synonym: "pro-T lymphocyte fate commitment" EXACT [] synonym: "pro-T lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0002572 ! pro-T cell differentiation [Term] id: GO:0002681 name: somatic recombination of T cell receptor gene segments namespace: biological_process def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of TCR gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002568 ! somatic diversification of T cell receptor genes [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002691 name: regulation of cellular extravasation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration relationship: regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002692 name: negative regulation of cellular extravasation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "down regulation of cellular extravasation" EXACT [] synonym: "down-regulation of cellular extravasation" EXACT [] synonym: "downregulation of cellular extravasation" EXACT [] synonym: "inhibition of cellular extravasation" NARROW [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation relationship: negatively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002693 name: positive regulation of cellular extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "activation of cellular extravasation" NARROW [] synonym: "stimulation of cellular extravasation" NARROW [] synonym: "up regulation of cellular extravasation" EXACT [] synonym: "up-regulation of cellular extravasation" EXACT [] synonym: "upregulation of cellular extravasation" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation relationship: positively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation relationship: negatively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation relationship: positively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002715 name: regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045845 def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "regulation of natural killer cell activity" RELATED [] synonym: "regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002716 name: negative regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0030102 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "down regulation of natural killer cell mediated immunity" EXACT [] synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] synonym: "downregulation of natural killer cell mediated immunity" EXACT [] synonym: "inhibition of natural killer cell mediated immunity" NARROW [] synonym: "negative regulation of natural killer cell activity" RELATED [] synonym: "negative regulation of NK cell activity" RELATED [] synonym: "negative regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002717 name: positive regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045846 def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "activation of natural killer cell mediated immunity" NARROW [] synonym: "positive regulation of natural killer cell activity" RELATED [] synonym: "positive regulation of NK cell activity" RELATED [] synonym: "positive regulation of NK cell mediated immunity" EXACT [] synonym: "stimulation of natural killer cell mediated immunity" NARROW [] synonym: "up regulation of natural killer cell mediated immunity" EXACT [] synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] synonym: "upregulation of natural killer cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045089 ! positive regulation of innate immune response relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002721 name: regulation of B cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "regulation of B lymphocyte cytokine production" EXACT [] synonym: "regulation of B-cell cytokine production" EXACT [] synonym: "regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002722 name: negative regulation of B cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "down regulation of B cell cytokine production" EXACT [] synonym: "down-regulation of B cell cytokine production" EXACT [] synonym: "downregulation of B cell cytokine production" EXACT [] synonym: "inhibition of B cell cytokine production" NARROW [] synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] synonym: "negative regulation of B-cell cytokine production" EXACT [] synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production relationship: negatively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002723 name: positive regulation of B cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "activation of B cell cytokine production" NARROW [] synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] synonym: "positive regulation of B-cell cytokine production" EXACT [] synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] synonym: "stimulation of B cell cytokine production" NARROW [] synonym: "up regulation of B cell cytokine production" EXACT [] synonym: "up-regulation of B cell cytokine production" EXACT [] synonym: "upregulation of B cell cytokine production" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production relationship: positively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production relationship: negatively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production relationship: positively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002727 name: regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "regulation of NK cell cytokine production" EXACT [] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002728 name: negative regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "down regulation of natural killer cell cytokine production" EXACT [] synonym: "down-regulation of natural killer cell cytokine production" EXACT [] synonym: "downregulation of natural killer cell cytokine production" EXACT [] synonym: "inhibition of natural killer cell cytokine production" NARROW [] synonym: "negative regulation of NK cell cytokine production" EXACT [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002729 name: positive regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "activation of natural killer cell cytokine production" NARROW [] synonym: "positive regulation of NK cell cytokine production" EXACT [] synonym: "stimulation of natural killer cell cytokine production" NARROW [] synonym: "up regulation of natural killer cell cytokine production" EXACT [] synonym: "up-regulation of natural killer cell cytokine production" EXACT [] synonym: "upregulation of natural killer cell cytokine production" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002736 name: regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002737 name: negative regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002738 name: positive regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002739 name: regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002740 name: negative regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine secretion during immune response" RELATED [] synonym: "down-regulation of cytokine secretion during immune response" RELATED [] synonym: "downregulation of cytokine secretion during immune response" RELATED [] synonym: "inhibition of cytokine secretion during immune response" NARROW [] synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050710 ! negative regulation of cytokine secretion relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002741 name: positive regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "activation of cytokine secretion during immune response" NARROW [] synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine secretion during immune response" NARROW [] synonym: "up regulation of cytokine secretion during immune response" RELATED [] synonym: "up-regulation of cytokine secretion during immune response" RELATED [] synonym: "upregulation of cytokine secretion during immune response" RELATED [] is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050715 ! positive regulation of cytokine secretion relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002742 name: regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002743 name: negative regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002744 name: positive regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED [] is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002745 name: antigen processing and presentation initiated by receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002746 name: antigen processing and presentation following pinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002747 name: antigen processing and presentation following phagocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002748 name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149] synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002749 name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122] synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] is_a: GO:0002747 ! antigen processing and presentation following phagocytosis is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen [Term] id: GO:0002750 name: antigen processing and presentation following macropinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002751 name: antigen processing and presentation following receptor mediated endocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002752 name: cell surface pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "cell surface PAMP receptor signaling pathway" EXACT [] synonym: "cell surface pathogen receptor signaling pathway" EXACT [] synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] synonym: "cell surface PRR signaling pathway" EXACT [] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002753 name: cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located in the cytoplasm. Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] synonym: "cytoplasmic PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0002754 name: intracellular vesicle pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT [] synonym: "intracellular vesicle PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0002755 name: MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-dependent TLR signaling pathway" EXACT [] synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] xref: Reactome:REACT_100168 "MyD88 cascade initiated on plasma membrane, Gallus gallus" xref: Reactome:REACT_101942 "MyD88:Mal cascade initiated on plasma membrane, Gallus gallus" xref: Reactome:REACT_104035 "MyD88 cascade initiated on plasma membrane, Arabidopsis thaliana" xref: Reactome:REACT_106952 "MyD88 cascade initiated on plasma membrane, Sus scrofa" xref: Reactome:REACT_107977 "MyD88:Mal cascade initiated on plasma membrane, Xenopus tropicalis" xref: Reactome:REACT_110031 "MyD88 cascade initiated on plasma membrane, Dictyostelium discoideum" xref: Reactome:REACT_25089 "MyD88:TIRAP-dependent cascade initiated on plasma membrane, Gallus gallus" xref: Reactome:REACT_27215 "MyD88 cascade initiated on plasma membrane, Homo sapiens" xref: Reactome:REACT_27254 "MyD88-dependent cascade initiated on endosome membrane, Gallus gallus" xref: Reactome:REACT_27259 "MyD88 cascade initiated on plasma membrane, Gallus gallus" xref: Reactome:REACT_28050 "MyD88:Mal cascade initiated on plasma membrane, Danio rerio" xref: Reactome:REACT_30270 "MyD88 cascade initiated on plasma membrane, Schizosaccharomyces pombe" xref: Reactome:REACT_32510 "MyD88:Mal cascade initiated on plasma membrane, Caenorhabditis elegans" xref: Reactome:REACT_34594 "MyD88:Mal cascade initiated on plasma membrane, Sus scrofa" xref: Reactome:REACT_6788 "MyD88:Mal cascade initiated on plasma membrane, Homo sapiens" xref: Reactome:REACT_79855 "MyD88:Mal cascade initiated on plasma membrane, Dictyostelium discoideum" xref: Reactome:REACT_80624 "MyD88:Mal cascade initiated on plasma membrane, Arabidopsis thaliana" xref: Reactome:REACT_80969 "MyD88:Mal cascade initiated on plasma membrane, Bos taurus" xref: Reactome:REACT_81173 "MyD88 cascade initiated on plasma membrane, Mus musculus" xref: Reactome:REACT_81183 "MyD88 cascade initiated on plasma membrane, Drosophila melanogaster" xref: Reactome:REACT_85347 "MyD88:Mal cascade initiated on plasma membrane, Saccharomyces cerevisiae" xref: Reactome:REACT_85793 "MyD88:Mal cascade initiated on plasma membrane, Taeniopygia guttata" xref: Reactome:REACT_88707 "MyD88 cascade initiated on plasma membrane, Xenopus tropicalis" xref: Reactome:REACT_88909 "MyD88 cascade initiated on plasma membrane, Caenorhabditis elegans" xref: Reactome:REACT_90702 "MyD88:Mal cascade initiated on plasma membrane, Mus musculus" xref: Reactome:REACT_92018 "MyD88:Mal cascade initiated on plasma membrane, Drosophila melanogaster" xref: Reactome:REACT_92143 "MyD88:Mal cascade initiated on plasma membrane, Canis familiaris" xref: Reactome:REACT_93524 "MyD88 cascade initiated on plasma membrane, Danio rerio" xref: Reactome:REACT_93873 "MyD88 cascade initiated on plasma membrane, Saccharomyces cerevisiae" xref: Reactome:REACT_95154 "MyD88 cascade initiated on plasma membrane, Bos taurus" xref: Reactome:REACT_95427 "MyD88 cascade initiated on plasma membrane, Rattus norvegicus" xref: Reactome:REACT_95678 "MyD88 cascade initiated on plasma membrane, Canis familiaris" xref: Reactome:REACT_96158 "MyD88:Mal cascade initiated on plasma membrane, Rattus norvegicus" xref: Reactome:REACT_96187 "MyD88 cascade initiated on plasma membrane, Taeniopygia guttata" xref: Reactome:REACT_96209 "MyD88 cascade initiated on plasma membrane, Oryza sativa" xref: Reactome:REACT_99530 "MyD88:Mal cascade initiated on plasma membrane, Oryza sativa" xref: Reactome:REACT_99838 "MyD88:Mal cascade initiated on plasma membrane, Schizosaccharomyces pombe" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002756 name: MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-independent TLR signaling pathway" EXACT [] synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] xref: Reactome:REACT_100200 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Gallus gallus" xref: Reactome:REACT_102299 "MyD88-independent cascade initiated on plasma membrane, Caenorhabditis elegans" xref: Reactome:REACT_102509 "TRAF6 Mediated Induction of proinflammatory cytokines, Dictyostelium discoideum" xref: Reactome:REACT_102886 "TRAF6 Mediated Induction of proinflammatory cytokines, Saccharomyces cerevisiae" xref: Reactome:REACT_104655 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Mus musculus" xref: Reactome:REACT_105840 "TRAF6 Mediated Induction of proinflammatory cytokines, Gallus gallus" xref: Reactome:REACT_105924 "TRAF6 Mediated Induction of proinflammatory cytokines, Mus musculus" xref: Reactome:REACT_106037 "TRAF6 Mediated Induction of proinflammatory cytokines, Canis familiaris" xref: Reactome:REACT_106039 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Mus musculus" xref: Reactome:REACT_106964 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Danio rerio" xref: Reactome:REACT_109458 "TRAF6 Mediated Induction of proinflammatory cytokines, Rattus norvegicus" xref: Reactome:REACT_110829 "MyD88-independent cascade initiated on plasma membrane, Canis familiaris" xref: Reactome:REACT_110980 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Danio rerio" xref: Reactome:REACT_114143 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Drosophila melanogaster" xref: Reactome:REACT_25148 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Homo sapiens" xref: Reactome:REACT_28259 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Xenopus tropicalis" xref: Reactome:REACT_28395 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Bos taurus" xref: Reactome:REACT_28410 "MyD88-independent cascade initiated on plasma membrane, Oryza sativa" xref: Reactome:REACT_28525 "MyD88-independent cascade initiated on plasma membrane, Schizosaccharomyces pombe" xref: Reactome:REACT_29826 "MyD88-independent cascade initiated on plasma membrane, Gallus gallus" xref: Reactome:REACT_30390 "TRAF6 Mediated Induction of proinflammatory cytokines, Arabidopsis thaliana" xref: Reactome:REACT_31920 "TRAF6 Mediated Induction of proinflammatory cytokines, Sus scrofa" xref: Reactome:REACT_32587 "MyD88-independent cascade initiated on plasma membrane, Mus musculus" xref: Reactome:REACT_32888 "MyD88-independent cascade initiated on plasma membrane, Sus scrofa" xref: Reactome:REACT_33115 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Taeniopygia guttata" xref: Reactome:REACT_33276 "MyD88-independent cascade initiated on plasma membrane, Danio rerio" xref: Reactome:REACT_33454 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Sus scrofa" xref: Reactome:REACT_33857 "TRAF6 Mediated Induction of proinflammatory cytokines, Oryza sativa" xref: Reactome:REACT_34578 "TRAF6 Mediated Induction of proinflammatory cytokines, Drosophila melanogaster" xref: Reactome:REACT_6782 "TRAF6 Mediated Induction of proinflammatory cytokines, Homo sapiens" xref: Reactome:REACT_6809 "MyD88-independent cascade initiated on plasma membrane, Homo sapiens" xref: Reactome:REACT_6898 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Homo sapiens" xref: Reactome:REACT_6976 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Homo sapiens" xref: Reactome:REACT_70758 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Gallus gallus" xref: Reactome:REACT_78892 "MyD88-independent cascade initiated on plasma membrane, Saccharomyces cerevisiae" xref: Reactome:REACT_79777 "TRAF6 Mediated Induction of proinflammatory cytokines, Caenorhabditis elegans" xref: Reactome:REACT_81045 "TRAF6 Mediated Induction of proinflammatory cytokines, Danio rerio" xref: Reactome:REACT_81308 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Bos taurus" xref: Reactome:REACT_81312 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Sus scrofa" xref: Reactome:REACT_82068 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Rattus norvegicus" xref: Reactome:REACT_83083 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Canis familiaris" xref: Reactome:REACT_85389 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Rattus norvegicus" xref: Reactome:REACT_85560 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Rattus norvegicus" xref: Reactome:REACT_85813 "MyD88-independent cascade initiated on plasma membrane, Arabidopsis thaliana" xref: Reactome:REACT_87120 "MyD88-independent cascade initiated on plasma membrane, Dictyostelium discoideum" xref: Reactome:REACT_88311 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Xenopus tropicalis" xref: Reactome:REACT_88396 "MyD88-independent cascade initiated on plasma membrane, Xenopus tropicalis" xref: Reactome:REACT_88627 "TRAF6 Mediated Induction of proinflammatory cytokines, Schizosaccharomyces pombe" xref: Reactome:REACT_89370 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Xenopus tropicalis" xref: Reactome:REACT_89942 "MyD88-independent cascade initiated on plasma membrane, Rattus norvegicus" xref: Reactome:REACT_90312 "TRAF6 Mediated Induction of proinflammatory cytokines, Bos taurus" xref: Reactome:REACT_91487 "TRAF6 Mediated Induction of proinflammatory cytokines, Xenopus tropicalis" xref: Reactome:REACT_91606 "MyD88-independent cascade initiated on plasma membrane, Taeniopygia guttata" xref: Reactome:REACT_92796 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Taeniopygia guttata" xref: Reactome:REACT_93657 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Canis familiaris" xref: Reactome:REACT_94894 "TRAF6 Mediated Induction of proinflammatory cytokines, Taeniopygia guttata" xref: Reactome:REACT_95971 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Taeniopygia guttata" xref: Reactome:REACT_96392 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Bos taurus" xref: Reactome:REACT_96482 "MyD88-independent cascade initiated on plasma membrane, Bos taurus" xref: Reactome:REACT_97209 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Gallus gallus" xref: Reactome:REACT_98583 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Sus scrofa" xref: Reactome:REACT_99022 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Danio rerio" xref: Reactome:REACT_99202 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Canis familiaris" xref: Reactome:REACT_99347 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Mus musculus" xref: Reactome:REACT_99643 "MyD88-independent cascade initiated on plasma membrane, Drosophila melanogaster" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002757 name: immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] is_a: GO:0002253 ! activation of immune response is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002758 name: innate immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002757 ! immune response-activating signal transduction [Term] id: GO:0002759 name: regulation of antimicrobial humoral response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002760 name: positive regulation of antimicrobial humoral response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] synonym: "activation of antimicrobial humoral response" NARROW [] synonym: "stimulation of antimicrobial humoral response" NARROW [] synonym: "up regulation of antimicrobial humoral response" EXACT [] synonym: "up-regulation of antimicrobial humoral response" EXACT [] synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0043902 ! positive regulation of multi-organism process relationship: positively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation relationship: regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002764 name: immune response-regulating signaling pathway namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002765 name: immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002766 name: innate immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571] is_a: GO:0002765 ! immune response-inhibiting signal transduction [Term] id: GO:0002767 name: immune response-inhibiting cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] is_a: GO:0002765 ! immune response-inhibiting signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002768 name: immune response-regulating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002764 ! immune response-regulating signaling pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0002769 name: natural killer cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory KIR signaling pathway" NARROW [] synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] synonym: "natural killer cell inhibitory signalling pathway" EXACT [] synonym: "NK cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002770 name: T cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] synonym: "T cell inhibitory signalling pathway" EXACT [] synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] synonym: "T-cell inhibitory signaling pathway" EXACT [] synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002771 name: inhibitory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] synonym: "KIR signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002772 name: inhibitory C-type lectin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002773 name: B cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] synonym: "B cell inhibitory signalling pathway" EXACT [] synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] synonym: "B-cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002774 name: Fc receptor mediated inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149] synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002775 name: antimicrobial peptide production namespace: biological_process def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002776 name: antimicrobial peptide secretion namespace: biological_process def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002790 ! peptide secretion relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002777 name: antimicrobial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0043043 ! peptide biosynthetic process relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002778 name: antibacterial peptide production namespace: biological_process def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019731 ! antibacterial humoral response [Term] id: GO:0002779 name: antibacterial peptide secretion namespace: biological_process def: "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002780 name: antibacterial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002781 name: antifungal peptide production namespace: biological_process def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019732 ! antifungal humoral response [Term] id: GO:0002782 name: antifungal peptide secretion namespace: biological_process def: "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002783 name: antifungal peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002784 name: regulation of antimicrobial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0002759 ! regulation of antimicrobial humoral response relationship: regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002785 name: negative regulation of antimicrobial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] synonym: "down regulation of antimicrobial peptide production" EXACT [] synonym: "down-regulation of antimicrobial peptide production" EXACT [] synonym: "downregulation of antimicrobial peptide production" EXACT [] synonym: "inhibition of antimicrobial peptide production" NARROW [] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002786 name: regulation of antibacterial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:1900424 ! regulation of defense response to bacterium relationship: regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002787 name: negative regulation of antibacterial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "down regulation of antibacterial peptide production" EXACT [] synonym: "down-regulation of antibacterial peptide production" EXACT [] synonym: "downregulation of antibacterial peptide production" EXACT [] synonym: "inhibition of antibacterial peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production relationship: negatively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002788 name: regulation of antifungal peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:1900150 ! regulation of defense response to fungus relationship: regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002789 name: negative regulation of antifungal peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "down regulation of antifungal peptide production" EXACT [] synonym: "down-regulation of antifungal peptide production" EXACT [] synonym: "downregulation of antifungal peptide production" EXACT [] synonym: "inhibition of antifungal peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production relationship: negatively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002794 name: regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0002791 ! regulation of peptide secretion relationship: regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002795 name: negative regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "down regulation of antimicrobial peptide secretion" EXACT [] synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] synonym: "downregulation of antimicrobial peptide secretion" EXACT [] synonym: "inhibition of antimicrobial peptide secretion" NARROW [] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002796 name: positive regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "activation of antimicrobial peptide secretion" NARROW [] synonym: "stimulation of antimicrobial peptide secretion" NARROW [] synonym: "up regulation of antimicrobial peptide secretion" EXACT [] synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] synonym: "upregulation of antimicrobial peptide secretion" EXACT [] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002797 name: regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002798 name: negative regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "down regulation of antibacterial peptide secretion" EXACT [] synonym: "down-regulation of antibacterial peptide secretion" EXACT [] synonym: "downregulation of antibacterial peptide secretion" EXACT [] synonym: "inhibition of antibacterial peptide secretion" NARROW [] is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002799 name: positive regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "activation of antibacterial peptide secretion" NARROW [] synonym: "stimulation of antibacterial peptide secretion" NARROW [] synonym: "up regulation of antibacterial peptide secretion" EXACT [] synonym: "up-regulation of antibacterial peptide secretion" EXACT [] synonym: "upregulation of antibacterial peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002800 name: regulation of antifungal peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002801 name: negative regulation of antifungal peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "down regulation of antifungal peptide secretion" EXACT [] synonym: "down-regulation of antifungal peptide secretion" EXACT [] synonym: "downregulation of antifungal peptide secretion" EXACT [] synonym: "inhibition of antifungal peptide secretion" NARROW [] is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002802 name: positive regulation of antifungal peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "activation of antifungal peptide secretion" NARROW [] synonym: "stimulation of antifungal peptide secretion" NARROW [] synonym: "up regulation of antifungal peptide secretion" EXACT [] synonym: "up-regulation of antifungal peptide secretion" EXACT [] synonym: "upregulation of antifungal peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion relationship: positively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002803 name: positive regulation of antibacterial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "activation of antibacterial peptide production" NARROW [] synonym: "stimulation of antibacterial peptide production" NARROW [] synonym: "up regulation of antibacterial peptide production" EXACT [] synonym: "up-regulation of antibacterial peptide production" EXACT [] synonym: "upregulation of antibacterial peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production relationship: positively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002804 name: positive regulation of antifungal peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "activation of antifungal peptide production" NARROW [] synonym: "stimulation of antifungal peptide production" NARROW [] synonym: "up regulation of antifungal peptide production" EXACT [] synonym: "up-regulation of antifungal peptide production" EXACT [] synonym: "upregulation of antifungal peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production relationship: positively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002805 name: regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002806 name: negative regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002807 name: positive regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002808 name: regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002809 name: negative regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002810 name: regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002811 name: negative regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002812 name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium [Term] id: GO:0002813 name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002814 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002815 name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium [Term] id: GO:0002816 name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002817 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002818 name: intracellular defense response namespace: biological_process def: "A physiological defense response which occurs intracellularly." [GOC:add] synonym: "intracellular defence response" EXACT [] is_a: GO:0006968 ! cellular defense response is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002826 name: negative regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "down regulation of T-helper 1 type immune response" EXACT [] synonym: "down-regulation of T-helper 1 type immune response" EXACT [] synonym: "downregulation of T-helper 1 type immune response" EXACT [] synonym: "inhibition of T-helper 1 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "activation of T-helper 1 type immune response" NARROW [] synonym: "stimulation of T-helper 1 type immune response" NARROW [] synonym: "up regulation of T-helper 1 type immune response" EXACT [] synonym: "up-regulation of T-helper 1 type immune response" EXACT [] synonym: "upregulation of T-helper 1 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002829 name: negative regulation of type 2 immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "down regulation of type 2 immune response" EXACT [] synonym: "down-regulation of type 2 immune response" EXACT [] synonym: "downregulation of type 2 immune response" EXACT [] synonym: "inhibition of type 2 immune response" NARROW [] synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "negative regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002830 name: positive regulation of type 2 immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "activation of type 2 immune response" NARROW [] synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "positive regulation of Th2 immune response" NARROW [GOC:add] synonym: "stimulation of type 2 immune response" NARROW [] synonym: "up regulation of type 2 immune response" EXACT [] synonym: "up-regulation of type 2 immune response" EXACT [] synonym: "upregulation of type 2 immune response" EXACT [] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002834 name: regulation of response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "regulation of response to tumour cell" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus relationship: regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002835 name: negative regulation of response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "down regulation of response to tumor cell" EXACT [] synonym: "down-regulation of response to tumor cell" EXACT [] synonym: "downregulation of response to tumor cell" EXACT [] synonym: "inhibition of response to tumor cell" NARROW [] synonym: "negative regulation of response to tumour cell" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell relationship: negatively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002836 name: positive regulation of response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "activation of response to tumor cell" NARROW [] synonym: "positive regulation of response to tumour cell" EXACT [] synonym: "stimulation of response to tumor cell" NARROW [] synonym: "up regulation of response to tumor cell" EXACT [] synonym: "up-regulation of response to tumor cell" EXACT [] synonym: "upregulation of response to tumor cell" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell relationship: positively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002837 name: regulation of immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "regulation of immune response to tumour cell" EXACT [] is_a: GO:0002834 ! regulation of response to tumor cell is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002838 name: negative regulation of immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "down regulation of immune response to tumor cell" EXACT [] synonym: "down-regulation of immune response to tumor cell" EXACT [] synonym: "downregulation of immune response to tumor cell" EXACT [] synonym: "inhibition of immune response to tumor cell" NARROW [] synonym: "negative regulation of immune response to tumour cell" EXACT [] is_a: GO:0002835 ! negative regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002839 name: positive regulation of immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "activation of immune response to tumor cell" NARROW [] synonym: "positive regulation of immune response to tumour cell" EXACT [] synonym: "stimulation of immune response to tumor cell" NARROW [] synonym: "up regulation of immune response to tumor cell" EXACT [] synonym: "up-regulation of immune response to tumor cell" EXACT [] synonym: "upregulation of immune response to tumor cell" EXACT [] is_a: GO:0002836 ! positive regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002840 name: regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002841 name: negative regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002842 name: positive regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002843 name: regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002844 name: negative regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] synonym: "downregulation of tolerance induction to tumor cell" EXACT [] synonym: "inhibition of tolerance induction to tumor cell" NARROW [] synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002845 name: positive regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "activation of tolerance induction to tumor cell" NARROW [] synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] synonym: "stimulation of tolerance induction to tumor cell" NARROW [] synonym: "up regulation of tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] synonym: "upregulation of tolerance induction to tumor cell" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002846 name: regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002847 name: negative regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002848 name: positive regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002849 name: regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002850 name: negative regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002851 name: positive regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "activation of peripheral T cell tolerance induction" NARROW [] synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002852 name: regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002853 name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002854 name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002855 name: regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002856 name: negative regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002857 name: positive regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002858 name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002859 name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002860 name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002861 name: regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002862 name: negative regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002863 name: positive regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002864 name: regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002865 name: negative regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002866 name: positive regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002867 name: regulation of B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "regulation of B lymphocyte deletion" EXACT [] synonym: "regulation of B-cell deletion" EXACT [] synonym: "regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002902 ! regulation of B cell apoptotic process relationship: regulates GO:0002516 ! B cell deletion [Term] id: GO:0002868 name: negative regulation of B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "down regulation of B cell deletion" EXACT [] synonym: "down-regulation of B cell deletion" EXACT [] synonym: "downregulation of B cell deletion" EXACT [] synonym: "inhibition of B cell deletion" NARROW [] synonym: "negative regulation of B lymphocyte deletion" EXACT [] synonym: "negative regulation of B-cell deletion" EXACT [] synonym: "negative regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002903 ! negative regulation of B cell apoptotic process relationship: negatively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002869 name: positive regulation of B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "activation of B cell deletion" NARROW [] synonym: "positive regulation of B lymphocyte deletion" EXACT [] synonym: "positive regulation of B-cell deletion" EXACT [] synonym: "positive regulation of B-lymphocyte deletion" EXACT [] synonym: "stimulation of B cell deletion" NARROW [] synonym: "up regulation of B cell deletion" EXACT [] synonym: "up-regulation of B cell deletion" EXACT [] synonym: "upregulation of B cell deletion" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002904 ! positive regulation of B cell apoptotic process relationship: positively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002870 name: T cell anergy namespace: biological_process def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte anergy" EXACT [] synonym: "T-cell anergy" EXACT [] synonym: "T-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002871 name: regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002872 name: negative regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "down regulation of natural killer cell tolerance induction" EXACT [] synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] synonym: "downregulation of natural killer cell tolerance induction" EXACT [] synonym: "inhibition of natural killer cell tolerance induction" NARROW [] synonym: "negative regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002873 name: positive regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "activation of natural killer cell tolerance induction" NARROW [] synonym: "positive regulation of NK cell tolerance induction" EXACT [] synonym: "stimulation of natural killer cell tolerance induction" NARROW [] synonym: "up regulation of natural killer cell tolerance induction" EXACT [] synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] synonym: "upregulation of natural killer cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002874 name: regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002875 name: negative regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002876 name: positive regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002877 name: regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002878 name: negative regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002879 name: positive regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002880 name: regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002881 name: negative regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002882 name: positive regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002883 name: regulation of hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002884 name: negative regulation of hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "down regulation of hypersensitivity" EXACT [] synonym: "down-regulation of hypersensitivity" EXACT [] synonym: "downregulation of hypersensitivity" EXACT [] synonym: "inhibition of hypersensitivity" NARROW [] is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity relationship: negatively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002885 name: positive regulation of hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "activation of hypersensitivity" NARROW [] synonym: "stimulation of hypersensitivity" NARROW [] synonym: "up regulation of hypersensitivity" EXACT [] synonym: "up-regulation of hypersensitivity" EXACT [] synonym: "upregulation of hypersensitivity" EXACT [] is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity relationship: positively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002892 name: regulation of type II hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002893 name: negative regulation of type II hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "down regulation of type II hypersensitivity" EXACT [] synonym: "down-regulation of type II hypersensitivity" EXACT [] synonym: "downregulation of type II hypersensitivity" EXACT [] synonym: "inhibition of type II hypersensitivity" NARROW [] is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: negatively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002894 name: positive regulation of type II hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "activation of type II hypersensitivity" NARROW [] synonym: "stimulation of type II hypersensitivity" NARROW [] synonym: "up regulation of type II hypersensitivity" EXACT [] synonym: "up-regulation of type II hypersensitivity" EXACT [] synonym: "upregulation of type II hypersensitivity" EXACT [] is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: positively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002895 name: regulation of central B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] is_a: GO:0002646 ! regulation of central tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002896 name: negative regulation of central B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "down regulation of central B cell tolerance induction" EXACT [] synonym: "down-regulation of central B cell tolerance induction" EXACT [] synonym: "downregulation of central B cell tolerance induction" EXACT [] synonym: "inhibition of central B cell tolerance induction" NARROW [] is_a: GO:0002647 ! negative regulation of central tolerance induction is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002897 name: positive regulation of central B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "activation of central B cell tolerance induction" NARROW [] synonym: "stimulation of central B cell tolerance induction" NARROW [] synonym: "up regulation of central B cell tolerance induction" EXACT [] synonym: "up-regulation of central B cell tolerance induction" EXACT [] synonym: "upregulation of central B cell tolerance induction" EXACT [] is_a: GO:0002648 ! positive regulation of central tolerance induction is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction relationship: positively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002898 name: regulation of central B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002899 name: negative regulation of central B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "down regulation of central B cell deletion" EXACT [] synonym: "down-regulation of central B cell deletion" EXACT [] synonym: "downregulation of central B cell deletion" EXACT [] synonym: "inhibition of central B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002898 ! regulation of central B cell deletion relationship: negatively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002900 name: positive regulation of central B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "activation of central B cell deletion" NARROW [] synonym: "stimulation of central B cell deletion" NARROW [] synonym: "up regulation of central B cell deletion" EXACT [] synonym: "up-regulation of central B cell deletion" EXACT [] synonym: "upregulation of central B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002898 ! regulation of central B cell deletion relationship: positively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002901 name: mature B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of mature B cells" EXACT [] synonym: "apoptosis of mature B lymphocytes" EXACT [] synonym: "apoptosis of mature B-cells" EXACT [] synonym: "apoptosis of mature B-lymphocytes" EXACT [] synonym: "mature B cell apoptosis" NARROW [] synonym: "mature B cell programmed cell death by apoptosis" EXACT [] synonym: "mature B lymphocyte apoptosis" EXACT [] synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "mature B-cell apoptosis" EXACT [] synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] synonym: "mature B-lymphocyte apoptosis" EXACT [] synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, mature B cells" EXACT [] synonym: "programmed cell death, mature B lymphocytes" EXACT [] synonym: "programmed cell death, mature B-cells" EXACT [] synonym: "programmed cell death, mature B-lymphocytes" EXACT [] is_a: GO:0001783 ! B cell apoptotic process relationship: part_of GO:0001782 ! B cell homeostasis [Term] id: GO:0002902 name: regulation of B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of B cell apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process relationship: regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002903 name: negative regulation of B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of B cell apoptosis" EXACT [] synonym: "down-regulation of B cell apoptosis" EXACT [] synonym: "downregulation of B cell apoptosis" EXACT [] synonym: "inhibition of B cell apoptosis" NARROW [] synonym: "negative regulation of B cell apoptosis" NARROW [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process relationship: negatively_regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002904 name: positive regulation of B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of B cell apoptosis" NARROW [] synonym: "positive regulation of B cell apoptosis" NARROW [] synonym: "stimulation of B cell apoptosis" NARROW [] synonym: "up regulation of B cell apoptosis" EXACT [] synonym: "up-regulation of B cell apoptosis" EXACT [] synonym: "upregulation of B cell apoptosis" EXACT [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process relationship: positively_regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002905 name: regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0032844 ! regulation of homeostatic process relationship: regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002906 name: negative regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mature B cell apoptosis" EXACT [] synonym: "down-regulation of mature B cell apoptosis" EXACT [] synonym: "downregulation of mature B cell apoptosis" EXACT [] synonym: "inhibition of mature B cell apoptosis" NARROW [] synonym: "negative regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002907 name: positive regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mature B cell apoptosis" NARROW [] synonym: "positive regulation of mature B cell apoptosis" NARROW [] synonym: "stimulation of mature B cell apoptosis" NARROW [] synonym: "up regulation of mature B cell apoptosis" EXACT [] synonym: "up-regulation of mature B cell apoptosis" EXACT [] synonym: "upregulation of mature B cell apoptosis" EXACT [] is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002908 name: regulation of peripheral B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002867 ! regulation of B cell deletion relationship: regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002909 name: negative regulation of peripheral B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "down regulation of peripheral B cell deletion" EXACT [] synonym: "down-regulation of peripheral B cell deletion" EXACT [] synonym: "downregulation of peripheral B cell deletion" EXACT [] synonym: "inhibition of peripheral B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002910 name: positive regulation of peripheral B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "activation of peripheral B cell deletion" NARROW [] synonym: "stimulation of peripheral B cell deletion" NARROW [] synonym: "up regulation of peripheral B cell deletion" EXACT [] synonym: "up-regulation of peripheral B cell deletion" EXACT [] synonym: "upregulation of peripheral B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion relationship: positively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002911 name: regulation of lymphocyte anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002912 name: negative regulation of lymphocyte anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "down regulation of lymphocyte anergy" EXACT [] synonym: "down-regulation of lymphocyte anergy" EXACT [] synonym: "downregulation of lymphocyte anergy" EXACT [] synonym: "inhibition of lymphocyte anergy" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: negatively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002913 name: positive regulation of lymphocyte anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "activation of lymphocyte anergy" NARROW [] synonym: "stimulation of lymphocyte anergy" NARROW [] synonym: "up regulation of lymphocyte anergy" EXACT [] synonym: "up-regulation of lymphocyte anergy" EXACT [] synonym: "upregulation of lymphocyte anergy" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: positively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002914 name: regulation of central B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002915 name: negative regulation of central B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "down regulation of central B cell anergy" EXACT [] synonym: "down-regulation of central B cell anergy" EXACT [] synonym: "downregulation of central B cell anergy" EXACT [] synonym: "inhibition of central B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002914 ! regulation of central B cell anergy relationship: negatively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002916 name: positive regulation of central B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "activation of central B cell anergy" NARROW [] synonym: "stimulation of central B cell anergy" NARROW [] synonym: "up regulation of central B cell anergy" EXACT [] synonym: "up-regulation of central B cell anergy" EXACT [] synonym: "upregulation of central B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002914 ! regulation of central B cell anergy relationship: positively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002917 name: regulation of peripheral B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002918 name: negative regulation of peripheral B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "down regulation of peripheral B cell anergy" EXACT [] synonym: "down-regulation of peripheral B cell anergy" EXACT [] synonym: "downregulation of peripheral B cell anergy" EXACT [] synonym: "inhibition of peripheral B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002917 ! regulation of peripheral B cell anergy relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002919 name: positive regulation of peripheral B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "activation of peripheral B cell anergy" NARROW [] synonym: "stimulation of peripheral B cell anergy" NARROW [] synonym: "up regulation of peripheral B cell anergy" EXACT [] synonym: "up-regulation of peripheral B cell anergy" EXACT [] synonym: "upregulation of peripheral B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002917 ! regulation of peripheral B cell anergy relationship: positively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002920 name: regulation of humoral immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0006959 ! humoral immune response [Term] id: GO:0002921 name: negative regulation of humoral immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "down regulation of humoral immune response" EXACT [] synonym: "down-regulation of humoral immune response" EXACT [] synonym: "downregulation of humoral immune response" EXACT [] synonym: "inhibition of humoral immune response" NARROW [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002922 name: positive regulation of humoral immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "activation of humoral immune response" NARROW [] synonym: "stimulation of humoral immune response" NARROW [] synonym: "up regulation of humoral immune response" EXACT [] synonym: "up-regulation of humoral immune response" EXACT [] synonym: "upregulation of humoral immune response" EXACT [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002923 name: regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0002920 ! regulation of humoral immune response relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002924 name: negative regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002925 name: positive regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002926 name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. namespace: biological_process def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988] synonym: "mcm5s2U34 biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification [Term] id: GO:0002927 name: archaeosine-tRNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, a an archaea-specific modified base found at position 15 in the in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393] comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine. is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002929 name: MECO complex namespace: cellular_component def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642] synonym: "meta-coactivator complex" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: GO:0002930 name: trabecular meshwork development namespace: biological_process def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002931 name: response to ischemia namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd] comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia . is_a: GO:0006950 ! response to stress [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0035989 ! tendon development [Term] id: GO:0002933 name: lipid hydroxylation namespace: biological_process def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937] synonym: "fatty acid hydroxylation" RELATED [] is_a: GO:0030258 ! lipid modification [Term] id: GO:0002934 name: desmosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0002935 name: tRNA (adenine-C2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA." [PMID:22891362] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0002936 name: bradykinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291] is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0002937 name: tRNA 4-thiouridine biosynthesis namespace: biological_process def: "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X] comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to he unidentified intermediate. NuvC also participate sin thiamine synthesis. is_a: GO:0034227 ! tRNA thio-modification [Term] id: GO:0002938 name: tRNA guanine ribose methylation namespace: biological_process def: "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:155581075X, ISBN:1555811337] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002939 name: tRNA N1-guanine methylation namespace: biological_process def: "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m1-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002940 name: tRNA N2-guanine methylation namespace: biological_process def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m2-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002941 name: synoviocyte proliferation namespace: biological_process def: "The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues." [CL:0000214, PMID:9546370] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0002942 name: tRNA m2,2-guanine biosynthesis namespace: biological_process def: "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:1-55581-073-x] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002943 name: tRNA dihydrouridine synthesis namespace: biological_process def: "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:1-55581-073-x] comment: Dihydrouridine is found in numerous positions within loop I, the so called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b. is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002944 name: cyclin K-CDK12 complex namespace: cellular_component def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] synonym: "CycK/Cdk12 complex" RELATED [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0002945 name: cyclin K-CDK13 complex namespace: cellular_component def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] synonym: "CycK/Cdk13 complex" RELATED [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0002946 name: tRNA C5-cytosine methylation namespace: biological_process def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:1-55581-073-x] synonym: "tRNA 5-methylcytosine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002947 name: tumor necrosis factor receptor superfamily complex namespace: cellular_component def: "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc] synonym: "TNF receptor superfamily complex" RELATED [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0003001 name: generation of a signal involved in cell-cell signaling namespace: biological_process def: "The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] synonym: "formation of a signal" BROAD [] synonym: "generation of a signal involved in cell-cell signalling" EXACT [] synonym: "signal generation" BROAD [] is_a: GO:0044763 ! single-organism cellular process relationship: part_of GO:0007267 ! cell-cell signaling [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003003 name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage namespace: biological_process def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0003004 name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048164 ! distinct antral spaces stage [Term] id: GO:0003005 name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048163 ! scattered antral spaces stage [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003010 name: voluntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003011 name: involuntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism." [GOC:cjm, GOC:mtg_cardio] synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "respiratory gaseous exchange by respiratory system" EXACT [] is_a: GO:0003008 ! system process is_a: GO:0007585 ! respiratory gaseous exchange [Term] id: GO:0003017 name: lymph circulation namespace: biological_process def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003018 name: vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003019 name: central nervous system control of baroreceptor feedback namespace: biological_process def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0003020 name: detection of reduced oxygen by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0070483 ! detection of hypoxia relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003021 name: detection of increased carbon dioxide by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003022 name: detection of pH by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003030 ! detection of hydrogen ion relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003023 name: baroreceptor detection of increased arterial stretch namespace: biological_process def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0003024 name: baroreceptor detection of decreased arterial stretch namespace: biological_process def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0003025 name: regulation of systemic arterial blood pressure by baroreceptor feedback namespace: biological_process def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003026 name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0003027 name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah] synonym: "vagal reflex" BROAD [] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003028 name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003029 name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003030 name: detection of hydrogen ion namespace: biological_process def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003031 name: detection of carbon dioxide namespace: biological_process def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003033 name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003034 name: detection of increased carbon dioxide by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003035 name: detection of increased carbon dioxide by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003036 name: detection of pH by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003037 name: detection of pH by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003038 name: detection of reduced oxygen by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003039 name: detection of reduced oxygen by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003040 name: excitation of vasomotor center by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003041 name: excitation of vasomotor center by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003042 name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951] synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003043 name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003045 name: regulation of systemic arterial blood pressure by physical factors namespace: biological_process def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by physical factors" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003046 name: regulation of systemic arterial blood pressure by stress relaxation namespace: biological_process def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by stress relaxation" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0003047 name: regulation of systemic arterial blood pressure by epinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by epinephrine" RELATED [] synonym: "regulation of blood pressure by adrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003048 name: regulation of systemic arterial blood pressure by norepinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by norepinephrine" RELATED [] synonym: "regulation of blood pressure by noradrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003049 name: regulation of systemic arterial blood pressure by capillary fluid shift namespace: biological_process def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by capillary fluid shift" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors [Term] id: GO:0003050 name: regulation of systemic arterial blood pressure by atrial natriuretic peptide namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003051 name: angiotensin-mediated drinking behavior namespace: biological_process def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] is_a: GO:0042756 ! drinking behavior relationship: part_of GO:0002035 ! brain renin-angiotensin system [Term] id: GO:0003052 name: circadian regulation of systemic arterial blood pressure namespace: biological_process def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003053 name: circadian regulation of heart rate namespace: biological_process def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate" RELATED [] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0007623 ! circadian rhythm is_a: GO:0044707 ! single-multicellular organism process [Term] id: GO:0003054 name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "master pacemaker clock regulation of blood pressure" EXACT [] synonym: "SCN regulation of blood pressure" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003055 name: circadian regulation of heart rate by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] synonym: "master pacemaker clock regulation of heart rate" EXACT [] synonym: "SCN regulation of heart rate" EXACT [] is_a: GO:0003053 ! circadian regulation of heart rate [Term] id: GO:0003056 name: regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0019229 ! regulation of vasoconstriction relationship: regulates GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0003057 name: regulation of the force of heart contraction by chemical signal namespace: biological_process def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] synonym: "chemical cardiac inotropy" EXACT [] synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0003058 name: hormonal regulation of the force of heart contraction namespace: biological_process def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac inotropy" EXACT [] synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal [Term] id: GO:0003059 name: positive regulation of the force of heart contraction by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac inotropy" EXACT [] synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac inotropy" EXACT [] synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003060 name: negative regulation of the force of heart contraction by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "decreased force of heart contraction by acetylcholine" EXACT [] is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003061 name: positive regulation of the force of heart contraction by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] synonym: "increased force of heart contraction by adrenaline" RELATED [] synonym: "increased force of heart contraction by norepinephrine" EXACT [] synonym: "noradrenaline cardiac inotropy" EXACT [] synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac inotropy" EXACT [] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003062 name: regulation of heart rate by chemical signal namespace: biological_process def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] synonym: "chemical cardiac chronotropy" EXACT [] synonym: "chemical signal regulation of heart contraction rate" RELATED [] synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate [Term] id: GO:0003063 name: negative regulation of heart rate by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003064 name: regulation of heart rate by hormone namespace: biological_process def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac chronotropy" EXACT [] synonym: "regulation of the rate of heart contraction by hormone" EXACT [GOC:curators] is_a: GO:0003062 ! regulation of heart rate by chemical signal [Term] id: GO:0003065 name: positive regulation of heart rate by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac chronotropy" EXACT [] synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003066 name: positive regulation of heart rate by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "noradrenaline cardiac chronotropy" EXACT [] synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003067 name: circadian regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003068 name: regulation of systemic arterial blood pressure by acetylcholine namespace: biological_process def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] synonym: "blood pressure regulation by acetylcholine" EXACT [] is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter [Term] id: GO:0003069 name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003070 name: regulation of systemic arterial blood pressure by neurotransmitter namespace: biological_process def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "renal control of blood pressure" EXACT [] synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0003014 ! renal system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003072 name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0003074 name: regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035809 [Term] id: GO:0003075 name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure [Term] id: GO:0003077 name: negative regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035811 [Term] id: GO:0003078 name: regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035813 [Term] id: GO:0003079 name: positive regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035815 [Term] id: GO:0003080 name: negative regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035814 [Term] id: GO:0003081 name: regulation of systemic arterial blood pressure by renin-angiotensin namespace: biological_process def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by renin-angiotensin" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003082 name: positive regulation of renal output by angiotensin namespace: biological_process def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0003083 name: negative regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002019 ! regulation of renal output by angiotensin is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0003084 name: positive regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045777 ! positive regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003085 name: negative regulation of systemic arterial blood pressure namespace: biological_process def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045776 ! negative regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003086 name: regulation of systemic arterial blood pressure by local renal renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0003087 name: positive regulation of the force of heart contraction by neuronal epinephrine namespace: biological_process def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine [Term] id: GO:0003088 name: positive regulation of the force of heart contraction by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine [Term] id: GO:0003089 name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003090 name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003091 name: renal water homeostasis namespace: biological_process def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] synonym: "water homeostasis by the kidney" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0003092 name: renal water retention namespace: biological_process def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio] synonym: "negative regulation of renal water excretion" EXACT [] is_a: GO:0035811 ! negative regulation of urine volume [Term] id: GO:0003093 name: regulation of glomerular filtration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003094 name: glomerular filtration namespace: biological_process def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949] is_a: GO:0097205 ! renal filtration [Term] id: GO:0003095 name: pressure natriuresis namespace: biological_process def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport [Term] id: GO:0003097 name: renal water transport namespace: biological_process def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006833 ! water transport relationship: part_of GO:0003091 ! renal water homeostasis [Term] id: GO:0003098 name: tubuloglomerular feedback namespace: biological_process def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] xref: Wikipedia:Tubuloglomerular_feedback is_a: GO:0001977 ! renal system process involved in regulation of blood volume relationship: part_of GO:0003093 ! regulation of glomerular filtration [Term] id: GO:0003099 name: positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0003100 name: regulation of systemic arterial blood pressure by endothelin namespace: biological_process def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003101 name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine namespace: biological_process def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003102 name: positive regulation of diuresis by angiotensin namespace: biological_process def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] is_obsolete: true consider: GO:0035810 [Term] id: GO:0003103 name: positive regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0035810 [Term] id: GO:0003104 name: positive regulation of glomerular filtration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003105 name: negative regulation of glomerular filtration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003106 name: negative regulation of glomerular filtration by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb] synonym: "regulation of glomerular filtration by angiotensin" BROAD [] is_a: GO:0003083 ! negative regulation of renal output by angiotensin relationship: part_of GO:0003105 ! negative regulation of glomerular filtration [Term] id: GO:0003107 name: positive regulation of natriuresis by angiotensin namespace: biological_process def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0003108 name: negative regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0003109 name: positive regulation of the force of heart contraction by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003110 name: positive regulation of the force of heart contraction by neuronal norepinephrine namespace: biological_process def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003111 name: positive regulation of heart rate by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003112 name: positive regulation of heart rate by neuronal epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003113 name: positive regulation of heart rate by neuronal norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003114 name: positive regulation of heart rate by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003115 name: regulation of vasoconstriction by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003116 name: regulation of vasoconstriction by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003117 name: regulation of vasoconstriction by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003118 name: regulation of vasoconstriction by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003119 name: regulation of vasoconstriction by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003120 name: regulation of vasoconstriction by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003121 name: regulation of vasodilation by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by adrenaline" EXACT [] is_a: GO:0042312 ! regulation of vasodilation [Term] id: GO:0003122 name: regulation of vasodilation by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by noradrenaline" EXACT [] is_a: GO:0042312 ! regulation of vasodilation [Term] id: GO:0003123 name: regulation of vasodilation by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating adrenaline" EXACT [] is_a: GO:0003121 ! regulation of vasodilation by epinephrine [Term] id: GO:0003124 name: regulation of vasodilation by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by neuronal adrenaline" EXACT [] is_a: GO:0003121 ! regulation of vasodilation by epinephrine [Term] id: GO:0003125 name: regulation of vasodilation by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating noradrenaline" EXACT [] is_a: GO:0003122 ! regulation of vasodilation by norepinephrine [Term] id: GO:0003126 name: regulation of vasodilation by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT [] is_a: GO:0003122 ! regulation of vasodilation by norepinephrine [Term] id: GO:0003127 name: detection of nodal flow namespace: biological_process def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0003128 name: heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart] is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003129 name: heart induction namespace: biological_process def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart] is_a: GO:0001759 ! organ induction is_a: GO:2000826 ! regulation of heart morphogenesis relationship: positively_regulates GO:0003128 ! heart field specification [Term] id: GO:0003130 name: BMP signaling pathway involved in heart induction namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0003132 name: mesodermal-endodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003131 ! mesodermal-endodermal cell signaling is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0003134 name: endodermal-mesodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003133 ! endodermal-mesodermal cell signaling is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003135 name: fibroblast growth factor receptor signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003136 name: negative regulation of heart induction by canonical Wnt receptor signaling pathway namespace: biological_process def: "Any canonical Wnt receptor signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development is_a: GO:1901320 ! negative regulation of heart induction relationship: negatively_regulates GO:0003129 ! heart induction [Term] id: GO:0003137 name: Notch signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart] synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0061314 ! Notch signaling involved in heart development relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003138 name: primary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] synonym: "FHS specification" EXACT [GOC:rl] synonym: "first heart field specification" EXACT [GOC:rl] is_a: GO:0003128 ! heart field specification [Term] id: GO:0003139 name: secondary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] synonym: "anterior heart field specification" NARROW [GOC:mtg_heart] synonym: "second heart field specification" EXACT [GOC:mtg_heart, PMID:17276708] synonym: "SHF specification" EXACT [GOC:rl, PMID:22449840] is_a: GO:0003128 ! heart field specification [Term] id: GO:0003140 name: determination of left/right asymmetry in lateral mesoderm namespace: biological_process def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048368 ! lateral mesoderm development [Term] id: GO:0003141 name: transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart] comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm. synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_obsolete: true replaced_by: GO:1900164 [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation [Term] id: GO:0003146 name: heart jogging namespace: biological_process def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285] synonym: "cardiac jogging" EXACT [GOC:mtg_heart] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0060914 ! heart formation relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding [Term] id: GO:0003153 name: closure of embryonic heart tube namespace: biological_process def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart] is_a: GO:0060606 ! tube closure relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding [Term] id: GO:0003154 name: BMP signaling pathway involved in determination of left/right symmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling] synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0003155 name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm [Term] id: GO:0003156 name: regulation of organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0048645 ! organ formation [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities,and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0009888 ! tissue development [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0003158 ! endothelium development [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0003157 ! endocardium development [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0003166 name: bundle of His development namespace: biological_process def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0003167 name: atrioventricular bundle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003166 ! bundle of His development [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003165 ! Purkinje myocyte development [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0003170 name: heart valve development namespace: biological_process def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] synonym: "cardiac valve development" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003171 name: atrioventricular valve development namespace: biological_process def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "AV valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003172 name: sinoatrial valve development namespace: biological_process def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "SA valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003173 name: ventriculo bulbo valve development namespace: biological_process def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003174 name: mitral valve development namespace: biological_process def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003175 name: tricuspid valve development namespace: biological_process def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003176 name: aortic valve development namespace: biological_process def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003177 name: pulmonary valve development namespace: biological_process def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003178 name: coronary sinus valve development namespace: biological_process def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003179 name: heart valve morphogenesis namespace: biological_process def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf] synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0003170 ! heart valve development [Term] id: GO:0003180 name: aortic valve morphogenesis namespace: biological_process def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003176 ! aortic valve development [Term] id: GO:0003181 name: atrioventricular valve morphogenesis namespace: biological_process def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart] synonym: "AV valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003171 ! atrioventricular valve development [Term] id: GO:0003182 name: coronary sinus valve morphogenesis namespace: biological_process def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003178 ! coronary sinus valve development [Term] id: GO:0003183 name: mitral valve morphogenesis namespace: biological_process def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003174 ! mitral valve development [Term] id: GO:0003184 name: pulmonary valve morphogenesis namespace: biological_process def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003177 ! pulmonary valve development [Term] id: GO:0003185 name: sinoatrial valve morphogenesis namespace: biological_process def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart] synonym: "SA valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003172 ! sinoatrial valve development [Term] id: GO:0003186 name: tricuspid valve morphogenesis namespace: biological_process def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003175 ! tricuspid valve development [Term] id: GO:0003187 name: ventriculo bulbo valve morphogenesis namespace: biological_process def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003173 ! ventriculo bulbo valve development [Term] id: GO:0003188 name: heart valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003189 name: aortic valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003180 ! aortic valve morphogenesis [Term] id: GO:0003190 name: atrioventricular valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "AV valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis [Term] id: GO:0003191 name: coronary sinus valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis [Term] id: GO:0003192 name: mitral valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003183 ! mitral valve morphogenesis [Term] id: GO:0003193 name: pulmonary valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003184 ! pulmonary valve morphogenesis [Term] id: GO:0003194 name: sinoatrial valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "SA valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis [Term] id: GO:0003195 name: tricuspid valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003186 ! tricuspid valve morphogenesis [Term] id: GO:0003196 name: ventriculo bulbo valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003198 name: epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003272 ! endocardial cushion formation [Term] id: GO:0003199 name: endocardial cushion to mesenchymal transition involved in heart valve formation namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart] synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition relationship: part_of GO:0003188 ! heart valve formation [Term] id: GO:0003200 name: endocardial cushion to mesenchymal transition involved in heart chamber septation namespace: biological_process def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition relationship: part_of GO:0060411 ! cardiac septum morphogenesis [Term] id: GO:0003201 name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0003202 name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition relationship: part_of GO:0003204 ! cardiac skeleton development [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003231 ! cardiac ventricle development [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003230 ! cardiac atrium development [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003222 name: ventricular trabecula myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecula morphogenesis [Term] id: GO:0003223 name: ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis [Term] id: GO:0003224 name: left ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis [Term] id: GO:0003226 name: right ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003232 name: bulbus arteriosus development namespace: biological_process def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003233 name: bulbus arteriosus morphogenesis namespace: biological_process def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003232 ! bulbus arteriosus development [Term] id: GO:0003234 name: bulbus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003235 ! sinus venosus development [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003236 ! sinus venosus morphogenesis [Term] id: GO:0003238 name: conus arteriosus development namespace: biological_process def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003239 name: conus arteriosus morphogenesis namespace: biological_process def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003238 ! conus arteriosus development [Term] id: GO:0003240 name: conus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003239 ! conus arteriosus morphogenesis [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth [Term] id: GO:0003242 name: cardiac chamber ballooning namespace: biological_process def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis [Term] id: GO:0003243 name: circumferential growth involved in left ventricle morphogenesis namespace: biological_process def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003244 name: radial growth involved in right ventricle morphogenesis namespace: biological_process def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis [Term] id: GO:0003246 name: embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart] synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis [Term] id: GO:0003247 name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development [Term] id: GO:0003249 name: cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis is_a: GO:2000793 ! cell proliferation involved in heart valve development relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003250 name: regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003251 name: positive regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003252 name: negative regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis [Term] id: GO:0003254 name: regulation of membrane depolarization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:2000021 ! regulation of ion homeostasis relationship: regulates GO:0051899 ! membrane depolarization [Term] id: GO:0003255 name: endocardial precursor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation [Term] id: GO:0003256 name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:0003257 name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation is_a: GO:1901228 ! positive regulation of transcription from RNA polymerase II promoter involved in heart development relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:0003258 name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart] is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development relationship: part_of GO:0003255 ! endocardial precursor cell differentiation [Term] id: GO:0003259 name: cardioblast anterior-lateral migration namespace: biological_process def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003261 name: cardiac muscle progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart] synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation [Term] id: GO:0003262 name: endocardial progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation [Term] id: GO:0003263 name: cardioblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003264 name: regulation of cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003156 ! regulation of organ formation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: regulates GO:0003263 ! cardioblast proliferation [Term] id: GO:0003265 name: regulation of primary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] synonym: "regulation of FHF cardioblast proliferation" EXACT [GOC:rl] synonym: "regulation of first heart field cardiac proliferation" RELATED [] synonym: "regulation of first heart field cardioblast proliferation" EXACT [GOC:rl] is_a: GO:0003264 ! regulation of cardioblast proliferation [Term] id: GO:0003266 name: regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "regulation of SHF cardioblast proliferation " EXACT [GOC:rl] is_a: GO:0003264 ! regulation of cardioblast proliferation [Term] id: GO:0003267 name: canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0044340 ! canonical Wnt receptor signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development relationship: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003268 name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah] is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003269 name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003270 name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph] synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061314 ! Notch signaling involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003271 name: smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:bf] synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003272 ! endocardial cushion formation [Term] id: GO:0003274 name: endocardial cushion fusion namespace: biological_process def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0003276 name: apoptotic process involved in heart valve morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart valve morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003205 ! cardiac chamber development [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003231 ! cardiac ventricle development [Term] id: GO:0003282 name: ventricular septum intermedium development namespace: biological_process def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003281 ! ventricular septum development [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003230 ! cardiac atrium development [Term] id: GO:0003284 name: septum primum development namespace: biological_process def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003285 name: septum secundum development namespace: biological_process def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003286 name: atrial septum intermedium development namespace: biological_process def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003288 name: ventricular septum intermedium morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003289 name: atrial septum primum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003284 ! septum primum development [Term] id: GO:0003290 name: atrial septum secundum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003285 ! septum secundum development [Term] id: GO:0003291 name: atrial septum intermedium morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003286 ! atrial septum intermedium development [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003279 ! cardiac septum development [Term] id: GO:0003293 name: heart valve cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003170 ! heart valve development [Term] id: GO:0003294 name: atrial ventricular junction remodeling namespace: biological_process def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart] synonym: "atrio-ventricular junction remodeling " RELATED [GOC:mtg_heart] synonym: "atrioventricular junction remodeling " EXACT [GOC:mtg_heart] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003295 name: cell proliferation involved in atrial ventricular junction remodeling namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "cell proliferation involved in atrio-ventricular junction remodeling " EXACT [GOC:mtg_heart] synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0003294 ! atrial ventricular junction remodeling [Term] id: GO:0003296 name: apoptotic process involved in atrial ventricular junction remodeling namespace: biological_process def: "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in atrial ventricular junction remodeling" NARROW [] synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "apoptosis involved in atrioventricular junction remodeling " EXACT [GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003294 ! atrial ventricular junction remodeling [Term] id: GO:0003297 name: heart wedging namespace: biological_process def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0003299 name: muscle hypertrophy in response to stress namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] is_a: GO:0006950 ! response to stress is_a: GO:0014896 ! muscle hypertrophy is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: part_of GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0003302 name: transforming growth factor beta receptor signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling] synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003303 name: BMP signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003304 name: myocardial epithelial involution involved in heart jogging namespace: biological_process def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart] is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003305 name: cell migration involved in heart jogging namespace: biological_process def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003306 name: Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0016055 ! Wnt receptor signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development [Term] id: GO:0003307 name: regulation of Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development [Term] id: GO:0003308 name: negative regulation of Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway relationship: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0003313 ! heart rudiment development [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003314 ! heart rudiment morphogenesis [Term] id: GO:0003316 name: establishment of myocardial progenitor cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003317 name: cardioblast cell midline fusion namespace: biological_process def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003318 name: cell migration to the midline involved in heart development namespace: biological_process def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0003319 name: cardioblast migration to the midline involved in heart rudiment formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart] is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003320 name: heart rudiment involution namespace: biological_process def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart] is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation [Term] id: GO:0003321 name: positive regulation of blood pressure by epinephrine-norepinephrine namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph] is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine is_a: GO:0045777 ! positive regulation of blood pressure [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003309 ! type B pancreatic cell differentiation [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003311 ! pancreatic D cell differentiation [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003312 ! pancreatic PP cell differentiation [Term] id: GO:0003326 name: pancreatic A cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:0003327 name: type B pancreatic cell fate commitment namespace: biological_process def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003309 ! type B pancreatic cell differentiation [Term] id: GO:0003328 name: pancreatic D cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003311 ! pancreatic D cell differentiation [Term] id: GO:0003329 name: pancreatic PP cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003312 ! pancreatic PP cell differentiation [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0003334 name: keratinocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0030216 ! keratinocyte differentiation [Term] id: GO:0003335 name: corneocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0003334 ! keratinocyte development [Term] id: GO:0003336 name: corneocyte desquamation namespace: biological_process def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph] synonym: "epidermal desquamation" EXACT [GOC:dph] is_a: GO:0060232 ! delamination relationship: part_of GO:0003335 ! corneocyte development [Term] id: GO:0003337 name: mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] is_a: GO:0060231 ! mesenchymal to epithelial transition relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis [Term] id: GO:0003338 name: metanephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0003339 name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0003340 name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0003341 name: cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] synonym: "ciliary motility" RELATED [] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0003343 ! septum transversum development [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060039 ! pericardium development [Term] id: GO:0003345 name: proepicardium cell migration involved in pericardium morphogenesis namespace: biological_process def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003344 ! pericardium morphogenesis [Term] id: GO:0003346 name: epicardium-derived cell migration to the myocardium namespace: biological_process def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0003347 name: epicardial cell to mesenchymal cell transition namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343] is_a: GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation [Term] id: GO:0003349 name: epicardium-derived cardiac endothelial cell differentiation namespace: biological_process def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0003348 ! cardiac endothelial cell differentiation [Term] id: GO:0003350 name: pulmonary myocardium development namespace: biological_process def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060841 ! venous blood vessel development [Term] id: GO:0003351 name: epithelial cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph] synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0060632 ! regulation of microtubule-based movement relationship: regulates GO:0003341 ! cilium movement [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051272 ! positive regulation of cellular component movement relationship: positively_regulates GO:0003341 ! cilium movement [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051271 ! negative regulation of cellular component movement relationship: negatively_regulates GO:0003341 ! cilium movement [Term] id: GO:0003355 name: cilium movement involved in otolith formation namespace: biological_process def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph] is_a: GO:0003351 ! epithelial cilium movement relationship: part_of GO:0032475 ! otolith formation [Term] id: GO:0003356 name: regulation of cilium beat frequency namespace: biological_process def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003357 ! noradrenergic neuron differentiation [Term] id: GO:0003359 name: noradrenergic neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0003357 ! noradrenergic neuron differentiation [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation relationship: part_of GO:0003360 ! brainstem development [Term] id: GO:0003362 name: noradrenergic neuron fate commitment involved in brainstem development namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003359 ! noradrenergic neuron fate commitment relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development [Term] id: GO:0003363 name: lamellipodium assembly involved in ameboidal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030032 ! lamellipodium assembly relationship: part_of GO:0001667 ! ameboidal cell migration [Term] id: GO:0003364 name: lamellipodium assembly involved in mesendodermal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0001667 ! ameboidal cell migration [Term] id: GO:0003366 name: cell-matrix adhesion involved in ameboidal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007160 ! cell-matrix adhesion relationship: part_of GO:0001667 ! ameboidal cell migration [Term] id: GO:0003367 name: cell-cell adhesion involved in ameboidal cell migration namespace: biological_process def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration [Term] id: GO:0003368 name: cell-matrix adhesion involved in mesendodermal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003369 name: establishment of cell polarity involved in mesendodermal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003370 name: cell-cell adhesion involved in mesendodermal cell migration namespace: biological_process def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration [Term] id: GO:0003372 name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration [Term] id: GO:0003373 name: dynamin polymerization involved in membrane fission namespace: biological_process def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0090148 ! membrane fission [Term] id: GO:0003374 name: dynamin polymerization involved in mitochondrial fission namespace: biological_process def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003373 ! dynamin polymerization involved in membrane fission [Term] id: GO:0003375 name: regulation of dynamin polymerization involved in membrane fission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032271 ! regulation of protein polymerization relationship: regulates GO:0003373 ! dynamin polymerization involved in membrane fission [Term] id: GO:0003376 name: sphingosine-1-phosphate signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:22001186, Reactome:REACT_18416.2] comment: Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'. synonym: "S1P receptor signaling pathway" EXACT [GOC:bf] synonym: "S1P signaling pathway" EXACT [GOC:bf] synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf] synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186] synonym: "sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "sphingolipid signalling pathway" BROAD [GOC:mah] xref: Reactome:REACT_18416.2 "S1P-binding receptors bind S1P" is_a: GO:0007186 ! G-protein coupled receptor signaling pathway is_a: GO:0090520 ! sphingolipid mediated signaling pathway [Term] id: GO:0003377 name: regulation of apoptosis by sphingosine-1-phosphate signaling pathway namespace: biological_process def: "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb] synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah] is_a: GO:0003376 ! sphingosine-1-phosphate signaling pathway is_a: GO:0042981 ! regulation of apoptotic process [Term] id: GO:0003378 name: regulation of inflammatory response by sphingosine-1-phosphate signaling pathway namespace: biological_process def: "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah] is_a: GO:0003376 ! sphingosine-1-phosphate signaling pathway is_a: GO:0050727 ! regulation of inflammatory response [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration relationship: part_of GO:0042074 ! cell migration involved in gastrulation [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0003383 name: apical constriction namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0003382 ! epithelial cell morphogenesis [Term] id: GO:0003384 name: apical constriction involved in gastrulation namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003383 ! apical constriction relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation [Term] id: GO:0003385 name: cell-cell signaling involved in amphid sensory organ development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003386 name: amphid sensory organ development namespace: biological_process def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0003387 name: neuron differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003388 name: neuron development involved in amphid sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development [Term] id: GO:0003389 name: retrograde extension namespace: biological_process def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031175 ! neuron projection development [Term] id: GO:0003390 name: dendrite development by retrograde extension namespace: biological_process def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003389 ! retrograde extension is_a: GO:0016358 ! dendrite development [Term] id: GO:0003391 name: amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development [Term] id: GO:0003392 name: cell adhesion involved in retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007155 ! cell adhesion relationship: part_of GO:0003389 ! retrograde extension [Term] id: GO:0003393 name: neuron migration involved in retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001764 ! neuron migration relationship: part_of GO:0003389 ! retrograde extension [Term] id: GO:0003394 name: cell adhesion involved in dendrite retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003392 ! cell adhesion involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension [Term] id: GO:0003395 name: neuron migration involved in dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003393 ! neuron migration involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension [Term] id: GO:0003396 name: cell adhesion involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension [Term] id: GO:0003397 name: neuron migration involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension [Term] id: GO:0003398 name: glial cell differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003399 name: cytoneme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048858 ! cell projection morphogenesis [Term] id: GO:0003400 name: regulation of COPII vesicle coating namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis relationship: regulates GO:0048208 ! COPII vesicle coating [Term] id: GO:0003401 name: axis elongation namespace: biological_process def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0003402 name: planar cell polarity pathway involved in axis elongation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway relationship: part_of GO:0003401 ! axis elongation [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis [Term] id: GO:0003405 name: optic vesicle elongation namespace: biological_process def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis [Term] id: GO:0003406 name: retinal pigment epithelium development namespace: biological_process def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0003408 name: optic cup formation involved in camera-type eye development namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0003409 name: optic cup structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "optic cup structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0003410 name: anterior rotation of the optic cup namespace: biological_process def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0003412 name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis [Term] id: GO:0003415 name: chondrocyte hypertrophy namespace: biological_process def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0002063 ! chondrocyte development [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0003417 name: growth plate cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis relationship: part_of GO:0003416 ! endochondral bone growth [Term] id: GO:0003418 name: growth plate cartilage chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003419 name: growth plate cartilage chondrocyte proliferation namespace: biological_process def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003420 name: regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061035 ! regulation of cartilage development is_a: GO:2000027 ! regulation of organ morphogenesis relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation [Term] id: GO:0003421 name: growth plate cartilage axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification is_a: GO:0044767 ! single-organism developmental process relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003422 name: growth plate cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003423 name: growth plate cartilage chondrocyte division namespace: biological_process def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051301 ! cell division relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation [Term] id: GO:0003424 name: establishment of cell polarity involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division [Term] id: GO:0003425 name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000132 ! establishment of mitotic spindle orientation is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity [Term] id: GO:0003426 name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division [Term] id: GO:0003427 name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0051302 ! regulation of cell division is_a: GO:0051493 ! regulation of cytoskeleton organization is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway is_a: GO:2000114 ! regulation of establishment of cell polarity relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division [Term] id: GO:0003428 name: chondrocyte intercalation involved in growth plate cartilage morphogenesis namespace: biological_process def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0060029 ! convergent extension involved in organogenesis [Term] id: GO:0003429 name: growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation [Term] id: GO:0003430 name: growth plate cartilage chondrocyte growth namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003415 ! chondrocyte hypertrophy is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003431 name: growth plate cartilage chondrocyte development namespace: biological_process def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation [Term] id: GO:0003432 name: cell growth involved in growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003430 ! growth plate cartilage chondrocyte growth relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis [Term] id: GO:0003434 name: BMP signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003435 name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003436 name: regulation of cell adhesion involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003437 name: regulation of cell communication involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003673 name: Gene_Ontology namespace: biological_process def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "molecular function" EXACT [] synonym: "molecular function unknown" NARROW [] disjoint_from: GO:0005575 ! cellular_component disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0003675 name: protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_aspergillus subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003678 name: DNA helicase activity namespace: molecular_function alt_id: GO:0003679 def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] subset: gosubset_prok xref: Reactome:REACT_116013 "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA, Gallus gallus" is_a: GO:0004386 ! helicase activity [Term] id: GO:0003680 name: AT DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] synonym: "AT binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003681 name: bent DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] subset: gosubset_prok is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_pir subset: goslim_plant synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0005488 ! binding [Term] id: GO:0003683 name: lamin/chromatin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two functions. is_obsolete: true replaced_by: GO:0003682 replaced_by: GO:0005521 [Term] id: GO:0003684 name: damaged DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] subset: gosubset_prok synonym: "DNA repair enzyme" RELATED [] synonym: "DNA repair protein" RELATED [] xref: Reactome:REACT_100664 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Rattus norvegicus" xref: Reactome:REACT_101048 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Bos taurus" xref: Reactome:REACT_101116 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Xenopus tropicalis" xref: Reactome:REACT_103019 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Rattus norvegicus" xref: Reactome:REACT_103328 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Mus musculus" xref: Reactome:REACT_103380 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Xenopus tropicalis" xref: Reactome:REACT_103899 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Taeniopygia guttata" xref: Reactome:REACT_104175 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Danio rerio" xref: Reactome:REACT_104346 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Bos taurus" xref: Reactome:REACT_105157 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Bos taurus" xref: Reactome:REACT_105628 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Danio rerio" xref: Reactome:REACT_106525 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Taeniopygia guttata" xref: Reactome:REACT_110972 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Mus musculus" xref: Reactome:REACT_110979 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Mus musculus" xref: Reactome:REACT_113582 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Arabidopsis thaliana" xref: Reactome:REACT_113713 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Arabidopsis thaliana" xref: Reactome:REACT_113838 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Oryza sativa" xref: Reactome:REACT_114851 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Oryza sativa" xref: Reactome:REACT_1435 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Homo sapiens" xref: Reactome:REACT_1696 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Homo sapiens" xref: Reactome:REACT_1934 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Homo sapiens" xref: Reactome:REACT_2185 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Homo sapiens" xref: Reactome:REACT_28366 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Gallus gallus" xref: Reactome:REACT_29673 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Mycobacterium tuberculosis" xref: Reactome:REACT_30891 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Danio rerio" xref: Reactome:REACT_31436 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Sus scrofa" xref: Reactome:REACT_33416 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Mus musculus" xref: Reactome:REACT_33600 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Canis familiaris" xref: Reactome:REACT_33888 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Xenopus tropicalis" xref: Reactome:REACT_462 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Homo sapiens" xref: Reactome:REACT_52866 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Bos taurus" xref: Reactome:REACT_77587 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Danio rerio" xref: Reactome:REACT_783 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Homo sapiens" xref: Reactome:REACT_79824 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Sus scrofa" xref: Reactome:REACT_81071 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Canis familiaris" xref: Reactome:REACT_81112 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Canis familiaris" xref: Reactome:REACT_81735 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Sus scrofa" xref: Reactome:REACT_82167 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Gallus gallus" xref: Reactome:REACT_83944 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Bos taurus" xref: Reactome:REACT_84763 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Gallus gallus" xref: Reactome:REACT_84781 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Rattus norvegicus" xref: Reactome:REACT_84951 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Xenopus tropicalis" xref: Reactome:REACT_85779 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Oryza sativa" xref: Reactome:REACT_86067 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Taeniopygia guttata" xref: Reactome:REACT_87009 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Rattus norvegicus" xref: Reactome:REACT_88774 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Canis familiaris" xref: Reactome:REACT_88901 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Canis familiaris" xref: Reactome:REACT_89666 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Xenopus tropicalis" xref: Reactome:REACT_89685 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Mycobacterium tuberculosis" xref: Reactome:REACT_89917 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Danio rerio" xref: Reactome:REACT_90545 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Canis familiaris" xref: Reactome:REACT_91221 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Bos taurus" xref: Reactome:REACT_91729 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Gallus gallus" xref: Reactome:REACT_91817 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Taeniopygia guttata" xref: Reactome:REACT_92004 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Danio rerio" xref: Reactome:REACT_92429 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Mus musculus" xref: Reactome:REACT_93699 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Taeniopygia guttata" xref: Reactome:REACT_93716 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Gallus gallus" xref: Reactome:REACT_93739 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Mycobacterium tuberculosis" xref: Reactome:REACT_94142 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Xenopus tropicalis" xref: Reactome:REACT_94682 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Mus musculus" xref: Reactome:REACT_95130 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Arabidopsis thaliana" xref: Reactome:REACT_97138 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Rattus norvegicus" xref: Reactome:REACT_97358 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Rattus norvegicus" xref: Reactome:REACT_98435 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Taeniopygia guttata" xref: Reactome:REACT_98953 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Gallus gallus" is_a: GO:0003677 ! DNA binding [Term] id: GO:0003685 name: DNA repair protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. is_obsolete: true consider: GO:0003684 [Term] id: GO:0003686 name: DNA repair enzyme namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. is_obsolete: true consider: GO:0003684 [Term] id: GO:0003687 name: DNA replication factor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. is_obsolete: true consider: GO:0006260 [Term] id: GO:0003688 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] subset: gosubset_prok synonym: "ARS binding" NARROW [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003689 name: DNA clamp loader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] subset: gosubset_prok synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] xref: Reactome:REACT_106382 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster" xref: Reactome:REACT_107423 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans" xref: Reactome:REACT_113703 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus" xref: Reactome:REACT_29764 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata" xref: Reactome:REACT_33572 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum" xref: Reactome:REACT_50018 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus" xref: Reactome:REACT_6729 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens" xref: Reactome:REACT_79188 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris" xref: Reactome:REACT_88384 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe" xref: Reactome:REACT_90809 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio" xref: Reactome:REACT_92527 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus" xref: Reactome:REACT_92644 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis" xref: Reactome:REACT_96998 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus" is_a: GO:0003677 ! DNA binding is_a: GO:0033170 ! protein-DNA loading ATPase activity [Term] id: GO:0003690 name: double-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh] subset: gosubset_prok synonym: "dsDNA binding" EXACT [GOC:elh] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003691 name: double-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0042162 ! telomeric DNA binding [Term] id: GO:0003692 name: left-handed Z-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003693 name: P-element binding namespace: molecular_function def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003694 name: plasmid binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732] comment: This term was made obsolete because it refers to component information. synonym: "plasmid-associated protein" RELATED [] is_obsolete: true consider: GO:0003677 consider: GO:0005727 [Term] id: GO:0003695 name: random coil DNA binding namespace: molecular_function alt_id: GO:0016017 def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah] synonym: "random coil binding" EXACT [] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003696 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003697 name: single-stranded DNA binding namespace: molecular_function alt_id: GO:0003698 alt_id: GO:0003699 def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh] comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. subset: gosubset_prok synonym: "ssDNA binding" EXACT [GOC:mah] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003700 name: sequence-specific DNA binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] subset: goslim_plant subset: gosubset_prok synonym: "transcription factor activity" BROAD [] is_a: GO:0001071 ! nucleic acid binding transcription factor activity [Term] id: GO:0003701 name: RNA polymerase I transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0001082 consider: GO:0001167 consider: GO:0006360 [Term] id: GO:0003702 name: RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000981 consider: GO:0000991 consider: GO:0001076 consider: GO:0006366 [Term] id: GO:0003704 name: specific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000981 consider: GO:0000991 consider: GO:0001076 consider: GO:0006366 [Term] id: GO:0003705 name: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" EXACT [] is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0003706 name: ligand-regulated transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators] comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. is_obsolete: true consider: GO:0004879 consider: GO:0038049 [Term] id: GO:0003707 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'. is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0003708 name: retinoic acid receptor activity namespace: molecular_function def: "Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A." [GOC:signaling, PMID:1328967] synonym: "vitamin A receptor activity" BROAD [] is_a: GO:0004879 ! ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [Term] id: GO:0003709 name: RNA polymerase III transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. is_obsolete: true consider: GO:0000995 consider: GO:0001007 consider: GO:0001034 consider: GO:0006383 [Term] id: GO:0003711 name: transcription elongation regulator activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcription elongation factor activity" EXACT [] synonym: "transcriptional elongation regulator activity" EXACT [] is_obsolete: true consider: GO:0032784 [Term] id: GO:0003712 name: transcription cofactor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] subset: gosubset_prok synonym: "transcriptional co-regulator" EXACT [] synonym: "transcriptional cofactor activity" EXACT [] is_a: GO:0000989 ! transcription factor binding transcription factor activity [Term] id: GO:0003713 name: transcription coactivator activity namespace: molecular_function def: "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] subset: gosubset_prok synonym: "transcription co-activator activity" EXACT [] is_a: GO:0003712 ! transcription cofactor activity [Term] id: GO:0003714 name: transcription corepressor activity namespace: molecular_function def: "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] synonym: "transcription co-repressor activity" EXACT [] is_a: GO:0003712 ! transcription cofactor activity [Term] id: GO:0003715 name: transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. subset: gosubset_prok synonym: "transcriptional termination factor activity" EXACT [] is_obsolete: true consider: GO:0006353 [Term] id: GO:0003716 name: RNA polymerase I transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006363 [Term] id: GO:0003717 name: RNA polymerase II transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006369 [Term] id: GO:0003718 name: RNA polymerase III transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006386 [Term] id: GO:0003719 name: transcription factor binding, cytoplasmic sequestering namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process rather than a function. is_obsolete: true replaced_by: GO:0042994 [Term] id: GO:0003720 name: telomerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] xref: EC:2.7.7.- xref: Reactome:REACT_104705 "Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae" xref: Reactome:REACT_106476 "Elongation Of The Telomeric Chromosome End, Bos taurus" xref: Reactome:REACT_108407 "Elongation of Extended Telomeric Chromosome End, Oryza sativa" xref: Reactome:REACT_109443 "Elongation Of The Telomeric Chromosome End, Danio rerio" xref: Reactome:REACT_113385 "Elongation Of The Telomeric Chromosome End, Xenopus tropicalis" xref: Reactome:REACT_114466 "Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis" xref: Reactome:REACT_115824 "Elongation and translocation of the extended telomeric chromosome end, Gallus gallus" xref: Reactome:REACT_116122 "Elongation and translocation of the telomeric chromosome end, Gallus gallus" xref: Reactome:REACT_28249 "Elongation of Extended Telomeric Chromosome End, Gallus gallus" xref: Reactome:REACT_30494 "Elongation Of The Telomeric Chromosome End, Sus scrofa" xref: Reactome:REACT_30995 "Elongation Of The Telomeric Chromosome End, Canis familiaris" xref: Reactome:REACT_31549 "Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae" xref: Reactome:REACT_33436 "Elongation of Extended Telomeric Chromosome End, Danio rerio" xref: Reactome:REACT_77280 "Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana" xref: Reactome:REACT_7985 "Elongation of Extended Telomeric Chromosome End, Homo sapiens" xref: Reactome:REACT_8019 "Elongation Of The Telomeric Chromosome End, Homo sapiens" xref: Reactome:REACT_80834 "Elongation Of The Telomeric Chromosome End, Mus musculus" xref: Reactome:REACT_81691 "Elongation of Extended Telomeric Chromosome End, Canis familiaris" xref: Reactome:REACT_83982 "Elongation Of The Telomeric Chromosome End, Oryza sativa" xref: Reactome:REACT_85286 "Elongation of Extended Telomeric Chromosome End, Bos taurus" xref: Reactome:REACT_86666 "Elongation of Extended Telomeric Chromosome End, Sus scrofa" xref: Reactome:REACT_90823 "Elongation of Extended Telomeric Chromosome End, Mus musculus" xref: Reactome:REACT_93232 "Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe" xref: Reactome:REACT_94534 "Elongation Of The Telomeric Chromosome End, Taeniopygia guttata" xref: Reactome:REACT_94768 "Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe" xref: Reactome:REACT_95176 "Elongation Of The Telomeric Chromosome End, Gallus gallus" xref: Reactome:REACT_96912 "Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata" xref: Reactome:REACT_97770 "Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana" is_a: GO:0003964 ! RNA-directed DNA polymerase activity [Term] id: GO:0003721 name: telomeric template RNA reverse transcriptase activity namespace: molecular_function def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] synonym: "telomerase, catalyst" EXACT [] is_a: GO:0003964 ! RNA-directed DNA polymerase activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0003723 name: RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_101703 "Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis" xref: Reactome:REACT_103323 "Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum" xref: Reactome:REACT_106430 "Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus" xref: Reactome:REACT_107757 "Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster" xref: Reactome:REACT_108232 "Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa" xref: Reactome:REACT_108368 "Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_109723 "Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana" xref: Reactome:REACT_12458 "Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens" xref: Reactome:REACT_29965 "Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris" xref: Reactome:REACT_77167 "Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus" xref: Reactome:REACT_78197 "Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa" xref: Reactome:REACT_87164 "Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_89329 "Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus" xref: Reactome:REACT_90531 "Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio" xref: Reactome:REACT_98683 "Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003724 name: RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus" xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens" xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio" xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris" xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster" xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis" is_a: GO:0004386 ! helicase activity [Term] id: GO:0003725 name: double-stranded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] subset: gosubset_prok synonym: "dsRNA binding" EXACT [GOC:ecd] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003726 name: double-stranded RNA adenosine deaminase activity namespace: molecular_function alt_id: GO:0003971 def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] subset: gosubset_prok synonym: "double-stranded RNA specific editase activity" RELATED [] xref: Reactome:REACT_100080 "Deamination at C6 position of adenosine in Editosome (ADAR2), Taeniopygia guttata" xref: Reactome:REACT_104541 "Deamination at C6 position of adenosine in Editosome (ADAR1), Sus scrofa" xref: Reactome:REACT_110356 "Deamination at C6 position of adenosine in Editosome (ADAR1), Xenopus tropicalis" xref: Reactome:REACT_1105 "Deamination at C6 position of adenosine in Editosome (ADAR1), Homo sapiens" xref: Reactome:REACT_112019 "Deamination at C6 position of adenosine in Editosome (ADAR1), Oryza sativa" xref: Reactome:REACT_112024 "Deamination at C6 position of adenosine in Editosome (ADAR1), Saccharomyces cerevisiae" xref: Reactome:REACT_113770 "Deamination at C6 position of adenosine in Editosome (ADAR1), Caenorhabditis elegans" xref: Reactome:REACT_114900 "Deamination at C6 position of adenosine in Editosome (ADAR1), Arabidopsis thaliana" xref: Reactome:REACT_115470 "Deamination at C6 position of adenosine in Editosome (ADAR1), Schizosaccharomyces pombe" xref: Reactome:REACT_29892 "Deamination at C6 position of adenosine in Editosome (ADAR2), Canis familiaris" xref: Reactome:REACT_31966 "Deamination at C6 position of adenosine in Editosome (ADAR1), Canis familiaris" xref: Reactome:REACT_32015 "Deamination at C6 position of adenosine in Editosome (ADAR2), Xenopus tropicalis" xref: Reactome:REACT_365 "Deamination at C6 position of adenosine in Editosome (ADAR2), Homo sapiens" xref: Reactome:REACT_79183 "Deamination at C6 position of adenosine in Editosome (ADAR2), Mus musculus" xref: Reactome:REACT_79641 "Deamination at C6 position of adenosine in Editosome (ADAR1), Taeniopygia guttata" xref: Reactome:REACT_80597 "Deamination at C6 position of adenosine in Editosome (ADAR2), Gallus gallus" xref: Reactome:REACT_80662 "Deamination at C6 position of adenosine in Editosome (ADAR2), Bos taurus" xref: Reactome:REACT_86066 "Deamination at C6 position of adenosine in Editosome (ADAR2), Sus scrofa" xref: Reactome:REACT_86370 "Deamination at C6 position of adenosine in Editosome (ADAR1), Gallus gallus" xref: Reactome:REACT_86554 "Deamination at C6 position of adenosine in Editosome (ADAR1), Rattus norvegicus" xref: Reactome:REACT_87527 "Deamination at C6 position of adenosine in Editosome (ADAR1), Mus musculus" xref: Reactome:REACT_90605 "Deamination at C6 position of adenosine in Editosome (ADAR2), Rattus norvegicus" xref: Reactome:REACT_90645 "Deamination at C6 position of adenosine in Editosome (ADAR2), Danio rerio" xref: Reactome:REACT_92526 "Deamination at C6 position of adenosine in Editosome (ADAR2), Drosophila melanogaster" xref: Reactome:REACT_99543 "Deamination at C6 position of adenosine in Editosome (ADAR1), Bos taurus" xref: Reactome:REACT_99769 "Deamination at C6 position of adenosine in Editosome (ADAR1), Danio rerio" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0003727 name: single-stranded RNA binding namespace: molecular_function alt_id: GO:0003728 def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] synonym: "ssRNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] subset: goslim_generic subset: goslim_yeast subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0003730 name: mRNA 3'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0003731 name: mRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. is_obsolete: true consider: GO:0000339 [Term] id: GO:0003732 name: snRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. is_obsolete: true consider: GO:0000339 [Term] id: GO:0003733 name: ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. is_obsolete: true replaced_by: GO:0030529 [Term] id: GO:0003734 name: small nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "snRNP" EXACT [] is_obsolete: true replaced_by: GO:0030532 [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0003743 name: translation initiation factor activity namespace: molecular_function alt_id: GO:0003744 alt_id: GO:0003745 def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] subset: gosubset_prok xref: Reactome:REACT_102411 "eIF2 activation, Arabidopsis thaliana" xref: Reactome:REACT_102747 "Ribosomal scanning, Plasmodium falciparum" xref: Reactome:REACT_104592 "Ribosomal scanning, Xenopus tropicalis" xref: Reactome:REACT_104947 "Start codon recognition, Arabidopsis thaliana" xref: Reactome:REACT_105336 "Ribosomal scanning, Danio rerio" xref: Reactome:REACT_105545 "eIF2 activation, Schizosaccharomyces pombe" xref: Reactome:REACT_105772 "Ribosomal scanning, Caenorhabditis elegans" xref: Reactome:REACT_106049 "Ribosomal scanning, Schizosaccharomyces pombe" xref: Reactome:REACT_107324 "eIF2 activation, Taeniopygia guttata" xref: Reactome:REACT_108980 "Ribosomal scanning, Canis familiaris" xref: Reactome:REACT_112013 "Start codon recognition, Gallus gallus" xref: Reactome:REACT_114676 "Ribosomal scanning, Gallus gallus" xref: Reactome:REACT_115071 "Ribosomal scanning, Rattus norvegicus" xref: Reactome:REACT_115079 "Start codon recognition, Rattus norvegicus" xref: Reactome:REACT_115451 "Start codon recognition, Bos taurus" xref: Reactome:REACT_1401 "eIF2 activation, Homo sapiens" xref: Reactome:REACT_1516 "Ribosomal scanning, Homo sapiens" xref: Reactome:REACT_29285 "eIF2 activation, Danio rerio" xref: Reactome:REACT_31248 "Ribosomal scanning, Drosophila melanogaster" xref: Reactome:REACT_31637 "Start codon recognition, Saccharomyces cerevisiae" xref: Reactome:REACT_32686 "eIF2 activation, Oryza sativa" xref: Reactome:REACT_33398 "Start codon recognition, Oryza sativa" xref: Reactome:REACT_33544 "Start codon recognition, Xenopus tropicalis" xref: Reactome:REACT_57036 "Start codon recognition, Plasmodium falciparum" xref: Reactome:REACT_60464 "eIF2 activation, Caenorhabditis elegans" xref: Reactome:REACT_656 "Start codon recognition, Homo sapiens" xref: Reactome:REACT_78159 "Start codon recognition, Caenorhabditis elegans" xref: Reactome:REACT_78773 "eIF2 activation, Plasmodium falciparum" xref: Reactome:REACT_79007 "Start codon recognition, Danio rerio" xref: Reactome:REACT_81171 "Start codon recognition, Mus musculus" xref: Reactome:REACT_82224 "eIF2 activation, Gallus gallus" xref: Reactome:REACT_83059 "eIF2 activation, Bos taurus" xref: Reactome:REACT_83547 "eIF2 activation, Rattus norvegicus" xref: Reactome:REACT_83592 "eIF2 activation, Saccharomyces cerevisiae" xref: Reactome:REACT_88632 "eIF2 activation, Mus musculus" xref: Reactome:REACT_88913 "Ribosomal scanning, Bos taurus" xref: Reactome:REACT_88955 "eIF2 activation, Xenopus tropicalis" xref: Reactome:REACT_91084 "Ribosomal scanning, Arabidopsis thaliana" xref: Reactome:REACT_91415 "Start codon recognition, Dictyostelium discoideum" xref: Reactome:REACT_91967 "Ribosomal scanning, Dictyostelium discoideum" xref: Reactome:REACT_91979 "Ribosomal scanning, Taeniopygia guttata" xref: Reactome:REACT_93372 "Start codon recognition, Schizosaccharomyces pombe" xref: Reactome:REACT_93678 "eIF2 activation, Canis familiaris" xref: Reactome:REACT_95840 "Ribosomal scanning, Saccharomyces cerevisiae" xref: Reactome:REACT_96533 "Ribosomal scanning, Oryza sativa" xref: Reactome:REACT_96726 "eIF2 activation, Dictyostelium discoideum" xref: Reactome:REACT_99607 "Ribosomal scanning, Mus musculus" is_a: GO:0008135 ! translation factor activity, nucleic acid binding [Term] id: GO:0003746 name: translation elongation factor activity namespace: molecular_function alt_id: GO:0008182 alt_id: GO:0008183 def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] subset: gosubset_prok xref: Reactome:REACT_9514 "Viral Protein Synthesis, Homo sapiens" xref: Reactome:REACT_9524 "Synthesis of PB1-F2, Homo sapiens" is_a: GO:0008135 ! translation factor activity, nucleic acid binding [Term] id: GO:0003747 name: translation release factor activity namespace: molecular_function alt_id: GO:0003748 alt_id: GO:0003749 def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] subset: gosubset_prok is_a: GO:0008079 ! translation termination factor activity [Term] id: GO:0003750 name: cell cycle regulator namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a single molecular function. is_obsolete: true replaced_by: GO:0051726 [Term] id: GO:0003754 name: chaperone activity namespace: molecular_function alt_id: GO:0003757 alt_id: GO:0003758 alt_id: GO:0003760 alt_id: GO:0003761 def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003755 name: peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function alt_id: GO:0004752 alt_id: GO:0042028 def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] subset: gosubset_prok synonym: "cis-trans proline isomerase activity" EXACT [] synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] synonym: "immunophilin" RELATED [] synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah] synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah] synonym: "parvulin" RELATED [] synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] synonym: "PPIase activity" EXACT [EC:5.2.1.8] synonym: "rotamase activity" EXACT [EC:5.2.1.8] xref: EC:5.2.1.8 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0003756 name: protein disulfide isomerase activity namespace: molecular_function alt_id: GO:0006467 def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] subset: gosubset_prok synonym: "disulphide bond biosynthesis" EXACT [] synonym: "disulphide bond formation" EXACT [] synonym: "protein cysteine-thiol oxidation" RELATED [] synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] synonym: "protein disulphide isomerase activity" EXACT [] synonym: "protein thiol-disulfide exchange" EXACT [] synonym: "protein thiol-disulphide exchange" EXACT [] synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] xref: EC:5.3.4.1 xref: MetaCyc:5.3.4.1-RXN is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds [Term] id: GO:0003759 name: glycoprotein-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003762 name: histone-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "nucleosome assembly chaperone" EXACT [] is_obsolete: true consider: GO:0006333 consider: GO:0006334 consider: GO:0034728 consider: GO:0042393 consider: GO:0043486 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003763 name: chaperonin ATPase activity namespace: molecular_function alt_id: GO:0003764 alt_id: GO:0003765 alt_id: GO:0003766 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "chaperonin" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0003767 name: co-chaperone activity namespace: molecular_function alt_id: GO:0003768 alt_id: GO:0003769 alt_id: GO:0003770 alt_id: GO:0003771 def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003772 name: co-chaperonin activity namespace: molecular_function def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003773 name: heat shock protein activity namespace: molecular_function def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006986 consider: GO:0042026 [Term] id: GO:0003774 name: motor activity namespace: molecular_function def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003775 name: axonemal motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. is_obsolete: true consider: GO:0003777 consider: GO:0005930 [Term] id: GO:0003776 name: muscle motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes anatomy information. is_obsolete: true replaced_by: GO:0000146 consider: GO:0006936 consider: GO:0043292 [Term] id: GO:0003777 name: microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: Reactome:REACT_102513 "Axonal transport of NGF:Trk complexes, Danio rerio" xref: Reactome:REACT_103791 "Translocation of Insulin Secretory Granules to Cell Cortex, Danio rerio" xref: Reactome:REACT_105852 "Translocation of Insulin Secretory Granules to Cell Cortex, Bos taurus" xref: Reactome:REACT_106252 "Translocation of Insulin Secretory Granules to Cell Cortex, Xenopus tropicalis" xref: Reactome:REACT_113466 "Axonal transport of NGF:Trk complexes, Caenorhabditis elegans" xref: Reactome:REACT_115371 "Translocation of Insulin Secretory Granules to Cell Cortex, Gallus gallus" xref: Reactome:REACT_12385 "Axonal transport of NGF:Trk complexes, Homo sapiens" xref: Reactome:REACT_15477 "Translocation of Insulin Secretory Granules to Cell Cortex, Homo sapiens" xref: Reactome:REACT_20570 "Translocation of Insulin Secretory Granules to Cell Cortex, Mus musculus" xref: Reactome:REACT_31982 "Axonal transport of NGF:Trk complexes, Sus scrofa" xref: Reactome:REACT_32872 "Axonal transport of NGF:Trk complexes, Mus musculus" xref: Reactome:REACT_33543 "Translocation of Insulin Secretory Granules to Cell Cortex, Rattus norvegicus" xref: Reactome:REACT_77014 "Axonal transport of NGF:Trk complexes, Drosophila melanogaster" xref: Reactome:REACT_78584 "Axonal transport of NGF:Trk complexes, Gallus gallus" xref: Reactome:REACT_86678 "Translocation of Insulin Secretory Granules to Cell Cortex, Canis familiaris" xref: Reactome:REACT_87390 "Axonal transport of NGF:Trk complexes, Bos taurus" xref: Reactome:REACT_89365 "Axonal transport of NGF:Trk complexes, Taeniopygia guttata" xref: Reactome:REACT_92428 "Translocation of Insulin Secretory Granules to Cell Cortex, Taeniopygia guttata" xref: Reactome:REACT_94549 "Axonal transport of NGF:Trk complexes, Canis familiaris" xref: Reactome:REACT_95164 "Axonal transport of NGF:Trk complexes, Xenopus tropicalis" is_a: GO:0003774 ! motor activity [Term] id: GO:0003778 name: dynactin motor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. is_obsolete: true [Term] id: GO:0003779 name: actin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] synonym: "membrane associated actin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0003780 name: actin cross-linking activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid] comment: This term was made obsolete because it represents a combination of molecular functions. is_obsolete: true replaced_by: GO:0030674 replaced_by: GO:0051015 [Term] id: GO:0003781 name: actin bundling activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0051017 [Term] id: GO:0003782 name: F-actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003783 name: barbed-end actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003784 name: barbed-end actin capping/severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes two biological processes. is_obsolete: true replaced_by: GO:0051014 replaced_by: GO:0051016 [Term] id: GO:0003785 name: actin monomer binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai] synonym: "G actin binding" EXACT [] is_a: GO:0003779 ! actin binding [Term] id: GO:0003786 name: actin lateral binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah] is_a: GO:0051015 ! actin filament binding [Term] id: GO:0003787 name: actin depolymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0030042 [Term] id: GO:0003788 name: actin monomer sequestering activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process, not an activity. is_obsolete: true replaced_by: GO:0042989 [Term] id: GO:0003789 name: actin filament severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051014 [Term] id: GO:0003790 name: actin modulating activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not make sense. is_obsolete: true consider: GO:0030036 [Term] id: GO:0003791 name: membrane associated actin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0003779 consider: GO:0016020 [Term] id: GO:0003792 name: regulation of actin thin filament length activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the term belongs in the process ontology. is_obsolete: true replaced_by: GO:0030832 [Term] id: GO:0003793 name: defense/immunity protein activity namespace: molecular_function def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "defence/immunity protein activity" EXACT [] is_obsolete: true consider: GO:0006952 [Term] id: GO:0003794 name: acute-phase response protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0006953 [Term] id: GO:0003795 name: antimicrobial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0006952 [Term] id: GO:0003796 name: lysozyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] subset: gosubset_prok synonym: "1,4-N-acetylmuramidase activity" EXACT [] synonym: "globulin G" RELATED [EC:3.2.1.17] synonym: "globulin G1" RELATED [EC:3.2.1.17] synonym: "L-7001" RELATED [EC:3.2.1.17] synonym: "lysozyme g" RELATED [EC:3.2.1.17] synonym: "mucopeptide glucohydrolase activity" EXACT [] synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] synonym: "muramidase activity" EXACT [] synonym: "N,O-diacetylmuramidase activity" EXACT [] synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] xref: EC:3.2.1.17 xref: MetaCyc:3.2.1.17-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003797 name: antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0042742 [Term] id: GO:0003798 name: male-specific antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050831 [Term] id: GO:0003799 name: antifungal peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050832 [Term] id: GO:0003800 name: antiviral response protein activity namespace: molecular_function def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0009615 [Term] id: GO:0003801 name: blood coagulation factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0004252 consider: GO:0007596 [Term] id: GO:0003802 name: coagulation factor VIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] xref: EC:3.4.21.21 xref: MetaCyc:3.4.21.21-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003803 name: coagulation factor IXa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] synonym: "activated christmas factor" RELATED [EC:3.4.21.22] synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] synonym: "blood coagulation factor IX activity" EXACT [] synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] xref: EC:3.4.21.22 xref: MetaCyc:3.4.21.22-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003804 name: coagulation factor Xa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] synonym: "activated factor X" RELATED [EC:3.4.21.6] synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] synonym: "blood coagulation factor X activity" EXACT [] synonym: "factor Xa" RELATED [EC:3.4.21.6] synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] synonym: "prothrombase activity" EXACT [EC:3.4.21.6] synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] xref: EC:3.4.21.6 xref: MetaCyc:3.4.21.6-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003805 name: coagulation factor XIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] xref: EC:3.4.21.27 xref: MetaCyc:3.4.21.27-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003806 name: coagulation factor XIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] comment: This term was made obsolete because it represents a gene product. synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] synonym: "blood coagulation factor XII activity" EXACT [] synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] synonym: "hageman factor activity" EXACT [EC:3.4.21.38] synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] xref: EC:3.4.21.38 xref: MetaCyc:3.4.21.38-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003807 name: plasma kallikrein activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.34] synonym: "callicrein" RELATED [EC:3.4.21.34] synonym: "depot-padutin" RELATED [EC:3.4.21.34] synonym: "dilminal D" RELATED [EC:3.4.21.34] synonym: "glumorin" RELATED [EC:3.4.21.34] synonym: "kallidinogenase" BROAD [EC:3.4.21.34] synonym: "kallikrein" RELATED [EC:3.4.21.34] synonym: "kallikrein I" RELATED [EC:3.4.21.34] synonym: "kallikrein II" RELATED [EC:3.4.21.34] synonym: "kininogenase" BROAD [EC:3.4.21.34] synonym: "kininogenin activity" RELATED [EC:3.4.21.34] synonym: "onokrein P" RELATED [EC:3.4.21.34] synonym: "padreatin" RELATED [EC:3.4.21.34] synonym: "padutin" RELATED [EC:3.4.21.34] synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] xref: EC:3.4.21.34 xref: MetaCyc:3.4.21.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003808 name: protein C (activated) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] synonym: "activated protein C" RELATED [EC:3.4.21.69] synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein Ca" RELATED [EC:3.4.21.69] xref: EC:3.4.21.69 xref: MetaCyc:3.4.21.69-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003809 name: thrombin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] synonym: "beta-thrombin" RELATED [EC:3.4.21.5] synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] synonym: "E thrombin" RELATED [EC:3.4.21.5] synonym: "factor IIa" RELATED [EC:3.4.21.5] synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] synonym: "thrombase activity" EXACT [EC:3.4.21.5] synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] xref: EC:3.4.21.5 xref: MetaCyc:3.4.21.5-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003810 name: protein-glutamine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] subset: gosubset_prok synonym: "factor XIIIa" RELATED [EC:2.3.2.13] synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] synonym: "fibrinoligase activity" EXACT [] synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] synonym: "TGase activity" EXACT [] synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] synonym: "transglutaminase activity" EXACT [] xref: EC:2.3.2.13 xref: MetaCyc:2.3.2.13-RXN xref: Reactome:REACT_101525 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Canis familiaris" xref: Reactome:REACT_112106 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Drosophila melanogaster" xref: Reactome:REACT_112367 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Sus scrofa" xref: Reactome:REACT_112902 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Xenopus tropicalis" xref: Reactome:REACT_1852 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Homo sapiens" xref: Reactome:REACT_37344 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Gallus gallus" xref: Reactome:REACT_82525 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Bos taurus" xref: Reactome:REACT_82887 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Rattus norvegicus" xref: Reactome:REACT_89774 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Danio rerio" xref: Reactome:REACT_97354 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Taeniopygia guttata" xref: Reactome:REACT_98243 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Mus musculus" xref: RESID:AA0124 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003811 name: complement activity namespace: molecular_function def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0006956 [Term] id: GO:0003812 name: alternative-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] comment: This term was made obsolete because it represents a gene product. synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] synonym: "C3 proactivator" RELATED [EC:3.4.21.47] synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] synonym: "complement factor B activity" EXACT [EC:3.4.21.47] synonym: "CVF,Bb" RELATED [EC:3.4.21.47] synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] xref: EC:3.4.21.47 xref: MetaCyc:3.4.21.47-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003813 name: classical-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] comment: This term was made obsolete because it represents a gene product. synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] synonym: "C42" RELATED [EC:3.4.21.43] synonym: "C423" RELATED [EC:3.4.21.43] synonym: "C4b,2a" RELATED [EC:3.4.21.43] synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] xref: EC:3.4.21.43 xref: MetaCyc:3.4.21.43-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003815 name: complement component C1r activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] xref: EC:3.4.21.41 xref: MetaCyc:3.4.21.41-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003816 name: complement component C1s activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1s" RELATED [EC:3.4.21.42] synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] xref: EC:3.4.21.42 xref: MetaCyc:3.4.21.42-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003817 name: complement factor D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] comment: This term was made obsolete because it represents a gene product. synonym: "adipsin" EXACT [] synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] xref: EC:3.4.21.46 xref: MetaCyc:3.4.21.46-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003818 name: complement factor I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] comment: This term was made obsolete because it represents a gene product. synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] synonym: "C3bINA" RELATED [EC:3.4.21.45] synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4bi" RELATED [EC:3.4.21.45] synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] xref: EC:3.4.21.45 xref: MetaCyc:3.4.21.45-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003819 name: major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "MHC protein" EXACT [] is_obsolete: true [Term] id: GO:0003820 name: class I major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0042612 [Term] id: GO:0003821 name: class II major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0042613 [Term] id: GO:0003822 name: MHC-interacting protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544] subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003825 name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15] subset: gosubset_prok synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] synonym: "transglucosylase activity" EXACT [] synonym: "trehalose 6-phosphate synthase activity" EXACT [] synonym: "trehalose 6-phosphate synthetase activity" EXACT [] synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-phosphate synthase activity" EXACT [] synonym: "trehalose-phosphate synthetase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] xref: EC:2.4.1.15 xref: MetaCyc:TREHALOSE6PSYN-RXN xref: Reactome:REACT_27138 "Glucose is transferred from UDP-glucose onto glucose-6-phosphate, Mycobacterium tuberculosis" xref: RHEA:18892 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003826 name: alpha-ketoacid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah] subset: gosubset_prok xref: Reactome:REACT_101696 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_101855 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Plasmodium falciparum" xref: Reactome:REACT_102398 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_109062 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Canis familiaris" xref: Reactome:REACT_113399 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Mycobacterium tuberculosis" xref: Reactome:REACT_1813 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Homo sapiens" xref: Reactome:REACT_30155 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Oryza sativa" xref: Reactome:REACT_30632 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Gallus gallus" xref: Reactome:REACT_30883 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_33771 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_34024 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Bos taurus" xref: Reactome:REACT_34280 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Arabidopsis thaliana" xref: Reactome:REACT_81262 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Staphylococcus aureus N315" xref: Reactome:REACT_86541 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Sus scrofa" xref: Reactome:REACT_88849 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Mus musculus" xref: Reactome:REACT_92556 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Danio rerio" xref: Reactome:REACT_95085 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_96212 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Dictyostelium discoideum" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0003827 name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11459] synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTI" RELATED [EC:2.4.1.101] synonym: "GNTI activity" EXACT [EC:2.4.1.101] synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] xref: EC:2.4.1.101 xref: KEGG:R05983 xref: MetaCyc:2.4.1.101-RXN xref: Reactome:REACT_25236 "Addition of GlcNAc to the glycan on the A arm, Homo sapiens" xref: RHEA:11459 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003828 name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8] synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "SAT-2" RELATED [EC:2.4.99.8] xref: EC:2.4.99.8 xref: MetaCyc:2.4.99.8-RXN xref: Reactome:REACT_103372 "Polysialylation of NCAM1, Canis familiaris" xref: Reactome:REACT_103428 "Polysialylation of NCAM1, Taeniopygia guttata" xref: Reactome:REACT_104790 "Polysialylation of NCAM1, Sus scrofa" xref: Reactome:REACT_105388 "Polysialylation of NCAM1, Rattus norvegicus" xref: Reactome:REACT_110734 "Polysialylation of NCAM1, Xenopus tropicalis" xref: Reactome:REACT_18324 "Polysialylation of NCAM1, Homo sapiens" xref: Reactome:REACT_25115 "Addition of alpha-2,8-sialic acid to N-glycan over a galactose by ST8SIAs, Homo sapiens" xref: Reactome:REACT_32138 "Polysialylation of NCAM1, Danio rerio" xref: Reactome:REACT_34632 "Polysialylation of NCAM1, Gallus gallus" xref: Reactome:REACT_85065 "Polysialylation of NCAM1, Bos taurus" xref: Reactome:REACT_86310 "Polysialylation of NCAM1, Mus musculus" xref: RHEA:19316 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003829 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] xref: EC:2.4.1.102 xref: MetaCyc:2.4.1.102-RXN xref: Reactome:REACT_115554 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein, Homo sapiens" xref: Reactome:REACT_115905 "Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein, Homo sapiens" xref: RHEA:18708 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003830 name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] subset: gosubset_prok synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "GnTIII activity" EXACT [EC:2.4.1.144] synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] xref: EC:2.4.1.144 xref: MetaCyc:2.4.1.144-RXN xref: Reactome:REACT_25005 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3, Homo sapiens" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003831 name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "GalT activity" RELATED [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] xref: EC:2.4.1.38 xref: MetaCyc:2.4.1.38-RXN xref: Reactome:REACT_25178 "Addition of galactose by beta 4-galactosyltransferases, Homo sapiens" xref: RHEA:22935 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003832 name: beta-alanyl-dopamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543] synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] synonym: "NBAD hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003833 name: beta-alanyl-dopamine synthase activity namespace: molecular_function def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543] synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] synonym: "NBAD transferase activity" EXACT [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0003834 name: beta-carotene 15,15'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407] comment: Note that this function was formerly EC:1.13.11.21. synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] xref: EC:1.14.99.36 xref: KEGG:R00032 xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN xref: Reactome:REACT_25117 "Oxidation of beta-carotene to retinal, Homo sapiens" xref: RHEA:10407 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003835 name: beta-galactoside alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] xref: EC:2.4.99.1 xref: MetaCyc:2.4.99.1-RXN xref: Reactome:REACT_115891 "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position, Homo sapiens" xref: Reactome:REACT_115991 "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position, Homo sapiens" xref: Reactome:REACT_24990 "Addition of alpha-2,6-sialic acid to terminal galactose of N-glycans by ST6GAL1, Homo sapiens" xref: RHEA:11839 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003836 name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] xref: EC:2.4.99.4 xref: MetaCyc:2.4.99.4-RXN xref: Reactome:REACT_116038 "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position, Homo sapiens" xref: Reactome:REACT_25121 "Addition of alpha-2,3-sialic acid to N-glycan over a galactose by ST3GAL4, Homo sapiens" xref: RHEA:21619 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003837 name: beta-ureidopropionase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] subset: gosubset_prok synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] xref: EC:3.5.1.6 xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN xref: Reactome:REACT_101423 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Xenopus tropicalis" xref: Reactome:REACT_102071 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Danio rerio" xref: Reactome:REACT_102892 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Canis familiaris" xref: Reactome:REACT_103635 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Taeniopygia guttata" xref: Reactome:REACT_103759 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Danio rerio" xref: Reactome:REACT_104624 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Drosophila melanogaster" xref: Reactome:REACT_104670 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Taeniopygia guttata" xref: Reactome:REACT_105623 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Gallus gallus" xref: Reactome:REACT_108466 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Arabidopsis thaliana" xref: Reactome:REACT_110755 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Dictyostelium discoideum" xref: Reactome:REACT_112730 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Schizosaccharomyces pombe" xref: Reactome:REACT_115012 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Schizosaccharomyces pombe" xref: Reactome:REACT_2183 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Homo sapiens" xref: Reactome:REACT_28778 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Arabidopsis thaliana" xref: Reactome:REACT_29340 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Oryza sativa" xref: Reactome:REACT_34440 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Gallus gallus" xref: Reactome:REACT_79448 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Xenopus tropicalis" xref: Reactome:REACT_82451 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Sus scrofa" xref: Reactome:REACT_84087 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Canis familiaris" xref: Reactome:REACT_84098 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Mus musculus" xref: Reactome:REACT_84968 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Bos taurus" xref: Reactome:REACT_87205 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Drosophila melanogaster" xref: Reactome:REACT_87574 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Sus scrofa" xref: Reactome:REACT_87832 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Rattus norvegicus" xref: Reactome:REACT_902 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Homo sapiens" xref: Reactome:REACT_90983 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Caenorhabditis elegans" xref: Reactome:REACT_92584 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Dictyostelium discoideum" xref: Reactome:REACT_96079 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Bos taurus" xref: Reactome:REACT_96886 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Mus musculus" xref: Reactome:REACT_98071 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Oryza sativa" xref: Reactome:REACT_99446 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Rattus norvegicus" xref: Reactome:REACT_99655 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Caenorhabditis elegans" xref: RHEA:11187 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003838 name: sterol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] subset: gosubset_prok synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "SMT1 activity" NARROW [EC:2.1.1.41] synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] xref: EC:2.1.1.41 xref: MetaCyc:RXN3O-178 xref: RHEA:21131 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0003839 name: gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4] synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4] xref: EC:2.3.2.4 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN xref: Reactome:REACT_75867 "5-oxoproline can be formed from gamma-glutamyl-AA products, Homo sapiens" xref: Reactome:REACT_75929 "Formation of 5-oxoproline from gamma-glutamylcysteine, Homo sapiens" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003840 name: gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] subset: gosubset_prok synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN xref: Reactome:REACT_105103 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Taeniopygia guttata" xref: Reactome:REACT_107509 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Xenopus tropicalis" xref: Reactome:REACT_108503 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Escherichia coli" xref: Reactome:REACT_109920 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Oryza sativa" xref: Reactome:REACT_114722 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Caenorhabditis elegans" xref: Reactome:REACT_15356 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Homo sapiens" xref: Reactome:REACT_28900 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Saccharomyces cerevisiae" xref: Reactome:REACT_29202 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Bos taurus" xref: Reactome:REACT_75920 "Glutathione is hydrolyzed, Homo sapiens" xref: Reactome:REACT_79594 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Danio rerio" xref: Reactome:REACT_80649 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Sus scrofa" xref: Reactome:REACT_82062 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Arabidopsis thaliana" xref: Reactome:REACT_85164 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Schizosaccharomyces pombe" xref: Reactome:REACT_92059 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Canis familiaris" xref: Reactome:REACT_97168 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Mus musculus" xref: Reactome:REACT_99498 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Gallus gallus" xref: RHEA:28810 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003841 name: 1-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function alt_id: GO:0004469 def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51] subset: gosubset_prok synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "lysophosphatidate acyltransferase activity" EXACT [] synonym: "lysophosphatidic acid-acyltransferase activity" RELATED [EC:2.3.1.51] xref: EC:2.3.1.51 xref: MetaCyc:RXN-1623 xref: Reactome:REACT_100569 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Drosophila melanogaster" xref: Reactome:REACT_101159 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Bos taurus" xref: Reactome:REACT_104719 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Oryza sativa" xref: Reactome:REACT_108799 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Canis familiaris" xref: Reactome:REACT_109082 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Xenopus tropicalis" xref: Reactome:REACT_113184 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Dictyostelium discoideum" xref: Reactome:REACT_113260 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Arabidopsis thaliana" xref: Reactome:REACT_115377 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Caenorhabditis elegans" xref: Reactome:REACT_2042 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Homo sapiens" xref: Reactome:REACT_30683 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Gallus gallus" xref: Reactome:REACT_32891 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Sus scrofa" xref: Reactome:REACT_79417 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Danio rerio" xref: Reactome:REACT_81957 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Mus musculus" xref: Reactome:REACT_84904 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Taeniopygia guttata" xref: Reactome:REACT_93954 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Rattus norvegicus" xref: Reactome:REACT_93992 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Escherichia coli" xref: Reactome:REACT_96723 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Schizosaccharomyces pombe" xref: Reactome:REACT_97949 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Saccharomyces cerevisiae" xref: Reactome:REACT_99430 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Mycobacterium tuberculosis" xref: RHEA:19712 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003842 name: 1-pyrroline-5-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12] subset: gosubset_prok synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] xref: EC:1.5.1.12 xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN xref: Reactome:REACT_101154 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Gallus gallus" xref: Reactome:REACT_2180 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Homo sapiens" xref: Reactome:REACT_28267 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Bos taurus" xref: Reactome:REACT_29350 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_30746 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_32976 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Mus musculus" xref: Reactome:REACT_33427 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_77246 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_78368 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Staphylococcus aureus N315" xref: Reactome:REACT_79652 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Mycobacterium tuberculosis" xref: Reactome:REACT_82290 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_83335 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Escherichia coli" xref: Reactome:REACT_84624 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_88645 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Danio rerio" xref: Reactome:REACT_91287 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Saccharomyces cerevisiae" xref: Reactome:REACT_94154 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Canis familiaris" xref: Reactome:REACT_97859 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Schizosaccharomyces pombe" xref: RHEA:16420 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0003843 name: 1,3-beta-D-glucan synthase activity namespace: molecular_function alt_id: GO:0009981 def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003844 name: 1,4-alpha-glucan branching enzyme activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] synonym: "enzyme Q" RELATED [EC:2.4.1.18] synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] synonym: "Q-enzyme" RELATED [EC:2.4.1.18] synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] xref: EC:2.4.1.18 xref: MetaCyc:GLYCOGEN-BRANCH-RXN xref: Reactome:REACT_105148 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Danio rerio" xref: Reactome:REACT_106694 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Caenorhabditis elegans" xref: Reactome:REACT_107726 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Saccharomyces cerevisiae" xref: Reactome:REACT_115406 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Arabidopsis thaliana" xref: Reactome:REACT_1560 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Homo sapiens" xref: Reactome:REACT_30904 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Bos taurus" xref: Reactome:REACT_32069 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Taeniopygia guttata" xref: Reactome:REACT_34100 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Canis familiaris" xref: Reactome:REACT_86636 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Xenopus tropicalis" xref: Reactome:REACT_89477 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Mus musculus" xref: Reactome:REACT_89641 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Gallus gallus" xref: Reactome:REACT_94260 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Rattus norvegicus" xref: Reactome:REACT_94674 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Oryza sativa" xref: Reactome:REACT_96621 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Sus scrofa" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0003845 name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [EC:1.1.1.146, PMID:15761036] subset: gosubset_prok synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: Reactome:REACT_10043 "Oxidation of cortisol to yield cortisone, Homo sapiens" xref: Reactome:REACT_102267 "Oxidation of cortisol to yield cortisone, Canis familiaris" xref: Reactome:REACT_114165 "Oxidation of cortisol to yield cortisone, Plasmodium falciparum" xref: Reactome:REACT_31438 "Oxidation of cortisol to yield cortisone, Mus musculus" xref: Reactome:REACT_32859 "Oxidation of cortisol to yield cortisone, Dictyostelium discoideum" xref: Reactome:REACT_82916 "Oxidation of cortisol to yield cortisone, Oryza sativa" xref: Reactome:REACT_84167 "Oxidation of cortisol to yield cortisone, Xenopus tropicalis" xref: Reactome:REACT_84288 "Oxidation of cortisol to yield cortisone, Sus scrofa" xref: Reactome:REACT_86323 "Oxidation of cortisol to yield cortisone, Bos taurus" xref: Reactome:REACT_86610 "Oxidation of cortisol to yield cortisone, Arabidopsis thaliana" xref: Reactome:REACT_93487 "Oxidation of cortisol to yield cortisone, Gallus gallus" xref: Reactome:REACT_95677 "Oxidation of cortisol to yield cortisone, Taeniopygia guttata" xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003846 name: 2-acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] xref: EC:2.3.1.22 xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: RHEA:16744 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: gosubset_prok synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN xref: RHEA:17780 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: KEGG:R03503 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN xref: RHEA:11415 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0003849 name: 3-deoxy-7-phosphoheptulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720] comment: Note that this function was formerly EC:4.1.2.15. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] synonym: "DS-Co activity" RELATED [EC:2.5.1.54] synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] xref: EC:2.5.1.54 xref: KEGG:R01826 xref: MetaCyc:DAHPSYN-RXN xref: Reactome:REACT_27267 "DHAP from Ery4P and PEP, Mycobacterium tuberculosis" xref: RHEA:14720 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003850 name: 2-deoxyglucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] xref: EC:3.1.3.68 xref: KEGG:R02587 xref: MetaCyc:3.1.3.68-RXN xref: RHEA:22239 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0003851 name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] xref: EC:2.4.1.45 xref: MetaCyc:2.4.1.45-RXN xref: RHEA:10859 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003852 name: 2-isopropylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21527] comment: Note that this function was formerly EC:4.1.3.12. subset: gosubset_prok synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] xref: EC:2.3.3.13 xref: KEGG:R01213 xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN xref: RHEA:21527 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003853 name: 2-methylacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] xref: EC:1.3.99.12 xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN xref: RHEA:13264 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0003854 name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145] subset: gosubset_prok synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] xref: EC:1.1.1.145 xref: MetaCyc:1.1.1.145-RXN xref: Reactome:REACT_10031 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Homo sapiens" xref: Reactome:REACT_10067 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Homo sapiens" xref: Reactome:REACT_100839 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Danio rerio" xref: Reactome:REACT_10090 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Homo sapiens" xref: Reactome:REACT_10115 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Homo sapiens" xref: Reactome:REACT_101983 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Bos taurus" xref: Reactome:REACT_103390 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Bos taurus" xref: Reactome:REACT_103657 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Sus scrofa" xref: Reactome:REACT_103990 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Danio rerio" xref: Reactome:REACT_104422 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Drosophila melanogaster" xref: Reactome:REACT_104615 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Gallus gallus" xref: Reactome:REACT_105565 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mus musculus" xref: Reactome:REACT_106120 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Bos taurus" xref: Reactome:REACT_106214 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Danio rerio" xref: Reactome:REACT_106644 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Taeniopygia guttata" xref: Reactome:REACT_108035 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Canis familiaris" xref: Reactome:REACT_108087 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Xenopus tropicalis" xref: Reactome:REACT_108432 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Xenopus tropicalis" xref: Reactome:REACT_109510 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mus musculus" xref: Reactome:REACT_111989 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mycobacterium tuberculosis" xref: Reactome:REACT_112248 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Escherichia coli" xref: Reactome:REACT_113096 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mycobacterium tuberculosis" xref: Reactome:REACT_113257 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Escherichia coli" xref: Reactome:REACT_113772 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Escherichia coli" xref: Reactome:REACT_114424 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Escherichia coli" xref: Reactome:REACT_114777 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mycobacterium tuberculosis" xref: Reactome:REACT_114921 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mycobacterium tuberculosis" xref: Reactome:REACT_115275 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Escherichia coli" xref: Reactome:REACT_115303 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mycobacterium tuberculosis" xref: Reactome:REACT_28427 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Danio rerio" xref: Reactome:REACT_28467 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_29450 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Danio rerio" xref: Reactome:REACT_30525 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_30795 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Rattus norvegicus" xref: Reactome:REACT_30899 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Canis familiaris" xref: Reactome:REACT_32283 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Gallus gallus" xref: Reactome:REACT_32783 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mus musculus" xref: Reactome:REACT_32924 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Gallus gallus" xref: Reactome:REACT_33199 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Sus scrofa" xref: Reactome:REACT_33352 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Gallus gallus" xref: Reactome:REACT_34556 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_77900 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_78893 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_79104 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Sus scrofa" xref: Reactome:REACT_79525 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_79553 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Bos taurus" xref: Reactome:REACT_80359 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Drosophila melanogaster" xref: Reactome:REACT_80746 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Rattus norvegicus" xref: Reactome:REACT_81646 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_82293 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Sus scrofa" xref: Reactome:REACT_82688 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mus musculus" xref: Reactome:REACT_84251 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Canis familiaris" xref: Reactome:REACT_85738 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Canis familiaris" xref: Reactome:REACT_86717 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Drosophila melanogaster" xref: Reactome:REACT_87612 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Taeniopygia guttata" xref: Reactome:REACT_88118 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mus musculus" xref: Reactome:REACT_88292 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Rattus norvegicus" xref: Reactome:REACT_88643 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_91120 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Gallus gallus" xref: Reactome:REACT_93787 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Taeniopygia guttata" xref: Reactome:REACT_94450 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Xenopus tropicalis" xref: Reactome:REACT_96507 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Sus scrofa" xref: Reactome:REACT_99573 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Canis familiaris" xref: Reactome:REACT_99689 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Bos taurus" xref: Reactome:REACT_9989 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Homo sapiens" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003855 name: 3-dehydroquinate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21099] subset: gosubset_prok synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "DHQase" EXACT [EC:4.2.1.10] xref: EC:4.2.1.10 xref: KEGG:R03084 xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN xref: Reactome:REACT_27221 "Dehydratation of DHQ yields DHS, Mycobacterium tuberculosis" xref: RHEA:21099 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003856 name: 3-dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21971] subset: gosubset_prok synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4] synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "DHQ synthase" EXACT [PMID:17586643] synonym: "DHQS" EXACT [PMID:17586643] xref: EC:4.2.3.4 xref: KEGG:R03083 xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN xref: Reactome:REACT_27251 "DHQ from DAHP dephosphorylation, Mycobacterium tuberculosis" xref: RHEA:21971 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003857 name: 3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. subset: gosubset_prok synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079] synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35] synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] xref: EC:1.1.1.35 xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN xref: Reactome:REACT_100238 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_100408 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Caenorhabditis elegans" xref: Reactome:REACT_100617 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_10065 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Homo sapiens" xref: Reactome:REACT_101468 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_101506 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Xenopus tropicalis" xref: Reactome:REACT_101519 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Canis familiaris" xref: Reactome:REACT_101647 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_101913 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Gallus gallus" xref: Reactome:REACT_101921 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_102671 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_102910 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_102920 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_103002 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_103054 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_103256 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_103362 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Oryza sativa" xref: Reactome:REACT_103856 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_104004 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_104064 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_104792 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Saccharomyces cerevisiae" xref: Reactome:REACT_105101 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Arabidopsis thaliana" xref: Reactome:REACT_105286 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Escherichia coli" xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa" xref: Reactome:REACT_106598 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Caenorhabditis elegans" xref: Reactome:REACT_106630 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_106706 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_106767 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Canis familiaris" xref: Reactome:REACT_106920 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_106947 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_106969 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_106993 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Drosophila melanogaster" xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio" xref: Reactome:REACT_107618 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_107700 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_107858 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Escherichia coli" xref: Reactome:REACT_107953 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_107981 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Canis familiaris" xref: Reactome:REACT_108093 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Escherichia coli" xref: Reactome:REACT_108518 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Dictyostelium discoideum" xref: Reactome:REACT_108521 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Dictyostelium discoideum" xref: Reactome:REACT_109194 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_109636 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_109679 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Rattus norvegicus" xref: Reactome:REACT_109823 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_109984 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Arabidopsis thaliana" xref: Reactome:REACT_110388 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_110947 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_112490 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Staphylococcus aureus N315" xref: Reactome:REACT_113301 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Staphylococcus aureus N315" xref: Reactome:REACT_113705 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Staphylococcus aureus N315" xref: Reactome:REACT_115146 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Staphylococcus aureus N315" xref: Reactome:REACT_115227 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Staphylococcus aureus N315" xref: Reactome:REACT_16971 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Homo sapiens" xref: Reactome:REACT_16976 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Homo sapiens" xref: Reactome:REACT_1908 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_21320 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+, Homo sapiens" xref: Reactome:REACT_2187 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_2195 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens" xref: Reactome:REACT_242 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_28171 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Arabidopsis thaliana" xref: Reactome:REACT_28279 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_28310 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_28475 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Mus musculus" xref: Reactome:REACT_28502 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_28542 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_28734 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_28832 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Escherichia coli" xref: Reactome:REACT_28849 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Dictyostelium discoideum" xref: Reactome:REACT_29078 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_29670 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Mus musculus" xref: Reactome:REACT_29976 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Mus musculus" xref: Reactome:REACT_29995 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Oryza sativa" xref: Reactome:REACT_29997 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_30800 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_30941 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_31004 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Bos taurus" xref: Reactome:REACT_31541 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Danio rerio" xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_31990 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Sus scrofa" xref: Reactome:REACT_32500 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio" xref: Reactome:REACT_32848 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Rattus norvegicus" xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa" xref: Reactome:REACT_33370 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Drosophila melanogaster" xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_33854 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Arabidopsis thaliana" xref: Reactome:REACT_34140 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Mycobacterium tuberculosis" xref: Reactome:REACT_343 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_34604 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Oryza sativa" xref: Reactome:REACT_34731 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Escherichia coli" xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens" xref: Reactome:REACT_447 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_457 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Homo sapiens" xref: Reactome:REACT_488 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Homo sapiens" xref: Reactome:REACT_76935 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_77072 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_77100 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_77507 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_77574 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Bos taurus" xref: Reactome:REACT_78964 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_78989 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_79125 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Oryza sativa" xref: Reactome:REACT_79280 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Canis familiaris" xref: Reactome:REACT_79436 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Dictyostelium discoideum" xref: Reactome:REACT_79907 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_79918 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_80029 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_80406 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_80423 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_80985 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_81132 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Canis familiaris" xref: Reactome:REACT_81339 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Oryza sativa" xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus" xref: Reactome:REACT_81715 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_81942 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Drosophila melanogaster" xref: Reactome:REACT_82010 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Gallus gallus" xref: Reactome:REACT_82448 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Bos taurus" xref: Reactome:REACT_82560 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_82705 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_83211 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_83233 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_83339 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Arabidopsis thaliana" xref: Reactome:REACT_83343 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_83521 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Taeniopygia guttata" xref: Reactome:REACT_83685 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Dictyostelium discoideum" xref: Reactome:REACT_83929 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Oryza sativa" xref: Reactome:REACT_84012 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Drosophila melanogaster" xref: Reactome:REACT_84185 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Arabidopsis thaliana" xref: Reactome:REACT_84732 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_85076 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Danio rerio" xref: Reactome:REACT_85352 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_86008 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_86054 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Canis familiaris" xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus" xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus" xref: Reactome:REACT_86348 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Canis familiaris" xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus" xref: Reactome:REACT_87192 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Danio rerio" xref: Reactome:REACT_87443 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Canis familiaris" xref: Reactome:REACT_87448 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_87532 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Bos taurus" xref: Reactome:REACT_88318 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_88921 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Canis familiaris" xref: Reactome:REACT_89448 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Taeniopygia guttata" xref: Reactome:REACT_89623 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_89867 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_89919 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_90143 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Mus musculus" xref: Reactome:REACT_90989 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Arabidopsis thaliana" xref: Reactome:REACT_91027 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Dictyostelium discoideum" xref: Reactome:REACT_91170 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Mycobacterium tuberculosis" xref: Reactome:REACT_91389 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_91693 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Bos taurus" xref: Reactome:REACT_91746 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Gallus gallus" xref: Reactome:REACT_91758 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_92399 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_92615 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_92737 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_93233 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Danio rerio" xref: Reactome:REACT_93724 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_93920 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Canis familiaris" xref: Reactome:REACT_93932 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Danio rerio" xref: Reactome:REACT_94022 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Saccharomyces cerevisiae" xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_94192 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_94248 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Oryza sativa" xref: Reactome:REACT_94489 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Dictyostelium discoideum" xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus" xref: Reactome:REACT_95062 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Gallus gallus" xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_95512 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_95608 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_95831 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Oryza sativa" xref: Reactome:REACT_95994 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_96433 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Taeniopygia guttata" xref: Reactome:REACT_96601 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Arabidopsis thaliana" xref: Reactome:REACT_96805 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Mus musculus" xref: Reactome:REACT_96911 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_97617 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_97730 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Arabidopsis thaliana" xref: Reactome:REACT_97950 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Bos taurus" xref: Reactome:REACT_98096 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Gallus gallus" xref: Reactome:REACT_98191 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Rattus norvegicus" xref: Reactome:REACT_98235 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_98465 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Oryza sativa" xref: Reactome:REACT_98828 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_98881 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_98895 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Xenopus tropicalis" xref: Reactome:REACT_99003 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Sus scrofa" xref: Reactome:REACT_99129 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Xenopus tropicalis" xref: Reactome:REACT_99158 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Caenorhabditis elegans" xref: Reactome:REACT_99256 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_99335 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_99549 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Mus musculus" xref: Reactome:REACT_9967 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Homo sapiens" xref: Reactome:REACT_99725 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Danio rerio" xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus" xref: RHEA:22435 xref: UM-BBD_enzymeID:e0664 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003858 name: 3-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20524] subset: gosubset_prok synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] xref: EC:1.1.1.30 xref: KEGG:R01361 xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:REACT_100598 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Taeniopygia guttata" xref: Reactome:REACT_100701 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Gallus gallus" xref: Reactome:REACT_101716 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Escherichia coli" xref: Reactome:REACT_103885 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Canis familiaris" xref: Reactome:REACT_104408 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Sus scrofa" xref: Reactome:REACT_108608 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Danio rerio" xref: Reactome:REACT_110558 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Taeniopygia guttata" xref: Reactome:REACT_1493 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Homo sapiens" xref: Reactome:REACT_31121 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Bos taurus" xref: Reactome:REACT_31745 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Mus musculus" xref: Reactome:REACT_32814 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Rattus norvegicus" xref: Reactome:REACT_631 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Homo sapiens" xref: Reactome:REACT_81074 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Mus musculus" xref: Reactome:REACT_84906 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Sus scrofa" xref: Reactome:REACT_85059 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Xenopus tropicalis" xref: Reactome:REACT_87253 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Bos taurus" xref: Reactome:REACT_87733 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Gallus gallus" xref: Reactome:REACT_89789 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Escherichia coli" xref: Reactome:REACT_90360 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Xenopus tropicalis" xref: Reactome:REACT_91670 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Rattus norvegicus" xref: Reactome:REACT_95508 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Canis familiaris" xref: Reactome:REACT_97547 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Danio rerio" xref: RHEA:20524 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003859 name: 3-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17852] subset: gosubset_prok synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] synonym: "crotonase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] xref: EC:4.2.1.55 xref: KEGG:R03027 xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN xref: RHEA:17852 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003860 name: 3-hydroxyisobutyryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] subset: gosubset_prok synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] xref: EC:3.1.2.4 xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN xref: Reactome:REACT_101449 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Canis familiaris" xref: Reactome:REACT_102854 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Bos taurus" xref: Reactome:REACT_104494 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Mus musculus" xref: Reactome:REACT_106977 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Gallus gallus" xref: Reactome:REACT_107222 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Drosophila melanogaster" xref: Reactome:REACT_111014 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Taeniopygia guttata" xref: Reactome:REACT_115031 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Arabidopsis thaliana" xref: Reactome:REACT_29772 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_34277 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Plasmodium falciparum" xref: Reactome:REACT_77522 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Oryza sativa" xref: Reactome:REACT_78256 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Dictyostelium discoideum" xref: Reactome:REACT_83318 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_919 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Homo sapiens" xref: Reactome:REACT_92394 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Caenorhabditis elegans" xref: Reactome:REACT_93703 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Danio rerio" xref: Reactome:REACT_95071 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_96788 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Rattus norvegicus" xref: Reactome:REACT_97387 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Xenopus tropicalis" xref: Reactome:REACT_99747 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Sus scrofa" xref: RHEA:20891 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003861 name: 3-isopropylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003862 name: 3-isopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] synonym: "IMDH activity" EXACT [EC:1.1.1.85] synonym: "IPMDH" RELATED [EC:1.1.1.85] synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] xref: EC:1.1.1.85 xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN xref: RHEA:25082 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003863 name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] subset: gosubset_prok synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "BCKDH activity" RELATED [EC:1.2.4.4] synonym: "BCOAD activity" RELATED [EC:1.2.4.4] synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: MetaCyc:1.2.4.4-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0003864 name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] subset: gosubset_prok synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] xref: EC:2.1.2.11 xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN xref: RHEA:11827 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0003865 name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] xref: EC:1.3.99.5 xref: MetaCyc:1.3.99.5-RXN xref: Reactome:REACT_22210 "Testosterone is converted to 5-alpha-dihydroxytestosterone, Homo sapiens" is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0003866 name: 3-phosphoshikimate 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21259] subset: gosubset_prok synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] xref: EC:2.5.1.19 xref: KEGG:R03460 xref: MetaCyc:2.5.1.19-RXN xref: Reactome:REACT_27315 "EPSP from shikimate 3-phosphate, Mycobacterium tuberculosis" xref: RHEA:21259 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003867 name: 4-aminobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah] subset: gosubset_prok synonym: "4-aminobutanoate transaminase activity" EXACT [] synonym: "4-aminobutyrate aminotransferase activity" EXACT [] synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19] synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA transaminase activity" EXACT [] synonym: "GABA transferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19] xref: EC:2.6.1.19 xref: MetaCyc:GABATRANSAM-RXN xref: Reactome:REACT_23980 "Conversion of GABA to Succinate Semialdehyde, Homo sapiens" xref: RHEA:23355 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003868 name: 4-hydroxyphenylpyruvate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] subset: gosubset_prok synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] xref: EC:1.13.11.27 xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN xref: Reactome:REACT_101650 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Bos taurus" xref: Reactome:REACT_1145 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Homo sapiens" xref: Reactome:REACT_29808 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Rattus norvegicus" xref: Reactome:REACT_33537 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Mus musculus" xref: Reactome:REACT_33740 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Drosophila melanogaster" xref: Reactome:REACT_77319 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Danio rerio" xref: Reactome:REACT_77991 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Sus scrofa" xref: Reactome:REACT_81665 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Arabidopsis thaliana" xref: Reactome:REACT_85018 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Oryza sativa" xref: Reactome:REACT_86998 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Taeniopygia guttata" xref: Reactome:REACT_92448 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Canis familiaris" xref: Reactome:REACT_93903 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Gallus gallus" xref: Reactome:REACT_94777 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Xenopus tropicalis" xref: Reactome:REACT_95395 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Caenorhabditis elegans" xref: Reactome:REACT_99639 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Dictyostelium discoideum" xref: RHEA:16192 xref: UM-BBD_reactionID:r0298 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003869 name: 4-nitrophenylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [EC:3.1.3.41] subset: gosubset_prok synonym: "4-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "K-pNPPase activity" EXACT [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "NPPase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "PNPPase activity" EXACT [EC:3.1.3.41] xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: RHEA:21667 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003870 name: 5-aminolevulinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924] subset: gosubset_prok synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALAS activity" EXACT [EC:2.3.1.37] synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] xref: EC:2.3.1.37 xref: KEGG:R00830 xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN xref: Reactome:REACT_100294 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Dictyostelium discoideum" xref: Reactome:REACT_100365 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Taeniopygia guttata" xref: Reactome:REACT_101248 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Rattus norvegicus" xref: Reactome:REACT_101495 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Bos taurus" xref: Reactome:REACT_105074 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Drosophila melanogaster" xref: Reactome:REACT_106523 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Mus musculus" xref: Reactome:REACT_107818 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Canis familiaris" xref: Reactome:REACT_116003 "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2, Gallus gallus" xref: Reactome:REACT_33006 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Danio rerio" xref: Reactome:REACT_84625 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Plasmodium falciparum" xref: Reactome:REACT_86826 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Xenopus tropicalis" xref: Reactome:REACT_89048 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Sus scrofa" xref: Reactome:REACT_9463 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Homo sapiens" xref: Reactome:REACT_96967 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Saccharomyces cerevisiae" xref: Reactome:REACT_97632 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Gallus gallus" xref: Reactome:REACT_98622 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Schizosaccharomyces pombe" xref: RHEA:12924 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0003871 name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21199] subset: gosubset_prok synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] synonym: "MetE" RELATED [EC:2.1.1.14] synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] xref: EC:2.1.1.14 xref: KEGG:R04405 xref: MetaCyc:HOMOCYSMET-RXN xref: RHEA:21199 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity [Term] id: GO:0003872 name: 6-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] subset: gosubset_prok synonym: "6-phosphofructokinase reduction" EXACT [] synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "PFK" RELATED [EC:2.7.1.11] synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] xref: EC:2.7.1.11 xref: MetaCyc:6PFRUCTPHOS-RXN xref: Reactome:REACT_102109 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Taeniopygia guttata" xref: Reactome:REACT_106558 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Saccharomyces cerevisiae" xref: Reactome:REACT_107208 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Danio rerio" xref: Reactome:REACT_109655 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Mycobacterium tuberculosis" xref: Reactome:REACT_110932 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Gallus gallus" xref: Reactome:REACT_112049 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Oryza sativa" xref: Reactome:REACT_114580 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Arabidopsis thaliana" xref: Reactome:REACT_115926 "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP, Gallus gallus" xref: Reactome:REACT_31439 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Escherichia coli" xref: Reactome:REACT_32340 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Staphylococcus aureus N315" xref: Reactome:REACT_736 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Homo sapiens" xref: Reactome:REACT_77055 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Schizosaccharomyces pombe" xref: Reactome:REACT_79025 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Xenopus tropicalis" xref: Reactome:REACT_83230 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Mus musculus" xref: Reactome:REACT_84532 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Drosophila melanogaster" xref: Reactome:REACT_85052 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Canis familiaris" xref: Reactome:REACT_88450 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Sus scrofa" xref: Reactome:REACT_91497 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Rattus norvegicus" xref: Reactome:REACT_91731 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Bos taurus" xref: Reactome:REACT_96419 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Dictyostelium discoideum" xref: Reactome:REACT_97626 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Caenorhabditis elegans" xref: RHEA:16112 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003873 name: 6-phosphofructo-2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15656] synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] xref: EC:2.7.1.105 xref: KEGG:R02732 xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN xref: Reactome:REACT_104172 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Saccharomyces cerevisiae" xref: Reactome:REACT_105291 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Xenopus tropicalis" xref: Reactome:REACT_107963 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Danio rerio" xref: Reactome:REACT_115709 "fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP, Gallus gallus" xref: Reactome:REACT_28048 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Arabidopsis thaliana" xref: Reactome:REACT_29034 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Drosophila melanogaster" xref: Reactome:REACT_291 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Homo sapiens" xref: Reactome:REACT_29935 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Rattus norvegicus" xref: Reactome:REACT_31693 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Gallus gallus" xref: Reactome:REACT_33667 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Dictyostelium discoideum" xref: Reactome:REACT_34412 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Staphylococcus aureus N315" xref: Reactome:REACT_38435 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Schizosaccharomyces pombe" xref: Reactome:REACT_78095 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Sus scrofa" xref: Reactome:REACT_86368 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Bos taurus" xref: Reactome:REACT_87540 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Mus musculus" xref: Reactome:REACT_88240 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Oryza sativa" xref: Reactome:REACT_91876 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Taeniopygia guttata" xref: Reactome:REACT_98327 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Canis familiaris" xref: RHEA:15656 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003874 name: 6-pyruvoyltetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22051] subset: gosubset_prok synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] synonym: "PTPS activity" EXACT [EC:4.2.3.12] xref: EC:4.2.3.12 xref: KEGG:R04286 xref: MetaCyc:4.2.3.12-RXN xref: Reactome:REACT_111082 "DHNTP is dephosphorylated by PTPS to PTHP, Homo sapiens" xref: RHEA:22051 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003875 name: ADP-ribosylarginine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] subset: gosubset_prok synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADPribosylarginine hydrolase activity" EXACT [] synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] xref: EC:3.2.2.19 xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN xref: RHEA:20787 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003876 name: AMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase reaction" EXACT [] synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] xref: EC:3.5.4.6 xref: MetaCyc:AMP-DEAMINASE-RXN xref: Reactome:REACT_101530 "AMP + H2O => IMP + NH3 [AMPD], Oryza sativa" xref: Reactome:REACT_104690 "AMP + H2O => IMP + NH3 [AMPD], Gallus gallus" xref: Reactome:REACT_105150 "AMP + H2O => IMP + NH3 [AMPD], Saccharomyces cerevisiae" xref: Reactome:REACT_109344 "AMP + H2O => IMP + NH3 [AMPD], Plasmodium falciparum" xref: Reactome:REACT_111015 "AMP + H2O => IMP + NH3 [AMPD], Arabidopsis thaliana" xref: Reactome:REACT_64973 "AMP + H2O => IMP + NH3 [AMPD], Dictyostelium discoideum" xref: Reactome:REACT_700 "AMP + H2O => IMP + NH3 [AMPD], Homo sapiens" xref: Reactome:REACT_77256 "AMP + H2O => IMP + NH3 [AMPD], Bos taurus" xref: Reactome:REACT_79516 "AMP + H2O => IMP + NH3 [AMPD], Canis familiaris" xref: Reactome:REACT_79653 "AMP + H2O => IMP + NH3 [AMPD], Xenopus tropicalis" xref: Reactome:REACT_81794 "AMP + H2O => IMP + NH3 [AMPD], Caenorhabditis elegans" xref: Reactome:REACT_83409 "AMP + H2O => IMP + NH3 [AMPD], Sus scrofa" xref: Reactome:REACT_87577 "AMP + H2O => IMP + NH3 [AMPD], Taeniopygia guttata" xref: Reactome:REACT_95231 "AMP + H2O => IMP + NH3 [AMPD], Mus musculus" xref: Reactome:REACT_98379 "AMP + H2O => IMP + NH3 [AMPD], Danio rerio" xref: Reactome:REACT_98734 "AMP + H2O => IMP + NH3 [AMPD], Rattus norvegicus" xref: Reactome:REACT_99903 "AMP + H2O => IMP + NH3 [AMPD], Drosophila melanogaster" xref: RHEA:14780 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0003877 name: ATP adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] subset: gosubset_prok synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] synonym: "ADP:ATP adenylyltransferase activity" EXACT [] synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] xref: EC:2.7.7.53 xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN xref: RHEA:16580 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003878 name: ATP citrate synthase activity namespace: molecular_function alt_id: GO:0046913 def: "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163] comment: Note that this function was formerly EC:4.1.3.8. synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] xref: EC:2.3.3.8 xref: KEGG:R00352 xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN xref: MetaCyc:PWY-5172 xref: Reactome:REACT_103402 "Generation of Cytoplasmic Acetyl CoA from Citrate, Arabidopsis thaliana" xref: Reactome:REACT_105575 "Generation of Cytoplasmic Acetyl CoA from Citrate, Drosophila melanogaster" xref: Reactome:REACT_1141 "Generation of Cytoplasmic Acetyl CoA from Citrate, Homo sapiens" xref: Reactome:REACT_114344 "Generation of Cytoplasmic Acetyl CoA from Citrate, Saccharomyces cerevisiae" xref: Reactome:REACT_114419 "Generation of Cytoplasmic Acetyl CoA from Citrate, Caenorhabditis elegans" xref: Reactome:REACT_29907 "Generation of Cytoplasmic Acetyl CoA from Citrate, Danio rerio" xref: Reactome:REACT_31411 "Generation of Cytoplasmic Acetyl CoA from Citrate, Oryza sativa" xref: Reactome:REACT_34626 "Generation of Cytoplasmic Acetyl CoA from Citrate, Xenopus tropicalis" xref: Reactome:REACT_34711 "Generation of Cytoplasmic Acetyl CoA from Citrate, Mus musculus" xref: Reactome:REACT_78048 "Generation of Cytoplasmic Acetyl CoA from Citrate, Schizosaccharomyces pombe" xref: Reactome:REACT_78150 "Generation of Cytoplasmic Acetyl CoA from Citrate, Sus scrofa" xref: Reactome:REACT_83858 "Generation of Cytoplasmic Acetyl CoA from Citrate, Canis familiaris" xref: Reactome:REACT_86684 "Generation of Cytoplasmic Acetyl CoA from Citrate, Gallus gallus" xref: Reactome:REACT_90155 "Generation of Cytoplasmic Acetyl CoA from Citrate, Rattus norvegicus" xref: Reactome:REACT_92200 "Generation of Cytoplasmic Acetyl CoA from Citrate, Dictyostelium discoideum" xref: Reactome:REACT_93895 "Generation of Cytoplasmic Acetyl CoA from Citrate, Bos taurus" xref: Reactome:REACT_99638 "Generation of Cytoplasmic Acetyl CoA from Citrate, Taeniopygia guttata" xref: RHEA:21163 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003879 name: ATP phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] xref: EC:2.4.2.17 xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN xref: RHEA:18476 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003880 name: protein C-terminal carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937] subset: gosubset_prok synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0003881 name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11583] subset: gosubset_prok synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "phosphatidylinositol synthase activity" EXACT [] xref: EC:2.7.8.11 xref: KEGG:R01802 xref: MetaCyc:2.7.8.11-RXN xref: RHEA:11583 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003882 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] subset: gosubset_prok synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: MetaCyc:PHOSPHASERSYN-RXN xref: RHEA:16916 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003883 name: CTP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] subset: gosubset_prok synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] xref: EC:6.3.4.2 xref: MetaCyc:CTPSYN-RXN xref: Reactome:REACT_101507 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Rattus norvegicus" xref: Reactome:REACT_102614 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Xenopus tropicalis" xref: Reactome:REACT_102874 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Saccharomyces cerevisiae" xref: Reactome:REACT_105827 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Schizosaccharomyces pombe" xref: Reactome:REACT_108024 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Plasmodium falciparum" xref: Reactome:REACT_109286 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Arabidopsis thaliana" xref: Reactome:REACT_109358 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Gallus gallus" xref: Reactome:REACT_110148 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Taeniopygia guttata" xref: Reactome:REACT_21305 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Homo sapiens" xref: Reactome:REACT_28893 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Drosophila melanogaster" xref: Reactome:REACT_29290 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Sus scrofa" xref: Reactome:REACT_32806 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Taeniopygia guttata" xref: Reactome:REACT_33151 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Saccharomyces cerevisiae" xref: Reactome:REACT_34398 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Dictyostelium discoideum" xref: Reactome:REACT_574 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Homo sapiens" xref: Reactome:REACT_77809 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Plasmodium falciparum" xref: Reactome:REACT_78348 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Mus musculus" xref: Reactome:REACT_79156 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Schizosaccharomyces pombe" xref: Reactome:REACT_79789 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Bos taurus" xref: Reactome:REACT_81861 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Canis familiaris" xref: Reactome:REACT_82397 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Oryza sativa" xref: Reactome:REACT_83666 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Mus musculus" xref: Reactome:REACT_83762 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Oryza sativa" xref: Reactome:REACT_85039 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Dictyostelium discoideum" xref: Reactome:REACT_85189 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Caenorhabditis elegans" xref: Reactome:REACT_89739 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Canis familiaris" xref: Reactome:REACT_89978 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Xenopus tropicalis" xref: Reactome:REACT_91233 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Gallus gallus" xref: Reactome:REACT_93144 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Drosophila melanogaster" xref: Reactome:REACT_93220 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Arabidopsis thaliana" xref: Reactome:REACT_96180 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Danio rerio" xref: Reactome:REACT_96817 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Rattus norvegicus" xref: Reactome:REACT_98673 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Bos taurus" xref: Reactome:REACT_98846 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Sus scrofa" xref: Reactome:REACT_99502 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Caenorhabditis elegans" xref: RHEA:16600 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003884 name: D-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3] subset: gosubset_prok synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] xref: EC:1.4.3.3 xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN xref: Reactome:REACT_106309 "glycine + O2 => glyoxylate + H2O2 + NH4+, Mus musculus" xref: Reactome:REACT_113962 "glycine + O2 => glyoxylate + H2O2 + NH4+, Schizosaccharomyces pombe" xref: Reactome:REACT_114219 "glycine + O2 => glyoxylate + H2O2 + NH4+, Drosophila melanogaster" xref: Reactome:REACT_115360 "glycine + O2 => glyoxylate + H2O2 + NH4+, Mycobacterium tuberculosis" xref: Reactome:REACT_115482 "glycine + O2 => glyoxylate + H2O2 + NH4+, Caenorhabditis elegans" xref: Reactome:REACT_17049 "glycine + O2 => glyoxylate + H2O2 + NH4+, Homo sapiens" xref: Reactome:REACT_31469 "glycine + O2 => glyoxylate + H2O2 + NH4+, Gallus gallus" xref: Reactome:REACT_34652 "glycine + O2 => glyoxylate + H2O2 + NH4+, Danio rerio" xref: Reactome:REACT_77556 "glycine + O2 => glyoxylate + H2O2 + NH4+, Bos taurus" xref: Reactome:REACT_77723 "glycine + O2 => glyoxylate + H2O2 + NH4+, Taeniopygia guttata" xref: Reactome:REACT_88459 "glycine + O2 => glyoxylate + H2O2 + NH4+, Canis familiaris" xref: Reactome:REACT_88556 "glycine + O2 => glyoxylate + H2O2 + NH4+, Rattus norvegicus" xref: Reactome:REACT_88963 "glycine + O2 => glyoxylate + H2O2 + NH4+, Sus scrofa" xref: Reactome:REACT_93508 "glycine + O2 => glyoxylate + H2O2 + NH4+, Xenopus tropicalis" xref: Reactome:REACT_93867 "glycine + O2 => glyoxylate + H2O2 + NH4+, Dictyostelium discoideum" xref: RHEA:21819 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0003885 name: D-arabinono-1,4-lactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23759] subset: gosubset_prok synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] xref: EC:1.1.3.37 xref: KEGG:R02715 xref: MetaCyc:1.1.3.37-RXN xref: RHEA:23759 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003886 name: DNA (cytosine-5-)-methyltransferase activity namespace: molecular_function alt_id: GO:0008326 def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). subset: gosubset_prok synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] synonym: "modification methylase activity" RELATED [EC:2.1.1.37] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: MetaCyc:2.1.1.73-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0003887 name: DNA-directed DNA polymerase activity namespace: molecular_function alt_id: GO:0003888 alt_id: GO:0003889 alt_id: GO:0003890 alt_id: GO:0003891 alt_id: GO:0003893 alt_id: GO:0003894 alt_id: GO:0003895 alt_id: GO:0008723 alt_id: GO:0015999 alt_id: GO:0016000 alt_id: GO:0016448 alt_id: GO:0016449 alt_id: GO:0016450 alt_id: GO:0016451 alt_id: GO:0016452 alt_id: GO:0019984 def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684] subset: gosubset_prok synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.7 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:REACT_101168 "Misinsertion of bases opposite to the lesion by HREV1, Drosophila melanogaster" xref: Reactome:REACT_101456 "Elongation by HREV1 protein, Arabidopsis thaliana" xref: Reactome:REACT_101578 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Schizosaccharomyces pombe" xref: Reactome:REACT_102164 "DNA strand displacement synthesis, Arabidopsis thaliana" xref: Reactome:REACT_1024 "Formation of Okazaki fragments, Homo sapiens" xref: Reactome:REACT_102850 "Elongation by Pol eta, Sus scrofa" xref: Reactome:REACT_102905 "Resynthesis of excised residue, Mus musculus" xref: Reactome:REACT_103072 "POL Beta mediated incorporation of the first replacement nucleotide, Taeniopygia guttata" xref: Reactome:REACT_103285 "Elongation by Pol zeta complex, Sus scrofa" xref: Reactome:REACT_103439 "Misinsertion of bases opposite to the lesion by HREV1, Taeniopygia guttata" xref: Reactome:REACT_103520 "Elongation by Pol zeta complex, Mus musculus" xref: Reactome:REACT_103531 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Arabidopsis thaliana" xref: Reactome:REACT_104153 "Formation of Okazaki fragments, Arabidopsis thaliana" xref: Reactome:REACT_104851 "Elongation by HREV1 protein, Drosophila melanogaster" xref: Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_104973 "Elongation by Pol eta, Arabidopsis thaliana" xref: Reactome:REACT_105070 "Insertion of correct bases opposite to the lesion by Pol eta, Saccharomyces cerevisiae" xref: Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa" xref: Reactome:REACT_105659 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Danio rerio" xref: Reactome:REACT_105733 "Elongation by HREV1 protein, Canis familiaris" xref: Reactome:REACT_105794 "Insertion of correct bases opposite to the lesion by Pol eta, Arabidopsis thaliana" xref: Reactome:REACT_105961 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Bos taurus" xref: Reactome:REACT_106002 "Resynthesis of excised residue, Rattus norvegicus" xref: Reactome:REACT_106057 "Insertion of correct bases opposite to the lesion by Pol eta, Drosophila melanogaster" xref: Reactome:REACT_106334 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Canis familiaris" xref: Reactome:REACT_106776 "Elongation by HREV1 protein, Caenorhabditis elegans" xref: Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe" xref: Reactome:REACT_107125 "Elongation by HREV1 protein, Rattus norvegicus" xref: Reactome:REACT_107358 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Danio rerio" xref: Reactome:REACT_107480 "Elongation by HREV1 protein, Schizosaccharomyces pombe" xref: Reactome:REACT_107781 "Misinsertion of bases opposite to the lesion by HREV1, Rattus norvegicus" xref: Reactome:REACT_107879 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Canis familiaris" xref: Reactome:REACT_107930 "Formation of Okazaki fragments, Mus musculus" xref: Reactome:REACT_108241 "Elongation by HREV1 protein, Xenopus tropicalis" xref: Reactome:REACT_108640 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Drosophila melanogaster" xref: Reactome:REACT_108802 "Elongation by Pol eta, Rattus norvegicus" xref: Reactome:REACT_109069 "Formation of Okazaki fragments, Oryza sativa" xref: Reactome:REACT_109329 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Bos taurus" xref: Reactome:REACT_109542 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus" xref: Reactome:REACT_109749 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Rattus norvegicus" xref: Reactome:REACT_109858 "Insertion of correct bases opposite to the lesion by Pol eta, Bos taurus" xref: Reactome:REACT_109873 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_109947 "Misinsertion of bases opposite to the lesion by HREV1, Xenopus tropicalis" xref: Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris" xref: Reactome:REACT_112231 "Elongation by Pol zeta complex, Xenopus tropicalis" xref: Reactome:REACT_112289 "Elongation by Pol zeta complex, Taeniopygia guttata" xref: Reactome:REACT_112468 "Elongation by Pol zeta complex, Dictyostelium discoideum" xref: Reactome:REACT_1196 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Homo sapiens" xref: Reactome:REACT_1324 "Elongation by Pol zeta complex, Homo sapiens" xref: Reactome:REACT_1479 "Elongation by Pol eta, Homo sapiens" xref: Reactome:REACT_2016 "Insertion of correct bases opposite to the lesion by Pol eta, Homo sapiens" xref: Reactome:REACT_2214 "Misinsertion of bases opposite to the lesion by HREV1, Homo sapiens" xref: Reactome:REACT_2224 "POL Beta mediated incorporation of the first replacement nucleotide, Homo sapiens" xref: Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_28619 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Rattus norvegicus" xref: Reactome:REACT_28865 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Dictyostelium discoideum" xref: Reactome:REACT_29011 "Elongation by Pol zeta complex, Gallus gallus" xref: Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio" xref: Reactome:REACT_292 "Resynthesis of excised residue, Homo sapiens" xref: Reactome:REACT_29783 "Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus" xref: Reactome:REACT_31346 "Elongation by Pol eta, Drosophila melanogaster" xref: Reactome:REACT_31460 "Misinsertion of bases opposite to the lesion by HREV1, Oryza sativa" xref: Reactome:REACT_31614 "POL Beta mediated incorporation of the first replacement nucleotide, Danio rerio" xref: Reactome:REACT_31809 "POL Beta mediated incorporation of the first replacement nucleotide, Mus musculus" xref: Reactome:REACT_32473 "Elongation by Pol eta, Gallus gallus" xref: Reactome:REACT_32478 "Formation of Okazaki fragments, Xenopus tropicalis" xref: Reactome:REACT_32689 "Misinsertion of bases opposite to the lesion by HREV1, Gallus gallus" xref: Reactome:REACT_32853 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Canis familiaris" xref: Reactome:REACT_33072 "Insertion of correct bases opposite to the lesion by Pol eta, Taeniopygia guttata" xref: Reactome:REACT_33294 "Insertion of correct bases opposite to the lesion by Pol eta, Sus scrofa" xref: Reactome:REACT_33524 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Canis familiaris" xref: Reactome:REACT_34369 "Elongation by Pol eta, Caenorhabditis elegans" xref: Reactome:REACT_34392 "Misinsertion of bases opposite to the lesion by HREV1, Sus scrofa" xref: Reactome:REACT_34531 "DNA strand displacement synthesis, Danio rerio" xref: Reactome:REACT_353 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Homo sapiens" xref: Reactome:REACT_36881 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Canis familiaris" xref: Reactome:REACT_41 "DNA strand displacement synthesis, Homo sapiens" xref: Reactome:REACT_465 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Homo sapiens" xref: Reactome:REACT_54850 "POL Beta mediated incorporation of the first replacement nucleotide, Canis familiaris" xref: Reactome:REACT_677 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Homo sapiens" xref: Reactome:REACT_68438 "Formation of Okazaki fragments, Schizosaccharomyces pombe" xref: Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa" xref: Reactome:REACT_77463 "Misinsertion of bases opposite to the lesion by HREV1, Caenorhabditis elegans" xref: Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_78145 "Resynthesis of excised residue, Canis familiaris" xref: Reactome:REACT_78146 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Taeniopygia guttata" xref: Reactome:REACT_78405 "Formation of Okazaki fragments, Danio rerio" xref: Reactome:REACT_78413 "Misinsertion of bases opposite to the lesion by HREV1, Schizosaccharomyces pombe" xref: Reactome:REACT_78425 "DNA strand displacement synthesis, Xenopus tropicalis" xref: Reactome:REACT_78678 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Mus musculus" xref: Reactome:REACT_78735 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Gallus gallus" xref: Reactome:REACT_78796 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Caenorhabditis elegans" xref: Reactome:REACT_79308 "Elongation by Pol eta, Taeniopygia guttata" xref: Reactome:REACT_79568 "Elongation by HREV1 protein, Mycobacterium tuberculosis" xref: Reactome:REACT_79756 "Resynthesis of excised residue, Bos taurus" xref: Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_80037 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Danio rerio" xref: Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Homo sapiens" xref: Reactome:REACT_80054 "Elongation by Pol eta, Bos taurus" xref: Reactome:REACT_80171 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Taeniopygia guttata" xref: Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens" xref: Reactome:REACT_80471 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Mus musculus" xref: Reactome:REACT_80487 "Elongation by Pol eta, Schizosaccharomyces pombe" xref: Reactome:REACT_80495 "Insertion of correct bases opposite to the lesion by Pol eta, Mus musculus" xref: Reactome:REACT_80499 "Elongation by Pol eta, Mycobacterium tuberculosis" xref: Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_80712 "Misinsertion of bases opposite to the lesion by HREV1, Mus musculus" xref: Reactome:REACT_80802 "Resynthesis of excised residue, Dictyostelium discoideum" xref: Reactome:REACT_81020 "Insertion of correct bases opposite to the lesion by Pol eta, Caenorhabditis elegans" xref: Reactome:REACT_81188 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Gallus gallus" xref: Reactome:REACT_81625 "DNA strand displacement synthesis, Oryza sativa" xref: Reactome:REACT_81807 "Insertion of correct bases opposite to the lesion by Pol eta, Mycobacterium tuberculosis" xref: Reactome:REACT_81927 "Resynthesis of excised residue, Danio rerio" xref: Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Sus scrofa" xref: Reactome:REACT_82001 "Misinsertion of bases opposite to the lesion by HREV1, Arabidopsis thaliana" xref: Reactome:REACT_82035 "Misinsertion of bases opposite to the lesion by HREV1, Canis familiaris" xref: Reactome:REACT_82077 "Insertion of correct bases opposite to the lesion by Pol eta, Danio rerio" xref: Reactome:REACT_82208 "Elongation by HREV1 protein, Sus scrofa" xref: Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_82557 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Mus musculus" xref: Reactome:REACT_82934 "Elongation by Pol zeta complex, Rattus norvegicus" xref: Reactome:REACT_83390 "Elongation by HREV1 protein, Gallus gallus" xref: Reactome:REACT_83447 "Elongation by Pol zeta complex, Canis familiaris" xref: Reactome:REACT_83674 "Elongation by Pol eta, Saccharomyces cerevisiae" xref: Reactome:REACT_83763 "Elongation by Pol eta, Mus musculus" xref: Reactome:REACT_83918 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Sus scrofa" xref: Reactome:REACT_84028 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Rattus norvegicus" xref: Reactome:REACT_84123 "DNA strand displacement synthesis, Mus musculus" xref: Reactome:REACT_84407 "Elongation by HREV1 protein, Saccharomyces cerevisiae" xref: Reactome:REACT_84633 "Formation of Okazaki fragments, Canis familiaris" xref: Reactome:REACT_84853 "Misinsertion of bases opposite to the lesion by HREV1, Danio rerio" xref: Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Mus musculus" xref: Reactome:REACT_85325 "Formation of Okazaki fragments, Bos taurus" xref: Reactome:REACT_85611 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Saccharomyces cerevisiae" xref: Reactome:REACT_86134 "Insertion of correct bases opposite to the lesion by Pol eta, Schizosaccharomyces pombe" xref: Reactome:REACT_86652 "Elongation by HREV1 protein, Mus musculus" xref: Reactome:REACT_867 "Elongation by HREV1 protein, Homo sapiens" xref: Reactome:REACT_86753 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Xenopus tropicalis" xref: Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_87439 "DNA strand displacement synthesis, Bos taurus" xref: Reactome:REACT_87801 "Misinsertion of bases opposite to the lesion by HREV1, Mycobacterium tuberculosis" xref: Reactome:REACT_88067 "Elongation by Pol zeta complex, Bos taurus" xref: Reactome:REACT_88473 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Oryza sativa" xref: Reactome:REACT_88663 "Insertion of correct bases opposite to the lesion by Pol eta, Oryza sativa" xref: Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Danio rerio" xref: Reactome:REACT_88997 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Plasmodium falciparum" xref: Reactome:REACT_89118 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Mus musculus" xref: Reactome:REACT_89129 "DNA strand displacement synthesis, Canis familiaris" xref: Reactome:REACT_89399 "Formation of Okazaki fragments, Rattus norvegicus" xref: Reactome:REACT_89782 "POL Beta mediated incorporation of the first replacement nucleotide, Rattus norvegicus" xref: Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus" xref: Reactome:REACT_8992 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand, Homo sapiens" xref: Reactome:REACT_90310 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Xenopus tropicalis" xref: Reactome:REACT_90511 "Misinsertion of bases opposite to the lesion by HREV1, Saccharomyces cerevisiae" xref: Reactome:REACT_90564 "DNA strand displacement synthesis, Sus scrofa" xref: Reactome:REACT_90691 "Insertion of correct bases opposite to the lesion by Pol eta, Canis familiaris" xref: Reactome:REACT_9075 "3' PPT-primed initiation of plus-strand DNA synthesis, Homo sapiens" xref: Reactome:REACT_91 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Homo sapiens" xref: Reactome:REACT_91123 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Danio rerio" xref: Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Oryza sativa" xref: Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus" xref: Reactome:REACT_91536 "Elongation by Pol eta, Oryza sativa" xref: Reactome:REACT_91619 "Elongation by Pol eta, Canis familiaris" xref: Reactome:REACT_91873 "POL Beta mediated incorporation of the first replacement nucleotide, Xenopus tropicalis" xref: Reactome:REACT_91890 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Rattus norvegicus" xref: Reactome:REACT_92243 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Rattus norvegicus" xref: Reactome:REACT_92358 "POL Beta mediated incorporation of the first replacement nucleotide, Sus scrofa" xref: Reactome:REACT_92410 "POL Beta mediated incorporation of the first replacement nucleotide, Dictyostelium discoideum" xref: Reactome:REACT_92575 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Bos taurus" xref: Reactome:REACT_92627 "Elongation by Pol eta, Danio rerio" xref: Reactome:REACT_92680 "Elongation by Pol zeta complex, Arabidopsis thaliana" xref: Reactome:REACT_93171 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Mus musculus" xref: Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana" xref: Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Canis familiaris" xref: Reactome:REACT_94081 "Elongation by Pol zeta complex, Drosophila melanogaster" xref: Reactome:REACT_94622 "POL Beta mediated incorporation of the first replacement nucleotide, Bos taurus" xref: Reactome:REACT_95001 "Formation of Okazaki fragments, Sus scrofa" xref: Reactome:REACT_95443 "DNA strand displacement synthesis, Rattus norvegicus" xref: Reactome:REACT_95853 "Resynthesis of excised residue, Xenopus tropicalis" xref: Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_96549 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Bos taurus" xref: Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Bos taurus" xref: Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis" xref: Reactome:REACT_97598 "Elongation by Pol zeta complex, Schizosaccharomyces pombe" xref: Reactome:REACT_97861 "Elongation by HREV1 protein, Taeniopygia guttata" xref: Reactome:REACT_97874 "Elongation by HREV1 protein, Oryza sativa" xref: Reactome:REACT_97969 "Insertion of correct bases opposite to the lesion by Pol eta, Rattus norvegicus" xref: Reactome:REACT_97975 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Danio rerio" xref: Reactome:REACT_98393 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Bos taurus" xref: Reactome:REACT_98499 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Xenopus tropicalis" xref: Reactome:REACT_98529 "Elongation by HREV1 protein, Danio rerio" xref: Reactome:REACT_99265 "Elongation by Pol zeta complex, Danio rerio" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003892 name: proliferating cell nuclear antigen namespace: molecular_function alt_id: GO:0005661 def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "PCNA" EXACT [] is_obsolete: true [Term] id: GO:0003896 name: DNA primase activity namespace: molecular_function alt_id: GO:0003897 alt_id: GO:0003898 def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0003899 name: DNA-directed RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:REACT_100344 "Addition of Nucleotides 5 through 9 on the growing Transcript, Drosophila melanogaster" xref: Reactome:REACT_100410 "Addition of nucleotides between position +11 and +30, Bos taurus" xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae" xref: Reactome:REACT_101858 "Elongation of pre-rRNA transcript, Taeniopygia guttata" xref: Reactome:REACT_101953 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Oryza sativa" xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis" xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus" xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus" xref: Reactome:REACT_102466 "Addition of nucleotides between position +11 and +30, Rattus norvegicus" xref: Reactome:REACT_102706 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Rattus norvegicus" xref: Reactome:REACT_102769 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Schizosaccharomyces pombe" xref: Reactome:REACT_102802 "Pol II mediated transcription of microRNA genes, Saccharomyces cerevisiae" xref: Reactome:REACT_102951 "Elongation of pre-rRNA transcript, Drosophila melanogaster" xref: Reactome:REACT_103006 "Elongation of pre-rRNA transcript, Rattus norvegicus" xref: Reactome:REACT_103501 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_103871 "Addition of nucleotides between position +11 and +30, Gallus gallus" xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus" xref: Reactome:REACT_104171 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Danio rerio" xref: Reactome:REACT_104334 "Addition of nucleotides between position +11 and +30, Canis familiaris" xref: Reactome:REACT_104618 "Pol II mediated transcription of microRNA genes, Oryza sativa" xref: Reactome:REACT_105022 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Drosophila melanogaster" xref: Reactome:REACT_105177 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Mus musculus" xref: Reactome:REACT_105539 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Gallus gallus" xref: Reactome:REACT_105890 "Pol II mediated transcription of microRNA genes, Taeniopygia guttata" xref: Reactome:REACT_106497 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Plasmodium falciparum" xref: Reactome:REACT_106762 "Addition of Nucleotides 5 through 9 on the growing Transcript, Mus musculus" xref: Reactome:REACT_106790 "Addition of Nucleotides 5 through 9 on the growing Transcript, Danio rerio" xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum" xref: Reactome:REACT_1082 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Homo sapiens" xref: Reactome:REACT_108279 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_108323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana" xref: Reactome:REACT_109090 "Addition of nucleotides between position +11 and +30, Saccharomyces cerevisiae" xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana" xref: Reactome:REACT_110305 "Pol II mediated transcription of microRNA genes, Danio rerio" xref: Reactome:REACT_110458 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Canis familiaris" xref: Reactome:REACT_110741 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_112737 "Addition of Nucleotides 5 through 9 on the growing Transcript, Gallus gallus" xref: Reactome:REACT_112968 "Elongation of pre-rRNA transcript, Oryza sativa" xref: Reactome:REACT_113943 "Elongation of pre-rRNA transcript, Gallus gallus" xref: Reactome:REACT_12505 "Pol II mediated transcription of microRNA genes, Homo sapiens" xref: Reactome:REACT_1611 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Homo sapiens" xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_209 "Addition of nucleotides between position +11 and +30, Homo sapiens" xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster" xref: Reactome:REACT_28303 "Addition of nucleotides between position +11 and +30, Arabidopsis thaliana" xref: Reactome:REACT_28467 "Pol II mediated transcription of microRNA genes, Caenorhabditis elegans" xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa" xref: Reactome:REACT_28970 "Addition of nucleotides between position +11 and +30, Oryza sativa" xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster" xref: Reactome:REACT_29681 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Oryza sativa" xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa" xref: Reactome:REACT_30335 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Caenorhabditis elegans" xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_31831 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Caenorhabditis elegans" xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans" xref: Reactome:REACT_32905 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Arabidopsis thaliana" xref: Reactome:REACT_34518 "Elongation of pre-rRNA transcript, Sus scrofa" xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens" xref: Reactome:REACT_581 "Addition of Nucleotides 5 through 9 on the growing Transcript, Homo sapiens" xref: Reactome:REACT_6172 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_6208 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition, Homo sapiens" xref: Reactome:REACT_6240 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_77161 "Pol II mediated transcription of microRNA genes, Gallus gallus" xref: Reactome:REACT_77417 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Danio rerio" xref: Reactome:REACT_77879 "Addition of nucleotides between position +11 and +30, Drosophila melanogaster" xref: Reactome:REACT_78158 "Elongation of pre-rRNA transcript, Bos taurus" xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus" xref: Reactome:REACT_7998 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Homo sapiens" xref: Reactome:REACT_80162 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Xenopus tropicalis" xref: Reactome:REACT_80268 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Danio rerio" xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio" xref: Reactome:REACT_80396 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Mus musculus" xref: Reactome:REACT_80464 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Dictyostelium discoideum" xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus" xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus" xref: Reactome:REACT_80768 "Elongation of pre-rRNA transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_80999 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_81250 "Elongation of pre-rRNA transcript, Canis familiaris" xref: Reactome:REACT_81257 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_82798 "Addition of nucleotides between position +11 and +30, Schizosaccharomyces pombe" xref: Reactome:REACT_83185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Canis familiaris" xref: Reactome:REACT_83805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_84137 "Pol II mediated transcription of microRNA genes, Plasmodium falciparum" xref: Reactome:REACT_84172 "Pol II mediated transcription of microRNA genes, Xenopus tropicalis" xref: Reactome:REACT_85303 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_85444 "Pol II mediated transcription of microRNA genes, Bos taurus" xref: Reactome:REACT_86290 "Elongation of pre-rRNA transcript, Mus musculus" xref: Reactome:REACT_86701 "Pol II mediated transcription of microRNA genes, Dictyostelium discoideum" xref: Reactome:REACT_86831 "Elongation of pre-rRNA transcript, Xenopus tropicalis" xref: Reactome:REACT_87150 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Rattus norvegicus" xref: Reactome:REACT_872 "Elongation of pre-rRNA transcript, Homo sapiens" xref: Reactome:REACT_87708 "Addition of nucleotides between position +11 and +30, Mus musculus" xref: Reactome:REACT_88237 "Addition of nucleotides between position +11 and +30, Xenopus tropicalis" xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans" xref: Reactome:REACT_88577 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Arabidopsis thaliana" xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis" xref: Reactome:REACT_89527 "Addition of Nucleotides 5 through 9 on the growing Transcript, Rattus norvegicus" xref: Reactome:REACT_89539 "Pol II mediated transcription of microRNA genes, Arabidopsis thaliana" xref: Reactome:REACT_90076 "Addition of nucleotides between position +11 and +30, Caenorhabditis elegans" xref: Reactome:REACT_90432 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_90456 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Xenopus tropicalis" xref: Reactome:REACT_91185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Bos taurus" xref: Reactome:REACT_91186 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Drosophila melanogaster" xref: Reactome:REACT_91701 "Pol II mediated transcription of microRNA genes, Drosophila melanogaster" xref: Reactome:REACT_91945 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Saccharomyces cerevisiae" xref: Reactome:REACT_93006 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Bos taurus" xref: Reactome:REACT_93214 "Addition of Nucleotides 5 through 9 on the growing Transcript, Xenopus tropicalis" xref: Reactome:REACT_93674 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_94323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Canis familiaris" xref: Reactome:REACT_95240 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_95273 "Pol II mediated transcription of microRNA genes, Canis familiaris" xref: Reactome:REACT_95718 "Pol II mediated transcription of microRNA genes, Rattus norvegicus" xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_96380 "Addition of nucleotides between position +11 and +30, Danio rerio" xref: Reactome:REACT_97333 "Pol II mediated transcription of microRNA genes, Schizosaccharomyces pombe" xref: Reactome:REACT_97557 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Bos taurus" xref: Reactome:REACT_97977 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Mus musculus" xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum" xref: Reactome:REACT_98842 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Dictyostelium discoideum" xref: Reactome:REACT_98844 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Oryza sativa" xref: Reactome:REACT_98898 "Pol II mediated transcription of microRNA genes, Mus musculus" xref: Reactome:REACT_99037 "Elongation of pre-rRNA transcript, Caenorhabditis elegans" xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio" xref: Reactome:REACT_99215 "Addition of nucleotides between position +11 and +30, Dictyostelium discoideum" xref: Reactome:REACT_99300 "Addition of Nucleotides 5 through 9 on the growing Transcript, Bos taurus" xref: Reactome:REACT_99424 "Elongation of pre-rRNA transcript, Danio rerio" is_a: GO:0034062 ! RNA polymerase activity [Term] id: GO:0003900 name: DNA-directed RNA polymerase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003901 name: DNA-directed RNA polymerase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003902 name: DNA-directed RNA polymerase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003904 name: deoxyribodipyrimidine photo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3] subset: gosubset_prok synonym: "CPD photolyase activity" EXACT [PMID:16302973] synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] synonym: "photolyase activity" EXACT [EC:4.1.99.3] synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] synonym: "PRE" RELATED [EC:4.1.99.3] xref: EC:4.1.99.3 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003905 name: alkylbase DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0004036 def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0003906 name: DNA-(apurinic or apyrimidinic site) lyase activity namespace: molecular_function def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] subset: gosubset_prok synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18] synonym: "AP lyase activity" EXACT [EC:4.2.99.18] synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18] synonym: "E. coli endonuclease III activity" NARROW [EC:4.2.99.18] synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "endonuclease VIII activity" RELATED [] synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18] synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18] synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18] xref: EC:4.2.99.18 xref: MetaCyc:4.2.99.18-RXN xref: Reactome:REACT_103252 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Xenopus tropicalis" xref: Reactome:REACT_1215 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Homo sapiens" xref: Reactome:REACT_32396 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Rattus norvegicus" xref: Reactome:REACT_55273 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Dictyostelium discoideum" xref: Reactome:REACT_79844 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Mus musculus" xref: Reactome:REACT_83849 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Danio rerio" xref: Reactome:REACT_85754 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Sus scrofa" xref: Reactome:REACT_96683 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Bos taurus" xref: Reactome:REACT_97368 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Canis familiaris" xref: Reactome:REACT_99910 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Taeniopygia guttata" is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0003908 name: methylated-DNA-[protein]-cysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] subset: gosubset_prok synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "MGMT" EXACT [] synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: MetaCyc:2.1.1.63-RXN xref: Reactome:REACT_102488 "MGMT/hAGT mediated DNA Damage Reversal, Canis familiaris" xref: Reactome:REACT_103267 "MGMT/hAGT mediated DNA Damage Reversal, Gallus gallus" xref: Reactome:REACT_103543 "MGMT/hAGT mediated DNA Damage Reversal, Dictyostelium discoideum" xref: Reactome:REACT_104382 "MGMT/hAGT mediated DNA Damage Reversal, Taeniopygia guttata" xref: Reactome:REACT_108289 "MGMT/hAGT mediated DNA Damage Reversal, Sus scrofa" xref: Reactome:REACT_115725 "MGMT mediated DNA Damage Reversal, Gallus gallus" xref: Reactome:REACT_1876 "MGMT/hAGT mediated DNA Damage Reversal, Homo sapiens" xref: Reactome:REACT_28063 "MGMT/hAGT mediated DNA Damage Reversal, Mus musculus" xref: Reactome:REACT_29167 "MGMT/hAGT mediated DNA Damage Reversal, Mycobacterium tuberculosis" xref: Reactome:REACT_31652 "MGMT/hAGT mediated DNA Damage Reversal, Staphylococcus aureus N315" xref: Reactome:REACT_82211 "MGMT/hAGT mediated DNA Damage Reversal, Danio rerio" xref: Reactome:REACT_89238 "MGMT/hAGT mediated DNA Damage Reversal, Saccharomyces cerevisiae" xref: Reactome:REACT_92208 "MGMT/hAGT mediated DNA Damage Reversal, Drosophila melanogaster" xref: Reactome:REACT_94426 "MGMT/hAGT mediated DNA Damage Reversal, Rattus norvegicus" xref: Reactome:REACT_96080 "MGMT/hAGT mediated DNA Damage Reversal, Xenopus tropicalis" xref: Reactome:REACT_98636 "MGMT/hAGT mediated DNA Damage Reversal, Caenorhabditis elegans" is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0003909 name: DNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094] subset: gosubset_prok xref: EC:6.5.1.- xref: Reactome:REACT_100095 "DNA ligation via the single-nucleotide replacement pathway, Bos taurus" xref: Reactome:REACT_100592 "Joining of adjacent Okazaki fragments, Canis familiaris" xref: Reactome:REACT_101774 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Caenorhabditis elegans" xref: Reactome:REACT_102755 "Ligation of DNA and formation of Holliday structures following repair synthesis, Gallus gallus" xref: Reactome:REACT_102810 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_102989 "Ligation of DNA at sites of patch replacement, Rattus norvegicus" xref: Reactome:REACT_103194 "Joining of adjacent Okazaki fragments, Mus musculus" xref: Reactome:REACT_103238 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Canis familiaris" xref: Reactome:REACT_103332 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Drosophila melanogaster" xref: Reactome:REACT_103589 "Ligation of DNA and formation of Holliday structures following repair synthesis, Mycobacterium tuberculosis" xref: Reactome:REACT_103607 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Mus musculus" xref: Reactome:REACT_103914 "Ligation of DNA and formation of Holliday structures following repair synthesis, Plasmodium falciparum" xref: Reactome:REACT_104033 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Sus scrofa" xref: Reactome:REACT_105041 "Ligation of DNA and formation of Holliday structures following repair synthesis, Saccharomyces cerevisiae" xref: Reactome:REACT_105804 "Ligation of DNA and formation of Holliday structures following repair synthesis, Dictyostelium discoideum" xref: Reactome:REACT_106130 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_106909 "Ligation of DNA and formation of Holliday structures following repair synthesis, Canis familiaris" xref: Reactome:REACT_106919 "Joining of adjacent Okazaki fragments of the C-strand, Oryza sativa" xref: Reactome:REACT_107577 "Ligation of DNA and formation of Holliday structures following repair synthesis, Drosophila melanogaster" xref: Reactome:REACT_107734 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Mus musculus" xref: Reactome:REACT_107864 "DNA ligation via the single-nucleotide replacement pathway, Dictyostelium discoideum" xref: Reactome:REACT_108464 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Rattus norvegicus" xref: Reactome:REACT_108675 "Ligation of DNA at sites of patch replacement, Mus musculus" xref: Reactome:REACT_109229 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Plasmodium falciparum" xref: Reactome:REACT_109434 "Joining of adjacent Okazaki fragments, Mycobacterium tuberculosis" xref: Reactome:REACT_109730 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Schizosaccharomyces pombe" xref: Reactome:REACT_109841 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_110352 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Caenorhabditis elegans" xref: Reactome:REACT_112118 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Mus musculus" xref: Reactome:REACT_112246 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Sus scrofa" xref: Reactome:REACT_113076 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Xenopus tropicalis" xref: Reactome:REACT_113217 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Gallus gallus" xref: Reactome:REACT_113661 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Canis familiaris" xref: Reactome:REACT_113851 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Bos taurus" xref: Reactome:REACT_114038 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Rattus norvegicus" xref: Reactome:REACT_114285 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Danio rerio" xref: Reactome:REACT_114706 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Taeniopygia guttata" xref: Reactome:REACT_115886 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Gallus gallus" xref: Reactome:REACT_12 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Homo sapiens" xref: Reactome:REACT_1247 "Ligation of DNA at sites of patch replacement, Homo sapiens" xref: Reactome:REACT_1659 "DNA ligation via the single-nucleotide replacement pathway, Homo sapiens" xref: Reactome:REACT_1889 "Joining of adjacent Okazaki fragments, Homo sapiens" xref: Reactome:REACT_2181 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Homo sapiens" xref: Reactome:REACT_29134 "Ligation of DNA and formation of Holliday structures following repair synthesis, Rattus norvegicus" xref: Reactome:REACT_29359 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Oryza sativa" xref: Reactome:REACT_29498 "Joining of adjacent Okazaki fragments of the C-strand, Mus musculus" xref: Reactome:REACT_29665 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Bos taurus" xref: Reactome:REACT_29882 "Ligation of DNA at sites of patch replacement, Xenopus tropicalis" xref: Reactome:REACT_30614 "Joining of adjacent Okazaki fragments, Caenorhabditis elegans" xref: Reactome:REACT_31624 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Arabidopsis thaliana" xref: Reactome:REACT_31707 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Dictyostelium discoideum" xref: Reactome:REACT_31800 "Ligation of DNA at sites of patch replacement, Sus scrofa" xref: Reactome:REACT_32203 "Joining of adjacent Okazaki fragments, Gallus gallus" xref: Reactome:REACT_32488 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Rattus norvegicus" xref: Reactome:REACT_33776 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Gallus gallus" xref: Reactome:REACT_34177 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Bos taurus" xref: Reactome:REACT_34490 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Danio rerio" xref: Reactome:REACT_527 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Homo sapiens" xref: Reactome:REACT_77023 "Ligation of DNA and formation of Holliday structures following repair synthesis, Mus musculus" xref: Reactome:REACT_77057 "Joining of adjacent Okazaki fragments, Dictyostelium discoideum" xref: Reactome:REACT_78542 "Joining of adjacent Okazaki fragments, Sus scrofa" xref: Reactome:REACT_78969 "Joining of adjacent Okazaki fragments of the C-strand, Bos taurus" xref: Reactome:REACT_79227 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Sus scrofa" xref: Reactome:REACT_79753 "Joining of adjacent Okazaki fragments, Xenopus tropicalis" xref: Reactome:REACT_7994 "Joining of adjacent Okazaki fragments of the C-strand, Homo sapiens" xref: Reactome:REACT_80840 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Xenopus tropicalis" xref: Reactome:REACT_81358 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Dictyostelium discoideum" xref: Reactome:REACT_81832 "Ligation of DNA and formation of Holliday structures following repair synthesis, Sus scrofa" xref: Reactome:REACT_819 "Ligation of DNA and formation of Holliday structures following repair synthesis, Homo sapiens" xref: Reactome:REACT_81990 "Joining of adjacent Okazaki fragments of the C-strand, Danio rerio" xref: Reactome:REACT_82032 "Joining of adjacent Okazaki fragments, Schizosaccharomyces pombe" xref: Reactome:REACT_82667 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Schizosaccharomyces pombe" xref: Reactome:REACT_82701 "DNA ligation via the single-nucleotide replacement pathway, Xenopus tropicalis" xref: Reactome:REACT_82930 "Ligation of DNA and formation of Holliday structures following repair synthesis, Caenorhabditis elegans" xref: Reactome:REACT_83571 "Ligation of DNA at sites of patch replacement, Danio rerio" xref: Reactome:REACT_84527 "Joining of adjacent Okazaki fragments of the C-strand, Xenopus tropicalis" xref: Reactome:REACT_84993 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Arabidopsis thaliana" xref: Reactome:REACT_85398 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Drosophila melanogaster" xref: Reactome:REACT_85781 "Joining of adjacent Okazaki fragments of the C-strand, Schizosaccharomyces pombe" xref: Reactome:REACT_85839 "Joining of adjacent Okazaki fragments, Plasmodium falciparum" xref: Reactome:REACT_85910 "Joining of adjacent Okazaki fragments of the C-strand, Canis familiaris" xref: Reactome:REACT_85997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Canis familiaris" xref: Reactome:REACT_86056 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus" xref: Reactome:REACT_86721 "Joining of adjacent Okazaki fragments, Saccharomyces cerevisiae" xref: Reactome:REACT_87237 "Ligation of DNA at sites of patch replacement, Arabidopsis thaliana" xref: Reactome:REACT_88790 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Oryza sativa" xref: Reactome:REACT_88893 "Joining of adjacent Okazaki fragments, Rattus norvegicus" xref: Reactome:REACT_89311 "DNA ligation via the single-nucleotide replacement pathway, Mus musculus" xref: Reactome:REACT_89618 "Joining of adjacent Okazaki fragments of the C-strand, Rattus norvegicus" xref: Reactome:REACT_89621 "Ligation of DNA and formation of Holliday structures following repair synthesis, Bos taurus" xref: Reactome:REACT_89952 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Plasmodium falciparum" xref: Reactome:REACT_90164 "Joining of adjacent Okazaki fragments, Drosophila melanogaster" xref: Reactome:REACT_90240 "Ligation of DNA and formation of Holliday structures following repair synthesis, Oryza sativa" xref: Reactome:REACT_90705 "Joining of adjacent Okazaki fragments, Danio rerio" xref: Reactome:REACT_9073 "2-LTR formation due to circularization of viral DNA, Homo sapiens" xref: Reactome:REACT_90997 "Joining of adjacent Okazaki fragments, Oryza sativa" xref: Reactome:REACT_91447 "Ligation of DNA at sites of patch replacement, Canis familiaris" xref: Reactome:REACT_91602 "DNA ligation via the single-nucleotide replacement pathway, Canis familiaris" xref: Reactome:REACT_92092 "Joining of adjacent Okazaki fragments of the C-strand, Sus scrofa" xref: Reactome:REACT_92345 "Joining of adjacent Okazaki fragments, Arabidopsis thaliana" xref: Reactome:REACT_92550 "Ligation of DNA and formation of Holliday structures following repair synthesis, Arabidopsis thaliana" xref: Reactome:REACT_92807 "Ligation of DNA at sites of patch replacement, Bos taurus" xref: Reactome:REACT_93826 "DNA ligation via the single-nucleotide replacement pathway, Danio rerio" xref: Reactome:REACT_94103 "DNA ligation via the single-nucleotide replacement pathway, Rattus norvegicus" xref: Reactome:REACT_94317 "Joining of adjacent Okazaki fragments of the C-strand, Arabidopsis thaliana" xref: Reactome:REACT_95309 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Mycobacterium tuberculosis" xref: Reactome:REACT_95407 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Mycobacterium tuberculosis" xref: Reactome:REACT_96323 "Ligation of DNA and formation of Holliday structures following repair synthesis, Schizosaccharomyces pombe" xref: Reactome:REACT_97779 "Ligation of DNA and formation of Holliday structures following repair synthesis, Xenopus tropicalis" xref: Reactome:REACT_97800 "Ligation of DNA and formation of Holliday structures following repair synthesis, Danio rerio" xref: Reactome:REACT_98012 "Joining of adjacent Okazaki fragments, Bos taurus" xref: Reactome:REACT_98339 "Ligation of DNA at sites of patch replacement, Oryza sativa" xref: Reactome:REACT_99685 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Danio rerio" is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0003910 name: DNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "sealase activity" RELATED [EC:6.5.1.1] xref: EC:6.5.1.1 xref: MetaCyc:DNA-LIGASE-ATP-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003911 name: DNA ligase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] xref: EC:6.5.1.2 xref: MetaCyc:DNA-LIGASE-NAD+-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003912 name: DNA nucleotidylexotransferase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] synonym: "addase activity" EXACT [EC:2.7.7.31] synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] synonym: "TdT" RELATED [EC:2.7.7.31] synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] xref: EC:2.7.7.31 xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0003913 name: DNA photolyase activity namespace: molecular_function def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] subset: gosubset_prok xref: EC:4.1.99.- xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0003914 name: DNA (6-4) photolyase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] xref: EC:4.1.99.13 xref: MetaCyc:RXN-10771 is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003916 name: DNA topoisomerase activity namespace: molecular_function alt_id: GO:0009387 def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] subset: gosubset_prok xref: EC:5.99.1.- xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003677 ! DNA binding is_a: GO:0016853 ! isomerase activity [Term] id: GO:0003917 name: DNA topoisomerase type I activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] synonym: "omega-protein activity" RELATED [EC:5.99.1.2] synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] synonym: "swivelase activity" RELATED [EC:5.99.1.2] synonym: "topoisomerase" BROAD [EC:5.99.1.2] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] xref: EC:5.99.1.2 xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003918 name: DNA topoisomerase type II (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3] synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3] synonym: "DNA gyrase activity" EXACT [] synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3] synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3] synonym: "DNA topoisomerase IV activity" EXACT [] synonym: "DNA topoisomerase type II activity" RELATED [] synonym: "DNA-gyrase activity" EXACT [EC:5.99.1.3] synonym: "topoisomerase" BROAD [EC:5.99.1.3] synonym: "topoisomerase II" RELATED [] synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3] xref: EC:5.99.1.3 xref: MetaCyc:5.99.1.3-RXN xref: Wikipedia:Type_II_topoisomerase is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0061505 ! DNA topoisomerase II activity [Term] id: GO:0003919 name: FMN adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17240] subset: gosubset_prok synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "ATP:FMN adenylyltransferase activity" EXACT [] synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] xref: EC:2.7.7.2 xref: KEGG:R00161 xref: MetaCyc:FADSYN-RXN xref: Reactome:REACT_100498 "FMN is futher phosphorylated to FAD, Taeniopygia guttata" xref: Reactome:REACT_101323 "FMN is futher phosphorylated to FAD, Arabidopsis thaliana" xref: Reactome:REACT_101363 "FMN is futher phosphorylated to FAD, Oryza sativa" xref: Reactome:REACT_103632 "FMN is futher phosphorylated to FAD, Sus scrofa" xref: Reactome:REACT_11128 "FMN is futher phosphorylated to FAD, Homo sapiens" xref: Reactome:REACT_32090 "FMN is futher phosphorylated to FAD, Dictyostelium discoideum" xref: Reactome:REACT_32724 "FMN is futher phosphorylated to FAD, Danio rerio" xref: Reactome:REACT_34649 "FMN is futher phosphorylated to FAD, Plasmodium falciparum" xref: Reactome:REACT_80112 "FMN is futher phosphorylated to FAD, Mus musculus" xref: Reactome:REACT_81244 "FMN is futher phosphorylated to FAD, Rattus norvegicus" xref: Reactome:REACT_85313 "FMN is futher phosphorylated to FAD, Canis familiaris" xref: Reactome:REACT_85342 "FMN is futher phosphorylated to FAD, Schizosaccharomyces pombe" xref: Reactome:REACT_85926 "FMN is futher phosphorylated to FAD, Saccharomyces cerevisiae" xref: Reactome:REACT_91206 "FMN is futher phosphorylated to FAD, Caenorhabditis elegans" xref: Reactome:REACT_92304 "FMN is futher phosphorylated to FAD, Bos taurus" xref: Reactome:REACT_92992 "FMN is futher phosphorylated to FAD, Xenopus tropicalis" xref: RHEA:17240 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003920 name: GMP reductase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188] comment: Note that this function was formerly EC:1.6.6.8. subset: gosubset_prok synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] xref: EC:1.7.1.7 xref: KEGG:R01134 xref: MetaCyc:GMP-REDUCT-RXN xref: Reactome:REACT_21383 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2], Homo sapiens" xref: RHEA:17188 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0003921 name: GMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1] synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1] synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1] synonym: "XMP aminase activity" EXACT [EC:6.3.4.1] xref: EC:6.3.4.1 xref: MetaCyc:GMP-SYN-NH3-RXN xref: Reactome:REACT_101174 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Bos taurus" xref: Reactome:REACT_105280 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_106308 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Taeniopygia guttata" xref: Reactome:REACT_107658 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Plasmodium falciparum" xref: Reactome:REACT_108131 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Dictyostelium discoideum" xref: Reactome:REACT_109470 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_110787 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Oryza sativa" xref: Reactome:REACT_114078 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Xenopus tropicalis" xref: Reactome:REACT_28584 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Sus scrofa" xref: Reactome:REACT_29905 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Gallus gallus" xref: Reactome:REACT_32520 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Staphylococcus aureus N315" xref: Reactome:REACT_32733 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_37631 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Canis familiaris" xref: Reactome:REACT_62336 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Mus musculus" xref: Reactome:REACT_628 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Homo sapiens" xref: Reactome:REACT_78067 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Arabidopsis thaliana" xref: Reactome:REACT_82243 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_90423 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_91249 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Danio rerio" xref: Reactome:REACT_96003 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Escherichia coli" xref: Reactome:REACT_96357 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Caenorhabditis elegans" xref: RHEA:18304 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003922 name: GMP synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2] subset: gosubset_prok synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] xref: EC:6.3.5.2 xref: MetaCyc:GMP-SYN-GLUT-RXN xref: Reactome:REACT_116095 "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate, Gallus gallus" xref: RHEA:11683 xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003923 name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309] xref: EC:3.-.-.- xref: Reactome:REACT_100692 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Rattus norvegicus" xref: Reactome:REACT_101782 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Danio rerio" xref: Reactome:REACT_103715 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Canis familiaris" xref: Reactome:REACT_113833 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Xenopus tropicalis" xref: Reactome:REACT_1777 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Homo sapiens" xref: Reactome:REACT_34799 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Sus scrofa" xref: Reactome:REACT_90230 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Mus musculus" xref: Reactome:REACT_92319 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Bos taurus" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: Reactome:REACT_100432 "trans-Golgi Network Vesicle Scission, Mus musculus" xref: Reactome:REACT_100708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_101121 "trans-Golgi Network Vesicle Scission, Rattus norvegicus" xref: Reactome:REACT_101520 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_101563 "Loss of Sar1b GTPase, Arabidopsis thaliana" xref: Reactome:REACT_101678 "G-protein alpha subunit is inactivated, Gallus gallus" xref: Reactome:REACT_102040 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis" xref: Reactome:REACT_102208 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Danio rerio" xref: Reactome:REACT_102307 "Adenylate cyclase increases the GTPase activity of Gi alpha, Gallus gallus" xref: Reactome:REACT_102371 "Vesicle Uncoating, Oryza sativa" xref: Reactome:REACT_102510 "trans-Golgi Network Vesicle Scission, Bos taurus" xref: Reactome:REACT_102532 "Loss of Sar1b GTPase, Danio rerio" xref: Reactome:REACT_103518 "trans-Golgi Network Lysosomal Vesicle Scission, Sus scrofa" xref: Reactome:REACT_104081 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_104477 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_104739 "Loss of Sar1b GTPase, Dictyostelium discoideum" xref: Reactome:REACT_105323 "trans-Golgi Network Vesicle Scission, Canis familiaris" xref: Reactome:REACT_105697 "G-protein alpha subunit is inactivated, Saccharomyces cerevisiae" xref: Reactome:REACT_105708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_105854 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_106121 "Vesicle Uncoating, Saccharomyces cerevisiae" xref: Reactome:REACT_106217 "Hydrolysis of eEF1A:GTP, Dictyostelium discoideum" xref: Reactome:REACT_106301 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Mus musculus" xref: Reactome:REACT_106528 "trans-Golgi Network Lysosomal Vesicle Scission, Canis familiaris" xref: Reactome:REACT_107176 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_107306 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_107730 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_107820 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Canis familiaris" xref: Reactome:REACT_108363 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_108653 "G-protein alpha subunit is inactivated, Bos taurus" xref: Reactome:REACT_108825 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Drosophila melanogaster" xref: Reactome:REACT_108837 "trans-Golgi Network Vesicle Scission, Xenopus tropicalis" xref: Reactome:REACT_109360 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_109897 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Danio rerio" xref: Reactome:REACT_110131 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_110443 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_110557 "trans-Golgi Network Vesicle Scission, Danio rerio" xref: Reactome:REACT_110859 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_110879 "G-protein alpha subunit is inactivated, Canis familiaris" xref: Reactome:REACT_110931 "G-protein alpha subunit is inactivated, Sus scrofa" xref: Reactome:REACT_111994 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_112104 "Endocytosis (internalization) of clathrin-coated vesicle, Sus scrofa" xref: Reactome:REACT_112254 "Endocytosis (internalization) of clathrin-coated vesicle, Xenopus tropicalis" xref: Reactome:REACT_112389 "Disassembly of COPII coated vesicle, Gallus gallus" xref: Reactome:REACT_112587 "trans-Golgi Network Vesicle Scission, Schizosaccharomyces pombe" xref: Reactome:REACT_112651 "Vesicle Uncoating, Xenopus tropicalis" xref: Reactome:REACT_112671 "Vesicle Uncoating, Plasmodium falciparum" xref: Reactome:REACT_113058 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_113209 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_113727 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_113832 "Formation of clathrin coated vesicle, Bos taurus" xref: Reactome:REACT_113952 "Formation of clathrin coated vesicle, Schizosaccharomyces pombe" xref: Reactome:REACT_113954 "Endocytosis (internalization) of clathrin-coated vesicle, Schizosaccharomyces pombe" xref: Reactome:REACT_114148 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_114153 "Loss of Sar1b GTPase, Xenopus tropicalis" xref: Reactome:REACT_114188 "Formation of clathrin coated vesicle, Sus scrofa" xref: Reactome:REACT_114210 "G-protein alpha subunit is inactivated, Schizosaccharomyces pombe" xref: Reactome:REACT_114331 "trans-Golgi Network Vesicle Scission, Taeniopygia guttata" xref: Reactome:REACT_114379 "Formation of clathrin coated vesicle, Taeniopygia guttata" xref: Reactome:REACT_114384 "Hydrolysis of eEF1A:GTP, Gallus gallus" xref: Reactome:REACT_114532 "Formation of clathrin coated vesicle, Xenopus tropicalis" xref: Reactome:REACT_114620 "Endocytosis (internalization) of clathrin-coated vesicle, Taeniopygia guttata" xref: Reactome:REACT_114824 "trans-Golgi Network Lysosomal Vesicle Scission, Taeniopygia guttata" xref: Reactome:REACT_115229 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_115324 "Endocytosis (internalization) of clathrin-coated vesicle, Bos taurus" xref: Reactome:REACT_12396 "Loss of Sar1b GTPase, Homo sapiens" xref: Reactome:REACT_12397 "Endocytosis (internalization) of clathrin-coated vesicle, Homo sapiens" xref: Reactome:REACT_12456 "Vesicle Uncoating, Homo sapiens" xref: Reactome:REACT_12612 "Endocytosis of clathrin-coated vesicle, Rattus norvegicus" xref: Reactome:REACT_15316 "G-protein alpha subunit is inactivated, Homo sapiens" xref: Reactome:REACT_15335 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Homo sapiens" xref: Reactome:REACT_15449 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Homo sapiens" xref: Reactome:REACT_15495 "Adenylate cyclase increases the GTPase activity of Gi alpha, Homo sapiens" xref: Reactome:REACT_19123 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19178 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19186 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19194 "trans-Golgi Network Lysosomal Vesicle Scission, Homo sapiens" xref: Reactome:REACT_19219 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19255 "trans-Golgi Network Vesicle Scission, Homo sapiens" xref: Reactome:REACT_19317 "G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_22359 "Formation of clathrin coated vesicle, Homo sapiens" xref: Reactome:REACT_28065 "Vesicle Uncoating, Sus scrofa" xref: Reactome:REACT_28251 "Hydrolysis of eEF1A:GTP, Danio rerio" xref: Reactome:REACT_28269 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Gallus gallus" xref: Reactome:REACT_29162 "trans-Golgi Network Lysosomal Vesicle Scission, Mus musculus" xref: Reactome:REACT_30456 "Hydrolysis of eEF1A:GTP, Plasmodium falciparum" xref: Reactome:REACT_30463 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Bos taurus" xref: Reactome:REACT_30562 "Endocytosis (internalization) of clathrin-coated vesicle, Caenorhabditis elegans" xref: Reactome:REACT_30687 "G-protein alpha subunit is inactivated, Xenopus tropicalis" xref: Reactome:REACT_30707 "trans-Golgi Network Vesicle Scission, Caenorhabditis elegans" xref: Reactome:REACT_30942 "Vesicle Uncoating, Rattus norvegicus" xref: Reactome:REACT_31226 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_31474 "Formation of clathrin coated vesicle, Danio rerio" xref: Reactome:REACT_31530 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Caenorhabditis elegans" xref: Reactome:REACT_31599 "trans-Golgi Network Lysosomal Vesicle Scission, Danio rerio" xref: Reactome:REACT_31709 "Hydrolysis of eEF1A:GTP, Drosophila melanogaster" xref: Reactome:REACT_31727 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata" xref: Reactome:REACT_31850 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_32006 "Loss of Sar1b GTPase, Canis familiaris" xref: Reactome:REACT_32028 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_32914 "Vesicle Uncoating, Dictyostelium discoideum" xref: Reactome:REACT_33948 "trans-Golgi Network Lysosomal Vesicle Scission, Rattus norvegicus" xref: Reactome:REACT_34113 "Vesicle Uncoating, Schizosaccharomyces pombe" xref: Reactome:REACT_34480 "G-protein alpha subunit is inactivated, Caenorhabditis elegans" xref: Reactome:REACT_34592 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_34735 "Adenylate cyclase increases the GTPase activity of Gi alpha, Taeniopygia guttata" xref: Reactome:REACT_348 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_36834 "trans-Golgi Network Lysosomal Vesicle Scission, Bos taurus" xref: Reactome:REACT_37542 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_552 "Hydrolysis of eEF1A:GTP, Homo sapiens" xref: Reactome:REACT_6171 "Hydrolysis of Ran:GTP to Ran:GDP, Homo sapiens" xref: Reactome:REACT_712 "Hydrolysis of reEF1A:GTP, Oryctolagus cuniculus" xref: Reactome:REACT_75799 "Disassembly of COPII coated vesicle, Homo sapiens" xref: Reactome:REACT_77032 "Hydrolysis of eEF1A:GTP, Canis familiaris" xref: Reactome:REACT_77303 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_78069 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_78231 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_78653 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Bos taurus" xref: Reactome:REACT_78945 "G-protein alpha subunit is inactivated, Rattus norvegicus" xref: Reactome:REACT_79558 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_79620 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Mus musculus" xref: Reactome:REACT_80275 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_80612 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_81304 "Loss of Sar1b GTPase, Taeniopygia guttata" xref: Reactome:REACT_81448 "Endocytosis (internalization) of clathrin-coated vesicle, Canis familiaris" xref: Reactome:REACT_81580 "Disassembly of COPII coated vesicle, Mus musculus" xref: Reactome:REACT_81664 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_81879 "Vesicle Uncoating, Drosophila melanogaster" xref: Reactome:REACT_82203 "Formation of clathrin coated vesicle, Canis familiaris" xref: Reactome:REACT_82263 "G-protein alpha subunit is inactivated, Taeniopygia guttata" xref: Reactome:REACT_82457 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_82603 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_82704 "Loss of Sar1b GTPase, Rattus norvegicus" xref: Reactome:REACT_83308 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus" xref: Reactome:REACT_83403 "G-protein alpha subunit is inactivated, Drosophila melanogaster" xref: Reactome:REACT_83440 "Hydrolysis of eEF1A:GTP, Schizosaccharomyces pombe" xref: Reactome:REACT_83730 "Loss of Sar1b GTPase, Plasmodium falciparum" xref: Reactome:REACT_84204 "Endocytosis (internalization) of clathrin-coated vesicle, Danio rerio" xref: Reactome:REACT_84553 "Vesicle Uncoating, Canis familiaris" xref: Reactome:REACT_84696 "G-protein alpha subunit is inactivated, Danio rerio" xref: Reactome:REACT_84712 "Hydrolysis of eEF1A:GTP, Saccharomyces cerevisiae" xref: Reactome:REACT_84735 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_85008 "Vesicle Uncoating, Danio rerio" xref: Reactome:REACT_85418 "Loss of Sar1b GTPase, Gallus gallus" xref: Reactome:REACT_85769 "Disassembly of COPII coated vesicle, Danio rerio" xref: Reactome:REACT_85972 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Canis familiaris" xref: Reactome:REACT_86227 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_86358 "trans-Golgi Network Lysosomal Vesicle Scission, Caenorhabditis elegans" xref: Reactome:REACT_86400 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_86630 "Vesicle Uncoating, Mus musculus" xref: Reactome:REACT_86760 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Gallus gallus" xref: Reactome:REACT_86972 "Loss of Sar1b GTPase, Mus musculus" xref: Reactome:REACT_87409 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_87506 "Formation of clathrin coated vesicle, Rattus norvegicus" xref: Reactome:REACT_87558 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_87653 "Endocytosis (internalization) of clathrin-coated vesicle, Mus musculus" xref: Reactome:REACT_87661 "Formation of clathrin coated vesicle, Drosophila melanogaster" xref: Reactome:REACT_88045 "Vesicle Uncoating, Gallus gallus" xref: Reactome:REACT_88357 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_89231 "Loss of Sar1b GTPase, Bos taurus" xref: Reactome:REACT_89292 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_89416 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_89668 "trans-Golgi Network Lysosomal Vesicle Scission, Xenopus tropicalis" xref: Reactome:REACT_89763 "Vesicle Uncoating, Taeniopygia guttata" xref: Reactome:REACT_90050 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_90064 "Hydrolysis of eEF1A:GTP, Mus musculus" xref: Reactome:REACT_90517 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_90703 "G-protein alpha subunit is inactivated, Dictyostelium discoideum" xref: Reactome:REACT_91199 "Adenylate cyclase increases the GTPase activity of Gi alpha, Bos taurus" xref: Reactome:REACT_91588 "trans-Golgi Network Vesicle Scission, Drosophila melanogaster" xref: Reactome:REACT_92176 "Endocytosis (internalization) of clathrin-coated vesicle, Drosophila melanogaster" xref: Reactome:REACT_92197 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_92198 "Loss of Sar1b GTPase, Oryza sativa" xref: Reactome:REACT_92450 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_93249 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_93305 "Loss of Sar1b GTPase, Sus scrofa" xref: Reactome:REACT_93641 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_93742 "G-protein alpha subunit is inactivated, Mus musculus" xref: Reactome:REACT_93772 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_94019 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_94095 "trans-Golgi Network Vesicle Scission, Sus scrofa" xref: Reactome:REACT_94305 "Adenylate cyclase increases the GTPase activity of Gi alpha, Xenopus tropicalis" xref: Reactome:REACT_94760 "Adenylate cyclase increases the GTPase activity of Gi alpha, Danio rerio" xref: Reactome:REACT_95238 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus" xref: Reactome:REACT_95563 "Adenylate cyclase increases the GTPase activity of Gi alpha, Canis familiaris" xref: Reactome:REACT_96019 "Loss of Sar1b GTPase, Drosophila melanogaster" xref: Reactome:REACT_96132 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_96223 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_96612 "Adenylate cyclase increases the GTPase activity of Gi alpha, Rattus norvegicus" xref: Reactome:REACT_96881 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis" xref: Reactome:REACT_97284 "Loss of Sar1b GTPase, Saccharomyces cerevisiae" xref: Reactome:REACT_97405 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata" xref: Reactome:REACT_97595 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_97794 "Loss of Sar1b GTPase, Schizosaccharomyces pombe" xref: Reactome:REACT_98431 "Formation of clathrin coated vesicle, Caenorhabditis elegans" xref: Reactome:REACT_98556 "Vesicle Uncoating, Bos taurus" xref: Reactome:REACT_98837 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_98859 "Adenylate cyclase increases the GTPase activity of Gi alpha, Mus musculus" xref: Reactome:REACT_99479 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_99533 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_99616 "Formation of clathrin coated vesicle, Mus musculus" xref: RHEA:19672 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003925 name: small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN] comment: This term was made obsolete because it represents a gene product and contains cellular component information. is_obsolete: true replaced_by: GO:0003924 [Term] id: GO:0003926 name: ARF small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003927 name: heterotrimeric G-protein GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN] comment: This term was made obsolete because it represents a cellular component. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0005834 [Term] id: GO:0003928 name: RAB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003929 name: RAN small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0006606 [Term] id: GO:0003930 name: RAS small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 [Term] id: GO:0003931 name: Rho small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0007010 [Term] id: GO:0003932 name: SAR small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0046903 [Term] id: GO:0003933 name: GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators] subset: gosubset_prok xref: EC:3.5.4.- is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003934 name: GTP cyclohydrolase I activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16] subset: gosubset_prok synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] xref: EC:3.5.4.16 xref: KEGG:R00424 xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN xref: Reactome:REACT_111143 "GCH1 reduces GTP to dihydroneopterin triphosphate, Homo sapiens" xref: RHEA:17476 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003935 name: GTP cyclohydrolase II activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23707] subset: gosubset_prok synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] xref: EC:3.5.4.25 xref: KEGG:R00425 xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN xref: RHEA:23707 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003936 name: hydrogen-transporting two-sector ATPase activity namespace: molecular_function alt_id: GO:0004006 alt_id: GO:0008729 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "proton-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0003937 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] subset: gosubset_prok synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: Reactome:REACT_100264 "FAICAR => IMP + H2O, Mycobacterium tuberculosis" xref: Reactome:REACT_101327 "FAICAR => IMP + H2O, Oryza sativa" xref: Reactome:REACT_101441 "FAICAR => IMP + H2O, Canis familiaris" xref: Reactome:REACT_101852 "FAICAR => IMP + H2O, Caenorhabditis elegans" xref: Reactome:REACT_105279 "FAICAR => IMP + H2O, Danio rerio" xref: Reactome:REACT_107619 "FAICAR => IMP + H2O, Rattus norvegicus" xref: Reactome:REACT_110740 "FAICAR => IMP + H2O, Gallus gallus" xref: Reactome:REACT_116131 "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O, Gallus gallus" xref: Reactome:REACT_263 "FAICAR => IMP + H2O, Homo sapiens" xref: Reactome:REACT_29038 "FAICAR => IMP + H2O, Xenopus tropicalis" xref: Reactome:REACT_30340 "FAICAR => IMP + H2O, Bos taurus" xref: Reactome:REACT_30737 "FAICAR => IMP + H2O, Arabidopsis thaliana" xref: Reactome:REACT_79659 "FAICAR => IMP + H2O, Schizosaccharomyces pombe" xref: Reactome:REACT_80364 "FAICAR => IMP + H2O, Dictyostelium discoideum" xref: Reactome:REACT_80795 "FAICAR => IMP + H2O, Sus scrofa" xref: Reactome:REACT_80881 "FAICAR => IMP + H2O, Mus musculus" xref: Reactome:REACT_83814 "FAICAR => IMP + H2O, Drosophila melanogaster" xref: Reactome:REACT_93074 "FAICAR => IMP + H2O, Escherichia coli" xref: Reactome:REACT_93482 "FAICAR => IMP + H2O, Taeniopygia guttata" xref: Reactome:REACT_94292 "FAICAR => IMP + H2O, Staphylococcus aureus N315" xref: Reactome:REACT_98029 "FAICAR => IMP + H2O, Saccharomyces cerevisiae" xref: RHEA:18448 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003938 name: IMP dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] subset: gosubset_prok synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] xref: EC:1.1.1.205 xref: MetaCyc:IMP-DEHYDROG-RXN xref: Reactome:REACT_102501 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Dictyostelium discoideum" xref: Reactome:REACT_110875 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Taeniopygia guttata" xref: Reactome:REACT_116090 "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+, Gallus gallus" xref: Reactome:REACT_1488 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Homo sapiens" xref: Reactome:REACT_31646 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Gallus gallus" xref: Reactome:REACT_32201 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Escherichia coli" xref: Reactome:REACT_33579 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Schizosaccharomyces pombe" xref: Reactome:REACT_33597 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Staphylococcus aureus N315" xref: Reactome:REACT_33701 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Plasmodium falciparum" xref: Reactome:REACT_77612 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Mycobacterium tuberculosis" xref: Reactome:REACT_79622 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Xenopus tropicalis" xref: Reactome:REACT_80105 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Drosophila melanogaster" xref: Reactome:REACT_86742 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Danio rerio" xref: Reactome:REACT_86832 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Bos taurus" xref: Reactome:REACT_88830 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Canis familiaris" xref: Reactome:REACT_94520 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Sus scrofa" xref: Reactome:REACT_94662 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Rattus norvegicus" xref: Reactome:REACT_96045 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Oryza sativa" xref: Reactome:REACT_96517 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Caenorhabditis elegans" xref: Reactome:REACT_96945 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Arabidopsis thaliana" xref: Reactome:REACT_97319 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Mus musculus" xref: Reactome:REACT_98553 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Saccharomyces cerevisiae" xref: RHEA:11711 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003939 name: L-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. subset: gosubset_prok synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] xref: EC:1.1.1.14 xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN xref: RHEA:10163 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003940 name: L-iduronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] xref: EC:3.2.1.76 xref: MetaCyc:3.2.1.76-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003941 name: L-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] comment: Note that this function was formerly EC:4.3.1.13. subset: gosubset_prok synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 xref: MetaCyc:4.3.1.17-RXN xref: RHEA:19172 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0003942 name: N-acetyl-gamma-glutamyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] subset: gosubset_prok synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] xref: EC:1.2.1.38 xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN xref: RHEA:21591 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0003943 name: N-acetylgalactosamine-4-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] subset: gosubset_prok synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] synonym: "arylsulfatase B" EXACT [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] xref: EC:3.1.6.12 xref: MetaCyc:3.1.6.12-RXN xref: Wikipedia:Arylsulfatase_B is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0003944 name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: MetaCyc:3.1.4.45-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0003945 name: N-acetyllactosamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] subset: gosubset_prok synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-GalT" RELATED [EC:2.4.1.90] synonym: "beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "Gal-T" RELATED [EC:2.4.1.90] synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] xref: EC:2.4.1.90 xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN xref: RHEA:17748 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003947 name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] xref: EC:2.4.1.92 xref: MetaCyc:2.4.1.92-RXN xref: RHEA:12591 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0003948 name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547] subset: gosubset_prok synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] xref: EC:3.5.1.26 xref: KEGG:R03421 xref: MetaCyc:3.5.1.26-RXN xref: RHEA:11547 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003949 name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15472] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] xref: EC:5.3.1.16 xref: KEGG:R04640 xref: MetaCyc:PRIBFAICARPISOM-RXN xref: RHEA:15472 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0003950 name: NAD+ ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] subset: gosubset_prok synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] synonym: "NAD ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] xref: EC:2.4.2.30 xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003951 name: NAD+ kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] subset: gosubset_prok synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] synonym: "NAD kinase activity" EXACT [] synonym: "NADK" RELATED [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] xref: EC:2.7.1.23 xref: KEGG:R00104 xref: MetaCyc:NAD-KIN-RXN xref: Reactome:REACT_100710 "NAD+ is phosphorylated to NADP+, Danio rerio" xref: Reactome:REACT_102495 "NAD+ is phosphorylated to NADP+, Dictyostelium discoideum" xref: Reactome:REACT_104124 "NAD+ is phosphorylated to NADP+, Arabidopsis thaliana" xref: Reactome:REACT_105015 "NAD+ is phosphorylated to NADP+, Rattus norvegicus" xref: Reactome:REACT_106084 "NAD+ is phosphorylated to NADP+, Mycobacterium tuberculosis" xref: Reactome:REACT_106904 "NAD+ is phosphorylated to NADP+, Escherichia coli" xref: Reactome:REACT_11234 "NAD+ is phosphorylated to NADP+, Homo sapiens" xref: Reactome:REACT_28799 "NAD+ is phosphorylated to NADP+, Canis familiaris" xref: Reactome:REACT_30450 "NAD+ is phosphorylated to NADP+, Gallus gallus" xref: Reactome:REACT_32843 "NAD+ is phosphorylated to NADP+, Oryza sativa" xref: Reactome:REACT_82142 "NAD+ is phosphorylated to NADP+, Xenopus tropicalis" xref: Reactome:REACT_86304 "NAD+ is phosphorylated to NADP+, Mus musculus" xref: Reactome:REACT_88716 "NAD+ is phosphorylated to NADP+, Taeniopygia guttata" xref: Reactome:REACT_93050 "NAD+ is phosphorylated to NADP+, Bos taurus" xref: Reactome:REACT_94691 "NAD+ is phosphorylated to NADP+, Drosophila melanogaster" xref: RHEA:18632 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0003952 name: NAD+ synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] subset: gosubset_prok synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] xref: EC:6.3.5.1 xref: MetaCyc:NAD-SYNTH-GLN-RXN xref: Reactome:REACT_101777 "Amidation of deamino-NAD+ to NAD+, Gallus gallus" xref: Reactome:REACT_106358 "Amidation of deamino-NAD+ to NAD+, Taeniopygia guttata" xref: Reactome:REACT_11135 "Amidation of deamino-NAD+ to NAD+, Homo sapiens" xref: Reactome:REACT_112596 "Amidation of deamino-NAD+ to NAD+, Xenopus tropicalis" xref: Reactome:REACT_33314 "Amidation of deamino-NAD+ to NAD+, Sus scrofa" xref: Reactome:REACT_34274 "Amidation of deamino-NAD+ to NAD+, Plasmodium falciparum" xref: Reactome:REACT_34563 "Amidation of deamino-NAD+ to NAD+, Oryza sativa" xref: Reactome:REACT_78384 "Amidation of deamino-NAD+ to NAD+, Rattus norvegicus" xref: Reactome:REACT_79027 "Amidation of deamino-NAD+ to NAD+, Danio rerio" xref: Reactome:REACT_80179 "Amidation of deamino-NAD+ to NAD+, Mus musculus" xref: Reactome:REACT_81822 "Amidation of deamino-NAD+ to NAD+, Arabidopsis thaliana" xref: Reactome:REACT_84016 "Amidation of deamino-NAD+ to NAD+, Dictyostelium discoideum" xref: Reactome:REACT_86176 "Amidation of deamino-NAD+ to NAD+, Saccharomyces cerevisiae" xref: Reactome:REACT_86976 "Amidation of deamino-NAD+ to NAD+, Bos taurus" xref: Reactome:REACT_90083 "Amidation of deamino-NAD+ to NAD+, Canis familiaris" xref: Reactome:REACT_90698 "Amidation of deamino-NAD+ to NAD+, Drosophila melanogaster" xref: Reactome:REACT_93162 "Amidation of deamino-NAD+ to NAD+, Mycobacterium tuberculosis" xref: Reactome:REACT_98272 "Amidation of deamino-NAD+ to NAD+, Schizosaccharomyces pombe" xref: Reactome:REACT_98584 "Amidation of deamino-NAD+ to NAD+, Caenorhabditis elegans" xref: RHEA:24387 xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003953 name: NAD+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5] subset: gosubset_prok synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5] synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5] synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5] synonym: "DPNase activity" EXACT [EC:3.2.2.5] synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD nucleosidase activity" EXACT [] synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NADase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5] xref: EC:3.2.2.5 xref: MetaCyc:NADNUCLEOSID-RXN xref: RHEA:16304 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003954 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] subset: gosubset_prok synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: MetaCyc:NADH-DEHYDROGENASE-RXN xref: RHEA:11359 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0003955 name: NAD(P)H dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone." [EC:1.6.5.2] subset: gosubset_prok synonym: "azoreductase activity" BROAD [EC:1.6.5.2] synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] synonym: "diaphorase activity" BROAD [EC:1.6.5.2] synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] synonym: "NQO1" RELATED [EC:1.6.5.2] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "QR1" RELATED [EC:1.6.5.2] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: MetaCyc:NQOR-RXN xref: UM-BBD_reactionID:r0227 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0003956 name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.31 xref: MetaCyc:2.4.2.31-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003957 name: NAD(P)+ transhydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf, MetaCyc:PYRNUTRANSHYDROGEN-RXN] subset: gosubset_prok synonym: "H+-thase" BROAD [EC:1.6.1.1] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] xref: EC:1.6.1.1 xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN xref: RHEA:11695 is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity [Term] id: GO:0003958 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] subset: gosubset_prok synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0003959 name: NADPH dehydrogenase activity namespace: molecular_function alt_id: GO:0008468 alt_id: GO:0016660 def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1] subset: gosubset_prok synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] synonym: "OYE" RELATED [EC:1.6.99.1] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] xref: EC:1.6.99.1 xref: MetaCyc:NADPH-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0523 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0003960 name: NADPH:quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] subset: gosubset_prok synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: MetaCyc:QOR-RXN is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0003961 name: O-acetylhomoserine aminocarboxypropyltransferase activity namespace: molecular_function alt_id: GO:0019282 def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [EC:2.5.1.49] comment: Note that this function was formerly EC:4.2.99.10. subset: gosubset_prok synonym: "4.2.99.9" RELATED [] synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [] synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] xref: EC:2.5.1.49 xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN xref: RHEA:10051 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003962 name: cystathionine gamma-synthase activity namespace: molecular_function alt_id: GO:0000505 def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] comment: Formerly EC 4.2.99.9. subset: gosubset_prok synonym: "CTT gamma synthase activity" EXACT [] synonym: "cystathionine g-synthase activity" EXACT [] synonym: "cystathionine gamma synthase activity" EXACT [] synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] xref: EC:2.5.1.48 xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN xref: RHEA:20400 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003963 name: RNA-3'-phosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] subset: gosubset_prok synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0003964 name: RNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] subset: gosubset_prok synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] synonym: "revertase activity" RELATED [EC:2.7.7.49] synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RT" RELATED [EC:2.7.7.49] xref: EC:2.7.7.49 xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:REACT_9039 "Synthesis of minus strand strong stop DNA (-sssDNA), Homo sapiens" xref: Reactome:REACT_9049 "Minus strand DNA synthesis resumes, Homo sapiens" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003966 name: RNA-directed DNA polymerase, transposon encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003967 name: RNA-directed DNA polymerase, group II intron encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003968 name: RNA-directed RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] subset: gosubset_prok synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] synonym: "PB1 proteins" RELATED [EC:2.7.7.48] synonym: "PB2 proteins" RELATED [EC:2.7.7.48] synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] synonym: "polymerase L" RELATED [EC:2.7.7.48] synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] synonym: "RDRP" RELATED [EC:2.7.7.48] synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "transcriptase" BROAD [EC:2.7.7.48] xref: EC:2.7.7.48 xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:REACT_6210 "Elongation of viral mRNA, Homo sapiens" xref: Reactome:REACT_6239 "Priming and Initiation of Transcription, Homo sapiens" xref: Reactome:REACT_6264 "Polyadenylation and Termination, Homo sapiens" xref: Reactome:REACT_9404 "cRNA Extension, Homo sapiens" xref: Reactome:REACT_9438 "vRNA Extension, Homo sapiens" xref: Reactome:REACT_9487 "Initiation of vRNA Synthesis, Homo sapiens" xref: Reactome:REACT_9513 "Initiation of cRNA Synthesis, Homo sapiens" is_a: GO:0034062 ! RNA polymerase activity [Term] id: GO:0003969 name: RNA editase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a biological process. is_obsolete: true [Term] id: GO:0003972 name: RNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3] subset: gosubset_prok synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] xref: EC:6.5.1.3 xref: MetaCyc:RNA-LIGASE-ATP-RXN is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0003973 name: (S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [EC:1.1.3.15] subset: gosubset_prok synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003974 name: UDP-N-acetylglucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] subset: gosubset_prok synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] xref: EC:5.1.3.7 xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN xref: RHEA:20520 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003975 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] subset: gosubset_prok synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: MetaCyc:2.7.8.15-RXN xref: Reactome:REACT_22147 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate, Homo sapiens" xref: RHEA:13292 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003976 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: MetaCyc:2.7.8.17-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003977 name: UDP-N-acetylglucosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13512] subset: gosubset_prok synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] xref: EC:2.7.7.23 xref: KEGG:R00416 xref: MetaCyc:NAG1P-URIDYLTRANS-RXN xref: Reactome:REACT_22397 "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine, Homo sapiens" xref: RHEA:13512 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0003978 name: UDP-glucose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] subset: gosubset_prok synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] xref: EC:5.1.3.2 xref: MetaCyc:UDPGLUCEPIM-RXN xref: Reactome:REACT_102168 "UDP-galactose <=> UDP-glucose, Rattus norvegicus" xref: Reactome:REACT_115000 "UDP-galactose <=> UDP-glucose, Arabidopsis thaliana" xref: Reactome:REACT_115332 "UDP-galactose <=> UDP-glucose, Schizosaccharomyces pombe" xref: Reactome:REACT_115411 "UDP-galactose <=> UDP-glucose, Oryza sativa" xref: Reactome:REACT_1315 "UDP-galactose <=> UDP-glucose, Homo sapiens" xref: Reactome:REACT_31550 "UDP-galactose <=> UDP-glucose, Bos taurus" xref: Reactome:REACT_33528 "UDP-galactose <=> UDP-glucose, Gallus gallus" xref: Reactome:REACT_34575 "UDP-galactose <=> UDP-glucose, Xenopus tropicalis" xref: Reactome:REACT_78749 "UDP-galactose <=> UDP-glucose, Staphylococcus aureus N315" xref: Reactome:REACT_78984 "UDP-galactose <=> UDP-glucose, Canis familiaris" xref: Reactome:REACT_83662 "UDP-galactose <=> UDP-glucose, Taeniopygia guttata" xref: Reactome:REACT_84187 "UDP-galactose <=> UDP-glucose, Drosophila melanogaster" xref: Reactome:REACT_87173 "UDP-galactose <=> UDP-glucose, Mus musculus" xref: Reactome:REACT_87677 "UDP-galactose <=> UDP-glucose, Caenorhabditis elegans" xref: Reactome:REACT_90321 "UDP-galactose <=> UDP-glucose, Escherichia coli" xref: Reactome:REACT_91321 "UDP-galactose <=> UDP-glucose, Danio rerio" xref: Reactome:REACT_94034 "UDP-galactose <=> UDP-glucose, Dictyostelium discoideum" xref: Reactome:REACT_97325 "UDP-galactose <=> UDP-glucose, Saccharomyces cerevisiae" xref: RHEA:22171 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003979 name: UDP-glucose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23599] subset: gosubset_prok xref: EC:1.1.1.22 xref: KEGG:R00286 xref: MetaCyc:UGD-RXN xref: Reactome:REACT_101674 "UDP-glucose is oxidised to UDP-glucuronate, Gallus gallus" xref: Reactome:REACT_102401 "UDP-glucose is oxidised to UDP-glucuronate, Drosophila melanogaster" xref: Reactome:REACT_103324 "UDP-glucose is oxidised to UDP-glucuronate, Oryza sativa" xref: Reactome:REACT_104028 "UDP-glucose is oxidised to UDP-glucuronate, Mus musculus" xref: Reactome:REACT_106090 "UDP-glucose is oxidised to UDP-glucuronate, Taeniopygia guttata" xref: Reactome:REACT_112524 "UDP-glucose is oxidised to UDP-glucuronate, Escherichia coli" xref: Reactome:REACT_28362 "UDP-glucose is oxidised to UDP-glucuronate, Caenorhabditis elegans" xref: Reactome:REACT_30359 "UDP-glucose is oxidised to UDP-glucuronate, Arabidopsis thaliana" xref: Reactome:REACT_32524 "UDP-glucose is oxidised to UDP-glucuronate, Rattus norvegicus" xref: Reactome:REACT_6876 "UDP-glucose is oxidised to UDP-glucuronate, Homo sapiens" xref: Reactome:REACT_82981 "UDP-glucose is oxidised to UDP-glucuronate, Mycobacterium tuberculosis" xref: Reactome:REACT_90704 "UDP-glucose is oxidised to UDP-glucuronate, Danio rerio" xref: Reactome:REACT_90852 "UDP-glucose is oxidised to UDP-glucuronate, Canis familiaris" xref: Reactome:REACT_93404 "UDP-glucose is oxidised to UDP-glucuronate, Bos taurus" xref: Reactome:REACT_98306 "UDP-glucose is oxidised to UDP-glucuronate, Staphylococcus aureus N315" xref: Reactome:REACT_98484 "UDP-glucose is oxidised to UDP-glucuronate, Xenopus tropicalis" xref: RHEA:23599 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003980 name: UDP-glucose:glycoprotein glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828] synonym: "UGGT activity" EXACT [] xref: EC:2.4.1.- xref: Reactome:REACT_25264 "Re-addition of a glucose on the alpha 1,3 branch, Homo sapiens" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003983 name: UTP:glucose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19892] subset: gosubset_prok synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] xref: EC:2.7.7.9 xref: KEGG:R00289 xref: MetaCyc:GLUC1PURIDYLTRANS-RXN xref: Reactome:REACT_101085 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Saccharomyces cerevisiae" xref: Reactome:REACT_101096 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Sus scrofa" xref: Reactome:REACT_103410 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Schizosaccharomyces pombe" xref: Reactome:REACT_103497 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Taeniopygia guttata" xref: Reactome:REACT_104734 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Oryza sativa" xref: Reactome:REACT_105080 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Caenorhabditis elegans" xref: Reactome:REACT_110476 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Danio rerio" xref: Reactome:REACT_82849 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Xenopus tropicalis" xref: Reactome:REACT_84996 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Arabidopsis thaliana" xref: Reactome:REACT_85597 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Canis familiaris" xref: Reactome:REACT_86 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Homo sapiens" xref: Reactome:REACT_87986 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Mus musculus" xref: Reactome:REACT_90031 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Drosophila melanogaster" xref: Reactome:REACT_91019 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Gallus gallus" xref: Reactome:REACT_94840 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Dictyostelium discoideum" xref: Reactome:REACT_95999 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Bos taurus" xref: Reactome:REACT_98501 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Rattus norvegicus" xref: RHEA:19892 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0003984 name: acetolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] comment: Note that this function was formerly EC:4.1.3.18. subset: gosubset_prok synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] xref: EC:2.2.1.6 xref: MetaCyc:ACETOLACTSYN-RXN xref: RHEA:20504 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0003985 name: acetyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] subset: gosubset_prok synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "thiolase II" RELATED [EC:2.3.1.9] xref: EC:2.3.1.9 xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN xref: Reactome:REACT_100461 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Danio rerio" xref: Reactome:REACT_102319 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_102321 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Danio rerio" xref: Reactome:REACT_102563 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Rattus norvegicus" xref: Reactome:REACT_102876 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_103568 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Drosophila melanogaster" xref: Reactome:REACT_103940 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Canis familiaris" xref: Reactome:REACT_104958 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Mus musculus" xref: Reactome:REACT_105003 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_105426 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Bos taurus" xref: Reactome:REACT_105877 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_106542 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Dictyostelium discoideum" xref: Reactome:REACT_109820 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Dictyostelium discoideum" xref: Reactome:REACT_109899 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Bos taurus" xref: Reactome:REACT_112932 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Caenorhabditis elegans" xref: Reactome:REACT_113533 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Caenorhabditis elegans" xref: Reactome:REACT_114812 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Caenorhabditis elegans" xref: Reactome:REACT_1478 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Homo sapiens" xref: Reactome:REACT_28462 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Plasmodium falciparum" xref: Reactome:REACT_28526 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Plasmodium falciparum" xref: Reactome:REACT_28646 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Canis familiaris" xref: Reactome:REACT_31277 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Mus musculus" xref: Reactome:REACT_31739 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_31976 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Xenopus tropicalis" xref: Reactome:REACT_32156 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Gallus gallus" xref: Reactome:REACT_47 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Homo sapiens" xref: Reactome:REACT_79103 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_79150 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Rattus norvegicus" xref: Reactome:REACT_80792 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_81504 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_82257 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_83250 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Gallus gallus" xref: Reactome:REACT_83764 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Drosophila melanogaster" xref: Reactome:REACT_84180 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Gallus gallus" xref: Reactome:REACT_84285 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_85056 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Danio rerio" xref: Reactome:REACT_85622 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Taeniopygia guttata" xref: Reactome:REACT_86508 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Bos taurus" xref: Reactome:REACT_88187 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Rattus norvegicus" xref: Reactome:REACT_884 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Homo sapiens" xref: Reactome:REACT_92663 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_92854 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Mus musculus" xref: Reactome:REACT_93534 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Dictyostelium discoideum" xref: Reactome:REACT_93658 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Canis familiaris" xref: Reactome:REACT_93946 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Drosophila melanogaster" xref: Reactome:REACT_96819 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Plasmodium falciparum" xref: Reactome:REACT_97416 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_97821 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Saccharomyces cerevisiae" xref: RHEA:21039 xref: UM-BBD_enzymeID:e0144 is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0003986 name: acetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20292] subset: gosubset_prok synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] xref: EC:3.1.2.1 xref: KEGG:R00227 xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN xref: Reactome:REACT_102494 "acetyl-CoA + H2O => acetate + CoASH, Canis familiaris" xref: Reactome:REACT_104855 "acetyl-CoA + H2O => acetate + CoASH, Oryza sativa" xref: Reactome:REACT_105619 "acetyl-CoA + H2O => acetate + CoASH, Xenopus tropicalis" xref: Reactome:REACT_105926 "acetyl-CoA + H2O => acetate + CoASH, Caenorhabditis elegans" xref: Reactome:REACT_109012 "acetyl-CoA + H2O => acetate + CoASH, Arabidopsis thaliana" xref: Reactome:REACT_109195 "acetyl-CoA + H2O => acetate + CoASH, Mus musculus" xref: Reactome:REACT_16974 "acetyl-CoA + H2O => acetate + CoASH, Homo sapiens" xref: Reactome:REACT_77871 "acetyl-CoA + H2O => acetate + CoASH, Escherichia coli" xref: Reactome:REACT_83459 "acetyl-CoA + H2O => acetate + CoASH, Mycobacterium tuberculosis" xref: Reactome:REACT_86591 "acetyl-CoA + H2O => acetate + CoASH, Gallus gallus" xref: Reactome:REACT_88142 "acetyl-CoA + H2O => acetate + CoASH, Danio rerio" xref: Reactome:REACT_89514 "acetyl-CoA + H2O => acetate + CoASH, Sus scrofa" xref: Reactome:REACT_94225 "acetyl-CoA + H2O => acetate + CoASH, Rattus norvegicus" xref: Reactome:REACT_94231 "acetyl-CoA + H2O => acetate + CoASH, Taeniopygia guttata" xref: Reactome:REACT_98144 "acetyl-CoA + H2O => acetate + CoASH, Saccharomyces cerevisiae" xref: Reactome:REACT_99433 "acetyl-CoA + H2O => acetate + CoASH, Bos taurus" xref: RHEA:20292 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003987 name: acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] subset: gosubset_prok synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] synonym: "acetate to acetyl-CoA" RELATED [] synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] synonym: "ACS" RELATED [EC:6.2.1.1] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] xref: EC:6.2.1.1 xref: MetaCyc:ACETATE--COA-LIGASE-RXN xref: Reactome:REACT_101761 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Canis familiaris" xref: Reactome:REACT_102092 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Rattus norvegicus" xref: Reactome:REACT_103963 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Arabidopsis thaliana" xref: Reactome:REACT_106135 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Mycobacterium tuberculosis" xref: Reactome:REACT_107058 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Xenopus tropicalis" xref: Reactome:REACT_112167 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Escherichia coli" xref: Reactome:REACT_21284 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial], Homo sapiens" xref: Reactome:REACT_30831 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Oryza sativa" xref: Reactome:REACT_31444 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Bos taurus" xref: Reactome:REACT_32745 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Danio rerio" xref: Reactome:REACT_553 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Homo sapiens" xref: Reactome:REACT_80622 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Drosophila melanogaster" xref: Reactome:REACT_84415 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Sus scrofa" xref: Reactome:REACT_85826 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Mus musculus" xref: Reactome:REACT_92738 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Taeniopygia guttata" xref: Reactome:REACT_96131 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Gallus gallus" xref: Reactome:REACT_98155 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Caenorhabditis elegans" xref: RHEA:23179 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003988 name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] subset: gosubset_prok synonym: "2-keto-acyl thiolase activity" EXACT [] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "KAT" RELATED [EC:2.3.1.16] synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "thiolase I" RELATED [EC:2.3.1.16] xref: EC:2.3.1.16 xref: MetaCyc:KETOACYLCOATHIOL-RXN xref: Reactome:REACT_106127 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Arabidopsis thaliana" xref: Reactome:REACT_106648 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_106889 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Gallus gallus" xref: Reactome:REACT_110593 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Sus scrofa" xref: Reactome:REACT_16946 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Homo sapiens" xref: Reactome:REACT_29227 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Canis familiaris" xref: Reactome:REACT_30577 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Oryza sativa" xref: Reactome:REACT_79644 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_83687 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Dictyostelium discoideum" xref: Reactome:REACT_85643 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Bos taurus" xref: Reactome:REACT_87029 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Mus musculus" xref: Reactome:REACT_88222 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Rattus norvegicus" xref: Reactome:REACT_93039 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Danio rerio" xref: Reactome:REACT_94311 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_99914 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Staphylococcus aureus N315" xref: RHEA:21567 xref: UM-BBD_reactionID:r1051 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0003989 name: acetyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] subset: gosubset_prok synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] xref: EC:6.4.1.2 xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN xref: Reactome:REACT_100526 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Oryza sativa" xref: Reactome:REACT_100609 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Rattus norvegicus" xref: Reactome:REACT_103671 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Saccharomyces cerevisiae" xref: Reactome:REACT_104374 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Bos taurus" xref: Reactome:REACT_105410 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Gallus gallus" xref: Reactome:REACT_109995 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Rattus norvegicus" xref: Reactome:REACT_11201 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Homo sapiens" xref: Reactome:REACT_114007 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Taeniopygia guttata" xref: Reactome:REACT_28375 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Xenopus tropicalis" xref: Reactome:REACT_28966 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Oryza sativa" xref: Reactome:REACT_29662 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Sus scrofa" xref: Reactome:REACT_30959 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Drosophila melanogaster" xref: Reactome:REACT_32583 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Drosophila melanogaster" xref: Reactome:REACT_33034 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Canis familiaris" xref: Reactome:REACT_34127 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Schizosaccharomyces pombe" xref: Reactome:REACT_34284 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Arabidopsis thaliana" xref: Reactome:REACT_590 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Homo sapiens" xref: Reactome:REACT_77884 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_80005 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Danio rerio" xref: Reactome:REACT_81142 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Dictyostelium discoideum" xref: Reactome:REACT_84058 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Danio rerio" xref: Reactome:REACT_87135 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Canis familiaris" xref: Reactome:REACT_88443 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_90395 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Gallus gallus" xref: Reactome:REACT_90662 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Arabidopsis thaliana" xref: Reactome:REACT_92102 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Bos taurus" xref: Reactome:REACT_92269 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Xenopus tropicalis" xref: Reactome:REACT_93364 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Dictyostelium discoideum" xref: Reactome:REACT_95365 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Mus musculus" xref: Reactome:REACT_97953 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Taeniopygia guttata" xref: Reactome:REACT_98607 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Mus musculus" xref: Reactome:REACT_99199 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Sus scrofa" xref: RHEA:11311 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: gosubset_prok synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN xref: Reactome:REACT_109174 "AcCho is hydrolysed to Cho and acetate by ACHE, Canis familiaris" xref: Reactome:REACT_14816 "AcCho is hydrolysed to Cho and acetate by ACHE, Homo sapiens" xref: Reactome:REACT_85985 "AcCho is hydrolysed to Cho and acetate by ACHE, Mus musculus" xref: Reactome:REACT_89645 "AcCho is hydrolysed to Cho and acetate by ACHE, Danio rerio" xref: Reactome:REACT_96859 "AcCho is hydrolysed to Cho and acetate by ACHE, Xenopus tropicalis" xref: Reactome:REACT_99846 "AcCho is hydrolysed to Cho and acetate by ACHE, Bos taurus" xref: RHEA:17564 is_a: GO:0004104 ! cholinesterase activity [Term] id: GO:0003991 name: acetylglutamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8] subset: gosubset_prok synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] xref: EC:2.7.2.8 xref: MetaCyc:ACETYLGLUTKIN-RXN xref: RHEA:14632 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0003992 name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity namespace: molecular_function alt_id: GO:0047318 def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18052] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine aminotransferase activity" BROAD [] synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11] synonym: "ACOAT activity" EXACT [EC:2.6.1.11] synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] xref: EC:2.6.1.11 xref: KEGG:R02283 xref: MetaCyc:ACETYLORNTRANSAM-RXN xref: RHEA:18052 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003993 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] subset: gosubset_prok synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: MetaCyc:ACID-PHOSPHATASE-RXN xref: Reactome:REACT_104847 "FMN can be hydrolyzed back to riboflavin, Mus musculus" xref: Reactome:REACT_11171 "FMN can be hydrolyzed back to riboflavin, Homo sapiens" xref: Reactome:REACT_80951 "FMN can be hydrolyzed back to riboflavin, Plasmodium falciparum" xref: Reactome:REACT_82194 "FMN can be hydrolyzed back to riboflavin, Bos taurus" xref: Reactome:REACT_82472 "FMN can be hydrolyzed back to riboflavin, Xenopus tropicalis" xref: Reactome:REACT_83480 "FMN can be hydrolyzed back to riboflavin, Caenorhabditis elegans" xref: Reactome:REACT_83568 "FMN can be hydrolyzed back to riboflavin, Canis familiaris" xref: Reactome:REACT_84333 "FMN can be hydrolyzed back to riboflavin, Sus scrofa" xref: Reactome:REACT_97154 "FMN can be hydrolyzed back to riboflavin, Danio rerio" xref: Reactome:REACT_97735 "FMN can be hydrolyzed back to riboflavin, Arabidopsis thaliana" xref: Reactome:REACT_99971 "FMN can be hydrolyzed back to riboflavin, Oryza sativa" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003994 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reactions: citrate = cis-aconitate + H2O, and cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. subset: gosubset_prok synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: Reactome:REACT_106698 "citrate <=> isocitrate, Saccharomyces cerevisiae" xref: Reactome:REACT_115701 "citrate <=> isocitrate, Gallus gallus" xref: Reactome:REACT_116024 "isocitrate <=> citrate, Gallus gallus" xref: Reactome:REACT_1898 "citrate <=> isocitrate, Homo sapiens" xref: Reactome:REACT_21262 "isocitrate <=> citrate, Homo sapiens" xref: Reactome:REACT_30406 "citrate <=> isocitrate, Caenorhabditis elegans" xref: Reactome:REACT_32627 "citrate <=> isocitrate, Rattus norvegicus" xref: Reactome:REACT_46526 "citrate <=> isocitrate, Schizosaccharomyces pombe" xref: Reactome:REACT_77059 "citrate <=> isocitrate, Bos taurus" xref: Reactome:REACT_77875 "citrate <=> isocitrate, Canis familiaris" xref: Reactome:REACT_77983 "citrate <=> isocitrate, Dictyostelium discoideum" xref: Reactome:REACT_78997 "citrate <=> isocitrate, Taeniopygia guttata" xref: Reactome:REACT_81376 "citrate <=> isocitrate, Mus musculus" xref: Reactome:REACT_82548 "citrate <=> isocitrate, Xenopus tropicalis" xref: Reactome:REACT_83980 "citrate <=> isocitrate, Gallus gallus" xref: Reactome:REACT_86078 "citrate <=> isocitrate, Danio rerio" xref: Reactome:REACT_90644 "citrate <=> isocitrate, Drosophila melanogaster" xref: Reactome:REACT_97737 "citrate <=> isocitrate, Sus scrofa" xref: RHEA:10231 xref: RHEA:22148 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003995 name: acyl-CoA dehydrogenase activity namespace: molecular_function alt_id: GO:0019109 def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] subset: gosubset_prok synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] xref: EC:1.3.99.3 xref: MetaCyc:ACYLCOADEHYDROG-RXN xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN xref: Reactome:REACT_100103 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Bos taurus" xref: Reactome:REACT_100162 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_100783 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_101760 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Sus scrofa" xref: Reactome:REACT_102752 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_102754 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Drosophila melanogaster" xref: Reactome:REACT_102759 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_103113 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_103307 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_103703 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Taeniopygia guttata" xref: Reactome:REACT_103943 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_105107 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Mycobacterium tuberculosis" xref: Reactome:REACT_105146 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Drosophila melanogaster" xref: Reactome:REACT_105296 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa" xref: Reactome:REACT_106191 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Mycobacterium tuberculosis" xref: Reactome:REACT_106900 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Drosophila melanogaster" xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio" xref: Reactome:REACT_107729 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_107750 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_108764 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_108765 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_108767 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_108853 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_108930 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_109051 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Caenorhabditis elegans" xref: Reactome:REACT_109106 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Taeniopygia guttata" xref: Reactome:REACT_109954 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Gallus gallus" xref: Reactome:REACT_110072 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_110834 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Gallus gallus" xref: Reactome:REACT_110858 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Xenopus tropicalis" xref: Reactome:REACT_1111 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Homo sapiens" xref: Reactome:REACT_113088 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Staphylococcus aureus N315" xref: Reactome:REACT_113123 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Staphylococcus aureus N315" xref: Reactome:REACT_114274 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_1177 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_1285 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Homo sapiens" xref: Reactome:REACT_1592 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_1742 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_1862 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_1912 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens" xref: Reactome:REACT_28111 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Xenopus tropicalis" xref: Reactome:REACT_28194 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_28196 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Drosophila melanogaster" xref: Reactome:REACT_28454 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Bos taurus" xref: Reactome:REACT_28855 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Taeniopygia guttata" xref: Reactome:REACT_30090 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_31237 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_31733 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Taeniopygia guttata" xref: Reactome:REACT_31777 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Mycobacterium tuberculosis" xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_32022 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_32213 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Sus scrofa" xref: Reactome:REACT_32236 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Caenorhabditis elegans" xref: Reactome:REACT_32631 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Drosophila melanogaster" xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio" xref: Reactome:REACT_32711 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Gallus gallus" xref: Reactome:REACT_32796 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa" xref: Reactome:REACT_33392 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_34132 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Mus musculus" xref: Reactome:REACT_34359 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Gallus gallus" xref: Reactome:REACT_34562 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Gallus gallus" xref: Reactome:REACT_398 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_43718 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens" xref: Reactome:REACT_442 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Homo sapiens" xref: Reactome:REACT_48070 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_62169 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Taeniopygia guttata" xref: Reactome:REACT_630 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Homo sapiens" xref: Reactome:REACT_77605 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_77947 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Canis familiaris" xref: Reactome:REACT_79468 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_79535 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Caenorhabditis elegans" xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_80889 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus" xref: Reactome:REACT_81632 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_82463 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_82480 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Dictyostelium discoideum" xref: Reactome:REACT_82527 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_82549 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Caenorhabditis elegans" xref: Reactome:REACT_82790 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Mus musculus" xref: Reactome:REACT_83350 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_83619 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Gallus gallus" xref: Reactome:REACT_83799 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Canis familiaris" xref: Reactome:REACT_83881 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Xenopus tropicalis" xref: Reactome:REACT_83955 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Drosophila melanogaster" xref: Reactome:REACT_83978 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Taeniopygia guttata" xref: Reactome:REACT_84492 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Drosophila melanogaster" xref: Reactome:REACT_85455 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Canis familiaris" xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus" xref: Reactome:REACT_86174 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus" xref: Reactome:REACT_86360 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Mycobacterium tuberculosis" xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus" xref: Reactome:REACT_88076 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Rattus norvegicus" xref: Reactome:REACT_88615 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_88846 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Mus musculus" xref: Reactome:REACT_89119 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_89472 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_89523 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_89534 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_89564 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Danio rerio" xref: Reactome:REACT_89974 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Bos taurus" xref: Reactome:REACT_91165 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_91800 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Mus musculus" xref: Reactome:REACT_92061 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_92316 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_92590 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_92851 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Caenorhabditis elegans" xref: Reactome:REACT_93155 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Rattus norvegicus" xref: Reactome:REACT_93287 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_93568 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_93952 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Mycobacterium tuberculosis" xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_94207 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Sus scrofa" xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus" xref: Reactome:REACT_94703 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_95023 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Danio rerio" xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_96588 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Danio rerio" xref: Reactome:REACT_96757 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Taeniopygia guttata" xref: Reactome:REACT_96770 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_96802 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Danio rerio" xref: Reactome:REACT_96926 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Sus scrofa" xref: Reactome:REACT_97590 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Canis familiaris" xref: Reactome:REACT_98382 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Bos taurus" xref: Reactome:REACT_98910 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Dictyostelium discoideum" xref: Reactome:REACT_99180 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Caenorhabditis elegans" xref: Reactome:REACT_99352 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Taeniopygia guttata" xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0003996 name: acyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C13 to C22." [CHEBI:15904, EC:6.2.1.3, GOC:mah] subset: gosubset_prok xref: EC:6.2.1.- is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003997 name: acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] subset: gosubset_prok synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] xref: EC:1.3.3.6 xref: MetaCyc:ACYL-COA-OXIDASE-RXN xref: Reactome:REACT_10003 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Homo sapiens" xref: Reactome:REACT_10074 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Homo sapiens" xref: Reactome:REACT_101202 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Sus scrofa" xref: Reactome:REACT_102703 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Canis familiaris" xref: Reactome:REACT_103315 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Xenopus tropicalis" xref: Reactome:REACT_104041 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Bos taurus" xref: Reactome:REACT_105955 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Arabidopsis thaliana" xref: Reactome:REACT_107417 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Gallus gallus" xref: Reactome:REACT_107469 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Danio rerio" xref: Reactome:REACT_109809 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_114247 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Caenorhabditis elegans" xref: Reactome:REACT_115434 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Drosophila melanogaster" xref: Reactome:REACT_17054 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Homo sapiens" xref: Reactome:REACT_28592 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_29191 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Gallus gallus" xref: Reactome:REACT_30183 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_30256 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Mus musculus" xref: Reactome:REACT_30656 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Mus musculus" xref: Reactome:REACT_33505 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Bos taurus" xref: Reactome:REACT_34639 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_34682 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Rattus norvegicus" xref: Reactome:REACT_78214 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Oryza sativa" xref: Reactome:REACT_78286 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Taeniopygia guttata" xref: Reactome:REACT_78800 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Bos taurus" xref: Reactome:REACT_80085 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_81057 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Oryza sativa" xref: Reactome:REACT_81512 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Gallus gallus" xref: Reactome:REACT_86463 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Canis familiaris" xref: Reactome:REACT_86667 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Sus scrofa" xref: Reactome:REACT_89834 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Mus musculus" xref: Reactome:REACT_90722 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Canis familiaris" xref: Reactome:REACT_95380 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Arabidopsis thaliana" xref: Reactome:REACT_97066 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Arabidopsis thaliana" xref: Reactome:REACT_97420 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_97865 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Oryza sativa" xref: Reactome:REACT_98266 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Sus scrofa" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0003998 name: acylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] subset: gosubset_prok synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] synonym: "GP 1-3" RELATED [EC:3.6.1.7] synonym: "Ho 1-3" RELATED [EC:3.6.1.7] xref: EC:3.6.1.7 xref: MetaCyc:ACYLPHOSPHATASE-RXN xref: RHEA:14968 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0003999 name: adenine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] subset: gosubset_prok synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "APRT activity" EXACT [EC:2.4.2.7] synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] xref: EC:2.4.2.7 xref: MetaCyc:ADENPRIBOSYLTRAN-RXN xref: Reactome:REACT_101521 "Adenine + PRPP => AMP + PPi, Danio rerio" xref: Reactome:REACT_103283 "Adenine + PRPP => AMP + PPi, Dictyostelium discoideum" xref: Reactome:REACT_103528 "Adenine + PRPP => AMP + PPi, Bos taurus" xref: Reactome:REACT_104835 "Adenine + PRPP => AMP + PPi, Taeniopygia guttata" xref: Reactome:REACT_104879 "Adenine + PRPP => AMP + PPi, Caenorhabditis elegans" xref: Reactome:REACT_165 "Adenine + PRPP => AMP + PPi, Homo sapiens" xref: Reactome:REACT_32070 "Adenine + PRPP => AMP + PPi, Escherichia coli" xref: Reactome:REACT_32930 "Adenine + PRPP => AMP + PPi, Mycobacterium tuberculosis" xref: Reactome:REACT_79242 "Adenine + PRPP => AMP + PPi, Mus musculus" xref: Reactome:REACT_84269 "Adenine + PRPP => AMP + PPi, Xenopus tropicalis" xref: Reactome:REACT_84345 "Adenine + PRPP => AMP + PPi, Saccharomyces cerevisiae" xref: Reactome:REACT_85331 "Adenine + PRPP => AMP + PPi, Rattus norvegicus" xref: Reactome:REACT_87474 "Adenine + PRPP => AMP + PPi, Schizosaccharomyces pombe" xref: Reactome:REACT_87859 "Adenine + PRPP => AMP + PPi, Sus scrofa" xref: Reactome:REACT_88309 "Adenine + PRPP => AMP + PPi, Staphylococcus aureus N315" xref: Reactome:REACT_90224 "Adenine + PRPP => AMP + PPi, Canis familiaris" xref: Reactome:REACT_90510 "Adenine + PRPP => AMP + PPi, Drosophila melanogaster" xref: RHEA:16612 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004000 name: adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] subset: gosubset_prok synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] synonym: "adenosine deaminase reaction" EXACT [] xref: EC:3.5.4.4 xref: MetaCyc:ADENODEAMIN-RXN xref: Reactome:REACT_107117 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Rattus norvegicus" xref: Reactome:REACT_107659 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Gallus gallus" xref: Reactome:REACT_113447 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Plasmodium falciparum" xref: Reactome:REACT_114346 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Mycobacterium tuberculosis" xref: Reactome:REACT_2135 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Homo sapiens" xref: Reactome:REACT_32268 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Bos taurus" xref: Reactome:REACT_34635 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Mus musculus" xref: Reactome:REACT_84913 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Canis familiaris" xref: Reactome:REACT_92015 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Caenorhabditis elegans" xref: Reactome:REACT_93814 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Danio rerio" xref: Reactome:REACT_98610 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Escherichia coli" xref: RHEA:24411 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004001 name: adenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] subset: gosubset_prok synonym: "adenosine 5-phosphotransferase activity" EXACT [] synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] xref: EC:2.7.1.20 xref: MetaCyc:ADENOSINE-KINASE-RXN xref: Reactome:REACT_102294 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Bos taurus" xref: Reactome:REACT_103994 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Dictyostelium discoideum" xref: Reactome:REACT_110560 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Canis familiaris" xref: Reactome:REACT_112074 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Oryza sativa" xref: Reactome:REACT_114269 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Arabidopsis thaliana" xref: Reactome:REACT_1728 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Homo sapiens" xref: Reactome:REACT_32035 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Saccharomyces cerevisiae" xref: Reactome:REACT_32321 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Gallus gallus" xref: Reactome:REACT_33598 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Xenopus tropicalis" xref: Reactome:REACT_78205 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Rattus norvegicus" xref: Reactome:REACT_78906 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Sus scrofa" xref: Reactome:REACT_80139 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Caenorhabditis elegans" xref: Reactome:REACT_80336 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Mus musculus" xref: Reactome:REACT_86275 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Taeniopygia guttata" xref: Reactome:REACT_95743 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Schizosaccharomyces pombe" xref: Reactome:REACT_96492 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Danio rerio" xref: RHEA:20827 is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004003 name: ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0003678 ! DNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0004004 name: ATP-dependent RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok xref: Reactome:REACT_75794 "Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex, Homo sapiens" is_a: GO:0003724 ! RNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008186 ! RNA-dependent ATPase activity [Term] id: GO:0004005 name: plasma membrane cation-transporting ATPase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005886 consider: GO:0019829 [Term] id: GO:0004007 name: heavy metal-exporting ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0046873 [Term] id: GO:0004008 name: copper-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)." [EC:3.6.3.4] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4] synonym: "copper exporting ATPase activity" EXACT [] synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4] synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] xref: EC:3.6.3.4 xref: MetaCyc:3.6.3.4-RXN xref: Reactome:REACT_25071 "Copper export from cells by copper-transporting ATPase1, Homo sapiens" xref: RHEA:10379 is_a: GO:0043682 ! copper-transporting ATPase activity [Term] id: GO:0004009 name: ATP-binding cassette (ABC) transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0004012 name: phospholipid-translocating ATPase activity namespace: molecular_function alt_id: GO:0008557 def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] subset: gosubset_prok synonym: "aminophospholipid-transporting ATPase" NARROW [] synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1] synonym: "flippase activity" BROAD [EC:3.6.3.1] synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1] synonym: "phospholipid translocating ATPase activity" EXACT [] synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1] xref: EC:3.6.3.1 xref: MetaCyc:3.6.3.1-RXN xref: Reactome:REACT_115892 "Aminophospholipids are transported from in the internal to the external side of the plasma membrane, Homo sapiens" xref: Reactome:REACT_24989 "P-type ATPase type IV subfamily transporters may mediate phospholipid transfer, Homo sapiens" xref: RHEA:14992 is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0043492 ! ATPase activity, coupled to movement of substances [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: gosubset_prok synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:REACT_100355 "S-adenoylhomocysteine is hydrolyzed, Bos taurus" xref: Reactome:REACT_100496 "S-adenoylhomocysteine is hydrolyzed, Rattus norvegicus" xref: Reactome:REACT_102024 "S-adenoylhomocysteine is hydrolyzed, Drosophila melanogaster" xref: Reactome:REACT_107160 "S-adenoylhomocysteine is hydrolyzed, Canis familiaris" xref: Reactome:REACT_109196 "S-adenoylhomocysteine is hydrolyzed, Mus musculus" xref: Reactome:REACT_109745 "S-adenoylhomocysteine is hydrolyzed, Oryza sativa" xref: Reactome:REACT_110610 "S-adenoylhomocysteine is hydrolyzed, Caenorhabditis elegans" xref: Reactome:REACT_28097 "S-adenoylhomocysteine is hydrolyzed, Mycobacterium tuberculosis" xref: Reactome:REACT_30892 "S-adenoylhomocysteine is hydrolyzed, Dictyostelium discoideum" xref: Reactome:REACT_31016 "S-adenoylhomocysteine is hydrolyzed, Gallus gallus" xref: Reactome:REACT_6756 "S-adenoylhomocysteine is hydrolyzed, Homo sapiens" xref: Reactome:REACT_77798 "S-adenoylhomocysteine is hydrolyzed, Danio rerio" xref: Reactome:REACT_77951 "S-adenoylhomocysteine is hydrolyzed, Saccharomyces cerevisiae" xref: Reactome:REACT_80809 "S-adenoylhomocysteine is hydrolyzed, Xenopus tropicalis" xref: Reactome:REACT_88005 "S-adenoylhomocysteine is hydrolyzed, Arabidopsis thaliana" xref: Reactome:REACT_95489 "S-adenoylhomocysteine is hydrolyzed, Taeniopygia guttata" xref: Reactome:REACT_99437 "S-adenoylhomocysteine is hydrolyzed, Schizosaccharomyces pombe" xref: RHEA:21711 is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0004014 name: adenosylmethionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15984] subset: gosubset_prok synonym: "adenosyl methionine decarboxylase activity" EXACT [] synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] xref: EC:4.1.1.50 xref: KEGG:R00178 xref: MetaCyc:SAMDECARB-RXN xref: Reactome:REACT_102265 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Gallus gallus" xref: Reactome:REACT_106380 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Taeniopygia guttata" xref: Reactome:REACT_106530 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Caenorhabditis elegans" xref: Reactome:REACT_108018 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Dictyostelium discoideum" xref: Reactome:REACT_109548 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Canis familiaris" xref: Reactome:REACT_110722 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Sus scrofa" xref: Reactome:REACT_14840 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Homo sapiens" xref: Reactome:REACT_28215 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Danio rerio" xref: Reactome:REACT_78516 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Drosophila melanogaster" xref: Reactome:REACT_79319 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Oryza sativa" xref: Reactome:REACT_80263 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Schizosaccharomyces pombe" xref: Reactome:REACT_81987 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Arabidopsis thaliana" xref: Reactome:REACT_89351 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Mus musculus" xref: Reactome:REACT_90930 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Xenopus tropicalis" xref: Reactome:REACT_96438 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Saccharomyces cerevisiae" xref: RHEA:15984 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004015 name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864] subset: gosubset_prok synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] xref: EC:2.6.1.62 xref: KEGG:R03231 xref: MetaCyc:DAPASYN-RXN xref: RHEA:16864 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004016 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] subset: gosubset_prok synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: MetaCyc:ADENYLATECYC-RXN xref: Reactome:REACT_101083 "Activated Adenylate cyclase catalyses cAMP synthesis, Gallus gallus" xref: Reactome:REACT_103498 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Sus scrofa" xref: Reactome:REACT_104211 "Adenylate cyclase converts ATP into cyclic AMP, Drosophila melanogaster" xref: Reactome:REACT_106348 "Activated Adenylate cyclase catalyses cAMP synthesis, Taeniopygia guttata" xref: Reactome:REACT_110132 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Bos taurus" xref: Reactome:REACT_110346 "Adenylate cyclase converts ATP into cyclic AMP, Caenorhabditis elegans" xref: Reactome:REACT_114273 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Xenopus tropicalis" xref: Reactome:REACT_114694 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Drosophila melanogaster" xref: Reactome:REACT_1292 "Activated Adenylate cyclase catalyses cAMP synthesis, Homo sapiens" xref: Reactome:REACT_15399 "Adenylate cyclase converts ATP into cyclic AMP, Homo sapiens" xref: Reactome:REACT_18321 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Homo sapiens" xref: Reactome:REACT_19249 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Homo sapiens" xref: Reactome:REACT_19407 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Canis familiaris" xref: Reactome:REACT_20564 "Activation of Adenylate Cyclase, Homo sapiens" xref: Reactome:REACT_28885 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Bos taurus" xref: Reactome:REACT_28984 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Caenorhabditis elegans" xref: Reactome:REACT_30072 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Danio rerio" xref: Reactome:REACT_30354 "Activated Adenylate cyclase catalyses cAMP synthesis, Caenorhabditis elegans" xref: Reactome:REACT_32296 "Adenylate cyclase converts ATP into cyclic AMP, Bos taurus" xref: Reactome:REACT_77589 "Activated Adenylate cyclase catalyses cAMP synthesis, Danio rerio" xref: Reactome:REACT_77648 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Danio rerio" xref: Reactome:REACT_77920 "Adenylate cyclase converts ATP into cyclic AMP, Canis familiaris" xref: Reactome:REACT_78464 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Taeniopygia guttata" xref: Reactome:REACT_78878 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Taeniopygia guttata" xref: Reactome:REACT_79135 "Adenylate cyclase converts ATP into cyclic AMP, Mus musculus" xref: Reactome:REACT_79837 "Adenylate cyclase converts ATP into cyclic AMP, Taeniopygia guttata" xref: Reactome:REACT_80253 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_80404 "Activated Adenylate cyclase catalyses cAMP synthesis, Mus musculus" xref: Reactome:REACT_80465 "Activated Adenylate cyclase catalyses cAMP synthesis, Drosophila melanogaster" xref: Reactome:REACT_80777 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_81089 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Sus scrofa" xref: Reactome:REACT_81527 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Canis familiaris" xref: Reactome:REACT_81605 "Adenylate cyclase converts ATP into cyclic AMP, Rattus norvegicus" xref: Reactome:REACT_84068 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Mus musculus" xref: Reactome:REACT_84304 "Adenylate cyclase converts ATP into cyclic AMP, Gallus gallus" xref: Reactome:REACT_84639 "Activated Adenylate cyclase catalyses cAMP synthesis, Canis familiaris" xref: Reactome:REACT_85469 "Adenylate cyclase converts ATP into cyclic AMP, Xenopus tropicalis" xref: Reactome:REACT_85953 "Adenylate cyclase converts ATP into cyclic AMP, Danio rerio" xref: Reactome:REACT_86733 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Xenopus tropicalis" xref: Reactome:REACT_87138 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Gallus gallus" xref: Reactome:REACT_92664 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Mus musculus" xref: Reactome:REACT_92794 "Activated Adenylate cyclase catalyses cAMP synthesis, Sus scrofa" xref: Reactome:REACT_93757 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_94136 "Activated Adenylate cyclase catalyses cAMP synthesis, Xenopus tropicalis" xref: Reactome:REACT_97516 "Activated Adenylate cyclase catalyses cAMP synthesis, Bos taurus" xref: RHEA:15392 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004017 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] subset: gosubset_prok synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: MetaCyc:ADENYL-KIN-RXN xref: Reactome:REACT_100300 "AMP + ATP <=> ADP + ADP [AK2], Schizosaccharomyces pombe" xref: Reactome:REACT_100354 "ADP + ADP <=> AMP + ATP [AK2], Dictyostelium discoideum" xref: Reactome:REACT_100509 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Drosophila melanogaster" xref: Reactome:REACT_100999 "ADP + ADP <=> AMP + ATP [AK2], Canis familiaris" xref: Reactome:REACT_101925 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Canis familiaris" xref: Reactome:REACT_101986 "ADP + ADP <=> AMP + ATP [AK2], Mus musculus" xref: Reactome:REACT_102985 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Sus scrofa" xref: Reactome:REACT_103652 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Mus musculus" xref: Reactome:REACT_104314 "ADP + ADP <=> AMP + ATP [AK2], Rattus norvegicus" xref: Reactome:REACT_106139 "ADP + ADP <=> AMP + ATP [AK2], Saccharomyces cerevisiae" xref: Reactome:REACT_107217 "ADP + ADP <=> AMP + ATP [AK2], Taeniopygia guttata" xref: Reactome:REACT_109890 "ADP + ADP <=> AMP + ATP [AK2], Oryza sativa" xref: Reactome:REACT_110965 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Drosophila melanogaster" xref: Reactome:REACT_114340 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Escherichia coli" xref: Reactome:REACT_114949 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Escherichia coli" xref: Reactome:REACT_2031 "ADP + ADP <=> AMP + ATP [AK2], Homo sapiens" xref: Reactome:REACT_29050 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Danio rerio" xref: Reactome:REACT_29136 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Caenorhabditis elegans" xref: Reactome:REACT_31416 "AMP + ATP <=> ADP + ADP [AK2], Bos taurus" xref: Reactome:REACT_31539 "ADP + ADP <=> AMP + ATP [AK2], Danio rerio" xref: Reactome:REACT_32379 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Taeniopygia guttata" xref: Reactome:REACT_32517 "AMP + ATP <=> ADP + ADP [AK2], Drosophila melanogaster" xref: Reactome:REACT_33002 "AMP + ATP <=> ADP + ADP [AK2], Rattus norvegicus" xref: Reactome:REACT_33987 "AMP + ATP <=> ADP + ADP [AK2], Danio rerio" xref: Reactome:REACT_34796 "ADP + ADP <=> AMP + ATP [AK2], Bos taurus" xref: Reactome:REACT_390 "AMP + ATP <=> ADP + ADP [AK2], Homo sapiens" xref: Reactome:REACT_643 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Homo sapiens" xref: Reactome:REACT_763 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Homo sapiens" xref: Reactome:REACT_78886 "AMP + ATP <=> ADP + ADP [AK2], Gallus gallus" xref: Reactome:REACT_78917 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Danio rerio" xref: Reactome:REACT_79891 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Mus musculus" xref: Reactome:REACT_80849 "AMP + ATP <=> ADP + ADP [AK2], Saccharomyces cerevisiae" xref: Reactome:REACT_80989 "AMP + ATP <=> ADP + ADP [AK2], Dictyostelium discoideum" xref: Reactome:REACT_82847 "AMP + ATP <=> ADP + ADP [AK2], Mus musculus" xref: Reactome:REACT_84010 "AMP + ATP <=> ADP + ADP [AK2], Arabidopsis thaliana" xref: Reactome:REACT_84704 "ADP + ADP <=> AMP + ATP [AK2], Xenopus tropicalis" xref: Reactome:REACT_85367 "ADP + ADP <=> AMP + ATP [AK2], Drosophila melanogaster" xref: Reactome:REACT_85846 "ADP + ADP <=> AMP + ATP [AK2], Gallus gallus" xref: Reactome:REACT_87077 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Caenorhabditis elegans" xref: Reactome:REACT_87621 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Canis familiaris" xref: Reactome:REACT_88917 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Bos taurus" xref: Reactome:REACT_88924 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Taeniopygia guttata" xref: Reactome:REACT_90905 "AMP + ATP <=> ADP + ADP [AK2], Escherichia coli" xref: Reactome:REACT_91426 "ADP + ADP <=> AMP + ATP [AK2], Caenorhabditis elegans" xref: Reactome:REACT_91927 "AMP + ATP <=> ADP + ADP [AK2], Oryza sativa" xref: Reactome:REACT_92343 "ADP + ADP <=> AMP + ATP [AK2], Arabidopsis thaliana" xref: Reactome:REACT_92843 "ADP + ADP <=> AMP + ATP [AK2], Schizosaccharomyces pombe" xref: Reactome:REACT_92937 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Xenopus tropicalis" xref: Reactome:REACT_93851 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Xenopus tropicalis" xref: Reactome:REACT_94373 "AMP + ATP <=> ADP + ADP [AK2], Canis familiaris" xref: Reactome:REACT_95537 "AMP + ATP <=> ADP + ADP [AK2], Taeniopygia guttata" xref: Reactome:REACT_96203 "AMP + ATP <=> ADP + ADP [AK2], Xenopus tropicalis" xref: Reactome:REACT_96441 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Bos taurus" xref: Reactome:REACT_97658 "AMP + ATP <=> ADP + ADP [AK2], Caenorhabditis elegans" xref: Reactome:REACT_98806 "ADP + ADP <=> AMP + ATP [AK2], Escherichia coli" xref: Reactome:REACT_99365 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Sus scrofa" xref: RHEA:12976 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004018 name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] subset: gosubset_prok synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG:R01083 xref: MetaCyc:AMPSYN-RXN xref: Reactome:REACT_101613 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Mycobacterium tuberculosis" xref: Reactome:REACT_101814 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Schizosaccharomyces pombe" xref: Reactome:REACT_102293 "SAICAR => AICAR + Fumarate, Taeniopygia guttata" xref: Reactome:REACT_103002 "SAICAR => AICAR + Fumarate, Drosophila melanogaster" xref: Reactome:REACT_1042 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Homo sapiens" xref: Reactome:REACT_104702 "SAICAR => AICAR + Fumarate, Staphylococcus aureus N315" xref: Reactome:REACT_105061 "SAICAR => AICAR + Fumarate, Gallus gallus" xref: Reactome:REACT_106004 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Mus musculus" xref: Reactome:REACT_115559 "adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate, Gallus gallus" xref: Reactome:REACT_1463 "SAICAR => AICAR + Fumarate, Homo sapiens" xref: Reactome:REACT_28507 "SAICAR => AICAR + Fumarate, Sus scrofa" xref: Reactome:REACT_29780 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Canis familiaris" xref: Reactome:REACT_29974 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Xenopus tropicalis" xref: Reactome:REACT_32835 "SAICAR => AICAR + Fumarate, Rattus norvegicus" xref: Reactome:REACT_41804 "SAICAR => AICAR + Fumarate, Mus musculus" xref: Reactome:REACT_80345 "SAICAR => AICAR + Fumarate, Xenopus tropicalis" xref: Reactome:REACT_80474 "SAICAR => AICAR + Fumarate, Bos taurus" xref: Reactome:REACT_80585 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Saccharomyces cerevisiae" xref: Reactome:REACT_80701 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Taeniopygia guttata" xref: Reactome:REACT_81241 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Gallus gallus" xref: Reactome:REACT_81311 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Bos taurus" xref: Reactome:REACT_83223 "SAICAR => AICAR + Fumarate, Caenorhabditis elegans" xref: Reactome:REACT_84337 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Danio rerio" xref: Reactome:REACT_85458 "SAICAR => AICAR + Fumarate, Schizosaccharomyces pombe" xref: Reactome:REACT_87024 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Drosophila melanogaster" xref: Reactome:REACT_88636 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Sus scrofa" xref: Reactome:REACT_89158 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Staphylococcus aureus N315" xref: Reactome:REACT_90078 "SAICAR => AICAR + Fumarate, Canis familiaris" xref: Reactome:REACT_95334 "SAICAR => AICAR + Fumarate, Mycobacterium tuberculosis" xref: Reactome:REACT_95492 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Rattus norvegicus" xref: Reactome:REACT_99110 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Caenorhabditis elegans" xref: Reactome:REACT_99135 "SAICAR => AICAR + Fumarate, Saccharomyces cerevisiae" xref: Reactome:REACT_99570 "SAICAR => AICAR + Fumarate, Danio rerio" xref: RHEA:16856 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004019 name: adenylosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15756] subset: gosubset_prok synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] xref: EC:6.3.4.4 xref: KEGG:R01135 xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN xref: Reactome:REACT_101481 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Xenopus tropicalis" xref: Reactome:REACT_102582 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Drosophila melanogaster" xref: Reactome:REACT_106893 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Plasmodium falciparum" xref: Reactome:REACT_108314 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Mus musculus" xref: Reactome:REACT_108485 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Bos taurus" xref: Reactome:REACT_110282 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Schizosaccharomyces pombe" xref: Reactome:REACT_110567 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Arabidopsis thaliana" xref: Reactome:REACT_110657 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Gallus gallus" xref: Reactome:REACT_115645 "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate, Gallus gallus" xref: Reactome:REACT_1719 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Homo sapiens" xref: Reactome:REACT_2217 "inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate, Mus musculus" xref: Reactome:REACT_34115 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Oryza sativa" xref: Reactome:REACT_77813 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Sus scrofa" xref: Reactome:REACT_80422 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Saccharomyces cerevisiae" xref: Reactome:REACT_81626 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Canis familiaris" xref: Reactome:REACT_81912 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Rattus norvegicus" xref: Reactome:REACT_84271 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Caenorhabditis elegans" xref: Reactome:REACT_86165 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Escherichia coli" xref: Reactome:REACT_92014 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Mycobacterium tuberculosis" xref: Reactome:REACT_93976 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Staphylococcus aureus N315" xref: Reactome:REACT_97311 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Dictyostelium discoideum" xref: Reactome:REACT_98715 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Danio rerio" xref: Reactome:REACT_99701 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Taeniopygia guttata" xref: RHEA:15756 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004020 name: adenylylsulfate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] subset: gosubset_prok synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] synonym: "adenylyl-sulfate kinase activity" EXACT [] synonym: "adenylyl-sulphate kinase activity" EXACT [] synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] synonym: "APS kinase activity" EXACT [EC:2.7.1.25] synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] xref: EC:2.7.1.25 xref: MetaCyc:ADENYLYLSULFKIN-RXN xref: Reactome:REACT_102982 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Mus musculus" xref: Reactome:REACT_106160 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Canis familiaris" xref: Reactome:REACT_107506 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Drosophila melanogaster" xref: Reactome:REACT_108569 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Bos taurus" xref: Reactome:REACT_109087 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Taeniopygia guttata" xref: Reactome:REACT_109654 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Gallus gallus" xref: Reactome:REACT_112719 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Escherichia coli" xref: Reactome:REACT_27248 "APS is phosphorylated to PAPS, Mycobacterium tuberculosis" xref: Reactome:REACT_29708 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Rattus norvegicus" xref: Reactome:REACT_30753 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Xenopus tropicalis" xref: Reactome:REACT_34307 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Sus scrofa" xref: Reactome:REACT_6792 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Homo sapiens" xref: Reactome:REACT_77453 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Arabidopsis thaliana" xref: Reactome:REACT_80762 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Oryza sativa" xref: Reactome:REACT_96385 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Caenorhabditis elegans" xref: Reactome:REACT_98813 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Danio rerio" xref: RHEA:24155 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004021 name: L-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456] subset: gosubset_prok synonym: "alanine aminotransferase activity" BROAD [] synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "ALT" RELATED [EC:2.6.1.2] synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "GPT" RELATED [EC:2.6.1.2] synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2] synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: KEGG:R00258 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN xref: Reactome:REACT_101406 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Arabidopsis thaliana" xref: Reactome:REACT_101725 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Bos taurus" xref: Reactome:REACT_102570 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Canis familiaris" xref: Reactome:REACT_104815 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Rattus norvegicus" xref: Reactome:REACT_104823 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Caenorhabditis elegans" xref: Reactome:REACT_106468 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Danio rerio" xref: Reactome:REACT_110990 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Xenopus tropicalis" xref: Reactome:REACT_196 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Homo sapiens" xref: Reactome:REACT_21263 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2], Homo sapiens" xref: Reactome:REACT_21311 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2], Homo sapiens" xref: Reactome:REACT_29599 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Saccharomyces cerevisiae" xref: Reactome:REACT_30303 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Danio rerio" xref: Reactome:REACT_31969 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Bos taurus" xref: Reactome:REACT_32776 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Mus musculus" xref: Reactome:REACT_356 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Homo sapiens" xref: Reactome:REACT_60750 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Caenorhabditis elegans" xref: Reactome:REACT_78782 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Arabidopsis thaliana" xref: Reactome:REACT_79645 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Dictyostelium discoideum" xref: Reactome:REACT_80629 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Sus scrofa" xref: Reactome:REACT_80730 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Oryza sativa" xref: Reactome:REACT_82015 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Canis familiaris" xref: Reactome:REACT_83615 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Schizosaccharomyces pombe" xref: Reactome:REACT_87728 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Rattus norvegicus" xref: Reactome:REACT_88275 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Sus scrofa" xref: Reactome:REACT_88337 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Drosophila melanogaster" xref: Reactome:REACT_89745 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Oryza sativa" xref: Reactome:REACT_91288 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Dictyostelium discoideum" xref: Reactome:REACT_91807 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Saccharomyces cerevisiae" xref: Reactome:REACT_92910 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Mus musculus" xref: Reactome:REACT_93831 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Schizosaccharomyces pombe" xref: Reactome:REACT_94700 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Drosophila melanogaster" xref: Reactome:REACT_99170 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Xenopus tropicalis" xref: RHEA:19456 is_a: GO:0047635 ! alanine-oxo-acid transaminase activity [Term] id: GO:0004022 name: alcohol dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] subset: gosubset_prok synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aldehyde dehydrogenase (NAD) activity" NARROW [] synonym: "aldo-keto reductase (NAD) activity" EXACT [] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: UM-BBD_enzymeID:e0023 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004023 name: alcohol dehydrogenase activity, metal ion-independent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004024 name: alcohol dehydrogenase activity, zinc-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok xref: Reactome:REACT_107562 "ethanol + NAD+ => acetaldehyde + NADH + H+, Gallus gallus" xref: Reactome:REACT_1431 "ethanol + NAD+ => acetaldehyde + NADH + H+, Homo sapiens" xref: Reactome:REACT_28919 "ethanol + NAD+ => acetaldehyde + NADH + H+, Danio rerio" xref: Reactome:REACT_31030 "ethanol + NAD+ => acetaldehyde + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_33588 "ethanol + NAD+ => acetaldehyde + NADH + H+, Canis familiaris" xref: Reactome:REACT_52273 "ethanol + NAD+ => acetaldehyde + NADH + H+, Sus scrofa" xref: Reactome:REACT_90358 "ethanol + NAD+ => acetaldehyde + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_90708 "ethanol + NAD+ => acetaldehyde + NADH + H+, Mus musculus" xref: Reactome:REACT_92592 "ethanol + NAD+ => acetaldehyde + NADH + H+, Bos taurus" is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004025 name: alcohol dehydrogenase activity, iron-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004026 name: alcohol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] synonym: "AATASE activity" EXACT [EC:2.3.1.84] synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: gosubset_prok synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:REACT_101584 "cholesterol + PAPS => cholesterol sulfate + PAP, Canis familiaris" xref: Reactome:REACT_34593 "cholesterol + PAPS => cholesterol sulfate + PAP, Gallus gallus" xref: Reactome:REACT_59193 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_6881 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6957 "cholesterol + PAPS => cholesterol sulfate + PAP, Homo sapiens" xref: Reactome:REACT_79006 "cholesterol + PAPS => cholesterol sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_80452 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Mus musculus" xref: Reactome:REACT_94728 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_95422 "cholesterol + PAPS => cholesterol sulfate + PAP, Mus musculus" xref: Reactome:REACT_96417 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Rattus norvegicus" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004028 name: 3-chloroallyl aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] subset: gosubset_prok xref: EC:1.2.1.- xref: Reactome:REACT_100428 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Gallus gallus" xref: Reactome:REACT_102182 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_102594 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Escherichia coli" xref: Reactome:REACT_104268 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_220 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Homo sapiens" xref: Reactome:REACT_32159 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Canis familiaris" xref: Reactome:REACT_54249 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_78707 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_80702 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Sus scrofa" xref: Reactome:REACT_86482 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Bos taurus" xref: Reactome:REACT_99167 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Mus musculus" xref: Reactome:REACT_99233 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Danio rerio" xref: UM-BBD_enzymeID:e0432 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004029 name: aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] subset: gosubset_prok synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] xref: EC:1.2.1.3 xref: MetaCyc:ALDHDEHYDROG-RXN xref: Reactome:REACT_100473 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Canis familiaris" xref: Reactome:REACT_103621 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Canis familiaris" xref: Reactome:REACT_104849 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Oryza sativa" xref: Reactome:REACT_105050 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Arabidopsis thaliana" xref: Reactome:REACT_105669 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Drosophila melanogaster" xref: Reactome:REACT_105847 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Arabidopsis thaliana" xref: Reactome:REACT_105932 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Oryza sativa" xref: Reactome:REACT_1080 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Homo sapiens" xref: Reactome:REACT_110301 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Caenorhabditis elegans" xref: Reactome:REACT_110943 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Gallus gallus" xref: Reactome:REACT_112729 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Dictyostelium discoideum" xref: Reactome:REACT_112808 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Escherichia coli" xref: Reactome:REACT_113173 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Rattus norvegicus" xref: Reactome:REACT_113214 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Dictyostelium discoideum" xref: Reactome:REACT_113740 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Mycobacterium tuberculosis" xref: Reactome:REACT_114032 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Escherichia coli" xref: Reactome:REACT_114609 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Mycobacterium tuberculosis" xref: Reactome:REACT_115403 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Dictyostelium discoideum" xref: Reactome:REACT_15407 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Homo sapiens" xref: Reactome:REACT_16919 "pristanal + NAD+ => pristanate + NADH + H+, Homo sapiens" xref: Reactome:REACT_2127 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Homo sapiens" xref: Reactome:REACT_30242 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Bos taurus" xref: Reactome:REACT_30317 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Drosophila melanogaster" xref: Reactome:REACT_30455 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Mus musculus" xref: Reactome:REACT_31589 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Taeniopygia guttata" xref: Reactome:REACT_34252 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Mus musculus" xref: Reactome:REACT_78762 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Arabidopsis thaliana" xref: Reactome:REACT_80267 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Danio rerio" xref: Reactome:REACT_81293 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Sus scrofa" xref: Reactome:REACT_83193 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Taeniopygia guttata" xref: Reactome:REACT_83627 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Canis familiaris" xref: Reactome:REACT_83939 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Mus musculus" xref: Reactome:REACT_84001 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Rattus norvegicus" xref: Reactome:REACT_85596 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Rattus norvegicus" xref: Reactome:REACT_86116 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Sus scrofa" xref: Reactome:REACT_86294 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Caenorhabditis elegans" xref: Reactome:REACT_86661 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Bos taurus" xref: Reactome:REACT_87336 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Danio rerio" xref: Reactome:REACT_88233 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Xenopus tropicalis" xref: Reactome:REACT_89302 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Xenopus tropicalis" xref: Reactome:REACT_89718 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Xenopus tropicalis" xref: Reactome:REACT_91587 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Taeniopygia guttata" xref: Reactome:REACT_91840 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Gallus gallus" xref: Reactome:REACT_93677 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Gallus gallus" xref: Reactome:REACT_97751 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Bos taurus" xref: Reactome:REACT_99086 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Oryza sativa" xref: RHEA:16188 xref: UM-BBD_enzymeID:e0024 xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+) is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004030 name: aldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] subset: gosubset_prok synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] synonym: "ALDH" RELATED [EC:1.2.1.5] xref: EC:1.2.1.5 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004031 name: aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1] subset: gosubset_prok synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] xref: EC:1.2.3.1 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN xref: RHEA:16832 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004032 name: alditol:NADP+ 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] subset: gosubset_prok synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] xref: EC:1.1.1.21 xref: KEGG:R02820 "alditol:NADP+ 1-oxidoreductase" xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN xref: Reactome:REACT_105330 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Xenopus tropicalis" xref: Reactome:REACT_107111 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Drosophila melanogaster" xref: Reactome:REACT_110163 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Mus musculus" xref: Reactome:REACT_112305 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Arabidopsis thaliana" xref: Reactome:REACT_112358 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Dictyostelium discoideum" xref: Reactome:REACT_114284 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Oryza sativa" xref: Reactome:REACT_31934 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Bos taurus" xref: Reactome:REACT_32005 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Gallus gallus" xref: Reactome:REACT_32567 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Danio rerio" xref: Reactome:REACT_32715 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Canis familiaris" xref: Reactome:REACT_91048 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Sus scrofa" xref: Reactome:REACT_92726 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Saccharomyces cerevisiae" xref: Reactome:REACT_94458 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Rattus norvegicus" xref: Reactome:REACT_9986 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Homo sapiens" is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0004033 name: aldo-keto reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai] subset: gosubset_prok synonym: "alcohol dehydrogenase (NADP+) activity" NARROW [] synonym: "aldo-keto reductase (NADP+) activity" EXACT [] synonym: "aldo-keto reductase activity" EXACT [] synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] xref: EC:1.1.1.- xref: Reactome:REACT_10008 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Homo sapiens" xref: Reactome:REACT_10018 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Homo sapiens" xref: Reactome:REACT_10038 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Homo sapiens" xref: Reactome:REACT_10044 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Homo sapiens" xref: Reactome:REACT_100460 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Canis familiaris" xref: Reactome:REACT_10048 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Homo sapiens" xref: Reactome:REACT_10054 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Homo sapiens" xref: Reactome:REACT_10068 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Homo sapiens" xref: Reactome:REACT_10086 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Homo sapiens" xref: Reactome:REACT_10102 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Homo sapiens" xref: Reactome:REACT_10120 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Homo sapiens" xref: Reactome:REACT_10131 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Homo sapiens" xref: Reactome:REACT_101534 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Bos taurus" xref: Reactome:REACT_101629 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Rattus norvegicus" xref: Reactome:REACT_101931 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Mus musculus" xref: Reactome:REACT_104573 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Mus musculus" xref: Reactome:REACT_104664 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_104786 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Mus musculus" xref: Reactome:REACT_105193 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Rattus norvegicus" xref: Reactome:REACT_106036 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Xenopus tropicalis" xref: Reactome:REACT_106194 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Mus musculus" xref: Reactome:REACT_106928 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_108439 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Mus musculus" xref: Reactome:REACT_108757 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_110383 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_110687 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Mus musculus" xref: Reactome:REACT_110920 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Canis familiaris" xref: Reactome:REACT_11100 "Reduction of semidehydroascorbate to ascorbate, Homo sapiens" xref: Reactome:REACT_111993 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_112004 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_112078 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Drosophila melanogaster" xref: Reactome:REACT_112094 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_112136 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Drosophila melanogaster" xref: Reactome:REACT_112164 "Reduction of semidehydroascorbate to ascorbate, Dictyostelium discoideum" xref: Reactome:REACT_112352 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Dictyostelium discoideum" xref: Reactome:REACT_112380 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Oryza sativa" xref: Reactome:REACT_112446 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Arabidopsis thaliana" xref: Reactome:REACT_112477 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Drosophila melanogaster" xref: Reactome:REACT_112538 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Oryza sativa" xref: Reactome:REACT_112546 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Arabidopsis thaliana" xref: Reactome:REACT_112547 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Arabidopsis thaliana" xref: Reactome:REACT_112635 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Dictyostelium discoideum" xref: Reactome:REACT_112765 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Oryza sativa" xref: Reactome:REACT_112786 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Drosophila melanogaster" xref: Reactome:REACT_112971 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Drosophila melanogaster" xref: Reactome:REACT_113067 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Dictyostelium discoideum" xref: Reactome:REACT_113108 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_113453 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Oryza sativa" xref: Reactome:REACT_113482 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Drosophila melanogaster" xref: Reactome:REACT_113545 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_113590 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_113657 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Arabidopsis thaliana" xref: Reactome:REACT_113694 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Drosophila melanogaster" xref: Reactome:REACT_113742 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Dictyostelium discoideum" xref: Reactome:REACT_113762 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Oryza sativa" xref: Reactome:REACT_113791 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_113879 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Oryza sativa" xref: Reactome:REACT_113982 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Arabidopsis thaliana" xref: Reactome:REACT_114182 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_114303 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Arabidopsis thaliana" xref: Reactome:REACT_114413 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Oryza sativa" xref: Reactome:REACT_114451 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Oryza sativa" xref: Reactome:REACT_114529 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Drosophila melanogaster" xref: Reactome:REACT_114561 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Oryza sativa" xref: Reactome:REACT_114574 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Dictyostelium discoideum" xref: Reactome:REACT_114601 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_114670 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_114682 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Oryza sativa" xref: Reactome:REACT_114688 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Drosophila melanogaster" xref: Reactome:REACT_114788 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Oryza sativa" xref: Reactome:REACT_114934 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Oryza sativa" xref: Reactome:REACT_114943 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_114951 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Dictyostelium discoideum" xref: Reactome:REACT_115178 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_115352 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_115369 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_115407 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_28191 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Saccharomyces cerevisiae" xref: Reactome:REACT_28575 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Saccharomyces cerevisiae" xref: Reactome:REACT_28637 "Reduction of semidehydroascorbate to ascorbate, Caenorhabditis elegans" xref: Reactome:REACT_28655 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_28677 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Xenopus tropicalis" xref: Reactome:REACT_28850 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Canis familiaris" xref: Reactome:REACT_28933 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Xenopus tropicalis" xref: Reactome:REACT_29682 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Mus musculus" xref: Reactome:REACT_30872 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Gallus gallus" xref: Reactome:REACT_31905 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_31910 "Reduction of semidehydroascorbate to ascorbate, Canis familiaris" xref: Reactome:REACT_32080 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Gallus gallus" xref: Reactome:REACT_32937 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Canis familiaris" xref: Reactome:REACT_33063 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Bos taurus" xref: Reactome:REACT_33464 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_77287 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Mus musculus" xref: Reactome:REACT_79323 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_79627 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Mus musculus" xref: Reactome:REACT_79990 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Xenopus tropicalis" xref: Reactome:REACT_81316 "Reduction of semidehydroascorbate to ascorbate, Sus scrofa" xref: Reactome:REACT_82437 "Reduction of semidehydroascorbate to ascorbate, Danio rerio" xref: Reactome:REACT_82926 "Reduction of semidehydroascorbate to ascorbate, Mus musculus" xref: Reactome:REACT_82973 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Bos taurus" xref: Reactome:REACT_82990 "Reduction of semidehydroascorbate to ascorbate, Taeniopygia guttata" xref: Reactome:REACT_83001 "Reduction of semidehydroascorbate to ascorbate, Gallus gallus" xref: Reactome:REACT_83433 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_83731 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Canis familiaris" xref: Reactome:REACT_84395 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_84566 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Taeniopygia guttata" xref: Reactome:REACT_84799 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Bos taurus" xref: Reactome:REACT_85106 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_85206 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_85231 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Saccharomyces cerevisiae" xref: Reactome:REACT_85587 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Saccharomyces cerevisiae" xref: Reactome:REACT_85900 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_86109 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Taeniopygia guttata" xref: Reactome:REACT_86399 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Rattus norvegicus" xref: Reactome:REACT_87189 "Reduction of semidehydroascorbate to ascorbate, Bos taurus" xref: Reactome:REACT_87397 "Reduction of semidehydroascorbate to ascorbate, Drosophila melanogaster" xref: Reactome:REACT_87734 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Saccharomyces cerevisiae" xref: Reactome:REACT_89410 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Xenopus tropicalis" xref: Reactome:REACT_90460 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Xenopus tropicalis" xref: Reactome:REACT_91267 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Bos taurus" xref: Reactome:REACT_91578 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Taeniopygia guttata" xref: Reactome:REACT_92005 "Reduction of semidehydroascorbate to ascorbate, Rattus norvegicus" xref: Reactome:REACT_92354 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Mus musculus" xref: Reactome:REACT_92749 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Gallus gallus" xref: Reactome:REACT_92830 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Bos taurus" xref: Reactome:REACT_93550 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Mus musculus" xref: Reactome:REACT_93907 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Canis familiaris" xref: Reactome:REACT_94094 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_94919 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Xenopus tropicalis" xref: Reactome:REACT_95441 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Mus musculus" xref: Reactome:REACT_95886 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Saccharomyces cerevisiae" xref: Reactome:REACT_96852 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_97815 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Xenopus tropicalis" xref: Reactome:REACT_98175 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Xenopus tropicalis" xref: Reactome:REACT_98269 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Gallus gallus" xref: Reactome:REACT_98473 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Gallus gallus" xref: Reactome:REACT_98695 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Gallus gallus" xref: Reactome:REACT_99599 "Reduction of semidehydroascorbate to ascorbate, Xenopus tropicalis" xref: Reactome:REACT_9972 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Homo sapiens" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004034 name: aldose 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] subset: gosubset_prok synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] synonym: "mutarotase activity" RELATED [EC:5.1.3.3] xref: EC:5.1.3.3 xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN xref: RHEA:10267 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004035 name: alkaline phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] subset: gosubset_prok synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] xref: EC:3.1.3.1 xref: MetaCyc:ALKAPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004037 name: allantoicase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11019] subset: gosubset_prok synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] synonym: "allantoine amidinohydrolase activity" EXACT [] xref: EC:3.5.3.4 xref: KEGG:R02422 xref: MetaCyc:ALLANTOICASE-RXN xref: RHEA:11019 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004038 name: allantoinase activity namespace: molecular_function def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] subset: gosubset_prok synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] xref: EC:3.5.2.5 xref: MetaCyc:ALLANTOINASE-RXN xref: RHEA:17032 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004039 name: allophanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19032] subset: gosubset_prok synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] xref: EC:3.5.1.54 xref: KEGG:R00005 xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN xref: RHEA:19032 xref: UM-BBD_reactionID:r0848 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004040 name: amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] subset: gosubset_prok synonym: "acetamidase activity" EXACT [] synonym: "acylamidase activity" EXACT [EC:3.5.1.4] synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "acylase activity" EXACT [EC:3.5.1.4] synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: MetaCyc:AMIDASE-RXN xref: UM-BBD_enzymeID:e0068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004042 name: acetyl-CoA:L-glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24295] subset: gosubset_prok synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] synonym: "AGAS" RELATED [EC:2.3.1.1] synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] xref: EC:2.3.1.1 xref: KEGG:R00259 xref: MetaCyc:N-ACETYLTRANSFER-RXN xref: Reactome:REACT_102238 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Dictyostelium discoideum" xref: Reactome:REACT_108325 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Mus musculus" xref: Reactome:REACT_2139 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Homo sapiens" xref: Reactome:REACT_29654 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Rattus norvegicus" xref: Reactome:REACT_31801 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Canis familiaris" xref: Reactome:REACT_81010 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Saccharomyces cerevisiae" xref: Reactome:REACT_81256 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Bos taurus" xref: Reactome:REACT_85183 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_89124 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Xenopus tropicalis" xref: Reactome:REACT_94579 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Sus scrofa" xref: Reactome:REACT_99960 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Danio rerio" xref: RHEA:24295 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004043 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] subset: gosubset_prok synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: Reactome:REACT_110440 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Arabidopsis thaliana" xref: Reactome:REACT_1540 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Homo sapiens" xref: Reactome:REACT_34232 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Danio rerio" xref: Reactome:REACT_34396 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Mycobacterium tuberculosis" xref: Reactome:REACT_77435 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Oryza sativa" xref: Reactome:REACT_79544 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_80215 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_80324 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Canis familiaris" xref: Reactome:REACT_81404 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Gallus gallus" xref: Reactome:REACT_84541 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Sus scrofa" xref: Reactome:REACT_86291 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_88752 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_92070 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_92791 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Bos taurus" xref: Reactome:REACT_95793 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_97958 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Mus musculus" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004044 name: amidophosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908] subset: gosubset_prok synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] xref: EC:2.4.2.14 xref: KEGG:R01072 xref: MetaCyc:PRPPAMIDOTRANS-RXN xref: Reactome:REACT_102786 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Arabidopsis thaliana" xref: Reactome:REACT_103149 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Sus scrofa" xref: Reactome:REACT_106474 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Dictyostelium discoideum" xref: Reactome:REACT_116094 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate, Gallus gallus" xref: Reactome:REACT_30841 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Staphylococcus aureus N315" xref: Reactome:REACT_32820 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Escherichia coli" xref: Reactome:REACT_33476 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Xenopus tropicalis" xref: Reactome:REACT_740 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Homo sapiens" xref: Reactome:REACT_76986 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Danio rerio" xref: Reactome:REACT_78155 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Bos taurus" xref: Reactome:REACT_80319 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Mus musculus" xref: Reactome:REACT_84289 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Canis familiaris" xref: Reactome:REACT_85912 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Gallus gallus" xref: Reactome:REACT_86712 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_87917 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Oryza sativa" xref: Reactome:REACT_90579 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_93984 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Taeniopygia guttata" xref: Reactome:REACT_94540 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_95631 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_98124 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Caenorhabditis elegans" xref: Reactome:REACT_99042 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Saccharomyces cerevisiae" xref: RHEA:14908 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004045 name: aminoacyl-tRNA hydrolase activity namespace: molecular_function alt_id: GO:0019850 alt_id: GO:0019851 def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] subset: gosubset_prok synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242] synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004046 name: aminoacylase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] subset: gosubset_prok synonym: "acylase I activity" NARROW [EC:3.5.1.14] synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] synonym: "benzamidase activity" RELATED [EC:3.5.1.14] synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] synonym: "hippurase activity" EXACT [EC:3.5.1.14] synonym: "histozyme activity" RELATED [EC:3.5.1.14] synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] xref: EC:3.5.1.14 xref: MetaCyc:AMINOACYLASE-RXN xref: RHEA:15568 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004047 name: aminomethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] subset: gosubset_prok synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "T-protein" RELATED [EC:2.1.2.10] synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] xref: EC:2.1.2.10 xref: MetaCyc:GCVT-RXN xref: RHEA:16948 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0004048 name: anthranilate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11771] subset: gosubset_prok synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] synonym: "PRT" RELATED [EC:2.4.2.18] xref: EC:2.4.2.18 xref: KEGG:R01073 xref: MetaCyc:PRTRANS-RXN xref: RHEA:11771 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004049 name: anthranilate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] subset: gosubset_prok synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] xref: EC:4.1.3.27 xref: MetaCyc:ANTHRANSYN-RXN xref: RHEA:21735 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004050 name: apyrase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. is_obsolete: true consider: GO:0017110 consider: GO:0017111 [Term] id: GO:0004051 name: arachidonate 5-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] subset: gosubset_prok synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] xref: EC:1.13.11.34 xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN xref: Reactome:REACT_101081 "Oxidation of arachidonic acid to 5-HpETE, Sus scrofa" xref: Reactome:REACT_102776 "Dehydration of 5-HpETE to leukotriene A4, Bos taurus" xref: Reactome:REACT_104725 "Dehydration of 5-HpETE to leukotriene A4, Gallus gallus" xref: Reactome:REACT_107795 "Oxidation of arachidonic acid to 5-HpETE, Gallus gallus" xref: Reactome:REACT_107991 "Dehydration of 5-HpETE to leukotriene A4, Rattus norvegicus" xref: Reactome:REACT_109247 "Oxidation of arachidonic acid to 5-HpETE, Rattus norvegicus" xref: Reactome:REACT_110901 "Oxidation of arachidonic acid to 5-HpETE, Danio rerio" xref: Reactome:REACT_113814 "Dehydration of 5-HpETE to leukotriene A4, Dictyostelium discoideum" xref: Reactome:REACT_115370 "Oxidation of arachidonic acid to 5-HpETE, Dictyostelium discoideum" xref: Reactome:REACT_15337 "Oxidation of arachidonic acid to 5-HpETE, Homo sapiens" xref: Reactome:REACT_15453 "Dehydration of 5-HpETE to leukotriene A4, Homo sapiens" xref: Reactome:REACT_28749 "Oxidation of arachidonic acid to 5-HpETE, Canis familiaris" xref: Reactome:REACT_76963 "Dehydration of 5-HpETE to leukotriene A4, Canis familiaris" xref: Reactome:REACT_77245 "Oxidation of arachidonic acid to 5-HpETE, Taeniopygia guttata" xref: Reactome:REACT_78626 "Oxidation of arachidonic acid to 5-HpETE, Xenopus tropicalis" xref: Reactome:REACT_79548 "Dehydration of 5-HpETE to leukotriene A4, Danio rerio" xref: Reactome:REACT_80928 "Oxidation of arachidonic acid to 5-HpETE, Mus musculus" xref: Reactome:REACT_84095 "Dehydration of 5-HpETE to leukotriene A4, Taeniopygia guttata" xref: Reactome:REACT_84894 "Dehydration of 5-HpETE to leukotriene A4, Sus scrofa" xref: Reactome:REACT_87806 "Dehydration of 5-HpETE to leukotriene A4, Xenopus tropicalis" xref: Reactome:REACT_90210 "Oxidation of arachidonic acid to 5-HpETE, Bos taurus" xref: Reactome:REACT_99738 "Dehydration of 5-HpETE to leukotriene A4, Mus musculus" xref: RHEA:24751 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004052 name: arachidonate 12-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10431] synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] xref: EC:1.13.11.31 xref: KEGG:R01596 xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN xref: RHEA:10431 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004053 name: arginase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] subset: gosubset_prok synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] synonym: "canavanase activity" EXACT [EC:3.5.3.1] synonym: "L-arginase activity" EXACT [EC:3.5.3.1] synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] xref: EC:3.5.3.1 xref: MetaCyc:ARGINASE-RXN xref: Reactome:REACT_104545 "arginine + H2O => ornithine + urea [ARG1], Mus musculus" xref: Reactome:REACT_105138 "arginine + H2O => ornithine + urea [ARG1], Saccharomyces cerevisiae" xref: Reactome:REACT_105399 "arginine + H2O => ornithine + urea [ARG1], Rattus norvegicus" xref: Reactome:REACT_112789 "arginine + H2O => ornithine + urea [ARG1], Caenorhabditis elegans" xref: Reactome:REACT_115584 "arginine + H2O => ornithine + urea, Gallus gallus" xref: Reactome:REACT_21325 "arginine + H2O => ornithine + urea [ARG2], Homo sapiens" xref: Reactome:REACT_29262 "arginine + H2O => ornithine + urea [ARG1], Drosophila melanogaster" xref: Reactome:REACT_394 "arginine + H2O => ornithine + urea [ARG1], Homo sapiens" xref: Reactome:REACT_80504 "arginine + H2O => ornithine + urea [ARG1], Sus scrofa" xref: Reactome:REACT_83897 "arginine + H2O => ornithine + urea [ARG1], Plasmodium falciparum" xref: Reactome:REACT_84916 "arginine + H2O => ornithine + urea [ARG1], Canis familiaris" xref: Reactome:REACT_94417 "arginine + H2O => ornithine + urea [ARG1], Xenopus tropicalis" xref: Reactome:REACT_94917 "arginine + H2O => ornithine + urea [ARG1], Schizosaccharomyces pombe" xref: Reactome:REACT_99000 "arginine + H2O => ornithine + urea [ARG1], Bos taurus" xref: Reactome:REACT_99109 "arginine + H2O => ornithine + urea [ARG1], Staphylococcus aureus N315" xref: Reactome:REACT_99872 "arginine + H2O => ornithine + urea [ARG1], Danio rerio" xref: RHEA:20572 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004054 name: arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22943] synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] xref: EC:2.7.3.3 xref: KEGG:R00554 xref: MetaCyc:ARGININE-KINASE-RXN xref: RHEA:22943 is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004055 name: argininosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] subset: gosubset_prok synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] xref: EC:6.3.4.5 xref: MetaCyc:ARGSUCCINSYN-RXN xref: Reactome:REACT_102781 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Canis familiaris" xref: Reactome:REACT_102882 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_110988 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Arabidopsis thaliana" xref: Reactome:REACT_113640 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Gallus gallus" xref: Reactome:REACT_115870 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Gallus gallus" xref: Reactome:REACT_29799 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_31033 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_482 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Homo sapiens" xref: Reactome:REACT_77511 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Danio rerio" xref: Reactome:REACT_78098 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Oryza sativa" xref: Reactome:REACT_82273 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_85713 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Sus scrofa" xref: Reactome:REACT_93966 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_94014 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Bos taurus" xref: Reactome:REACT_94088 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Taeniopygia guttata" xref: Reactome:REACT_95275 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Xenopus tropicalis" xref: Reactome:REACT_98246 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Mus musculus" xref: Reactome:REACT_98815 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Escherichia coli" xref: Reactome:REACT_99835 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Staphylococcus aureus N315" xref: RHEA:10935 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004056 name: argininosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] subset: gosubset_prok synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] xref: EC:4.3.2.1 xref: MetaCyc:ARGSUCCINLYA-RXN xref: Reactome:REACT_105702 "argininosuccinate <=> fumarate + arginine, Xenopus tropicalis" xref: Reactome:REACT_107201 "argininosuccinate <=> fumarate + arginine, Taeniopygia guttata" xref: Reactome:REACT_107341 "argininosuccinate <=> fumarate + arginine, Rattus norvegicus" xref: Reactome:REACT_107497 "argininosuccinate <=> fumarate + arginine, Sus scrofa" xref: Reactome:REACT_108281 "argininosuccinate <=> fumarate + arginine, Canis familiaris" xref: Reactome:REACT_110613 "argininosuccinate <=> fumarate + arginine, Saccharomyces cerevisiae" xref: Reactome:REACT_113182 "argininosuccinate <=> fumarate + arginine, Staphylococcus aureus N315" xref: Reactome:REACT_114192 "argininosuccinate <=> fumarate + arginine, Arabidopsis thaliana" xref: Reactome:REACT_114884 "argininosuccinate <=> fumarate + arginine, Escherichia coli" xref: Reactome:REACT_115252 "argininosuccinate <=> fumarate + arginine, Oryza sativa" xref: Reactome:REACT_116009 "argininosuccinate <=> fumarate + arginine, Gallus gallus" xref: Reactome:REACT_1378 "argininosuccinate <=> fumarate + arginine, Homo sapiens" xref: Reactome:REACT_79360 "argininosuccinate <=> fumarate + arginine, Schizosaccharomyces pombe" xref: Reactome:REACT_79752 "argininosuccinate <=> fumarate + arginine, Drosophila melanogaster" xref: Reactome:REACT_83325 "argininosuccinate <=> fumarate + arginine, Gallus gallus" xref: Reactome:REACT_92799 "argininosuccinate <=> fumarate + arginine, Mycobacterium tuberculosis" xref: Reactome:REACT_94002 "argininosuccinate <=> fumarate + arginine, Danio rerio" xref: Reactome:REACT_98490 "argininosuccinate <=> fumarate + arginine, Mus musculus" xref: Reactome:REACT_98521 "argininosuccinate <=> fumarate + arginine, Bos taurus" xref: RHEA:24023 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004057 name: arginyltransferase activity namespace: molecular_function alt_id: GO:0042172 def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] subset: gosubset_prok synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: MetaCyc:ARGINYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0004058 name: aromatic-L-amino-acid decarboxylase activity namespace: molecular_function alt_id: GO:0016400 def: "Catalysis of the reaction: L-tryptophan = tryptamine + CO2." [EC:4.1.1.28] synonym: "5-hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "L-DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "tryptophan decarboxylase activity" EXACT [EC:4.1.1.28] xref: EC:4.1.1.28 xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN xref: Reactome:REACT_102788 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Rattus norvegicus" xref: Reactome:REACT_104092 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Bos taurus" xref: Reactome:REACT_107239 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Xenopus tropicalis" xref: Reactome:REACT_109359 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Canis familiaris" xref: Reactome:REACT_110116 "Dopa is decarboxylated to dopamine, Arabidopsis thaliana" xref: Reactome:REACT_110361 "Dopa is decarboxylated to dopamine, Taeniopygia guttata" xref: Reactome:REACT_15382 "Dopa is decarboxylated to dopamine, Homo sapiens" xref: Reactome:REACT_15546 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Homo sapiens" xref: Reactome:REACT_29601 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Taeniopygia guttata" xref: Reactome:REACT_32557 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Drosophila melanogaster" xref: Reactome:REACT_32559 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Sus scrofa" xref: Reactome:REACT_32861 "Dopa is decarboxylated to dopamine, Danio rerio" xref: Reactome:REACT_40024 "Dopa is decarboxylated to dopamine, Gallus gallus" xref: Reactome:REACT_77761 "Dopa is decarboxylated to dopamine, Xenopus tropicalis" xref: Reactome:REACT_78186 "Dopa is decarboxylated to dopamine, Canis familiaris" xref: Reactome:REACT_82232 "Dopa is decarboxylated to dopamine, Rattus norvegicus" xref: Reactome:REACT_85510 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Arabidopsis thaliana" xref: Reactome:REACT_87158 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Mus musculus" xref: Reactome:REACT_92081 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Danio rerio" xref: Reactome:REACT_93251 "Dopa is decarboxylated to dopamine, Bos taurus" xref: Reactome:REACT_96152 "Dopa is decarboxylated to dopamine, Oryza sativa" xref: Reactome:REACT_96639 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Oryza sativa" xref: Reactome:REACT_97213 "Dopa is decarboxylated to dopamine, Mus musculus" xref: Reactome:REACT_97677 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Gallus gallus" xref: Reactome:REACT_99387 "Dopa is decarboxylated to dopamine, Drosophila melanogaster" xref: Reactome:REACT_99826 "Dopa is decarboxylated to dopamine, Sus scrofa" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004059 name: aralkylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] synonym: "AANAT activity" EXACT [EC:2.3.1.87] synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:REACT_102250 "N-acetylation of serotonin, Rattus norvegicus" xref: Reactome:REACT_102805 "N-acetylation of serotonin, Gallus gallus" xref: Reactome:REACT_104511 "N-acetylation of serotonin, Xenopus tropicalis" xref: Reactome:REACT_15290 "N-acetylation of serotonin, Homo sapiens" xref: Reactome:REACT_29536 "N-acetylation of serotonin, Mus musculus" xref: Reactome:REACT_33625 "N-acetylation of serotonin, Canis familiaris" xref: Reactome:REACT_81480 "N-acetylation of serotonin, Danio rerio" xref: Reactome:REACT_85448 "N-acetylation of serotonin, Taeniopygia guttata" xref: Reactome:REACT_86020 "N-acetylation of serotonin, Sus scrofa" xref: Reactome:REACT_92297 "N-acetylation of serotonin, Bos taurus" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004060 name: arylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] subset: gosubset_prok synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] xref: EC:2.3.1.5 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:REACT_104415 "NAT2 acetylation, Sus scrofa" xref: Reactome:REACT_105583 "NAT2 acetylation, Taeniopygia guttata" xref: Reactome:REACT_108176 "NAT1 acetylation, Sus scrofa" xref: Reactome:REACT_113266 "NAT1 acetylation, Staphylococcus aureus N315" xref: Reactome:REACT_115264 "NAT2 acetylation, Staphylococcus aureus N315" xref: Reactome:REACT_28496 "NAT2 acetylation, Danio rerio" xref: Reactome:REACT_29504 "NAT2 acetylation, Mycobacterium tuberculosis" xref: Reactome:REACT_32809 "NAT2 acetylation, Escherichia coli" xref: Reactome:REACT_33982 "NAT1 acetylation, Gallus gallus" xref: Reactome:REACT_6832 "NAT1 acetylation, Homo sapiens" xref: Reactome:REACT_6944 "NAT2 acetylation, Homo sapiens" xref: Reactome:REACT_82229 "NAT1 acetylation, Escherichia coli" xref: Reactome:REACT_83190 "NAT2 acetylation, Bos taurus" xref: Reactome:REACT_83509 "NAT2 acetylation, Rattus norvegicus" xref: Reactome:REACT_83772 "NAT1 acetylation, Rattus norvegicus" xref: Reactome:REACT_84287 "NAT1 acetylation, Bos taurus" xref: Reactome:REACT_85456 "NAT2 acetylation, Mus musculus" xref: Reactome:REACT_85532 "NAT1 acetylation, Danio rerio" xref: Reactome:REACT_88074 "NAT1 acetylation, Mus musculus" xref: Reactome:REACT_91678 "NAT2 acetylation, Gallus gallus" xref: Reactome:REACT_91780 "NAT1 acetylation, Mycobacterium tuberculosis" xref: Reactome:REACT_99622 "NAT1 acetylation, Taeniopygia guttata" xref: UM-BBD_enzymeID:e0341 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004061 name: arylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] subset: gosubset_prok synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] synonym: "formamidase I" RELATED [EC:3.5.1.9] synonym: "formamidase II" RELATED [EC:3.5.1.9] synonym: "formylase activity" EXACT [EC:3.5.1.9] synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] xref: EC:3.5.1.9 xref: MetaCyc:ARYLFORMAMIDASE-RXN xref: Reactome:REACT_101177 "N-formylkynurenine + H2O => kynurenine + formate, Danio rerio" xref: Reactome:REACT_101720 "N-formylkynurenine + H2O => kynurenine + formate, Drosophila melanogaster" xref: Reactome:REACT_105730 "N-formylkynurenine + H2O => kynurenine + formate, Xenopus tropicalis" xref: Reactome:REACT_106733 "N-formylkynurenine + H2O => kynurenine + formate, Taeniopygia guttata" xref: Reactome:REACT_110747 "N-formylkynurenine + H2O => kynurenine + formate, Bos taurus" xref: Reactome:REACT_1187 "N-formylkynurenine + H2O => kynurenine + formate [mouse], Mus musculus" xref: Reactome:REACT_1804 "N-formylkynurenine + H2O => kynurenine + formate, Homo sapiens" xref: Reactome:REACT_31432 "N-formylkynurenine + H2O => kynurenine + formate, Gallus gallus" xref: Reactome:REACT_46660 "N-formylkynurenine + H2O => kynurenine + formate, Caenorhabditis elegans" xref: Reactome:REACT_97680 "N-formylkynurenine + H2O => kynurenine + formate, Canis familiaris" xref: RHEA:13012 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: gosubset_prok synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:REACT_101593 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Drosophila melanogaster" xref: Reactome:REACT_101626 "Acetaminophen can form an O- sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_103168 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Bos taurus" xref: Reactome:REACT_103360 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Danio rerio" xref: Reactome:REACT_103392 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Gallus gallus" xref: Reactome:REACT_103811 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_104618 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Bos taurus" xref: Reactome:REACT_105302 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_105483 "Phenol can form a sulfate conjugate, Mus musculus" xref: Reactome:REACT_106988 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Bos taurus" xref: Reactome:REACT_107852 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_109219 "Phenol can form a sulfate conjugate, Canis familiaris" xref: Reactome:REACT_112861 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_113420 "Dopamine can form an O-sulfate conjugate, Danio rerio" xref: Reactome:REACT_113755 "Acetaminophen can form an O- sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_113826 "Acetaminophen can form an O- sulfate conjugate, Danio rerio" xref: Reactome:REACT_114350 "Phenol can form a sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_114511 "Phenol can form a sulfate conjugate, Danio rerio" xref: Reactome:REACT_114894 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Danio rerio" xref: Reactome:REACT_115246 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_115272 "Dopamine can form an O-sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_28338 "Acetaminophen can form an O- sulfate conjugate, Canis familiaris" xref: Reactome:REACT_28779 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Mus musculus" xref: Reactome:REACT_30659 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_31265 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Canis familiaris" xref: Reactome:REACT_31366 "Phenol can form a sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_32021 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Bos taurus" xref: Reactome:REACT_32963 "Dopamine can form an O-sulfate conjugate, Canis familiaris" xref: Reactome:REACT_33894 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_34807 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Danio rerio" xref: Reactome:REACT_6722 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6740 "Dopamine can form an O-sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6765 "Acetaminophen can form an O- sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6855 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6868 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6897 "Phenol can form a sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6961 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_77729 "Dopamine can form an O-sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_78668 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_80310 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Canis familiaris" xref: Reactome:REACT_80654 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Mus musculus" xref: Reactome:REACT_80880 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Sus scrofa" xref: Reactome:REACT_81976 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_83825 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Mus musculus" xref: Reactome:REACT_83936 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_84713 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_87537 "Acetaminophen can form an O- sulfate conjugate, Bos taurus" xref: Reactome:REACT_88863 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Mus musculus" xref: Reactome:REACT_89258 "Dopamine can form an O-sulfate conjugate, Mus musculus" xref: Reactome:REACT_89426 "Dopamine can form an O-sulfate conjugate, Bos taurus" xref: Reactome:REACT_90170 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_90269 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Danio rerio" xref: Reactome:REACT_90981 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_91386 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Sus scrofa" xref: Reactome:REACT_91525 "Acetaminophen can form an O- sulfate conjugate, Mus musculus" xref: Reactome:REACT_91946 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_92808 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_94928 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Drosophila melanogaster" xref: Reactome:REACT_95232 "Phenol can form a sulfate conjugate, Bos taurus" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004063 name: aryldialkylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] xref: EC:3.1.8.1 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN xref: UM-BBD_enzymeID:e0054 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004064 name: arylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.1.2] synonym: "aromatic esterase" NARROW [EC:3.1.1.2] synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: MetaCyc:ARYLESTERASE-RXN xref: UM-BBD_reactionID:r0757 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004065 name: arylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1] subset: gosubset_prok synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulphatase activity" EXACT [] synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004066 name: asparagine synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] subset: gosubset_prok synonym: "AS" RELATED [EC:6.3.5.4] synonym: "AS-B activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] xref: EC:6.3.5.4 xref: MetaCyc:ASNSYNB-RXN xref: Reactome:REACT_102336 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Schizosaccharomyces pombe" xref: Reactome:REACT_107530 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Escherichia coli" xref: Reactome:REACT_109835 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Mus musculus" xref: Reactome:REACT_112740 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Oryza sativa" xref: Reactome:REACT_113607 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Arabidopsis thaliana" xref: Reactome:REACT_114769 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Saccharomyces cerevisiae" xref: Reactome:REACT_277 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Homo sapiens" xref: Reactome:REACT_30477 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Rattus norvegicus" xref: Reactome:REACT_31824 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Mycobacterium tuberculosis" xref: Reactome:REACT_31879 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Drosophila melanogaster" xref: Reactome:REACT_34512 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Canis familiaris" xref: Reactome:REACT_80145 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Plasmodium falciparum" xref: Reactome:REACT_80719 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Xenopus tropicalis" xref: Reactome:REACT_81036 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Dictyostelium discoideum" xref: Reactome:REACT_86665 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Caenorhabditis elegans" xref: Reactome:REACT_86705 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Bos taurus" xref: Reactome:REACT_91813 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Sus scrofa" xref: Reactome:REACT_94577 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Taeniopygia guttata" xref: Reactome:REACT_95520 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Gallus gallus" xref: Reactome:REACT_97491 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Danio rerio" xref: RHEA:24877 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004067 name: asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] subset: gosubset_prok synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "asparaginase II" RELATED [EC:3.5.1.1] synonym: "colaspase activity" EXACT [EC:3.5.1.1] synonym: "crasnitin" RELATED [EC:3.5.1.1] synonym: "elspar" RELATED [EC:3.5.1.1] synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] synonym: "leunase activity" EXACT [EC:3.5.1.1] xref: EC:3.5.1.1 xref: MetaCyc:ASPARAGHYD-RXN xref: RHEA:21019 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004068 name: aspartate 1-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] subset: gosubset_prok synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] xref: EC:4.1.1.11 xref: MetaCyc:ASPDECARBOX-RXN xref: MetaCyc:PWY-5155 xref: RHEA:19500 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004069 name: L-aspartate:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] subset: gosubset_prok synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AAT" RELATED [EC:2.6.1.1] synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate aminotransferase activity" BROAD [] synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "AspT" RELATED [EC:2.6.1.1] synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "transaminase A activity" RELATED [EC:2.6.1.1] xref: EC:2.6.1.1 xref: MetaCyc:ASPAMINOTRANS-RXN xref: Reactome:REACT_100250 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Rattus norvegicus" xref: Reactome:REACT_100619 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Mus musculus" xref: Reactome:REACT_101098 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Gallus gallus" xref: Reactome:REACT_102229 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Bos taurus" xref: Reactome:REACT_102338 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Bos taurus" xref: Reactome:REACT_104061 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Canis familiaris" xref: Reactome:REACT_104242 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Sus scrofa" xref: Reactome:REACT_104365 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Dictyostelium discoideum" xref: Reactome:REACT_104429 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Drosophila melanogaster" xref: Reactome:REACT_105965 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Schizosaccharomyces pombe" xref: Reactome:REACT_106583 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Escherichia coli" xref: Reactome:REACT_107401 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Oryza sativa" xref: Reactome:REACT_107422 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Taeniopygia guttata" xref: Reactome:REACT_107443 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Canis familiaris" xref: Reactome:REACT_107885 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Oryza sativa" xref: Reactome:REACT_108823 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Mus musculus" xref: Reactome:REACT_109829 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Sus scrofa" xref: Reactome:REACT_110632 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Gallus gallus" xref: Reactome:REACT_110701 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Taeniopygia guttata" xref: Reactome:REACT_112410 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Plasmodium falciparum" xref: Reactome:REACT_112542 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Plasmodium falciparum" xref: Reactome:REACT_113079 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Plasmodium falciparum" xref: Reactome:REACT_115016 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Rattus norvegicus" xref: Reactome:REACT_115018 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Rattus norvegicus" xref: Reactome:REACT_115062 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Plasmodium falciparum" xref: Reactome:REACT_115765 "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate, Gallus gallus" xref: Reactome:REACT_115783 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate), Gallus gallus" xref: Reactome:REACT_115863 "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate, Gallus gallus" xref: Reactome:REACT_115958 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate), Gallus gallus" xref: Reactome:REACT_1558 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Homo sapiens" xref: Reactome:REACT_1632 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Homo sapiens" xref: Reactome:REACT_2078 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Homo sapiens" xref: Reactome:REACT_280 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Homo sapiens" xref: Reactome:REACT_28947 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Taeniopygia guttata" xref: Reactome:REACT_28965 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Sus scrofa" xref: Reactome:REACT_31038 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Caenorhabditis elegans" xref: Reactome:REACT_31146 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Canis familiaris" xref: Reactome:REACT_32675 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Drosophila melanogaster" xref: Reactome:REACT_34387 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Danio rerio" xref: Reactome:REACT_34754 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Dictyostelium discoideum" xref: Reactome:REACT_67549 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Schizosaccharomyces pombe" xref: Reactome:REACT_77562 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Dictyostelium discoideum" xref: Reactome:REACT_77740 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Arabidopsis thaliana" xref: Reactome:REACT_79228 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Drosophila melanogaster" xref: Reactome:REACT_80018 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Arabidopsis thaliana" xref: Reactome:REACT_80569 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Caenorhabditis elegans" xref: Reactome:REACT_80879 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Xenopus tropicalis" xref: Reactome:REACT_82087 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Gallus gallus" xref: Reactome:REACT_82808 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Escherichia coli" xref: Reactome:REACT_82944 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Danio rerio" xref: Reactome:REACT_83266 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Escherichia coli" xref: Reactome:REACT_84706 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Bos taurus" xref: Reactome:REACT_84867 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Canis familiaris" xref: Reactome:REACT_85085 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Bos taurus" xref: Reactome:REACT_86159 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Xenopus tropicalis" xref: Reactome:REACT_86367 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Taeniopygia guttata" xref: Reactome:REACT_87626 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Arabidopsis thaliana" xref: Reactome:REACT_89219 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Oryza sativa" xref: Reactome:REACT_89337 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Mus musculus" xref: Reactome:REACT_89398 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Arabidopsis thaliana" xref: Reactome:REACT_89436 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Drosophila melanogaster" xref: Reactome:REACT_90427 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Gallus gallus" xref: Reactome:REACT_91145 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Sus scrofa" xref: Reactome:REACT_91482 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Mus musculus" xref: Reactome:REACT_91798 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Xenopus tropicalis" xref: Reactome:REACT_92155 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Oryza sativa" xref: Reactome:REACT_92692 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Dictyostelium discoideum" xref: Reactome:REACT_93130 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Caenorhabditis elegans" xref: Reactome:REACT_93870 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Escherichia coli" xref: Reactome:REACT_94071 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Schizosaccharomyces pombe" xref: Reactome:REACT_94790 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Schizosaccharomyces pombe" xref: Reactome:REACT_95383 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Danio rerio" xref: Reactome:REACT_95640 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Caenorhabditis elegans" xref: Reactome:REACT_95714 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Xenopus tropicalis" xref: Reactome:REACT_96608 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Saccharomyces cerevisiae" xref: Reactome:REACT_98136 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Rattus norvegicus" xref: Reactome:REACT_98564 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Saccharomyces cerevisiae" xref: Reactome:REACT_99695 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Danio rerio" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004070 name: aspartate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016] subset: gosubset_prok synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "ATCase activity" EXACT [EC:2.1.3.2] synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] xref: EC:2.1.3.2 xref: KEGG:R01397 xref: MetaCyc:ASPCARBTRANS-RXN xref: Reactome:REACT_103105 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_105018 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Taeniopygia guttata" xref: Reactome:REACT_107363 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Staphylococcus aureus N315" xref: Reactome:REACT_110200 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Plasmodium falciparum" xref: Reactome:REACT_115976 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Gallus gallus" xref: Reactome:REACT_1965 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Homo sapiens" xref: Reactome:REACT_30409 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Bos taurus" xref: Reactome:REACT_30529 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Canis familiaris" xref: Reactome:REACT_80965 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Rattus norvegicus" xref: Reactome:REACT_89217 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Danio rerio" xref: Reactome:REACT_90716 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Mus musculus" xref: Reactome:REACT_91724 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Caenorhabditis elegans" xref: Reactome:REACT_96047 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Dictyostelium discoideum" xref: Reactome:REACT_98356 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Drosophila melanogaster" xref: Reactome:REACT_98452 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Saccharomyces cerevisiae" xref: RHEA:20016 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004071 name: aspartate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] subset: gosubset_prok synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] xref: EC:6.3.1.1 xref: MetaCyc:ASNSYNA-RXN xref: RHEA:11375 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004072 name: aspartate kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23779] subset: gosubset_prok synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] xref: EC:2.7.2.4 xref: KEGG:R00480 xref: MetaCyc:ASPARTATEKIN-RXN xref: RHEA:23779 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004073 name: aspartate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24287] subset: gosubset_prok synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] xref: EC:1.2.1.11 xref: KEGG:R02291 xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:24287 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004074 name: biliverdin reductase activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN xref: Reactome:REACT_22177 "Biliverdin is reduced to bilirubin, Homo sapiens" xref: Reactome:REACT_31500 "Biliverdin is reduced to bilirubin, Mus musculus" xref: Reactome:REACT_32959 "Biliverdin is reduced to bilirubin, Danio rerio" xref: Reactome:REACT_34270 "Biliverdin is reduced to bilirubin, Gallus gallus" xref: Reactome:REACT_81350 "Biliverdin is reduced to bilirubin, Drosophila melanogaster" xref: Reactome:REACT_82319 "Biliverdin is reduced to bilirubin, Bos taurus" xref: Reactome:REACT_88875 "Biliverdin is reduced to bilirubin, Taeniopygia guttata" xref: Reactome:REACT_89833 "Biliverdin is reduced to bilirubin, Rattus norvegicus" xref: Reactome:REACT_91067 "Biliverdin is reduced to bilirubin, Xenopus tropicalis" xref: Reactome:REACT_91178 "Biliverdin is reduced to bilirubin, Sus scrofa" xref: Reactome:REACT_93458 "Biliverdin is reduced to bilirubin, Canis familiaris" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004075 name: biotin carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] subset: gosubset_prok synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: MetaCyc:BIOTIN-CARBOXYL-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004076 name: biotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22063] subset: gosubset_prok synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] xref: EC:2.8.1.6 xref: KEGG:R01078 xref: MetaCyc:2.8.1.6-RXN xref: RHEA:22063 is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0004077 name: biotin-[acetyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] subset: gosubset_prok synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: MetaCyc:BIOTINLIG-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004078 name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: MetaCyc:6.3.4.11-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004079 name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: MetaCyc:6.3.4.9-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004080 name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: MetaCyc:6.3.4.10-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004081 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: MetaCyc:3.6.1.17-RXN xref: RHEA:22487 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0004082 name: bisphosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] synonym: "BPGM activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "DPGM" RELATED [EC:5.4.2.4] synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] xref: EC:5.4.2.4 xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN xref: RHEA:17768 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004083 name: bisphosphoglycerate 2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [EC:3.1.3.13, RHEA:21907] synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" BROAD [EC:3.1.3.13] xref: EC:3.1.3.13 xref: KEGG:R01516 xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:21907 is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0004084 name: branched-chain-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah] subset: gosubset_prok synonym: "branched-chain amino acid aminotransferase activity" EXACT [] synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "transaminase B activity" RELATED [EC:2.6.1.42] xref: EC:2.6.1.42 xref: Reactome:REACT_103033 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Schizosaccharomyces pombe" xref: Reactome:REACT_104255 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Bos taurus" xref: Reactome:REACT_109061 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Rattus norvegicus" xref: Reactome:REACT_112447 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Xenopus tropicalis" xref: Reactome:REACT_1136 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Homo sapiens" xref: Reactome:REACT_2034 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Homo sapiens" xref: Reactome:REACT_21283 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1], Homo sapiens" xref: Reactome:REACT_21409 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2], Homo sapiens" xref: Reactome:REACT_29623 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Drosophila melanogaster" xref: Reactome:REACT_31174 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Dictyostelium discoideum" xref: Reactome:REACT_31737 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Gallus gallus" xref: Reactome:REACT_31924 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Staphylococcus aureus N315" xref: Reactome:REACT_32127 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Canis familiaris" xref: Reactome:REACT_76927 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Mus musculus" xref: Reactome:REACT_81549 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Schizosaccharomyces pombe" xref: Reactome:REACT_84147 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Dictyostelium discoideum" xref: Reactome:REACT_85686 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Mycobacterium tuberculosis" xref: Reactome:REACT_87300 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Canis familiaris" xref: Reactome:REACT_87826 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Caenorhabditis elegans" xref: Reactome:REACT_89738 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Drosophila melanogaster" xref: Reactome:REACT_93129 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Saccharomyces cerevisiae" xref: Reactome:REACT_95349 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Rattus norvegicus" xref: Reactome:REACT_95545 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Mus musculus" xref: Reactome:REACT_96261 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Sus scrofa" xref: Reactome:REACT_96398 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Danio rerio" xref: Reactome:REACT_97251 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Xenopus tropicalis" xref: Reactome:REACT_97510 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Caenorhabditis elegans" xref: Reactome:REACT_97898 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Saccharomyces cerevisiae" xref: Reactome:REACT_99130 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Taeniopygia guttata" xref: Reactome:REACT_99998 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Bos taurus" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004085 name: butyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein." [EC:1.3.8.1] subset: gosubset_prok synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.8.1] synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1] synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1] synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.8.1] synonym: "ethylene reductase activity" EXACT [EC:1.3.8.1] synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.1] synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.8.1] synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.8.1] xref: EC:1.3.8.1 xref: KEGG:R01178 xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0013 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0004086 name: carbamoyl-phosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] comment: This term was made obsolete because it is a grouping term based on name, rather than on function. synonym: "carbamoyl phosphate synthase activity" EXACT [] is_obsolete: true consider: GO:0004087 consider: GO:0004088 [Term] id: GO:0004087 name: carbamoyl-phosphate synthase (ammonia) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10627] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] synonym: "CPS I activity" NARROW [EC:6.3.4.16] xref: EC:6.3.4.16 xref: KEGG:R00149 xref: MetaCyc:6.3.4.16-RXN xref: Reactome:REACT_104425 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Bos taurus" xref: Reactome:REACT_112052 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Plasmodium falciparum" xref: Reactome:REACT_112191 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Saccharomyces cerevisiae" xref: Reactome:REACT_112781 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Schizosaccharomyces pombe" xref: Reactome:REACT_1701 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Homo sapiens" xref: Reactome:REACT_28657 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Gallus gallus" xref: Reactome:REACT_32408 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Staphylococcus aureus N315" xref: Reactome:REACT_32830 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Taeniopygia guttata" xref: Reactome:REACT_45108 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Mus musculus" xref: Reactome:REACT_78285 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Xenopus tropicalis" xref: Reactome:REACT_79612 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Danio rerio" xref: Reactome:REACT_81920 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Sus scrofa" xref: Reactome:REACT_87223 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Canis familiaris" xref: Reactome:REACT_89630 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Rattus norvegicus" xref: RHEA:10627 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004088 name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] synonym: "CPS activity" EXACT [EC:6.3.5.5] synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] xref: EC:6.3.5.5 xref: MetaCyc:CARBPSYN-RXN xref: Reactome:REACT_102934 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_115736 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Gallus gallus" xref: Reactome:REACT_28976 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Staphylococcus aureus N315" xref: Reactome:REACT_29452 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Taeniopygia guttata" xref: Reactome:REACT_30926 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_478 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Homo sapiens" xref: Reactome:REACT_77966 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Bos taurus" xref: Reactome:REACT_79566 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Canis familiaris" xref: Reactome:REACT_83511 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Mus musculus" xref: Reactome:REACT_86599 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Caenorhabditis elegans" xref: Reactome:REACT_86815 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Plasmodium falciparum" xref: Reactome:REACT_88920 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Danio rerio" xref: Reactome:REACT_89432 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Dictyostelium discoideum" xref: Reactome:REACT_94822 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Drosophila melanogaster" xref: Reactome:REACT_96943 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Rattus norvegicus" xref: RHEA:24654 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004089 name: carbonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] subset: gosubset_prok synonym: "anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] synonym: "carbonic anhydrase activity" EXACT [] synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] xref: EC:4.2.1.1 xref: MetaCyc:CARBODEHYDRAT-RXN xref: RHEA:10751 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004090 name: carbonyl reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] subset: gosubset_prok synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] synonym: "ALR3" RELATED [EC:1.1.1.184] synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] xref: EC:1.1.1.184 xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN xref: RHEA:19260 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004091 name: carboxylesterase activity namespace: molecular_function alt_id: GO:0004302 alt_id: GO:0004759 alt_id: GO:0016789 def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1] subset: gosubset_prok synonym: "Ali-esterase activity" RELATED [EC:3.1.1.1] synonym: "ali-esterase activity" EXACT [EC:3.1.1.1] synonym: "alpha-carboxylesterase activity" EXACT [EC:3.1.1.1] synonym: "B-esterase activity" RELATED [EC:3.1.1.1] synonym: "carboxyesterase activity" EXACT [EC:3.1.1.1] synonym: "carboxyl ester hydrolase activity" RELATED [EC:3.1.1.1] synonym: "carboxylate esterase activity" EXACT [EC:3.1.1.1] synonym: "carboxylic acid esterase activity" EXACT [] synonym: "carboxylic ester hydrolase activity" RELATED [] synonym: "carboxylic esterase activity" EXACT [EC:3.1.1.1] synonym: "cocaine esterase activity" NARROW [EC:3.1.1.1] synonym: "esterase A" RELATED [EC:3.1.1.1] synonym: "esterase B" RELATED [EC:3.1.1.1] synonym: "nonspecific carboxylesterase activity" EXACT [EC:3.1.1.1] synonym: "procaine esterase activity" NARROW [EC:3.1.1.1] synonym: "serine esterase activity" EXACT [] synonym: "triacetin esterase" NARROW [EC:3.1.1.1] synonym: "vitamin A esterase" NARROW [EC:3.1.1.1] xref: EC:3.1.1.1 xref: KEGG:R00630 xref: MetaCyc:CARBOXYLESTERASE-RXN xref: UM-BBD_reactionID:r1025 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004092 name: carnitine O-acetyltransferase activity namespace: molecular_function alt_id: GO:0004093 alt_id: GO:0004094 def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21139] subset: gosubset_prok synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine O-acetyltransferase I activity" NARROW [] synonym: "carnitine O-acetyltransferase II activity" NARROW [] synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] synonym: "CATC" RELATED [EC:2.3.1.7] xref: EC:2.3.1.7 xref: KEGG:R02396 xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:REACT_106381 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Gallus gallus" xref: Reactome:REACT_107669 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Rattus norvegicus" xref: Reactome:REACT_16949 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Homo sapiens" xref: Reactome:REACT_16977 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Homo sapiens" xref: Reactome:REACT_32144 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Xenopus tropicalis" xref: Reactome:REACT_34276 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Bos taurus" xref: Reactome:REACT_34588 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Sus scrofa" xref: Reactome:REACT_34633 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Taeniopygia guttata" xref: Reactome:REACT_34692 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Sus scrofa" xref: Reactome:REACT_77010 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Danio rerio" xref: Reactome:REACT_77298 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Mus musculus" xref: Reactome:REACT_78054 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Rattus norvegicus" xref: Reactome:REACT_79550 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Taeniopygia guttata" xref: Reactome:REACT_85497 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Gallus gallus" xref: Reactome:REACT_87499 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Xenopus tropicalis" xref: Reactome:REACT_87701 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Canis familiaris" xref: Reactome:REACT_90661 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Mus musculus" xref: Reactome:REACT_92700 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Danio rerio" xref: Reactome:REACT_94633 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Bos taurus" xref: Reactome:REACT_98210 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Canis familiaris" xref: RHEA:21139 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004095 name: carnitine O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] synonym: "CPT" RELATED [EC:2.3.1.21] synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] synonym: "CPT-A" RELATED [EC:2.3.1.21] synonym: "CPT-B" RELATED [EC:2.3.1.21] synonym: "CPTi" RELATED [EC:2.3.1.21] synonym: "CPTo" RELATED [EC:2.3.1.21] synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] xref: EC:2.3.1.21 xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN xref: Reactome:REACT_106987 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Drosophila melanogaster" xref: Reactome:REACT_108163 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Caenorhabditis elegans" xref: Reactome:REACT_11133 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Homo sapiens" xref: Reactome:REACT_11185 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Homo sapiens" xref: Reactome:REACT_30467 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Danio rerio" xref: Reactome:REACT_33707 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Mus musculus" xref: Reactome:REACT_34534 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Taeniopygia guttata" xref: Reactome:REACT_77063 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Danio rerio" xref: Reactome:REACT_78400 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Gallus gallus" xref: Reactome:REACT_78721 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Xenopus tropicalis" xref: Reactome:REACT_83067 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Canis familiaris" xref: Reactome:REACT_83898 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Rattus norvegicus" xref: Reactome:REACT_86504 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Xenopus tropicalis" xref: Reactome:REACT_86687 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Rattus norvegicus" xref: Reactome:REACT_87240 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Gallus gallus" xref: Reactome:REACT_88030 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Bos taurus" xref: Reactome:REACT_88075 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Mus musculus" xref: Reactome:REACT_89612 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Bos taurus" xref: Reactome:REACT_92120 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Caenorhabditis elegans" xref: Reactome:REACT_94774 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Drosophila melanogaster" xref: Reactome:REACT_95110 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Canis familiaris" xref: Reactome:REACT_95133 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Sus scrofa" xref: Reactome:REACT_95851 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Sus scrofa" xref: Reactome:REACT_99269 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Taeniopygia guttata" xref: RHEA:12664 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0004096 name: catalase activity namespace: molecular_function alt_id: GO:0016952 alt_id: GO:0016953 def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: MetaCyc:CATAL-RXN xref: Reactome:REACT_101648 "2 H2O2 => O2 + 2 H2O, Gallus gallus" xref: Reactome:REACT_108235 "2 H2O2 => O2 + 2 H2O, Saccharomyces cerevisiae" xref: Reactome:REACT_112160 "2 H2O2 => O2 + 2 H2O, Caenorhabditis elegans" xref: Reactome:REACT_30681 "2 H2O2 => O2 + 2 H2O, Escherichia coli" xref: Reactome:REACT_30704 "2 H2O2 => O2 + 2 H2O, Drosophila melanogaster" xref: Reactome:REACT_30957 "2 H2O2 => O2 + 2 H2O, Mus musculus" xref: Reactome:REACT_615 "2 H2O2 => O2 + 2 H2O, Homo sapiens" xref: Reactome:REACT_79013 "2 H2O2 => O2 + 2 H2O, Taeniopygia guttata" xref: Reactome:REACT_79757 "2 H2O2 => O2 + 2 H2O, Schizosaccharomyces pombe" xref: Reactome:REACT_85074 "2 H2O2 => O2 + 2 H2O, Staphylococcus aureus N315" xref: Reactome:REACT_85170 "2 H2O2 => O2 + 2 H2O, Bos taurus" xref: Reactome:REACT_87638 "2 H2O2 => O2 + 2 H2O, Dictyostelium discoideum" xref: Reactome:REACT_89864 "2 H2O2 => O2 + 2 H2O, Sus scrofa" xref: Reactome:REACT_90743 "2 H2O2 => O2 + 2 H2O, Rattus norvegicus" xref: Reactome:REACT_91037 "2 H2O2 => O2 + 2 H2O, Danio rerio" xref: Reactome:REACT_91307 "2 H2O2 => O2 + 2 H2O, Canis familiaris" xref: Reactome:REACT_96832 "2 H2O2 => O2 + 2 H2O, Xenopus tropicalis" xref: RHEA:20312 xref: UM-BBD_enzymeID:e0834 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004097 name: catechol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'. subset: gosubset_prok synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] synonym: "catecholase" BROAD [EC:1.10.3.1] synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "dopa oxidase" BROAD [EC:1.10.3.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] synonym: "phenolase activity" BROAD [EC:1.10.3.1] synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] xref: EC:1.10.3.1 xref: MetaCyc:CATECHOL-OXIDASE-RXN xref: RHEA:21635 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0004098 name: cerebroside-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8] subset: gosubset_prok synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN xref: Reactome:REACT_115556 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside, Homo sapiens" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004099 name: chitin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] subset: gosubset_prok synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] xref: EC:3.5.1.41 xref: MetaCyc:CHITIN-DEACETYLASE-RXN xref: RHEA:10467 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0004100 name: chitin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16] subset: gosubset_prok synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: MetaCyc:CHITIN-SYNTHASE-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004102 name: choline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18824] subset: gosubset_prok synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] xref: EC:2.3.1.6 xref: KEGG:R01023 xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:REACT_105936 "Cho is acetylated to AcCho by CHAT, Gallus gallus" xref: Reactome:REACT_108136 "Cho is acetylated to AcCho by CHAT, Taeniopygia guttata" xref: Reactome:REACT_109278 "Cho is acetylated to AcCho by CHAT, Bos taurus" xref: Reactome:REACT_15484 "Cho is acetylated to AcCho by CHAT, Homo sapiens" xref: Reactome:REACT_29952 "Cho is acetylated to AcCho by CHAT, Canis familiaris" xref: Reactome:REACT_31186 "Cho is acetylated to AcCho by CHAT, Drosophila melanogaster" xref: Reactome:REACT_77093 "Cho is acetylated to AcCho by CHAT, Danio rerio" xref: Reactome:REACT_87316 "Cho is acetylated to AcCho by CHAT, Caenorhabditis elegans" xref: Reactome:REACT_94484 "Cho is acetylated to AcCho by CHAT, Rattus norvegicus" xref: Reactome:REACT_96109 "Cho is acetylated to AcCho by CHAT, Sus scrofa" xref: Reactome:REACT_97062 "Cho is acetylated to AcCho by CHAT, Mus musculus" xref: Reactome:REACT_98162 "Cho is acetylated to AcCho by CHAT, Xenopus tropicalis" xref: RHEA:18824 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004103 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12840] subset: gosubset_prok synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] xref: EC:2.7.1.32 xref: KEGG:R01021 xref: MetaCyc:CHOLINE-KINASE-RXN xref: RHEA:12840 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: gosubset_prok synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: RHEA:21967 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004105 name: choline-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] subset: gosubset_prok synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] xref: EC:2.7.7.15 xref: MetaCyc:2.7.7.15-RXN xref: RHEA:19000 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004106 name: chorismate mutase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13900] subset: gosubset_prok synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] xref: EC:5.4.99.5 xref: KEGG:R01715 xref: MetaCyc:CHORISMATEMUT-RXN xref: RHEA:13900 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004107 name: chorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21023] subset: gosubset_prok synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] xref: EC:4.2.3.5 xref: KEGG:R01714 xref: MetaCyc:CHORISMATE-SYNTHASE-RXN xref: Reactome:REACT_27204 "Dephosphorylation of EPSP yields chorismate, Mycobacterium tuberculosis" xref: RHEA:21023 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004108 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] comment: Note that this function was formerly EC:4.1.3.7. subset: gosubset_prok synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: MetaCyc:CITSYN-RXN xref: Reactome:REACT_100557 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Mus musculus" xref: Reactome:REACT_100736 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Staphylococcus aureus N315" xref: Reactome:REACT_103631 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Xenopus tropicalis" xref: Reactome:REACT_107569 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Rattus norvegicus" xref: Reactome:REACT_108814 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Bos taurus" xref: Reactome:REACT_115605 "acetyl-CoA + H2O + oxaloacetate => citrate + CoA, Gallus gallus" xref: Reactome:REACT_1282 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Homo sapiens" xref: Reactome:REACT_32191 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Drosophila melanogaster" xref: Reactome:REACT_33399 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Danio rerio" xref: Reactome:REACT_81174 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Dictyostelium discoideum" xref: Reactome:REACT_81802 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Plasmodium falciparum" xref: Reactome:REACT_83386 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Oryza sativa" xref: Reactome:REACT_87177 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Arabidopsis thaliana" xref: Reactome:REACT_88391 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Caenorhabditis elegans" xref: Reactome:REACT_91540 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Canis familiaris" xref: Reactome:REACT_94285 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_96879 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Sus scrofa" xref: RHEA:16848 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004109 name: coproporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260] subset: gosubset_prok synonym: "coprogen oxidase activity" EXACT [] synonym: "coproporphyrinogen-III oxidase activity" EXACT [] synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] synonym: "coproporphyrinogenase activity" EXACT [] xref: EC:1.3.3.3 xref: KEGG:R03220 xref: MetaCyc:RXN0-1461 xref: Reactome:REACT_100303 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Dictyostelium discoideum" xref: Reactome:REACT_102127 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Plasmodium falciparum" xref: Reactome:REACT_106413 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Saccharomyces cerevisiae" xref: Reactome:REACT_109036 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Sus scrofa" xref: Reactome:REACT_109488 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Drosophila melanogaster" xref: Reactome:REACT_116046 "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2, Gallus gallus" xref: Reactome:REACT_28640 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Mus musculus" xref: Reactome:REACT_31610 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Danio rerio" xref: Reactome:REACT_33035 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Taeniopygia guttata" xref: Reactome:REACT_33168 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Xenopus tropicalis" xref: Reactome:REACT_79367 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Escherichia coli" xref: Reactome:REACT_82126 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Oryza sativa" xref: Reactome:REACT_83357 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Arabidopsis thaliana" xref: Reactome:REACT_90082 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Canis familiaris" xref: Reactome:REACT_90208 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Gallus gallus" xref: Reactome:REACT_91427 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Rattus norvegicus" xref: Reactome:REACT_93659 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Schizosaccharomyces pombe" xref: Reactome:REACT_9421 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Homo sapiens" xref: Reactome:REACT_98194 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Bos taurus" xref: RHEA:18260 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004110 name: corticosteroid side-chain-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17864] synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] xref: EC:5.3.1.21 xref: KEGG:R04165 xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN xref: RHEA:17864 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004111 name: creatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17160] synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "BB-CK" RELATED [EC:2.7.3.2] synonym: "CK" RELATED [EC:2.7.3.2] synonym: "CK-BB" RELATED [EC:2.7.3.2] synonym: "CK-MB" RELATED [EC:2.7.3.2] synonym: "CK-MM" RELATED [EC:2.7.3.2] synonym: "CKMiMi" RELATED [EC:2.7.3.2] synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "MB-CK" RELATED [EC:2.7.3.2] synonym: "Mi-CK" RELATED [EC:2.7.3.2] synonym: "MiMi-CK" RELATED [EC:2.7.3.2] synonym: "MM-CK" RELATED [EC:2.7.3.2] synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] xref: EC:2.7.3.2 xref: KEGG:R01881 xref: MetaCyc:CREATINE-KINASE-RXN xref: Reactome:REACT_100539 "creatine + ATP => phosphocreatine + ADP [CK octamer], Gallus gallus" xref: Reactome:REACT_101438 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Rattus norvegicus" xref: Reactome:REACT_105411 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Xenopus tropicalis" xref: Reactome:REACT_108499 "creatine + ATP => phosphocreatine + ADP [CK octamer], Xenopus tropicalis" xref: Reactome:REACT_109981 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Bos taurus" xref: Reactome:REACT_110682 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Gallus gallus" xref: Reactome:REACT_11155 "creatine + ATP => phosphocreatine + ADP [CK octamer], Homo sapiens" xref: Reactome:REACT_11156 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Homo sapiens" xref: Reactome:REACT_111938 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Staphylococcus aureus N315" xref: Reactome:REACT_112531 "creatine + ATP => phosphocreatine + ADP [CK octamer], Staphylococcus aureus N315" xref: Reactome:REACT_113875 "creatine + ATP => phosphocreatine + ADP [CK octamer], Rattus norvegicus" xref: Reactome:REACT_31867 "creatine + ATP => phosphocreatine + ADP [CK octamer], Canis familiaris" xref: Reactome:REACT_32596 "creatine + ATP => phosphocreatine + ADP [CK octamer], Bos taurus" xref: Reactome:REACT_34284 "creatine + ATP => phosphocreatine + ADP [CK octamer], Sus scrofa" xref: Reactome:REACT_84876 "creatine + ATP => phosphocreatine + ADP [CK octamer], Taeniopygia guttata" xref: Reactome:REACT_87789 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Taeniopygia guttata" xref: Reactome:REACT_90123 "creatine + ATP => phosphocreatine + ADP [CK octamer], Mus musculus" xref: Reactome:REACT_94681 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Canis familiaris" xref: Reactome:REACT_94782 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Danio rerio" xref: Reactome:REACT_96287 "creatine + ATP => phosphocreatine + ADP [CK octamer], Danio rerio" xref: Reactome:REACT_99155 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Mus musculus" xref: RHEA:17160 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004112 name: cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.4.- is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004113 name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] subset: gosubset_prok synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "CNPase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: MetaCyc:3.1.4.37-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004114 name: 3',5'-cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] subset: gosubset_prok synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "PDE" RELATED [EC:3.1.4.17] xref: EC:3.1.4.17 xref: MetaCyc:3.1.4.17-RXN xref: Reactome:REACT_105099 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Taeniopygia guttata" xref: Reactome:REACT_106371 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Canis familiaris" xref: Reactome:REACT_109851 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Caenorhabditis elegans" xref: Reactome:REACT_114232 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Plasmodium falciparum" xref: Reactome:REACT_28964 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Mus musculus" xref: Reactome:REACT_325 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Homo sapiens" xref: Reactome:REACT_80740 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Rattus norvegicus" xref: Reactome:REACT_82008 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Sus scrofa" xref: Reactome:REACT_83917 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Bos taurus" xref: Reactome:REACT_91190 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Gallus gallus" xref: Reactome:REACT_98934 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Xenopus tropicalis" xref: Reactome:REACT_99156 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Danio rerio" xref: RHEA:14656 is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004115 name: 3',5'-cyclic-AMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4.- xref: MetaCyc:RXN0-5038 xref: Reactome:REACT_103170 "cAMP hydrolysis by PDE 4, Sus scrofa" xref: Reactome:REACT_104009 "cAMP degradation by Phosphodiesterases, Mus musculus" xref: Reactome:REACT_109814 "cAMP degradation by Phosphodiesterases, Sus scrofa" xref: Reactome:REACT_110463 "cAMP hydrolysis by PDE 4, Gallus gallus" xref: Reactome:REACT_112238 "cAMP hydrolysis by PDE 4, Dictyostelium discoideum" xref: Reactome:REACT_115186 "cAMP hydrolysis by PDE 4, Plasmodium falciparum" xref: Reactome:REACT_1257 "cAMP hydrolysis by PDE 4, Homo sapiens" xref: Reactome:REACT_19387 "cAMP degradation by Phosphodiesterases, Homo sapiens" xref: Reactome:REACT_30870 "cAMP hydrolysis by PDE 4, Xenopus tropicalis" xref: Reactome:REACT_31083 "cAMP hydrolysis by PDE 4, Taeniopygia guttata" xref: Reactome:REACT_31890 "cAMP degradation by Phosphodiesterases, Gallus gallus" xref: Reactome:REACT_33515 "cAMP hydrolysis by PDE 4, Caenorhabditis elegans" xref: Reactome:REACT_33747 "cAMP degradation by Phosphodiesterases, Drosophila melanogaster" xref: Reactome:REACT_34147 "cAMP degradation by Phosphodiesterases, Rattus norvegicus" xref: Reactome:REACT_34190 "cAMP hydrolysis by PDE 4, Mus musculus" xref: Reactome:REACT_77308 "cAMP degradation by Phosphodiesterases, Plasmodium falciparum" xref: Reactome:REACT_82598 "cAMP degradation by Phosphodiesterases, Caenorhabditis elegans" xref: Reactome:REACT_85939 "cAMP hydrolysis by PDE 4, Rattus norvegicus" xref: Reactome:REACT_86709 "cAMP hydrolysis by PDE 4, Bos taurus" xref: Reactome:REACT_88948 "cAMP hydrolysis by PDE 4, Danio rerio" xref: Reactome:REACT_89237 "cAMP hydrolysis by PDE 4, Drosophila melanogaster" xref: Reactome:REACT_94229 "cAMP degradation by Phosphodiesterases, Dictyostelium discoideum" xref: Reactome:REACT_96329 "cAMP degradation by Phosphodiesterases, Bos taurus" xref: Reactome:REACT_96372 "cAMP degradation by Phosphodiesterases, Canis familiaris" xref: Reactome:REACT_98400 "cAMP degradation by Phosphodiesterases, Danio rerio" xref: Reactome:REACT_99458 "cAMP degradation by Phosphodiesterases, Xenopus tropicalis" xref: Reactome:REACT_99647 "cAMP hydrolysis by PDE 4, Canis familiaris" xref: Reactome:REACT_99851 "cAMP degradation by Phosphodiesterases, Taeniopygia guttata" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004117 name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] xref: EC:3.1.4.- xref: Reactome:REACT_100660 "cAMP hydrolysis by Cam-PDE 1, Xenopus tropicalis" xref: Reactome:REACT_102161 "cAMP hydrolysis by Cam-PDE 1, Taeniopygia guttata" xref: Reactome:REACT_104978 "cAMP hydrolysis by Cam-PDE 1, Bos taurus" xref: Reactome:REACT_105407 "cAMP hydrolysis by Cam-PDE 1, Rattus norvegicus" xref: Reactome:REACT_105998 "cAMP hydrolysis by Cam-PDE 1, Canis familiaris" xref: Reactome:REACT_114149 "cAMP hydrolysis by Cam-PDE 1, Dictyostelium discoideum" xref: Reactome:REACT_114485 "cAMP hydrolysis by Cam-PDE 1, Plasmodium falciparum" xref: Reactome:REACT_28755 "cAMP hydrolysis by Cam-PDE 1, Drosophila melanogaster" xref: Reactome:REACT_33765 "cAMP hydrolysis by Cam-PDE 1, Danio rerio" xref: Reactome:REACT_82138 "cAMP hydrolysis by Cam-PDE 1, Sus scrofa" xref: Reactome:REACT_827 "cAMP hydrolysis by Cam-PDE 1, Homo sapiens" xref: Reactome:REACT_83188 "cAMP hydrolysis by Cam-PDE 1, Mus musculus" xref: Reactome:REACT_83224 "cAMP hydrolysis by Cam-PDE 1, Caenorhabditis elegans" xref: Reactome:REACT_85278 "cAMP hydrolysis by Cam-PDE 1, Gallus gallus" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004118 name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004119 name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004120 name: photoreceptor cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004121 name: cystathionine beta-lyase activity namespace: molecular_function alt_id: GO:0008799 def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] subset: gosubset_prok synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] xref: EC:4.4.1.8 xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN xref: RHEA:13968 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004122 name: cystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] subset: gosubset_prok synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN xref: Reactome:REACT_115874 "Cystathionine is formed from homocysteine and serine, Homo sapiens" xref: RHEA:10115 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004123 name: cystathionine gamma-lyase activity namespace: molecular_function alt_id: GO:0016225 def: "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:24918] synonym: "gamma-cystathionase activity" BROAD [EC:4.4.1.1] synonym: "homoserine deaminase activity" RELATED [EC:4.4.1.1] synonym: "homoserine deaminase-cystathionase activity" RELATED [EC:4.4.1.1] synonym: "homoserine dehydratase activity" RELATED [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating)" BROAD [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] xref: EC:4.4.1.1 xref: KEGG:R01001 xref: MetaCyc:CYSTAGLY-RXN xref: Reactome:REACT_116098 "Cleavage of cystathionine into cysteine, Homo sapiens" xref: Reactome:REACT_27170 "Cysteine from cystathionine and vice versa, Mycobacterium tuberculosis" xref: RHEA:24918 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004124 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:4.2.99.8] comment: Note that this function was formerly 4.2.99.8. subset: gosubset_prok synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: MetaCyc:ACSERLY-RXN xref: Reactome:REACT_27172 "deacetylation of O-acetylserine and sulfhydrylation using CysK2, Mycobacterium tuberculosis" xref: Reactome:REACT_27282 "deacetylation of O-acetylserine and sulfhydrylation using CysK1, Mycobacterium tuberculosis" xref: RHEA:14832 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0004125 name: L-seryl-tRNASec selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] subset: gosubset_prok synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "selenocysteine synthase activity" EXACT [] synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: MetaCyc:2.9.1.1-RXN is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups [Term] id: GO:0004126 name: cytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] subset: gosubset_prok synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] xref: EC:3.5.4.5 xref: MetaCyc:CYTIDEAM2-RXN xref: Reactome:REACT_100555 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Schizosaccharomyces pombe" xref: Reactome:REACT_102821 "C4 deamination of cytidine, Taeniopygia guttata" xref: Reactome:REACT_103670 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Drosophila melanogaster" xref: Reactome:REACT_104831 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Saccharomyces cerevisiae" xref: Reactome:REACT_105043 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Mus musculus" xref: Reactome:REACT_106971 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Gallus gallus" xref: Reactome:REACT_107871 "C4 deamination of cytidine, Mus musculus" xref: Reactome:REACT_108941 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Rattus norvegicus" xref: Reactome:REACT_30951 "C4 deamination of cytidine, Canis familiaris" xref: Reactome:REACT_376 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Homo sapiens" xref: Reactome:REACT_80189 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Bos taurus" xref: Reactome:REACT_81775 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Dictyostelium discoideum" xref: Reactome:REACT_86483 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Mycobacterium tuberculosis" xref: Reactome:REACT_86734 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Sus scrofa" xref: Reactome:REACT_869 "C4 deamination of cytidine, Homo sapiens" xref: Reactome:REACT_89154 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Taeniopygia guttata" xref: Reactome:REACT_91892 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Caenorhabditis elegans" xref: Reactome:REACT_92525 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Canis familiaris" xref: Reactome:REACT_92541 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Staphylococcus aureus N315" xref: Reactome:REACT_92713 "C4 deamination of cytidine, Rattus norvegicus" xref: Reactome:REACT_94503 "C4 deamination of cytidine, Bos taurus" xref: Reactome:REACT_94636 "C4 deamination of cytidine, Sus scrofa" xref: Reactome:REACT_94708 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Danio rerio" xref: RHEA:16072 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004127 name: cytidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] subset: gosubset_prok synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] xref: EC:2.7.4.14 xref: MetaCyc:CMPKI-RXN xref: RHEA:11604 xref: RHEA:25097 is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004128 name: cytochrome-b5 reductase activity, acting on NAD(P)H namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] xref: EC:1.6.2.2 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN xref: Reactome:REACT_103424 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Gallus gallus" xref: Reactome:REACT_104486 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Danio rerio" xref: Reactome:REACT_11182 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Homo sapiens" xref: Reactome:REACT_30308 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Mus musculus" xref: Reactome:REACT_78517 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Sus scrofa" xref: Reactome:REACT_79858 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Xenopus tropicalis" xref: Reactome:REACT_85388 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Rattus norvegicus" xref: Reactome:REACT_90736 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Bos taurus" xref: Reactome:REACT_90791 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Canis familiaris" xref: Reactome:REACT_95419 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Taeniopygia guttata" is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0004129 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. subset: gosubset_prok synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome c oxidase activity" EXACT [GOC:tb] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:REACT_113276 "Electron transfer from reduced cytochrome c to molecular oxygen, Bos taurus" xref: Reactome:REACT_113311 "Electron transfer from reduced cytochrome c to molecular oxygen, Sus scrofa" xref: Reactome:REACT_113736 "Electron transfer from reduced cytochrome c to molecular oxygen, Canis familiaris" xref: Reactome:REACT_115027 "Electron transfer from reduced cytochrome c to molecular oxygen, Rattus norvegicus" xref: Reactome:REACT_33608 "Electron transfer from reduced cytochrome c to molecular oxygen, Danio rerio" xref: Reactome:REACT_6149 "Electron transfer from reduced cytochrome c to molecular oxygen, Homo sapiens" xref: Reactome:REACT_78871 "Electron transfer from reduced cytochrome c to molecular oxygen, Gallus gallus" xref: Reactome:REACT_99789 "Electron transfer from reduced cytochrome c to molecular oxygen, Mus musculus" is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor [Term] id: GO:0004130 name: cytochrome-c peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] subset: gosubset_prok synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004131 name: cytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] subset: gosubset_prok synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] xref: EC:3.5.4.1 xref: MetaCyc:CYTDEAM-RXN xref: RHEA:20608 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004132 name: dCMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] subset: gosubset_prok synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] xref: EC:3.5.4.12 xref: MetaCyc:DCMP-DEAMINASE-RXN xref: Reactome:REACT_101387 "dCMP + H2O => dUMP + NH4+, Canis familiaris" xref: Reactome:REACT_102792 "dCMP + H2O => dUMP + NH4+, Arabidopsis thaliana" xref: Reactome:REACT_105322 "dCMP + H2O => dUMP + NH4+, Danio rerio" xref: Reactome:REACT_105695 "dCMP + H2O => dUMP + NH4+, Staphylococcus aureus N315" xref: Reactome:REACT_106595 "dCMP + H2O => dUMP + NH4+, Oryza sativa" xref: Reactome:REACT_110788 "dCMP + H2O => dUMP + NH4+, Rattus norvegicus" xref: Reactome:REACT_30304 "dCMP + H2O => dUMP + NH4+, Saccharomyces cerevisiae" xref: Reactome:REACT_31119 "dCMP + H2O => dUMP + NH4+, Schizosaccharomyces pombe" xref: Reactome:REACT_33008 "dCMP + H2O => dUMP + NH4+, Sus scrofa" xref: Reactome:REACT_34269 "dCMP + H2O => dUMP + NH4+, Taeniopygia guttata" xref: Reactome:REACT_81043 "dCMP + H2O => dUMP + NH4+, Bos taurus" xref: Reactome:REACT_82206 "dCMP + H2O => dUMP + NH4+, Mus musculus" xref: Reactome:REACT_84263 "dCMP + H2O => dUMP + NH4+, Drosophila melanogaster" xref: Reactome:REACT_879 "dCMP + H2O => dUMP + NH4+, Homo sapiens" xref: Reactome:REACT_90963 "dCMP + H2O => dUMP + NH4+, Caenorhabditis elegans" xref: Reactome:REACT_95511 "dCMP + H2O => dUMP + NH4+, Gallus gallus" xref: Reactome:REACT_95855 "dCMP + H2O => dUMP + NH4+, Xenopus tropicalis" xref: RHEA:22927 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004133 name: glycogen debranching enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004134 name: 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] xref: EC:2.4.1.25 xref: MetaCyc:AMYLOMALT-RXN xref: MetaCyc:RXN-1828 xref: MetaCyc:RXN-9023 xref: Reactome:REACT_102056 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Xenopus tropicalis" xref: Reactome:REACT_1507 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Homo sapiens" xref: Reactome:REACT_29429 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Danio rerio" xref: Reactome:REACT_29453 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Caenorhabditis elegans" xref: Reactome:REACT_31073 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Canis familiaris" xref: Reactome:REACT_32827 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Saccharomyces cerevisiae" xref: Reactome:REACT_34234 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Gallus gallus" xref: Reactome:REACT_80055 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Sus scrofa" xref: Reactome:REACT_82649 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Bos taurus" xref: Reactome:REACT_83752 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Rattus norvegicus" xref: Reactome:REACT_88252 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Mus musculus" xref: Reactome:REACT_88797 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Taeniopygia guttata" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004135 name: amylo-alpha-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732] subset: gosubset_prok synonym: "amylo-1,6-glucosidase activity" EXACT [] synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] xref: EC:3.2.1.33 xref: MetaCyc:3.2.1.33-RXN xref: Reactome:REACT_106625 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Caenorhabditis elegans" xref: Reactome:REACT_108579 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Saccharomyces cerevisiae" xref: Reactome:REACT_108658 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Sus scrofa" xref: Reactome:REACT_1433 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Homo sapiens" xref: Reactome:REACT_79503 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Canis familiaris" xref: Reactome:REACT_83785 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Rattus norvegicus" xref: Reactome:REACT_84618 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Bos taurus" xref: Reactome:REACT_88815 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Xenopus tropicalis" xref: Reactome:REACT_90121 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Gallus gallus" xref: Reactome:REACT_93342 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Mus musculus" xref: Reactome:REACT_95109 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Taeniopygia guttata" xref: Reactome:REACT_97615 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Danio rerio" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0004136 name: deoxyadenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23455] subset: gosubset_prok synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] xref: EC:2.7.1.76 xref: KEGG:R02089 xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN xref: RHEA:23455 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004137 name: deoxycytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] subset: gosubset_prok synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] xref: EC:2.7.1.74 xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN xref: RHEA:20064 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004138 name: deoxyguanosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19204] subset: gosubset_prok synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] xref: EC:2.7.1.113 xref: KEGG:R01967 xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN xref: RHEA:19204 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004139 name: deoxyribose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824] subset: gosubset_prok synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] xref: EC:4.1.2.4 xref: KEGG:R01066 xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN xref: RHEA:12824 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004140 name: dephospho-CoA kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18248] subset: gosubset_prok synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] xref: EC:2.7.1.24 xref: KEGG:R00130 xref: MetaCyc:DEPHOSPHOCOAKIN-RXN xref: Reactome:REACT_102484 "Phosphorylation of dephospho-CoA to produce CoA, Dictyostelium discoideum" xref: Reactome:REACT_110357 "Phosphorylation of dephospho-CoA to produce CoA, Escherichia coli" xref: Reactome:REACT_11093 "Phosphorylation of dephospho-CoA to produce CoA, Homo sapiens" xref: Reactome:REACT_112662 "Phosphorylation of dephospho-CoA to produce CoA, Plasmodium falciparum" xref: Reactome:REACT_30468 "Phosphorylation of dephospho-CoA to produce CoA, Xenopus tropicalis" xref: Reactome:REACT_30902 "Phosphorylation of dephospho-CoA to produce CoA, Canis familiaris" xref: Reactome:REACT_32306 "Phosphorylation of dephospho-CoA to produce CoA, Drosophila melanogaster" xref: Reactome:REACT_33500 "Phosphorylation of dephospho-CoA to produce CoA, Sus scrofa" xref: Reactome:REACT_82321 "Phosphorylation of dephospho-CoA to produce CoA, Danio rerio" xref: Reactome:REACT_89804 "Phosphorylation of dephospho-CoA to produce CoA, Rattus norvegicus" xref: Reactome:REACT_90005 "Phosphorylation of dephospho-CoA to produce CoA, Caenorhabditis elegans" xref: Reactome:REACT_93983 "Phosphorylation of dephospho-CoA to produce CoA, Taeniopygia guttata" xref: Reactome:REACT_99187 "Phosphorylation of dephospho-CoA to produce CoA, Mus musculus" xref: RHEA:18248 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004141 name: dethiobiotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15808] subset: gosubset_prok synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] xref: EC:6.3.3.3 xref: KEGG:R03182 xref: MetaCyc:DETHIOBIOTIN-SYN-RXN xref: RHEA:15808 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004142 name: diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] synonym: "CPT" RELATED [EC:2.7.8.2] synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] xref: EC:2.7.8.2 xref: MetaCyc:RXN-5781 xref: RHEA:10311 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004143 name: diacylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] subset: gosubset_prok synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "CTP:diacylglycerol kinase activity" NARROW [] synonym: "DG kinase activity" EXACT [EC:2.7.1.107] synonym: "DGK activity" EXACT [EC:2.7.1.107] synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] xref: EC:2.7.1.107 xref: MetaCyc:DIACYLGLYKIN-RXN xref: Reactome:REACT_100005 "DAG kinase produces phosphatidic acid from DAG, Sus scrofa" xref: Reactome:REACT_101911 "DAG kinase produces phosphatidic acid from DAG, Drosophila melanogaster" xref: Reactome:REACT_107713 "DAG kinase produces phosphatidic acid from DAG, Gallus gallus" xref: Reactome:REACT_109578 "DAG kinase produces phosphatidic acid from DAG, Plasmodium falciparum" xref: Reactome:REACT_109644 "DAG kinase produces phosphatidic acid from DAG, Canis familiaris" xref: Reactome:REACT_109845 "DAG kinase produces phosphatidic acid from DAG, Xenopus tropicalis" xref: Reactome:REACT_19402 "DAG kinase produces phosphatidic acid from DAG, Homo sapiens" xref: Reactome:REACT_78206 "DAG kinase produces phosphatidic acid from DAG, Mus musculus" xref: Reactome:REACT_79070 "DAG kinase produces phosphatidic acid from DAG, Rattus norvegicus" xref: Reactome:REACT_93530 "DAG kinase produces phosphatidic acid from DAG, Oryza sativa" xref: Reactome:REACT_95006 "DAG kinase produces phosphatidic acid from DAG, Bos taurus" xref: Reactome:REACT_99113 "DAG kinase produces phosphatidic acid from DAG, Arabidopsis thaliana" xref: Reactome:REACT_99297 "DAG kinase produces phosphatidic acid from DAG, Taeniopygia guttata" xref: Reactome:REACT_99856 "DAG kinase produces phosphatidic acid from DAG, Caenorhabditis elegans" xref: Reactome:REACT_99935 "DAG kinase produces phosphatidic acid from DAG, Danio rerio" xref: RHEA:10275 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004144 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] subset: gosubset_prok synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:REACT_100155 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Rattus norvegicus" xref: Reactome:REACT_103886 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Taeniopygia guttata" xref: Reactome:REACT_104139 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Sus scrofa" xref: Reactome:REACT_104875 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Mus musculus" xref: Reactome:REACT_110678 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Xenopus tropicalis" xref: Reactome:REACT_112540 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Arabidopsis thaliana" xref: Reactome:REACT_112715 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Schizosaccharomyces pombe" xref: Reactome:REACT_114635 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Oryza sativa" xref: Reactome:REACT_22179 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Homo sapiens" xref: Reactome:REACT_28123 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Plasmodium falciparum" xref: Reactome:REACT_28392 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Sus scrofa" xref: Reactome:REACT_31769 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Rattus norvegicus" xref: Reactome:REACT_32550 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Drosophila melanogaster" xref: Reactome:REACT_659 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Homo sapiens" xref: Reactome:REACT_77149 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Oryza sativa" xref: Reactome:REACT_77431 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Canis familiaris" xref: Reactome:REACT_81790 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Bos taurus" xref: Reactome:REACT_88501 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Caenorhabditis elegans" xref: Reactome:REACT_89294 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Danio rerio" xref: Reactome:REACT_89429 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Canis familiaris" xref: Reactome:REACT_92156 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Dictyostelium discoideum" xref: Reactome:REACT_92925 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Gallus gallus" xref: Reactome:REACT_93842 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Xenopus tropicalis" xref: Reactome:REACT_95845 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Bos taurus" xref: Reactome:REACT_96341 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Mus musculus" xref: Reactome:REACT_98065 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Arabidopsis thaliana" xref: Reactome:REACT_98763 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Saccharomyces cerevisiae" xref: Reactome:REACT_99469 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Danio rerio" xref: Reactome:REACT_99733 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Dictyostelium discoideum" xref: RHEA:10871 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0004145 name: diamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] subset: gosubset_prok synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] synonym: "diamine acetyltransferase activity" EXACT [] synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermine acetyltransferase" NARROW [] synonym: "spermine N(1)-acetyltransferase" NARROW [] synonym: "spermine N-acetyltransferase" RELATED [] xref: EC:2.3.1.57 xref: MetaCyc:DIAMACTRANS-RXN xref: Reactome:REACT_102979 "Spermine => N-acetylated spermine, Sus scrofa" xref: Reactome:REACT_103903 "Spermine => N-acetylated spermine, Danio rerio" xref: Reactome:REACT_106439 "Spermine => N-acetylated spermine, Xenopus tropicalis" xref: Reactome:REACT_106602 "Spermine => N-acetylated spermine, Oryza sativa" xref: Reactome:REACT_108255 "Spermine => N-acetylated spermine, Mus musculus" xref: Reactome:REACT_108956 "Spermidine => N-acetylated spermidine, Schizosaccharomyces pombe" xref: Reactome:REACT_14811 "Spermine => N-acetylated spermine, Homo sapiens" xref: Reactome:REACT_14817 "Spermidine => N-acetylated spermidine, Homo sapiens" xref: Reactome:REACT_29565 "Spermine => N-acetylated spermine, Arabidopsis thaliana" xref: Reactome:REACT_31206 "Spermidine => N-acetylated spermidine, Danio rerio" xref: Reactome:REACT_31654 "Spermine => N-acetylated spermine, Gallus gallus" xref: Reactome:REACT_32986 "Spermidine => N-acetylated spermidine, Bos taurus" xref: Reactome:REACT_33438 "Spermidine => N-acetylated spermidine, Caenorhabditis elegans" xref: Reactome:REACT_78089 "Spermidine => N-acetylated spermidine, Mycobacterium tuberculosis" xref: Reactome:REACT_79405 "Spermine => N-acetylated spermine, Canis familiaris" xref: Reactome:REACT_80061 "Spermine => N-acetylated spermine, Drosophila melanogaster" xref: Reactome:REACT_81463 "Spermidine => N-acetylated spermidine, Xenopus tropicalis" xref: Reactome:REACT_81666 "Spermine => N-acetylated spermine, Dictyostelium discoideum" xref: Reactome:REACT_82051 "Spermine => N-acetylated spermine, Taeniopygia guttata" xref: Reactome:REACT_85748 "Spermidine => N-acetylated spermidine, Gallus gallus" xref: Reactome:REACT_85868 "Spermine => N-acetylated spermine, Bos taurus" xref: Reactome:REACT_86359 "Spermine => N-acetylated spermine, Caenorhabditis elegans" xref: Reactome:REACT_86990 "Spermidine => N-acetylated spermidine, Taeniopygia guttata" xref: Reactome:REACT_90627 "Spermidine => N-acetylated spermidine, Canis familiaris" xref: Reactome:REACT_91691 "Spermine => N-acetylated spermine, Rattus norvegicus" xref: Reactome:REACT_92415 "Spermine => N-acetylated spermine, Schizosaccharomyces pombe" xref: Reactome:REACT_92789 "Spermidine => N-acetylated spermidine, Rattus norvegicus" xref: Reactome:REACT_93269 "Spermidine => N-acetylated spermidine, Mus musculus" xref: Reactome:REACT_95402 "Spermine => N-acetylated spermine, Mycobacterium tuberculosis" xref: Reactome:REACT_95517 "Spermidine => N-acetylated spermidine, Drosophila melanogaster" xref: Reactome:REACT_96189 "Spermidine => N-acetylated spermidine, Sus scrofa" xref: Reactome:REACT_96567 "Spermidine => N-acetylated spermidine, Dictyostelium discoideum" xref: Reactome:REACT_97328 "Spermidine => N-acetylated spermidine, Oryza sativa" xref: Reactome:REACT_99684 "Spermidine => N-acetylated spermidine, Arabidopsis thaliana" xref: RHEA:25184 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004146 name: dihydrofolate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "DHFR" RELATED [EC:1.5.1.3] synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolate reduction" EXACT [] synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "folic reductase activity" EXACT [EC:1.5.1.3] synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] xref: EC:1.5.1.3 xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN xref: Reactome:REACT_111041 "Salvage - BH2 is reduced to BH4 by DHFR, Homo sapiens" xref: Reactome:REACT_115762 "Salvage - BH2 is reduced to BH4 by Dhfr, Mus musculus" xref: RHEA:15012 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004147 name: dihydrolipoamide branched chain acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah] subset: gosubset_prok synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] xref: EC:2.3.1.- is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004148 name: dihydrolipoyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] subset: gosubset_prok synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "diaphorase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] synonym: "L-protein activity" RELATED [EC:1.8.1.4] synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] xref: EC:1.8.1.4 xref: MetaCyc:DIHYDLIPOXN-RXN xref: RHEA:15048 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004149 name: dihydrolipoyllysine-residue succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] subset: gosubset_prok synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 is_a: GO:0016751 ! S-succinyltransferase activity [Term] id: GO:0004150 name: dihydroneopterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] xref: EC:4.1.2.25 xref: MetaCyc:H2NEOPTERINALDOL-RXN xref: RHEA:10543 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004151 name: dihydroorotase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24299] subset: gosubset_prok synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] synonym: "DHOase activity" EXACT [EC:3.5.2.3] synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] xref: EC:3.5.2.3 xref: KEGG:R01993 xref: MetaCyc:DIHYDROOROT-RXN xref: Reactome:REACT_100968 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Mus musculus" xref: Reactome:REACT_103707 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Schizosaccharomyces pombe" xref: Reactome:REACT_104176 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Saccharomyces cerevisiae" xref: Reactome:REACT_107004 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Plasmodium falciparum" xref: Reactome:REACT_109520 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Danio rerio" xref: Reactome:REACT_115876 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Gallus gallus" xref: Reactome:REACT_30522 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Bos taurus" xref: Reactome:REACT_32485 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Drosophila melanogaster" xref: Reactome:REACT_32516 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Dictyostelium discoideum" xref: Reactome:REACT_33026 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Caenorhabditis elegans" xref: Reactome:REACT_744 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Homo sapiens" xref: Reactome:REACT_78664 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Taeniopygia guttata" xref: Reactome:REACT_80045 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Rattus norvegicus" xref: Reactome:REACT_89075 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Canis familiaris" xref: Reactome:REACT_99796 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Staphylococcus aureus N315" xref: RHEA:24299 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004152 name: dihydroorotate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076] subset: gosubset_prok synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.5.2] synonym: "(S)-dihydroorotate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.3.5.2] synonym: "DHOdehase activity" EXACT [EC:1.3.5.2] synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.5.2] synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.5.2] xref: EC:1.3.5.2 xref: KEGG:R01868 xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN xref: Reactome:REACT_100074 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Rattus norvegicus" xref: Reactome:REACT_101561 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Arabidopsis thaliana" xref: Reactome:REACT_104099 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Caenorhabditis elegans" xref: Reactome:REACT_105823 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Plasmodium falciparum" xref: Reactome:REACT_106035 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Danio rerio" xref: Reactome:REACT_109840 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Sus scrofa" xref: Reactome:REACT_116075 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Gallus gallus" xref: Reactome:REACT_32121 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Staphylococcus aureus N315" xref: Reactome:REACT_32336 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Saccharomyces cerevisiae" xref: Reactome:REACT_32754 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Xenopus tropicalis" xref: Reactome:REACT_34767 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Taeniopygia guttata" xref: Reactome:REACT_669 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Homo sapiens" xref: Reactome:REACT_77905 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Oryza sativa" xref: Reactome:REACT_79091 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Gallus gallus" xref: Reactome:REACT_82404 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Schizosaccharomyces pombe" xref: Reactome:REACT_87685 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Escherichia coli" xref: Reactome:REACT_89913 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Drosophila melanogaster" xref: Reactome:REACT_90116 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Canis familiaris" xref: Reactome:REACT_96217 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Bos taurus" xref: Reactome:REACT_98035 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Mus musculus" xref: Reactome:REACT_99640 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Mycobacterium tuberculosis" xref: RHEA:18076 is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0004153 name: dihydropterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879] is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004154 name: dihydropterin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189] xref: EC:1.5.3.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004155 name: 6,7-dihydropteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] comment: Note that this function was formerly EC:1.6.99.7. subset: gosubset_prok synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "DHPR activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase activity" EXACT [] synonym: "dihydropteridine reduction" RELATED [] synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] xref: EC:1.5.1.34 xref: MetaCyc:1.5.1.34-RXN xref: Reactome:REACT_101242 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Rattus norvegicus" xref: Reactome:REACT_101276 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Gallus gallus" xref: Reactome:REACT_1925 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Homo sapiens" xref: Reactome:REACT_29183 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Mus musculus" xref: Reactome:REACT_30563 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Dictyostelium discoideum" xref: Reactome:REACT_33125 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Xenopus tropicalis" xref: Reactome:REACT_33238 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Drosophila melanogaster" xref: Reactome:REACT_87568 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Bos taurus" xref: Reactome:REACT_92488 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Canis familiaris" xref: Reactome:REACT_92901 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Caenorhabditis elegans" xref: Reactome:REACT_93858 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Danio rerio" xref: Reactome:REACT_94721 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Taeniopygia guttata" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004156 name: dihydropteroate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] subset: gosubset_prok synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] synonym: "DHPS activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] xref: EC:2.5.1.15 xref: MetaCyc:H2PTEROATESYNTH-RXN xref: RHEA:19952 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004157 name: dihydropyrimidinase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] subset: gosubset_prok synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] xref: EC:3.5.2.2 xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN xref: Reactome:REACT_100830 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Gallus gallus" xref: Reactome:REACT_101446 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Sus scrofa" xref: Reactome:REACT_102809 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Oryza sativa" xref: Reactome:REACT_103556 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Canis familiaris" xref: Reactome:REACT_105429 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Escherichia coli" xref: Reactome:REACT_107309 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Bos taurus" xref: Reactome:REACT_107362 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Sus scrofa" xref: Reactome:REACT_108290 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Xenopus tropicalis" xref: Reactome:REACT_109169 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Xenopus tropicalis" xref: Reactome:REACT_113000 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Drosophila melanogaster" xref: Reactome:REACT_113669 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Drosophila melanogaster" xref: Reactome:REACT_1977 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Homo sapiens" xref: Reactome:REACT_2169 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Homo sapiens" xref: Reactome:REACT_29706 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Taeniopygia guttata" xref: Reactome:REACT_31178 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Arabidopsis thaliana" xref: Reactome:REACT_31256 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Rattus norvegicus" xref: Reactome:REACT_56207 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Mus musculus" xref: Reactome:REACT_81062 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Gallus gallus" xref: Reactome:REACT_82327 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Rattus norvegicus" xref: Reactome:REACT_82436 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Dictyostelium discoideum" xref: Reactome:REACT_85710 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Taeniopygia guttata" xref: Reactome:REACT_87087 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Arabidopsis thaliana" xref: Reactome:REACT_87711 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Mus musculus" xref: Reactome:REACT_89192 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Danio rerio" xref: Reactome:REACT_89935 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Dictyostelium discoideum" xref: Reactome:REACT_90336 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Escherichia coli" xref: Reactome:REACT_95295 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Danio rerio" xref: Reactome:REACT_95705 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Bos taurus" xref: Reactome:REACT_98259 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Canis familiaris" xref: Reactome:REACT_99864 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Oryza sativa" xref: RHEA:16124 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004158 name: dihydroorotate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444] comment: This term represents a deleted EC activity and is scheduled for obsoletion. subset: mf_needs_review synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] xref: EC:1.3.3.1 xref: RHEA:15444 is_a: GO:0004152 ! dihydroorotate dehydrogenase activity is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004159 name: dihydrouracil dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] xref: EC:1.3.1.1 xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN xref: RHEA:20192 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004160 name: dihydroxy-acid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] subset: gosubset_prok synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "DHAD" RELATED [EC:4.2.1.9] synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] xref: EC:4.2.1.9 xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN xref: RHEA:20939 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004161 name: dimethylallyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyltransferase activity" EXACT [] synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] xref: EC:2.5.1.1 xref: MetaCyc:GPPSYN-RXN xref: Reactome:REACT_100741 "Addition of isopentenyl pyrophosphate to DMAPP, Sus scrofa" xref: Reactome:REACT_102050 "Addition of isopentenyl pyrophosphate to DMAPP, Oryza sativa" xref: Reactome:REACT_102118 "Addition of isopentenyl pyrophosphate to DMAPP, Schizosaccharomyces pombe" xref: Reactome:REACT_102935 "Addition of isopentenyl pyrophosphate to DMAPP, Arabidopsis thaliana" xref: Reactome:REACT_103677 "Addition of isopentenyl pyrophosphate to DMAPP, Mus musculus" xref: Reactome:REACT_104071 "Addition of isopentenyl pyrophosphate to DMAPP, Taeniopygia guttata" xref: Reactome:REACT_107473 "Addition of isopentenyl pyrophosphate to DMAPP, Saccharomyces cerevisiae" xref: Reactome:REACT_108928 "Addition of isopentenyl pyrophosphate to DMAPP, Gallus gallus" xref: Reactome:REACT_109017 "Addition of isopentenyl pyrophosphate to DMAPP, Canis familiaris" xref: Reactome:REACT_34263 "Addition of isopentenyl pyrophosphate to DMAPP, Xenopus tropicalis" xref: Reactome:REACT_34609 "Addition of isopentenyl pyrophosphate to DMAPP, Caenorhabditis elegans" xref: Reactome:REACT_79289 "Addition of isopentenyl pyrophosphate to DMAPP, Drosophila melanogaster" xref: Reactome:REACT_87054 "Addition of isopentenyl pyrophosphate to DMAPP, Rattus norvegicus" xref: Reactome:REACT_88460 "Addition of isopentenyl pyrophosphate to DMAPP, Danio rerio" xref: Reactome:REACT_89249 "Addition of isopentenyl pyrophosphate to DMAPP, Plasmodium falciparum" xref: Reactome:REACT_9467 "Addition of isopentenyl pyrophosphate to DMAPP, Homo sapiens" xref: Reactome:REACT_96140 "Addition of isopentenyl pyrophosphate to DMAPP, Dictyostelium discoideum" xref: Reactome:REACT_99636 "Addition of isopentenyl pyrophosphate to DMAPP, Bos taurus" xref: RHEA:22411 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004162 name: dimethylnitrosamine demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0004163 name: diphosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735] subset: gosubset_prok synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] xref: EC:4.1.1.33 xref: KEGG:R01121 xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN xref: Reactome:REACT_100521 "Mevalonate-5-pyrophosphate is decarboxylated, Dictyostelium discoideum" xref: Reactome:REACT_101376 "Mevalonate-5-pyrophosphate is decarboxylated, Drosophila melanogaster" xref: Reactome:REACT_102913 "Mevalonate-5-pyrophosphate is decarboxylated, Gallus gallus" xref: Reactome:REACT_104999 "Mevalonate-5-pyrophosphate is decarboxylated, Xenopus tropicalis" xref: Reactome:REACT_105125 "Mevalonate-5-pyrophosphate is decarboxylated, Mus musculus" xref: Reactome:REACT_108444 "Mevalonate-5-pyrophosphate is decarboxylated, Rattus norvegicus" xref: Reactome:REACT_109965 "Mevalonate-5-pyrophosphate is decarboxylated, Saccharomyces cerevisiae" xref: Reactome:REACT_28129 "Mevalonate-5-pyrophosphate is decarboxylated, Canis familiaris" xref: Reactome:REACT_33654 "Mevalonate-5-pyrophosphate is decarboxylated, Schizosaccharomyces pombe" xref: Reactome:REACT_78028 "Mevalonate-5-pyrophosphate is decarboxylated, Danio rerio" xref: Reactome:REACT_80726 "Mevalonate-5-pyrophosphate is decarboxylated, Oryza sativa" xref: Reactome:REACT_81266 "Mevalonate-5-pyrophosphate is decarboxylated, Arabidopsis thaliana" xref: Reactome:REACT_81926 "Mevalonate-5-pyrophosphate is decarboxylated, Staphylococcus aureus N315" xref: Reactome:REACT_81997 "Mevalonate-5-pyrophosphate is decarboxylated, Caenorhabditis elegans" xref: Reactome:REACT_92755 "Mevalonate-5-pyrophosphate is decarboxylated, Bos taurus" xref: Reactome:REACT_9488 "Mevalonate-5-pyrophosphate is decarboxylated, Homo sapiens" xref: Reactome:REACT_95775 "Mevalonate-5-pyrophosphate is decarboxylated, Taeniopygia guttata" xref: RHEA:23735 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004164 name: diphthine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] subset: gosubset_prok synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] xref: EC:2.1.1.98 xref: MetaCyc:RXN-11370 xref: RHEA:20148 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004165 name: dodecenoyl-CoA delta-isomerase activity namespace: molecular_function alt_id: GO:0008461 def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] subset: gosubset_prok synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] xref: EC:5.3.3.8 xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN xref: Reactome:REACT_104001 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Canis familiaris" xref: Reactome:REACT_28905 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Drosophila melanogaster" xref: Reactome:REACT_588 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Homo sapiens" xref: Reactome:REACT_78170 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_87434 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Mycobacterium tuberculosis" xref: Reactome:REACT_88442 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_88978 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Danio rerio" xref: Reactome:REACT_95247 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Gallus gallus" xref: Reactome:REACT_95915 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_96247 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Mus musculus" xref: Reactome:REACT_98886 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Bos taurus" xref: RHEA:23719 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004166 name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0004101 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] xref: EC:2.4.1.153 xref: MetaCyc:2.4.1.153-RXN xref: RHEA:14696 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004167 name: dopachrome isomerase activity namespace: molecular_function alt_id: GO:0048059 def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13044] synonym: "DCF activity" EXACT [EC:5.3.3.12] synonym: "DCT activity" EXACT [EC:5.3.3.12] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome delta-isomerase activity" EXACT [] synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] synonym: "TRP activity" EXACT [EC:5.3.3.12] synonym: "TRP-1" RELATED [EC:5.3.3.12] synonym: "TRP-2" RELATED [EC:5.3.3.12] synonym: "TRP2" RELATED [EC:5.3.3.12] synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] xref: EC:5.3.3.12 xref: KEGG:R03673 xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN xref: RHEA:13044 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004168 name: dolichol kinase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] xref: EC:2.7.1.108 xref: MetaCyc:DOLICHOL-KINASE-RXN xref: Reactome:REACT_22276 "Phosphorylation of dolichol, Homo sapiens" xref: RHEA:13136 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004169 name: dolichyl-phosphate-mannose-protein mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109] subset: gosubset_prok synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] synonym: "O-glycoside mannosyltransferase" BROAD [] synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "protein O-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.109 xref: MetaCyc:2.4.1.109-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: gosubset_prok synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: KEGG:R02100 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:REACT_103311 "dUTP + H2O => dUMP + pyrophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_106534 "dUTP + H2O => dUMP + pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_108277 "dUTP + H2O => dUMP + pyrophosphate, Canis familiaris" xref: Reactome:REACT_108948 "dUTP + H2O => dUMP + pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_109343 "dUTP + H2O => dUMP + pyrophosphate, Gallus gallus" xref: Reactome:REACT_150 "dUTP + H2O => dUMP + pyrophosphate, Homo sapiens" xref: Reactome:REACT_30531 "dUTP + H2O => dUMP + pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_54215 "dUTP + H2O => dUMP + pyrophosphate, Bos taurus" xref: Reactome:REACT_76954 "dUTP + H2O => dUMP + pyrophosphate, Dictyostelium discoideum" xref: Reactome:REACT_77124 "dUTP + H2O => dUMP + pyrophosphate, Danio rerio" xref: Reactome:REACT_81301 "dUTP + H2O => dUMP + pyrophosphate, Arabidopsis thaliana" xref: Reactome:REACT_82609 "dUTP + H2O => dUMP + pyrophosphate, Mus musculus" xref: Reactome:REACT_87407 "dUTP + H2O => dUMP + pyrophosphate, Escherichia coli" xref: Reactome:REACT_92173 "dUTP + H2O => dUMP + pyrophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_92619 "dUTP + H2O => dUMP + pyrophosphate, Caenorhabditis elegans" xref: Reactome:REACT_96660 "dUTP + H2O => dUMP + pyrophosphate, Oryza sativa" xref: Reactome:REACT_96711 "dUTP + H2O => dUMP + pyrophosphate, Plasmodium falciparum" xref: Reactome:REACT_97265 "dUTP + H2O => dUMP + pyrophosphate, Taeniopygia guttata" xref: RHEA:10251 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0004171 name: deoxyhypusine synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] comment: This term was made obsolete because it represents a multistep reaction. synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] is_obsolete: true replaced_by: GO:0008612 replaced_by: GO:0034038 replaced_by: GO:0050983 [Term] id: GO:0004172 name: ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. is_obsolete: true consider: GO:0050488 [Term] id: GO:0004173 name: ecdysone O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15220] synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] xref: EC:2.3.1.139 xref: KEGG:R02375 xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN xref: RHEA:15220 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004174 name: electron-transferring-flavoprotein dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] subset: gosubset_prok synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: MetaCyc:1.5.5.1-RXN xref: Reactome:REACT_101766 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Oryza sativa" xref: Reactome:REACT_108322 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Danio rerio" xref: Reactome:REACT_108711 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Rattus norvegicus" xref: Reactome:REACT_32375 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Taeniopygia guttata" xref: Reactome:REACT_32665 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Saccharomyces cerevisiae" xref: Reactome:REACT_32923 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Arabidopsis thaliana" xref: Reactome:REACT_34198 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Sus scrofa" xref: Reactome:REACT_6169 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Homo sapiens" xref: Reactome:REACT_82024 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Escherichia coli" xref: Reactome:REACT_82357 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Canis familiaris" xref: Reactome:REACT_84406 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Schizosaccharomyces pombe" xref: Reactome:REACT_84920 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Bos taurus" xref: Reactome:REACT_85394 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Caenorhabditis elegans" xref: Reactome:REACT_88723 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Dictyostelium discoideum" xref: Reactome:REACT_88890 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Drosophila melanogaster" xref: Reactome:REACT_95350 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Mus musculus" xref: Reactome:REACT_98526 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Xenopus tropicalis" is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "endoprotease activity" EXACT [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" BROAD [] xref: Reactome:REACT_10017 "Degradation of ubiquitinated -beta catenin by the proteasome, Homo sapiens" xref: Reactome:REACT_101348 "Degradation of multiubiquitinated Cdh1, Rattus norvegicus" xref: Reactome:REACT_101866 "Ubiquitinated Cdc6 is degraded by the proteasome, Canis familiaris" xref: Reactome:REACT_101873 "Degradation of multiubiquitinated cell cycle proteins, Mus musculus" xref: Reactome:REACT_102952 "Degradation of multiubiquitinated Cdh1, Bos taurus" xref: Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis" xref: Reactome:REACT_104331 "Ubiquitinated geminin is degraded by the proteasome, Mus musculus" xref: Reactome:REACT_104435 "Proteasome mediated degradation of Cyclin D1, Rattus norvegicus" xref: Reactome:REACT_104684 "Degradation of multiubiquitinated Cdh1, Danio rerio" xref: Reactome:REACT_104793 "Ubiquitinated Cdc6 is degraded by the proteasome, Mus musculus" xref: Reactome:REACT_105135 "Degradation of ubiquitinated -beta catenin by the proteasome, Canis familiaris" xref: Reactome:REACT_105245 "Ubiquitinated Orc1 is degraded by the proteasome, Danio rerio" xref: Reactome:REACT_105748 "APC/C:Cdh1-mediated degradation of Skp2, Canis familiaris" xref: Reactome:REACT_106234 "Ubiquitinated Orc1 is degraded by the proteasome, Mus musculus" xref: Reactome:REACT_106385 "Proteasome mediated degradation of COP1, Xenopus tropicalis" xref: Reactome:REACT_106617 "gamma-secretase cleaves the p75NTR transmembrane domain, Bos taurus" xref: Reactome:REACT_106687 "SCF-mediated degradation of Emi1, Bos taurus" xref: Reactome:REACT_107139 "Ubiquitinated geminin is degraded by the proteasome, Canis familiaris" xref: Reactome:REACT_107146 "Ubiquitinated Orc1 is degraded by the proteasome, Bos taurus" xref: Reactome:REACT_108185 "Ubiquitinated Orc1 is degraded by the proteasome, Oryza sativa" xref: Reactome:REACT_108448 "Proteasome mediated degradation of PAK-2p34, Mus musculus" xref: Reactome:REACT_108642 "Ubiquitinated geminin is degraded by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_109047 "Degradation of multiubiquitinated Cdh1, Oryza sativa" xref: Reactome:REACT_109186 "Ubiquitinated Cdc6 is degraded by the proteasome, Danio rerio" xref: Reactome:REACT_109261 "Degradation of multiubiquitinated cell cycle proteins, Oryza sativa" xref: Reactome:REACT_110165 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Danio rerio" xref: Reactome:REACT_110191 "26S proteosome degrades ODC holoenzyme complex, Canis familiaris" xref: Reactome:REACT_110448 "Proteolytic degradation of ubiquitinated-Cdc25A, Xenopus tropicalis" xref: Reactome:REACT_110469 "gamma-secretase cleaves the p75NTR transmembrane domain, Rattus norvegicus" xref: Reactome:REACT_110487 "Proteolytic degradation of ubiquitinated-Cdc25A, Danio rerio" xref: Reactome:REACT_110752 "gamma-secretase cleaves the p75NTR transmembrane domain, Canis familiaris" xref: Reactome:REACT_111098 "Processing of SCF isoform 1, Homo sapiens" xref: Reactome:REACT_111104 "Proteasomal cleavage of substrate, Homo sapiens" xref: Reactome:REACT_111172 "Proteasomal clevage of exogenous antigen, Homo sapiens" xref: Reactome:REACT_112076 "Ubiquitinated Cdc6 is degraded by the proteasome, Sus scrofa" xref: Reactome:REACT_113623 "Ubiquitinated geminin is degraded by the proteasome, Sus scrofa" xref: Reactome:REACT_113749 "Ubiquitinated Orc1 is degraded by the proteasome, Sus scrofa" xref: Reactome:REACT_114002 "Proteasome mediated degradation of PAK-2p34, Sus scrofa" xref: Reactome:REACT_114449 "Proteasome mediated degradation of Cyclin D1, Sus scrofa" xref: Reactome:REACT_114993 "Proteasome mediated degradation of COP1, Sus scrofa" xref: Reactome:REACT_115363 "Proteasome mediated degradation of Cyclin D1, Oryza sativa" xref: Reactome:REACT_115913 "Cleavage of ERBB4m80 by gamma-scretase complex, Homo sapiens" xref: Reactome:REACT_1210 "Ubiquitinated Cdc6 is degraded by the proteasome, Homo sapiens" xref: Reactome:REACT_13413 "Proteasome mediated degradation of PAK-2p34, Homo sapiens" xref: Reactome:REACT_13491 "26S proteosome degrades ODC holoenzyme complex, Homo sapiens" xref: Reactome:REACT_13505 "Proteasome mediated degradation of PAK-2p34, Homo sapiens" xref: Reactome:REACT_1355 "Insulin degradation, Homo sapiens" xref: Reactome:REACT_13609 "gamma-secretase cleaves the p75NTR transmembrane domain, Homo sapiens" xref: Reactome:REACT_1471 "Ubiquitinated geminin is degraded by the proteasome, Homo sapiens" xref: Reactome:REACT_15476 "Corticotropin cleavage from POMC, Homo sapiens" xref: Reactome:REACT_1673 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex, Homo sapiens" xref: Reactome:REACT_20637 "Proteasome mediated degradation of COP1, Homo sapiens" xref: Reactome:REACT_2142 "Proteasome mediated degradation of Cyclin D1, Homo sapiens" xref: Reactome:REACT_25343 "Destruction of AUF1 and mRNA, Homo sapiens" xref: Reactome:REACT_28448 "Ubiquitinated Orc1 is degraded by the proteasome, Dictyostelium discoideum" xref: Reactome:REACT_28452 "Proteasome mediated degradation of COP1, Bos taurus" xref: Reactome:REACT_28694 "Proteasome mediated degradation of Cyclin D1, Bos taurus" xref: Reactome:REACT_29497 "Corticotropin cleavage from POMC, Rattus norvegicus" xref: Reactome:REACT_29888 "Proteasome mediated degradation of COP1, Dictyostelium discoideum" xref: Reactome:REACT_30554 "APC/C:Cdh1-mediated degradation of Skp2, Mus musculus" xref: Reactome:REACT_31644 "Degradation of ubiquitinated -beta catenin by the proteasome, Mus musculus" xref: Reactome:REACT_32286 "Corticotropin cleavage from POMC, Gallus gallus" xref: Reactome:REACT_32345 "Proteasome mediated degradation of COP1, Rattus norvegicus" xref: Reactome:REACT_32454 "Corticotropin cleavage from POMC, Mus musculus" xref: Reactome:REACT_33103 "26S proteosome degrades ODC holoenzyme complex, Xenopus tropicalis" xref: Reactome:REACT_33361 "Degradation of multiubiquitinated Securin, Xenopus tropicalis" xref: Reactome:REACT_33702 "Proteasome mediated degradation of PAK-2p34, Drosophila melanogaster" xref: Reactome:REACT_34207 "Proteasome mediated degradation of PAK-2p34, Canis familiaris" xref: Reactome:REACT_34441 "Proteolytic degradation of ubiquitinated-Cdc25A, Rattus norvegicus" xref: Reactome:REACT_38775 "Ubiquitinated geminin is degraded by the proteasome, Bos taurus" xref: Reactome:REACT_480 "Ubiquitinated Orc1 is degraded by the proteasome, Homo sapiens" xref: Reactome:REACT_6715 "Degradation of multiubiquitinated Cdh1, Homo sapiens" xref: Reactome:REACT_6777 "Degradation of multiubiquitinated Securin, Homo sapiens" xref: Reactome:REACT_6826 "Degradation of multiubiquitinated cell cycle proteins, Homo sapiens" xref: Reactome:REACT_6878 "SCF-mediated degradation of Emi1, Homo sapiens" xref: Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens" xref: Reactome:REACT_75798 "Trimming of peptides in ER, Homo sapiens" xref: Reactome:REACT_75871 "Proteasomal cleavage of substrate, Homo sapiens" xref: Reactome:REACT_78097 "Proteasome mediated degradation of COP1, Canis familiaris" xref: Reactome:REACT_78726 "gamma-secretase cleaves the p75NTR transmembrane domain, Xenopus tropicalis" xref: Reactome:REACT_78745 "Proteasome mediated degradation of Cyclin D1, Drosophila melanogaster" xref: Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus" xref: Reactome:REACT_79225 "Degradation of multiubiquitinated Cdh1, Canis familiaris" xref: Reactome:REACT_79268 "Degradation of ubiquitinated -beta catenin by the proteasome, Drosophila melanogaster" xref: Reactome:REACT_79271 "Proteasome mediated degradation of Cyclin D1, Canis familiaris" xref: Reactome:REACT_79593 "Corticotropin cleavage from POMC, Xenopus tropicalis" xref: Reactome:REACT_79599 "26S proteosome degrades ODC holoenzyme complex, Danio rerio" xref: Reactome:REACT_79815 "gamma-secretase cleaves the p75NTR transmembrane domain, Gallus gallus" xref: Reactome:REACT_79882 "APC/C:Cdh1-mediated degradation of Skp2, Rattus norvegicus" xref: Reactome:REACT_80109 "gamma-secretase cleaves the p75NTR transmembrane domain, Danio rerio" xref: Reactome:REACT_80331 "APC/C:Cdh1-mediated degradation of Skp2, Xenopus tropicalis" xref: Reactome:REACT_80442 "Ubiquitinated Cdc6 is degraded by the proteasome, Drosophila melanogaster" xref: Reactome:REACT_80463 "Degradation of multiubiquitinated Securin, Danio rerio" xref: Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus" xref: Reactome:REACT_80774 "Degradation of multiubiquitinated cell cycle proteins, Rattus norvegicus" xref: Reactome:REACT_80978 "Proteasome mediated degradation of PAK-2p34, Xenopus tropicalis" xref: Reactome:REACT_81238 "Corticotropin cleavage from POMC, Bos taurus" xref: Reactome:REACT_81327 "SCF-mediated degradation of Emi1, Mus musculus" xref: Reactome:REACT_81867 "Ubiquitinated Cdc6 is degraded by the proteasome, Bos taurus" xref: Reactome:REACT_81958 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Canis familiaris" xref: Reactome:REACT_82043 "Ubiquitinated Orc1 is degraded by the proteasome, Canis familiaris" xref: Reactome:REACT_82474 "Ubiquitinated Cdc6 is degraded by the proteasome, Dictyostelium discoideum" xref: Reactome:REACT_82600 "Degradation of multiubiquitinated cell cycle proteins, Xenopus tropicalis" xref: Reactome:REACT_82845 "26S proteosome degrades ODC holoenzyme complex, Rattus norvegicus" xref: Reactome:REACT_82963 "Degradation of multiubiquitinated cell cycle proteins, Drosophila melanogaster" xref: Reactome:REACT_83099 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Bos taurus" xref: Reactome:REACT_83216 "gamma-secretase cleaves the p75NTR transmembrane domain, Sus scrofa" xref: Reactome:REACT_83748 "Degradation of multiubiquitinated Cdh1, Drosophila melanogaster" xref: Reactome:REACT_84139 "Proteasome mediated degradation of COP1, Danio rerio" xref: Reactome:REACT_85078 "APC/C:Cdh1-mediated degradation of Skp2, Drosophila melanogaster" xref: Reactome:REACT_86353 "Corticotropin cleavage from POMC, Danio rerio" xref: Reactome:REACT_86565 "SCF-mediated degradation of Emi1, Rattus norvegicus" xref: Reactome:REACT_873 "Proteolytic degradation of ubiquitinated-Cdc25A, Homo sapiens" xref: Reactome:REACT_88382 "Proteasome mediated degradation of COP1, Mus musculus" xref: Reactome:REACT_88509 "Proteasome mediated degradation of Cyclin D1, Mus musculus" xref: Reactome:REACT_88535 "Ubiquitinated Orc1 is degraded by the proteasome, Plasmodium falciparum" xref: Reactome:REACT_88610 "Degradation multiubiquitinated Cyclin A, Canis familiaris" xref: Reactome:REACT_88818 "Degradation multiubiquitinated Cyclin A, Drosophila melanogaster" xref: Reactome:REACT_88854 "Corticotropin cleavage from POMC, Taeniopygia guttata" xref: Reactome:REACT_89011 "Ubiquitinated Orc1 is degraded by the proteasome, Rattus norvegicus" xref: Reactome:REACT_89036 "Ubiquitinated geminin is degraded by the proteasome, Danio rerio" xref: Reactome:REACT_89437 "26S proteosome degrades ODC holoenzyme complex, Bos taurus" xref: Reactome:REACT_89505 "Corticotropin cleavage from POMC, Sus scrofa" xref: Reactome:REACT_89706 "Degradation of multiubiquitinated Cdh1, Xenopus tropicalis" xref: Reactome:REACT_90062 "SCF-mediated degradation of Emi1, Canis familiaris" xref: Reactome:REACT_9018 "Degradation of ubiquitinated CD4, Homo sapiens" xref: Reactome:REACT_9034 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Homo sapiens" xref: Reactome:REACT_9035 "APC/C:Cdh1-mediated degradation of Skp2, Homo sapiens" xref: Reactome:REACT_90527 "SCF-mediated degradation of Emi1, Drosophila melanogaster" xref: Reactome:REACT_90608 "Proteasome mediated degradation of Cyclin D1, Danio rerio" xref: Reactome:REACT_91284 "Degradation of ubiquitinated -beta catenin by the proteasome, Bos taurus" xref: Reactome:REACT_91685 "Degradation of ubiquitinated -beta catenin by the proteasome, Rattus norvegicus" xref: Reactome:REACT_91903 "Ubiquitinated Cdc6 is degraded by the proteasome, Rattus norvegicus" xref: Reactome:REACT_92046 "Corticotropin cleavage from POMC, Canis familiaris" xref: Reactome:REACT_92221 "Ubiquitinated Cdc6 is degraded by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_92347 "Proteasome mediated degradation of COP1, Oryza sativa" xref: Reactome:REACT_92586 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Xenopus tropicalis" xref: Reactome:REACT_92969 "Proteolytic degradation of ubiquitinated-Cdc25A, Bos taurus" xref: Reactome:REACT_93063 "Proteasome mediated degradation of PAK-2p34, Danio rerio" xref: Reactome:REACT_93174 "SCF-mediated degradation of Emi1, Xenopus tropicalis" xref: Reactome:REACT_93453 "Degradation of multiubiquitinated Cdh1, Mus musculus" xref: Reactome:REACT_93935 "gamma-secretase cleaves the p75NTR transmembrane domain, Mus musculus" xref: Reactome:REACT_94290 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Rattus norvegicus" xref: Reactome:REACT_9466 "Proteosome-mediated degradation of APOBEC3G, Homo sapiens" xref: Reactome:REACT_94694 "Degradation of multiubiquitinated Securin, Canis familiaris" xref: Reactome:REACT_95326 "Degradation of multiubiquitinated cell cycle proteins, Canis familiaris" xref: Reactome:REACT_95413 "Degradation of multiubiquitinated cell cycle proteins, Danio rerio" xref: Reactome:REACT_95513 "Proteolytic degradation of ubiquitinated-Cdc25A, Canis familiaris" xref: Reactome:REACT_95865 "Proteolytic degradation of ubiquitinated-Cdc25A, Mus musculus" xref: Reactome:REACT_96387 "Degradation multiubiquitinated Cyclin A, Mus musculus" xref: Reactome:REACT_96712 "Degradation of multiubiquitinated Securin, Drosophila melanogaster" xref: Reactome:REACT_96853 "Ubiquitinated Orc1 is degraded by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_96908 "Ubiquitinated Orc1 is degraded by the proteasome, Drosophila melanogaster" xref: Reactome:REACT_97049 "Ubiquitinated Cdc6 is degraded by the proteasome, Oryza sativa" xref: Reactome:REACT_97235 "APC/C:Cdh1-mediated degradation of Skp2, Danio rerio" xref: Reactome:REACT_97302 "Proteasome mediated degradation of Cyclin D1, Xenopus tropicalis" xref: Reactome:REACT_97473 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Mus musculus" xref: Reactome:REACT_97709 "Degradation multiubiquitinated Cyclin A, Danio rerio" xref: Reactome:REACT_97826 "Degradation of multiubiquitinated cell cycle proteins, Bos taurus" xref: Reactome:REACT_97966 "APC/C:Cdh1-mediated degradation of Skp2, Oryza sativa" xref: Reactome:REACT_98412 "APC/C:Cdh1-mediated degradation of Skp2, Bos taurus" xref: Reactome:REACT_98429 "Degradation of ubiquitinated -beta catenin by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_98617 "Degradation of multiubiquitinated Securin, Mus musculus" xref: Reactome:REACT_98707 "Proteasome mediated degradation of PAK-2p34, Rattus norvegicus" xref: Reactome:REACT_98822 "Degradation of multiubiquitinated Securin, Rattus norvegicus" xref: Reactome:REACT_98901 "Degradation of multiubiquitinated Securin, Bos taurus" xref: Reactome:REACT_98932 "Ubiquitinated geminin is degraded by the proteasome, Rattus norvegicus" xref: Reactome:REACT_99506 "26S proteosome degrades ODC holoenzyme complex, Mus musculus" xref: Reactome:REACT_99644 "Proteolytic degradation of ubiquitinated-Cdc25A, Drosophila melanogaster" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] subset: gosubset_prok synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004177 name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] subset: gosubset_prok xref: EC:3.4.11 xref: Reactome:REACT_111222 "Trimming of peptides by IRAP in endocytic vesicles, Homo sapiens" xref: Reactome:REACT_75931 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases, Homo sapiens" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004178 name: leucyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] synonym: "cathepsin III" RELATED [EC:3.4.11.1] synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] synonym: "FTBL proteins" RELATED [EC:3.4.11.1] synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] synonym: "peptidase S activity" NARROW [EC:3.4.11.1] synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] xref: EC:3.4.11.1 xref: MetaCyc:3.4.11.1-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004179 name: membrane alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] synonym: "CD13" RELATED [EC:3.4.11.2] synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "peptidase E activity" BROAD [EC:3.4.11.2] synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] xref: EC:3.4.11.2 xref: MetaCyc:3.4.11.2-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004180 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] subset: gosubset_prok xref: Reactome:REACT_75845 "A dipeptidase cleaves cysteinylglycine, Homo sapiens" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004181 name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] subset: gosubset_prok xref: EC:3.4.17 xref: Reactome:REACT_103434 "Processing of Proinsulin to Insulin, Rattus norvegicus" xref: Reactome:REACT_104808 "Processing of Proinsulin to Insulin, Taeniopygia guttata" xref: Reactome:REACT_15374 "Processing of Proinsulin to Insulin, Homo sapiens" xref: Reactome:REACT_30489 "Processing of Proinsulin to Insulin, Danio rerio" xref: Reactome:REACT_31280 "Processing of Proinsulin to Insulin, Xenopus tropicalis" xref: Reactome:REACT_34275 "Processing of Proinsulin to Insulin, Bos taurus" xref: Reactome:REACT_76942 "Processing of Proinsulin to Insulin, Canis familiaris" xref: Reactome:REACT_85582 "Processing of Proinsulin to Insulin, Mus musculus" xref: Reactome:REACT_93274 "Processing of Proinsulin to Insulin, Gallus gallus" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0004182 name: carboxypeptidase A activity namespace: molecular_function alt_id: GO:0008731 def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] xref: EC:3.4.17.1 xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004183 name: carboxypeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase H activity" EXACT [] synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] xref: EC:3.4.17.10 xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004184 name: lysine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] comment: This term was made obsolete because it represents a gene product. synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "bradykinase activity" EXACT [EC:3.4.17.3] synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] synonym: "carboxypeptidase N activity" EXACT [] synonym: "CPase N" RELATED [EC:3.4.17.3] synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] synonym: "kininase I activity" EXACT [EC:3.4.17.3] synonym: "kininase Ia" RELATED [EC:3.4.17.3] synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] xref: EC:3.4.17.3 xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004185 name: serine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "serine carboxypeptidase activity" EXACT [] xref: EC:3.4.16 xref: Reactome:REACT_109426 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Bos taurus" xref: Reactome:REACT_6 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Homo sapiens" xref: Reactome:REACT_79406 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Mus musculus" xref: Reactome:REACT_83670 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Rattus norvegicus" xref: Reactome:REACT_92499 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Gallus gallus" xref: Reactome:REACT_95826 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Canis familiaris" xref: Reactome:REACT_98506 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Taeniopygia guttata" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0004186 name: carboxypeptidase C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a